Aliases & Classifications for Yaws

MalaCards integrated aliases for Yaws:

Name: Yaws 12 72 49 41 14 69
Frambesia Tropica 12 49
Frambesia 12 49
Treponema Pertenue Infection 49
Polypapilloma Tropicum 12
Endemic Treponematoses 49
Frambosie 12
Thymosis 12
Bouba 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10371
ICD10 32 A66 A66.9
ICD9CM 34 102 102.9
MeSH 41 D015001
NCIt 46 C41353
UMLS 69 C0043388

Summaries for Yaws

Disease Ontology : 12 A primary bacterial infectious disease that results_in infection located in skin, located in joint or located in bone, has material basis in Treponema pallidum subsp pertenue, which is transmitted_by direct skin contact with an infected person. The infection has symptom skin lesions.

MalaCards based summary : Yaws, also known as frambesia tropica, is related to syphilis and secondary syphilis, and has symptoms including skin lesions An important gene associated with Yaws is EXTL3 (Exostosin Like Glycosyltransferase 3). The drugs Menthol and Nimodipine have been mentioned in the context of this disorder. Affiliated tissues include skin, joint or and skin.

Wikipedia : 72 Yaws is a tropical infection of the skin, bones and joints caused by the spirochete bacterium Treponema... more...

Related Diseases for Yaws

Graphical network of the top 20 diseases related to Yaws:



Diseases related to Yaws

Symptoms & Phenotypes for Yaws

Symptoms:

12
  • skin lesions

Drugs & Therapeutics for Yaws

Drugs for Yaws (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Menthol Approved Phase 4 2216-51-5 16666
2
Nimodipine Approved, Investigational Phase 4 66085-59-4 4497
3
Dopamine Approved Phase 4,Phase 3 51-61-6, 62-31-7 681
4
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
5
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
6
Promethazine Approved, Investigational Phase 4 60-87-7 4927
7
Azithromycin Approved Phase 4,Phase 3 83905-01-5 53477736 447043 55185
8
Potassium Citrate Approved, Investigational, Vet_approved Phase 4
9
Ivermectin Approved, Investigational, Vet_approved Phase 4 70288-86-7 46936176 6474909
10
Permethrin Approved, Investigational Phase 4 52645-53-1 40326
11
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
12 Antihypertensive Agents Phase 4
13 calcium channel blockers Phase 4
14 Calcium, Dietary Phase 4
15 Vasodilator Agents Phase 4
16 Central Nervous System Stimulants Phase 4
17 Dopamine Agents Phase 4,Phase 3
18 Dopamine Uptake Inhibitors Phase 4
19 Lisdexamfetamine Dimesylate Phase 4
20 Neurotransmitter Agents Phase 4,Phase 3
21 Neurotransmitter Uptake Inhibitors Phase 4
22 Anesthetics Phase 4
23 Anesthetics, Local Phase 4
24 Anti-Allergic Agents Phase 4
25 Antiemetics Phase 4,Phase 3
26 Antipruritics Phase 4
27 Autonomic Agents Phase 4,Phase 3
28 Central Nervous System Depressants Phase 4,Phase 3
29 Dermatologic Agents Phase 4,Phase 3
30 Gastrointestinal Agents Phase 4,Phase 3
31 Histamine Antagonists Phase 4
32 Histamine H1 Antagonists Phase 4
33
Histamine Phosphate Phase 4 51-74-1 65513
34 Hypnotics and Sedatives Phase 4
35 Peripheral Nervous System Agents Phase 4,Phase 3
36 Anti-Infective Agents Phase 4,Phase 3
37 Anticoagulants Phase 4
38 Chelating Agents Phase 4
39 diuretics Phase 4
40 Expectorants Phase 4
41 Natriuretic Agents Phase 4
42 Respiratory System Agents Phase 4
43 Antiparasitic Agents Phase 4
44 Citrate Nutraceutical Phase 4
45
Penicillin G Approved, Vet_approved Phase 3 61-33-6 5904
46
Procaine Approved, Investigational, Vet_approved Phase 3 59-46-1 4914
47
Glyburide Approved Phase 3 10238-21-8 3488
48
Metformin Approved Phase 3 657-24-9 4091 14219
49
Rosiglitazone Approved, Investigational Phase 3 122320-73-4 77999
50
Esomeprazole Approved, Investigational Phase 3 161796-78-7, 119141-88-7 9579578 4594

Interventional clinical trials:

(show all 31)

# Name Status NCT ID Phase Drugs
1 Efficacy and Safety Study of Nimodipine to Prevent Mild Cognitive Impairment After Acute Ischemic Strokes Unknown status NCT01220622 Phase 4 Nimodipine;Placebo
2 Does Pharmacological Treatment of Attention Deficit Hyperactivity Disorder (ADHD) in Adults Enhance Parenting Performance? Completed NCT01127607 Phase 4 lisdexamfetamine
3 Countermeasures to Reduce Sensorimotor Impairment and Space Motion Sickness Resulting From Altered Gravity Levels Completed NCT02136420 Phase 4 Promethazine;Placebo
4 A Study on the Effection of Potassium Citrate Extended-release Tablets on Urolithiasis Formation or Recurrence Recruiting NCT03007160 Phase 4 Potassium Citrate Extended-release Tablets
5 Azithromycin - Ivermectin Mass Drug Administration for Skin Disease Active, not recruiting NCT02775617 Phase 4 Ivermectin;Azithromycin;Permethrin
6 Effect of WHO-yaws Elimination Strategy in Lihir Island, Papua New Guinea Completed NCT01955252 Phase 3 Azithromycin
7 Comparison of Two Different Doses of Azithromycin for Treatment of Yaws Completed NCT02344628 Phase 3 Azithromycin
8 Single-dose Azithromycin for the Treatment of Yaws Completed NCT01382004 Phase 3 Penicillin-G-benzathine;Azithromycin
9 Diabetes Study With Rosiglitazone Monotherapy Versus Metformin Or Glyburide/Glibenclamide Completed NCT00279045 Phase 3 Rosiglitazone;glyburide;metformin
10 Esomeprazole for Relief of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs Completed NCT00241540 Phase 3 Esomeprazole
11 Esomeprazole for Prevention of Upper Gastrointestinal Symptoms Associated With Continuous Use of NSAIDs Completed NCT00241514 Phase 3 Esomeprazole
12 Trial for Localised High-risk Rhabdomyosarcoma and Rhabdomyosarcoma-like Soft Tissue Sarcoma Recruiting NCT00876031 Phase 3 trofosfamide, idarubicin, etoposide
13 Buccal Prochlorperazine Versus Intravenous Prochlorperazine for Migraine Headaches, a RCT Active, not recruiting NCT02779959 Phase 3 Prochlorperazine
14 The Phase III Study of Icaritin Versus HUACHANSU PIAN in Hepatocellular Carcinoma Subjects Not yet recruiting NCT03236636 Phase 3 Icaritin;HUACHANSU PIAN
15 The Role of Traditional Chinese Medicine in the Treatment of Chronic Childhood Immune Thrombocytopenia (ITP) Terminated NCT01226524 Phase 2, Phase 3 Bu Zhong Yi Qi Tang, Zhi Xue Tang, Chuan xin lian kang yan pian mod, Tian Wang Bu xin Dan
16 Treatments for Benign Paroxysmal Positional Vertigo (BPPV) Completed NCT00000359 Phase 2
17 Study on the Treatment of Bronchial Asthma With Traditional Chinese Medicine Not yet recruiting NCT02937207 Phase 2 Ke Chuan Liu Wei Mixture;Chuan Xiong Ping Chuan Mixture;Xie Wu Capsule;Dan Ma Jia Tablet;Zhi Chuan Capsule;Bu Shen Na Qi Granule;Ke Chuan Liu Wei Mixture placebo;Chuan Xiong Ping Chuan Mixture placebo;Xie Wu Capsule placebo;Dan Ma Jia Tablet placebo;Zhi Chuan Capsule placebo;Bu Shen Na Qi Granule placebo
18 Transcutaneous Electrical Acupoint Stimulation for Non-small Cell Lung Cancer Patients Unknown status NCT02663492 Sanguisorba officinalis L.
19 Functioning Disturbance in Chronic Back Pain: Altered Muscle Metabolism Unknown status NCT01593839
20 Dual Point-of-care Test for the Diagnosis of Yaws Completed NCT01841203
21 Postural Effects of Being Rotated in a Whole Body Gyroscope Completed NCT01188161
22 Resistive/Cardiovascular Training Study Completed NCT00835601
23 The Effects of Dezocine Pretreatment on Dexamethasone Induced Perineal Irritation Completed NCT02768168 dezocine
24 Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France Completed NCT01211652
25 RCT(Randomized Clinical Trial ) of Antibiotic Therapy in Chronic Endometritis Recruiting NCT02648698 antibiotics;placebo
26 The Smart Hypertension Control Study Recruiting NCT03288142
27 Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering Recruiting NCT03375216
28 Plasma Concentrations of Prophylactic Cefazolin in Pediatric Patients Undergoing Cardiac Surgery With CPB Recruiting NCT03141450
29 Percutaneous Transluminal Angioplasty Registry Recruiting NCT02728479
30 Study on Nation-wide Health Care Quality Information Openness and Transparency Mechanism Establishment No longer available NCT01194011
31 The Role of Visceral Hyperalgesia, Gastroesophageal Reflux Disease (GERD) and Esophageal Motility Disorder (EMD) in NCCP Patients Terminated NCT00164814

Search NIH Clinical Center for Yaws

Cochrane evidence based reviews: yaws

Genetic Tests for Yaws

Anatomical Context for Yaws

The Foundational Model of Anatomy Ontology organs/tissues related to Yaws:

18
Skin, Joint Or

MalaCards organs/tissues related to Yaws:

38
Skin, Bone, Testes, Lung, Eye, Appendix

Publications for Yaws

Articles related to Yaws:

(show top 50) (show all 452)
# Title Authors Year
1
Macrolide resistance in yaws. ( 29428184 )
2018
2
Re-emergence of yaws after single mass azithromycin treatment followed by targeted treatment: a longitudinal study. ( 29428183 )
2018
3
Mathematical Modeling of Programmatic Requirements for Yaws Eradication. ( 27983500 )
2017
4
Bone lesions in yaws - another potential marker of indigenous Australian remains. ( 28695420 )
2017
5
Development of a Multilocus Sequence Typing (MLST) scheme for Treponema pallidum subsp. pertenue: Application to yaws in Lihir Island, Papua New Guinea. ( 29281641 )
2017
6
Targeted Treatment of Yaws With Household Contact Tracing: How Much do we Miss? ( 29140407 )
2017
7
Single-dose azithromycin to treat latent yaws. ( 29107622 )
2017
8
Knowledge, attitudes and practices towards yaws and yaws-like skin disease in Ghana. ( 28759580 )
2017
9
Yaws Osteoperiostitis Treated with Single-Dose Azithromycin. ( 28193743 )
2017
10
Diagnostics for yaws eradication: insights from direct next generation sequencing of cutaneous strains of Treponema pallidum. ( 29045605 )
2017
11
Vection is the main contributor to motion sickness induced by visual yaw rotation: Implications for conflict and eye movement theories. ( 28380077 )
2017
12
Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study. ( 29107621 )
2017
13
Yaws resurgence in Bankim, Cameroon: The relative effectiveness of different means of detection in rural communities. ( 28481900 )
2017
14
New Diagnostics for Yaws. ( 28077737 )
2017
15
A Single Dose Oral Azithromycin versus Intramuscular Benzathine Penicillin for the Treatment of Yaws-A Randomized Non Inferiority Trial in Ghana. ( 28072863 )
2017
16
The cost and cost-effectiveness of rapid testing strategies for yaws diagnosis and surveillance. ( 29073145 )
2017
17
Integrated Mapping of Yaws and Trachoma in the Five Northern-Most Provinces of Vanuatu. ( 28118354 )
2017
18
Yaws: towards the WHO eradication target. ( 27268712 )
2016
19
Prevalence of Active and Latent Yaws in the Solomon Islands 18 Months after Azithromycin Mass Drug Administration for Trachoma. ( 27551787 )
2016
20
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626527 )
2016
21
Meta-analysis of the performance of a combined treponemal and non-treponemal rapid diagnostic test for syphilis and yaws. ( 27217216 )
2016
22
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626525 )
2016
23
Mass Treatment with Single-Dose Azithromycin for Yaws. ( 27626526 )
2016
24
Evaluation of Multiplex-Based Antibody Testing for Use in Large-Scale Surveillance for Yaws: a Comparative Study. ( 26962086 )
2016
25
WHO Declares India Free of Yaws and Maternal and Neonatal Tetanus. ( 27654592 )
2016
26
Recall of symptoms and treatment of syphilis and yaws by healthy blood donors screening positive for syphilis in Kumasi, Ghana. ( 27531187 )
2016
27
Flies and Yaws: Molecular Studies Provide New Insight. ( 27568221 )
2016
28
Community seroprevalence survey for yaws and trachoma in the Western Division of Fiji. ( 27852877 )
2016
29
A cross-sectional study of 'yaws' in districts of Ghana which have previously undertaken azithromycin mass drug administration for trachoma control. ( 25632942 )
2015
30
Yaws. ( 25525120 )
2015
31
Trachoma and Yaws: Common Ground? ( 26633176 )
2015
32
Yaws eradication--a goal finally within reach. ( 25693007 )
2015
33
Eradicating successfully yaws from India: The strategy & global lessons. ( 26139778 )
2015
34
Mapping the geographical distribution of yaws. ( 26001570 )
2015
35
Failure of PCR to Detect Treponema pallidum ssp. pertenue DNA in Blood in Latent Yaws. ( 26125585 )
2015
36
Global epidemiology of yaws: a systematic review. ( 26001576 )
2015
37
Mass treatment with single-dose azithromycin for yaws. ( 25693010 )
2015
38
Challenges and key research questions for yaws eradication. ( 26362174 )
2015
39
Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws. ( 26241484 )
2015
40
Macrolide Resistance in the Syphilis Spirochete, Treponema pallidum ssp. pallidum: Can We Also Expect Macrolide-Resistant Yaws Strains? ( 26217043 )
2015
41
Mapping the epidemiology of yaws in the Solomon Islands: a cluster randomized survey. ( 25422395 )
2015
42
Eradication of yaws in India. ( 25902561 )
2015
43
Tropical leg ulcers in children: more than yaws. ( 26289420 )
2015
44
Yaws: 110 Years After Castellani's Discovery of Treponema pallidum Subspecies pertenue. ( 25870417 )
2015
45
Eradication of yaws: historical efforts and achieving WHO's 2020 target. ( 25254372 )
2014
46
Sensitivity and specificity of a rapid point-of-care test for active yaws: a comparative study. ( 25103395 )
2014
47
The molecular typing data of recently identified subtype 11q/j of Treponema pallidum subsp. pallidum suggest imported case of yaws. ( 25118969 )
2014
48
Endemic yaws in early 20th century Kerala. ( 25327037 )
2014
49
Haemophilus ducreyi as a cause of skin ulcers in children from a yaws-endemic area of Papua New Guinea: a prospective cohort study. ( 25103064 )
2014
50
Yaws: renewed hope for eradication. ( 25103223 )
2014

Variations for Yaws

Expression for Yaws

Search GEO for disease gene expression data for Yaws.

Pathways for Yaws

GO Terms for Yaws

Sources for Yaws

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
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50 NINDS
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65 SNOMED-CT via HPO
66 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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