YF
MCID: YLL002
MIFTS: 59

Yellow Fever (YF) malady

Rare diseases, Infectious diseases categories
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Summaries for Yellow Fever

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CDC:3 Yellow fever virus is found in tropical and subtropical areas in South America and Africa. The virus is transmitted to humans by the bite of an infected mosquito. Yellow fever is a very rare cause of illness in U.S. travelers. Illness ranges in severity from a self-limited febrile illness to severe liver disease with bleeding. Yellow fever disease is diagnosed based on symptoms, physical findings, laboratory testing, and travel history, including the possibility of exposure to infected mosquitoes. There is no specific treatment for yellow fever; care is based on symptoms. Steps to prevent yellow fever virus infection include using insect repellent, wearing protective clothing, and getting vaccinated.

MalaCards based summary: Yellow Fever, also known as sylvatic yellow fever, is related to hepatitis and influenza, and has symptoms including facial pain/cephalalgia/migraine, fever/chilling and nausea/vomiting/regurgitation/merycism/hyperemesis. An important gene associated with Yellow Fever is SCP2 (sterol carrier protein 2), and among its related pathways are TRAF Pathway and TNF signaling pathway. The compounds il 10 and infliximab have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and skin, and related mouse phenotypes are liver/biliary system and hematopoietic system.

Disease Ontology:8 A viral infectious disease that results in infection, has material basis in yellow fever virus, which is transmitted by aedes, transmitted by haemagogus, or transmitted by sabethes species of mosquitoes. the infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

Wikipedia:65 Yellow fever, known historically as yellow jack or yellow plague, is an acute viral disease. In most... more...

Aliases & Classifications for Yellow Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 62UMLS, 27ICD9CM, 34MeSH, 57SNOMED-CT, 39NCIt, 35MESH via Orphanet, 26ICD10 via Orphanet, 63UMLS via Orphanet, 25ICD10
See all sources

Yellow Fever, Aliases & Descriptions:

Name: Yellow Fever 8 42 10 44 48 62
Sylvatic Yellow Fever 8 62
Jungle Yellow Fever 8 62
Urban Yellow Fever 8 62
 
Yf 42 48
Yellow Fever, Sylvan 8
Bronze John 48
Yellow Jack 48


Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Rare diseases, Infectious diseases


Characteristics (Orphanet epidemiological data):

48
yellow fever:
Age of onset: Variable; Age of death: Any age


External Ids:

Disease Ontology8 DOID:9682
ICD9CM27 060, 060.9
MeSH34 D015004
NCIt39 C35547
MESH via Orphanet35 D015004
ICD10 via Orphanet26 A95.0, A95.1, A95.9
UMLS via Orphanet63 C0043395
ICD1025 A95, A95.0, A95.1

Related Diseases for Yellow Fever

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Graphical network of the top 20 diseases related to Yellow Fever:



Diseases related to yellow fever

Symptoms for Yellow Fever

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Symptoms:

48 (show all 30)
  • facial pain/cephalalgia/migraine
  • fever/chilling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hepatitis/icterus/cholestasis
  • thoracic/chest pain
  • proteinuria
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • anorexia
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • spontaneous abortions
  • photophobia
  • acute hepatic failure
  • cardiac rhythm disorder/arrhythmia
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • heart/cardiac failure
  • hypotension
  • renal disease/nephropathy
  • renal failure
  • encephalitis
  • meningitis/meningeal syndrome
  • obnubilation/coma/lethargia/desorientation
  • early death/lethality
  • dehydration/hydroelectrolytic loss
  • hypothermia
  • malignant hyperthermia

HPO human phenotypes related to Yellow Fever:

(show all 25)
id Description Frequency HPO Source Accession
1 migraine hallmark (90%) HP:0002076
2 proteinuria typical (50%) HP:0000093
3 abnormality of the menstrual cycle typical (50%) HP:0000140
4 diarrhea typical (50%) HP:0002014
5 nausea and vomiting typical (50%) HP:0002017
6 abdominal pain typical (50%) HP:0002027
7 anorexia typical (50%) HP:0002039
8 gastrointestinal hemorrhage typical (50%) HP:0002239
9 arthralgia typical (50%) HP:0002829
10 myalgia typical (50%) HP:0003326
11 spontaneous abortion typical (50%) HP:0005268
12 chest pain typical (50%) HP:0100749
13 renal insufficiency occasional (7.5%) HP:0000083
14 nephropathy occasional (7.5%) HP:0000112
15 photophobia occasional (7.5%) HP:0000613
16 meningitis occasional (7.5%) HP:0001287
17 congestive heart failure occasional (7.5%) HP:0001635
18 sudden cardiac death occasional (7.5%) HP:0001645
19 dehydration occasional (7.5%) HP:0001944
20 hypothermia occasional (7.5%) HP:0002045
21 malignant hyperthermia occasional (7.5%) HP:0002047
22 encephalitis occasional (7.5%) HP:0002383
23 hypotension occasional (7.5%) HP:0002615
24 reduced consciousness/confusion occasional (7.5%) HP:0004372
25 acute hepatic failure occasional (7.5%) HP:0006554

Drugs & Therapeutics for Yellow Fever

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Drug clinical trials:

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Search NIH Clinical Center for Yellow Fever

Genetic Tests for Yellow Fever

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Anatomical Context for Yellow Fever

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MalaCards organs/tissues related to Yellow Fever:

32
Liver, Testes, Skin, Kidney, Eye, T cells, Heart, Breast, Nk cells, Bone marrow, Bone, Brain, Cortex, Salivary gland, Ovary, Endothelial

Animal Models for Yellow Fever or affiliated genes

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MGI Mouse Phenotypes related to Yellow Fever:

36
idDescriptionMGI Source AccessionScoreTop Affiliating Genes
1MP:00053708.7LTA, EIF2AK4, SCP2
2MP:00053977.7CXCL10, IL1RL1, EIF2AK4, LTA
3MP:00053877.5LTA, EIF2AK4, IL1RL1, CXCL10, SCP2

Publications for Yellow Fever

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Articles related to Yellow Fever:

(show top 50)    (show all 535)
idTitleAuthorsYear
1
Yellow card or red card: airport tribulations and new developments on yellow fever vaccination. (25018808)
2014
2
Co-administration of live measles and yellow fever vaccines and inactivated pentavalent vaccines is associated with increased mortality compared with measles and yellow fever vaccines only. An observational study from Guinea-Bissau. (24325827)
2014
3
Dynamic viral dissemination in mice infected with yellow fever virus strain 17D. (24027319)
2013
4
Coagulation factors, fibrinogen and plasminogen activator inhibitor-1, are differentially regulated by yellow fever virus infection of hepatocytes. (23639427)
2013
5
Transcutaneous yellow fever vaccination of subjects with or without atopic dermatitis. (24331381)
2013
6
Entomological profile of yellow fever epidemics in the Central African Republic, 2006-2010. (22897918)
2012
7
Methodological issues with the risk of relapse study in patients with multiple sclerosis after yellow fever vaccination. (22232361)
2012
8
Larval midgut modifications associated with Bti resistance in the yellow fever mosquito using proteomic and transcriptomic approaches. (22703117)
2012
9
Epidemiological and laboratory characterization of a yellow fever outbreak in northern Uganda, October 2010-January 2011. (22575876)
2012
10
Advanced yellow fever virus genome detection in point-of-care facilities and reference laboratories. (23052311)
2012
11
A flow cytometry-based assay for quantifying non-plaque forming strains of yellow fever virus. (23028428)
2012
12
Docking studies towards exploring antiviral compounds against envelope protein of yellow fever virus. (21369890)
2011
13
Functional characterization of the octenol receptor neuron on the maxillary palps of the yellow fever mosquito, Aedes aegypti. (21738794)
2011
14
Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. (21301482)
2011
15
Dengue-2 and yellow fever 17DD viruses infect human dendritic cells, resulting in an induction of activation markers, cytokines and chemokines and secretion of different TNF-I+ and IFN-I+ profiles. (21894381)
2011
16
Revised recommendations for yellow fever vaccination for international travellers, 2011. (21969938)
2011
17
The revised global yellow fever risk map and recommendations for vaccination, 2010: consensus of the Informal WHO Working Group on Geographic Risk for Yellow Fever. (21798462)
2011
18
Yellow fever virus envelope protein expressed in insect cells is capable of syncytium formation in lepidopteran cells and could be used for immunodetection of YFV in human sera. (21619598)
2011
19
Evaluation of an oviposition-stimulating kairomone for the yellow fever mosquito, Aedes aegypti, in Recife, Brazil. (20618668)
2010
20
Yellow fever surveillance and outbreak response: revision of case definitions, October 2010. (21090394)
2010
21
Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti. (20100490)
2010
22
Incubation periods of Yellow fever virus. (20595499)
2010
23
Yellow fever in a Brazilian family returning from vacation in an endemic area: relevant clinical features and epidemiological issues. (19930387)
2009
24
Safety of 17D derived yellow fever vaccines. (19309249)
2009
25
A note of caution on yellow fever vaccination during maraviroc treatment: a hypothesis on a potential dangerous interaction. (19165082)
2009
26
Characterization of the yellow fever mosquito sterol carrier protein-2 like 3 gene and ligand-bound protein structure. (19130179)
2009
27
Rio de Janeiro against Aedes aegypti: yellow fever in 1908 and dengue in 2008 - editorial. (19057810)
2008
28
Three-dimensional visualization of cultural clusters in the 1878 yellow fever epidemic of New Orleans. (18721469)
2008
29
Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes. (18598196)
2008
30
Limited replication of yellow fever 17DD and 17D-Dengue recombinant viruses in rhesus monkeys. (18506257)
2008
31
Yellow Fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions. (18199634)
2008
32
Pressure-inactivated yellow fever 17DD virus: implications for vaccine development. (18420285)
2008
33
Yellow fever vaccine: past, present and future. (18847312)
2008
34
Activity of T-1106 in a hamster model of yellow Fever virus infection. (17420215)
2007
35
NMR assignments of the yellow fever virus envelope protein domain III. (19636823)
2007
36
Neurological adverse events temporally associated to mass vaccination against yellow fever in Juiz de Fora, Brazil, 1999-2005. (17316927)
2007
37
Acute viscerotropic disease following vaccination against yellow fever. (17669451)
2007
38
Fulminant hepatic failure in northern Brazil: morphological, immunohistochemical and pathogenic aspects of LA!brea hepatitis and yellow fever. (17568643)
2007
39
Effect of insulin and 20-hydroxyecdysone in the fat body of the yellow fever mosquito, Aedes aegypti. (17967350)
2007
40
Fatal multiorgan failure due to yellow fever vaccine-associated viscerotropic disease. (18023511)
2007
41
Yellow fever situation in Africa and South America, 2005. (16924775)
2006
42
Molecular characterization of insulin-like peptides in the yellow fever mosquito, Aedes aegypti: expression, cellular localization, and phylogeny. (16934367)
2006
43
Experimental infection of Culex annulirostris, Culex gelidus, and Aedes vigilax with a yellow fever/Japanese encephalitis virus vaccine chimera (ChimeriVax-JE). (17038690)
2006
44
Analysis of two imported cases of yellow fever infection from Ivory Coast and The Gambia to Germany and Belgium. (16036176)
2005
45
Yellow fever virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and induce novel changes in gene expression. (16150475)
2005
46
Construction of yellow fever/St. Louis encephalitis chimeric virus and the use of chimeras as a diagnostic tool. (15569798)
2004
47
Wild terrestrial rainforest mammals as potential reservoirs for flaviviruses (yellow fever, dengue 2 and St Louis encephalitis viruses) in French Guiana. (15138077)
2004
48
Isolation and expression of a sterol carrier protein-2 gene from the yellow fever mosquito, Aedes aegypti. (12542635)
2003
49
An open randomized study of inactivated hepatitis A vaccine administered concomitantly with typhoid fever and yellow fever vaccines. (12044272)
2002
50
Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis. (6119288)
1981

Variations for Yellow Fever

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Expression for genes affiliated with Yellow Fever

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Expression patterns in normal tissues for genes affiliated with Yellow Fever

Search GEO for disease gene expression data for Yellow Fever.

Pathways for genes affiliated with Yellow Fever

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Pathways related to Yellow Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
1
Show member pathways
9.4LTA, IL1RL1
29.3LTA, CXCL10
3
Show member pathways
Transcription NF kB signaling pathway60
Immune response Toll like receptor TLR ligands and common TLR signaling pathway leading to cell proinflammatory response60
9.3LTA, CXCL10
4
Show member pathways
8.5LTA, EIF2AK4, CXCL10

Compounds for genes affiliated with Yellow Fever

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Sources:
44Novoseek, 50PharmGKB, 11DrugBank, 28IUPHAR, 24HMDB
See all sources

Compounds related to Yellow Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1il 10449.4LTA, CXCL10
2infliximab44 50 1111.4LTA, CXCL10
3allergens449.3SCP2, CXCL10
4neopterin449.3LTA, CXCL10
5endotoxin449.3LTA, CXCL10
6cholesterol44 28 24 1111.6LTA, CXCL10, SCP2

GO Terms for genes affiliated with Yellow Fever

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Cellular components related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1external side of plasma membraneGO:0098979.3IL1RL1, CXCL10

Biological processes related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1response to lipopolysaccharideGO:0324969.0LTA, CXCL10
2signal transductionGO:0071658.8LTA, IL1RL1, CXCL10

Molecular functions related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1receptor bindingGO:0051028.9LTA, CXCL10, SCP2

Products for genes affiliated with Yellow Fever

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  • Antibodies
  • Proteins
  • Lysates

Sources for Yellow Fever

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
62UMLS
63UMLS via Orphanet