YAWS
MCID: YWS001
MIFTS: 42

Yaws (YAWS) malady

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Yaws

Aliases & Descriptions for Yaws:

Name: Yaws 12 50 42 14 69
Frambesia Tropica 12 50
Frambesia 12 50
Treponema Pertenue Infection 50
Polypapilloma Tropicum 12
Endemic Treponematoses 50
Frambosie 12
Thymosis 12
Bouba 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10371
ICD10 33 A66 A66.9
ICD9CM 35 102 102.9
MeSH 42 D015001
NCIt 47 C41353
UMLS 69 C0043388

Summaries for Yaws

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in skin, located in joint or located in bone, has material basis in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has symptom skin lesions.

MalaCards based summary : Yaws, also known as frambesia tropica, is related to syphilis and late yaws, and has symptoms including skin lesions An important gene associated with Yaws is EXTL3 (Exostosin Like Glycosyltransferase 3). The drugs Menthol and Nimodipine have been mentioned in the context of this disorder. Affiliated tissues include skin, bone and testes, and related phenotypes are Dynamic nuclei (hole, folded or small irregular) and Negative genetic interaction between PTEN-/- and PTEN+/+

Wikipedia : 71 Yaws is a tropical infection of the skin, bones and joints caused by the spirochete bacterium Treponema... more...

Related Diseases for Yaws

Graphical network of the top 20 diseases related to Yaws:



Diseases related to Yaws

Symptoms & Phenotypes for Yaws

Symptoms:

12
  • skin lesions

GenomeRNAi Phenotypes related to Yaws according to GeneCards Suite gene sharing:

26
id Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 9.26 CD40LG CPZ EXTL3 MYH9
2 Negative genetic interaction between PTEN-/- and PTEN+/+ GR00255-A-3 8.8 CPZ MYH9 TPR

Drugs & Therapeutics for Yaws

Drugs for Yaws (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 110)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4 2216-51-5 16666
2
Nimodipine Approved Phase 4 66085-59-4 4497
3
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
4
Azithromycin Approved Phase 4,Phase 3 83905-01-5 55185 53477736 447043
5
Potassium Citrate Approved, Vet_approved Phase 4
6
Ivermectin Approved, Vet_approved Phase 4 70288-86-7 6474909 46936176
7
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
8
Diphenhydramine Approved Phase 4 58-73-1, 147-24-0 3100
9
Histamine Approved, Investigational Phase 4 75614-87-8, 51-45-6 774
10
Promethazine Approved Phase 4 60-87-7 4927
11 Antihypertensive Agents Phase 4
12 calcium channel blockers Phase 4
13 Calcium, Dietary Phase 4
14 Vasodilator Agents Phase 4
15 Central Nervous System Stimulants Phase 4
16 Dopamine Agents Phase 4,Phase 3
17 Dopamine Uptake Inhibitors Phase 4
18 Lisdexamfetamine Dimesylate Phase 4
19 Neurotransmitter Agents Phase 4,Phase 3
20 Neurotransmitter Uptake Inhibitors Phase 4
21 Anti-Infective Agents Phase 4,Phase 3
22 Antiemetics Phase 4,Phase 3
23 Autonomic Agents Phase 4,Phase 3
24 Central Nervous System Depressants Phase 4,Phase 3
25 Gastrointestinal Agents Phase 4,Phase 3
26 Peripheral Nervous System Agents Phase 4,Phase 3
27 Anticoagulants Phase 4
28 Chelating Agents Phase 4
29 diuretics Phase 4
30 Expectorants Phase 4
31 Natriuretic Agents Phase 4
32 Respiratory System Agents Phase 4
33 Antiparasitic Agents Phase 4
34 Dermatologic Agents Phase 4,Phase 3
35 Anesthetics Phase 4
36 Anesthetics, Local Phase 4
37 Anti-Allergic Agents Phase 4
38 Antipruritics Phase 4
39 Histamine Antagonists Phase 4
40 Histamine H1 Antagonists Phase 4
41
Histamine Phosphate Phase 4 51-74-1 65513
42 Hypnotics and Sedatives Phase 4
43 Citrate Nutraceutical Phase 4
44
Citric Acid Nutraceutical, Vet_approved Phase 4 77-92-9 311
45
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
46
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
47
Glyburide Approved Phase 3 10238-21-8 3488
48
Metformin Approved Phase 3 657-24-9 14219 4091
49
Rosiglitazone Approved, Investigational Phase 3 122320-73-4 77999
50
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 4594 9579578

Interventional clinical trials:

(show all 29)
id Name Status NCT ID Phase
1 Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes Unknown status NCT01220622 Phase 4
2 Does Pharmacological Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adults Enhance Parenting Performance? Completed NCT01127607 Phase 4
3 A Study on the Effection of Potassium Citrate Extended-release Tablets on Urolithiasis Formation or Recurrence Recruiting NCT03007160 Phase 4
4 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Active, not recruiting NCT02775617 Phase 4
5 Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Suspended NCT02136420 Phase 4
6 Comparison of Two Different Doses of Azithromycin for Treatment of Yaws Completed NCT02344628 Phase 3
7 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3
8 Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide Completed NCT00279045 Phase 3
9 Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs Completed NCT00241540 Phase 3
10 Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs Completed NCT00241514 Phase 3
11 Buccal Prochlorperazine Versus Intravenous Prochlorperazine for Migraine Headaches, a RCT Recruiting NCT02779959 Phase 3
12 Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma Recruiting NCT00876031 Phase 3
13 Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Active, not recruiting NCT01955252 Phase 3
14 The Role of Traditional Chinese Medicine in the Treatment of Chronic Childhood Immune Thrombocytopenia (ITP) Terminated NCT01226524 Phase 2, Phase 3
15 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
16 Entospletinib in Adults With Relapsed or Refractory Hematologic Malignancies Recruiting NCT01799889 Phase 2
17 Study on the Treatment of Bronchial Asthma With Traditional Chinese Medicine Not yet recruiting NCT02937207 Phase 2
18 Functioning Disturbance in Chronic Back Pain: Altered Muscle Metabolism Unknown status NCT01593839
19 Dual Point-of-care Test for the Diagnosis of Yaws Completed NCT01841203
20 Postural Effects of Being Rotated in a Whole Body Gyroscope Completed NCT01188161
21 Resistive/Cardiovascular Training Study Completed NCT00835601
22 The Effects of Dezocine Pretreatment on Dexamethasone Induced Perineal Irritation Completed NCT02768168
23 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
24 Transcutaneous Electrical Acupoint Stimulation for Non-small Cell Lung Cancer Patients Recruiting NCT02663492
25 RCT(Randomized Clinical Trial ) of Antibiotic Therapy in Chronic Endometritis Recruiting NCT02648698
26 Plasma Concentrations of Prophylactic Cefazolin in Pediatric Patients Undergoing Cardiac Surgery With CPB Recruiting NCT03141450
27 Percutaneous Transluminal Angioplasty Registry Recruiting NCT02728479
28 Study on Nation-wide Health Care Quality Information Openness and Transparency Mechanism Establishment No longer available NCT01194011
29 The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients Terminated NCT00164814

Search NIH Clinical Center for Yaws

Cochrane evidence based reviews: yaws

Genetic Tests for Yaws

Anatomical Context for Yaws

MalaCards organs/tissues related to Yaws:

39
Skin, Bone, Testes, Eye, Appendix

The Foundational Model of Anatomy Ontology organs/tissues related to Yaws:

18
Skin, Joint Or

Publications for Yaws

Articles related to Yaws:

(show top 50) (show all 438)
id Title Authors Year
1
Mathematical Modeling of Programmatic Requirements for Yaws Eradication. ( 27983500 )
2017
2
New Diagnostics for Yaws. ( 28077737 )
2017
3
A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. ( 28072863 )
2017
4
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626527 )
2016
5
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626525 )
2016
6
Meta-analysis of the performance of a combined treponemal and non-treponemal rapid diagnostic test for syphilis and yaws. ( 27217216 )
2016
7
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626526 )
2016
8
Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji. ( 27852877 )
2016
9
Flies and Yaws: Molecular Studies Provide New Insight. ( 27568221 )
2016
10
Evaluation of Multiplex-Based Antibody Testing for Use in Large-Scale Surveillance for Yaws: a Comparative Study. ( 26962086 )
2016
11
Yaws: towards the WHO eradication target. ( 27268712 )
2016
12
Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana. ( 27531187 )
2016
13
Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma. ( 27551787 )
2016
14
WHO Declares India Free of Yaws and Maternal and Neonatal Tetanus. ( 27654592 )
2016
15
Eradicating successfully yaws from India: The strategy & global lessons. ( 26139778 )
2015
16
Trachoma and Yaws: Common Ground? ( 26633176 )
2015
17
Yaws: 110 Years After Castellani's Discovery of Treponema pallidum Subspecies pertenue. ( 25870417 )
2015
18
Mass treatment with single-dose azithromycin for yaws. ( 25693010 )
2015
19
Global epidemiology of yaws: a systematic review. ( 26001576 )
2015
20
Yaws. ( 25525120 )
2015
21
A cross-sectional study of 'yaws' in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control. ( 25632942 )
2015
22
Challenges and key research questions for yaws eradication. ( 26362174 )
2015
23
Yaws eradication--a goal finally within reach. ( 25693007 )
2015
24
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. ( 26241484 )
2015
25
Mapping the geographical distribution of yaws. ( 26001570 )
2015
26
Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains? ( 26217043 )
2015
27
Tropical leg ulcers in children: more than yaws. ( 26289420 )
2015
28
Mapping the epidemiology of yaws in the Solomon Islands: a cluster randomized survey. ( 25422395 )
2015
29
Eradication of yaws in India. ( 25902561 )
2015
30
Failure of PCR to Detect Treponema pallidum ssp. pertenue DNA in Blood in Latent Yaws. ( 26125585 )
2015
31
Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study. ( 25103064 )
2014
32
Neglected tropical diseases. Oral antibiotic raises hopes of eradicating yaws. ( 24723591 )
2014
33
Sensitivity and specificity of a rapid point-of-care test for active yaws: a comparative study. ( 25103395 )
2014
34
The molecular typing data of recently identified subtype 11q/j of Treponema pallidum subsp. pallidum suggest imported case of yaws. ( 25118969 )
2014
35
Yaws: renewed hope for eradication. ( 25103223 )
2014
36
Endemic yaws in early 20th century Kerala. ( 25327037 )
2014
37
Epidemiology of yaws: an update. ( 24729728 )
2014
38
Evaluation of a rapid diagnostic test for yaws infection in a community surveillance setting. ( 25211018 )
2014
39
Progress in treatment and diagnosis of yaws: hope for eradication? ( 25103375 )
2014
40
Yaws. ( 25193248 )
2014
41
Molecular Differentiation of Treponema pallidum Subspecies in Skin Ulceration Clinically Suspected as Yaws in Vanuatu Using Real-Time Multiplex PCR and Serological Methods. ( 25404075 )
2014
42
Whole Genome Sequence of the Treponema pallidum subsp. endemicum Strain Bosnia A: The Genome Is Related to Yaws Treponemes but Contains Few Loci Similar to Syphilis Treponemes. ( 25375929 )
2014
43
Yaws, syphilis, sexuality, and the circulation of medical knowledge in the British Caribbean and the Atlantic world. ( 24976161 )
2014
44
Where the road ends, yaws begins? The cost-effectiveness of eradication versus more roads. ( 25255131 )
2014
45
Eradication of yaws: historical efforts and achieving WHO's 2020 target. ( 25254372 )
2014
46
Serologic cross-reactivity of syphilis, yaws, and pinta. ( 23317070 )
2013
47
Whole genome sequence of the Treponema Fribourg-Blanc: unspecified simian isolate is highly similar to the yaws subspecies. ( 23638193 )
2013
48
Practising in PNG: pidgin, rugby and yaws. ( 24329671 )
2013
49
Developments in therapy and diagnosis of yaws and future prospects. ( 24073783 )
2013
50
Yaws. ( 23415015 )
2013

Variations for Yaws

Expression for Yaws

Search GEO for disease gene expression data for Yaws.

Pathways for Yaws

GO Terms for Yaws

Cellular components related to Yaws according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 spindle GO:0005819 8.62 MYH9 TPR

Molecular functions related to Yaws according to GeneCards Suite gene sharing:

id Name GO ID Score Top Affiliating Genes
1 protein anchor GO:0043495 8.62 MYH9 TPR

Sources for Yaws

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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