XPC
MCID: XRD019
MIFTS: 56

Xeroderma Pigmentosum, Group C (XPC) malady

Genetic diseases, Skin diseases, Fetal diseases, Cancer diseases, Rare diseases, Neuronal diseases, Eye diseases, Ear diseases categories

Summaries for Xeroderma Pigmentosum, Group C

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48OMIM, 34MalaCards
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MalaCards: Xeroderma Pigmentosum, Group C, also known as xeroderma pigmentosum, complementation group c, is related to xeroderma pigmentosum and cockayne syndrome. An important gene associated with Xeroderma Pigmentosum, Group C is XPC (xeroderma pigmentosum, complementation group C), and among its related pathways are Oncogene Induced Senescence and Inhibition of Ribosome Biogenesis by p14(ARF). The compounds cpds and phosphodiester have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and liver, and related mouse phenotypes are vision/eye and digestive/alimentary.

Description from OMIM:48 278720

Aliases & Classifications for Xeroderma Pigmentosum, Group C

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48OMIM, 50Orphanet, 63UMLS, 64UMLS via Orphanet, 60SNOMED-CT via Orphanet, 27ICD10 via Orphanet
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Classifications:



Characteristics (Orphanet epidemiological data):

50
xeroderma pigmentosum complementation group c:
Inheritance: Autosomal recessive; Prevalence: <1/1000000; Age of onset: Variable


Aliases & Descriptions:

xeroderma pigmentosum, group c 48
xeroderma pigmentosum, complementation group c 63
xeroderma pigmentosum complementation group c 50
xpc 50


External Ids:

UMLS via Orphanet64 C2752147
SNOMED-CT via Orphanet60 25784009
OMIM48 278720
ICD10 via Orphanet27 Q82.1

Related Diseases for Xeroderma Pigmentosum, Group C

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18GeneCards, 19GeneDecks
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Diseases in the Xeroderma Pigmentosum, Group a family:

Xeroderma Pigmentosum, Group B xeroderma pigmentosum, group c
Xeroderma Pigmentosum, Group G Xeroderma Pigmentosum, Group F
Xeroderma Pigmentosum, Group D

Diseases related to Xeroderma Pigmentosum, Group C via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 66)
idRelated DiseaseScoreTop Affiliating Genes
1xeroderma pigmentosum31.6RAD23B, ERCC5, RAD23A, DDB2, TP53, RECQL
2cockayne syndrome30.7ERCC5, RAD23B, XPC, DDB2, ERCC3, ERCC8
3melanoma30.6CDKN2A, ERCC5, XPC, MMP1, DDB2, MC1R
4hepatocellular carcinoma30.5ABCA1, TP73, XPC, CDKN2A, TP53
5lung cancer30.5ERCC3, DDB2, ERCC5, XPC, TP73, TP53
6lung adenocarcinoma30.4TP73, TP53, CDKN2A
7breast cancer30.3TP73, MC1R, MMP1, XPC, CDKN2A, ABCA1
8photosensitive trichothiodystrophy30.2ERCC3, ERCC5
9colorectal cancer30.2TP73, MMP1, TP53, CDKN2A, XPC
10li-fraumeni syndrome30.1TP53, CDKN2A
11bladder carcinoma29.8CDKN2A, XPC, TP53, TP73
12squamous cell carcinoma of the head and neck29.7TP53, MMP1, CDKN2A, TP73
13malignant glioma29.7ERCC3, TP73, CDKN2A, TP53
14prostate cancer29.7TP53, TP73, MC1R, ABCA1, XPC, ERCC5
15ovarian cancer10.4
16xpc-related xeroderma pigmentosum10.4
17nasopharyngitis10.4
18adenocarcinoma10.4
19testicular cancer10.4
20xeroderma pigmentosum, group d10.4
21gallbladder adenocarcinoma10.2
22leukemia10.2
23bladder cancer susceptibility10.2
24xeroderma pigmentosum, group e, ddb-negative subtype10.1XPC, DDB2
25esophagitis10.1
26myeloid leukemia10.1
27mutagen sensitivity10.1
28breast cancer susceptibility10.1
29lung cancer susceptibility10.1
30esophageal squamous cell carcinoma10.1
31actinic keratosis10.1TP53
32oropharyngeal cancer, adult10.0CDKN2A, TP53
33oligodendroglioma10.0CDKN2A, TP73
34nasopharynx carcinoma10.0TP53, CDKN2A
35bladder carcinoma in situ10.0XPC, CDKN2A, TP53
36cervical squamous cell carcinoma10.0CDKN2A, TP73
37basal cell carcinoma10.0TP53, MMP1, MC1R
38lung benign neoplasm10.0CDKN2A, XPC, TP53
39cervical intraepithelial neoplasia10.0CDKN2A, TP73
40anaplastic astrocytoma10.0CDKN2A, TP53, TP73
41papilloma10.0TP53, CDKN2A, TP73
42endometrial carcinoma9.9CDKN2A, TP53
43colorectal adenoma9.9
44sporadic breast cancer9.9
45barrett's esophagus9.9
46chronic myeloid leukemia9.9
47infertility9.9
48acute myeloid leukemia9.9
49azoospermia9.9
50adenoma9.9

Graphical network of the top 20 diseases related to Xeroderma Pigmentosum, Group C:



Diseases related to xeroderma pigmentosum, group c

Symptoms for Xeroderma Pigmentosum, Group C

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48OMIM
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Symptoms by clinical synopsis from OMIM:

278720

Clinical features from OMIM:

278720

Drugs & Therapeutics for Xeroderma Pigmentosum, Group C

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6CenterWatch, 43NIH Clinical Center, 7ClinicalTrials
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Approved drugs:

Search CenterWatch for Xeroderma Pigmentosum, Group C

Drug clinical trials:

Search ClinicalTrials for Xeroderma Pigmentosum, Group C

Search NIH Clinical Center for Xeroderma Pigmentosum, Group C

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Genetic Tests for Xeroderma Pigmentosum, Group C

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Anatomical Context for Xeroderma Pigmentosum, Group C

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34MalaCards
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MalaCards organs/tissues related to Xeroderma Pigmentosum, Group C:

34
Skin, Lung, Liver

Animal Models for Xeroderma Pigmentosum, Group C or affiliated genes

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38MGI
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Publications for Xeroderma Pigmentosum, Group C

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53PubMed
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Articles related to Xeroderma Pigmentosum, Group C:

(show top 50)    (show all 57)
idTitleAuthorsYear
1
Repair of UV photolesions in xeroderma pigmentosum group C cells induced by translational readthrough of premature termination codons. (24218596)
2013
2
Hydrogen/Deuterium Exchange Reflects Binding of Human Centrin 2 to Ca(2+) and Xeroderma Pigmentosum Group C Peptide: An Example of EX1 Kinetics. (23439742)
2012
3
Identification of a Functional In Vivo p53 Response Element in the Coding Sequence of the Xeroderma Pigmentosum Group C Gene. (23050045)
2012
4
Dissection of the xeroderma pigmentosum group C protein function by site-directed mutagenesis. (20649465)
2011
5
A prevalent mutation with founder effect in xeroderma pigmentosum group C from north Africa. (20054342)
2010
6
Dynamic two-stage mechanism of versatile DNA damage recognition by xeroderma pigmentosum group C protein. (19686765)
2010
7
Diagnosing xeroderma pigmentosum group C by immunohistochemistry. (19915453)
2010
8
p53 dysfunction by xeroderma pigmentosum group C defects enhance lung adenocarcinoma metastasis via increased MMP1 expression. (21056989)
2010
9
Correlation of polymorphisms in xeroderma pigmentosum group C to the risk of ovarian carcinoma]. (18785488)
2008
10
Xeroderma pigmentosum group C in a French Caucasian patient with multiple melanoma and unusual long-term survival. (18717677)
2008
11
Overexpression of matrix metalloproteinase 1 in dermal fibroblasts from DNA repair-deficient/cancer-prone xeroderma pigmentosum group C patients. (18469853)
2008
12
The xeroderma pigmentosum group C gene polymorphisms and genetic susceptibility of nasopharyngeal carcinoma. (17882560)
2008
13
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases. (18987743)
2008
14
Attenuated expression of xeroderma pigmentosum group C is associated with critical events in human bladder cancer carcinogenesis and progression. (17510383)
2007
15
Ubiquitylation-independent degradation of Xeroderma pigmentosum group C protein is required for efficient nucleotide excision repair. (17693435)
2007
16
Xeroderma pigmentosum group C gene expression is predominantly regulated by promoter hypermethylation and contributes to p53 mutation in lung cancers. (17325666)
2007
17
Xeroderma pigmentosum group C in an isolated region of Guatemala. (16990803)
2007
18
Deficient base excision repair of oxidative DNA damage induced by methylene blue plus visible light in xeroderma pigmentosum group C fibroblasts. (17573042)
2007
19
Structural, thermodynamic, and cellular characterization of human centrin 2 interaction with xeroderma pigmentosum group C protein. (17897675)
2007
20
The xeroderma pigmentosum group C protein complex and ultraviolet-damaged DNA-binding protein: functional assays for damage recognition factors involved in global genome repair. (16793369)
2006
21
Flexibility and plasticity of human centrin 2 binding to the xeroderma pigmentosum group C protein (XPC) from nuclear excision repair. (16533048)
2006
22
Assessment of 3 xeroderma pigmentosum group C gene polymorphisms and risk of cutaneous melanoma: a case-control study. (15731165)
2005
23
Characterisation of novel mutations in Cockayne syndrome type A and xeroderma pigmentosum group C subjects. (15744458)
2005
24
No association between three xeroderma pigmentosum group C and one group G gene polymorphisms and risk of cutaneous melanoma. (15494739)
2005
25
DNA-based diagnosis of xeroderma pigmentosum group C by Whole-genome scan using single-nucleotide polymorphism microarray. (15654957)
2005
26
Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. (15964821)
2005
27
Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex. (15336624)
2004
28
A novel regulation mechanism of DNA repair by damage-induced and RAD23-dependent stabilization of xeroderma pigmentosum group C protein. (12815074)
2003
29
Xeroderma pigmentosum group C protein interacts physically and functionally with thymine DNA glycosylase. (12505994)
2003
30
Efficient repair of cyclobutane pyrimidine dimers at mutational hot spots is restored in complemented Xeroderma pigmentosum group C and trichothiodystrophy/xeroderma pigmentosum group D cells. (12948486)
2003
31
Genetic correction of DNA repair-deficient/cancer-prone xeroderma pigmentosum group C keratinocytes. (12869216)
2003
32
Xeroderma pigmentosum group C protein possesses a high affinity binding site to human centrin 2 and calmodulin. (12890685)
2003
33
Cell cycle deregulation and xeroderma pigmentosum group C cell transformation. (12485438)
2002
34
p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene. (12242345)
2002
35
A stop codon in xeroderma pigmentosum group C families in Turkey and Italy: molecular genetic evidence for a common ancestor. (11511294)
2001
36
Centrosome protein centrin 2/caltractin 1 is part of the xeroderma pigmentosum group C complex that initiates global genome nucleotide excision repair. (11279143)
2001
37
The xeroderma pigmentosum group C protein complex XPC-HR23B plays an important role in the recruitment of transcription factor IIH to damaged DNA. (10734143)
2000
38
A new xeroderma pigmentosum group C poly(AT) insertion/deletion polymorphism. (11023539)
2000
39
Mutational inactivation of the xeroderma pigmentosum group C gene confers predisposition to 2-acetylaminofluorene-induced liver and lung cancer and to spontaneous testicular cancer in Trp53-/- mice. (10029060)
1999
40
Xeroderma pigmentosum group C protein complex is the initiator of global genome nucleotide excision repair. (9734359)
1998
41
Characterization of the properties of a human homologue of Escherichia coli RecQ from xeroderma pigmentosum group C and from HeLa cells. (8790942)
1996
42
Purification and cloning of a nucleotide excision repair complex involving the Xeroderma pigmentosum group C protein and a human homologue of yeast RAD23. (8168482)
1994
43
Assignment of xeroderma pigmentosum group C (XPC) gene to chromosome 3p25. (8088800)
1994
44
Repair in ribosomal RNA genes is deficient in xeroderma pigmentosum group C and in Cockayne's syndrome cells. (7512688)
1994
45
Characterization of molecular defects in Xeroderma pigmentosum group C. (8298653)
1993
46
Expression cloning of a human DNA repair gene involved in Xeroderma pigmentosum group C. (1522891)
1992
47
Expression cloning of a human DNA repair gene involved in xeroderma pigmentosum group C. (1461286)
1992
48
Radiation-induced chromatid aberrations in Cockayne syndrome and xeroderma pigmentosum group C fibroblasts in relation to cancer predisposition. (1756475)
1991
49
Isolation by polymerase chain reaction of a cDNA whose product partially complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells. (2332174)
1990
50
An immortalized xeroderma pigmentosum, group C, cell line which replicates SV40 shuttle vectors. (3029584)
1987

Variations for Xeroderma Pigmentosum, Group C

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65UniProtKB/Swiss-Prot, 1 National Center for Biotechnology Information (Clinvar), 8dbSNP
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UniProtKB/Swiss-Prot genetic disease variations for Xeroderma Pigmentosum, Group C:

65
id Symbol AA change Variation ID SNP ID
1XPCp.Pro334HisVAR_005846rs74737358
2XPCp.Trp690SerVAR_064039

Clinvar genetic disease variations for Xeroderma Pigmentosum, Group C:

1
id Gene Name Type Significance SNP ID Assembly Location
1XPCNM_004628.4(XPC): c.1001C> A (p.Pro334His)single nucleotide variantPathogenicrs74737358GRCh37Chr 3, 14200382: 14200382
2XPCXPC, 83-BP INS, NT462insertionPathogenic
3XPCXPC, 3-BP INS, GGT, CODON 580 AND LYS822GLNinsertionPathogenic
4XPCXPC, 2-BP DEL, 1132AAdeletionPathogenic
5XPCXPC, IVS9DS, T-G, +2single nucleotide variantPathogenic
6XPCXPC, 2-BP DEL, 669ATdeletionPathogenic
7XPCNM_004628.4(XPC): c.1735C> T (p.Arg579Ter)single nucleotide variantPathogenicrs121965088GRCh37Chr 3, 14199648: 14199648
8XPCXPC, IVS3AS, T-A, -9single nucleotide variantPathogenic
9XPCXPC, IVS3AS, A-G, -24single nucleotide variantPathogenic
10XPCXPC, 2-BP DEL, 1744TGdeletionPathogenic

Expression for genes affiliated with Xeroderma Pigmentosum, Group C

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2BioGPS, 16Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Xeroderma Pigmentosum, Group C

Search GEO for disease gene expression data for Xeroderma Pigmentosum, Group C.

Pathways for genes affiliated with Xeroderma Pigmentosum, Group C

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Sources:
51PathCards, 56Reactome, 54QIAGEN, 61Thomson Reuters, 39NCBI BioSystems Database, 31KEGG, 5Cell Signaling Technology
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Pathways related to Xeroderma Pigmentosum, Group C according to GeneCards/GeneDecks:

(show all 16)
idSuper pathways (with members indented)ScoreTop Affiliating Genes
19.7TP53, CDKN2A
29.7CDKN2A, TP53
39.6DDB2, TP53, XPC
49.5TP73, DDB2, TP53
59.5TP53, GTF2H1, CDKN2A
6
Show member pathways
DNA damage response (only ATM dependent)39
Wnt Signaling Pathway and Pluripotency39
9.4TP53, CDKN2A, TP73
7
Show member pathways
Apoptosis Modulation and Signaling39
Apoptosis39
9.4CDKN2A, TP53, TP73
8
Show member pathways
9.4CDKN2A, TP53, TP73
9
Show member pathways
Signaling Pathways in Glioblastoma39
9.3CDKN2A, TP53, MMP1
109.2TP53, UVRAG, CDKN2A
11
Show member pathways
DNA damage response39
9.2TP53, CDKN2A, TP73, DDB2
12
Show member pathways
8.9ERCC3, GTF2H1, TP53, RAD23B, ERCC5, XPC
138.5TP53, XPC, ERCC3, GTF2H1, TDG, CDKN2A
14
Show member pathways
8.3DDB2, ERCC8, TDG, GTF2H1, ERCC3, ERCC5
15
Show member pathways
7.7DDB2, XPC, RAD23B, ERCC5, ERCC8, GTF2H1
16
Show member pathways
7.4XPC, UVRAG, RECQL, TP73, TP53, DDB2

Compounds for genes affiliated with Xeroderma Pigmentosum, Group C

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46Novoseek, 12DrugBank, 25HMDB, 52PharmGKB, 62Tocris Bioscience, 30IUPHAR
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Compounds related to Xeroderma Pigmentosum, Group C according to GeneCards/GeneDecks:

(show all 33)
idCompoundScoreTop Affiliating Genes
1cpds4610.4DDB2, ERCC3
2phosphodiester4610.2ERCC3, ERCC5
3acnu4610.1TP53, CDKN2A
4hpvs4610.0CDKN2A, TP53
5geranylgeranyl pyrophosphate4610.0ABCA1, MMP1
6olomoucine46 1210.9CDKN2A, TP53
7temozolomide46 1210.9TP53, CDKN2A
8tetracycline46 1210.8CDKN2A, MMP1, TP73
9aflatoxin b146 2510.8TP53, CDKN2A
10o6-methylguanine469.8CDKN2A, TP73, TP53
11hmba469.8TP53, CDKN2A
12vincristine46 52 1211.7TP53, TP73, CDKN2A
13adriamycin469.7CDKN2A, TP73, TP53
14camptothecin46 62 1211.7TP53, TP73, CDKN2A
15bcnu469.7CDKN2A, TP53
16egcg469.7CDKN2A, MMP1, TP53
175-aza-2deoxycytidine469.6TP53, TP73, CDKN2A
18arsenite46 2510.6CDKN2A, MMP1, TP53
195-methylcytosine46 2510.6TP53, TDG, CDKN2A
20noxa469.5TP73, TP53
21doxorubicin46 52 1211.4TP53, TP73, MMP1, CDKN2A
22paraffin469.4CDKN2A, MMP1, TP73, TP53
235fluorouracil469.2CDKN2A, TDG, TP73, TP53
24cycloheximide469.2CDKN2A, MMP1, TP53, ABCA1
25guanine46 25 1211.1TP53, MMP1, TDG
26progesterone46 30 62 25 1213.1CDKN2A, MMP1, TP73, TP53, ABCA1
27h2o2469.1CDKN2A, MMP1, MC1R, TP53
28retinoic acid46 2510.0ABCA1, TP53, TP73, MMP1, CDKN2A
29proline469.0ABCA1, TP53, TP73, RAD23A, RAD23B
30cisplatin46 52 62 1211.9CDKN2A, DDB2, TP53, TP73, XPC, ERCC5
31estrogen468.8TP53, TP73, MMP1, TDG, CDKN2A
32oligonucleotide468.7ABCA1, TP53, TP73, MMP1, XPC, ERCC5
33atp46 309.1ABCA1, RECQL, XPC, ERCC5, ERCC3, TDG

GO Terms for genes affiliated with Xeroderma Pigmentosum, Group C

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17Gene Ontology
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Cellular components related to Xeroderma Pigmentosum, Group C according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1holo TFIIH complexGO:0056759.7ERCC5, ERCC3, GTF2H1
2nuclear bodyGO:0166049.7CDKN2A, TP53
3XPC complexGO:0719429.7CETN2, XPC, RAD23B
4protein complexGO:0432348.7DDB2, TP53, UVRAG, ERCC8, CDKN2A
5nucleoplasmGO:0056547.7CDKN2A, DDB2, TP53, XPC, RAD23B, ERCC5
6nucleolusGO:0057306.6TP53, RECQL, XPC, RAD23A, RAD23B, ERCC5
7nucleusGO:0056345.7TP53, TP73, RECQL, XPC, RAD23A, RAD23B

Biological processes related to Xeroderma Pigmentosum, Group C according to GeneCards/GeneDecks:

(show all 32)
idNameGO IDScoreTop Affiliating Genes
1nucleotide-excision repair, DNA damage recognitionGO:00071510.4XPC, RAD23B
2regulation of mitotic cell cycle phase transitionGO:190199010.4ERCC3, XPC
3transcription elongation from RNA polymerase I promoterGO:00636210.3ERCC3, GTF2H1
4termination of RNA polymerase I transcriptionGO:00636310.2ERCC3, GTF2H1
5transcription initiation from RNA polymerase I promoterGO:00636110.2GTF2H1, ERCC3
6mitotic G1 DNA damage checkpointGO:03157110.1TP73, TP53
7UV protectionGO:00965010.1MC1R, ERCC5, ERCC3
8DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGO:00697810.1TP73, TP53
9replicative senescenceGO:09039910.0TP53, CDKN2A
10transcription from RNA polymerase I promoterGO:00636010.0ERCC3, GTF2H1
11regulation of proteasomal ubiquitin-dependent protein catabolic processGO:03243410.0RAD23B, RAD23A
12positive regulation of cell cycle arrestGO:07115810.0CDKN2A, TP53
13release of cytochrome c from mitochondriaGO:0018369.9TP73, TP53
14protein polyubiquitinationGO:0002099.9CDKN2A, ERCC8, DDB2
15mismatch repairGO:0062989.9TDG, TP73
16response to X-rayGO:0101659.9ERCC8, TP73, TP53
17response to UVGO:0094119.9DDB2, ERCC5, ERCC8, ERCC3
18response to gamma radiationGO:0103329.9TP53, TP73
19transcription-coupled nucleotide-excision repairGO:0062839.9GTF2H1, ERCC3, ERCC8, ERCC5
20intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGO:0427719.8TP73, TP53
21protein tetramerizationGO:0512629.8TP73, TP53
22cellular response to DNA damage stimulusGO:0069749.7ERCC8, TP73, TP53
23proteasome-mediated ubiquitin-dependent protein catabolic processGO:0431619.7ERCC8, RAD23B, RAD23A
247-methylguanosine mRNA cappingGO:0063709.7ERCC3, GTF2H1
25cell cycle arrestGO:0070509.7TP53, TP73, CDKN2A
26cellular response to UVGO:0346449.7TP73, TP53
27DNA strand renaturationGO:0007339.6TP53, RECQL
28nucleotide-excision repair, DNA damage removalGO:0007189.5DDB2, XPC, RAD23B, ERCC5, ERCC3, GTF2H1
29positive regulation of transcription from RNA polymerase II promoterGO:0459449.0TP53, TP73, MC1R, ERCC3, GTF2H1, CDKN2A
30viral processGO:0160329.0TP53, MMP1, RAD23A, ERCC3, GTF2H1
31nucleotide-excision repairGO:0062897.7ERCC8, ERCC5, RAD23B, RAD23A, XPC, CETN2
32DNA repairGO:0062817.4TDG, DDB2, GTF2H1, ERCC3, ERCC8, ERCC5

Molecular functions related to Xeroderma Pigmentosum, Group C according to GeneCards/GeneDecks:

(show all 14)
idNameGO IDScoreTop Affiliating Genes
1bubble DNA bindingGO:00040510.2ERCC5, XPC
2RNA polymerase II carboxy-terminal domain kinase activityGO:00835310.0ERCC3, GTF2H1
3DNA-dependent ATPase activityGO:00809410.0GTF2H1, ERCC3, ERCC8
4MDM2/MDM4 family protein bindingGO:0973719.9CDKN2A, TP53
5protein N-terminus bindingGO:0474859.7ERCC3, ERCC5, TP53
6p53 bindingGO:0020399.6TP53, TP73, CDKN2A
7double-stranded DNA bindingGO:0036909.5TDG, ERCC5, TP73
8single-stranded DNA bindingGO:0036979.4XPC, RAD23A, RAD23B, ERCC5
9ATP-dependent DNA helicase activityGO:0040039.4ERCC3, RECQL
10polyubiquitin bindingGO:0315939.3RAD23B, RAD23A
11DNA helicase activityGO:0036789.3ERCC8, RECQL
12transcription factor bindingGO:0081349.3TP53, TP73, ERCC3, CDKN2A
13damaged DNA bindingGO:0036848.0TDG, DDB2, TP53, TP73, XPC, RAD23A
14protein bindingGO:0055154.5CETN2, RECQL, MC1R, TP73, TP53, ABCA1

Products for genes affiliated with Xeroderma Pigmentosum, Group C

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4CDC
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27ICD10 via Orphanet
28ICD9CM
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