YF
MCID: YLL002
MIFTS: 53

Yellow Fever (YF) malady

Infectious category

Summaries for Yellow Fever

Sources:
8Disease Ontology, 3CDC, 64Wikipedia, 33MalaCards
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CDC:3 Yellow fever virus is found in tropical and subtropical areas in South America and Africa. The virus is transmitted to humans by the bite of an infected mosquito. Yellow fever is a very rare cause of illness in U.S. travelers. Illness ranges in severity from a self-limited febrile illness to severe liver disease with bleeding. Yellow fever disease is diagnosed based on symptoms, physical findings, laboratory testing, and travel history, including the possibility of exposure to infected mosquitoes. There is no specific treatment for yellow fever; care is based on symptoms. Steps to prevent yellow fever virus infection include using insect repellent, wearing protective clothing, and getting vaccinated.

MalaCards: Yellow Fever, also known as jungle yellow fever, is related to atopic dermatitis and q fever, and has symptoms including facial pain/cephalalgia/migraine, fever/chilling and nausea/vomiting/regurgitation/merycism/hyperemesis. An important gene associated with Yellow Fever is SCP2 (sterol carrier protein 2), and among its related pathways are TNF signaling pathway and Chemokine receptors bind chemokines. The compounds poly(i-c) and groalpha have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, brain and cortex.

Disease Ontology:8 A viral infectious disease that results in infection, has material basis in yellow fever virus, which is transmitted by aedes, transmitted by haemagogus, or transmitted by sabethes species of mosquitoes. the infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

Wikipedia:64 Yellow fever, known historically as Yellow Jack, is an acute viral hemorrhagic disease. The virus is a... more...

Aliases & Classifications for Yellow Fever

Sources:
8Disease Ontology, 43NIH Rare Diseases, 10DISEASES, 45Novoseek, 49Orphanet, 61UMLS, 57SNOMED-CT, 27ICD9CM, 40NCIt, 35MeSH, 26ICD10 via Orphanet, 58SNOMED-CT via Orphanet, 62UMLS via Orphanet, 36MESH via Orphanet, 25ICD10
See all sources

Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious


Characteristics (Orphanet epidemiological data):

49
yellow fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

yellow fever 8 43 10 45 49 61
jungle yellow fever 8 61
urban yellow fever 8 61
yf 43 49
sylvatic yellow fever 8
yellow fever, sylvan 8
bronze john 49
yellow jack 49


External Ids:

Disease Ontology8 DOID:9682
ICD9CM27 060.9, 060
NCIt40 C35547
MeSH35 D015004
ICD10 via Orphanet26 A95
SNOMED-CT via Orphanet58 16541001
UMLS via Orphanet62 C0043395
MESH via Orphanet36 D015004
ICD1025 A95, A95.0, A95.1

Related Diseases for Yellow Fever

Sources:
17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Yellow Fever:



Diseases related to yellow fever

Clinical Features for Yellow Fever

Sources:
49Orphanet
See all sources


Symptoms:

49 (show all 38)
  • facial pain/cephalalgia/migraine
  • fever/chilling
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • acute abdominal pain/colic
  • acute diarrhea
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • hepatitis/icterus/cholestasis
  • thoracic/chest pain
  • proteinuria
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • anorexia
  • myalgia/muscular pain
  • articular/joint pain/arthralgia
  • spontaneous abortions
  • photophobia
  • acute hepatic failure
  • cardiac rhythm disorder/arrhythmia
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • heart/cardiac failure
  • hypotension
  • renal disease/nephropathy
  • renal failure
  • encephalitis
  • meningitis/meningeal syndrome
  • obnubilation/coma/lethargia/desorientation
  • early death/lethality
  • dehydration/hydroelectrolytic loss
  • hypothermia
  • malignant hyperthermia
  • fever
  • muscle pain
  • backache
  • headache
  • shivers
  • loss of appetite
  • jaundice
  • bleeding from the mouth

Drugs & Therapeutics for Yellow Fever

Sources:
5CenterWatch, 42NIH Clinical Center, 6ClinicalTrials, 61UMLS, 41NDF-RT
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Approved drugs:

Search CenterWatch for Yellow Fever

Drug clinical trials:

Search ClinicalTrials for Yellow Fever

Search NIH Clinical Center for Yellow Fever

Search CenterWatch for Yellow Fever

Genetic Tests for Yellow Fever

Anatomical Context for Yellow Fever

Sources:
33MalaCards
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MalaCards organs/tissues related to Yellow Fever:

33
Bone marrow, Brain, Cortex, Kidney, Liver, Salivary gland, Breast, Skin, Ovary, Nk cells, T cells, B cells, Endothelial, Temporal lobe

Animal Models for Yellow Fever or affiliated genes

Sources:
28inGenious Targeting Laboratory
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Publications for Yellow Fever

Sources:
51PubMed
See all sources

Articles related to Yellow Fever:

(show top 50)    (show all 518)
idTitleAuthorsYear
1
Travel characteristics and yellow fever vaccine usage among US Global TravEpiNet travelers visiting countries with risk of yellow fever virus transmission, 2009-2011. (23458961)
2013
2
Yellow fever vaccine: comparison of the neurovirulence of new 17D-204 Stamarila8c seed lots and RK 168-73 strain. (23763825)
2013
3
Yellow fever revaccination guidelines change - a decision too feverish? (23927031)
2013
4
Immunity and immune response, pathology and pathologic changes: progress and challenges in the immunopathology of yellow fever. (23873723)
2013
5
Methodological issues with the risk of relapse study in patients with multiple sclerosis after yellow fever vaccination. (22232361)
2012
6
Isolation of yellow fever virus from mosquitoes in Misiones province, Argentina. (23025694)
2012
7
Clustered lot quality assurance sampling: a tool to monitor immunization coverage rapidly during a national yellow fever and polio vaccination campaign in Cameroon, May 2009. (21418714)
2012
8
Crotoxin and phospholipases Aa88 from Crotalus durissus terrificus showed antiviral activity against dengue and yellow fever viruses. (21723310)
2012
9
Lack of interference by zoster vaccine with the immune response to yellow fever vaccine. (22414038)
2012
10
Immunogenicity and safety of yellow fever vaccine among 115 HIV-infected patients after a preventive immunisation campaign in Mali. (22627101)
2012
11
Intradermal vaccination to protect against yellow fever and influenza. (21416266)
2012
12
Intervene before leaving: clustered lot quality assurance sampling to monitor vaccination coverage at health district level before the end of a yellow fever and measles vaccination campaign in Sierra Leone in 2009. (22676225)
2012
13
Plasma HIV-RNA is the key determinant of long-term antibody persistence after Yellow fever immunization in a cohort of 364 HIV-infected patients. (22267015)
2012
14
Evaluation of chimeric yellow fever 17D/dengue viral replication in ticks. (22925017)
2012
15
Alterations in the Aedes aegypti transcriptome during infection with West Nile, dengue and yellow fever viruses. (21909258)
2011
16
Outbreak news. Yellow fever, Uganda. (21302384)
2011
17
Yellow fever virus vaccine-associated deaths in young women. (22000363)
2011
18
Pre-clinical efficacy and safety of experimental vaccines based on non-replicating vaccinia vectors against yellow fever. (21931732)
2011
19
Differential cytokine responses from primary human Kupffer cells following infection with wild-type or vaccine strain yellow fever virus. (21277609)
2011
20
Detection of yellow fever 17D genome in urine. (21106799)
2011
21
Evaluation of an oviposition-stimulating kairomone for the yellow fever mosquito, Aedes aegypti, in Recife, Brazil. (20618668)
2010
22
Expression profiling and comparative analyses of seven midgut serine proteases from the yellow fever mosquito, Aedes aegypti. (20100490)
2010
23
Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques. (20089645)
2010
24
Walter Reed (1851-1902): on the cause of yellow fever. (20593138)
2010
25
CD8+ gamma-delta TCR+ and CD4+ T cells produce IFN-I^ at 5-7 days after yellow fever vaccination in Indian rhesus macaques, before the induction of classical antigen-specific T cell responses. (20939995)
2010
26
Yellow fever in a Brazilian family returning from vacation in an endemic area: relevant clinical features and epidemiological issues. (19930387)
2009
27
Yellow fever vaccine - how does it work and why do rare cases of serious adverse events take place? (19520559)
2009
28
Anamnestic immune response to dengue and decreased severity of yellow Fever. (20300401)
2009
29
Outbreak news. Yellow fever, Republic of the Congo. (19425251)
2009
30
Short report: Incidence of yellow fever vaccine-associated neurotropic disease. (19996449)
2009
31
Immunogenicity and safety of yellow fever vaccination for 102 HIV-infected patients. (19191654)
2009
32
Yellow fever vaccination and Kawasaki disease. (19859023)
2009
33
Pressure-inactivated yellow fever 17DD virus: implications for vaccine development. (18420285)
2008
34
An outbreak of yellow fever with concurrent chikungunya virus transmission in South Kordofan, Sudan, 2005. (18502458)
2008
35
Intradermally administered yellow fever vaccine at reduced dose induces a protective immune response: a randomized controlled non-inferiority trial. (18431480)
2008
36
Immune response during adverse events after 17D-derived yellow fever vaccination in Europe. (18419548)
2008
37
The Gr family of candidate gustatory and olfactory receptors in the yellow-fever mosquito Aedes aegypti. (17928357)
2008
38
JAMA patient page. Yellow fever. (18728274)
2008
39
High stability of yellow fever 17D-204 vaccine: a 12-year restrospective analysis of large-scale production. (16914238)
2007
40
Understanding the role of innate immunity in the mechanism of action of the live attenuated Yellow Fever Vaccine 17D. (17191376)
2007
41
Identification of two sterol carrier protein-2 like genes in the yellow fever mosquito, Aedes aegypti. (17433070)
2007
42
nanos gene control DNA mediates developmentally regulated transposition in the yellow fever mosquito Aedes aegypti. (17548819)
2007
43
Yellow fever vaccine-associated viscerotropic disease (YEL-AVD) and corticosteroid therapy: eleven United States cases, 1996-2004. (16896144)
2006
44
Live attenuated chimeric yellow fever dengue type 2 (ChimeriVax-DEN2) vaccine: Phase I clinical trial for safety and immunogenicity: effect of yellow fever pre-immunity in induction of cross neutralizing antibody responses to all 4 dengue serotypes. (17012873)
2006
45
Manipulation of the yellow fever virus non-structural genes 2A and 4B and the 3'non-coding region to evaluate genetic determinants of viral dissemination from the Aedes aegypti midgut. (17172386)
2006
46
Ecdysteroid titers and developmental expression of ecdysteroid-regulated genes during metamorphosis of the yellow fever mosquito, Aedes aegypti (Diptera: Culicidae). (16580015)
2006
47
Comparative toxicity effect of bush tea leaves (Hyptis suaveolens) and orange peel (Citrus sinensis) oil extract on larvae of the yellow fever mosquito Aedes aegypti. (16941944)
2005
48
Carlos Finlay and yellow fever: triumph over adversity. (16435764)
2005
49
Comparison of immunoreactivity to serotonin, FMRFamide and SCPb in the gut and visceral nervous system of larvae, pupae and adults of the yellow fever mosquito Aedes aegypti. (16341252)
2005
50
Replication of dengue, yellow fever, St. Louis encephalitis and vesicular stomatitis viruses in a cell line (TRA-171) derived from Toxorhynchites amboinensis. (6119288)
1981

Genetic Variations for Yellow Fever

Expression for genes affiliated with Yellow Fever

Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
See all sources
Expression patterns in normal tissues for genes affiliated with Yellow Fever

Search GEO for disease gene expression data for Yellow Fever.

Pathways for genes affiliated with Yellow Fever

Sources:
30KEGG, 54Reactome
See all sources

Pathways related to Yellow Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CXCL10, CXCL1, CCL5
210.1CXCL10, CXCL1, CCL5

Compounds for genes affiliated with Yellow Fever

Sources:
45Novoseek, 29IUPHAR, 60Tocris Bioscience, 24HMDB
See all sources

Compounds related to Yellow Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1poly(i-c)4510.3RSAD2, CXCL10, CCL5
2groalpha4510.2CCL5, CXCL1, CXCL10
3polycarbonate4510.2CXCL1, CXCL10
4tarc4510.1CCL5, CXCL1, CXCL10
5ccl345 2911.1CCL5, CXCL1, CXCL10
6leukotriene b445 60 2412.0CCL5, CXCL1, CXCL10
7cytochalasin459.9CXCL1, CCL5

GO Terms for genes affiliated with Yellow Fever

Sources:
16Gene Ontology
See all sources

Cellular components related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.5OBP2A, IL1RL1, CXCL10, CXCL1, PRNT, CSPG5

Biological processes related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.1CXCL10, CXCL1, CCL5

Molecular functions related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.1CXCL10, CXCL1, CCL5

Products for genes affiliated with Yellow Fever

  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Yellow Fever

3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
29IUPHAR
30KEGG
35MeSH
36MESH via Orphanet
37MGI
40NCIt
41NDF-RT
44NINDS
45Novoseek
47OMIM
48OMIM via Orphanet
51PubMed
52QIAGEN
58SNOMED-CT via Orphanet
61UMLS
62UMLS via Orphanet