DAZ
MCID: YCH001
MIFTS: 25

Y Chromosome Infertility (DAZ) malady

Reproductive category

Summaries for Y Chromosome Infertility

Sources:
21Genetics Home Reference, 43NIH Rare Diseases, 19GeneReviews, 33MalaCards
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NIH Rare Diseases:43 Y chromosome infertility is a condition that affects the production of sperm, making it difficult or impossible for affected men to father children. an affected man's body may produce no sperm cells (azoospermia), a smaller than usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly. this condition accounts for between 5 percent and 10 percent of cases of azoospermia or severe oligospermia. as its name suggests, this form of infertility is caused by changes in the y chromosome, one of the sex chromosomes. y chromosome infertility is usually caused by deletions of genetic material in regions of the y chromosome called azoospermia factor (azf) a, b, or c. genes in these regions are believed to provide instructions for making proteins involved in sperm cell development, although the specific functions of these proteins are not well understood. in rare cases, changes to a single gene called usp9y, which is located in the azfa region of the y chromosome, can cause y chromosome infertility. some men with y chromosome infertility who have mild to moderate oligospermia may eventually father a child naturally. assisted reproductive technologies may help other affected men. because y chromosome infertility impedes the ability to father children, this condition is usually caused by new deletions on the y chromosome and occurs in men with no history of the disorder in their family. when men with y chromosome infertility do father children, either naturally or with the aid of assisted reproductive technologies, they pass on the genetic changes on the y chromosome to all their sons. as a result, the sons will also have y chromosome infertility. last updated: 3/7/2013

MalaCards: Y Chromosome Infertility, also known as y chromosome-related azoospermia, is related to azoospermia and infertility. An important gene associated with Y Chromosome Infertility is USP9Y (ubiquitin specific peptidase 9, Y-linked). Affiliated tissues include b cells.

Genetics Home Reference:21 Y chromosome infertility is a condition that affects the production of sperm, making it difficult or impossible for affected men to father children. An affected man's body may produce no sperm cells (azoospermia), a smaller than usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly.

GeneReviews summary for yci

Aliases & Classifications for Y Chromosome Infertility

Sources:
19GeneReviews, 43NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 61UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive


Aliases & Descriptions:

y chromosome infertility 19 43 20 21
y chromosome-related azoospermia 19 21
male sterility due to y-chromosome deletions 43
spermatogenic failure, y-linked 21
y chromosome microdeletions 43
gene deletion abnormality 61
y chromosome deletions 61
deleted in azoospermia 43
daz 43


Related Diseases for Y Chromosome Infertility

Sources:
17GeneCards, 18GeneDecks
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Diseases related to Y Chromosome Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 116)
idRelated DiseaseScoreTop Affiliating Genes
1azoospermia31.0USP9Y, RBMY1A1, DDX3Y, CDY1, DAZ1, DAZ2
2infertility30.2DAZ2, DAZ1, USP9Y
3sertoli cell-only syndrome30.2USP9Y, DDX3Y, DAZ1, DAZ2
4oligospermia30.2USP9Y, RBMY1A1, DDX3Y, DAZ1
5cryptorchidism29.9DAZ1
6smith magenis syndrome29.9DAZ1, RBMY1A1, USP9Y
7spermatogenic failure, y-linked, 110.5
8spermatogenic failure, y-linked, 210.5
9globozoospermia10.3
10cystic fibrosis10.2
11n syndrome10.2
12varicocele10.2
13partial deletion of y10.2
14spermatogenic failure10.1
15klinefelter's syndrome10.0
16hypospadias10.0
17turner syndrome10.0
18micro syndrome10.0
19star syndrome10.0
20williams-beuren syndrome10.0
21trichorhinophalangeal syndrome type ii10.0
22cri-du-chat syndrome10.0
231p36 deletion syndrome10.0
241q21.1 microdeletion10.0
259q22.3 microdeletion10.0
2615q24 microdeletion syndrome10.0
27kleefstra syndrome10.0
28mitochondrial dna deletion syndromes10.0
29phelan-mcdermid syndrome10.0
30chromosome 10p deletion10.0
31chromosome 11p deletion10.0
32chromosome 11q deletion10.0
33jacobsen syndrome10.0
34chromosome 12p deletion10.0
35chromosome 12q deletion10.0
36chromosome 13q deletion10.0
37chromosome 14q deletion10.0
38chromosome 15q deletion10.0
39chromosome 15q25.2 deletion10.0
40chromosome 16p deletion10.0
4116p11.2 deletion syndrome10.0
42chromosome 16p13.3 deletion syndrome10.0
43chromosome 16q deletion10.0
44chromosome 17p deletion10.0
45chromosome 17p13.1 deletion syndrome10.0
46chromosome 17q deletion10.0
47chromosome 19p deletion10.0
48chromosome 19q deletion10.0
49chromosome 1p deletion10.0
50chromosome 1q deletion10.0

Graphical network of the top 20 diseases related to Y Chromosome Infertility:



Diseases related to y chromosome infertility

Clinical Features for Y Chromosome Infertility

Drugs & Therapeutics for Y Chromosome Infertility

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Y Chromosome Infertility

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20GeneTests
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Genetic tests related to Y Chromosome Infertility:

id Genetic test Affiliating Genes
1 Y Chromosome Infertility20 USP9Y

Anatomical Context for Y Chromosome Infertility

Sources:
33MalaCards
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MalaCards organs/tissues related to Y Chromosome Infertility:

33
B cells

Animal Models for Y Chromosome Infertility or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Y Chromosome Infertility

Sources:
51PubMed
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Articles related to Y Chromosome Infertility:

idTitleAuthorsYear
1
Human chromosome deletions in Yq11, AZF candidate genes and male infertility: history and update. (9733430)
1998

Genetic Variations for Y Chromosome Infertility

Expression for genes affiliated with Y Chromosome Infertility

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Y Chromosome Infertility

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Pathways for genes affiliated with Y Chromosome Infertility

Compounds for genes affiliated with Y Chromosome Infertility

GO Terms for genes affiliated with Y Chromosome Infertility

Sources:
16Gene Ontology
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Biological processes related to Y Chromosome Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single fertilizationGO:00733810.0DAZ2, XKRY
2spermatogenesisGO:0072838.2KDM5D, DAZ2, DAZ3, DAZ1, USP9Y

Molecular functions related to Y Chromosome Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:0037239.3DAZ2, DAZ3, DAZ1, DDX3Y
2nucleotide bindingGO:0001668.6DAZ2, DAZ3, DAZ1, RBMY1A1

Products for genes affiliated with Y Chromosome Infertility

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Sources for Y Chromosome Infertility

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet