MCID: 6PH001
MIFTS: 29

6-Phosphogluconate Dehydrogenase Deficiency

Categories: Blood diseases, Rare diseases

Aliases & Classifications for 6-Phosphogluconate Dehydrogenase Deficiency

MalaCards integrated aliases for 6-Phosphogluconate Dehydrogenase Deficiency:

Name: 6-Phosphogluconate Dehydrogenase Deficiency 59
6-Phosphogluconate Dehydrogenase 13

Classifications:



External Ids:

Orphanet 59 ORPHA99135
ICD10 via Orphanet 34 D55.1

Summaries for 6-Phosphogluconate Dehydrogenase Deficiency

MalaCards based summary : 6-Phosphogluconate Dehydrogenase Deficiency, also known as 6-phosphogluconate dehydrogenase, is related to neutrophil actin dysfunction and aging. An important gene associated with 6-Phosphogluconate Dehydrogenase Deficiency is G6PD (Glucose-6-Phosphate Dehydrogenase), and among its related pathways/superpathways are Glycosaminoglycan metabolism and Glucose / Energy Metabolism. Affiliated tissues include liver, lung and breast.

Wikipedia : 76 6-Phosphogluconate dehydrogenase deficiency (6PGD deficiency), or partial deficiency, is an autosomal... more...

Related Diseases for 6-Phosphogluconate Dehydrogenase Deficiency

Diseases related to 6-Phosphogluconate Dehydrogenase Deficiency via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 neutrophil actin dysfunction 10.2
2 aging 10.2
3 cervical cancer 10.2
4 malaria 10.2
5 breast cancer 10.0
6 6-phosphogluconolactonase deficiency 10.0
7 suppressor of tumorigenicity 3 10.0
8 lung cancer 10.0
9 leukemia, acute myeloid 10.0
10 hemolytic anemia 10.0
11 leukemia 10.0
12 sleeping sickness 10.0
13 trypanosomiasis 10.0
14 thyroid cancer 10.0
15 myeloid leukemia 10.0
16 in situ carcinoma 10.0
17 anaplastic thyroid cancer 10.0
18 cervical intraepithelial neoplasia 10.0
19 haemophilus influenzae 10.0
20 trypanosomiasis, human east-african 10.0
21 glucosephosphate dehydrogenase deficiency 9.7 G6PD PGD

Graphical network of the top 20 diseases related to 6-Phosphogluconate Dehydrogenase Deficiency:



Diseases related to 6-Phosphogluconate Dehydrogenase Deficiency

Symptoms & Phenotypes for 6-Phosphogluconate Dehydrogenase Deficiency

Drugs & Therapeutics for 6-Phosphogluconate Dehydrogenase Deficiency

Search Clinical Trials , NIH Clinical Center for 6-Phosphogluconate Dehydrogenase Deficiency

Genetic Tests for 6-Phosphogluconate Dehydrogenase Deficiency

Anatomical Context for 6-Phosphogluconate Dehydrogenase Deficiency

MalaCards organs/tissues related to 6-Phosphogluconate Dehydrogenase Deficiency:

41
Liver, Lung, Breast, Testes, Thyroid, Myeloid, Kidney

Publications for 6-Phosphogluconate Dehydrogenase Deficiency

Articles related to 6-Phosphogluconate Dehydrogenase Deficiency:

(show top 50) (show all 410)
# Title Authors Year
1
Inhibiting 6-phosphogluconate dehydrogenase enhances chemotherapy efficacy in cervical cancer via AMPK-independent inhibition of RhoA and Rac1. ( 30182212 )
2018
2
Inhibiting 6-phosphogluconate dehydrogenase selectively targets breast cancer through AMPK activation. ( 29340974 )
2018
3
The synthesis of N-benzoylindoles as inhibitors of rat erythrocyte glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase. ( 29992784 )
2018
4
Characterization of Plasmodium falciparum 6-Phosphogluconate Dehydrogenase as an Antimalarial Drug Target. ( 30098336 )
2018
5
Single Amino Acid Change in 6-Phosphogluconate Dehydrogenase from Synechocystis Conveys Higher Affinity for NADP+ and Altered Mode of Inhibition by NADPH. ( 30107441 )
2018
6
Deletion of gene gnd encoding 6-phosphogluconate dehydrogenase promotes L-serine biosynthesis in a genetically engineered strain of Methylobacterium sp. MB200. ( 30361889 )
2018
7
In vitro and in vivo effects of iron on the expression and activity of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase in rat spleen. ( 30506659 )
2018
8
Targeting 6-phosphogluconate dehydrogenase in the oxidative PPP sensitizes leukemia cells to antimalarial agent dihydroartemisinin. ( 27270429 )
2017
9
Co-production of hydrogen and ethanol from glucose in Escherichia coli by activation of pentose-phosphate pathway through deletion of phosphoglucose isomerase (pgi) and overexpression of glucose-6-phosphate dehydrogenase (zwf) and 6-phosphogluconate dehydrogenase (gnd). ( 28360941 )
2017
10
Inhibition of 6-phosphogluconate Dehydrogenase Reverses Cisplatin Resistance in Ovarian and Lung Cancer. ( 28713273 )
2017
11
High-Throughput Screening of Coenzyme Preference Change of Thermophilic 6-Phosphogluconate Dehydrogenase from NADP(+) to NAD(.). ( 27587230 )
2016
12
Coenzyme Engineering of a Hyperthermophilic 6-Phosphogluconate Dehydrogenase from NADP+ to NAD+ with Its Application to Biobatteries. ( 27805055 )
2016
13
Purification and biochemical characterization of glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and glutathione reductase from rat lung and inhibition effects of some antibiotics. ( 26758606 )
2016
14
Purification and Characterization of Glucose 6-Phosphate Dehydrogenase, 6-Phosphogluconate Dehydrogenase, and Glutathione Reductase from Rat Heart and Inhibition Effects of Furosemide, Digoxin, and Dopamine on the Enzymes Activities. ( 26820767 )
2016
15
Defects in Peroxisomal 6-Phosphogluconate Dehydrogenase Isoform PGD2 Prevent Gametophytic Interaction in Arabidopsis thaliana. ( 26941195 )
2016
16
In Silico Analysis of Arabidopsis thaliana Peroxisomal 6-Phosphogluconate Dehydrogenase. ( 27034898 )
2016
17
Improving ethanol yield in acetate-reducing Saccharomyces cerevisiae by cofactor engineering of 6-phosphogluconate dehydrogenase and deletion of ALD6. ( 27118055 )
2016
18
Analysis of homo- and hetero-dimerization among the three 6-phosphogluconate dehydrogenase isoforms of Arabidopsis. ( 27366940 )
2016
19
Examination of changes in enzyme activities of erythrocyte glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in rats given Naringenin and Lead acetate. ( 25228019 )
2015
20
Escherichia coli 6-phosphogluconate dehydrogenase aids in tellurite resistance by reducing the toxicant in a NADPH-dependent manner. ( 26211962 )
2015
21
Energy cost for the proper ionization of active site residues in 6-phosphogluconate dehydrogenase from T. brucei. ( 24568863 )
2014
22
Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in oxidative stress induced by long-term iron toxicity in rat liver. ( 24599681 )
2014
23
Purification and characterization of 6-phosphogluconate dehydrogenase from the wing-polymorphic cricket, Gryllus firmus, and assessment of causes of morph-differences in enzyme activity. ( 24726622 )
2014
24
Investigation of the effects of some phenolic compounds on the activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase from human erythrocytes. ( 25130191 )
2014
25
Chloroplast-localized 6-phosphogluconate dehydrogenase is critical for maize endosperm starch accumulation. ( 23530131 )
2013
26
Evidence for dimer/tetramer equilibrium in Trypanosoma brucei 6-phosphogluconate dehydrogenase. ( 24096100 )
2013
27
Purification and characterization of 6-phosphogluconate dehydrogenase (6-PGD) from grass carp (Ctenopharyngodon idella) hepatopancreas. ( 24772981 )
2013
28
Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate dehydrogenase, of Haemophilus parasuis. ( 21840023 )
2012
29
Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. ( 21930213 )
2012
30
Alternative splicing directs dual localization of Candida albicans 6-phosphogluconate dehydrogenase to cytosol and peroxisomes. ( 22094058 )
2012
31
Coordinated regulation of gnd, which encodes 6-phosphogluconate dehydrogenase, by the two transcriptional regulators GntR1 and RamA in Corynebacterium glutamicum. ( 23024346 )
2012
32
Conformational changes associated with cofactor/substrate binding of 6-phosphogluconate dehydrogenase from Escherichia coli and Klebsiella pneumoniae: Implications for enzyme mechanism. ( 19686854 )
2010
33
6-Phosphogluconate dehydrogenase mechanism: evidence for allosteric modulation by substrate. ( 20452987 )
2010
34
Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. ( 20598892 )
2010
35
Enzymatic and mRNA transcript response of ovine 6-phosphogluconate dehydrogenase (6PGD) in respect to different weights from weaning to four months of age. ( 20665286 )
2010
36
The 6-phosphogluconate dehydrogenase of Leishmania (Leishmania) mexicana: gene characterization and protein structure prediction. ( 21160204 )
2010
37
Enzymatic and mRNA Transcript Response of Ovine 6-Phosphogluconate Dehydrogenase (6PGD) in Respect to Different Milk Yield. ( 21188075 )
2010
38
Geobacillus stearothermophilus 6-phosphogluconate dehydrogenase complexed with 6-phosphogluconate. ( 19407374 )
2009
39
Overexpression and simple purification of the Thermotoga maritima 6-phosphogluconate dehydrogenase in Escherichia coli and its application for NADPH regeneration. ( 19497097 )
2009
40
Proper orientation of the nicotinamide ring of NADP is important for the precatalytic conformational change in the 6-phosphogluconate dehydrogenase reaction. ( 18205398 )
2008
41
Effects of nicotine and vitamin E on 6-phosphogluconate dehydrogenase activity in some rat tissues in vivo and in vitro. ( 18343913 )
2008
42
Cloning, expression and characterization of a cell wall surface protein, 6-phosphogluconate-dehydrogenase, of Streptococcus suis serotype 2. ( 18403138 )
2008
43
Expression of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase isoform genes in suspension-cultured Arabidopsis thaliana cells. ( 19040112 )
2008
44
Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates. ( 17222187 )
2007
45
Inhibitory effects of ofloxacin and cefepime on enzyme activity of 6-phosphogluconate dehydrogenase from chicken liver. ( 17305608 )
2007
46
Thermodynamic characterization of substrate and inhibitor binding to Trypanosoma brucei 6-phosphogluconate dehydrogenase. ( 18021252 )
2007
47
Effects of some drugs on human erythrocyte 6-phosphogluconate dehydrogenase: an in vitro study. ( 18237031 )
2007
48
Gender- and age-related changes in 6-phosphogluconate dehydrogenase gene expression in white adipose tissue of rats (Rattus norvegicus) are not related to serum testosterone concentration. ( 16492403 )
2006
49
Catalytic mechanism of 6-phosphogluconate dehydrogenase: a theoretical investigation. ( 16571018 )
2006
50
Importance in catalysis of the 6-phosphate-binding site of 6-phosphogluconate in sheep liver 6-phosphogluconate dehydrogenase. ( 16803886 )
2006

Variations for 6-Phosphogluconate Dehydrogenase Deficiency

Expression for 6-Phosphogluconate Dehydrogenase Deficiency

Search GEO for disease gene expression data for 6-Phosphogluconate Dehydrogenase Deficiency.

Pathways for 6-Phosphogluconate Dehydrogenase Deficiency

GO Terms for 6-Phosphogluconate Dehydrogenase Deficiency

Biological processes related to 6-Phosphogluconate Dehydrogenase Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 9.26 G6PD PGD
2 pentose-phosphate shunt GO:0006098 9.16 G6PD PGD
3 pentose-phosphate shunt, oxidative branch GO:0009051 8.96 G6PD PGD
4 pentose biosynthetic process GO:0019322 8.62 G6PD PGD

Molecular functions related to 6-Phosphogluconate Dehydrogenase Deficiency according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.96 G6PD PGD
2 NADP binding GO:0050661 8.62 G6PD PGD

Sources for 6-Phosphogluconate Dehydrogenase Deficiency

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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