YF
MCID: YLL002
MIFTS: 57

Yellow Fever (YF) malady

Infectious diseases category

Summaries for Yellow Fever

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8Disease Ontology, 3CDC, 63Wikipedia, 32MalaCards
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CDC:3 Yellow fever virus is found in tropical and subtropical areas in South America and Africa. The virus is transmitted to humans by the bite of an infected mosquito. Yellow fever is a very rare cause of illness in U.S. travelers. Illness ranges in severity from a self-limited febrile illness to severe liver disease with bleeding. Yellow fever disease is diagnosed based on symptoms, physical findings, laboratory testing, and travel history, including the possibility of exposure to infected mosquitoes. There is no specific treatment for yellow fever; care is based on symptoms. Steps to prevent yellow fever virus infection include using insect repellent, wearing protective clothing, and getting vaccinated.

MalaCards: Yellow Fever, also known as jungle yellow fever, is related to encephalitis and atopic dermatitis, and has symptoms including malignant hyperthermia, fever and muscle pain. An important gene associated with Yellow Fever is SCP2 (sterol carrier protein 2), and among its related pathways are TNF signaling pathway and Chemokine receptors bind chemokines. The compounds poly(i-c) and groalpha have been mentioned in the context of this disorder. Affiliated tissues include liver, testes and skin.

Disease Ontology:8 A viral infectious disease that results in infection, has material basis in yellow fever virus, which is transmitted by aedes, transmitted by haemagogus, or transmitted by sabethes species of mosquitoes. the infection has symptom fever, has symptom muscle pain, has symptom backache, has symptom headache, has symptom shivers, has symptom loss of appetite, has symptom jaundice, and has symptom bleeding from the mouth, nose, eyes or stomach leading to vomitus containing blood.

Wikipedia:63 Yellow fever, known historically as yellow jack, or yellow plague is an acute viral disease. In most... more...

Aliases & Classifications for Yellow Fever

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Sources:
8Disease Ontology, 42NIH Rare Diseases, 10DISEASES, 44Novoseek, 48Orphanet, 60UMLS, 56SNOMED-CT, 27ICD9CM, 39NCIt, 34MeSH, 57SNOMED-CT via Orphanet, 26ICD10 via Orphanet, 61UMLS via Orphanet, 35MESH via Orphanet, 25ICD10
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Global: Infectious diseases


Characteristics (Orphanet epidemiological data):

48
yellow fever:
Age of onset: Variable; Age of death: Any age


Aliases & Descriptions:

yellow fever 8 42 10 44 48 60
jungle yellow fever 8 60
urban yellow fever 8 60
yf 42 48
sylvatic yellow fever 8
yellow fever, sylvan 8
bronze john 48
yellow jack 48


External Ids:

Disease Ontology8 DOID:9682
ICD9CM27 060.9, 060
NCIt39 C35547
MeSH34 D015004
SNOMED-CT via Orphanet57 16541001
ICD10 via Orphanet26 A95.0, A95.1, A95.9
UMLS via Orphanet61 C0043395
MESH via Orphanet35 D015004
ICD1025 A95, A95.0, A95.1

Related Diseases for Yellow Fever

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17GeneCards, 18GeneDecks
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Graphical network of the top 20 diseases related to Yellow Fever:



Diseases related to yellow fever

Clinical Features for Yellow Fever

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48Orphanet
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Symptoms:

48 (show all 38)
  • malignant hyperthermia
  • fever
  • muscle pain
  • backache
  • headache
  • shivers
  • loss of appetite
  • jaundice
  • bleeding from the mouth
  • hepatitis/icterus/cholestasis
  • hypothermia
  • dehydration/hydroelectrolytic loss
  • early death/lethality
  • myalgia/muscular pain
  • anorexia
  • metrorrhagia/menorrhagia/hemorrhagic cycles/hyper/poly/spanio/dysmenorrhea
  • pollakiuria/polyuria/dysuria/anuria/acute urine retention/oliguria
  • proteinuria
  • thoracic/chest pain
  • gastrointestinal bleeding/hemorrhage/hematemesis/melena/rectorrhagia
  • acute diarrhea
  • acute abdominal pain/colic
  • nausea/vomiting/regurgitation/merycism/hyperemesis
  • fever/chilling
  • articular/joint pain/arthralgia
  • spontaneous abortions
  • obnubilation/coma/lethargia/desorientation
  • meningitis/meningeal syndrome
  • encephalitis
  • renal failure
  • renal disease/nephropathy
  • hypotension
  • heart/cardiac failure
  • collapse/sudden death/cardiac arrest/cardiorespiratory arrest
  • cardiac rhythm disorder/arrhythmia
  • acute hepatic failure
  • photophobia
  • facial pain/cephalalgia/migraine

Drugs & Therapeutics for Yellow Fever

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

Search ClinicalTrials for Yellow Fever

Search NIH Clinical Center for Yellow Fever

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Genetic Tests for Yellow Fever

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Anatomical Context for Yellow Fever

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32MalaCards
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MalaCards organs/tissues related to Yellow Fever:

32
Liver, Testes, Skin, Kidney, Eye, T cells, Heart, Nk cells, Breast, Bone, Endothelial, Bone marrow, Cortex, Salivary gland, Brain, Ovary

Animal Models for Yellow Fever or affiliated genes

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Publications for Yellow Fever

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Sources:
50PubMed
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Articles related to Yellow Fever:

(show top 50)    (show all 517)
idTitleAuthorsYear
1
Co-administration of live measles and yellow fever vaccines and inactivated pentavalent vaccines is associated with increased mortality compared with measles and yellow fever vaccines only. An observational study from Guinea-Bissau. (24325827)
2014
2
Vaccines and vaccination against yellow fever. WHO position paper -- June 2013. (23909008)
2013
3
How Brazil joined the quest for a yellow fever vaccine. Interview by Claudia Jurberg and Julia D'Aloisio.. (23476088)
2013
4
Identification of three H-2K(d) restricted CTL epitopes of NS4A and NS4B protein from Yellow fever 17D vaccine. (23123122)
2013
5
Dissection of antibody specificities induced by yellow fever vaccination. (23818856)
2013
6
Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response. (23338234)
2013
7
Persistence of yellow fever vaccine-induced antibodies after solid organ transplantation. (23834702)
2013
8
THAP and ATF-2 regulated sterol carrier protein-2 promoter activities in the larval midgut of the yellow fever mosquito, Aedes aegypti. (23056538)
2012
9
First international external quality assessment study on molecular and serological methods for yellow fever diagnosis. (22570700)
2012
10
Docking Studies of Adenosine Analogues with NS5 Methyltransferase of Yellow Fever Virus. (23449064)
2012
11
Insights into human CD8(+) T-cell memory using the yellow fever and smallpox vaccines. (21301482)
2011
12
Defects in coatomer protein I (COPI) transport cause blood feeding-induced mortality in Yellow Fever mosquitoes. (21628559)
2011
13
Moment-to-moment flight manoeuvres of the female yellow fever mosquito (Aedes aegypti L.) in response to plumes of carbon dioxide and human skin odour. (21957112)
2011
14
Identification and characterization of two arylalkylamine N-acetyltransferases in the yellow fever mosquito, Aedes aegypti. (21645618)
2011
15
Fresh, dried or smoked? Repellent properties of volatiles emitted from ethnomedicinal plant leaves against malaria and yellow fever vectors in Ethiopia. (22182798)
2011
16
Transcellular and paracellular pathways of transepithelial fluid secretion in Malpighian (renal) tubules of the yellow fever mosquito Aedes aegypti. (20946239)
2011
17
Yellow fever vaccine seroconversion in travelers. (21976582)
2011
18
Distinctive TLR7 signaling, type I IFN production, and attenuated innate and adaptive immune responses to yellow fever virus in a primate reservoir host. (21515797)
2011
19
Reporting rates of yellow fever vaccine 17D or 17DD-associated serious adverse events in pharmacovigilance data bases: systematic review. (22122389)
2011
20
Incubation periods of Yellow fever virus. (20595499)
2010
21
Circulation of antibodies against yellow fever virus in a simian population in the area of Porto Primavera Hydroelectric Plant, SALo Paulo, Brazil. (20305949)
2010
22
The Aquaporin gene family of the yellow fever mosquito, Aedes aegypti. (21249121)
2010
23
Yellow fever - prevention in travellers. (20877751)
2010
24
Inactivated yellow fever 17D vaccine: development and nonclinical safety, immunogenicity and protective activity. (20347059)
2010
25
Identification of a dominant endoplasmic reticulum-retention signal in yellow fever virus pre-membrane protein. (19846669)
2010
26
A note of caution on yellow fever vaccination during maraviroc treatment: a hypothesis on a potential dangerous interaction. (19165082)
2009
27
The yellow fever virus vaccine induces a broad and polyfunctional human memory CD8+ T cell response. (19933869)
2009
28
Learning immunology from the yellow fever vaccine: innate immunity to systems vaccinology. (19763148)
2009
29
Serotonin-induced high intracellular pH aids in alkali secretion in the anterior midgut of larval yellow fever mosquito Aedes aegypti L. (19648402)
2009
30
Aedes FADD: a novel death domain-containing protein required for antibacterial immunity in the yellow fever mosquito, Aedes aegypti. (18977438)
2009
31
The anterior midgut of larval yellow fever mosquitoes (Aedes aegypti): effects of amino acids, dicarboxylic acids, and glucose on the transepithelial voltage and strong luminal alkalinization. (19637352)
2009
32
Monitoring adverse events following yellow fever vaccination using an integrated telephone and Internet-based system. (19712766)
2009
33
Limited replication of yellow fever 17DD and 17D-Dengue recombinant viruses in rhesus monkeys. (18506257)
2008
34
Yellow Fever virus NS3 plays an essential role in virus assembly independent of its known enzymatic functions. (18199634)
2008
35
Larvicidal effects of fungal Meroterpenoids in the control of Aedes aegypti L., the main vector of dengue and Yellow fever. (18293447)
2008
36
The revised International Health Regulations (2005): impact on yellow fever vaccination in clinical practice. (18337324)
2008
37
Innate immunity phenotypic features point toward simultaneous raise of activation and modulation events following 17DD live attenuated yellow fever first-time vaccination. (18243433)
2008
38
Yellow fever vaccines and international travelers. (18564013)
2008
39
A transgenic sensor strain for monitoring the RNAi pathway in the yellow fever mosquito, Aedes aegypti. (18549956)
2008
40
Identification of odorant-binding proteins of the yellow fever mosquito Aedes aegypti: genome annotation and comparative analyses. (18353104)
2008
41
Early exposure to yellow fever vaccine during pregnancy. (17596249)
2007
42
Outbreak news. Yellow fever, Togo--update. (17310514)
2007
43
Molecular and phenotypic analysis of a working seed lot of yellow fever virus 17DD vaccine strain produced from the secondary seed lot 102/84 with an additional passage in chicken embryos. (16326110)
2006
44
Late vaccination against yellow fever of travelers visiting endemic countries. (16887731)
2006
45
Analysis of two imported cases of yellow fever infection from Ivory Coast and The Gambia to Germany and Belgium. (16036176)
2005
46
Killed in action: microbiologists and clinicians as victims of their occupation. Part 2: Yellow fever and bartonellosis. (16128394)
2005
47
Yellow fever immunities in West Africa and the Americas in the age of slavery and beyond: a reappraisal. (17595747)
2001
48
Yaws and yellow fever project--Ghana. (6801453)
1982
49
Effect of previous dengue infection and yellow fever vaccination on St. Louis encephalitis virus serological surveys in Tampa Bay area of Florida. (5934624)
1966
50
Demonstration: Preparations Illustrating the Causes of the Tick Paralysis of British Columbia, Rocky Mountain Fever, Infective Jaundice and Yellow Fever. (20312231)
1920

Genetic Variations for Yellow Fever

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Expression for genes affiliated with Yellow Fever

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Yellow Fever

Search GEO for disease gene expression data for Yellow Fever.

Pathways for genes affiliated with Yellow Fever

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29KEGG, 53Reactome
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Pathways related to Yellow Fever according to GeneCards/GeneDecks:

idSuper pathways (with members indented)ScoreTop Affiliating Genes
110.1CXCL10, CXCL1, CCL5
210.1CXCL10, CXCL1, CCL5

Compounds for genes affiliated with Yellow Fever

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Sources:
44Novoseek, 28IUPHAR, 59Tocris Bioscience, 24HMDB
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Compounds related to Yellow Fever according to GeneCards/GeneDecks:

idCompoundScoreTop Affiliating Genes
1poly(i-c)4410.3CCL5, CXCL10, RSAD2
2groalpha4410.2CXCL10, CXCL1, CCL5
3polycarbonate4410.2CXCL10, CXCL1
4tarc4410.1CXCL10, CXCL1, CCL5
5ccl344 2811.1CCL5, CXCL1, CXCL10
6leukotriene b444 59 2412.0CXCL10, CXCL1, CCL5
7cytochalasin449.9CXCL1, CCL5

GO Terms for genes affiliated with Yellow Fever

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16Gene Ontology
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Cellular components related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1extracellular regionGO:0055769.5OBP2A, IL1RL1, CXCL10, CXCL1, PRNT, CSPG5

Biological processes related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemotaxisGO:00693510.1CXCL10, CXCL1, CCL5

Molecular functions related to Yellow Fever according to GeneCards/GeneDecks:

idNameGO IDScoreTop Affiliating Genes
1chemokine activityGO:00800910.1CXCL10, CXCL1, CCL5

Products for genes affiliated with Yellow Fever

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Yellow Fever

About this section
3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet