MCID: 1CH001
MIFTS: 20

1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Categories: Immune diseases, Skin diseases

Aliases & Classifications for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

MalaCards integrated aliases for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis:

Name: 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis 12 15
Allergic Contact Dermatitis to Dinitrochlorobenzene 12
Allergic Contact Dermatitis to Dncb 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040069

Summaries for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Disease Ontology : 12 An allergic contact dermatitis that has allergic trigger 1-chloro-2,4-dinitrobenzene.

MalaCards based summary : 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis, also known as allergic contact dermatitis to dinitrochlorobenzene, is related to dermatitis and contact dermatitis. An important gene associated with 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis is IL4 (Interleukin 4), and among its related pathways/superpathways are T cell receptor signaling pathway and Th17 cell differentiation.

Related Diseases for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Diseases related to 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 dermatitis 30.3 IL4 IL2
2 contact dermatitis 30.2 IL4 IL2
3 allergic disease 30.1 IL4 IL2
4 allergic contact dermatitis 10.2
5 virus associated hemophagocytic syndrome 9.9 IL4 IL2
6 chromium allergic contact dermatitis 9.9 IL4 IL2
7 jak3-deficient severe combined immunodeficiency 9.9 IL4 IL2
8 severe combined immunodeficiency 9.9 IL4 IL2
9 atopic keratoconjunctivitis 9.9 IL4 IL2
10 keratoconjunctivitis 9.9 IL4 IL2
11 conjunctivitis 9.9 IL4 IL2
12 metal allergy 9.9 IL4 IL2
13 chronic asthma 9.9 IL4 IL2
14 nickel allergic contact dermatitis 9.9 IL4 IL2
15 angiostrongyliasis 9.9 IL4 IL2
16 mucocutaneous leishmaniasis 9.9 IL4 IL2
17 cutaneous leishmaniasis 9.9 IL4 IL2
18 leishmaniasis 9.9 IL4 IL2
19 taeniasis 9.9 IL4 IL2
20 autoimmune vasculitis 9.9 IL4 IL2
21 fungal meningitis 9.9 IL4 IL2
22 meningitis 9.9 IL4 IL2
23 filarial elephantiasis 9.9 IL4 IL2
24 eosinophilic meningitis 9.9 IL4 IL2
25 primary systemic mycosis 9.9 IL4 IL2
26 acute graft versus host disease 9.9 IL4 IL2
27 autoimmune disease of eyes, ear, nose and throat 9.9 IL4 IL2
28 intestinal schistosomiasis 9.9 IL4 IL2
29 schistosomiasis 9.9 IL4 IL2
30 periapical granuloma 9.9 IL4 IL2
31 lichen disease 9.9 IL4 IL2
32 microscopic colitis 9.9 IL4 IL2
33 colitis 9.9 IL4 IL2
34 autoimmune gastritis 9.9 IL4 IL2
35 erythema multiforme 9.9 IL4 IL2
36 vulvovaginal candidiasis 9.9 IL4 IL2
37 candidiasis 9.9 IL4 IL2
38 autoimmune disease of blood 9.9 IL4 IL2
39 chickenpox 9.9 IL4 IL2
40 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 9.9 IL4 IL2
41 herpangina 9.9 IL4 IL2
42 conjunctival disease 9.9 IL4 IL2
43 splenic disease 9.9 IL4 IL2
44 coccidiosis 9.9 IL4 IL2
45 posterior uveitis 9.9 IL4 IL2
46 uveitis 9.9 IL4 IL2
47 onchocerciasis 9.9 IL4 IL2
48 subacute sclerosing panencephalitis 9.9 IL4 IL2
49 leptospirosis 9.9 IL4 IL2
50 paracoccidioidomycosis 9.9 IL4 IL2

Graphical network of the top 20 diseases related to 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis:



Diseases related to 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Symptoms & Phenotypes for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Drugs & Therapeutics for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Search Clinical Trials , NIH Clinical Center for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Genetic Tests for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Anatomical Context for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Publications for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Articles related to 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis:

# Title Authors PMID Year
1
Inhibition of allergic contact dermatitis to DNCB but not to oxazolone in interleukin-4-deficient mice. 61
10201532 1999

Variations for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Expression for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Search GEO for disease gene expression data for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis.

Pathways for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Pathways related to 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.13 IL4 IL2
2
Show member pathways
12.11 IL4 IL2
3 12.07 IL4 IL2
4
Show member pathways
12.02 IL4 IL2
5
Show member pathways
11.93 IL4 IL2
6
Show member pathways
11.86 IL4 IL2
7
Show member pathways
11.78 IL4 IL2
8 11.59 IL4 IL2
9 11.56 IL4 IL2
10
Show member pathways
11.53 IL4 IL2
11 11.37 IL4 IL2
12 11.34 IL4 IL2
13
Show member pathways
11.28 IL4 IL2
14 11.23 IL4 IL2
15
Show member pathways
11.15 IL4 IL2
16 10.92 IL4 IL2
17 10.67 IL4 IL2
18 10.42 IL4 IL2
19 10.04 IL4 IL2

GO Terms for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

Biological processes related to 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.46 IL4 IL2
2 negative regulation of inflammatory response GO:0050728 9.43 IL4 IL2
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.4 IL4 IL2
4 positive regulation of T cell proliferation GO:0042102 9.37 IL4 IL2
5 positive regulation of B cell proliferation GO:0030890 9.32 IL4 IL2
6 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.26 IL4 IL2
7 positive regulation of T cell differentiation GO:0045582 9.16 IL4 IL2
8 negative regulation of T-helper 17 cell differentiation GO:2000320 8.96 IL4 IL2
9 positive regulation of isotype switching to IgG isotypes GO:0048304 8.62 IL4 IL2

Molecular functions related to 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 IL4 IL2
2 growth factor activity GO:0008083 8.62 IL4 IL2

Sources for 1-Chloro-2,4-Dinitrobenzene Allergic Contact Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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