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MCID: XRD018

Xeroderma Pigmentosum, Group a malady
23 genes, 3 tissues, 217 related diseases, 20 phenotypes, 40 articles, clinical trials.

Summaries for Xeroderma Pigmentosum, Group a

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33OMIM, 22MalaCards
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MalaCards: Xeroderma Pigmentosum, Group a, also known as xeroderma, is related to xeroderma pigmentosum and multiple self healing squamous epithelioma. An important gene associated with Xeroderma Pigmentosum, Group a is XPA (xeroderma pigmentosum, complementation group A), and among its related pathways are Dual incision reaction in GG-NER and Mismatch repair. The compounds cpds and cyanine have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and lung, and related mouse phenotypes are endocrine/exocrine gland and respiratory system.

OMIM: 278700

Aliases & Descriptions for Xeroderma Pigmentosum, Group a

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33OMIM, 43UMLS
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xeroderma pigmentosum, group a 33
xeroderma 43

Related Diseases for Xeroderma Pigmentosum, Group a

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13GeneCards, 14GeneDecks
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Disease types for xeroderma pigmentosum, group a family:

xeroderma pigmentosum, group c xeroderma pigmentosum, group d
xeroderma pigmentosum, group b xeroderma pigmentosum, group g
xeroderma pigmentosum, group f

Diseases related to xeroderma pigmentosum, group a by text searches and GeneDecks gene sharing:

(show top 50)    (show all 209)
idRelated DiseaseScoreTop Affiliating Genes
1xeroderma pigmentosum39.1XPA, XPC
2multiple self healing squamous epithelioma31.1XPA, MSSE, FANCC, PTCH1
3progeria30.5LMNA, XPA, ERCC4, TP53
4nevoid basal cell carcinoma syndrome29.9PCNA, XPA, FANCC, TP53, PTCH1
5esophageal squamous cell carcinoma29.1PCNA, LMNA, XPA, XPC, TP53, PTCH1
6basal cell carcinoma28.8PCNA, LMNA, XPA, XPC, MSSE, FANCC
7cockayne syndrome28.5PCNA, XPA, XPC, ATM, ERCC4, TP53
8breast cancer27.8ATR, ATM, FANCC, TP53
9squamous cell carcinoma27.7PCNA, XPA, XPC, FANCC, CALB2, ERCC4
10lung adenocarcinoma27.6XPA, CALB2, TP53, TOP1
11ataxia telangiectasia26.2PCNA, XPA, XPC, ATR, ATM, FANCC
12protein s deficiency26.2LMNA, XPA, TP53, PSAP
13leiomyoma25.9PCNA, XPA, CALB2, HMGA1, TP53
14esophagitis25.1PCNA, LMNA, XPA, XPC, ATR, ATM
15testicular cancer25.1XPC, ATM, TP53, TOP1
16herpes simplex24.7PCNA, LMNA, ATR, ATM, CALB2, TP53
17neurodegeneration24.6ATM, CALB2, TP53, TPH1, PVALB, SOD1
18ataxia24.5PCNA, XPA, XPC, ATR, ATM, FANCC
19epithelial ovarian cancer24.1ATR, ATM, FANCC, ERCC4, TP53, TOP1
20skin cancer23.9PCNA, XPA, XPC, MSSE, FANCC, ERCC4
21ovarian carcinoma23.8PCNA, XPA, XPC, ATR, CALB2, HMGA1
22melanoma23.1PCNA, LMNA, XPA, XPC, MSSE, ATM
23esophageal cancer23.0PCNA, XPA, XPC, ATM, TP53, PTCH1
24carcinoma22.6RECQL4, PCNA, LMNA, XPA, XPC, MSSE
25nasopharyngitis22.6PCNA, XPC, ATM, TP53, PTCH1, TOP1
26ovarian cancer22.3PCNA, LMNA, XPA, XPC, ATR, ATM
27hepatocellular carcinoma22.1PCNA, LMNA, XPA, XPC, FANCC, HMGA1
28adenocarcinoma21.8PCNA, LMNA, XPA, XPC, ATR, ATM
29anemia21.6PCNA, LMNA, XPA, ATR, ATM, FANCC
30colorectal cancer20.9PCNA, LMNA, XPA, XPC, ATR, ATM
31gastric cancer20.9PCNA, XPA, XPC, ATR, ATM, HMGA1
32prostatitis20.4RECQL4, PCNA, LMNA, XPC, ATM, HMGA1
33fanconi's anemia20.2PCNA, LMNA, XPA, XPC, ATR, ATM
34photosensitive trichthiodystrophy13.4XPA, XPC, ERCC4
35schimke immunoosseous dysplasia13.3XPA, XPC, ERCC4
36skin benign neoplasm13.3XPA, XPC, PTCH1
37neuronal ceroid-lipofuscinoses13.3CALB2, PVALB, PSAP
38dentatorubral-pallidoluysian atrophy13.2CALB2, TPH1, PVALB
39west syndrome13.1TPH1, PTCH1, PVALB
40cervical endometrioid adenocarcinoma13.1CALB2, TP53
41acoustic neuroma13.1PCNA, XPC, ERCC4
42adenoameloblastoma13.1PCNA, CALB2, PTCH1
43pigmented villonodular synovitis13.1CALB2, TP53
44cerebellar liponeurocytoma13.0TP53, PTCH1
45syringocystadenoma papilliferum13.0PCNA, PTCH1
46spitz nevus13.0PCNA, TP53
47focal cortical dysplasia13.0CALB2, TP53, PVALB
48ovarian germ cell tumor13.0PCNA, TP53
49ganglioglioma12.9CALB2, TP53, PVALB
50neuroma12.9PCNA, XPC, ERCC4

Graphical network of the top 20 diseases related to xeroderma pigmentosum, group a:



Graphical network of diseases related to xeroderma pigmentosum, group a

Clinical Features for Xeroderma Pigmentosum, Group a

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33OMIM
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Clinical features from OMIM: 278700

Drugs & Therapeutics for Xeroderma Pigmentosum, Group a

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4CenterWatch, 29NIH Clinical Center, 5ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Xeroderma Pigmentosum, Group a

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Anatomical Context for Xeroderma Pigmentosum, Group a

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22MalaCards
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MalaCards organs/tissues related to xeroderma pigmentosum, group a:

22
Brain, Skin, Lung

Phenotypes for genes affiliated with Xeroderma Pigmentosum, Group a

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25MGI
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MGI Mouse Phenotypes related to xeroderma pigmentosum, group a:

25 (show all 20)
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1endocrine/exocrine gland phenotypeMP:00053799.9XPA, PSAP, FANCC
2respiratory system phenotypeMP:00053889.6ATR, TPH1
3craniofacial phenotypeMP:00053829.4PTCH1, XPA, ATR, RECQL4
4skeleton phenotypeMP:00053908.5ATR, LMNA, TP53, PTCH1, PSAP, FANCC
5pigmentation phenotypeMP:00011868.5PTCH1, TP53, ATR, XPA, LMNA, PRKDC
6adipose tissue phenotypeMP:00053758.4TPH1, LMNA, XPA, ATR, TP53, PRKDC
7nervous system phenotypeMP:00036318.4CALB2, PRKDC, PVALB, LMNA, XPC, ATR
8digestive/alimentary phenotypeMP:00053818.2RECQL4, LMNA, PRKDC, TP53, PSAP, ATR
9liver/biliary system phenotypeMP:00053708.2SOD1, ERCC4, ATR, FANCC, TP53, PSAP
10integument phenotypeMP:00107717.9XPC, ATR, PTCH1, PRKDC, RECQL4, TPH1
11muscle phenotypeMP:00053697.9TP53, PTCH1, PVALB, PSAP, SOD1, XPA
12tumorigenesisMP:00020067.8TP53, XPC, XPA, RECQL4, ATR, ATM
13vision/eye phenotypeMP:00053917.7XPC, TP53, PTCH1, PSAP, PRKDC, LMNA
14mortality/agingMP:00107687.4XPA, LMNA, XPC, ATR, ATM, ERCC4
15growth/size phenotypeMP:00053786.6LMNA, PSAP, PRKDC, PTCH1, TPH1, TP53
16behavior/neurological phenotypeMP:00053866.4TPH1, XPC, TP53, CALB2, ATM, PVALB
17reproductive system phenotypeMP:00053896.3PTCH1, FANCC, PSAP, PCNA, XPA, ATR
18hematopoietic system phenotypeMP:00053975.9PTCH1, ATR, XPA, LMNA, PCNA, RECQL4
19immune system phenotypeMP:00053875.9PCNA, RECQL4, LMNA, ATR, ATM, HMGA1
20cellular phenotypeMP:00053845.7XPA, RPA1, ATM, PRKDC, SOD1, PCNA

Publications for genes affiliated with Xeroderma Pigmentosum, Group a

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35PubMed
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Articles related to xeroderma pigmentosum, group a:

(show all 40)
idTitleAuthorsYearAffiliating Genes
1XPA gene mutations resulting in subtle truncation of protein in xeroderma pigmentosum group A patients with mild skin symptoms. (20574439)Takahashi Y.... Moriwaki S.2010XPA
2Melanocyte-stimulating hormone directly enhances UV-I nduced DNA repair in keratinocytes by a xeroderma pigmentosum group A-dependent mechanism. (20388774)Dong L.... Cui R.2010XPA
3Involvement of xeroderma pigmentosum group A (XPA) in progeria arising from defective maturation of prelamin A. (17848622)Liu Y.... Zou Y.2008LMNA, XPA
4Polymorphisms of the DNA repair gene xeroderma pigmentosum groups A and C and risk of esophageal squamous cell carcinoma in a population of high incidence region of North China. (17653764)Guo W.... Dong X.J.2008XPC, XPA
5Oxidative damage induced genotoxic effects in human fibroblasts from Xeroderma Pigmentosum group A patients. (18585952)Low G.K.... Hande M.P.2008XPA
6RecQ4 facilitates UV light-induced DNA damage repair through interaction with nucleotide excision repair factor xeroderma pigmentosum group A (XPA). (18693251)Fan W.... Luo J.2008RECQL4
7High-mobility group A1 proteins inhibit expression of nucleotide excision repair factor xeroderma pigmentosum group A. (17616660)Adair J.E.... Reeves R.2007XPA, HMGA1
8Recognition of helical kinks by xeroderma pigmentosum group A protein triggers DNA excision repair. (16491090)Camenisch U.... Naegeli H.2006XPA
9Phosphorylation of nucleotide excision repair factor xeroderma pigmentosum group A by ataxia telangiectasia mutated and Rad3-related-dependent checkpoint pathway promotes cell survival in response to UV irradiation. (16540648)Wu X.... Zou Y.2006ATM, ATR, PRKDC
10Thermodynamic properties of damaged DNA and its recognition by xeroderma pigmentosum group A protein and replication protein A. (16405861)Brabec V.... KaspA!rkovA! J.2006RPA1
11Oxidative nucleotide damage and superoxide dismutase expression in the brains of xeroderma pigmentosum group A and Cockayne syndrome. (15626539)Hayashi M.... Fukatsu R.2005SOD1
12DNA-based prenatal diagnosis in a Chinese family with xeroderma pigmentosum group A. (15214909)Yang Y.... Zhu X.2004XPA
13Brainstem and basal ganglia lesions in xeroderma pigmentosum group A. (15535132)Hayashi M.... Tamagawa K.2004TPH1, CALB2, PVALB
14Xeroderma pigmentosum group A protein loads as a separate factor onto DNA lesions. (12897146)Rademakers S.... Vermeulen W.2003XPA
15Xeroderma pigmentosum group a protein and chemotherapy resistance in human germ cell tumors. (14563950)Honecker F.... Looijenga L.H.2003XPA
16Complementation of the DNA repair deficiency in human xeroderma pigmentosum group a and C cells by recombinant adenovirus-mediated gene transfer. (12396616)Muotri A.R.... Menck C.F.2002XPC
17Functional studies on the interaction between human replication protein A and Xeroderma pigmentosum group A complementing protein (XPA). (11911469)Lee B.E.... Kim D.K.2002XPA
18Polymorphisms of the DNA repair gene xeroderma pigmentosum group A and risk of primary lung cancer. (12376498)Park J.Y.... Jung T.H.2002XPA
19Polymorphisms in the human xeroderma pigmentosum group A gene and their impact on cell survival and nucleotide excision repair. (12509227)Mellon I.... States J.C.2002XPA
20Possible involvement of enhanced prostaglandin E2 production in the photosensitivity in xeroderma pigmentosum group A model mice. (10651981)Kuwamoto K.... Horio T.2000CPOX
21Functional studies on the interaction between human replication protein A and Xeroderma pigmentosum group A complementing protein (XPA). (10340474)Lee B.E.... Kim D.K.1999RPA1, RPA2, XPA
22Distribution of mutations in the human Xeroderma pigmentosum group A gene and their relationships to the functional regions of the DNA damage recognition protein. (9671271)States J.C.... Cleaver J.E.1998XPA
23Mutational analysis of a function of xeroderma pigmentosum group A (XPA) protein in strand-specific DNA repair. (9753735)Kobayashi T.... Tanaka K.1998XPA
24Mapping the multiple self-healing squamous epithelioma (MSSE) gene and investigation of xeroderma pigmentosum group A (XPA) and PATCHED (PTCH) as candidate genes. (9439661)Richards F.M.... Ferguson-Smith M.A.1997XPA, PTCH1, MSSE
25Effect of XPA gene mutations on UV-induced immunostaining of PCNA in fibroblasts from xeroderma pigmentosum group A patients. (8814338)Miura M.... Sasaki T.1996PCNA, XPA
26Preferential DNA damage in the p53 gene by benzo[a]pyrene metabolites in cytochrome P4501A1-expressing xeroderma pigmentosum group A cells. (8634092)Quan T.... States J.C.1996TP53
27Splice site mutations in a xeroderma pigmentosum group A patient with delayed onset of neurological disease. (8765158)States J.C.... Myrand S.P.1996XPA
28Correlation of the clinical manifestations and gene mutations of Japanese xeroderma pigmentosum group A patients. (7577588)Kondoh M.... Ichihashi M.1995XPA
29Human xeroderma pigmentosum group A protein interacts with human replication protein A and inhibits DNA replication. (7665601)Lee S.H.... Drissi R.1995RPA1, XPA, TOP1
30Expression of a transfected DNA repair gene (XPA) in xeroderma pigmentosum group A cells restores normal DNA repair and mutagenesis of UV-treated plasmids. (7614689)Levy D.D.... Kraemer K.H.1995XPA
31Analysis of cells harboring a putative DNA repair gene reveals a lack of evidence for a second independent xeroderma pigmentosum group A correcting gene. (7519740)Jones C.J.... Wood R.D.1994XPA
32A YAC contig spanning the nevoid basal cell carcinoma syndrome, Fanconi anaemia group C, and xeroderma pigmentosum group A loci on chromosome 9q. (7829076)Morris D.J.... Reis A.1994XPA, FANCC, PTCH1
33Preferential binding of the xeroderma pigmentosum group A complementing protein to damaged DNA. (8218288)Jones C.J.... Wood R.D.1993XPA
34High prevalence of the point mutation in exon 6 of the xeroderma pigmentosum group A-complementing (XPAC) gene in xeroderma pigmentosum group A patients in Tunisia. (8105686)Nishigori C.... Takebe H.1993XPA
35Molecular analysis of Xeroderma pigmentosum group A gene. (8504220)Tanaka K.1993XPA
36Yeast RAD14 and human xeroderma pigmentosum group A DNA-repair genes encode homologous proteins. (1741034)Bankmann M.... Prakash S.1992ERCC4
37Two types of proliferating cell nuclear antigen (PCNA) complex formation in quiescent normal and xeroderma pigmentosum group A fibroblasts following ultraviolet light (uv) irradiation. (1353458)Miura M.... Takasaki Y.1992PCNA
38Restoration of proliferating cell nuclear antigen (PCNA) complex formation in xeroderma pigmentosum group A cells following cis-diamminedichloroplatinum (II)-treatment by cell fusion with normal cells. (1354671)Miura M.... Takasaki Y.1992PCNA
39Mutational analysis of the structure and function of the Xeroderma pigmentosum group A complementing protein. Identification of essential domains for nuclear localization and DNA excision repair. (1601884)Miyamoto I.... Tanaka K.1992XPA
40Identification and characterization of xpac protein, the gene product of the human XPAC (Xeroderma pigmentosum group A complementing) gene. (1918083)Miura N.... Okada Y.1991XPA

Expression for genes affiliated with Xeroderma Pigmentosum, Group a

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1BioGPS
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Expression patterns in normal tissues for genes affiliated with Xeroderma Pigmentosum, Group a

Pathways for genes affiliated with Xeroderma Pigmentosum, Group a

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38Reactome, 20KEGG, 10EMD Millipore, 36QIAGEN, 41Thomson Reuters, 3Cell Signaling Technology
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Pathways related to xeroderma pigmentosum, group a according to GeneDecks:

(show all 30)
idPathwayScoreTop Affiliating Genes
1Dual incision reaction in GG-NER3810.1XPC, XPA, ERCC4
2Mismatch repair2010.0RPA2, RPA1, PCNA
3Transcription P53 signaling pathway109.9ATR, TP53
4DNA replication209.9PCNA, RPA1, RPA2
5Nucleotide Excision Repair Pathway369.6ERCC4, PCNA, XPA, XPC, RPA2
6G2/M DNA damage checkpoint389.5ATR, ATM
7Nucleotide excision repair209.5ERCC4, RPA2, RPA1, XPC, PCNA, XPA
8Fanconis Anaemia Pathway369.4ATR, ATM, FANCC
9DNA Damage Induced 14-3-3Sigma Signaling369.3ATR, ATM, TP53
10Cell cycle Role of 14-3-3 proteins in cell cycle regulation109.3ATR, TP53, ATM
11Cell cycle_Role of 14-3-3 proteins in cell cycle regulation419.2ATR, ATM, TP53
12p53 Signaling369.2ATM, TP53, ATR
13G1-S Phase Transition369.1ATR, ATM, TP53
14DNA damage_DNA-damage-induced responses419.1ATR, ATM, TP53, PRKDC
15DNA damage DNA-damage-induced responses109.1ATM, TP53, ATR, PRKDC
16GADD45 Pathway369.1ATR, ATM, TP53, PCNA
17G2-M Phase Transition369.1TP53, ATM, ATR
18p53 signaling pathway209.1TP53, ATR, ATM
19DNA damage ATM/ATR regulation of G1/S checkpoint109.0PCNA, ATR, TP53, ATM
20DNA Damage39.0RECQL4, ATR, RPA1, RPA2, PRKDC, TP53
21DNA damage_ATM/ATR regulation of G1/S checkpoint419.0ATR, PCNA, TP53, ATM
22Transcription_P53 signaling pathway419.0ATM, TP53, XPA, XPC, ATR
23Chks in Checkpoint Regulation369.0PCNA, TP53, ATR, ATM
24DNA damage Role of Brca1 and Brca2 in DNA repair108.9PCNA, XPC, ATR, ATM, TP53
25DNA damage_Role of Brca1 and Brca2 in DNA repair418.9PCNA, XPC, ATR, TP53, ATM
26BRCA1 Pathway368.9ATM, ATR, FANCC, TP53
27Cyclins and Cell Cycle Regulation368.8ATR, ATM, TP53
28Cell cycle208.7ATM, PCNA, PRKDC, ATR, TP53
29Cell Cycle / Checkpoint Control37.8RPA1, TP53, RPA2, ATM, ATR, PCNA
30DNA Repair Mechanisms367.4FANCC, ATM, ATR, XPA, PRKDC, TP53

Compounds for genes affiliated with Xeroderma Pigmentosum, Group a

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32Novoseek , 9DrugBank, 18HMDB, 42Tocris Bioscience, 34PharmGKB
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Compounds related to xeroderma pigmentosum, group a according to GeneDecks:

(show all 49)
idCompoundScoreTop Affiliating Genes
1cpds32 10.4XPA, RPA1
2cyanine32 10.3PVALB, CALB2
3dbds32 10.3HMGA1, RPA1
4h2o232 10.3RECQL4, TPH1, CPOX
5nitric oxide32 9 18 9 13.2CALB2, TPH1, CPOX
6psoralen32 10.2XPA, ERCC4
72-acetylaminofluorene32 10.1XPC, XPA
8adozelesin32 10.1RPA2, TP53
9cgk 73342 10.0ATR, ATM
10rpa 232 9.8RPA2, RPA1, PCNA, ATR
11glutamate32 9.8CALB2, PCNA, CPOX, PVALB
12benzo(a)pyrene32 9.8XPC, XPA, TP53
13choline32 9 18 9 12.7CALB2, PVALB, PSAP, TPH1, CPOX
14tempol32 9.6ATM, SOD1
15bpde32 9.6ATM, TP53, RPA1
16phosphatidylserine32 9 9 11.6PSAP, TOP1
17methylmethanesulfonate32 9.5TP53, RPA1, ATR, PCNA
18deoxyribonucleic acid32 9.4ATM, PCNA, LMNA
19peroxynitrite32 9.4CPOX, TPH1, SOD1
208-oxo-dg32 9.4TP53, SOD1, PCNA
21egcg32 9.4TOP1, SOD1
227-hydroxystaurosporine32 9 9 11.3TP53, RPA2, TOP1
23arginine32 9.3SOD1, PSAP, TPH1, HMGA1, CPOX
24wortmannin32 42 10.2XPC, PSAP, ATR, ATM, RPA2
25oxaliplatin32 34 9 9 12.2TP53, TOP1, XPA
26temozolomide32 9 9 11.2TOP1, TP53, PCNA
27thiourea32 9.1TOP1, SOD1
28polyacrylamide32 9.0TPH1, PVALB, ATM, RPA1
29oligonucleotide32 9.0PSAP, RPA2, RPA1, TP53, PCNA, XPA
30caffeine32 34 9 18 9 13.0TP53, PCNA, ATM, ATR, RPA2
31topotecan32 9 9 10.9TP53, ATM, TOP1
32iron32 18 9.8SOD1, ATM, TPH1, PVALB, CPOX
33paraffin32 8.8PCNA, ATM, CALB2, TP53, PVALB, PTCH1
34melphalan32 9 9 10.8TOP1, TP53, ERCC4, FANCC
35thymidylate32 8.7PCNA, RPA1, TOP1, ERCC4, TP53
36atp32 8.7RPA1, LMNA, XPA, XPC, ATM, PVALB
37adriamycin32 8.5TP53, TOP1, PRKDC, SOD1
385fluorouracil32 8.4TOP1, TP53, ERCC4, PCNA
39cytarabine32 34 9 9 11.3TP53, ATM, PCNA, ATR, TOP1
40estrogen32 8.3PCNA, ATM, PVALB, CALB2, HMGA1, TPH1
41aphidicolin32 8.2TOP1, ATM, RPA2, PCNA, TP53, ATR
42zinc32 18 9.1LMNA, XPA, SOD1, RPA1, PTCH1, CALB2
43etoposide32 42 9 9 11.0TOP1, RPA2, RPA1, TP53, ATM, ATR
44tyrosine32 7.9PSAP, PVALB, HMGA1, CALB2, ATM, ATR
45mitomycin c32 7.8TOP1, XPA, ATM, FANCC, ERCC4, TP53
46hydroxyurea32 9 9 9.8TP53, RPA2, RPA1, TOP1, ATM, ATR
47serine32 7.7LMNA, ATR, ATM, HMGA1, TP53, RPA2
48camptothecin32 42 9 9 10.6TOP1, RPA2, PCNA, ATR, TP53, RPA1
49cisplatin32 34 9 9 10.6TOP1, RPA1, PCNA, TPH1, TP53, ATM

GO Terms for genes affiliated with Xeroderma Pigmentosum, Group a

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12Gene Ontology
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Cellular components related to xeroderma pigmentosum, group a according to GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1DNA replication factor A complexGO:00566210.1RPA2, RPA1
2PML bodyGO:0166058.9RPA1, TP53, ATR, RPA2
3nucleoplasmGO:0056545.2PCNA, PRKDC, TOP1, RPA2, RPA1, TP53

Biological processes related to xeroderma pigmentosum, group a according to GeneDecks:

(show all 25)
idNameGO IDScoreTop Affiliating Genes
1DNA recombinase assemblyGO:00073010.2RPA2, RPA1
2nucleotide-excision repair, DNA gap fillingGO:00629710.1RPA2, RPA1, PCNA
3telomere maintenance via semi-conservative replicationGO:03220110.0PCNA, RPA2, RPA1
4telomere maintenance via recombinationGO:00072210.0PCNA, RPA1, RPA2
5DNA strand elongation involved in DNA replicationGO:00627110.0RPA2, RPA1, PCNA
6T cell lineage commitmentGO:0023609.8TP53, PRKDC
7positive regulation of cell agingGO:0903439.8LMNA, TP53
8transcription-coupled nucleotide-excision repairGO:0062839.8PCNA, RPA2, ERCC4, RPA1
9B cell lineage commitmentGO:0023269.8PRKDC, TP53
10nucleotide-excision repair, DNA damage removalGO:0007189.8ERCC4, RPA2, XPC, XPA, RPA1
11cellular response to gamma radiationGO:0714809.6ATM, ATR
12double-strand break repair via homologous recombinationGO:0007249.6RPA2, RPA1, ERCC4, ATM
13base-excision repairGO:0062849.5PCNA, HMGA1, TP53
14DNA replicationGO:0062609.5RECQL4, PCNA, ATR, RPA1, RPA2
15myeloid cell homeostasisGO:0022629.5FANCC, SOD1
16telomere maintenanceGO:0007239.5RPA1, PRKDC, ERCC4, PCNA, RPA2
17removal of superoxide radicalsGO:0194309.4FANCC, SOD1
18replicative senescenceGO:0903999.4ATR, ATM, TP53
19somitogenesisGO:0017569.3ATM, TP53, PRKDC
20peptidyl-serine phosphorylationGO:0181058.9ATR, ATM, PRKDC
21cell cycle checkpointGO:0000758.8RPA2, RPA1, TP53, ATM, ATR, XPC
22nucleotide-excision repairGO:0062898.5RPA2, TP53, PCNA, RPA1, ERCC4, FANCC
23double-strand break repairGO:0063028.4ATM, TP53, RPA1, RPA2, PRKDC, SOD1
24positive regulation of apoptotic processGO:0430658.4ATM, SOD1, PRKDC, TP53
25DNA repairGO:0062817.6PCNA, RPA1, PRKDC, RECQL4, XPA, XPC

Molecular functions related to xeroderma pigmentosum, group a according to GeneDecks:

(show all 7)
idNameGO IDScoreTop Affiliating Genes
1bubble DNA bindingGO:0004059.8XPC, RECQL4
2MutLalpha complex bindingGO:0324059.8ATR, PCNA
3single-stranded DNA bindingGO:0036979.7ERCC4, RPA2, XPC, RPA1
4damaged DNA bindingGO:0036849.7ERCC4, XPA, XPC
5DNA-dependent protein kinase activityGO:0046779.6PRKDC, ATM
6protein N-terminus bindingGO:0474859.0ATM, ERCC4, TP53, RPA2
7protein bindingGO:0055154.6ATR, RPA2, FANCC, ATM, HMGA1, ERCC4

Sources for Xeroderma Pigmentosum, Group a

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2CDC
11FMA
18HMDB
19ICD9CM
20KEGG
24MeSH
25MGI
27NCIt
28NDF-RT
31NINDS
32Novoseek
33OMIM
35PubMed
36QIAGEN
43UMLS
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