DAZ
MCID: YCH001
MIFTS: 25

Y Chromosome Infertility (DAZ) malady

Reproductive diseases category

Summaries for Y Chromosome Infertility

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21Genetics Home Reference, 42NIH Rare Diseases, 19GeneReviews, 32MalaCards
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NIH Rare Diseases:42 Y chromosome infertility is a condition that affects the production of sperm, making it difficult or impossible for affected men to father children. an affected man's body may produce no sperm cells (azoospermia), a smaller than usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly. this condition accounts for between 5 percent and 10 percent of cases of azoospermia or severe oligospermia. as its name suggests, this form of infertility is caused by changes in the y chromosome, one of the sex chromosomes. y chromosome infertility is usually caused by deletions of genetic material in regions of the y chromosome called azoospermia factor (azf) a, b, or c. genes in these regions are believed to provide instructions for making proteins involved in sperm cell development, although the specific functions of these proteins are not well understood. in rare cases, changes to a single gene called usp9y, which is located in the azfa region of the y chromosome, can cause y chromosome infertility. some men with y chromosome infertility who have mild to moderate oligospermia may eventually father a child naturally. assisted reproductive technologies may help other affected men. because y chromosome infertility impedes the ability to father children, this condition is usually caused by new deletions on the y chromosome and occurs in men with no history of the disorder in their family. when men with y chromosome infertility do father children, either naturally or with the aid of assisted reproductive technologies, they pass on the genetic changes on the y chromosome to all their sons. as a result, the sons will also have y chromosome infertility. last updated: 3/7/2013

MalaCards: Y Chromosome Infertility, also known as y chromosome-related azoospermia, is related to azoospermia and male infertility. An important gene associated with Y Chromosome Infertility is USP9Y (ubiquitin specific peptidase 9, Y-linked).

Genetics Home Reference:21 Y chromosome infertility is a condition that affects the production of sperm, making it difficult or impossible for affected men to father children. An affected man's body may produce no sperm cells (azoospermia), a smaller than usual number of sperm cells (oligospermia), or sperm cells that are abnormally shaped or that do not move properly.

GeneReviews summary for yci

Aliases & Classifications for Y Chromosome Infertility

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19GeneReviews, 42NIH Rare Diseases, 20GeneTests, 21Genetics Home Reference, 60UMLS
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases


Aliases & Descriptions:

y chromosome infertility 19 42 20 21
y chromosome-related azoospermia 19 21
male sterility due to y-chromosome deletions 42
spermatogenic failure, y-linked 21
y chromosome microdeletions 42
gene deletion abnormality 60
y chromosome deletions 60
deleted in azoospermia 42
daz 42


Related Diseases for Y Chromosome Infertility

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17GeneCards, 18GeneDecks
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Diseases related to Y Chromosome Infertility via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show top 50)    (show all 112)
idRelated DiseaseScoreTop Affiliating Genes
1azoospermia30.9USP9Y, RBMY1A1, DDX3Y, CDY1, DAZ1, DAZ2
2male infertility30.6USP9Y, RBMY1A1, DDX3Y, DAZ1
3infertility30.2DAZ2, DAZ1, USP9Y
4sertoli cell-only syndrome30.2USP9Y, DDX3Y, DAZ1, DAZ2
5oligospermia30.1USP9Y, RBMY1A1, DDX3Y, DAZ1
6cryptorchidism29.9DAZ1
7smith magenis syndrome29.9DAZ1, RBMY1A1, USP9Y
8spermatogenic failure, y-linked, 110.4
9spermatogenic failure, y-linked, 210.4
10gonadal dysgenesis10.3
11cystic fibrosis10.1
12varicocele10.1
13partial deletion of y10.1
14gonadoblastoma10.0CDY1
15williams-beuren syndrome10.0
16trichorhinophalangeal syndrome type ii10.0
17cri-du-chat syndrome10.0
181p36 deletion syndrome10.0
191q21.1 microdeletion10.0
209q22.3 microdeletion10.0
2115q24 microdeletion syndrome10.0
22kleefstra syndrome10.0
23mitochondrial dna deletion syndromes10.0
24phelan-mcdermid syndrome10.0
25chromosome 10p deletion10.0
26chromosome 11p deletion10.0
27chromosome 11q deletion10.0
28jacobsen syndrome10.0
29chromosome 12p deletion10.0
30chromosome 12q deletion10.0
31chromosome 13q deletion10.0
32chromosome 14q deletion10.0
33chromosome 15q deletion10.0
34chromosome 15q25.2 deletion10.0
35chromosome 16p deletion10.0
3616p11.2 deletion syndrome10.0
37chromosome 16p13.3 deletion syndrome10.0
38chromosome 16q deletion10.0
39chromosome 17p deletion10.0
40chromosome 17p13.1 deletion syndrome10.0
41chromosome 17q deletion10.0
42chromosome 19p deletion10.0
43chromosome 19q deletion10.0
44chromosome 1p deletion10.0
45chromosome 1q deletion10.0
46chromosome 1q41-q42 deletion syndrome10.0
47chromosome 20p deletion10.0
48chromosome 20q deletion10.0
49chromosome 21q deletion10.0
50chromosome 22q deletion10.0

Graphical network of the top 20 diseases related to Y Chromosome Infertility:



Diseases related to y chromosome infertility

Clinical Features for Y Chromosome Infertility

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Drugs & Therapeutics for Y Chromosome Infertility

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5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
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Genetic Tests for Y Chromosome Infertility

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20GeneTests
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Genetic tests related to Y Chromosome Infertility:

id Genetic test Affiliating Genes
1 Y Chromosome Infertility20 USP9Y

Anatomical Context for Y Chromosome Infertility

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Animal Models for Y Chromosome Infertility or affiliated genes

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Publications for Y Chromosome Infertility

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Genetic Variations for Y Chromosome Infertility

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Expression for genes affiliated with Y Chromosome Infertility

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1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Y Chromosome Infertility

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Pathways for genes affiliated with Y Chromosome Infertility

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Compounds for genes affiliated with Y Chromosome Infertility

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GO Terms for genes affiliated with Y Chromosome Infertility

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16Gene Ontology
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Biological processes related to Y Chromosome Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1single fertilizationGO:00733810.0DAZ2, XKRY
2spermatogenesisGO:0072838.2KDM5D, DAZ2, DAZ3, DAZ1, USP9Y

Molecular functions related to Y Chromosome Infertility according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1RNA bindingGO:0037239.3DAZ2, DAZ3, DAZ1, DDX3Y
2nucleotide bindingGO:0001668.6DAZ2, DAZ3, DAZ1, RBMY1A1

Products for genes affiliated with Y Chromosome Infertility

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Sources for Y Chromosome Infertility

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet