MCID: YNG002
MIFTS: 23

Young Syndrome malady

Reproductive diseases, Respiratory diseases categories

Summaries for Young Syndrome

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Sources:
42NIH Rare Diseases, 63Wikipedia, 46OMIM, 32MalaCards
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NIH Rare Diseases:42 Young syndrome is a condition whose signs and symptoms may be similar to those seen in cystic fibrosis, including bronchiectasis, sinusitis, and obstructive azoospermia (a condition in which sperm are produced but do not mix with the rest of the ejaculatory fluid due to a physical obstruction, resulting in nonexistent levels of sperm in semen) . the condition is usually diagnosed in middle-aged men who undergo evaluation for infertility. although the exact cause has not been identified, it is believed to be a genetic condition. at this time, there is no known effective treatment or cure for young syndrome. last updated: 6/24/2009

MalaCards: Young Syndrome, also known as azoospermia obstructive and chronic sinopulmonary infections, is related to stratton-garcia-young syndrome and upton young syndrome, and has symptoms including repeat respiratory infections, structural anomalies of the genital system and sterility/hypofertility. An important gene associated with Young Syndrome is CFTR (cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)). Affiliated tissues include lung and pancreas.

Wikipedia:63 Young\'s syndrome, also known as azoospermia sinopulmonary infections, sinusitis-infertility syndrome... more...

Description from OMIM:46 279000

Aliases & Classifications for Young Syndrome

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Sources:
42NIH Rare Diseases, 44Novoseek, 48Orphanet, 46OMIM, 60UMLS, 35MESH via Orphanet, 57SNOMED-CT via Orphanet, 61UMLS via Orphanet
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Classifications:

Malacards categories (disease lists): (See all malacards categories)
Anatomical: Reproductive diseases, Respiratory diseases


Characteristics (Orphanet epidemiological data):

48
young syndrome:
Inheritance: Autosomal recessive; Age of onset: Adulthood; Age of death: Normal


Aliases & Descriptions:

young syndrome 42 44 48 46 60
azoospermia obstructive and chronic sinopulmonary infections 42
azoospermia - sinopulmonary infections 48
sinusitis-infertility syndrome 42
barry perkins young syndrome 42


External Ids:

OMIM46 279000
MESH via Orphanet35 C536718
SNOMED-CT via Orphanet57 233666007
UMLS via Orphanet61 C0340037

Related Diseases for Young Syndrome

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Sources:
17GeneCards, 18GeneDecks
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Diseases related to Young Syndrome via text searches within MalaCards or GeneCards/GeneDecks gene sharing:

idRelated DiseaseScoreTop Affiliating Genes
1stratton-garcia-young syndrome10.2
2upton young syndrome10.2
3infertility10.1
4polydactyly9.8
5microcephaly9.8

Graphical network of diseases related to Young Syndrome:



Diseases related to young syndrome

Clinical Features for Young Syndrome

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Sources:
46OMIM, 48Orphanet
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Clinical features from OMIM:

279000

Clinical synopsis from OMIM:

279000

Symptoms:

48
  • repeat respiratory infections
  • structural anomalies of the genital system
  • sterility/hypofertility
  • autosomal recessive inheritance
  • structural anomalies of the pancreas

Drugs & Therapeutics for Young Syndrome

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Sources:
5CenterWatch, 41NIH Clinical Center, 6ClinicalTrials, 60UMLS, 40NDF-RT
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Approved drugs:

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Drug clinical trials:

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Genetic Tests for Young Syndrome

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Anatomical Context for Young Syndrome

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Sources:
32MalaCards
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MalaCards organs/tissues related to Young Syndrome:

32
Lung, Pancreas

Animal Models for Young Syndrome or affiliated genes

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Publications for Young Syndrome

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Genetic Variations for Young Syndrome

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Expression for genes affiliated with Young Syndrome

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Sources:
1BioGPS, 15Gene Expression Omnibus DataSets
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Expression patterns in normal tissues for genes affiliated with Young Syndrome

Search GEO for disease gene expression data for Young Syndrome.

Pathways for genes affiliated with Young Syndrome

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Compounds for genes affiliated with Young Syndrome

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GO Terms for genes affiliated with Young Syndrome

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Products for genes affiliated with Young Syndrome

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  • Antibodies
  • Proteins
  • Lysates
  • Antibodies

Sources for Young Syndrome

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3CDC
13ExPASy
14FMA
22GTR
23HGMD
24HMDB
25ICD10
26ICD10 via Orphanet
27ICD9CM
28IUPHAR
29KEGG
34MeSH
35MESH via Orphanet
36MGI
39NCIt
40NDF-RT
43NINDS
44Novoseek
46OMIM
47OMIM via Orphanet
50PubMed
51QIAGEN
57SNOMED-CT via Orphanet
60UMLS
61UMLS via Orphanet