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MCID: 47X002
MIFTS: 49

47,xyy

Categories: Fetal diseases, Rare diseases
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs
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Aliases & Classifications for 47,xyy

About this section

MalaCards integrated aliases for 47,xyy:

Name: 47,xyy 74
Xyy Syndrome 74 52 25 58
Double Y Syndrome 52 58 29
47,xyy Syndrome 52 25 58
47, Xyy Syndrome 52 71
Xyy Karyotype 52 25
Yy Syndrome 52 25
Y Disomy 52 58
Camptodactyly-Arthropathy-Coxa Vara-Pericarditis Syndrome 71
Jacob's Syndrome 25
Jacobs Syndrome 52
Disomy Y 52
Double Y 52

Characteristics:

Orphanet epidemiological data:

58
47,xyy syndrome
Inheritance: Not applicable; Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Developmental anomalies during embryogenesis


Sources

Summaries for 47,xyy

About this section
Genetics Home Reference : 25 47,XYY syndrome is characterized by an extra copy of the Y chromosome in each of a male's cells. Although many males with this condition are taller than average, the chromosomal change sometimes causes no unusual physical features. Most males with 47,XYY syndrome have normal production of the male sex hormone testosterone and normal sexual development, and they are usually able to father children. 47,XYY syndrome is associated with an increased risk of learning disabilities and delayed development of speech and language skills. Affected boys can have delayed development of motor skills (such as sitting and walking) or weak muscle tone (hypotonia). Other signs and symptoms of this condition include hand tremors or other involuntary movements (motor tics), seizures, and asthma. Males with 47,XYY syndrome have an increased risk of behavioral, social, and emotional difficulties compared with their unaffected peers. These problems include attention-deficit/hyperactivity disorder (ADHD); depression; anxiety; and autism spectrum disorder, which is a group of developmental conditions that affect communication and social interaction. Physical features related to 47,XYY syndrome can include increased belly fat, a large head (macrocephaly), unusually large teeth (macrodontia), flat feet (pes planus), fifth fingers that curve inward (clinodactyly), widely spaced eyes (ocular hypertelorism), and abnormal side-to-side curvature of the spine (scoliosis). These characteristics vary widely among affected boys and men.

MalaCards based summary : 47,xyy, also known as xyy syndrome, is related to turner syndrome and camptodactyly-arthropathy-coxa vara-pericarditis syndrome. An important gene associated with 47,xyy is IGFBP3 (Insulin Like Growth Factor Binding Protein 3). The drugs Metformin and Entecavir have been mentioned in the context of this disorder. Affiliated tissues include breast, testes and lung, and related phenotypes are delayed speech and language development and low-set ears

NIH Rare Diseases : 52 47, XYY syndrome is a syndrome (group of signs and symptoms) that affects males. For some males with this syndrome, signs and symptoms are barely noticeable. For others, signs and symptoms may include learning disabilities , speech delay , low muscle tone (hypotonia ), and being taller than expected. 47, XYY syndrome is caused by having an extra copy of the Y chromosome in every cell of the body. The syndrome is usually not inherited . Diagnosis can be made based on prenatal tests, or it may occur during childhood or adulthood if a male has signs or symptoms of the disease. Management may include special education as well as intervention or therapies for developmental delays .

Wikipedia : 74 XYY syndrome is a genetic condition in which a male has an extra Y chromosome. There are usually few... more...

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Related Diseases for 47,xyy

About this section

Diseases related to 47,xyy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 turner syndrome 28.8 SRY IGFBP3
2 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 11.6
3 creutzfeldt-jakob disease 11.2
4 azoospermia 10.4
5 infertility 10.4
6 tooth size 10.3
7 autism spectrum disorder 10.2
8 hypogonadotropic hypogonadism 10.2
9 male infertility 10.2
10 hypogonadism 10.2
11 hypotonia 10.2
12 tremor 10.2
13 hair whorl 10.1
14 attention deficit-hyperactivity disorder 10.1
15 hypertelorism 10.1
16 down syndrome 10.1
17 autism 10.1
18 cryptorchidism, unilateral or bilateral 10.1
19 oligospermia 10.1
20 gonadal dysgenesis 10.1
21 learning disability 10.1
22 coloboma of macula 10.0
23 microcephaly 10.0
24 synostosis 10.0
25 radioulnar synostosis 10.0
26 lipoid congenital adrenal hyperplasia 10.0
27 constricting bands, congenital 10.0
28 brachydactyly 10.0
29 oligohydramnios 10.0
30 agammaglobulinemia 10.0
31 tic disorder 10.0
32 olfactory neuroblastoma 10.0
33 neuroblastoma 10.0
34 pulmonary embolism 10.0
35 neurofibromatosis, type ii 10.0
36 elastosis perforans serpiginosa 10.0
37 nondisjunction 10.0
38 noonan syndrome 1 10.0
39 schizophrenia 10.0
40 chromosome 2q35 duplication syndrome 10.0
41 syndactyly, type iii 10.0
42 hydrops fetalis, nonimmune 10.0
43 hypogonadism, male 10.0
44 taurodontism 10.0
45 testes, rudimentary 10.0
46 46,xx sex reversal 1 10.0
47 pituitary adenoma, prolactin-secreting 10.0
48 leukemia, acute myeloid 10.0
49 joint laxity, short stature, and myopia 10.0
50 pervasive developmental disorder 10.0

Graphical network of the top 20 diseases related to 47,xyy:



Diseases related to 47,xyy
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Symptoms & Phenotypes for 47,xyy

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Human phenotypes related to 47,xyy:

58 31 (show all 35)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 delayed speech and language development 58 31 hallmark (90%) Very frequent (99-80%) HP:0000750
2 low-set ears 58 31 hallmark (90%) Very frequent (99-80%) HP:0000369
3 motor delay 58 31 hallmark (90%) Very frequent (99-80%) HP:0001270
4 malar flattening 58 31 hallmark (90%) Very frequent (99-80%) HP:0000272
5 tall stature 58 31 hallmark (90%) Very frequent (99-80%) HP:0000098
6 intellectual disability 58 31 frequent (33%) Frequent (79-30%) HP:0001249
7 hypertelorism 58 31 frequent (33%) Frequent (79-30%) HP:0000316
8 macrocephaly 58 31 frequent (33%) Frequent (79-30%) HP:0000256
9 neonatal hypotonia 58 31 frequent (33%) Frequent (79-30%) HP:0001319
10 attention deficit hyperactivity disorder 58 31 frequent (33%) Frequent (79-30%) HP:0007018
11 specific learning disability 58 31 frequent (33%) Frequent (79-30%) HP:0001328
12 asthma 58 31 frequent (33%) Frequent (79-30%) HP:0002099
13 impulsivity 58 31 frequent (33%) Frequent (79-30%) HP:0100710
14 finger clinodactyly 58 31 frequent (33%) Frequent (79-30%) HP:0040019
15 congenital stationary night blindness 58 31 frequent (33%) Frequent (79-30%) HP:0007642
16 impaired social interactions 58 31 frequent (33%) Frequent (79-30%) HP:0000735
17 macroorchidism 58 31 occasional (7.5%) Occasional (29-5%) HP:0000053
18 hydrocephalus 58 31 occasional (7.5%) Occasional (29-5%) HP:0000238
19 cryptorchidism 58 31 occasional (7.5%) Occasional (29-5%) HP:0000028
20 increased circulating gonadotropin level 58 31 occasional (7.5%) Occasional (29-5%) HP:0000837
21 micropenis 58 31 occasional (7.5%) Occasional (29-5%) HP:0000054
22 azoospermia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000027
23 hypospadias 58 31 occasional (7.5%) Occasional (29-5%) HP:0000047
24 male infertility 58 31 occasional (7.5%) Occasional (29-5%) HP:0003251
25 oligospermia 58 31 occasional (7.5%) Occasional (29-5%) HP:0000798
26 abnormality of brainstem morphology 58 31 occasional (7.5%) Occasional (29-5%) HP:0002363
27 dysgenesis of the cerebellar vermis 58 31 occasional (7.5%) Occasional (29-5%) HP:0002195
28 increased serum testosterone level 58 31 occasional (7.5%) Occasional (29-5%) HP:0030088
29 varicocele 58 31 occasional (7.5%) Occasional (29-5%) HP:0012871
30 cerebellar dysplasia 58 31 occasional (7.5%) Occasional (29-5%) HP:0007033
31 seizure 31 occasional (7.5%) HP:0001250
32 behavioral abnormality 58 Frequent (79-30%)
33 seizures 58 Occasional (29-5%)
34 autistic behavior 58 Occasional (29-5%)
35 hyperactivity 58 Frequent (79-30%)

GenomeRNAi Phenotypes related to 47,xyy according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 8.62 IGFBP3 SRY
Sources

Drugs & Therapeutics for 47,xyy

About this section

Drugs for 47,xyy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 786)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Metformin Approved Phase 4 657-24-9 14219 4091
2
Entecavir Approved, Investigational Phase 4 142217-69-4 153941
3
Bivalirudin Approved, Investigational Phase 4 128270-60-0 16129704
4
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
5
Tranexamic Acid Approved Phase 4 1197-18-8 5526
6
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
7
Ertapenem Approved, Investigational Phase 4 153832-46-3 150610
8
Mepivacaine Approved, Vet_approved Phase 4 96-88-8 4062
9
Tetracaine Approved, Vet_approved Phase 4 94-24-6 5411
10
Glimepiride Approved Phase 4 93479-97-1 3476
11
Gliclazide Approved Phase 4 21187-98-4 3475
12
Glyburide Approved Phase 4 10238-21-8 3488
13
Ciclesonide Approved, Investigational Phase 4 141845-82-1, 126544-47-6 444033
14
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
15
Insulin glargine Approved Phase 4 160337-95-1
16
Tinidazole Approved, Investigational Phase 4 19387-91-8 5479
17
Rabeprazole Approved, Investigational Phase 4 117976-89-3 5029
18
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
19
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
20
Lixisenatide Approved Phase 4 320367-13-3
21
Abciximab Approved Phase 4 143653-53-6
22
Risperidone Approved, Investigational Phase 4 106266-06-2 5073
23
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
24
Haloperidol Approved Phase 4 52-86-8 3559
25
Methylphenidate Approved, Investigational Phase 4 113-45-1 4158
26
Morphine Approved, Investigational Phase 4 57-27-2 5288826
27
Ribavirin Approved Phase 4 36791-04-5 37542
28
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
29
Nystatin Approved, Vet_approved Phase 4 1400-61-9 11953884
30
Efavirenz Approved, Investigational Phase 4 154598-52-4 64139
31
Remifentanil Approved Phase 4 132875-61-7 60815
32
Propofol Approved, Investigational, Vet_approved Phase 4 2078-54-8 4943
33
Peginterferon alfa-2a Approved, Investigational Phase 4 198153-51-4 5360545
34
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
35
Phenylephrine Approved Phase 4 59-42-7 6041
36
Oxymetazoline Approved, Investigational Phase 4 1491-59-4 4636
37
Adenosine Approved, Investigational Phase 4 58-61-7 60961
38
Atropine Approved, Vet_approved Phase 4 51-55-8, 5908-99-6 174174
39
Epinephrine Approved, Vet_approved Phase 4 51-43-4 5816
40
Racepinephrine Approved Phase 4 329-65-7 838
41
Travoprost Approved Phase 4 157283-68-6 5282226
42
Latanoprost Approved, Investigational Phase 4 130209-82-4 5311221 5282380
43
Dorzolamide Approved Phase 4 120279-96-1 5284549 3154
44
Brinzolamide Approved Phase 4 138890-62-7 68844
45
Timolol Approved Phase 4 26839-75-8 5478 33624
46
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
47
Norepinephrine Approved Phase 4 51-41-2 439260
48
Pseudoephedrine Approved Phase 4 90-82-4 7028
49
Ephedrine Approved Phase 4 299-42-3 9294
50
Histamine Approved, Investigational Phase 4 51-45-6 774

Interventional clinical trials:

(show top 50) (show all 1114)
# Name Status NCT ID Phase Drugs
1 Clinical Trial Program of a Medical Instrument Product Unknown status NCT01157455 Phase 4 Aspirin;Clopidogrel;Heparin or Bivalirudin
2 Phase IV Study of the Efficacy of Entecavir in Patients With Chronic Hepatitis B Virus Infection and Persistently Normal Alanine Aminotransferase Unknown status NCT01833611 Phase 4 Entecavir;placebo
3 Cross-reactivity and Tolerability of Ertapenem in Patients With IgE-mediated Allergy to Beta-lactams Unknown status NCT01159379 Phase 4 ertapenem
4 Minimization of Bleeding Complications Through Utilization of Perioperative Tranexamic Acid in Breast Surgery: A Randomized Double-blinded Placebo-controlled Trial Unknown status NCT02615366 Phase 4 Tranexamic Acid;Placebo
5 A PROSPECTIVE, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF THE SUPPLEMENTATION WITH KIOLIC® IN PATIENTS WITH DIAGNOSIS OF METABOLIC SYNDROME TO IMPROVE ENDOTHELIAL FUNCTION AND INFLAMMATORY STATE. "KYMES" Unknown status NCT01168700 Phase 4 aged garlic extract;Placebo
6 Pulpal Blood Flow With the Use of Intra-nasal Anesthetic: a Randomized Double-blind Crossover Study Unknown status NCT03368391 Phase 4 tetracaine HCl and oxymetazoline HCL;2% Lidocaine with 1:100,000 epinephrine;3% Mepivacaine with 1:100,000 epinephrine;saline intranasal;saline infiltration
7 Effects on Incidence of Cardiovascular Events of the Addition of Pioglitazone as Compared With a Sulphonylurea in Type 2 Diabetic Patients Inadequately Controlled With Metformin. Unknown status NCT00700856 Phase 4 add-on pioglitazone;add-on sulphonylurea
8 Phase 4 Cost-effectiveness Study of Beclomethasone Versus Ciclesonide as Controller Medications in Pediatric Asthma in a Hospital in Bogotá Completed NCT01333800 Phase 4 Beclomethasone;Ciclesonide
9 Vitamin D Increases Serum Levels of the Soluble Receptor for Advanced Glycation End Products in Women With PCOS Completed NCT03644212 Phase 4 Vitamin D3
10 A Phase IV Open, Randomized, Controlled Study to Evaluate the Safety and Immunogenicity of a Pediatric Presentation (0.25 ml) of the Virosomal Hepatitis A Virus (HAV) Vaccine HAVpur in Healthy Young Children Aged Between and Including 18 Months to 47 Months, Using a 0/6 Month Immunization Schedule Completed NCT01349829 Phase 4
11 Body Composition in Infants With Klinefelter Syndrome and Effects of Testosterone Treatment Completed NCT02408445 Phase 4 testosterone cypionate 200mg/ml
12 Modified Non-clarithromycin Triple Therapy in Eradicating Helicobacter Pylori Completed NCT02776371 Phase 4 Modified non-clarithromycin triple therapy;Sequential therapy
13 Study of the Effect of Calcifediol Supplementation on Left Ventricular Function in Cardiopathic Patients Undergoing Major Orthopedic Surgery. Completed NCT03403933 Phase 4 Didrogyl
14 A Randomized, Multicenter, Open-Label, Parallel-Group, 28 Days Phase IV Study Comparing The Postprandial Plasma Glucose Profile of Lixisenatide With That of Sitagliptin Add-On to Insulin Glargine in Type 2 Diabetes Mellitus Completed NCT02200991 Phase 4 LIXISENATIDE AVE0010;Sitagliptin;Insulin glargine HOE901
15 Anti-inflammatory Effects of Intracoronary and Intravenous Abciximab Administration During Primary Percutaneous Coronary Intervention.(Molecole di Adesione Nella Sindrome Coronarica Acuta Completed NCT01757457 Phase 4 Intracoronary administration of an abciximab bolus during primary PCI;Intravenous administration of an abciximab bolus during primary PCI
16 Efficacy and Safety of Risperidone Oral Solution Combination Clonazepam Versus Haloperidol IM Injection for Treatment of Acute Psychotic Agitation in Schizophrenia Completed NCT00859872 Phase 4 risperidone oral solution;haloperidol
17 Reveal® XT Performance Trial Completed NCT00680927 Phase 4
18 Respiratory Muscle Stretching in Patients With Chronic Obstructive Pulmonary Disease Submitted a Pulmonary Rehabilitation Program Completed NCT00935181 Phase 4
19 A Feasibility Study: Understanding and Altering Pain Expectations in Subjects With Osteoarthritis of the Knee or Hip Completed NCT02155257 Phase 4 Modafinil;Gabapentin;Placebo
20 Oral Nystatin Prophylaxis to Prevent Systemic Fungal Infection in Very Low Birth Weight Preterm Infants: a Randomized Controlled Trial Completed NCT03390374 Phase 4 Nystatin Oral
21 The Effect of Prior Short Course Combination Antiretroviral Therapy Administered for the Prevention of Mother-to-Child Transmission (pMTCT) of HIV-1 on Subsequent Treatment Efficacy in Treatment-"Nearly Naive" Participants Completed NCT00442962 Phase 4 Efavirenz;Emtricitabine/Tenofovir disoproxil fumarate
22 Target-controlled Infusion of Propofol and Remifentanil During General Anaesthesia Guided by Entropy of the Electroencephalogram: Comparison Between Manual Perfusion and Automated Perfusion Completed NCT00391885 Phase 4
23 Chronic Obstructive Pulmonary Disease and Weaning From Mechanical Ventilation in Difficult to Wean Patients; Randomized Prospective Study Completed NCT00355732 Phase 4
24 A New Strategy Regarding Discontinuation of Dual Antiplatelet; Real Safety and Efficacy of a 3-month Dual Antiplatelet Therapy Following Zotarolimus-eluting Stents Implantation (RESET Trial) Completed NCT01145079 Phase 4
25 Prospective Randomized Trial to Evaluate the Efficacy of Donor Preconditioning With Dopamine on Initial Graft Function After Kidney Transplantation Completed NCT00115115 Phase 4 Dopamine infusion to brain dead organ donors
26 Prospective, Randomized Clinical Trial,to Compare Standard Trabeculectomy to the Ex-PRESS Mini Glaucoma Shunt Implantation Under a Scleral Flap in Eyes With Open-Angle Glaucoma Completed NCT00698438 Phase 4
27 The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment Completed NCT03121521 Phase 4 Melatonin 10 mg;Placebo
28 ADenosine Following Pulmonary Vein Isolation to Target Dormant Conduction Elimination: the ADVICE Trial Completed NCT01058980 Phase 4
29 A Randomized Trial Comparing Daily Atropine Versus Weekend Atropine Completed NCT00094614 Phase 4 Atropine
30 Choroidal Thickness and Its Correlations With Ocular Parameters in Cases With Primary Open-angle Glaucoma Completed NCT03966560 Phase 4 Brimonidine Tartrate;Dorzolamide (as Dorzolamide Hydrochloride) 20 Mg/mL and Timolol (as Timolol Maleate) 5 Mg/mL Eye Drops;Brinzolamide/Timolol 10 MG/1 ML-5 MG/1 ML Ophthalmic Suspension;Travoprost and Timolol;Bimatoprost and Timolol;Latanoprost
31 Comparison of the Effect of Fluoride Remineralizer Gel and Foam: a Randomized Clinical Trial Completed NCT02490592 Phase 4
32 Effect of Aspirin Intake on Awakening Versus at Bedtime on Circadian Rhythm of Platelet Reactivity in Healthy Subjects Completed NCT01900639 Phase 4
33 Crystalloid Coload Combined With Variable Rate Phenylephrine Infusion for Prevention of Hypotension During Spinal Anesthesia for Elective Cesarean Delivery vs Crystalloid Coload Alone Completed NCT01378325 Phase 4 Phenylephrine;saline
34 A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group Study Evaluating the Pharmacodynamic Effect of a 6-week Treatment With Triamcinolone Acetonide Aqueous Nasal Spray 110 μg and 220 μg Once Daily on Basal Hypothalamic-Pituitary-Adrenal (HPA) Axis Function in Children [>=2 to < 12 Years of Age] With Allergic Rhinitis (AR). Completed NCT01154153 Phase 4 Placebo nasal spray;Triamcinolone acetonide aqueous (TAA-AQ) nasal spray (NASACORT AQ);Placebo nasal spray;Claritin® Syrup
35 Clinical Evaluation of Day and Night Skin Care Creams Supplemented With MediCell Technology (MCT)'s Composition of Defensins and Supportive Molecules Completed NCT02765763 Phase 4 2-Minute Reveal Masque;24/7 Barrier Repair Cream;8-in-1 BioSerum;Null Formula 2-Minute Reveal Masque;Null Formula 24/7 Barrier Repair Cream;Null Formula 8-in-1 BioSerum
36 Effects of Nitroglycerin Versus Labetalol on Tissue Perfusion During Deliberate Hypotension for Sinus Endoscopic Surgery. Completed NCT03809065 Phase 4 Nitroglycerin;Labetalol
37 Patient-controlled Intermittent Epidural Bolus Versus Epidural Infusion for Posterior Spinal Fusion After Adolescent Idiopathic Scoliosis Completed NCT02669004 Phase 4 Intermittent bolus epidural morphine;continuous epidural morphine
38 Impact of Dexmedetomidine on the Incidence of Postoperative Delirium in Patients After Cardiac Surgery: a Randomized, Double-blinded, and Placebo-controlled Clinical Trial Completed NCT02267538 Phase 4 dexmedetomidine hydrochloride for injection;0.9% sodium chloride for injection
39 Nasally Inhaled Isopropyl Alcohol Versus Oral Ondansetron for the Treatment of Nausea in the Emergency Department: A Double-Blind Randomized Controlled Trial Completed NCT02760069 Phase 4 Inhaled isopropyl alcohol;Oral ondansetron;Inhaled normal saline;Oral placebo
40 Prospective, Randomized Clinical Trial of a Silver Eluting Dressing System for Prevention of Lower Extremity Revascularization Wound Complications Completed NCT01229358 Phase 4
41 Effects of Anemia Correction on Vascular Function, Endothelial Cell Markers and Monocyte Apoptosis in Renal Transplant Recipients Completed NCT00204334 Phase 4 darbopoeitin
42 Incontinence & Intimate Partners: Assessing the Contribution of Treatment Completed NCT01559389 Phase 4 Solifenacin
43 Effectiveness and Safety of Inactivated EV71 Vaccine (Human Diploid Cell) in 6-71 Months Children: an Open-label Controlled Phase â…£ Clinical Study Completed NCT03001986 Phase 4
44 Randomized Trial of 24 or 48 Weeks of Peginterferon Alfa-2a Plus Ribavirin for Chronic Hepatitis C Virus Genotype 1-infected Patients in Taiwan Completed NCT00495131 Phase 4 Pegylated interferon alfa-2a plus ribavirin;Pegylated interferon alfa-2a plus ribavirin
45 Study of Methylphenidate to Treat Gait Disorders And Attention Deficit In Parkinson's Disease: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Multicentric Trial Completed NCT00914095 Phase 4 methylphenidate;placebo
46 Effects of Eplerenone on Left Ventricular Hypertrophy in Patients With Resistant Hypertension and Obstructive Sleep Apnoea Completed NCT03186742 Phase 4 Eplerenone 50 mg Tab
47 Nicotine Replacement Therapy Added to Cognitive Behavioral Therapy for Smoking Cessation in Patients With Major Mental Illness Completed NCT00320723 Phase 4 bupropion, transdermal nicotine patch
48 Midazolam With Meperidine and Dexmedetomidine vs Midazolam With Meperidine for Sedation During ERCP Completed NCT01404689 Phase 4 Dexmedetomidine
49 Pneumococcal Conjugate Vaccine (PCV) Schedules for the Northern Territory (NT): Randomised Controlled Trial of Booster Vaccines to Broaden and Strengthen Protection From Invasive and Mucosal Infections. Completed NCT01735084 Phase 4
50 Phase 4 Study of Primary Use of the Vacuum Assisted Laparostomy in Treatment of Severe Peritonitis Completed NCT01531543 Phase 4

Search NIH Clinical Center for 47,xyy

Sources

Genetic Tests for 47,xyy

About this section

Genetic tests related to 47,xyy:

# Genetic test Affiliating Genes
1 Double Y Syndrome 29
Sources

Anatomical Context for 47,xyy

About this section

MalaCards organs/tissues related to 47,xyy:

40
Breast, Testes, Lung, Liver, Bone, Heart, Brain
Sources

Publications for 47,xyy

About this section

Articles related to 47,xyy:

(show top 50) (show all 30000)
# Title Authors PMID Year
1
Clinical aspects of infertile 47,XYY patients: a retrospective study. 61 52
28715980 2019
2
Oral, physical, and behavioral aspects of patient with chromosome 47, XYY syndrome. 61 52
26381641 2015
3
Positive effects of early androgen therapy on the behavioral phenotype of boys with 47,XXY. 61 52
25939399 2015
4
Coagulation monitoring and transfusion in major non-emergency orthopaedic surgery - An observational study. 61
32280164 2020
5
Clinical Analysis of Magnetic Nanoparticle Contrast Agent in the Diagnosis of Occult Fracture by Multislice Spiral CT and MRI. 61
32385015 2020
6
The convenient use of fluorescamine for spectrofluorimetric quantitation of pramipexole in pure form and pharmaceutical formulation; application to content uniformity testing. 61
32413715 2020
7
A Vertical Measurement System to Predict the Change in Leg Length in Total Hip Arthroplasty. 61
32514423 2020
8
Immune stimulation effect of PBDEs via prostaglandin pathway in pantropical spotted dolphin: An in vitro study. 61
32339795 2020
9
Predictors of clavicle fixation in multiply injured patients. 61
32071531 2020
10
Metabolomic insights into the lasting impacts of early-life exposure to BDE-47 in mice. 61
32283404 2020
11
Reply to Technical Details and Results of a Minimally Invasive Management of Gastric Band Erosions: a Series of 47 Patients. 61
32328878 2020
12
Impact of passive sampler protection apparatus on sediment porewater profiles of hydrophobic organic compounds. 61
32224359 2020
13
Debromination of polybrominated diphenyl ethers (PBDEs) by palladized zerovalent zinc particles: Influence factors, pathways and mechanism. 61
32302906 2020
14
Clinical case of successful treatment of internal carotid artery dissection during aneurysm embolization in acute period of subarachnoid hemorrhage. 61
32547674 2020
15
Effects of polymer aging on sorption of 2,2',4,4'-tetrabromodiphenyl ether by polystyrene microplastics. 61
32289606 2020
16
Hypoxia responsiveness linked variant in EGLN1 gene is enriched in oral cancer patients. 61
32464411 2020
17
Outcomes from a Male-to-Male Promotores Intervention in an Emerging Latino Community. 61
31617052 2020
18
Macrolide resistant Mycobacterium avium complex pulmonary disease following clarithromycin and ethambutol combination therapy. 61
32442113 2020
19
Tattoo pigment mimicking axillary lymph node calcifications on mammography. 61
32550957 2020
20
ROS-mediated programmed cell death (PCD) of Thalassiosira pseudonana under the stress of BDE-47. 61
32179226 2020
21
Minimizing contrast media dose in CT pulmonary angiography with high-pitch technique. 61
32436788 2020
22
Isotopic fractionation during acid digestion of calcite: A combined ab initio quantum chemical simulation and experimental study. 61
32207173 2020
23
Understanding the role of bacterial cellular adsorption, accumulation and bioavailability regulation by biosurfactant in affecting biodegradation efficacy of polybrominated diphenyl ethers. 61
32114132 2020
24
Encephalomyeloneuritis and arthritis after treatment with immune checkpoint inhibitors. 61
32461353 2020
25
Prevalence of virulence and antimicrobial resistance genes in Aeromonas species isolated from marketed cockles (Tegillarca granosa) in Korea. 61
31943254 2020
26
Effects of oxygen plasma ashing treatment on carbonate clumped isotopes. 61
32246871 2020
27
Longitudinal Development of Receptive Vocabulary in Children with Cerebral Palsy and Anarthria: Use of the MacArthur-Bates CDI. 61
31352864 2020
28
Paravertebral block for radiologically inserted gastrostomy tube placement in amyotrophic lateral sclerosis. 61
32297335 2020
29
Paraneoplastic tumefactive demyelination in a 47-year-old man with underlying seminoma. 61
32217464 2020
30
MR imaging findings of calcinosis cutis in primary Sjogren syndrome, a rare manifestation. 61
32435323 2020
31
Natural Horse Boarding Vs Traditional Stable: A Comparison of Hormonal, Hematological and Immunological Parameters. 61
32441218 2020
32
Compensating for climate change-induced cue-environment mismatches: evidence for contemporary evolution of a photoperiodic reaction norm in Colias butterflies. 61
32333476 2020
33
Fatigue, Participation and Quality of Life in Adolescents and Young Adults with Acquired Brain Injury in an Outpatient Rehabilitation Cohort. 61
31746261 2020
34
Cellulose nanofibrils and silver nanowires active coatings for the development of antibacterial packaging surfaces. 61
32475576 2020
35
Biochemical Characterization of VapC46 Toxin from Mycobacterium tuberculosis. 61
32236842 2020
36
An integrated biorefinery process for adding values to corncob in co-production of xylooligosaccharides and glucose starting from pretreatment with gluconic acid. 61
32222689 2020
37
Distinguishing coagulase-negative Staphylococcus bacteremia from contamination using blood-culture positive bottle detection pattern and time to positivity. 61
32131983 2020
38
The "Key" or "Critical" Portions of an Operation: Understanding Attending Supervision and Resident Autonomy From a Legal Perspective. 61
32173294 2020
39
The preparation and evaluation of core-shell magnetic dummy-template molecularly imprinted polymers for preliminary recognition of the low-mass polybrominated diphenyl ethers from aqueous solutions. 61
32247120 2020
40
Alemtuzumab and prescription medication use in the MS population. 61
32403069 2020
41
Effects of heat conduction of implant surface at thermal stimulation on implant placement. 61
31974727 2020
42
Isolated Diaphragmatic Metastasis Originating From Early Endometrial Cancer. 61
31978375 2020
43
Synchronous Pulmonary Adenocarcinomas. 61
32146481 2020
44
High prevalence of cardiometabolic risk features in adolescents with 47,XXY/Klinefelter syndrome. 61
32542985 2020
45
Altered pain modulation to Noxious Heat Thermal Stimuli in Burning Mouth Syndrome. 61
32531814 2020
46
Prophylactic internal iliac artery ligation versus balloon occlusion for placenta accreta spectrum disorders: A retrospective cohort study. 61
32506473 2020
47
Combination of electromagnetic navigation bronchoscopy-guided microwave ablation and thoracoscopic resection: An alternative for treatment of multiple pulmonary nodules. 61
32286013 2020
48
Recurrent antibody-mediated rejection in renal allograft: physician's dilemma. 61
32557204 2020
49
Accuracy of freely available online GFR calculators using the CKD-EPI equation. 61
32562002 2020
50
Kinase inhibitor roscovitine as a PB2 cap-binding inhibitor against influenza a virus replication. 61
32327257 2020
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Variations for 47,xyy

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Expression for 47,xyy

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Search GEO for disease gene expression data for 47,xyy.
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Pathways for 47,xyy

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GO Terms for 47,xyy

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Sources for 47,xyy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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