DAZ
MCID: YCH001
MIFTS: 27

Y Chromosome Infertility (DAZ) malady

Genetic diseases, Rare diseases, Reproductive diseases categories
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Summaries for Y Chromosome Infertility

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NIH Rare Diseases:42 Y chromosome infertility is a condition that affects the production of sperm, making it difficult or impossible for affected men to father children. an affected man's body may produce no sperm cells (azoospermia), a smaller than usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly. this condition accounts for between 5 percent and 10 percent of cases of azoospermia or severe oligospermia. as its name suggests, this form of infertility is caused by changes in the y chromosome, one of the sex chromosomes. y chromosome infertility is usually caused by deletions of genetic material in regions of the y chromosome called azoospermia factor (azf) a, b, or c. genes in these regions are believed to provide instructions for making proteins involved in sperm cell development, although the specific functions of these proteins are not well understood. in rare cases, changes to a single gene called usp9y, which is located in the azfa region of the y chromosome, can cause y chromosome infertility. some men with y chromosome infertility who have mild to moderate oligospermia may eventually father a child naturally. assisted reproductive technologies may help other affected men. because y chromosome infertility impedes the ability to father children, this condition is usually caused by new deletions on the y chromosome and occurs in men with no history of the disorder in their family. when men with y chromosome infertility do father children, either naturally or with the aid of assisted reproductive technologies, they pass on the genetic changes on the y chromosome to all their sons. as a result, the sons will also have y chromosome infertility. last updated: 3/7/2013

MalaCards based summary: Y Chromosome Infertility, also known as y chromosome-related azoospermia, is related to oligospermia and infertility, and has symptoms including An important gene associated with Y Chromosome Infertility is USP9Y (ubiquitin specific peptidase 9, Y-linked). The compound Coenzyme A have been mentioned in the context of this disorder.

Genetics Home Reference:21 Y chromosome infertility is a condition that affects the production of sperm, making it difficult or impossible for affected men to father children. An affected man's body may produce no sperm cells (azoospermia), a smaller than usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly.

GeneReviews summary for yci

Aliases & Classifications for Y Chromosome Infertility

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Y Chromosome Infertility, Aliases & Descriptions:

Name: Y Chromosome Infertility 19 42 20 21 62
Y Chromosome-Related Azoospermia 19 21 62
Male Sterility Due to Y-Chromosome Deletions 42 62
Spermatogenic Failure, Y-Linked 21
Y Chromosome Microdeletions 42
 
Y-Chromosome Microdeletions 62
Gene Deletion Abnormality 62
Deleted in Azoospermia 42
Daz 42


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Genetic diseases, Rare diseases
Anatomical: Reproductive diseases


Related Diseases for Y Chromosome Infertility

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Graphical network of diseases related to Y Chromosome Infertility:



Diseases related to y chromosome infertility

Symptoms for Y Chromosome Infertility

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HPO human phenotypes related to Y Chromosome Infertility:

id Description Frequency HPO Source Accession
1 azoospermia HP:0000027
2 y-linked inheritance HP:0001450
3 abnormality of metabolism/homeostasis HP:0001939

Drugs & Therapeutics for Y Chromosome Infertility

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Drug clinical trials:

Search ClinicalTrials for Y Chromosome Infertility

Search NIH Clinical Center for Y Chromosome Infertility

Genetic Tests for Y Chromosome Infertility

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Genetic tests related to Y Chromosome Infertility:

id Genetic test Affiliating Genes
1 Y Chromosome Infertility20 USP9Y

Anatomical Context for Y Chromosome Infertility

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Animal Models for Y Chromosome Infertility or affiliated genes

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Publications for Y Chromosome Infertility

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Articles related to Y Chromosome Infertility:

idTitleAuthorsYear
1
Y Chromosome Infertility (20301513)
1993

Variations for Y Chromosome Infertility

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Expression for genes affiliated with Y Chromosome Infertility

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Expression patterns in normal tissues for genes affiliated with Y Chromosome Infertility

Search GEO for disease gene expression data for Y Chromosome Infertility.

Pathways for genes affiliated with Y Chromosome Infertility

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Compounds for genes affiliated with Y Chromosome Infertility

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Compounds related to Y Chromosome Infertility according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1Coenzyme A24 1110.6CDY1, CDY2A

GO Terms for genes affiliated with Y Chromosome Infertility

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Biological processes related to Y Chromosome Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single fertilizationGO:0073389.9XKRY, DAZ2
2multicellular organismal developmentGO:0072759.5DAZ3, DAZ2, DAZ1
3spermatogenesisGO:0072839.2USP9Y, DAZ3, DAZ2, DAZ1
4cell differentiationGO:0301549.2DAZ1, DAZ2, DAZ3

Molecular functions related to Y Chromosome Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:0037239.2DAZ3, DAZ2, DAZ1, DDX3Y
2nucleotide bindingGO:0001668.5RBMY1A1, DAZ3, DAZ2, DAZ1

Products for genes affiliated with Y Chromosome Infertility

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  • Antibodies
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Sources for Y Chromosome Infertility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet