Yellow Fever malady

CDC: Yellow fever virus is found in tropical and subtropical areas in South America and Africa. The virus is transmitted to humans by the bite of an infected mosquito. Yellow fever is a very rare cause of illness in U.S. travelers. Illness ranges in severity from a self-limited febrile illness to severe liver disease with bleeding. Yellow fever disease is diagnosed based on symptoms, physical findings, laboratory testing, and travel history, including the possibility of exposure to infected mosquitoes. There is no specific treatment for yellow fever; care is based on symptoms. Steps to prevent yellow fever virus infection include using insect repellent, wearing protective clothing, and getting vaccinated.²

MalaCards: Yellow Fever, also known as jungle yellow fever, is related to venezuelan equine encephalitis and smallpox, and has symptoms including fever, muscle pain and backache. An important gene associated with Yellow Fever is SCP2 (sterol carrier protein 2), and among its related pathways are RAR-Gamma-RXR-Alpha Degradation and Rho Family GTPases. The compounds mcp 2 and ivig have been mentioned in the context of this disorder. Affiliated tissues include liver and endothelial, and related mouse phenotypes are hematopoietic system and immune system.

Disease Ontology: A viral infectious disease that results in infection, has material basis in yellow fever virus, which is transmitted by aedes, transmitted by haemagogus, or transmitted by sabethes species of mosquitoes. the infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.⁶

Wikipedia: Yellow fever (also known as Yellow Jack and Bronze John) is an acute viral hemorrhagic disease. The...⁴⁴ more...

Aliases & Descriptions:

yellow fever 6 30 8 32 43 jungle yellow fever 6 43 urban yellow fever 6 43 sylvatic yellow fever 6

yellow fever, sylvan 6 yf 30

Diseases related to yellow fever by text searches and GeneDecks gene sharing:

(show top 50)    (show all 280)

id	Related Disease	Score	Top Affiliating Genes
1	venezuelan equine encephalitis	13.5	FAM46C, DDX60, PRNT, RTP4
2	smallpox	13.2	FBXL15, CCR5, PRNT
3	spotted fever	13.1	CCL5, IGHV4-39, F2, CXCL10
4	syphilis	13.1	CCR5, IGHV4-39, F2
5	pulmonary sarcoidosis	13.0	CCR5, CCL5, LTA
6	allergic contact dermatitis of eyelid	13.0	IL17A, IL5, CXCL10
7	viral encephalitis	13.0	IL6, CCL5, CXCL10
8	crimean-congo hemorrhagic fever	13.0	IL6, IGHV4-39, F2
9	idiopathic pulmonary fibrosis	12.9	IL1RN, CCL5, CXCL1, CXCL10
10	coronary arteriosclerosis	12.9	IL6, CCR5, CCL5
11	bagassosis	12.9	RBBP9, IL5, IL6
12	ruptured abdominal aortic aneurysm	12.9	IL6, F2, HELLS
13	klebsiella	12.8	IL17A, IL1RN, CCR5, CXCL1
14	psoriatic arthritis	12.8	IL1RN, IL6, LTA
15	hepatitis b	12.8	IL17A, CCR5, F2, CXCL10
16	wheat allergic reaction	12.8	IL17A, IL5, CCL5, CXCL10
17	avian influenza	12.8	IL6, CCR5, CXCL10
18	macroglobulinemia	12.7	IL6, CCL5, IGHV4-39, F2
19	typhus	12.7	IL17A, IGHV4-39, CRP
20	subacute sclerosing panencephalitis	12.7	IL17A, IL6, CCL5, IGHV4-39, CXCL10
21	human immunodeficiency virus infectious disease	12.7	IL6, CCR5, CCL5, IGHV4-39
22	hepatitis c	12.7	CCR5, F2, HELLS, CXCL10
23	chikungunya	12.7	IL6, FAM46C, CCL5, IGHV4-39, DDX60, PRNT
24	adult respiratory distress syndrome	12.6	IL1RN, IL6, LTA
25	sydenham's chorea	12.6	CRP, CXCL10
26	interleukin receptor	12.6	IL1RN, IL5, IL6
27	inclusion body myositis	12.6	IL17A, IL1RN, CCR5, CCL5
28	osteolysis	12.5	IL17A, IL1RN, IL6, CXCL10
29	allergic asthma	12.5	IL17A, IL5, CCL5, LTA
30	trypanosomiasis	12.5	IL1RN, IL6, CCL5, IGHV4-39, CXCL10
31	malignant histiocytosis	12.5	F2, CRP, LTA
32	neuritis	12.5	IL5, CCR5, CCL5, LTA, CXCL10
33	primary sclerosing cholangitis	12.5	IL6, CCR5, CCL5, F2
34	rheumatoid arthritis	12.5	IL1RN, CRP, LTA
35	viral meningitis	12.5	IL6, CCL5, CRP
36	aphthous stomatitis	12.5	IL1RN, IL6, CCR5, LTA
37	sclerosing cholangitis	12.5	IL6, CCR5, CCL5, F2
38	hemorrhagic fever with renal syndrome	12.5	IL6, IGHV4-39, CRP, PRNT
39	urolithiasis	12.5	IL1RN, IL6, F2
40	aggressive periodontitis	12.5	IL1RN, IL6, CCL5, LTA
41	cork-handlers' disease	12.4	IL1RN, IL6, F2, CXCL1
42	crohn's disease	12.4	IL17A, IL1RN, IL6, CXCL10
43	dengue disease	12.4	SENP8, RAF1, IGHV4-39, KRAS, PRNT, CSPG5
44	typhoid fever	12.4	IGHV4-39, F2, CRP, LTA
45	atopic dermatitis	12.4	IL17A, IL1RL1, IL5, CCL5, LTA, CXCL10
46	meningoencephalitis	12.4	IL6, CCL5, CRP
47	arteriovenous malformation	12.4	IL17A, IL5, IL6, F2
48	west nile virus	12.4	IL6, CCR5, CCL5, RSAD2, HELLS, CXCL10
49	cerebral palsy	12.4	IL6, CCL5, F2, LTA
50	acute pyelonephritis	12.4	IL6, CRP, CXCL10

Symptoms: fever, muscle pain, backache, headache, shivers, loss of appetite, jaundice, bleeding from the mouth.⁶

Approved drugs:

Drug clinical trials:

MalaCards organs/tissues related to yellow fever:

²²

MGI Mouse Phenotypes related to yellow fever:

²⁵

id	Description	MGI Source Accession	Score	Top Affiliating Genes
1	hematopoietic system phenotype	MP:0005397	8.4	HELLS, KRAS, IL5, IL1RL1, IL17A
2	immune system phenotype	MP:0005387	7.4	RAF1, CXCL10, EIF2AK4, KRAS, RSAD2, F2
3	homeostasis/metabolism phenotype	MP:0005376	6.3	EIF2AK4, LTA, KRAS, RSAD2, CRP, F2

Articles related to yellow fever:

(show all 14)

id	Title	Authors	Year	Affiliating Genes
1	The small nuclear ribonucleoprotein U1A interacts wit h NS5 from yellow fever virus. (21298455)	Bronzoni R.V.... Nogueira M.L.	2011	SNRPA
2	Clinical and immunological insights on severe, advers e neurotropic and viscerotropic disease following 17D yellow fever vaccination. (19906894)	Silva M.L.... Martins-Filho O.A.	2010	IL17A, IL5
3	Response to 'Case of yellow fever vaccine-associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes'. (19281308)	Conesa-Botella A.... Colebunders R.	2009	CCR5, CCL5
4	Systems biology approach predicts immunogenicity of the yellow fever vaccine in humans. (19029902)	Querec T.D.... Pulendran B.	2009	EIF2AK4
5	Identification of odorant-binding proteins of the yellow fever mosquito Aedes aegypti: genome annotation and comparative analyses. (18353104)	Zhou J.J.... Field L.M.	2008	OBP2A
6	Case of yellow fever vaccine--associated viscerotropic disease with prolonged viremia, robust adaptive immune responses, and polymorphisms in CCR5 and RANTES genes. (18598196)	Pulendran B.... Ahmed R.	2008	CCR5, CCL5
7	Treatment of yellow fever. (18061688)	Monath T.P.	2008	HELLS
8	Immune response during adverse events after 17D-derived yellow fever vaccination in Europe. (18419548)	Bae H.G.... Niedrig M.	2008	LTA, CXCL1
9	Experimental yellow fever virus infection in the golden hamster (Mesocricetus auratus) III. Clinical laboratory values. (16760525)	Sbrana E.... Tesh R.B.	2006	F2
10	Yellow fever virus strains Asibi and 17D-204 infect human umbilical cord endothelial cells and induce novel changes in gene expression. (16150475)	Khaiboullina S.F.... St Jeor S.	2005	RSAD2
11	Activation of the cytokine network and unfavorable outcome in patients with yellow fever. (15499539)	er Meulen J.... Kaufmann A.	2004	CXCL10
12	Interindividual variation in the response by fibrinogen, C-reactive protein and interleukin-6 to yellow fever vaccination. (15205588)	Verschuur M.... de Maat M.P.	2004	IL6, CRP
13	Isolation and expression of a sterol carrier protein-2 gene from the yellow fever mosquito, Aedes aegypti. (12542635)	Krebs K.C.... Lan Q.	2003	SCP2
14	Influence of the IL-1Ra gene polymorphism on in vivo synthesis of IL-1Ra and IL-1beta after live yellow fever vaccination. (11531955)	Hacker U.T.... Endres S.	2001	IL1RN, IL1RL1

Genes related to yellow fever according to GeneCards:

(show all 39)

id	Symbol	Description	Score	GeneCards Section Context
1	SCP2	sterol carrier protein 2	11.0	Publications
2	IGHV4-39	immunoglobulin heavy variable 4-39	11.0
3	RTP4	receptor (chemosensory) transporter protein 4	11.0
4	FAM46C	family with sequence similarity 46, member C	11.0	Functions
5	DACT3	dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)	11.0	Disorders
6	OBP2A	odorant binding protein 2A	11.0	Publications
7	ISG20L2	interferon stimulated exonuclease gene 20kDa-like 2	11.0
8	FBXL15	F-box and leucine-rich repeat protein 15	11.0	Disorders
9	RSAD2	radical S-adenosyl methionine domain containing 2	11.0	Functions, Publications
10	PRNT	prion protein (testis specific)	11.0
11	SHKBP1	SH3KBP1 binding protein 1	11.0
12	RBBP9	retinoblastoma binding protein 9	11.0
13	SENP8	SUMO/sentrin specific peptidase family member 8	11.0
14	SLC25A30	solute carrier family 25, member 30	11.0	Disorders
15	CBLL1	Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1	11.0
16	CSPG5	chondroitin sulfate proteoglycan 5 (neuroglycan C)	11.0
17	ST13	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	11.0
18	MAPKAPK5	mitogen-activated protein kinase-activated protein kinase 5	11.0
19	EIF2AK4	eukaryotic translation initiation factor 2 alpha kinase 4	11.0	Publications
20	CXCL1	chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)	11.0	Publications
21	IL1RL1	interleukin 1 receptor-like 1	11.0	Publications
22	SLC44A3	solute carrier family 44, member 3	11.0
23	SNRPA	small nuclear ribonucleoprotein polypeptide A	11.0	Publications
24	DDX60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	11.0
25	CXCL10	chemokine (C-X-C motif) ligand 10	11.0	Publications
26	CCL5	chemokine (C-C motif) ligand 5	11.0	Publications
27	WDHD1	WD repeat and HMG-box DNA binding protein 1	11.0
28	LTA	lymphotoxin alpha (TNF superfamily, member 1)	11.0	Publications
29	HELLS	helicase, lymphoid-specific	11.0	Publications
30	EIF2C3	eukaryotic translation initiation factor 2C, 3	11.0
31	IL17A	interleukin 17A	11.0	Publications
32	CCR5	chemokine (C-C motif) receptor 5 (gene/pseudogene)	11.0	Publications
33	F2	coagulation factor II (thrombin)	11.0	Publications
34	IL5	interleukin 5 (colony-stimulating factor, eosinophil)	11.0	Publications
35	IL1RN	interleukin 1 receptor antagonist	11.0	Publications
36	KRAS	v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog	11.0
37	RAF1	v-raf-1 murine leukemia viral oncogene homolog 1	11.0
38	IL6	interleukin 6 (interferon, beta 2)	11.0	Publications
39	CRP	C-reactive protein, pentraxin-related	11.0	Publications

Pathways related to yellow fever according to GeneDecks:

(show all 21)

id	Pathway	Score	Top Affiliating Genes
1	RAR-Gamma-RXR-Alpha Degradation36	10.0	CCL5, LTA, CXCL1
2	Rho Family GTPases36	9.0	CXCL10, CXCL1, LTA, CCL5, RAF1
3	Rheumatoid arthritis20	8.9	CXCL1, CCL5, IL6, IL17A
4	Cytokine Network36	8.7	IL5, IL6, LTA
5	MIF Mediated Glucocorticoid Regulation36	8.6	CXCL10, CXCL1, LTA, CCL5, IL6, IL5
6	MIF Regulation of Innate Immune Cells36	8.6	CXCL10, CXCL1, LTA, CCL5, IL6, IL5
7	all-trans-Retinoic Acid Signaling in Brain36	8.6	CXCL10, CXCL1, LTA, CCL5, IL6, IL5
8	Chemokine signaling pathway20	8.6	CXCL10, CXCL1, KRAS, CCL5, CCR5, RAF1
9	Influenza A20	8.5	CXCL10, EIF2AK4, RSAD2, CCL5, IL6, RAF1
10	PAK Pathway36	8.5	CXCL10, CXCL1, LTA, CCL5, IL6, IL5
11	Antioxidant Action of Vitamin-C36	8.1	CXCL10, CXCL1, LTA, CCL5, CCR5, IL6
12	p38 Signaling36	8.0	CXCL10, CXCL1, LTA, CCL5, CCR5, MAPKAPK5
13	PEDF Induced Signaling36	8.0	CXCL10, CXCL1, LTA, CCL5, IL6, IL5
14	IL-6 Pathway36	8.0	CXCL10, CXCL1, LTA, CCL5, IL6, IL5
15	MAPK Family Pathway36	8.0	LTA, CCL5, MAPKAPK5, IL6, IL5, RAF1
16	Cytokine-cytokine receptor interaction20	8.0	CXCL10, CXCL1, LTA, CCL5, CCR5, IL6
17	Akt Signaling36	8.0	CXCL10, CXCL1, LTA, CCL5, CCR5, IL6
18	Molecular Mechanisms of Cancer36	7.8	CXCL1, LTA, CCL5, IL6, IL5, RAF1
19	ERK Signaling36	7.7	CXCL1, LTA, CCL5, IL6, IL5, RAF1
20	STAT3 Pathway36	7.7	RAF1, CXCL10, CXCL1, LTA, CCL5, CCR5
21	Endothelin-1 Signaling Pathway36	7.6	CXCL10, CXCL1, LTA, F2, CCL5, IL6

Compounds related to yellow fever according to GeneDecks:

(show top 50)    (show all 59)

id	Compound	Score	Top Affiliating Genes
1	mcp 232	10.2	CCL5, CCR5
2	ivig32	9.8	LTA, CRP, CCR5
3	endotoxin32	9.7	CXCL10, CXCL1, LTA, CRP
4	ccl432	9.6	IL17A, CCR5, CCL5, CXCL10
5	allergens32	9.5	SCP2, IL1RN, IL5, CXCL10
6	tarc32	9.5	CXCL10, CXCL1, CCL5, CCR5, IL5
7	clarithromycin32 9 9	11.5	F2, IL5, IL1RN
8	mip 1alpha32	9.4	CCL5, CCR5, IL6
9	mcp 132	9.3	IL5, IL6, CCL5
10	methacholine32 9 9	11.3	CRP, CCL5, IL5, IL17A
11	amphotericin b32	9.2	CRP, CCL5, IL5, IL1RN
12	fmlp32	9.2	IL1RN, IL5, CCL5, LTA, CXCL1
13	poly(i-c)32	9.1	CXCL10, RSAD2, CCL5, IL6, IL5
14	ccl332	9.0	CXCL10, CXCL1, CCL5, CCR5, IL6
15	pmma32	9.0	IL6, CCL5, CRP
16	tocilizumab32	9.0	CRP, IL6
17	anakinra32 9 9	11.0	CRP, IL6, IL1RN
18	adalimumab32 9 9	10.9	CRP, IL6, IL1RN
19	turpentine32	8.8	CRP, IL6
20	tacrolimus32 34 9 9	11.8	CXCL10, CCL5, IL5, IL17A, RAF1
21	sb 20358032 42	9.8	CXCL1, CRP, CCL5, IL6, IL17A
22	groalpha32	8.8	CXCL10, CXCL1, CCL5, CCR5, IL6, IL17A
23	polyacrylamide32	8.8	SCP2, IL1RN, CCR5, KRAS, HELLS
24	heparin32 9 18 9	11.7	CXCL1, F2, CCL5, IL1RN, RAF1
25	hydrocortisone32 9 9	10.7	CXCL10, CCL5, IL6, IL5, IL1RN
26	neopterin32	8.6	CXCL10, LTA, CRP, IL6, IL1RN
27	leukotriene b432 42 18	10.5	CXCL10, CXCL1, CCL5, IL6, IL5, IL1RN
28	etanercept32 9 9	10.5	LTA, CRP, IL6, IL1RN, IL17A
29	ly29400232	8.4	KRAS, CRP, CCL5, IL6, IL17A
30	prednisolone32 9 9	10.3	IL1RN, IL5, IL6, CRP, LTA
31	aspirin32 34 18	10.3	CRP, F2, CCL5, IL1RN, RAF1
32	il 1032	8.2	IL1RN, CXCL10, LTA, CCL5, CCR5, IL6
33	infliximab32 9 9	10.1	CXCL10, CXCL1, LTA, CRP, IL6, IL1RN
34	simvastatin32 34 42 9 18 9	13.1	CRP, F2, CCL5, CCR5, IL6, IL1RN
35	cholesterol32 9 18 9	10.8	CXCL10, LTA, CRP, CCL5, CCR5, IL6
36	creatinine32	7.7	CXCL10, CRP, F2, CCL5, IL6, IL1RN
37	indomethacin32 9 9	9.7	LTA, CCL5, IL6, IL5, IL1RN, IL17A
38	rantes32	7.6	CXCL10, CXCL1, LTA, CCL5, CCR5, IL6
39	vitamin d32	7.6	CXCL10, LTA, KRAS, CCL5, CCR5, IL6
40	methotrexate32 34 42 9 9	11.6	CXCL1, CRP, F2, CCL5, IL6, IL5
41	histamine32 18	8.6	CXCL10, CXCL1, CCL5, CCR5, IL6, IL5
42	cycloheximide32	7.1	CXCL10, CXCL1, LTA, CRP, CCL5, IL6
43	pge232	7.0	CXCL10, CXCL1, LTA, CCL5, CCR5, IL6
44	dexamethasone32 42 34 9 9	11.0	CXCL10, CXCL1, LTA, CCL5, CCR5, IL6
45	alanine32	6.9	CXCL10, HELLS, CRP, F2, CCL5, CCR5
46	cyclosporin a32 42	7.9	CXCL1, LTA, F2, CCL5, CCR5, IL6
47	estrogen32	6.5	CXCL10, CXCL1, LTA, KRAS, F2, CCL5
48	retinoic acid32 42 18	8.5	CXCL10, CXCL1, HELLS, LTA, KRAS, CCL5
49	vegf32	6.3	CXCL10, CXCL1, LTA, KRAS, CRP, CCL5
50	tyrosine32	5.8	CXCL10, CXCL1, HELLS, LTA, KRAS, CCL5

Cellular components related to yellow fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:005615	6.4	IL17A, CXCL1, LTA, CRP, F2, CCL5

Biological processes related to yellow fever according to GeneDecks:

(show all 9)

id	Name	GO ID	Score	Top Affiliating Genes
1	chemotaxis	GO:006935	9.2	CXCL10, CXCL1, CCL5, CCR5
2	defense response to virus	GO:051607	9.1	CXCL10, RSAD2, DDX60, IL6
3	cell-cell signaling	GO:007267	9.1	IL17A, CCR5, CCL5, LTA, CXCL10
4	positive regulation of JAK-STAT cascade	GO:046427	9.1	IL5, IL6, CCL5
5	MAPK cascade	GO:000165	8.8	KRAS, CCL5, CCR5, MAPKAPK5, RAF1
6	acute-phase response	GO:006953	8.4	IL1RN, IL6, F2, CRP
7	immune response	GO:006955	8.4	CXCL10, CXCL1, CCR5, IL5, IL1RN, IL1RL1
8	response to glucocorticoid stimulus	GO:051384	8.3	KRAS, CCL5, IL6, IL1RN
9	inflammatory response	GO:006954	7.6	IL17A, CXCL10, CXCL1, CRP, CCL5, CCR5

Molecular functions related to yellow fever according to GeneDecks:

id	Name	GO ID	Score	Top Affiliating Genes
1	growth factor activity	GO:008083	8.2	IL5, IL6, F2, CXCL1, CSPG5
2	protein binding	GO:005515	5.3	DDX60, SNRPA, CRP, RSAD2, KRAS, EIF2C3