48,xyyy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: 48X005 MIFTS: 39	48,xyyy Categories: Fetal diseases, Neuronal diseases, Rare diseases, Reproductive diseases
Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for 48,xyyy

MalaCards integrated aliases for 48,xyyy:

Name: 48,xyyy ⁵²

48,xyyy Syndrome ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Fetal diseases
Anatomical: Neuronal diseases Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Congenital malformations, deformations and chromosomal abnormalities

Chromosomal abnormalities, not elsewhere classified

Other sex chromosome abnormalities, male phenotype, not elsewhere classified

Other specified sex chromosome abnormalities, male phenotype

Orphanet: ⁵⁸

Rare neurological diseases

Rare infertility disorders

Developmental anomalies during embryogenesis

External Ids:

ICD10 via Orphanet ³³ Q98.8

Orphanet ⁵⁸ ORPHA99329

Sources

Summaries for 48,xyyy

NIH Rare Diseases : ⁵² The following summary is from Orphanet , a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 99329 Definition A rare Y chromosome number anomaly that affects only males and is characterized by mild-moderate developmental delay (especially speech), normal to mild intellectual disability , large, irregular teeth with poor enamel, tall stature and acne. Radioulnar synostosis and clinodactyly have also been associated. Boys generally present normal genitalia, while hypogonadism and infertility is frequently reported in adult males. Visit the Orphanet disease page for more resources.

MalaCards based summary : 48,xyyy, also known as 48,xyyy syndrome, is related to radioulnar synostosis, nonsyndromic and hypogonadotropic hypogonadism. The drugs Bazedoxifene and Nalbuphine have been mentioned in the context of this disorder. Affiliated tissues include testes, liver and lung, and related phenotypes are global developmental delay and depressed nasal bridge

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Related Diseases for 48,xyyy

Diseases related to 48,xyyy via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	radioulnar synostosis, nonsyndromic	10.2
2	hypogonadotropic hypogonadism	10.2

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Symptoms & Phenotypes for 48,xyyy

Human phenotypes related to 48,xyyy:

⁵⁸ ³¹ (show all 31)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	global developmental delay ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001263
2	depressed nasal bridge ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0005280
3	hypertelorism ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000316
4	short neck ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000470
5	delayed speech and language development ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000750
6	pes planus ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001763
7	intellectual disability, mild ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001256
8	feeding difficulties ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0011968
9	thick lower lip vermilion ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000179
10	recurrent upper respiratory tract infections ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002788
11	acne ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0001061
12	high palate ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000218
13	abnormal dermatoglyphics ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0007477
14	epicanthus ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000286
15	azoospermia ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000027
16	long philtrum ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000343
17	asthma ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002099
18	radioulnar synostosis ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0002974
19	tall stature ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000098
20	dislocated radial head ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0003083
21	aggressive behavior ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000718
22	abnormal renal morphology ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0012210
23	low frustration tolerance ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000744
24	male hypogonadism ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0000026
25	impulsivity ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0100710
26	primary gonadal insufficiency ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0008193
27	hypoplasia of dental enamel ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0006297
28	irregularly spaced teeth ⁵⁸ ³¹	hallmark (90%)	Very frequent (99-80%)	HP:0006316
29	intellectual disability ⁵⁸		Very frequent (99-80%)
30	behavioral abnormality ⁵⁸		Very frequent (99-80%)
31	abnormality of the foot ⁵⁸		Very frequent (99-80%)

Sources

Drugs & Therapeutics for 48,xyyy

Drugs for 48,xyyy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1608)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bazedoxifene

Approved, Investigational

Phase 4

198481-32-2

Nalbuphine

Approved

Phase 4

20594-83-6

5311304 5360630

Amantadine

Approved

Phase 4

768-94-5

2130

Propafenone

Approved

Phase 4

54063-53-5

4932

Meropenem

Approved, Investigational

Phase 4

96036-03-2, 119478-56-7

441130 64778

Acarbose

Approved, Investigational

Phase 4

56180-94-0

441184

Nepafenac

Approved, Investigational

Phase 4

78281-72-8

151075

Riociguat

Approved

Phase 4

625115-55-1

Fluvoxamine

Approved, Investigational

Phase 4

54739-18-3

3404 5324346

Lincomycin

Approved, Vet_approved

Phase 4

154-21-2

656509

Fenoldopam

Approved

Phase 4

67227-57-0, 67227-56-9

3341

Eleuthero

Approved, Experimental

Phase 4

Hexetidine

Approved, Investigational

Phase 4

141-94-6

Eszopiclone

Approved, Investigational

Phase 4

138729-47-2

969472

Bosentan

Approved, Investigational

Phase 4

147536-97-8

104865

Cobicistat

Approved

Phase 4

1004316-88-4

Everolimus

Approved

Phase 4

159351-69-6

70789204 6442177

Donepezil

Approved

Phase 4

120014-06-4

3152

Nifedipine

Approved

Phase 4

21829-25-4

4485

Stavudine

Approved, Investigational

Phase 4

3056-17-5

18283

Zidovudine

Approved

Phase 4

30516-87-1

35370

Tramadol

Approved, Investigational

Phase 4

27203-92-5

33741

Flurbiprofen

Approved, Investigational

Phase 4

5104-49-4

3394

Saw palmetto

Approved, Experimental, Investigational

Phase 4

Neomycin

Approved, Vet_approved

Phase 4

1404-04-2

8378

Eplerenone

Approved

Phase 4

107724-20-9

150310 443872

carbamide peroxide

Approved

Phase 4

124-43-6

Metformin

Approved

Phase 4

657-24-9

14219 4091

Hydrocortisone

Approved, Vet_approved

Phase 4

50-23-7

5754

Hydrocortisone acetate

Approved, Vet_approved

Phase 4

50-03-3

Saquinavir

Approved, Investigational

Phase 4

127779-20-8

60787

Pamidronate

Approved

Phase 4

40391-99-9

4674

Omalizumab

Approved, Investigational

Phase 4

242138-07-4

Mycophenolic acid

Approved

Phase 4

24280-93-1

446541

Terlipressin

Approved, Investigational

Phase 4

14636-12-5

72081

Norepinephrine

Approved

Phase 4

51-41-2

439260

Interferon beta-1a

Approved, Investigational

Phase 4

145258-61-3

6438354

Natalizumab

Approved, Investigational

Phase 4

189261-10-7

Orphenadrine

Approved

Phase 4

83-98-7

4601

Indinavir

Approved

Phase 4

150378-17-9

5362440

Etonogestrel

Approved, Investigational

Phase 4

54048-10-1

40976 6917715

Dezocine

Approved, Investigational

Phase 4

53648-55-8

40841 3033053

Salmon calcitonin

Approved, Investigational

Phase 4

47931-85-1

16129616

Guaifenesin

Approved, Investigational, Vet_approved

Phase 4

93-14-1

3516

Tavaborole

Approved, Investigational

Phase 4

174671-46-6

Neostigmine

Approved, Vet_approved

Phase 4

59-99-4

4456

Fosamprenavir

Approved

Phase 4

226700-79-4

131536

Nefopam

Approved, Investigational

Phase 4

13669-70-0

Irbesartan

Approved, Investigational

Phase 4

138402-11-6

3749

Atenolol

Approved

Phase 4

29122-68-7

2249

Interventional clinical trials:

(show top 50) (show all 10000)

#	Name	Status	NCT ID	Phase	Drugs
1	A Prospective, Randomized, Multicenter, Open-label Study Evaluating HBeAg Seroconversion in HBeAg Positive CHB Patients on Treatment With NA Switched to Combined Therapy With Peginterferon Alfa-2a and NA for 48 Weeks	Unknown status	NCT02474316	Phase 4	Peginterferon alfa-2a;nucleos(t)ide analgoue
2	Cost-effectiveness of Different Antiretroviral Treatment in Patients HIV Naive. Randomized Clinical, Not Masked, Trial Comparing DRVr3TC, ABC3TC (Kivexa) RPV, or EVG COBI FTC TDF (Stribild) for 48 Weeks	Unknown status	NCT02470650	Phase 4	elvitegravir/cobicistat/emtricitabine/tenofovir;Darunavir;abacavir/lamivudine;Ritonavir;Lamivudine;rilpivirine
3	Emtricitabine for Naive Chinese Pregnant Chronic Hepatitis B Patients	Unknown status	NCT02327702	Phase 4	Emtricitabine
4	Efficacy and Safety of Shenyankangfu Tablets for Primary Glomerulonephritis—a Multicentre, Prospective, Double-blind, Double-dummy, Randomized Controlled Clinical Trial	Unknown status	NCT02063100	Phase 4	Shenyankangfu tablets;Losartan potassium 50mg;Shenyankangfu tablets and Losartan potassium 50mg;Shenyankangfu tablets and Losartan potassium 100mg;Losartan potassium 100mg
5	Effectiveness of Bazedoxifene for Prevention of Glucocorticoid-induced Bone Loss in RA Patients	Unknown status	NCT02602704	Phase 4	Bazedoxifene;Calcium/Vit D
6	A Multi-center, Open Label, Randomized Study of Effects and Safety Between Adefovir Dipivoxil Plus Polyene Phosphatidylcholine Capsule Versus Adefovir Dipivoxil Alone in Chronic Hepatitis B Patients	Unknown status	NCT01436539	Phase 4	Adefovir Dipivoxil and polyene phosphatidylcholine;Adefovir Dipivoxil
7	Eplerenone and Aliskiren Research Targeting Hypertensive Patients With Left Ventricular Hypertrophy	Unknown status	NCT01893788	Phase 4	Aliskiren;Eplerenone
8	The Effect of Ketamine on Production of Inflammatory Markers in Post Operative Patients in Mulago Hospital: A Randomized Clinical Trial	Unknown status	NCT01339065	Phase 4	Ketamine
9	The Efficacy and Safety of the Anti Hepatitis B Placenta Transfer Factor Injection in the Treatment of HBeAg Positive Chronic Hepatitis B, Randomized, Double Blind, Placebo Controlled, Multi Center Clinical Trial	Unknown status	NCT02412319	Phase 4	Anti-HBV placenta transfer factor injection
10	A Phase IV Multicenter Study of the Efficacy and Safety of 48-Week Induction Treatment With TRIZIVIR (Abacavir 300 Mg/Lamivudine 150 Mg/Zidovudine 300 Mg Combination Tablet BID) With Efavirenz (600 Mg QD) Followed by 48-Week Randomized, Open-Label, Maintenance Treatment With TRIZIVIR With or Without Efavirenz in HIV-1 Infected Antiretroviral Therapy Naive Subjects	Unknown status	NCT00011895	Phase 4	Abacavir sulfate, Lamivudine and Zidovudine;Efavirenz
11	Multi-center, Randomized, Open Label, Comparative, Phase IV Study to Evaluate the Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid for 48 Weeks in Advanced IgA Nephropathy	Unknown status	NCT02981212	Phase 4	Mycophenolate Mofetil;ACE inhibitor;Corticosteroid;ARB
12	A Prospective, Randomized, Multicenter, Open-label, Exploratory Study of Utilizing of "Response-Guided-Therapy (RGT)" Strategy on Optimal Nucleoside Analogue (NUC)-Experienced Patients	Unknown status	NCT02560649	Phase 4	Peginterferon alfa-2a plus Entecavir;Peginterferon alfa-2a plus Lamivudine;Peginterferon alfa-2a plus Adefovir;Peginterferon alfa-2a plus Tenofovir;Entecavir;Lamivudine;Adefovir;Tenofovir disoproxil
13	Efficacies of Entecavir Add on Chronic Hepatitis B Patients With HBV DNA Load ≥1000 Copies/ml After 6 Months Treatment of Peginterferon Alpha 2a	Unknown status	NCT02368288	Phase 4	entecavir
14	Efficacies of Entecavir Add on HBeAg Negative Chronic Hepatitis B Patients With HBV DNA Load ≥1000 Copies/ml After 3 Months of Peginterferon Alpha 2a Treatment	Unknown status	NCT02365402	Phase 4	Entecavir
15	Open, Randomized and Multicenter Phase IV Study to Compare the Efficacy and Safety of Two Different Treatments Duration 24 Versus 48 Weeks in Chronic Hepatitis C Genotypes 2 and/or 3 co-Infected HIV-HCV Patients.	Unknown status	NCT00611819	Phase 4	Peg interferon + Ribavirin;Peg interferon + Ribavirin
16	Sedation of Mechanically Ventilated Critically Ill Patients: Midazolam Versus Dexmedetomidine	Unknown status	NCT01256866	Phase 4	Dexmedetomidine;Midazolam
17	Prospective, Double-blinded, Randomised, Placebo Controlled Trial of Pre-emptive Analgesia to Prevent Pain Following Sternotomy for Cardiac Surgery.	Unknown status	NCT01480765	Phase 4	Pregabalin;Ketamine infusion;Placebo capsules;Placebo infusion
18	Prospective Analysis of the Incidence of Ventilator-associated Pneumonia Related to the Humidification System: Heat and Moisture Exchanger Versus Heated Humidification	Unknown status	NCT01546974	Phase 4
19	Transfer From Methadone to Buprenorphine Maintenance Treatment Using Buprenorphine Patches: A Study on Practicability With Patients Maintained With Daily Dosages Between 60mg and 100mg Methadone.	Unknown status	NCT00750217	Phase 4	Buprenorphine patch and sublingual tablets
20	Efficacy and Safety of an Initial Regimen Raltegravir (RAL) + Lamivudine/Abacavir Fixed-Dose Combination (3TC/ABC FDC) for 48 Weeks in ART-naïve, HIV/TB Co-Infected Adult Subjects Receiving Rifabutin-containing, 1-line Anti-TB Therapy	Unknown status	NCT01059422	Phase 4	Raltegravir; Abacavir/Lamivudine
21	A Randomised, Multi-Centre, Open-Label Study in Well-Controlled Treatment-Experienced HIV-Infected Patients to Assess Compliance With a Once-Daily Regimen of Lamivudine, Efavirenz and Didanosine Versus Continuation of Current Anti-Retroviral Regimen Delivered at Least Twice Daily	Unknown status	NCT00214435	Phase 4	once daily minimum 3-drug regimen of anti-retroviral medications
22	A Single Center, Prospective Phase IV, Open-Label, Randomized Trial Comparing the Efficacy , Tolerability, and Safety of Quadritherapy Regimen (Reiferon Retard® + Ribavirin + Nitazoxanide + Alfacalcidol ( Bon-One ®) ) Versus Triple Therapy Regimen (Reiferon Retard® + Ribavirin + Nitazoxanide) Versus the Standard of Care Regimen(Reiferon Retard® + Ribavirin) in the Treatment of Naïve Chronic Hepatitis- C Among the Egyptian Population. Effectiveness Will be Evaluated Based on Sustained Viral Response (SVR)	Unknown status	NCT01896609	Phase 4	Bon one in Arm 3;Xerovirinc in Arm 2;Ribavirin in Arm 1
23	A Randomized Comparison of Two Albumin Administration Schedules for Spontaneous Bacterial Peritonitis	Unknown status	NCT00761098	Phase 4	Standard Care;Experimental
24	A Multicenter, Open-label, Prospective Study to Evaluate Antiviral Efficacy and Safety of Entecavir Plus Tenofovir Combination in Subjects With Multi-drug Resistant Chronic Hepatitis B Virus Infection	Unknown status	NCT01594905	Phase 4	Entecavir + Tenofovir (MDR group)
25	A Randomized, Controlled, Open-label, Multicenter Clinical Trial to Evaluate the Addition of PegIFN Alfa-2a to CHB Patients Treated With Nucleot(s)Ides	Unknown status	NCT02644538	Phase 4	PegIFN alfa-2a
26	Post Operative Pain Control Among Intrathecal 0.1 mg Morphine, Femoral Nerve Block, or Periarticular Infiltration of 20 mL of 0.25% Bupivacaine in Patients Post Intramedullary Hip Screw	Unknown status	NCT01219088	Phase 4	Bupivacaine, morphine
27	Impact of Starting a Dolutegravir-based Regimen on HIV-1 Proviral DNA Reservoir Of Treatment Naïve and Experienced Patients	Unknown status	NCT02370979	Phase 4
28	Chlorhexidine Gluconate for Prevention of Ventilator Associated Pneumonia in a Pediatric Intensive Care Unit.	Unknown status	NCT01883596	Phase 4	0.12% chlorhexidine solution;Placebo
29	A Phase IV, Open Label, Multi-Center, Study of Maintenance Intravitreous Injections of Macugen (Pegaptanib Sodium) Given Every 6 Weeks for 48 Weeks in Subjects With Subfoveal Neovascular Age-Related Macular Degeneration (AMD) Initially Treated With a Modality Resulting in Maculopathy Improvement	Unknown status	NCT00354445	Phase 4	pegaptanib sodium (Macugen)
30	Programmatic Implementation of ACTs in Malawi: Safety and Effectiveness of Combination Therapies With Repeated Treatments for Uncomplicated P. Falciparum Malaria Over a Three-year Period	Unknown status	NCT01038063	Phase 4	Artemether-lumefantrine combination
31	An Open, Single-Arm, Multi-Center, Phase IV Pilot Study of Treatment of Antiretroviral Naive HIV-1 Infected Patients With Tenofovir Disoproxil Fumarate in Combination With Emtricitabine and Zidovudine	Unknown status	NCT00199121	Phase 4	Zidovudine (drug)
32	Efficacy and Safety of a Hansenula-derived Pegylated Interferon α2a (Reiferon Retard®) in Treatment of Patients With Chronic Hepatitis C Virus Infection: A National Multi-center Phase IV Open Label Non-Randomized Trial	Unknown status	NCT01649245	Phase 4	Reiferon retard
33	Postoperative Analgesia After Thoracotomy Without Thoracic Epidural Analgesia: Continuous Wound Catheter Analgesia Associated With Intravenous Morphine Patient-Controlled-Analgesia (PCA)	Unknown status	NCT01698203	Phase 4	ropivacaine 0.75% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun);Placebo;ropivacaine 0.2% - device : wound catheter Silver™ 19 cm and Easypump™ 400 mL (BBraun)
34	Comparison of the Efficacy and Safety of NALDEBAIN With Conventional Treatment After Laparoscopic Cholecystectomy	Unknown status	NCT03713216	Phase 4	Naldebain;Morphine
35	Efficacy and Safety of Abelmoschus Manihot for IgA Nephropathy: a Multicentre, Double-blind, Double-dummy, Randomized Controlled Trial	Unknown status	NCT02231125	Phase 4	Losartan;Abelmoschus manihot
36	Impact of Pretreatment With Omega 3 Enriched Lipid Emulsion on Early Neurological Complications After Living Donor Liver Transplantation. A Randomized Controlled Trial>	Unknown status	NCT02544919	Phase 4	SMOF lipid (SMOFLIPID) pre treatment
37	Multicenter Prospective Trial to Investigate Accuracy of Ultrasound to Predict Relapse After Discontinuation of Infliximab and Efficacy/Safety of Readministration of Infliximab in Patients With Rheumatoid Arthritis in Low Disease Activity	Unknown status	NCT02770794	Phase 4	Infliximab
38	Naproxen for Acute Pain After Surgery: A Randomized, Placebo-Controlled Trial	Unknown status	NCT00615875	Phase 4	naproxen;placebo
39	Placebo Controlled Study Using Lovaza as Treatment for Non-Alcoholic Fatty Liver Disease	Unknown status	NCT00941642	Phase 4	Lovaza;placebo control
40	Neutrophil gElatinase-associated Lipocalin alloWs Intensive treatMent Of cOntrast Induced Nephropathy in Patients With Urgent/Emergency Percutaneous Coronary Intervention	Unknown status	NCT01491243	Phase 4	Intensive treatment with sodium bicarbonate;Standard treatment with saline infusion
41	A Multi Center, Phase IIIb Study to Evaluate the Efficacy of Response Guided Therapy Using Quantitative HBsAg Measurement in Patient With HBeAg Positive Chronic Hepatitis B:	Unknown status	NCT01456312	Phase 4	Peginterferon alfa-2a;Entecavir
42	A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury	Unknown status	NCT02071407	Phase 4	Midazolam;Placebo
43	Analysis of Proximal Renal Tubular Function of "Real World" Chronic Hepatitis B (CHB) Patients Who Are Suppressed on TDF and Switched to TAF	Unknown status	NCT02957994	Phase 4	Tenofovir alafenamide fumarate
44	Effects of Dapagliflozin on Hyperlipidemia, Glycemic Control and Insulin Resistance in Type 2 Diabetic Patients (DAPHNIS Study)	Unknown status	NCT02577159	Phase 4	Dapagliflozin
45	Effect of Vitamin D Supplementation on Bone Turnover Markers During Tenofovir-Emtricitibine Pre-Exposure Prophylaxis in Men Who Have Sex With Men; A Sub-study of CCTG 595	Unknown status	NCT02367599	Phase 4	Vitamin D Supplement
46	Adductor Canal Block Versus Femoral Nerve Block for Analgesia After Anterior Cruciate Ligament Reconstruction Arthroscopically	Unknown status	NCT02355093	Phase 4	ropivacaine
47	A Randomised Trial Comparing Entacavir and Tenofovir in Patients With HBV Decompensated Cirrhosis	Unknown status	NCT02238860	Phase 4	Entacavir;Tenofovir
48	Antibiotic Prophylaxis in Prosthetic Breast Reconstructions	Unknown status	NCT02012517	Phase 4	Prolonged antibiotic treatment;Short antibiotic course (standard of care)
49	Albumin Infusion Effects in Mortality in Patients With Cirrhosis and Hepatic Encephalopathy	Unknown status	NCT02401490	Phase 4	Human albumin;Placebo
50	Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism in ARV-naive HIV-infected Subjects	Unknown status	NCT00759070	Phase 4	Tenofovir + emtricitabine + efavirenz;Tenofovir + emtricitabine + lopinavir/ritonavir

Search NIH Clinical Center for 48,xyyy

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Genetic Tests for 48,xyyy

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Anatomical Context for 48,xyyy

MalaCards organs/tissues related to 48,xyyy:

⁴⁰

Testes, Liver, Lung, Brain, Breast, Kidney, Heart

Sources

Publications for 48,xyyy

Articles related to 48,xyyy:

(show top 50) (show all 30000)

#	Title	Authors	PMID	Year
1	Diosgenin and 4-Hydroxyisoleucine from Fenugreek Are Regulators of Genes Involved in Lipid Metabolism in The Human Colorectal Cancer Cell Line SW480. ⁶¹	Mohammad-Sadeghipour M...Hajizadeh MR	32347045	2021
2	The enhanced removal of phosphate by structural defects and competitive fluoride adsorption on cerium-based adsorbent. ⁶¹	He J...Yang L	32447108	2020
3	Antibacterial Properties and Application of Nanosilver Material in the Tracheal Tube. ⁶¹	Hu Y...Deng J	32385011	2020
4	Ambient fine particulate matter pollution and years of life lost from cardiovascular diseases in 48 large Chinese cities: Association, effect modification, and additional life gain. ⁶¹	Li J...Zhou M	32480149	2020
5	GPR17 plays a role in ischemia-induced endogenous repair of immature neonatal cerebral White matter. ⁶¹	Mao FX...Buzby JS	32387084	2020
6	Modulation of chloroplast components and defense responses during programmed cell death in tobacco infected with Pseudomonas syringae. ⁶¹	Tran BQ...Jung S	32527587	2020
7	Positive effect of natural antioxidant oregonin from Alnus incana bark on ram semen quality stored at 5 °C for 48 h. ⁶¹	Abadjieva D...Kistanova E	32387554	2020
8	Insight into the role of integrated carbohydrate polymers (starch, chitosan, and β-cyclodextrin) with mesoporous silica as carriers for ibuprofen drug; equilibrium and pharmacokinetic properties. ⁶¹	Abukhadra MR...Ibrahim KE	32294500	2020
9	Testicular hyperthermia reduces testosterone concentrations and alters gene expression in testes of Nelore bulls. ⁶¹	Rizzoto G...Kastelic JP	32380276	2020
10	Assessing the acute and chronic toxicity of exposure to naturally occurring oil sands deposits to aquatic organisms using Daphnia magna. ⁶¹	Cardoso DN...Loureiro S	32380325	2020
11	The efficacy of hepatitis B treatments in achieving HBsAg seroclearance: A systematic review and meta-analysis. ⁶¹	Fonseca MA...Lim SG	32170983	2020
12	Prediction of the need for phototherapy during hospital stay in preterm infants by transcutaneous bilirubinometry. ⁶¹	Raba AA...Miletin J	32442814	2020
13	Diagnostic value of bronchoalveolar lavage and bronchial washing in sputum-scarce or smear-negative cases with suspected pulmonary tuberculosis: a randomized study. ⁶¹	Kim YW...Park JS	31759097	2020
14	Incidence of postoperative pain after canal shaping by using Reciproc and Twisted File Adaptive systems: a prospective, randomized clinical trial. ⁶¹	AlOmari T...Jamleh A	31673858	2020
15	Effectiveness of boosted darunavir plus rilpivirine in patients with long-lasting HIV-1 infection: DARIL study. ⁶¹	Navarro J...Ribera E	32134108	2020
16	Characterization of viral rebounds on dual etravirine/raltegravir maintenance therapy (ANRS-163 ETRAL trial). ⁶¹	Soulie C...ANRS-163 ETRAL study group	32259255	2020
17	Motility and Fertility Evaluation of Thawed Frozen Stallion Semen After 24 Hours of Cooled Storage. ⁶¹	Prell MJ...Graham JK	32534766	2020
18	Betahistine in the Treatment of Peripheral Vestibular Vertigo: Results of a Real-Life Study in Primary Care. ⁶¹	Sanchez-Vanegas G...Buitrago D	31111729	2020
19	Evidence that activin A directly modulates early human male germline differentiation status. ⁶¹	Moody SC...Loveland KL	32484162	2020
20	Clinical evaluation of an immunochromatographic IgM/IgG antibody assay and chest computed tomography for the diagnosis of COVID-19. ⁶¹	Imai K...Maeda T	32387968	2020
21	Diagnostic performance between CT and initial real-time RT-PCR for clinically suspected 2019 coronavirus disease (COVID-19) patients outside Wuhan, China. ⁶¹	He JL...Wen Z	32364959	2020
22	18F-FDG PET/CT in Follicular Dendritic Cell Sarcoma With Paraneoplastic Pemphigus as the First Manifestation. ⁶¹	Chen X...Li Q	32371617	2020
23	Ketoprofen affects swimming behavior and impairs physiological endpoints of Daphnia magna. ⁶¹	Bownik A...Kosztowny E	32304961	2020
24	Effectiveness of Switching to Darunavir/Cobicistat in Virologically Suppressed HIV-Positive Patients Receiving Ritonavir-Boosted Protease Inhibitor-Based Regimen: The "STORE" Study. ⁶¹	Gori A...Mancusi D	32101882	2020
25	Virulence, antimicrobial resistance and phylogenetic analysis of zoonotic walking pneumonia Mycoplasma arginini in the one-humped camel (Camelus dromedarius). ⁶¹	Abdelazeem WM...Osman KM	32330451	2020
26	Safety and effectiveness of medication and aspiration abortion before or during the sixth week of pregnancy: A retrospective multicenter study. ⁶¹	Baldwin MK...Russo J	32298713	2020
27	DAMGO-induced μ opioid receptor internalization and recycling restore morphine sensitivity in tolerant rat. ⁶¹	Ma X...Xu T	32320702	2020
28	Assessment of cyto- and genotoxic effects of Cesium-133 in Vicia faba using single-cell gel electrophoresis and random amplified polymorphic DNA assays. ⁶¹	Zhang Y...Luo XG	32311615	2020
29	Tenofovir alafenamide after switching from entecavir or nucleos(t)ide combination therapy for patients with chronic hepatitis B. ⁶¹	Ogawa E...Kyushu University Liver Disease Study (KULDS) Group	32304611	2020
30	Correction to: Transcriptional and metabolite analysis reveal a shift in direct and indirect defences in response to spider‑mite infestation in cucumber (Cucumis sativus). ⁶¹	He J...Kappers IF	32350663	2020
31	Effect of self-performed mechanical plaque control frequency on gingival health in subjects with a history of periodontitis: A Randomized Clinical Trial. ⁶¹	Maier J...Moreira CHC	32315448	2020
32	How successful are we in relieving terminal dyspnea in cancer patients? A real-world multicenter prospective observational study. ⁶¹	Mori M...Iwase S	31630256	2020
33	Efficacy and safety of edoxaban compared with warfarin according to the burden of diseases in patients with atrial fibrillation: insights from the ENGAGE AF-TIMI 48 trial. ⁶¹	Nicolau AM...Giugliano RP	31687762	2020
34	Transporting and Exercising Unconditioned Horses: Effects on Microflora Populations. ⁶¹	Szemplinski KL...Jones T	32534767	2020
35	Intravenous Ibuprofen Reduces Opioid Consumption During the Initial 48 Hours After Injury in Orthopedic Trauma Patients. ⁶¹	Weisz RD...Puente I	31929374	2020
36	OXA-48 carbapenemase-producing Salmonella enterica serovar Kentucky ST198 isolated from Saudi Arabia. ⁶¹	Alghoribi MF...Doumith M	32154842	2020
37	Carbapenem Resistance Conferred by OXA-48 in K2-ST86 Hypervirulent Klebsiella pneumoniae, France. ⁶¹	Beyrouthy R...Bonnet R	32568057	2020
38	Assessment of the Urinary Microbiome in Children Younger Than 48 Months. ⁶¹	Kinneman L...Hourigan SK	32091499	2020
39	DEX-2-TKA - DEXamethasone twice for pain treatment after Total Knee Arthroplasty: Detailed statistical analysis plan for a randomized, blinded, three-group multicentre clinical trial. ⁶¹	Gasbjerg KS...Jakobsen JC	32048274	2020
40	An examination of changes in skeletal muscle thickness, echo intensity, strength and soreness following resistance exercise. ⁶¹	Yitzchaki N...Buckner SL	32187417	2020
41	Risk Factors of Nonunion After Acute Osteoporotic Vertebral Fractures: A Prospective Multicenter Cohort Study. ⁶¹	Inose H...Okawa A	32044808	2020
42	Clinical and pathological features and varied mutational spectra of pathogenic genes in 55 Chinese patients with nephronophthisis. ⁶¹	Yue Z...Sun L	32173348	2020
43	Randomized trial of argatroban plus recombinant tissue-type plasminogen activator for acute ischemic stroke (ARAIS): Rationale and design. ⁶¹	Yang Y...ARAIS Protocol Steering Group	32485328	2020
44	Maintenance of clinical remission in early axial spondyloarthritis following certolizumab pegol dose reduction. ⁶¹	Landewe RB...Gensler L	32381562	2020
45	Early postnatal changes of circulating N-terminal-pro-B-type natriuretic peptide in neonates with congenital diaphragmatic hernia. ⁶¹	Heindel K...Kipfmueller F	32402829	2020
46	In vitro evaluation of physicochemical properties of soft lining resins after incorporation of chlorhexidine. ⁶¹	Maluf CV...Telles DM	32540125	2020
47	Assessing the effectiveness of AS-48 in experimental mice models of Chagas' disease. ⁶¹	Martin-Escolano R...Marin C	32129856	2020
48	Quantitative and Qualitative Assessments of Cholesterol Association With Bacterial Infection Type in Sepsis and Septic Shock. ⁶¹	Black LP...Guirgis FW	32578468	2020
49	Treatment of a tuberculous esophagomediastinal fistula with a covered metal stent. ⁶¹	Yu G...Yang J	32579016	2020
50	Evaluation of Prognostic Factors of Severity in Acute Biliary Pancreatitis. ⁶¹	Silva-Vaz P...Tralhao JG	32560276	2020

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Expression for 48,xyyy

Search GEO for disease gene expression data for 48,xyyy.

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