MCID: YWS001
MIFTS: 44

Yaws malady

Infectious category

Summaries for Yaws

Sources:
8Disease Ontology, 64Wikipedia, 33MalaCards
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Disease Ontology:8 A primary bacterial infectious disease that results in infection located in skin, located in joint or located in bone, has material basis in treponema pallidum subsp pertenue, which is transmitted by direct skin contact with an infected person. the infection has symptom skin lesions.

MalaCards: Yaws, also known as frambesia tropica, is related to syphilis and early yaws, and has symptoms including skin lesions An important gene associated with Yaws is AQP4 (aquaporin 4), and among its related pathways are Activation of cAMP-Dependent PKA and Calcium Regulation in the Cardiac Cell. The compound gtp have been mentioned in the context of this disorder. Affiliated tissues include skin, joint or and skin, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Wikipedia:64 Yaws (also frambesia tropica, thymosis, polypapilloma tropicum, pian or parangi, \"Bouba\",... more...

Aliases & Classifications for Yaws

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Aliases & Descriptions:

yaws 8 43 10 61
frambesia tropica 8 43
frambesia 8 43
treponema pertenue infection 43
endemic treponematoses 43
polypapilloma tropicum 8
frambosie 8
thymosis 8
bouba 8


External Ids:

Disease Ontology8 DOID:10371
ICD9CM27 102, 102.9
NCIt40 C41353
MeSH35 D015001
ICD1025 A66, A66.9

Related Diseases for Yaws

Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases in the Yaws family:

early yaws late yaws

Diseases related to Yaws via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 21)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis10.8
2early yaws10.7
3late yaws10.6
4treponema infection10.3
5bejel10.3
6pineoblastoma10.0POU5F1
7colorectal cancer10.0NF2
8adenocarcinoma10.0NF2, AQP4, CPZ
9gonorrhea10.0WARS, EXTL3
10urethritis10.0
11asymptomatic neurosyphilis10.0
12cutaneous leishmaniasis10.0
13amebiasis10.0
14yellow fever10.0
15primary syphilis10.0
16secondary syphilis10.0
17chickenpox10.0
18lymphogranuloma venereum10.0
19smallpox10.0
20trypanosomiasis10.0
21tuberculosis10.0

Graphical network of the top 20 diseases related to Yaws:



Diseases related to yaws

Clinical Features for Yaws

Sources:
8Disease Ontology
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Symptoms:

8
  • skin lesions

Drugs & Therapeutics for Yaws

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials
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Approved drugs:

Search CenterWatch for Yaws

Drug clinical trials:

Search ClinicalTrials for Yaws

Search NIH Clinical Center for Yaws

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Genetic Tests for Yaws

Anatomical Context for Yaws

Sources:
14FMA, 33MalaCards
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MalaCards organs/tissues related to Yaws:

33
Skin, Appendix

FMA organs/tissues related to Yaws:

14
Skin, Joint or

Animal Models for Yaws or affiliated genes

Sources:
37MGI, 28inGenious Targeting Laboratory
See all sources

Publications for Yaws

Sources:
51PubMed
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Articles related to Yaws:

(show top 50)    (show all 391)
idTitleAuthorsYear
1
Whole genome sequence of the Treponema Fribourg-Blanc: unspecified simian isolate is highly similar to the yaws subspecies. (23638193)
2013
2
Yaws eradication: facing old problems, raising new hopes. (23209846)
2012
3
Challenges in recognition and diagnosis of yaws in children in Papua New Guinea. (21734134)
2011
4
Resurgence of yaws in Tanna, Vanuatu: time for a new approach? (20305095)
2010
5
Efficacy of a targeted, oral penicillin-based yaws control program among children living in rural South America. (12746767)
2003
6
Yaws in the periurban settlements of Port Moresby, Papua New Guinea. (12968791)
2002
7
Yaws in Ecuador: impact of control measures on the disease in the Province of Esmeraldas. (8566969)
1995
8
The history of venereal disease and yaws (parangi) in Sri Lanka (Ceylon). (8001951)
1994
9
Case report 724. Yaws. (1604348)
1992
10
Seroepidemiological characterization of a syphilis epidemic in the Republic of the Marshall Islands, formerly a yaws endemic area. (1634324)
1992
11
Radiological and dermatological findings in two patients suffering from early yaws in Indonesia. (2391113)
1990
12
Disseminated early yaws: report of a child with a remarkable genital lesion mimicking venereal syphilis. (2343008)
1990
13
Yaws truly--a survey of patients indexed under 'yaws' and a review of the clinical and laboratory problems of diagnosis. (3519012)
1986
14
Future application of research tests to the diagnosis of yaws and other endemic treponematoses. (3576302)
1986
15
Yaws in Colombia. (4012172)
1985
16
Resurgent yaws and other skin diseases in the Western Province of the Solomon Islands. (2940770)
1985
17
Yaws in the Americas. (4012170)
1985
18
Surveillance and control of resurgent yaws in the African region. (4012162)
1985
19
Yaws in Barbados. (4013246)
1985
20
Yaws and yellow fever project--Ghana. (6801453)
1982
21
Treponemal depigmentation, with special reference to yaws. (1265542)
1976
22
Syphilis and yaws: diagnostic difficulties and case report. (4516945)
1973
23
A selective approach to yaws control. (4747785)
1973
24
Electron microscopy of phagocytosis in syphilis and yaws. (5083438)
1972
25
Epidemiological study of yaws. (5966941)
1966
26
Late yaws and "dupuytren's contracture". (13936017)
1963
27
Yaws control in Ceylon. (14485219)
1962
28
Differential diagnosis of yaws. (13830703)
1960
29
Twenty years of yaws treatment amongst aboriginals in South Orissa. (13631020)
1959
30
A case of early yaws. (13618655)
1959
31
Yaws control in Netherlands New Guinea. (13577155)
1958
32
A short history of yaws in Trinidad. (13507341)
1957
33
The transmission of yaws in nature. (13449960)
1957
34
The value of the Chediak VDRL test in yaws serology compared with the standard VDRL-slide test. (13384192)
1956
35
Serology in syphilis and yaws. (13307428)
1955
36
Yaws in the Western Solomon Islands. (14354782)
1955
37
The modern story of yaws. (14350006)
1955
38
Recurrence of experimental yaws (framboesial) infection in the Hamster. (14359787)
1954
39
Yaws in Brazil. (13042580)
1953
40
Consolidation phase of yaws control: Experiences in Africa. (20603964)
1953
41
Yaws control; an opportunity for promoting rural health-services. (13042586)
1953
42
Bismuth salicylate in the treatment of yaws. (14901449)
1951
43
Repository penicillin therapy of yaws in the Haitian peasant. (15412277)
1950
44
A 5 day peroral treatment of yaws with STB, a new trivalent arsenical. (18116845)
1949
45
Gaps in the knowledge of yaws. (15395880)
1949
46
Tropical yaws; some clinical and roentgenological observations. (20250272)
1947
47
HISTORICUS [pseud.] Yaws and syphilis. (20340341)
1947
48
Interim notes on the therapeutics of bismuth, antimony, zinc, iron, and copper arsanilate in the treatment of malignant disease, syphilis, yaws, leprosy, tuberculosis, whooping cough and some minor complaints in the African. (20278571)
1946
49
Case for Diagnosis. ? Tertiary Yaws. (19986330)
1928
50
Experimental Investigations on Framboesia Tropica (Yaws). (20474329)
1907

Genetic Variations for Yaws

Expression for genes affiliated with Yaws

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Yaws

Search GEO for disease gene expression data for Yaws.

Pathways for genes affiliated with Yaws

Sources:
52QIAGEN, 38NCBI BioSystems Database
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Pathways related to Yaws according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.5RGS5, RGS16, RGS4, RGS1
2
Hide members
8.5RGS16, RGS4, RGS1, RGS5
3
Hide members
8.5RGS16, RGS1, RGS4, RGS5

Compounds for genes affiliated with Yaws

Sources:
45Novoseek, 29IUPHAR
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Compounds related to Yaws according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gtp45 299.5RGS1, RGS4, RGS16, RGS5

GO Terms for genes affiliated with Yaws

Sources:
16Gene Ontology
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Cellular components related to Yaws according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.3AQP4, EDN1, NF2, POU5F1, RGS5, RGS16

Biological processes related to Yaws according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of G-protein coupled receptor protein signaling pathwayGO:0082778.9RGS5, RGS16, RGS4
2termination of G-protein coupled receptor signaling pathwayGO:0380328.4RGS16, RGS1, RGS4, RGS5
3positive regulation of GTPase activityGO:0435478.2RGS16, RGS4, RGS1, RGS5

Molecular functions related to Yaws according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calmodulin bindingGO:0055168.7RGS1, RGS4, RGS16, MYH4
2GTPase activator activityGO:0050968.2RGS1, RGS4, RGS16, RGS5

Products for genes affiliated with Yaws

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Yaws

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet