YF
MCID: YLL002
MIFTS: 57

Yellow Fever (YF) malady

Infectious diseases category

Summaries for Yellow Fever

About this section
Sources:
8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
See all sources

Fully expand this MalaCard

Export this MalaCard
CDC:3 Yellow fever virus is found in tropical and subtropical areas in South America and Africa. The virus is transmitted to humans by the bite of an infected mosquito. Yellow fever is a very rare cause of illness in U.S. travelers. Illness ranges in severity from a self-limited febrile illness to severe liver disease with bleeding. Yellow fever disease is diagnosed based on symptoms, physical findings, laboratory testing, and travel history, including the possibility of exposure to infected mosquitoes. There is no specific treatment for yellow fever; care is based on symptoms. Steps to prevent yellow fever virus infection include using insect repellent, wearing protective clothing, and getting vaccinated.

MalaCards: Yellow Fever, also known as jungle yellow fever, is related to encephalitis and atopic dermatitis, and has symptoms including spontaneous abortions, fever and headache. An important gene associated with Yellow Fever is SCP2 (sterol carrier protein 2), and among its related pathways are TNF signaling pathway and Chemokine receptors bind chemokines. The compounds poly(i-c) and groalpha have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and skin.

Disease Ontology:8 A viral infectious disease that results in infection, has material basis in yellow fever virus, which is transmitted by aedes, transmitted by haemagogus, or transmitted by sabethes species of mosquitoes. the infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

Wikipedia:63 Yellow fever, known historically as yellow jack, or yellow plague is an acute viral disease. In most... more...

Aliases & Classifications for Yellow Fever

About this section
Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
yellow fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

yellow fever 8 42 10 44 48 60
jungle yellow fever 8 60
urban yellow fever 8 60
yf 42 48
sylvatic yellow fever 8
yellow fever, sylvan 8
bronze john 48
yellow jack 48


External Ids:

Disease Ontology8 DOID:9682
ICD9CM27 060.9, 060
NCIt39 C35547
MeSH34 D015004
SNOMED-CT via Orphanet57 16541001
ICD10 via Orphanet26 A95.0, A95.1, A95.9
UMLS via Orphanet61 C0043395
MESH via Orphanet35 D015004
ICD1025 A95, A95.0, A95.1

Related Diseases for Yellow Fever

About this section
Sources:
17GeneCards, 18GeneDecks
See all sources

Graphical network of the top 20 diseases related to Yellow Fever:



Diseases related to yellow fever

Clinical Features for Yellow Fever

About this section
Sources:
48Orphanet
See all sources


Symptoms:

48 (show all 38)
  • spontaneous abortions
  • fever
  • headache
  • jaundice
  • loss of appetite
  • muscle pain
  • backache
  • shivers
  • bleeding from the mouth
  • early death/lethality
  • acute hepatic failure
  • acute diarrhea
  • malignant hyperthermia
  • renal failure
  • dehydration/hydroelectrolytic loss
  • proteinuria
  • renal disease/nephropathy
  • photophobia
  • obnubilation/coma/lethargia/desorientation
  • encephalitis
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • hypothermia
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • hypotension
  • fever/chilling
  • articular/joint pain/arthralgia
  • meningitis/meningeal syndrome
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • anorexia
  • facial pain/cephalalgia/migraine
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • acute abdominal pain/colic
  • myalgia/muscular pain
  • thoracic/chest pain
  • heart/cardiac failure
  • hepatitis/icterus/cholestasis
  • cardiac rhythm disorder/arrhythmia
  • nausea/vomiting/regurgitation/merycism/hyperemesis

Drugs & Therapeutics for Yellow Fever

About this section
Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
See all sources

Approved drugs:

Search CenterWatch for Yellow Fever

Drug clinical trials:

Search ClinicalTrials for Yellow Fever

Search NIH Clinical Center for Yellow Fever

Search CenterWatch for Yellow Fever

Genetic Tests for Yellow Fever

About this section

Anatomical Context for Yellow Fever

About this section
Sources:
32MalaCards
See all sources

MalaCards organs/tissues related to Yellow Fever:

32
Liver, Testes, Skin, Kidney, Eye, T cells, Heart, Nk cells, Breast, Ovary, Cortex, Brain, Bone marrow, Bone, Endothelial, Salivary gland

Animal Models for Yellow Fever or affiliated genes

About this section

Publications for Yellow Fever

About this section
Sources:
50PubMed
See all sources

Articles related to Yellow Fever:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Recombinant yellow fever viruses elicit CD8+ T cell responses and protective immunity against Trypanosoma cruzi. (23527169)
2013
2
What a rheumatologist needs to know about yellow fever vaccine. (23856798)
2013
3
Historical analysis of the records of sylvan yellow fever in the State of Amazonas, Brazil, from 1996 to 2009. (23740065)
2013
4
Bioassay-guided investigation of two Monarda essential oils as repellents of yellow fever mosquito Aedes aegypti. (23919579)
2013
5
Birth of three stowaway-like MITE families via microhomology-mediated miniaturization of a Tc1/Mariner element in the yellow fever mosquito. (24068652)
2013
6
HUMAN IMPACTS HAVE SHAPED HISTORICAL AND RECENT EVOLUTION IN AEDES AEGYPTI, THE DENGUE AND YELLOW FEVER MOSQUITO. (24111703)
2013
7
Safety of the yellow Fever vaccine: a retrospective study. (24118538)
2013
8
Is There a Risk of Yellow Fever Virus Transmission in South Asian Countries with Hyperendemic Dengue? (24367789)
2013
9
Immunogenicity of seven new recombinant yellow fever viruses 17D expressing fragments of SIVmac239 Gag, Nef, and Vif in Indian rhesus macaques. (23336000)
2013
10
Risk of yellow fever vaccine-associated viscerotropic disease among the elderly: a systematic review. (24079979)
2013
11
Ecological aspects of mosquitoes (Diptera: Culicidae) in the gallery forest of BrasA-lia National Park, Brazil, with an emphasis on potential vectors of yellow fever. (24142367)
2013
12
Vaccine administration decision making: the case of yellow fever vaccine. (22670048)
2012
13
Using next generation sequencing to identify yellow fever virus in Uganda. (21962764)
2012
14
Yellow fever vaccination in organ transplanted patients: is it safe? A multicenter study. (22093046)
2012
15
Docking studies towards exploring antiviral compounds against envelope protein of yellow fever virus. (21369890)
2011
16
Isolation of yellow fever virus (YFV) from naturally infected Haemagogus (Conopostegus) leucocelaenus (diptera, cukicudae) in SALo Paulo State, Brazil, 2009. (21755235)
2011
17
Alboserpin, a factor Xa inhibitor from the mosquito vector of yellow fever, binds heparin and membrane phospholipids and exhibits antithrombotic activity. (21673107)
2011
18
Immune correlates of protection against yellow fever determined by passive immunization and challenge in the hamster model. (21718741)
2011
19
Yellow fever 17D-vectored vaccines expressing Lassa virus GP1 and GP2 glycoproteins provide protection against fatal disease in guinea pigs. (21145373)
2011
20
Stability of yellow fever virus under recombinatory pressure as compared with chikungunya virus. (21826243)
2011
21
Quality improvement in travel medicine: a programme for yellow fever vaccination centres in England, Wales and Northern Ireland. (22340901)
2011
22
William Gorgas: yellow fever meets its nemesis. (21968777)
2011
23
Municipalities of higher vulnerability to Sylvatic Yellow Fever occurrence in the SALo Paulo State, Brazil. (22183458)
2011
24
Infection of hepatocytes with 17-D vaccine-strain yellow fever virus induces a strong pro-inflammatory host response. (21697351)
2011
25
The small nuclear ribonucleoprotein U1A interacts with NS5 from yellow fever virus. (21298455)
2011
26
Yellow fever surveillance and outbreak response: revision of case definitions, October 2010. (21090394)
2010
27
Transgene-mediated suppression of dengue viruses in the salivary glands of the yellow fever mosquito, Aedes aegypti. (20738425)
2010
28
Suspected yellow fever vaccine-associated viscerotropic adverse events (1973 and 1978), United States. (20439976)
2010
29
A case of yellow fever vaccine-associated viscerotropic disease in Ecuador. (20348528)
2010
30
Yellow fever a89 prevention in travellers. (21387857)
2010
31
Transmission of yellow fever vaccine virus through breast-feeding - Brazil, 2009. (20150888)
2010
32
Yellow fever: a reemerging threat. (20513550)
2010
33
Household-based sero-epidemiologic survey after a yellow fever epidemic, Sudan, 2005. (20519615)
2010
34
Does yellow fever 17D vaccine protect against melanoma? (19010368)
2009
35
Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes. (18598196)
2008
36
Bleedings, purges, and vomits: Dr. Benjamin Rush's republican medicine, the bilious remitting yellow-fever epidemic of 1793, and the non-origin of the law of informed consent. (18754398)
2008
37
Recombinant chimeric virus with wild-type dengue 4 virus premembrane and envelope and virulent yellow fever virus Asibi backbone sequences is dramatically attenuated in nonhuman primates. (18266603)
2008
38
The enigma of yellow fever in East Africa. (18615782)
2008
39
Effect of insulin and 20-hydroxyecdysone in the fat body of the yellow fever mosquito, Aedes aegypti. (17967350)
2007
40
Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease. (18023511)
2007
41
Vaccinating in disease-free regions: a vaccine model with application to yellow fever. (17442650)
2007
42
Furor therapeuticus: Benjamin Rush and the Philadelphia yellow fever epidemic of 1793. (17403965)
2007
43
Infectious disease. Resurgence of yellow fever in Africa prompts a counterattack. (17525307)
2007
44
Functional requirements of the yellow fever virus capsid protein. (17526891)
2007
45
Role of the yellow fever virus structural protein genes in viral dissemination from the Aedes aegypti mosquito midgut. (16963758)
2006
46
New tools for surveillance of adult yellow fever mosquitoes: comparison of trap catches with human landing rates in an urban environment. (17019768)
2006
47
Yellow fever virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and induce novel changes in gene expression. (16150475)
2005
48
Yellow fever vaccine and egg allergy. (7751510)
1995
49
Monkeypox, yellow fever: Introduction. (20604407)
1972
50
St. Louis encephalitis in Panama. II. Survey of human blood for antibodies against St. Louis and two related group B viruses, Ilheus and yellow fever. (13742499)
1961

Genetic Variations for Yellow Fever

About this section

Expression for genes affiliated with Yellow Fever

About this section
Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Yellow Fever

Search GEO for disease gene expression data for Yellow Fever.

Pathways for genes affiliated with Yellow Fever

About this section
Sources:
29KEGG, 53Reactome
See all sources

Pathways related to Yellow Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CXCL10, CXCL1, CCL5
210.1CXCL10, CXCL1, CCL5

Compounds for genes affiliated with Yellow Fever

About this section
Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB
See all sources

Compounds related to Yellow Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1poly(i-c)4410.3CCL5, CXCL10, RSAD2
2groalpha4410.2CXCL10, CXCL1, CCL5
3polycarbonate4410.2CXCL10, CXCL1
4tarc4410.1CXCL10, CXCL1, CCL5
5ccl344 2811.1CCL5, CXCL1, CXCL10
6leukotriene b444 59 2412.0CXCL10, CXCL1, CCL5
7cytochalasin449.9CXCL1, CCL5

GO Terms for genes affiliated with Yellow Fever

About this section
Sources:
16Gene Ontology
See all sources

Cellular components related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.5OBP2A, IL1RL1, CXCL10, CXCL1, PRNT, CSPG5

Biological processes related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.1CXCL10, CXCL1, CCL5

Molecular functions related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.1CXCL10, CXCL1, CCL5

Products for genes affiliated with Yellow Fever

About this section
  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Yellow Fever

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet