MCID: YCH001
MIFTS: 27

Y Chromosome Infertility malady

Genetic diseases, Rare diseases, Reproductive diseases categories

Aliases & Classifications for Y Chromosome Infertility

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Aliases & Descriptions for Y Chromosome Infertility:

Name: Y Chromosome Infertility 21 45 22 23 65
Male Sterility Due to Y-Chromosome Deletions 45 65
Y Chromosome-Related Azoospermia 22 23
Spermatogenic Failure, Y-Linked 23
Y Chromosome Microdeletions 45
 
Y Chromosome Deletions 65
Deleted in Azoospermia 45
Y Chromosome Deletion 22
Oligozoospermia 22
Daz 45


Classifications:



Summaries for Y Chromosome Infertility

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NIH Rare Diseases:45 Y chromosome infertility is a condition that affects the production of sperm, making it difficult or impossible for affected men to father children. an affected man's body may produce no sperm cells (azoospermia), a smaller than usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly. this condition accounts for between 5 percent and 10 percent of cases of azoospermia or severe oligospermia. as its name suggests, this form of infertility is caused by changes in the y chromosome, one of the sex chromosomes. y chromosome infertility is usually caused by deletions of genetic material in regions of the y chromosome called azoospermia factor (azf) a, b, or c. genes in these regions are believed to provide instructions for making proteins involved in sperm cell development, although the specific functions of these proteins are not well understood. in rare cases, changes to a single gene called usp9y, which is located in the azfa region of the y chromosome, can cause y chromosome infertility. some men with y chromosome infertility who have mild to moderate oligospermia may eventually father a child naturally. assisted reproductive technologies may help other affected men. because y chromosome infertility impedes the ability to father children, this condition is usually caused by new deletions on the y chromosome and occurs in men with no history of the disorder in their family. when men with y chromosome infertility do father children, either naturally or with the aid of assisted reproductive technologies, they pass on the genetic changes on the y chromosome to all their sons. as a result, the sons will also have y chromosome infertility. last updated: 3/7/2013

MalaCards based summary: Y Chromosome Infertility, also known as male sterility due to y-chromosome deletions, is related to azoospermia and spermatogenic failure, y-linked, 1, and has symptoms including azoospermia, y-linked inheritance and abnormality of metabolism/homeostasis. An important gene associated with Y Chromosome Infertility is USP9Y (Ubiquitin Specific Peptidase 9, Y-Linked).

Genetics Home Reference:23 Y chromosome infertility is a condition that affects the production of sperm, making it difficult or impossible for affected men to father children. An affected man's body may produce no sperm cells (azoospermia), a smaller than usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly.

Wikipedia:68 Y chromosome microdeletion (YCM) is a family of genetic disorders caused by missing gene(s) in the Y... more...

GeneReviews summary for yci

Related Diseases for Y Chromosome Infertility

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Diseases related to Y Chromosome Infertility via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 49)
idRelated DiseaseScoreTop Affiliating Genes
1azoospermia31.4DAZ1, DDX3Y, USP9Y
2spermatogenic failure, y-linked, 110.6
3gonadal dysgenesis10.4
4male infertility10.4
5oligospermia10.4
6partial deletion of y10.3
7spermatogenic failure, y-linked, 210.3
8smith-magenis syndrome10.2
9chromosomal disease10.2
10gonadal disease10.2
11hermaphroditism10.2
12reproductive system disease10.2
13sexual disorder10.2
14y chromosome detection10.2
1546,xy partial gonadal dysgenesis10.2
16rheumatoid arthritis10.2
17sertoli cell-only syndrome10.2
18infertility10.2
19spermatogenic failure 1110.2
20varicocele10.2
21alzheimer disease10.1
22cryptorchidism10.1
23chromophobe renal cell carcinoma10.1
24klinefelter's syndrome10.1
25hypospadias10.1
26turner syndrome10.1
27obesity10.0
28hyperprolactinemia10.0
29cystic fibrosis10.0
30spermatogenic failure 810.0
31spermatogenic failure 1210.0
32spermatogenic failure 1410.0
33spermatogenic failure 1310.0
34kallmann syndrome10.0
35male reproductive system disease10.0
36spinocerebellar ataxia10.0
37testicular disease10.0
38male genital disorders10.0
39spastic paraplegia epilepsy mental retardation10.0
40ataxia10.0
41spastic paraplegia - epilepsy - intellectual disability10.0
42severe combined immunodeficiency10.0DAZ1, DDX3Y, USP9Y
43deafness, y-linked 19.9DAZ1, DAZ2, DAZ3, USP9Y
44posterior foramen magnum meningioma9.8DAZ1, DAZ2, DDX3Y, USP9Y
45male urethral cancer9.8CDY1, DAZ1, DAZ2, DDX3Y, USP9Y
46partial duplication of the short arm of chromosome x9.7DAZ1, DAZ2, DAZ3, DDX3Y, RBMY1A1, USP9Y
47malignant glioma9.7DAZ1, DAZ2, DAZ3, DDX3Y, RBMY1A1, USP9Y
48scleromalacia perforans9.6DAZ1, DAZ2, DAZ3, DDX3Y, HSFY1, RBMY1A1
49zap70-related severe combined immunodeficiency7.9BPY2, CDY1, CDY2A, DAZ1, DAZ2, DAZ3

Graphical network of the top 20 diseases related to Y Chromosome Infertility:



Diseases related to y chromosome infertility

Symptoms for Y Chromosome Infertility

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HPO human phenotypes related to Y Chromosome Infertility:

id Description Frequency HPO Source Accession
1 azoospermia HP:0000027
2 y-linked inheritance HP:0001450
3 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Y Chromosome Infertility

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Drugs for Y Chromosome Infertility (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

idNameStatusPhaseClinical TrialsCas NumberPubChem Id
1
IsotretinoinapprovedPhase 21104759-48-25538, 5282379
Synonyms:
(13-cis)-Retinoate
(13-cis)-Retinoic acid
(13cis)-retinoic acid
(2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
(2Z,4E6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
(7E,9E,11E,13Z)-retinoic acid
(7e,9e,11e,13Z)-Retinoic acid
13 Cis-Retinoic Acid
13 cis retinoic acid
13-RA
13-cis RA
13-cis retinoic acid
13-cis-Retinoate
13-cis-Retinoic acid
13-cis-Vitamin A acid
13-cis-Vitamin a acid
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic acid
4-09-00-02388 (Beilstein Handbook Reference)
4759-48-2
97950-17-9
AC-15388
AC1NQZZ4
Absorica
Accutane
Accutane (TN)
Ambap302-79-4
Amnesteem
BML2-E07
BPBio1_000080
BRD-K76723084-001-05-9
BRN 1885770
BSPBio_000072
BSPBio_001331
BSPBio_003345
CCRIS 4286
CHEBI:6067
CHEMBL547
CID5282379
CIP-Isotretinoin
CPD000471891
Claravis
Clarus
D00348
D015474
EINECS 225-296-0
EU-0101081
Epuris
HMS1361C13
HMS1568D14
HMS1791C13
HMS1921D08
HMS1989C13
HMS2092N07
HSDB 3929
IDI1_033801
Isotane
Isotretinoin
Isotretinoin (USP)
 
Isotretinoin Retinoic acid
Isotretinoin Zinc Salt, 13 cis Isomer
Isotretinoin Zinc Salt, 13-cis-Isomer
Isotretinoin [USAN:BAN:INN]
Isotretinoin [USAN:INN:BAN]
Isotretinoina
Isotretinoine
Isotretinoine [INN-French]
Isotretinoino
Isotretinoino [INN-Spanish]
Isotretinoinum
Isotretinoinum [INN-Latin]
Isotrex
LMPR01090021
LS-143465
Lopac0_001081
MLS001074662
MolPort-003-666-394
Myorisan
NCGC00094358-01
NCGC00094358-02
NCGC00094358-03
NCGC00094358-04
NCGC00094358-05
NCGC00094358-06
NCGC00094358-07
NCGC00094358-08
NCGC00094358-09
NCGC00094358-13
Neovitamin A acid
Neovitamin a acid
Prestwick2_000256
Prestwick3_000256
Prestwick_642
R 3255
R3255_SIGMA
Retinoate
Retinoic acid
Ro 4 3780
Ro 4-3780
Ro 43780
Ro-4-3780
Ro-43780
Roaccutan
Roaccutane
Roacutan
SAM002548955
SMR000471891
SPECTRUM1502013
Sotret
Sotret (TN)
Spectrum5_001795
Spectrum5_001937
Teriosal
UNII-EH28UP18IF
Zenatane
cis-RA
cis-Retinoate
cis-Retinoic acid
isotretinoino
2
Tretinoinapproved, investigational, nutraceuticalPhase 2200302-79-45538, 444795, 444795, 5538
Synonyms:
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
(all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
(all-e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
.beta.-Retinoic acid
13497-05-7 (hydrochloride salt)
15-Apo-beta-caroten-15-oic acid
187175-63-9
1n4h
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoate
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid
3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)-2,4,6,8-nonatetraenoic acid (ecl)
302-79-4
5300-03-8
56573-65-0
7005-78-9
9(Z)-Retinoic acid
9-cis-RA
A-Acido (Argentina)
A-Vitaminsyre
A-Vitaminsyre [Denmark]
AC-6824
AC1L9GWO
AC1Q1J2J
AGN 100335
AGN 192013
AKOS000280845
ALRT 1057
AT-RA
ATRA
Aberel
Aberela
Aberela [Norway]
Accutane
Accutane Roche
Acid A Vit (Belgium, Netherlands)
Acid, Retinoic
Acid, Vitamin A
Acid, all-trans-Retinoic
Acid, beta-all-trans-Retinoic
Acid, trans-Retinoic
Acide retinoique (French)
Acide retinoique (French) (DSL)
Acide retinoique (french) (dsl)
Acnavit
Acnavit [Denmark]
Airol
Aknefug
Aknoten
Alitretinoin
All Trans Retinoic Acid
All Trans-Retinoic Acid
All-(E)-Retinoate
All-(E)-Retinoic acid
All-trans Retinoic Acid
All-trans-Retinoate
All-trans-Retinoic acid
All-trans-Tretinoin
All-trans-Vitamin A acid
All-trans-Vitamin A1 acid
Alltrans-retinoic acid
Amnesteem
Atra-IV
Atragen
Atralin
Avita
Avita (TN)
Avita Gel
Avitoin
Avitoin [Norway]
BAL4079
BIDD:GT0483
BIDD:PXR0081
BML2-E05
BPBio1_000082
BRN 2057223
BSPBio_000074
BSPBio_001500
Betarretin
C00777
CCRIS 3294
CCRIS 7098
CHEBI:15367
CHEMBL38
CID444795
CPD000058245
Claravis
Cordes VAS [Germany]
Cordes vas
D00094
D014212
DB00523
DB00755
DB00982
Dermairol
EINECS 206-129-0
EU-0101061
Effederm
Effederm [France]
Epi-aberel
Eudyna
HMS1361K22
HMS1568D16
HMS1791K22
HMS1921D14
HMS1989K22
HMS2089D20
HMS2092N11
HMS502N05
HSDB 2169
HSDB 7186
I04-0008
I14-2351
IDI1_000903
IDI1_033970
Isotretinoin Retinoic acid
L000833
LGD 100057
LMPR01090019
LS-1154
Lopac0_001061
Lsotretinoin
MLS000028588
MLS001076515
MLS002207234
MLS002222211
MolPort-000-883-857
NCGC00017280-06
NCGC00017280-17
 
NCGC00021808-04
NCGC00021808-05
NCGC00021808-06
NCGC00021808-07
NCGC00021808-09
NCGC00021808-14
NCGC00021808-15
NSC 122758
NSC-122758
NSC122758
Nexret
Obagi
PDT-002-002
Panretin Gel
Panretyn
Potassium Salt, Tretinoin
Prestwick2_000257
Prestwick3_000257
Prestwick_424
R 2625
R0064
R2625_SIGMA
REA
RETINOIC ACID, ALL TRANS
RETINOIC acid
Refissa
Renova
Renova (TN)
Retacnyl
Retin A
Retin A (TN)
Retin-A
Retin-A Micro
Retin-a
Retin-a Micro
Retinoate
Retinoic acid
Retinoic acid, all-trans- (8CI)
Retinova
Retionic Acid
Retionic acid
Retisol-A
Retisol-a
Ro 1-5488
S1653_Selleck
SAM002264647
SMR000058245
SPECTRUM1502016
SR-01000000239
SR-01000000239-14
ST057075
Salt, Tretinoin Potassium
Salt, Tretinoin Sodium
Salt, Tretinoin Zinc
Sodium Salt, Tretinoin
Solage
Sotret
Spectrum5_001746
Spectrum5_001933
Stieva-A
Stieva-a
Stieva-a Forte
TRETINON
Tretin M
Tretin m
Tretin-x
Tretin.x
Tretinoin
Tretinoin (JAN/USP/INN)
Tretinoin (TN)
Tretinoin 0.1% cream or placebo
Tretinoin Cream
Tretinoin Gel Microsphere
Tretinoin Potassium Salt
Tretinoin Sodium Salt
Tretinoin Zinc Salt
Tretinoin [USAN:INN:BAN]
Tretinoin/All-Trans Retinoic Acid
Tretinoina
Tretinoina [INN-Spanish]
Tretinoine
Tretinoine (French)
Tretinoine (french) (einecs)
Tretinoine [INN-French]
Tretinoino
Tretinoino [INN-Spanish]
Tretinoinum
Tretinoinum [INN-Latin]
Tretinx
Tri-Luma
Trétinoïne
UNII-1UA8E65KDZ
UNII-5688UTC01R
UPCMLD-DP097
Vesanoid
Vesanoid (TN)
Vesanoid, Airol, Renova, Atralin, Retin-A, Avita, Tretinoin
Vesnaroid
Vitamin A acid
Vitinoin
WLN: L6UTJ A1 B1U1Y1 & U2U1Y1 & U1VQ C1 C1
WLN: L6UTJ A1 B1U1Y1&U2U1Y1&U1VQ C1 C1
Zinc Salt, Tretinoin
[3H]Retinoic acid
all trans-Retinoic acid
all-(E)-Retinoic acid
all-(e)-Retinoic acid
all-trans-Retinoic acid
all-trans-Tretinoin
all-trans-Vitamin A acid
all-trans-Vitamin A1 acid
all-trans-Vitamin a acid
all-trans-Vitamin a1 acid
all-trans-b-Retinoic acid
all-trans-beta-Retinoic acid
b-Retinoic acid
beta all trans Retinoic Acid
beta-Ra
beta-Retinoate
beta-Retinoic Acid
beta-Retinoic acid
beta-all-trans-Retinoic acid
bmse000562
nchembio.154-comp2
trans Retinoic Acid
trans-Retinoate
trans-Retinoic acid
tretinoin
tretinoin liposome
tretinoine (French) (EINECS)
3Calcium, Dietary3529

Interventional clinical trials:

idNameStatusNCT IDPhase
1Preimplantation Genetic Diagnosis for the Indication of Advanced Reproductive AgeSuspendedNCT00646893Phase 4
2RA-2 13-cis Retinoic Acid (Isotretinoin)RecruitingNCT02061384Phase 2
3Genetic Studies Spermatogenic FailureCompletedNCT00548977
4The Clinical Study of Sex Chromosome VariantsRecruitingNCT01661010
5Relationship Between Sperm Head Vacuoles and Sperm DNA Alterations in Infertile MenRecruitingNCT02006446
6Effect of Trophectoderm Biopsy for Sex Selection on the Pregnancy and Miscarriage Rates of Women Undergoing IVF/ICSIActive, not recruitingNCT02412605
7X-chromosome Inactivation, Epigenetics and the TranscriptomeActive, not recruitingNCT01678261
8Aneuploidies in Embryos and Spermatozoa From Patients With Y-chromosome MicrodeletionsNot yet recruitingNCT02527954

Search NIH Clinical Center for Y Chromosome Infertility

Genetic Tests for Y Chromosome Infertility

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Genetic tests related to Y Chromosome Infertility:

id Genetic test Affiliating Genes
1 Y Chromosome Infertility22 USP9Y

Anatomical Context for Y Chromosome Infertility

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Animal Models for Y Chromosome Infertility or affiliated genes

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Publications for Y Chromosome Infertility

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Articles related to Y Chromosome Infertility:

idTitleAuthorsYear
1
Y Chromosome Infertility (20301513)
1993

Variations for Y Chromosome Infertility

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Expression for genes affiliated with Y Chromosome Infertility

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Search GEO for disease gene expression data for Y Chromosome Infertility.

Pathways for genes affiliated with Y Chromosome Infertility

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GO Terms for genes affiliated with Y Chromosome Infertility

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Cellular components related to Y Chromosome Infertility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1nucleusGO:00056346.5BPY2, CDY1, CDY2A, DAZ1, DAZ2, DAZ3

Biological processes related to Y Chromosome Infertility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1single fertilizationGO:00073389.5BPY2, DAZ2, XKRY
2histone acetylationGO:00165739.4CDY1, CDY2A
3spermatogenesisGO:00072837.7BPY2, CDY1, CDY2A, DAZ1, DAZ2, DAZ3

Molecular functions related to Y Chromosome Infertility according to GeneCards Suite gene sharing:

idNameGO IDScoreTop Affiliating Genes
1histone acetyltransferase activityGO:00044029.6CDY1, CDY2A
2nucleotide bindingGO:00001669.4DAZ1, DAZ2, DAZ3, RBMY1A1
3RNA bindingGO:00037239.0DAZ1, DAZ2, DAZ3, DDX3Y, RPS4Y2
4nucleic acid bindingGO:00036768.7DAZ1, DAZ2, DAZ3, DDX3Y, RBMY1A1

Sources for Y Chromosome Infertility

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2CDC
14ExPASy
15FDA
16FMA
24GTR
25HGMD
26HMDB
27ICD10
28ICD10 via Orphanet
29ICD9CM
30IUPHAR
31KEGG
34MedGen
36MeSH
37MESH via Orphanet
38MGI
41NCI
42NCIt
43NDF-RT
46NINDS
47Novoseek
49OMIM
50OMIM via Orphanet
54PubMed
55QIAGEN
60SNOMED-CT via Orphanet
64Tumor Gene Family of Databases
65UMLS
66UMLS via Orphanet