Aliases & Classifications for Young Syndrome

Aliases & Descriptions for Young Syndrome:

Name: Young Syndrome 50 52 69
Azoospermia Obstructive and Chronic Sinopulmonary Infections 50
Azoospermia-Sinopulmonary Infections Syndrome 50
Sinusitis-Infertility Syndrome 50
Barry Perkins Young Syndrome 50

Characteristics:

HPO:

32
young syndrome:
Inheritance autosomal recessive inheritance


Classifications:



Summaries for Young Syndrome

NIH Rare Diseases : 50 young syndrome is a condition characterized by male infertility, damaged airways in the lungs (bronchiectasis), and inflammation of the sinuses (sinusitis). male infertility in young syndrome is secondary to obstructive azoospermia, a condition in which sperm are produced but do not mix with the rest of the ejaculatory fluid, due to a physical obstruction in the epididymis (tube through which sperm exit the testis). this results in nonexistent levels of sperm in semen. young syndrome is typically diagnosed in middle-aged men who undergo evaluation for infertility. as the signs and symptoms of young syndrome are similar to cystic fibrosis (cf), part of the diagnosis process may include ruling out cf. although the exact cause of young syndrome has not been identified, it is believed to either be related to childhood exposure to mercury or genetic factors. while there is no one treatment for young syndrome, management involves treatment of sinus and lung infections. fertility treatment may also be an option, including surgery to remove the obstruction in the epididymis (vasoepididymostomy) or assisted reproduction, such as intracytoplasmic sperm injection (icsi). last updated: 10/4/2016

MalaCards based summary : Young Syndrome, also known as azoospermia obstructive and chronic sinopulmonary infections, is related to brachydactyly-mesomelia-intellectual disability-heart defects syndrome and renal cysts and diabetes syndrome, and has symptoms including azoospermia, bronchiectasis and recurrent bronchitis. An important gene associated with Young Syndrome is CFTR (Cystic Fibrosis Transmembrane Conductance Regulator). The drugs Dopamine and Estradiol have been mentioned in the context of this disorder. Affiliated tissues include lung, testis and pancreas.

Wikipedia : 71 Young\'s syndrome, also known as azoospermia sinopulmonary infections, sinusitis-infertility syndrome... more...

Related Diseases for Young Syndrome

Diseases related to Young Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

id Related Disease Score Top Affiliating Genes
1 brachydactyly-mesomelia-intellectual disability-heart defects syndrome 10.8
2 renal cysts and diabetes syndrome 10.7
3 sinusitis 9.8
4 infertility 9.8
5 microcephaly 9.2
6 polydactyly 9.2

Graphical network of the top 20 diseases related to Young Syndrome:



Diseases related to Young Syndrome

Symptoms & Phenotypes for Young Syndrome

Human phenotypes related to Young Syndrome:

32 (show all 8)
id Description HPO Frequency HPO Source Accession
1 azoospermia 32 HP:0000027
2 bronchiectasis 32 HP:0002110
3 recurrent bronchitis 32 HP:0002837
4 recurrent sinopulmonary infections 32 HP:0005425
5 congenital cystic adenomatoid malformation of the lung 32 HP:0010959
6 decreased fertility 32 HP:0000144
7 abnormality of the pancreas 32 HP:0001732
8 obstructive azoospermia 32 HP:0011962

Drugs & Therapeutics for Young Syndrome

Drugs for Young Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 574)
id Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-61-6, 62-31-7 681
2
Estradiol Approved, Investigational, Vet_approved Phase 4 50-28-2 5757 53477783
3
Ritonavir Approved, Investigational Phase 4,Phase 2,Phase 1 155213-67-5 392622
4
Lopinavir Approved Phase 4,Phase 1 192725-17-0 92727
5
Cyclophosphamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
6
Lamivudine Approved, Investigational Phase 4,Phase 2,Phase 1 134678-17-4 60825
7
Metformin Approved Phase 4,Phase 2,Phase 3 657-24-9 14219 4091
8
Ramipril Approved Phase 4 87333-19-5 5362129
9 Moxonidine Approved Phase 4 75438-57-2 4810
10
Cilostazol Approved Phase 4 73963-72-1 2754
11
Busulfan Approved, Investigational Phase 4,Phase 2,Phase 1 55-98-1 2478
12
Drospirenone Approved Phase 4 67392-87-4 68873
13
Abacavir Approved, Investigational Phase 4,Phase 2,Phase 1 136470-78-5 65140 441300
14
Aripiprazole Approved, Investigational Phase 4,Phase 3 129722-12-9 60795
15
Emtricitabine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 143491-57-0 60877
16
Ethinyl Estradiol Approved Phase 4 57-63-6 5991
17
Fluocinolone Acetonide Approved, Investigational, Vet_approved Phase 4 67-73-2 6215
18
Progesterone Approved, Vet_approved Phase 4 57-83-0 5994
19
Testosterone Approved, Investigational Phase 4 58-22-0 6013
20
Rifampin Approved Phase 4,Phase 1 13292-46-1 5458213 5381226
21
Valproic Acid Approved, Investigational Phase 4,Phase 3 99-66-1 3121
22
Memantine Approved, Investigational Phase 4,Phase 2 19982-08-2 4054
23
Atropine Approved, Vet_approved Phase 4 5908-99-6, 51-55-8 174174
24
Olanzapine Approved, Investigational Phase 4,Phase 3 132539-06-1 4585
25
Risperidone Approved, Investigational Phase 4,Phase 3 106266-06-2 5073
26
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3 76631-46-4, 113775-47-6 68602 5311068 56032
27
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 2 564-25-0 54671203
28
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
29
Ticagrelor Approved Phase 4 274693-27-5 9871419
30
Methyltestosterone Approved Phase 4 58-18-4 6010
31
Chlorpromazine Approved, Vet_approved Phase 4 50-53-3 2726
32
Ticlopidine Approved Phase 4 55142-85-3 5472
33
Everolimus Approved Phase 4,Phase 1,Phase 2 159351-69-6 6442177
34
Sirolimus Approved, Investigational Phase 4,Phase 1,Phase 2 53123-88-9 5284616 6436030 46835353
35
Norgestimate Approved Phase 4 35189-28-7 6540478
36
Moxifloxacin Approved, Investigational Phase 4 354812-41-2, 151096-09-2 152946
37
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
38
Citalopram Approved Phase 4,Phase 3 59729-33-8 2771
39
Melatonin Approved, Nutraceutical, Vet_approved Phase 4 73-31-4 896
40
leucovorin Approved, Nutraceutical Phase 4,Phase 2,Phase 3,Phase 1 58-05-9 54575, 6560146 143
41
Clopidogrel Approved, Nutraceutical Phase 4 120202-66-6, 113665-84-2 60606
42
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1 59-30-3 6037
43 insulin Phase 4,Phase 1,Early Phase 1
44 Estradiol valerate Phase 4 979-32-8
45 Atorvastatin Calcium Phase 4 134523-03-8
46 Rosuvastatin Calcium Phase 4,Phase 2 147098-20-2
47 Prasugrel hydrochloride Phase 4 389574-19-0
48 Analgesics Phase 4,Phase 3,Phase 2,Phase 1
49 calcium channel blockers Phase 4,Phase 2
50 Alkylating Agents Phase 4,Phase 3,Phase 2,Phase 1

Interventional clinical trials:

(show top 50) (show all 618)
id Name Status NCT ID Phase
1 Fixed-dose vs. Phenotype-based PrAsugrel Dose to MATCH Therapeutic Zone in Asians With Acute Coronary Syndrome Unknown status NCT01951001 Phase 4
2 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4
3 Study of the Effect of Moxonidine and Diet on Sympathetic Functions in Young Adults With Obesity Unknown status NCT01180231 Phase 4
4 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4
5 Effects of Cilostazol on Plasma Adipocytokine and Arterial Stiffness Unknown status NCT00573950 Phase 4
6 Statin and Angiotensin-converting Enzyme Inhibitor on Symptoms in Patients With SCAD Unknown status NCT02008786 Phase 4
7 Flucinolone Acetonide Implant for Treating Refractory Ocular Behcet's Disease Unknown status NCT00720928 Phase 4
8 Pilot Study With Isentress (Raltegravir) and Epzicom (Abacavir/Lamivudine) in Treatment Naive HIV-Infected Subjects Unknown status NCT00740064 Phase 4
9 Korean AMADEUS Study Unknown status NCT01239849 Phase 4
10 Efficacy and Safety of Memantine Hydrochloride in Enhancing the Cognitive Abilities of Young Adults With Down Syndrome Completed NCT01112683 Phase 4
11 Growth Hormone Treatment for the Prevention of Short Stature in Young Girls With Turner Syndrome Before the Age of 4 Years Completed NCT01066052 Phase 4
12 Clinical, Metabolic and Endocrine Effects of the Treatment With Drospirenone and Ethinyl Estradiol Alone or in Combination With Myo-inositol in Young Women With Polycystic Ovary Syndrome (PCOS) and Insulin Resistance Completed NCT01511822 Phase 4
13 Metabolic Syndrome Criteria and the Effect of Testosterone Treatment in Young Men With Hypogonadism Completed NCT01160341 Phase 4
14 Randomized Controlled Trial on the Treatment Effects of Melatonin and Light Therapy on Delayed Sleep Phase Syndrome Completed NCT00834886 Phase 4
15 Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome Completed NCT01071044 Phase 4
16 Defining the Optimal Hormonal Replacement Therapy in Turner Syndrome Completed NCT00134745 Phase 4
17 Estrogen Dosing in Turner Syndrome: Pharmacology and Metabolism Completed NCT00837616 Phase 4
18 Metformin in High Responder Polycystic Ovary Syndrome (PCOS) Patients Undergoing IVF Cycles Completed NCT01233206 Phase 4
19 Pharmacokinetics of Lopinavir/Ritonavir Superboosting in Infants and Young Children Co-infected With HIV and TB Completed NCT02348177 Phase 4
20 Different Safety Profile of Risperidone and Paliperidone Extended-release Completed NCT01284959 Phase 4
21 Bone Mineral Density (BMD) in Adolescents With Growth Hormone Deficiency (GHD) Completed NCT00097526 Phase 4
22 A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency Completed NCT01289847 Phase 4
23 Efficacy and Safety of Quetiapine in Treating Affective Symptoms of Patients With First-episode psychosis-a Pilot Study Completed NCT00511277 Phase 4
24 Pregnenolone Augmentation in the Treatment of Patients With Recent-Onset Schizophrenia Completed NCT00847600 Phase 4
25 Role of Myo-inositol and D-chiro Inositol on the Ovaric and Metabolic Functions Completed NCT01626443 Phase 4
26 Erythropoietin in the Prevention of Acute Mountain Sickness Completed NCT01665781 Phase 4
27 Quetiapine Fumarate (Seroquel) as Mono-Therapy or Adjunct to Lithium in the Treatment of Patients With Acute Mania in Bipolar Disorder Completed NCT00672490 Phase 4
28 Study of Depakote ER for the Treatment of Mania in Children Ages 6-12 With Bipolar Disorder Completed NCT00181727 Phase 4
29 Adult Bipolar Mania Completed NCT00931723 Phase 4
30 Dexmedetomidine and Propofol in Children With History of Obstructive Sleep Apnea Completed NCT01344759 Phase 4
31 A Trial Comparing Risperidone Long-Acting Injection With Oral Antipsychotic in the Treatment of Early Psychosis Completed NCT00246259 Phase 4
32 Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics Completed NCT01811160 Phase 4
33 Effectiveness of Integrating Prenatal Care in Reducing HIV/STDs Among Young Pregnant Women Completed NCT00628771 Phase 4
34 Doxycycline In Lymphangioleiomyomatosis (LAM) Completed NCT00989742 Phase 4
35 Understanding the Immune Response to Two Different Meningitis Vaccines Completed NCT01593514 Phase 4
36 4-Day-A-Week Treatment Plan for HIV Infected Adolescents Completed NCT00068809 Phase 4
37 A Study of Aripiprazole (Abilify) in Patients With Bipolar Mania Completed NCT00261443 Phase 4
38 Comparison of Three Hepatitis B Vaccination Regimens in HIV-Positive Youth Completed NCT00106964 Phase 4
39 Metformin for Ectopic Fat Deposition and Metabolic Markers in Polycystic Ovary Syndrome (PCOS) Recruiting NCT02500147 Phase 4
40 Selective Estrogen Receptor Modulators for Women of Child-bearing Age With Schizophrenia Recruiting NCT02354001 Phase 4
41 Oral Contraceptive Therapy and Sexuality Recruiting NCT02613039 Phase 4
42 Safety and Efficacy of Ticagrelor Versus Clopidogrel in Asian/KOREAn Patients With Acute Coronary Syndromes Intended for Invasive Management Recruiting NCT02094963 Phase 4
43 The Effect of DPP4 Inhibitor on Vasclular Healing Recruiting NCT02802644 Phase 4
44 Comparison of Combination Olanzapine+Lithium or Chlorpromazine+Lithium in Treatment of First Manic Episode With Psychotic Features Recruiting NCT00202293 Phase 4
45 Drug-Eluting Stent Implantation Versus Optimal Medical Treatment in Patients With Chronic Total Occlusion (DECISION-CTO) Recruiting NCT01078051 Phase 4
46 Oral Contraceptives in the Metabolic Syndrome Active, not recruiting NCT00205504 Phase 4
47 Busulfan and Cyclophosphamide Instead of Total Boby Irradiation (TBI) and Cyclophosphamide for Hematological Malignancies Hematocrit (HCT) Not yet recruiting NCT01339988 Phase 4
48 Paediatric Ards Neuromuscular Blockade Study Not yet recruiting NCT02902055 Phase 4
49 Escitalopram for Premenstrual Syndrome (PMS) in Teens: A Pilot Study Terminated NCT00523705 Phase 4
50 Evaluation of 3TC or FTC Mono-therapy Compared to Continuing HAART as a Bridging Strategy Terminated NCT01338025 Phase 4

Search NIH Clinical Center for Young Syndrome

Genetic Tests for Young Syndrome

Anatomical Context for Young Syndrome

MalaCards organs/tissues related to Young Syndrome:

39
Lung, Testis, Pancreas

Publications for Young Syndrome

Articles related to Young Syndrome:

id Title Authors Year
1
Screening Young syndrome patients for CFTR mutations. ( 7551394 )
1995
2
Dysmorphology report: on the association of microcephaly and preaxial polydactyly. Another example of Howard-Young syndrome. ( 1472358 )
1992

Variations for Young Syndrome

Expression for Young Syndrome

Search GEO for disease gene expression data for Young Syndrome.

Pathways for Young Syndrome

GO Terms for Young Syndrome

Sources for Young Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
16 ExPASy
18 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 MedGen
42 MeSH
43 MESH via Orphanet
44 MGI
46 NCI
47 NCIt
48 NDF-RT
51 NINDS
52 Novoseek
54 OMIM
55 OMIM via Orphanet
59 PubMed
60 QIAGEN
65 SNOMED-CT via Orphanet
67 TGDB
68 Tocris
69 UMLS
70 UMLS via Orphanet
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