YAWS
MCID: YWS001
MIFTS: 48

Yaws (YAWS) malady

Infectious diseases category

Summaries for Yaws

About this section
Sources:
8Disease Ontology, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
Disease Ontology:8 A primary bacterial infectious disease that results in infection located in skin, located in joint or located in bone, has material basis in treponema pallidum subsp pertenue, which is transmitted by direct skin contact with an infected person. the infection has symptom skin lesions.

MalaCards: Yaws, also known as frambesia tropica, is related to syphilis and early yaws, and has symptoms including skin lesions An important gene associated with Yaws is AQP4 (aquaporin 4), and among its related pathways are Calcium Regulation in the Cardiac Cell and Activation of cAMP-Dependent PKA. The compound gtp have been mentioned in the context of this disorder. Affiliated tissues include skin, joint or and skin, and related mouse phenotypes are endocrine/exocrine gland and immune system.

Wikipedia:63 Yaws (also known as frambesia tropica, thymosis, polypapilloma tropicum, parangi, bouba, frambösie, and... more...

Aliases & Classifications for Yaws

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Aliases & Descriptions:

yaws 8 42 10 60
frambesia tropica 8 42
frambesia 8 42
treponema pertenue infection 42
endemic treponematoses 42
polypapilloma tropicum 8
frambosie 8
thymosis 8
bouba 8


External Ids:

Disease Ontology8 DOID:10371
ICD9CM27 102, 102.9
NCIt39 C41353
MeSH34 D015001
ICD1025 A66, A66.9

Related Diseases for Yaws

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Diseases related to Yaws via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

(show all 28)
idRelated DiseaseScoreTop Affiliating Genes
1syphilis10.8
2early yaws10.7
3late yaws10.6
4bejel10.2
5leishmaniasis10.2
6leprosy10.1
7motion sickness10.1
8pneumonia10.1
9skin disease10.1
10pineoblastoma10.0POU5F1
11colorectal cancer10.0NF2
12adenocarcinoma10.0NF2, AQP4, CPZ
13gonorrhea10.0WARS, EXTL3
14urethritis9.9
15asymptomatic neurosyphilis9.9
16cutaneous leishmaniasis9.9
17amebiasis9.9
18yellow fever9.9
19primary syphilis9.9
20secondary syphilis9.9
21chickenpox9.9
22lymphogranuloma venereum9.9
23optic atrophy9.9
24papilloma9.9
25smallpox9.9
26trypanosomiasis9.9
27tuberculosis9.9
28treponema infection9.9

Graphical network of the top 20 diseases related to Yaws:



Diseases related to yaws

Clinical Features for Yaws

About this section
Sources:
8Disease Ontology
See all sources


Symptoms:

8
  • skin lesions

Drugs & Therapeutics for Yaws

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials
See all sources

Approved drugs:

Search CenterWatch for Yaws

Drug clinical trials:

Search ClinicalTrials for Yaws

Search NIH Clinical Center for Yaws

Search CenterWatch for Yaws

Genetic Tests for Yaws

About this section

Anatomical Context for Yaws

About this section
Sources:
32MalaCards, 14FMA
See all sources

MalaCards organs/tissues related to Yaws:

32
Skin, Bone, Testes, Eye, Appendix

FMA organs/tissues related to Yaws:

14
Skin, Joint or

Animal Models for Yaws or affiliated genes

About this section
Sources:
36MGI
See all sources

MGI Mouse Phenotypes related to Yaws:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053798.4NF2, EDN1, POU5F1, RGS4, AQP4, EXTL3
2MP:00053878.1NF2, MYH4, RGS5, RGS16, RGS1, SETDB1
3MP:00053767.0RGS16, RGS5, NF2, EDN1, AQP4, PPM1A

Publications for Yaws

About this section
Sources:
50PubMed
See all sources

Articles related to Yaws:

(show top 50)    (show all 393)
idTitleAuthorsYear
1
Yaws. (23415015)
2013
2
Advances in the diagnosis of endemic treponematoses: yaws, bejel, and pinta. (24205410)
2013
3
Update on a neglected tropical disease from the routine health information system in CA'te d'Ivoire: Yaws, 2001 to 2011. (24334405)
2013
4
Oral azithromycin for treatment of yaws. (22240406)
2012
5
Whole genome sequence of Treponema pallidum ssp. pallidum, strain Mexico A, suggests recombination between yaws and syphilis strains. (23029591)
2012
6
Axis rotation and visually induced motion sickness: the role of combined roll, pitch, and yaw motion. (22097636)
2011
7
Secondary yaws: an endemic treponemal infection. (20653853)
2010
8
Goundou: a historical form of yaws. (12387970)
2002
9
Yaws and syphilis in the Garkida area of Nigeria. (10096171)
1999
10
The localisation of treponemes and characterisation of the inflammatory infiltrate in skin biopsies from patients with primary or secondary syphilis, or early infectious yaws. (8509088)
1993
11
The resurgence of yaws. World-wide consequences. (2001914)
1991
12
Leg ulcers caused by yaws and endemic syphilis. (2129945)
1990
13
Nasal manifestations of yaws. (3225527)
1988
14
An investigation of yaws on the Trobriand Islands, 1985. (3475870)
1987
15
Occurrence of congenital, cardiovascular, visceral, neurologic, and neuro-ophthalmologic complications in late yaws: a theme for future research. (3538316)
1986
16
Situation of control of yaws in the Southeast Asia region: past, present, and future. (3576295)
1986
17
Yaws. (3792046)
1986
18
Yaws in Ghana. (4012163)
1985
19
Yaws in Barbados. (4013246)
1985
20
On the epidemiology of yaws in African miners (1942). (6485057)
1984
21
Late yaws: a case report. (6927784)
1982
22
Yaws in India--it status in 1981. (6982913)
1982
23
Case for diagnosis. Disseminated (early) yaws. (6798505)
1981
24
Yaws again. (7427596)
1980
25
On PAHO yaws control program. (655326)
1978
26
Goundou--tertiary yaws in the maxilla. (1059484)
1975
27
TPHA and RPL tests for yaws antibodies. (4609564)
1974
28
Yaws. (4931651)
1971
29
Yaws eradication in Indonesia: Dr. Raden Kodijat's contribution. (4922134)
1970
30
Yaws survey--Jamaica, 1963. (5828918)
1965
31
DERMAL LEISHMANIASIS (BUSH YAWS) IN BRITISH GUIANA. (14259518)
1964
32
AN EPIDEMIOLOGICAL STUDY OF YAWS IN MADHYA PRADESH--ECONOMIC ASPECT. (14073635)
1963
33
Control of endemic yaws in the Brong Ahafo region of Ghana. (13974810)
1963
34
Some epidemiological aspects of yaws eradication. (13710280)
1960
35
Yaws Osteoperiostitis of Fibula. (19994004)
1959
36
Yaws in Brazil. (13536799)
1958
37
Bone yaws; report on a case. (13635855)
1958
38
Plantar hyperkeratosis ? yaws. (13560719)
1958
39
An international nomenclature of yaws lesions. (13519779)
1957
40
Endemic syphilis and yaws. (13404469)
1956
41
Yaws in the western Solomon Islands; second resurvey of the island of Simbo in March 1955. (14392682)
1955
42
Consolidation phase of yaws control; experiences in Africa. (13042584)
1953
43
Yaws and flies; past and present opinions on the rA'le of flies in the transmission of framboesia tropica. (14939338)
1952
44
Electronmicrography of treponemas from cases of yaws, pinta, and the so-called Cuban form of pinta. (14857252)
1951
45
Phase contrast microscopy for demonstration of Treponema pertenue in yaws lesions. (14799712)
1951
46
Yaws treated with single massive doses of penicillin. (20272961)
1947
47
The clinical course of yaws in Lango, Uganda. (20286125)
1946
48
A yaws clinic in New Georgia. (20995039)
1946
49
YAWS. (21772572)
1928
50
YAWS in the SOUTH SEA ISLANDS. (20757906)
1898

Genetic Variations for Yaws

About this section

Expression for genes affiliated with Yaws

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Yaws

Search GEO for disease gene expression data for Yaws.

Pathways for genes affiliated with Yaws

About this section
Sources:
37NCBI BioSystems Database, 51QIAGEN
See all sources

Pathways related to Yaws according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Hide members
8.5RGS5, RGS16, RGS4, RGS1
2
Hide members
8.5RGS1, RGS4, RGS16, RGS5
3
Hide members
8.5RGS1, RGS4, RGS16, RGS5

Compounds for genes affiliated with Yaws

About this section
Sources:
44Novoseek, 28IUPHAR
See all sources

Compounds related to Yaws according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1gtp44 289.5RGS1, RGS4, RGS16, RGS5

GO Terms for genes affiliated with Yaws

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Yaws according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1cytoplasmGO:0057376.3AQP4, EDN1, NF2, POU5F1, RGS5, RGS16

Biological processes related to Yaws according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1regulation of G-protein coupled receptor protein signaling pathwayGO:0082778.9RGS5, RGS16, RGS4
2termination of G-protein coupled receptor signaling pathwayGO:0380328.4RGS16, RGS1, RGS4, RGS5
3positive regulation of GTPase activityGO:0435478.2RGS16, RGS4, RGS1, RGS5

Molecular functions related to Yaws according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1calmodulin bindingGO:0055168.7RGS1, RGS4, RGS16, MYH4
2GTPase activator activityGO:0050968.2RGS1, RGS4, RGS16, RGS5

Products for genes affiliated with Yaws

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Yaws

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet