MCID: 8P1002
MIFTS: 46

8p11 Myeloproliferative Syndrome

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for 8p11 Myeloproliferative Syndrome

MalaCards integrated aliases for 8p11 Myeloproliferative Syndrome:

Name: 8p11 Myeloproliferative Syndrome 25
Myeloid and Lymphoid Neoplasms with Fgfr1 Abnormalities 25
Myeloid and Lymphoid Neoplasms with Fgfr1 Rearrangement 73
Chromosome 8p11 Myeloproliferative Syndrome 73
8p11 Stem Cell Leukemia/lymphoma Syndrome 25
Stem Cell Leukemia/lymphoma 25
8p11 Stem Cell Syndrome 25

Classifications:



External Ids:

Summaries for 8p11 Myeloproliferative Syndrome

Genetics Home Reference : 25 8p11 myeloproliferative syndrome is a blood cancer that involves different types of blood cells. Blood cells are divided into several groups (lineages) based on the type of early cell from which they are descended. Two of these lineages are myeloid cells and lymphoid cells. Individuals with 8p11 myeloproliferative syndrome can develop both myeloid cell cancer and lymphoid cell cancer.

MalaCards based summary : 8p11 Myeloproliferative Syndrome, also known as myeloid and lymphoid neoplasms with fgfr1 abnormalities, is related to chromosome 8p11 myeloproliferative syndrome and leukemia. An important gene associated with 8p11 Myeloproliferative Syndrome is FGFR1 (Fibroblast Growth Factor Receptor 1), and among its related pathways/superpathways are HIV Life Cycle and Cytokine Signaling in Immune system. Affiliated tissues include myeloid, bone and b cells, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for 8p11 Myeloproliferative Syndrome

Diseases in the 8p11 Myeloproliferative Syndrome family:

Myeloproliferative Syndrome, Transient Myeloproliferative Disease, Autosomal Recessive

Diseases related to 8p11 Myeloproliferative Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 chromosome 8p11 myeloproliferative syndrome 34.4 FGFR1 SCLL
2 leukemia 30.4 BCR FLT3 KIT RUNX1
3 leukemia, acute lymphoblastic 30.2 BCR FLT3 RUNX1
4 acute leukemia 30.2 FLT3 KIT RUNX1
5 myeloid leukemia 30.1 BCR FLT3 KIT RUNX1
6 leukemia, acute myeloid 30.0 BCR FLT3 KIT RUNX1 ZMYM2
7 acute myeloblastic leukemia with maturation 10.2 FLT3 KIT
8 primary hypereosinophilic syndrome 10.2 FGFR1 PDGFRB
9 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.2 FGFR1 PDGFRB
10 hematopoietic stem cell transplantation 10.1
11 lymphoblastic lymphoma 10.1
12 lymphoma 10.1
13 lymphocytic leukemia 10.1
14 desmoid tumor 10.1 KIT PDGFRB
15 hypereosinophilic syndrome, idiopathic 10.1 KIT PDGFRB
16 systemic mastocytosis 10.1 FGFR1 KIT PDGFRB
17 hypereosinophilic syndrome 10.1 FGFR1 KIT PDGFRB
18 acute myeloid leukemia with t(8;21)(q22;q22) translocation 10.1 FLT3 KIT RUNX1
19 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 10.0 FLT3 KIT RUNX1
20 core binding factor acute myeloid leukemia 10.0 FLT3 KIT RUNX1
21 pulmonary vein stenosis 10.0 KDR KIT
22 leukemia, acute lymphoblastic 3 10.0 BCR FLT3 RUNX1
23 senile angioma 10.0 KDR KIT
24 chronic eosinophilic leukemia 10.0 FGFR1 FLT3 KIT PDGFRB
25 myeloproliferative neoplasm 10.0 BCR FGFR1 KIT PDGFRB
26 fibrosarcoma of bone 10.0 KDR KIT PDGFRB
27 vascular cancer 10.0 KDR KIT PDGFRB
28 heart sarcoma 9.9 KIT PDGFRB
29 juvenile myelomonocytic leukemia 9.9 FLT3 PDGFRB RUNX1
30 chronic myelomonocytic leukemia 9.9 FLT3 KIT PDGFRB RUNX1
31 gastrointestinal stromal tumor 9.9 FLT3 KIT PDGFRB
32 adenocarcinoma 9.8 FGFR1 KDR KIT PDGFRB
33 renal cell carcinoma, nonpapillary 9.8 FLT3 KDR KIT PDGFRB
34 myelodysplastic syndrome 9.8 FLT3 KIT PDGFRB RUNX1
35 leukemia, chronic myeloid 9.7 BCR FGFR1 FLT3 KIT PDGFRB RUNX1
36 hematologic cancer 9.5 BCR FGFR1 FLT3 KDR KIT PDGFRB
37 bone marrow cancer 9.3 BCR FGFR1 FGFR1OP FLT3 KDR KIT

Graphical network of the top 20 diseases related to 8p11 Myeloproliferative Syndrome:



Diseases related to 8p11 Myeloproliferative Syndrome

Symptoms & Phenotypes for 8p11 Myeloproliferative Syndrome

GenomeRNAi Phenotypes related to 8p11 Myeloproliferative Syndrome according to GeneCards Suite gene sharing:

26 (show all 39)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.96 FLT3
2 Decreased viability GR00221-A-1 9.96 FGFR1 FLT3 KDR KIT PDGFRB
3 Decreased viability GR00221-A-2 9.96 FGFR1 KDR
4 Decreased viability GR00221-A-3 9.96 KDR PDGFRB
5 Decreased viability GR00221-A-4 9.96 FLT3 KDR PDGFRB
6 Decreased viability GR00301-A 9.96 KIT
7 Decreased viability GR00342-S-1 9.96 PDGFRB
8 Decreased viability GR00402-S-2 9.96 FGFR1 FLT3 KDR KIT PDGFRB
9 Increased shRNA abundance (Z-score > 2) GR00366-A-100 9.83 BCR
10 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.83 KIT
11 Increased shRNA abundance (Z-score > 2) GR00366-A-105 9.83 TPR
12 Increased shRNA abundance (Z-score > 2) GR00366-A-115 9.83 BCR
13 Increased shRNA abundance (Z-score > 2) GR00366-A-121 9.83 TPR
14 Increased shRNA abundance (Z-score > 2) GR00366-A-122 9.83 BCR
15 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.83 TRIM24
16 Increased shRNA abundance (Z-score > 2) GR00366-A-124 9.83 BCR
17 Increased shRNA abundance (Z-score > 2) GR00366-A-125 9.83 KDR TRIM24
18 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.83 TRIM24
19 Increased shRNA abundance (Z-score > 2) GR00366-A-152 9.83 KIT
20 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.83 KIT
21 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.83 BCR
22 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.83 BCR
23 Increased shRNA abundance (Z-score > 2) GR00366-A-170 9.83 KIT
24 Increased shRNA abundance (Z-score > 2) GR00366-A-2 9.83 BCR
25 Increased shRNA abundance (Z-score > 2) GR00366-A-205 9.83 TPR
26 Increased shRNA abundance (Z-score > 2) GR00366-A-215 9.83 BCR
27 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.83 BCR
28 Increased shRNA abundance (Z-score > 2) GR00366-A-30 9.83 KIT
29 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.83 KDR
30 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.83 KIT
31 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.83 TRIM24
32 Increased shRNA abundance (Z-score > 2) GR00366-A-83 9.83 BCR
33 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.83 BCR KDR KIT TPR TRIM24
34 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.83 KIT
35 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.83 KIT
36 Decreased substrate adherent cell growth GR00193-A-1 9.63 KIT
37 Decreased substrate adherent cell growth GR00193-A-2 9.63 KIT
38 Decreased substrate adherent cell growth GR00193-A-4 9.63 FGFR1 FLT3 KDR KIT
39 Decreased human cytomegalovirus (HCMV) strain AD169 replication GR00248-A 9.56 FGFR1 FLT3 KDR PDGFRB

MGI Mouse Phenotypes related to 8p11 Myeloproliferative Syndrome:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.11 BCR FGF1 FGFR1 FGFR1OP FLT3 KDR
2 hematopoietic system MP:0005397 10.1 BCR FGF1 FGFR1 FGFR1OP FLT3 KDR
3 cardiovascular system MP:0005385 10.03 CNTRL FGFR1 FGFR1OP KDR KIT MYO18A
4 immune system MP:0005387 9.97 BCR FGFR1 FGFR1OP FLT3 KDR KIT
5 integument MP:0010771 9.8 FGFR1 KDR KIT MYO18A NSMAF PDGFRB
6 mortality/aging MP:0010768 9.7 BCR FGFR1 FGFR1OP FLT3 KDR KIT
7 liver/biliary system MP:0005370 9.63 BCR KDR KIT MYO18A RUNX1 TRIM24
8 vision/eye MP:0005391 9.17 CNTRL FGFR1 FGFR1OP KDR KIT MYO18A

Drugs & Therapeutics for 8p11 Myeloproliferative Syndrome

Search Clinical Trials , NIH Clinical Center for 8p11 Myeloproliferative Syndrome

Genetic Tests for 8p11 Myeloproliferative Syndrome

Anatomical Context for 8p11 Myeloproliferative Syndrome

MalaCards organs/tissues related to 8p11 Myeloproliferative Syndrome:

41
Myeloid, Bone, B Cells, Bone Marrow, Lung, Heart

Publications for 8p11 Myeloproliferative Syndrome

Articles related to 8p11 Myeloproliferative Syndrome:

(show all 38)
# Title Authors Year
1
8p11 Myeloproliferative syndrome with t(8;22)(p11;q11): A case report. ( 30116393 )
2018
2
Allogeneic hematopoietic stem cell transplantation for 8p11 myeloproliferative syndrome with BCR-FGFR1 gene rearrangement: a case report and literature review. ( 30087462 )
2018
3
8p11 Stem Cell Leukemia/Lymphoma Syndrome without Myeloproliferation: A Rare Clinical Entity. ( 29622897 )
2018
4
Primary cells in BCR/FGFR1 positive 8p11 myeloproliferative syndrome are sensitive to dovitinib, ponatinib, and dasatinib. ( 28881484 )
2017
5
8p11 Myeloproliferative Syndrome with t(7;8) Translocation Presenting as Acute Myeloid Leukemia: A Case Report and Literature Review. ( 27188774 )
2016
6
Diagnostic application of next-generation sequencing in ZMYM2-FGFR1 8p11 myeloproliferative syndrome: A case report. ( 27415155 )
2016
7
8p11 myeloproliferative syndrome: diagnostic challenges and pitfalls. ( 27569099 )
2016
8
8p11 myeloproliferative syndrome: A case report of this rare clinical entity. ( 25885151 )
2015
9
Screening of Drugs to Treat 8p11 Myeloproliferative Syndrome Using Patient-Derived Induced Pluripotent Stem Cells with Fusion Gene CEP110-FGFR1. ( 25803811 )
2015
10
Functional characterization, localization, and inhibitor sensitivity of the TPR-FGFR1 fusion in 8p11 myeloproliferative syndrome. ( 26391436 )
2015
11
8p11 Myeloproliferative Syndrome with t(1;8)(q25;p11.2): A Case Report and Review of the Literature. ( 25227135 )
2014
12
A case of 8p11 myeloproliferative syndrome with BCR-FGFR1 gene fusion presenting with trilineage acute leukemia/lymphoma, successfully treated by cord blood transplantation. ( 23171834 )
2013
13
Ponatinib as targeted therapy for FGFR1 fusions associated with the 8p11 myeloproliferative syndrome. ( 22875613 )
2013
14
Quantitative polymerase chain reaction detection of CEP110-FGFR1 fusion gene in a patient with 8p11 myeloproliferative syndrome. ( 23327291 )
2013
15
A novel t(1;8)(q25;p11.2) translocation associated with 8p11 myeloproliferative syndrome. ( 21848523 )
2012
16
Favorable outcome of allogeneic hematopoietic cell transplantation for 8p11 myeloproliferative syndrome associated with BCR-FGFR1 gene fusion. ( 22106025 )
2012
17
Identification of a novel partner gene, TPR, fused to FGFR1 in 8p11 myeloproliferative syndrome. ( 22619110 )
2012
18
The 8p11 myeloproliferative syndrome owing to rare FGFR1OP2-FGFR1 fusion. ( 21198859 )
2011
19
8p11 Myeloproliferative syndrome with BCR-FGFR1 rearrangement presenting with T-lymphoblastic lymphoma and bone marrow stromal cell proliferation: a case report and review of the literature. ( 21239058 )
2011
20
Translocation t(3;8;9)(p25;p21;q34) in a patient with features of 8p11 myeloproliferative syndrome: a unique case and review of the literature. ( 20541805 )
2010
21
8p11 myeloproliferative syndrome: a review. ( 20226962 )
2010
22
B-cell acute lymphoblastic leukemia as evolution of a 8p11 myeloproliferative syndrome with t(8;22)(p11;q11) and BCR-FGFR1 fusion gene. ( 20594995 )
2010
23
Modeling the human 8p11-myeloproliferative syndrome in immunodeficient mice. ( 20554971 )
2010
24
Biphenotypic hematologic malignancy: a case report of the 8p11 myeloproliferative syndrome in a child. ( 20562652 )
2010
25
Complete molecular remission after interferon alpha treatment in a case of 8p11 myeloproliferative syndrome. ( 20650528 )
2010
26
LRRFIP1, a new FGFR1 partner gene associated with 8p11 myeloproliferative syndrome. ( 19369959 )
2009
27
Molecular monitoring of 8p11 myeloproliferative syndrome in an infant. ( 19829149 )
2009
28
The 8p11 myeloproliferative syndrome in a 3-year-old child. ( 17555813 )
2008
29
8p11 myeloproliferative syndrome preceded by t(8;9)(p11;q33), CEP110/FGFR1 fusion transcript: morphologic, molecular, and cytogenetic characterization of myeloid neoplasms associated with eosinophilia and FGFR1 abnormality. ( 18295660 )
2008
30
The 8p11 myeloproliferative syndrome: review of literature and an illustrative case report. ( 18787627 )
2008
31
Fusion gene-mediated truncation of RUNX1 as a potential mechanism underlying disease progression in the 8p11 myeloproliferative syndrome. ( 17394134 )
2007
32
Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome. ( 17698633 )
2007
33
A biphenotypic transformation of 8p11 myeloproliferative syndrome with CEP1/FGFR1 fusion gene. ( 16879608 )
2006
34
8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes. ( 15609342 )
2005
35
The t(8;17)(p11;q23) in the 8p11 myeloproliferative syndrome fuses MYO18A to FGFR1. ( 15800673 )
2005
36
Identification of a novel gene, FGFR1OP2, fused to FGFR1 in 8p11 myeloproliferative syndrome. ( 15034873 )
2004
37
The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1. ( 11919391 )
2002
38
[The 8p11 myeloproliferative syndrome]. ( 10373756 )
1999

Variations for 8p11 Myeloproliferative Syndrome

Expression for 8p11 Myeloproliferative Syndrome

Search GEO for disease gene expression data for 8p11 Myeloproliferative Syndrome.

Pathways for 8p11 Myeloproliferative Syndrome

Pathways related to 8p11 Myeloproliferative Syndrome according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 BCR CNTRL FGF1 FGFR1 FGFR1OP FGFR1OP2
2
Show member pathways
13.21 FGF1 FGFR1 FLT3 KIT PDGFRB TPR
3
Show member pathways
13.17 FGF1 FGFR1 FLT3 KDR KIT PDGFRB
4
Show member pathways
13.12 FGF1 FGFR1 FLT3 KDR KIT PDGFRB
5
Show member pathways
12.91 FGF1 FGFR1 KDR KIT PDGFRB
6
Show member pathways
12.9 FGF1 FGFR1 KDR KIT PDGFRB
7
Show member pathways
12.89 FGF1 FGFR1 FLT3 KDR KIT PDGFRB
8
Show member pathways
12.83 FGFR1 FLT3 KDR KIT PDGFRB
9
Show member pathways
12.72 BCR FGFR1 FLT3 KIT PDGFRB RUNX1
10 12.67 FGF1 FGFR1 FLT3 KDR KIT PDGFRB
11
Show member pathways
12.61 FGF1 FGFR1 FLT3 KDR KIT PDGFRB
12 12.58 BCR FGF1 FGFR1 FLT3 KIT PDGFRB
13
Show member pathways
12.35 FGFR1 KDR PDGFRB TRIM24
14
Show member pathways
12.31 FGF1 FGFR1 FLT3 KDR KIT PDGFRB
15
Show member pathways
12.17 FGF1 FGFR1 KDR KIT PDGFRB
16
Show member pathways
12.13 FGFR1 FGFR1OP FGFR1OP2 KDR
17 11.91 KDR PDGFRB RUNX1
18 11.87 BCR FGF1 FGFR1 FLT3 KDR KIT
19
Show member pathways
11.81 BCR CNTRL FGF1 FGFR1 FGFR1OP FGFR1OP2
20 11.76 FGF1 FGFR1 KDR PDGFRB
21
Show member pathways
11.69 FGFR1 FLT3 KDR KIT PDGFRB
22
Show member pathways
11.66 BCR KDR KIT PDGFRB
23 11.57 FGFR1 FLT3 KIT PDGFRB
24 11.33 FGF1 FGFR1 KDR PDGFRB
25
Show member pathways
11.23 BCR CNTRL FGF1 FGFR1 FGFR1OP FGFR1OP2
26 10.96 FGF1 FGFR1 KDR
27 10.93 FGF1 FGFR1 FLT3 KDR KIT PDGFRB

GO Terms for 8p11 Myeloproliferative Syndrome

Cellular components related to 8p11 Myeloproliferative Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytosol GO:0005829 9.9 BCR CNTRL FGF1 FGFR1 FGFR1OP FGFR1OP2
2 cytoplasm GO:0005737 9.8 BCR CNTRL FGF1 FGFR1 FGFR1OP FGFR1OP2
3 receptor complex GO:0043235 9.02 FGFR1 FLT3 KDR KIT PDGFRB

Biological processes related to 8p11 Myeloproliferative Syndrome according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.95 FGF1 FGFR1 FGFR1OP FLT3 KDR KIT
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 FGFR1 FLT3 KDR KIT PDGFRB
3 positive regulation of cell migration GO:0030335 9.89 FGF1 FGFR1OP KDR KIT PDGFRB
4 positive regulation of protein kinase B signaling GO:0051897 9.88 FGF1 FGFR1 KIT PDGFRB
5 MAPK cascade GO:0000165 9.88 FGF1 FGFR1 FLT3 KIT PDGFRB
6 phosphatidylinositol phosphorylation GO:0046854 9.84 FGF1 FGFR1 KIT PDGFRB
7 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.83 FLT3 KDR KIT PDGFRB
8 positive regulation of angiogenesis GO:0045766 9.8 FGF1 KDR RUNX1
9 hemopoiesis GO:0030097 9.77 FLT3 KIT RUNX1
10 positive regulation of MAPK cascade GO:0043410 9.77 FGFR1 FLT3 KDR KIT PDGFRB
11 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.76 FGF1 FGFR1 FLT3
12 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.72 FLT3 KIT PDGFRB
13 negative regulation of signal transduction GO:0009968 9.72 FGFR1 FLT3 KDR KIT PDGFRB
14 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.65 FGFR1 FLT3 KDR KIT PDGFRB
15 embryonic hemopoiesis GO:0035162 9.62 KDR KIT
16 vascular endothelial growth factor signaling pathway GO:0038084 9.62 FLT3 KDR
17 organ induction GO:0001759 9.61 FGF1 FGFR1
18 positive regulation of phospholipase C activity GO:0010863 9.61 FGFR1 KIT PDGFRB
19 myeloid progenitor cell differentiation GO:0002318 9.59 FLT3 KIT
20 positive regulation of MAP kinase activity GO:0043406 9.55 FGF1 FGFR1 FLT3 KIT PDGFRB
21 protein autophosphorylation GO:0046777 9.5 BCR FGFR1 FLT3 KDR KIT PDGFRB
22 peptidyl-tyrosine phosphorylation GO:0018108 9.4 BCR CNTRL FGF1 FGFR1 FGFR1OP FGFR1OP2
23 cell differentiation GO:0030154 10.08 FGF1 FGFR1 FLT3 KDR KIT PDGFRB
24 phosphorylation GO:0016310 10.04 BCR FGFR1 FLT3 KDR KIT PDGFRB
25 negative regulation of apoptotic process GO:0043066 10.03 FGFR1 FLT3 KDR KIT MYO18A PDGFRB
26 protein phosphorylation GO:0006468 10 BCR FGFR1 FLT3 KDR KIT PDGFRB

Molecular functions related to 8p11 Myeloproliferative Syndrome according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.93 BCR FGFR1 FLT3 KDR KIT PDGFRB
2 nucleotide binding GO:0000166 9.91 FGFR1 FLT3 KIT MYO18A PDGFRB
3 protein kinase activity GO:0004672 9.85 FGFR1 FLT3 KDR KIT PDGFRB TRIM24
4 transmembrane signaling receptor activity GO:0004888 9.72 FGFR1 FLT3 KDR KIT PDGFRB
5 1-phosphatidylinositol-3-kinase activity GO:0016303 9.65 FGF1 FGFR1 FLT3
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.56 FGF1 FGFR1 KIT PDGFRB
7 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.55 FGF1 FGFR1 FLT3 KIT PDGFRB
8 vascular endothelial growth factor-activated receptor activity GO:0005021 9.52 FLT3 KDR
9 vascular endothelial growth factor binding GO:0038085 9.49 KDR PDGFRB
10 protein tyrosine kinase activity GO:0004713 9.4 BCR CNTRL FGF1 FGFR1 FGFR1OP FGFR1OP2
11 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.35 FGFR1 FLT3 KDR KIT PDGFRB
12 protein binding GO:0005515 10.31 BCR CNTRL FGF1 FGFR1 FGFR1OP FGFR1OP2
13 transferase activity GO:0016740 10.09 BCR FGFR1 FLT3 KDR KIT PDGFRB
14 ATP binding GO:0005524 10.03 BCR FGFR1 FLT3 KDR KIT MYO18A
15 protein homodimerization activity GO:0042803 10.01 FGFR1 FGFR1OP FGFR1OP2 FLT3 KIT TPR

Sources for 8p11 Myeloproliferative Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....