MCID: CNN005
MIFTS: 68

Connective Tissue Disease

Categories: Bone diseases, Cancer diseases, Muscle diseases, Skin diseases

Aliases & Classifications for Connective Tissue Disease

MalaCards integrated aliases for Connective Tissue Disease:

Name: Connective Tissue Disease 12 6 15 17
Connective Tissue Diseases 54 43 71
Abnormality of Connective Tissue 29 6
Disorder of Connective Tissue 12
Connective Tissue Disorders 42
Connective Tissue Disorder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:65
MeSH 43 D003240
NCIt 49 C26729
SNOMED-CT 67 105969002
UMLS 71 C0009782

Summaries for Connective Tissue Disease

MedlinePlus : 42 Your connective tissue supports many different parts of your body, such as your skin, eyes, and heart. It is like a "cellular glue" that gives your body parts their shape and helps keep them strong. It also helps some of your tissues do their work. It is made of many kinds of proteins. Cartilage and fat are types of connective tissue. Over 200 disorders that impact connective tissue. There are different types: Genetic disorders, such as Ehlers-Danlos syndrome, Marfan syndrome, and osteogenesis imperfecta Autoimmune disorders, such as lupus and scleroderma Cancers, like some types of soft tissue sarcoma Each disorder has its own symptoms and needs different treatment. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

MalaCards based summary : Connective Tissue Disease, also known as connective tissue diseases, is related to mixed connective tissue disease and collagen disease, and has symptoms including back pain, sciatica and muscle cramp. An important gene associated with Connective Tissue Disease is FBN1 (Fibrillin 1), and among its related pathways/superpathways are Integrin Pathway and ERK Signaling. The drugs Pirfenidone and Budesonide have been mentioned in the context of this disorder. Affiliated tissues include lung, skin and testes, and related phenotypes are cardiovascular system and cellular

Disease Ontology : 12 A musculoskeletal system disease that affects tissues such as skin, tendons, and cartilage.

Wikipedia : 74 A connective tissue disease (collagenosis) is any disease that has the connective tissues of the body as... more...

Related Diseases for Connective Tissue Disease

Diseases related to Connective Tissue Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(showing 1158, show less)
# Related Disease Score Top Affiliating Genes
1 mixed connective tissue disease 36.1 TNF RNPC3 IL6 BMPR2 ADAMTS13
2 collagen disease 34.4 TGFBR2 FBN1 COL5A1 COL3A1 COL2A1 COL1A2
3 marfan syndrome 34.1 TGFBR2 NOTCH1 LOX FLNA FBN2 FBN1
4 aortic aneurysm, familial thoracic 1 34.1 TGFBR2 SMAD3 NOTCH1 LOX FBN2 FBN1
5 scleroderma, familial progressive 33.6 FBN1 COL1A2 COL1A1 CENPB
6 bone disease 33.5 TNF IL6 FLNA COL2A1 COL1A1
7 weill-marchesani syndrome 33.2 TNF FBN2 FBN1 ADAMTS13
8 arterial tortuosity syndrome 33.1 TGFBR2 SMAD3 FBN1 COL3A1 ACTA2
9 systemic scleroderma 33.0 TNF IL6 FBN1 COL1A2 CENPB
10 pulmonary hypertension 32.8 TNF TGFBR2 SMAD3 IL6 EDNRA BMPR2
11 ehlers-danlos syndrome, arthrochalasia type, 2 32.8 COL1A2 COL1A1
12 pulmonary fibrosis, idiopathic 32.5 TNF SMAD3 LOX IL6 COL3A1 COL1A2
13 hypermobility syndrome 32.5 FBN1 COL5A1 COL3A1
14 ehlers-danlos syndrome 32.2 FLNA FBN2 FBN1 COL5A1 COL3A1 COL1A2
15 aortic aneurysm 32.0 TGFBR2 SMAD3 NOTCH1 LOX IL6 FLNA
16 purpura 32.0 TNF IL6 ADAMTS13
17 orthostatic intolerance 32.0 TGFBR2 SMAD3 FLNA FBN2 FBN1 COL5A1
18 localized scleroderma 32.0 TNF SMAD3 IL6 COL1A1
19 aneurysm 31.9 TGFBR2 SMAD3 NOTCH1 LOX FBN2 FBN1
20 osteoporosis 31.9 TNF SMAD3 LOX IL6 COL2A1 COL1A2
21 brittle bone disorder 31.9 FBN1 COL5A1 COL3A1 COL2A1 COL1A2 COL1A1
22 aortic valve disease 1 31.8 TGFBR2 SMAD3 NOTCH1 LOX FLNA FBN2
23 telangiectasis 31.8 FBN1 CENPB BMPR2
24 portal hypertension 31.8 TNF EDNRA BMPR2 ADAMTS13
25 calcinosis 31.8 TNF FBN1 CENPB
26 inguinal hernia 31.7 LOX IL6 FBN1 COL5A1 COL1A1
27 diffuse scleroderma 31.7 COL1A2 COL1A1 CENPB
28 loeys-dietz syndrome 31.7 TGFBR2 SMAD3 FBN2 FBN1 COL5A1 COL3A1
29 aortic disease 31.7 TGFBR2 SMAD3 NOTCH1 LOX IL6 FBN1
30 caffey disease 31.6 COL2A1 COL1A2 COL1A1
31 limited scleroderma 31.5 RNPC3 EDNRA CENPB
32 scoliosis 31.5 TGFBR2 LOX IL6 FLNA FBN2 FBN1
33 heart disease 31.5 TNF NOTCH1 IL6 FLNA FBN1 EDNRA
34 carpal tunnel syndrome 31.4 IL6 COL5A1 COL1A1
35 aortic dissection 31.4 TGFBR2 SMAD3 LOX FBN1 COL3A1 ACTA2
36 varicose veins 31.4 TNF IL6 FBN1 COL3A1
37 tricuspid valve prolapse 31.3 TGFBR2 SMAD3 FBN2 FBN1 COL3A1
38 odontochondrodysplasia 31.3 FLNA FBN1 COL5A1 COL3A1 COL2A1 COL1A2
39 retinal detachment 31.3 TNF LOX IL6 COL2A1
40 placenta disease 31.3 TNF IL6 COL3A1
41 osteoarthritis 31.3 TNF SMAD3 IL6 COL2A1
42 ehlers-danlos syndrome, classic type, 1 31.3 COL5A1 COL3A1 COL1A2 COL1A1
43 leprosy 3 31.2 TNF IL6 FLNA
44 disseminated intravascular coagulation 31.2 TNF IL6 ADAMTS13
45 heritable thoracic aortic disease 31.2 TGFBR2 SMAD3 LOX FBN1 COL3A1 ACTA2
46 aortic valve insufficiency 31.2 TGFBR2 FBN1 ACTA2
47 pelvic organ prolapse 31.1 LOX FBN1 COL3A1 COL1A2 COL1A1
48 cerebrovascular disease 31.1 TNF IL6 ADAMTS13 ACTA2
49 keratoconus 31.1 TNF LOX IL6 FBN1 COL5A1
50 myopia 31.0 FLNA FBN2 FBN1 COL2A1 COL1A1
51 stickler syndrome 31.0 FBN1 COL2A1 COL1A2 COL1A1
52 stroke, ischemic 31.0 TNF IL6 FBN1 EDNRA ADAMTS13
53 lymphoid interstitial pneumonia 31.0 TNF IL6 FBN1
54 loeys-dietz syndrome 5 31.0 TGFBR2 SMAD3 FBN1
55 bone resorption disease 31.0 TNF IL6 COL1A2 COL1A1
56 arteriovenous malformation 31.0 TNF TGFBR2 IL6 BMPR2
57 classic ehlers-danlos syndrome 31.0 COL5A1 COL1A2 COL1A1
58 arteriosclerosis 30.9 LOX IL6 FBN1 EDNRA
59 spinal stenosis 30.9 COL2A1 COL1A2 COL1A1
60 osteogenesis imperfecta, type ii 30.9 COL5A1 COL1A2 COL1A1
61 ehlers-danlos syndrome, classic type, 2 30.7 COL5A1 COL3A1
62 undifferentiated connective tissue disease 12.8
63 pulmonary arterial hypertension associated with connective tissue disease 12.6
64 secondary interstitial lung disease in childhood and adulthood associated with a connective tissue disease 12.6
65 overlapping connective tissue disease 12.6
66 secondary interstitial lung disease specific to childhood associated with a connective tissue disease 12.5
67 emilin-1-related connective tissue disease 12.4
68 bone fragility with contractures, arterial rupture, and deafness 12.2
69 mccune-albright syndrome 12.1
70 pulmonary hypertension, primary, 1 11.5
71 fibrodysplasia ossificans progressiva 11.5
72 marden-walker syndrome 11.4
73 pulmonary fibrosis 11.4
74 ehlers-danlos syndrome, dermatosparaxis type 11.4
75 occipital horn syndrome 11.4
76 osteogenesis imperfecta, type xii 11.4
77 crest syndrome 11.4
78 enthesopathy 11.4
79 synovitis 11.4
80 raynaud disease 11.3
81 fasciitis 11.3
82 scleritis 11.3
83 rheumatic fever 11.3
84 pseudoxanthoma elasticum 11.3
85 ehlers-danlos syndrome, hypermobility type 11.3
86 loeys-dietz syndrome 2 11.3
87 winchester syndrome 11.3
88 mucinoses 11.3
89 mediastinitis 11.3
90 lipodermatosclerosis 11.3
91 systemic onset juvenile idiopathic arthritis 11.3
92 hajdu-cheney syndrome 11.3
93 coronary artery dissection, spontaneous 11.3
94 lateral meningocele syndrome 11.3
95 cutis laxa, autosomal recessive, type ia 11.3
96 ehlers-danlos syndrome, spondylodysplastic type, 3 11.3
97 brittle cornea syndrome 2 11.3
98 ehlers-danlos syndrome, spondylodysplastic type, 2 11.3
99 gastroparesis 11.3
100 polymyositis 11.2
101 familial thoracic aortic aneurysm and aortic dissection 11.2 TGFBR2 SMAD3 NOTCH1 LOX FBN2 FBN1
102 ehlers-danlos syndrome, vascular type 11.2
103 ehlers-danlos syndrome, kyphoscoliotic type, 1 11.2
104 systemic lupus erythematosus 11.2
105 bone structure disease 11.2 TNF IL6 FBN2 FBN1 COL2A1 COL1A2
106 intracranial aneurysm 11.2 TNF TGFBR2 LOX FBN2 EDNRA COL3A1
107 hypertension, essential 11.1 TNF SMAD3 LOX IL6 FLNA FBN1
108 cutis laxa, autosomal dominant 1 11.1
109 ehlers-danlos syndrome, periodontal type, 1 11.1
110 osteogenesis imperfecta, type ix 11.1
111 weill-marchesani syndrome 1 11.1
112 ehlers-danlos syndrome, classic-like 11.1
113 weill-marchesani syndrome 2 11.1
114 osteogenesis imperfecta, type vii 11.1
115 osteogenesis imperfecta, type viii 11.1
116 osteogenesis imperfecta, type v 11.1
117 osteogenesis imperfecta, type xi 11.1
118 osteogenesis imperfecta, type x 11.1
119 osteogenesis imperfecta, type vi 11.1
120 cutis laxa, autosomal dominant 2 11.1
121 weill-marchesani syndrome 3 11.1
122 osteogenesis imperfecta, type xiii 11.1
123 osteogenesis imperfecta, type xiv 11.1
124 osteogenesis imperfecta, type xv 11.1
125 kyphoscoliotic ehlers-danlos syndrome 11.1
126 aortic aneurysm, familial thoracic 2 11.1 FLNA FBN2 FBN1 COL3A1 ACTA2
127 patent ductus arteriosus 1 11.1 TGFBR2 NOTCH1 FLNA FBN1 ACTA2
128 cataract 11.0 TNF TGFBR2 IL6 FBN1 COL5A1 COL2A1
129 loeys-dietz syndrome 3 11.0 TGFBR2 SMAD3 FBN1 ACTA2
130 loeys-dietz syndrome 1 11.0 TGFBR2 SMAD3 FBN1 ACTA2
131 bone development disease 11.0 FBN1 COL2A1 COL1A2 COL1A1
132 oral submucous fibrosis 11.0 TNF LOX FLNA COL1A1
133 ischemic bone disease 11.0 TNF IL6 COL2A1 COL1A1
134 williams-beuren syndrome 11.0
135 cerebral arterial disease 11.0 IL6 EDNRA COL3A1 ACTA2
136 bone remodeling disease 11.0 TNF IL6 COL1A2 COL1A1
137 systemic lupus erythematosus 11 11.0
138 bethlem myopathy 2 11.0
139 larsen-like syndrome 11.0 COL3A1 COL1A2 COL1A1
140 sjogren syndrome 11.0
141 ainhum 11.0
142 vertical talus, congenital 11.0
143 hyaline fibromatosis syndrome 11.0
144 ossification of the posterior longitudinal ligament of spine 11.0
145 funisitis 11.0
146 episcleritis periodica fugax 11.0
147 scleroperikeratitis 11.0
148 frozen shoulder 11.0
149 ochronosis 11.0
150 brawny scleritis 11.0
151 sclerosing keratitis 11.0
152 volkmann contracture 11.0
153 plantar fascial fibromatosis 11.0
154 interstitial keratitis 11.0
155 periostitis 11.0
156 mounier-kuhn syndrome 11.0
157 necrotizing autoimmune myopathy 11.0
158 periodontal ehlers-danlos syndrome 11.0
159 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 11.0 TNF IL6 FBN1 COL2A1
160 tympanosclerosis 11.0 TNF COL2A1 COL1A1
161 ehlers-danlos syndrome, arthrochalasia type, 1 11.0
162 ehlers-danlos syndrome, spondylodysplastic type, 1 11.0
163 myhre syndrome 11.0
164 buschke-ollendorff syndrome 11.0
165 peyronie disease 11.0
166 ehlers-danlos syndrome, cardiac valvular type 11.0
167 geroderma osteodysplasticum 11.0
168 osteogenesis imperfecta, type xix 11.0
169 ehlers-danlos syndrome, musculocontractural type, 1 11.0
170 weill-marchesani syndrome 4 11.0
171 cutis laxa, autosomal recessive, type ib 11.0
172 ehlers-danlos syndrome, kyphoscoliotic type, 2 11.0
173 osteogenesis imperfecta, type xvi 11.0
174 osteogenesis imperfecta, type xvii 11.0
175 cutis laxa, autosomal dominant 3 11.0
176 ehlers-danlos syndrome, periodontal type, 2 11.0
177 osteogenesis imperfecta, type xviii 11.0
178 ehlers-danlos syndrome, classic-like, 2 11.0
179 osteogenesis imperfecta, type xx 11.0
180 ehlers-danlos syndrome progeroid type 11.0
181 autosomal recessive cutis laxa type i 11.0
182 arthrochalasia ehlers-danlos syndrome 11.0
183 musculocontractural ehlers-danlos syndrome 11.0
184 loeys-dietz syndrome 4 11.0 TGFBR2 SMAD3 FBN1
185 stiff skin syndrome 11.0 FBN2 FBN1 COL1A2
186 neurotic disorder 11.0 TNF IL6 FLNA
187 vaginal discharge 11.0 TNF IL6 FLNA
188 suppression of tumorigenicity 12 11.0 TNF TGFBR2 NOTCH1 IL6
189 cervicitis 11.0 TNF IL6 FLNA
190 idiopathic scoliosis 10.9 FBN2 FBN1 COL1A2
191 chronic pulmonary heart disease 10.9 TNF EDNRA BMPR2
192 vitreous disease 10.9 TNF IL6 COL2A1
193 bone deterioration disease 10.9 TNF IL6 COL2A1
194 autoimmune disease of cardiovascular system 10.9 TNF IL6 ADAMTS13
195 ureteral disease 10.9 TNF SMAD3 IL6
196 juvenile rheumatoid arthritis 10.9
197 autoimmune disease of blood 10.9 TNF IL6 ADAMTS13
198 hepatopulmonary syndrome 10.9 TNF EDNRA BMPR2
199 ehlers-danlos/osteogenesis imperfecta syndrome 10.9 COL1A2 COL1A1
200 col1a1/2 osteogenesis imperfecta 10.9 COL1A2 COL1A1
201 preterm premature rupture of the membranes 10.9 TNF IL6 COL5A1
202 hepatic vascular disease 10.9 TNF IL6 BMPR2
203 neonatal jaundice 10.9 TNF IL6 ADAMTS13
204 orofacial cleft 10.9 TGFBR2 SMAD3 FBN1 COL2A1
205 external pathological resorption 10.9 TNF IL6
206 scorpion envenomation 10.9 TNF IL6
207 commensal bacterial infectious disease 10.9 TNF IL6 EDNRA
208 high bone mass osteogenesis imperfecta 10.9 COL1A2 COL1A1
209 intestinal obstruction 10.9 TNF IL6 FLNA
210 raynaud phenomenon 10.9
211 coronary stenosis 10.9 IL6 COL3A1 ADAMTS13
212 lung disease 10.9
213 dermatomyositis 10.9
214 familial abdominal aortic aneurysm 10.9 FBN1 COL3A1
215 idiopathic anterior uveitis 10.9 TNF IL6
216 migraine without aura 10.9 TNF TGFBR2 EDNRA
217 interstitial lung disease 10.9
218 polyarteritis nodosa 10.9
219 streptococcal toxic-shock syndrome 10.9 TNF IL6
220 bullous impetigo 10.9 IL6 EDNRA
221 angioimmunoblastic lymphadenopathy with dysproteinemia 10.9 TNF IL6
222 type i ehlers-danlos syndrome 10.8 COL1A2 COL1A1
223 lens disease 10.8 TNF IL6 FBN1
224 kashin-beck disease 10.8 TNF COL2A1
225 endosteal hyperostosis, autosomal dominant 10.8 NOTCH1 COL1A2 COL1A1
226 pancreatic adenocarcinoma 10.8 TNF TGFBR2 SMAD3 NOTCH1 IL6
227 blood coagulation disease 10.8 TNF IL6 ADAMTS13
228 lipoblastoma 10.8 COL3A1 COL1A2
229 alcoholic hepatitis 10.8 TNF IL6 ADAMTS13
230 microscopic polyangiitis 10.8
231 ureteric orifice cancer 10.8 LOX FBN1
232 osteonecrosis 10.8
233 childhood type dermatomyositis 10.8
234 keloid formation 10.8 IL6 FLNA
235 autoimmune disease 10.8
236 vasculitis 10.7
237 temporal arteritis 10.7
238 granulomatosis with polyangiitis 10.7
239 potocki-shaffer syndrome 10.7 TNF IL6 CENPB
240 intracranial berry aneurysm 10.7 TNF IL6 EDNRA
241 takayasu arteritis 10.7
242 relapsing polychondritis 10.7
243 churg-strauss syndrome 10.7
244 myositis 10.7
245 radiation proctitis 10.7 TNF EDNRA
246 pectus carinatum 10.6 FBN1 COL2A1
247 adult-onset still's disease 10.6
248 kawasaki disease 10.6
249 lupus erythematosus 10.6
250 nontuberculous mycobacterial lung disease 10.6 TNF FBN1
251 null-cell leukemia 10.5 TNF IL6
252 behcet syndrome 10.5
253 reactive arthritis 10.5
254 osteochondrosis 10.5
255 hypersensitivity vasculitis 10.5
256 antiphospholipid syndrome 10.5
257 myopathy 10.5
258 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.5
259 vascular disease 10.5
260 anaerobic pneumonia 10.5 TNF IL6
261 thrombocytopenia 10.4
262 pneumonia 10.4
263 neuropathy 10.4
264 inflammatory spondylopathy 10.4
265 glomerulonephritis 10.4
266 spondylitis 10.4
267 pediatric systemic lupus erythematosus 10.4
268 nonspecific interstitial pneumonia 10.4
269 spondyloarthropathy 1 10.4
270 rheumatoid arthritis 10.4
271 pericarditis 10.4
272 idiopathic interstitial pneumonia 10.4
273 myocarditis 10.4
274 hemopericardium 10.4
275 pericardial effusion 10.4
276 blood platelet disease 10.4 TNF IL6 ADAMTS13
277 respiratory failure 10.3
278 sarcoidosis 1 10.3
279 thrombotic thrombocytopenic purpura 10.3
280 exanthem 10.3
281 thyroiditis 10.3
282 systemic autoimmune disease 10.3
283 heart block, congenital 10.3
284 primary biliary cirrhosis 10.3
285 autoimmune hepatitis 10.3
286 fibrosis of extraocular muscles, congenital, 1 10.3
287 plica syndrome 10.3
288 collagenoma, familial cutaneous 10.3
289 nephrotic syndrome 10.3
290 neutropenia 10.3
291 meningitis 10.3
292 pre-eclampsia 10.2
293 aseptic meningitis 10.2
294 arthropathy 10.2
295 hemolytic anemia 10.2
296 dysphagia 10.2
297 hypothyroidism 10.2
298 psoriatic arthritis 10.2
299 keratoconjunctivitis sicca 10.2
300 lymphopenia 10.2
301 juvenile arthritis 10.2
302 panniculitis 10.2
303 myelitis 10.2
304 arthritis 10.2
305 cardiac tamponade 10.2
306 allergic hypersensitivity disease 10.2
307 peripheral nervous system disease 10.2
308 fibromyalgia 10.2
309 alopecia 10.2
310 anca-associated vasculitis 10.2
311 discoid lupus erythematosus 10.2
312 bone mineral density quantitative trait locus 8 10.2
313 bone mineral density quantitative trait locus 15 10.2
314 cutaneous lupus erythematosus 10.2
315 pneumocystosis 10.2
316 polyneuropathy 10.2
317 sensory peripheral neuropathy 10.2
318 hypereosinophilic syndrome 10.2
319 47,xyy 10.2
320 membranous nephropathy 10.1
321 rickets 10.1
322 spondyloarthropathy 10.1
323 bronchiolitis 10.1
324 syphilis 10.1
325 amyloidosis 10.1
326 keratoconjunctivitis 10.1
327 transverse myelitis 10.1
328 calvarial doughnut lesions with bone fragility 10.1
329 hyperostosis cranialis interna 10.1
330 hyperostosis frontalis interna 10.1
331 melorheostosis, isolated 10.1
332 osseous heteroplasia, progressive 10.1
333 arthrogryposis, distal, type 10 10.1
334 craniodiaphyseal dysplasia 10.1
335 goodpasture syndrome 10.1
336 van buchem disease 10.1
337 muscular dystrophy, congenital, producing arthrogryposis 10.1
338 sclerosteosis 1 10.1
339 thrombotic thrombocytopenic purpura, hereditary 10.1
340 bone mineral density quantitative trait locus 18 10.1
341 calvarial hyperostosis 10.1
342 aneurysmal bone cysts 10.1
343 sclerosteosis 2 10.1
344 vasculitis, autoinflammation, immunodeficiency, and hematologic defects syndrome 10.1
345 sting-associated vasculopathy, infantile-onset 10.1
346 autoimmune disease, multisystem, infantile-onset, 1 10.1
347 sclerosteosis 10.1
348 fibrous dysplasia 10.1
349 de quervain disease 10.1
350 calcific tendinitis 10.1
351 lethal midline granuloma 10.1
352 myositis fibrosa 10.1
353 condensing osteitis of the clavicle 10.1
354 infective myositis 10.1
355 juvenile polymyositis 10.1
356 macrophagic myofasciitis 10.1
357 melorheostosis with osteopoikilosis 10.1
358 oncogenic osteomalacia 10.1
359 isolated sternocostoclavicular hyperostosis 10.1
360 idiopathic eosinophilic myositis 10.1
361 unclassified vasculitis 10.1
362 drug-induced vasculitis 10.1
363 parasitic myositis 10.1
364 bacterial myositis 10.1
365 fungal myositis 10.1
366 viral myositis 10.1
367 infectious, fungal or parasitic myopathy 10.1
368 myalgia-eosinophilia syndrome associated with tryptophan 10.1
369 juvenile overlap myositis 10.1
370 mixed sclerosing bone dystrophy with extra-skeletal manifestations 10.1
371 tafro syndrome 10.1
372 neonatal dermatomyositis 10.1
373 systemic polyarteritis nodosa 10.1
374 secondary polyarteritis nodosa 10.1
375 single-organ polyarteritis nodosa 10.1
376 primary polyarteritis nodosa 10.1
377 mazabraud syndrome 10.1
378 monostotic fibrous dysplasia 10.1
379 cytophagic histiocytic panniculitis 10.1
380 pancytopenia 10.1
381 acute kidney failure 10.1
382 skin disease 10.1
383 liver disease 10.1
384 proliferative glomerulonephritis 10.1
385 liver cirrhosis 10.1
386 bronchiectasis 10.1
387 felty syndrome 10.1
388 patella, chondromalacia of 10.1
389 scheuermann disease 10.1
390 tumoral calcinosis, hyperphosphatemic, familial, 1 10.1
391 chronic recurrent multifocal osteomyelitis 10.1
392 osteoporosis, juvenile 10.1
393 drug-induced lupus erythematosus 10.1
394 bruck syndrome 10.1
395 primary hypertrophic osteoarthropathy 10.1
396 nodular nonsuppurative panniculitis 10.1
397 pigmented villonodular synovitis 10.1
398 osteochondritis dissecans 10.1
399 pyomyositis 10.1
400 intermittent hydrarthrosis 10.1
401 solitary bone cyst 10.1
402 hashimoto thyroiditis 10.1
403 thrombophilia due to thrombin defect 10.1
404 myasthenia gravis 10.1
405 protein-losing enteropathy 10.1
406 gout 10.1
407 kidney disease 10.1
408 banti's syndrome 10.1
409 cytokine deficiency 10.1
410 atherosclerosis susceptibility 10.1
411 gastroesophageal reflux 10.1
412 trigeminal neuralgia 10.1
413 systemic lupus erythematosus 1 10.1
414 esophagitis 10.1
415 crescentic glomerulonephritis 10.1
416 uveitis 10.1
417 pneumatosis cystoides intestinalis 10.1
418 eclampsia 10.1
419 lymphadenitis 10.1
420 neuromyelitis optica 10.1
421 pulmonary embolism 10.1
422 polycystic kidney disease 10.0
423 anemia, autoimmune hemolytic 10.0
424 celiac disease 1 10.0
425 eosinophilic fasciitis 10.0
426 anemia, x-linked, with or without neutropenia and/or platelet abnormalities 10.0
427 deficiency anemia 10.0
428 atrioventricular block 10.0
429 cardiac arrest 10.0
430 sialadenitis 10.0
431 retinal vasculitis 10.0
432 neuritis 10.0
433 agammaglobulinemia 10.0
434 tricuspid valve insufficiency 10.0
435 pustulosis of palm and sole 10.0
436 rapidly progressive glomerulonephritis 10.0
437 immune-complex glomerulonephritis 10.0
438 septic arthritis 10.0
439 psoriasis 10.0
440 splenomegaly 10.0
441 spondylarthropathy 10.0
442 diffuse alveolar hemorrhage 10.0
443 acroosteolysis 10.0
444 progressive familial heart block, type ia 10.0
445 multiple sclerosis 10.0
446 familial mediterranean fever 10.0
447 systemic lupus erythematosus 12 10.0
448 hyperprolactinemia 10.0
449 aspiration pneumonia 10.0
450 cryptogenic organizing pneumonia 10.0
451 inflammatory bowel disease 10.0
452 immunoglobulin alpha deficiency 10.0
453 intestinal pseudo-obstruction 10.0
454 hypogonadotropic hypogonadism 10.0
455 xerophthalmia 10.0
456 silicosis 10.0
457 malignant hypertension 10.0
458 brucellosis 10.0
459 optic neuritis 10.0
460 dilated cardiomyopathy 10.0
461 diarrhea 10.0
462 pneumothorax 10.0
463 viral hepatitis 10.0
464 hepatitis b 10.0
465 acute pancreatitis 10.0
466 hyperglycemia 10.0
467 mesangial proliferative glomerulonephritis 10.0
468 pancreatitis 10.0
469 pulmonary venoocclusive disease 10.0
470 congestive heart failure 10.0
471 paraplegia 10.0
472 hyperthyroidism 10.0
473 peritonitis 10.0
474 extrinsic allergic alveolitis 10.0
475 herpes zoster 10.0
476 chickenpox 10.0
477 neurofibromatosis 10.0
478 pemphigus 10.0
479 tenosynovitis 10.0
480 allergic angiitis 10.0
481 hansen's disease 10.0
482 nodular regenerative hyperplasia 10.0
483 encephalopathy 10.0
484 subacute cutaneous lupus erythematosus 10.0
485 thrombotic microangiopathy 10.0
486 osteopoikilosis 10.0
487 mammary paget's disease 10.0
488 paget's disease of bone 10.0
489 cryoglobulinemia, familial mixed 9.9
490 autosomal dominant polycystic kidney disease 9.9
491 type ii mixed cryoglobulinemia 9.9
492 lichen sclerosus et atrophicus 9.9
493 thrombocytopenic purpura, autoimmune 9.9
494 chondrodysplasia punctata syndrome 9.9
495 immune deficiency disease 9.9
496 proteasome-associated autoinflammatory syndrome 1 9.9
497 pulmonary venoocclusive disease 1, autosomal dominant 9.9
498 budd-chiari syndrome 9.9
499 yemenite deaf-blind hypopigmentation syndrome 9.9
500 coronary heart disease 1 9.9
501 systemic lupus erythematosus 4 9.9
502 human immunodeficiency virus type 1 9.9
503 myelodysplastic syndrome 9.9
504 gastrointestinal ulceration, recurrent, with dysfunctional platelets 9.9
505 thrombosis 9.9
506 cryptococcal meningitis 9.9
507 hepatic veno-occlusive disease 9.9
508 castleman disease 9.9
509 pleurisy 9.9
510 bacterial infectious disease 9.9
511 interstitial nephritis 9.9
512 esophageal varix 9.9
513 tetanus 9.9
514 pulmonary edema 9.9
515 lyme disease 9.9
516 mononeuropathy 9.9
517 goiter 9.9
518 hepatitis a 9.9
519 hepatic coma 9.9
520 facial paralysis 9.9
521 renal tubular acidosis 9.9
522 thrombocytopenia due to platelet alloimmunization 9.9
523 cystitis 9.9
524 mononeuritis multiplex 9.9
525 optic nerve disease 9.9
526 hepatitis 9.9
527 nocardiosis 9.9
528 bronchiolitis obliterans 9.9
529 ischemia 9.9
530 central nervous system disease 9.9
531 thyroid gland disease 9.9
532 t-cell lymphoblastic leukemia/lymphoma 9.9
533 measles 9.9
534 nervous system disease 9.9
535 sickle cell disease 9.9
536 antisynthetase syndrome 9.9
537 fibrosing mediastinitis 9.9
538 leukemia, t-cell, chronic 9.9
539 pleuroparenchymal fibroelastosis 9.9
540 retroperitoneal fibrosis 9.9
541 rheumatoid vasculitis 9.9
542 back pain 9.9
543 headache 9.9
544 neonatal lupus erythematosus 9.9
545 acute liver failure 9.9
546 mucopolysaccharidosis, type ii 9.9
547 hurler syndrome 9.9
548 aortic aneurysm, familial abdominal, 1 9.8
549 hypertelorism 9.8
550 pneumothorax, primary spontaneous 9.8
551 shprintzen-goldberg craniosynostosis syndrome 9.8
552 brittle cornea syndrome 1 9.8
553 spondyloepimetaphyseal dysplasia with joint laxity, type 1, with or without fractures 9.8
554 spondyloepimetaphyseal dysplasia, matrilin-3 related 9.8
555 alacrima, achalasia, and mental retardation syndrome 9.8
556 helix syndrome 9.8
557 frontometaphyseal dysplasia 9.8
558 meningocele 9.8
559 candidiasis 9.8
560 chronic mucocutaneous candidiasis 9.8
561 cerebritis 9.8
562 intracranial hypotension 9.8
563 epidermolysis bullosa dystrophica 9.8
564 muscular dystrophy 9.8
565 distal renal tubular acidosis 9.8
566 hypotonia 9.8
567 amyotrophic lateral sclerosis 1 9.8
568 atrial standstill 1 9.8
569 contractural arachnodactyly, congenital 9.8
570 ige responsiveness, atopic 9.8
571 migraine with or without aura 1 9.8
572 pemphigus vulgaris, familial 9.8
573 lymphoma, hodgkin, classic 9.8
574 ocular motor apraxia 9.8
575 osteogenesis imperfecta, type iii 9.8
576 thymoma, familial 9.8
577 ataxia and polyneuropathy, adult-onset 9.8
578 malignant atrophic papulosis 9.8
579 macular degeneration, age-related, 1 9.8
580 dermatitis, atopic 9.8
581 ventricular fibrillation, paroxysmal familial, 1 9.8
582 progressive familial heart block, type ib 9.8
583 systemic lupus erythematosus 2 9.8
584 systemic lupus erythematosus 3 9.8
585 pulmonary disease, chronic obstructive 9.8
586 nasopharyngeal carcinoma 9.8
587 mycobacterium tuberculosis 1 9.8
588 kala-azar 1 9.8
589 aplastic anemia 9.8
590 hepatitis c virus 9.8
591 systemic lupus erythematosus 6 9.8
592 graft-versus-host disease 9.8
593 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.8
594 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 9.8
595 encephalopathy, progressive, early-onset, with episodic rhabdomyolysis 9.8
596 livedoid vasculitis 9.8
597 erythema multiforme 9.8
598 adult t-cell leukemia 9.8
599 limb ischemia 9.8
600 aphasia 9.8
601 lymphoma 9.8
602 x-linked chondrodysplasia punctata 1 9.8
603 lymphoproliferative syndrome 9.8
604 covid-19 9.8
605 isolated ectopia lentis 9.8
606 left bundle branch hemiblock 9.8
607 meningoencephalitis 9.8
608 lepromatous leprosy 9.8
609 erysipelas 9.8
610 chondrocalcinosis 9.8
611 listeriosis 9.8
612 palindromic rheumatism 9.8
613 gestational diabetes 9.8
614 graves' disease 9.8
615 hemolytic-uremic syndrome 9.8
616 acute cystitis 9.8
617 right bundle branch block 9.8
618 pure red-cell aplasia 9.8
619 hepatic encephalopathy 9.8
620 poems syndrome 9.8
621 sclerosing cholangitis 9.8
622 reye syndrome 9.8
623 papilledema 9.8
624 pleural disease 9.8
625 urticaria 9.8
626 angioedema 9.8
627 constipation 9.8
628 ankylosis 9.8
629 lateral sclerosis 9.8
630 gastroenteritis 9.8
631 protein s deficiency 9.8
632 thrombophilia 9.8
633 cryoglobulinemia 9.8
634 periarthritis 9.8
635 thymoma 9.8
636 thymic carcinoma 9.8
637 skin carcinoma 9.8
638 gastritis 9.8
639 polyradiculoneuropathy 9.8
640 macular retinal edema 9.8
641 calciphylaxis 9.8
642 chronic inflammatory demyelinating polyradiculoneuropathy 9.8
643 demyelinating polyneuropathy 9.8
644 central nervous system vasculitis 9.8
645 bronchitis 9.8
646 conjunctivitis 9.8
647 muscular atrophy 9.8
648 end stage renal disease 9.8
649 bullous pemphigoid 9.8
650 herpes simplex 9.8
651 myeloid leukemia 9.8
652 bacterial pneumonia 9.8
653 chorioretinitis 9.8
654 leishmaniasis 9.8
655 visceral leishmaniasis 9.8
656 dyskinesia of esophagus 9.8
657 iridocyclitis 9.8
658 cholangitis 9.8
659 irritable bowel syndrome 9.8
660 heritable pulmonary arterial hypertension 9.8
661 hypermobile ehlers-danlos syndrome 9.8
662 48,xyyy 9.8
663 acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) 9.8
664 allergic encephalomyelitis 9.8
665 cutaneous polyarteritis nodosa 9.8
666 erythrokeratoderma ''en cocardes'' 9.8
667 granulocytopenia 9.8
668 heparin-induced thrombocytopenia 9.8
669 human t-cell leukemia virus type 1 9.8
670 linear scleroderma 9.8
671 lymphangiectasis 9.8
672 pemphigus foliaceus 9.8
673 autonomic dysfunction 9.8
674 chronic pain 9.8
675 mucopolysaccharidoses 9.8
676 acute transverse myelitis 9.8
677 combined pulmonary fibrosis-emphysema syndrome 9.8
678 bronchiolitis obliterans with obstructive pulmonary disease 9.8
679 avascular necrosis 9.8
680 secondary vasculitis 9.8
681 erythema multiforme major 9.8
682 pik3ca-related overgrowth syndrome 9.8
683 red cell aplasia 9.8
684 gingival overgrowth 9.7
685 overgrowth syndrome 9.7
686 familial adenomatous polyposis 1 9.7
687 alpha-2-deficient collagen disease 9.7
688 cutis laxa, autosomal recessive, type iia 9.7
689 diastrophic dysplasia 9.7
690 hydrocephalus, tall stature, joint laxity, and kyphoscoliosis 9.7
691 lipoid proteinosis of urbach and wiethe 9.7
692 rheumatic fever-related antigen 9.7
693 wrinkly skin syndrome 9.7
694 scheie syndrome 9.7
695 anxiety 9.7
696 cutis laxa, autosomal recessive, type iic 9.7
697 rheumatic heart disease 9.7
698 hydrocephalus 9.7
699 mucopolysaccharidosis iii 9.7
700 avoidant personality disorder 9.7
701 personality disorder 9.7
702 pharyngitis 9.7
703 mesenchymal cell neoplasm 9.7
704 atp6v0a2-related cutis laxa 9.7
705 plod1-related kyphoscoliotic ehlers-danlos syndrome 9.7
706 skeletal dysplasias 9.7
707 cerebral aneurysms 9.7
708 dysautonomia 9.7
709 intestinal polyposis syndrome 9.7
710 achondroplasia 9.7
711 neurofibromatosis, type ii 9.7
712 arteries, anomalies of 9.7
713 cardiac conduction defect 9.7
714 chiari malformation type i 9.7
715 epicanthus 9.7
716 developmental dysplasia of the hip 1 9.7
717 hpa i recognition polymorphism, beta-globin-related 9.7
718 spondyloepiphyseal dysplasia with congenital joint dislocations 9.7
719 attention deficit-hyperactivity disorder 9.7
720 keratitis, hereditary 9.7
721 cardiospondylocarpofacial syndrome 9.7
722 arthrogryposis, distal, type 7 9.7
723 parkinson disease, late-onset 9.7
724 hypokalemic periodic paralysis, type 1 9.7
725 polycystic kidney disease 1 with or without polycystic liver disease 9.7
726 pseudoachondroplasia 9.7
727 chromosome 2q35 duplication syndrome 9.7
728 down syndrome 9.7
729 von hippel-lindau syndrome 9.7
730 australia antigen 9.7
731 buerger disease 9.7
732 cohen syndrome 9.7
733 epidermolysis bullosa dystrophica, autosomal recessive 9.7
734 gapo syndrome 9.7
735 factor xii deficiency 9.7
736 homocystinuria due to cystathionine beta-synthase deficiency 9.7
737 3-methylglutaconic aciduria, type iii 9.7
738 bruck syndrome 1 9.7
739 interstitial pneumonitis, desquamative, familial 9.7
740 polycythemia vera 9.7
741 orofaciodigital syndrome viii 9.7
742 menkes disease 9.7
743 reticuloendotheliosis, x-linked 9.7
744 branchiootic syndrome 1 9.7
745 bruck syndrome 2 9.7
746 systemic lupus erythematosus 5 9.7
747 potocki-lupski syndrome 9.7
748 macs syndrome 9.7
749 chromosome 6q11-q14 deletion syndrome 9.7
750 hyperlipoproteinemia, type iii 9.7
751 hypertrophic scars 9.7
752 peyronie's disease 9.7
753 arrhythmogenic right ventricular cardiomyopathy 9.7
754 lissencephaly 9.7
755 tooth agenesis 9.7
756 autosomal recessive disease 9.7
757 recessive dystrophic epidermolysis bullosa 9.7
758 hyper ige syndrome 9.7
759 corneal disease 9.7
760 parotid disease 9.7
761 alport syndrome 9.7
762 scleral disease 9.7
763 visual epilepsy 9.7
764 coronary thrombosis 9.7
765 synostosis 9.7
766 otosclerosis 9.7
767 hyperostosis 9.7
768 thrombocytosis 9.7
769 craniosynostosis 9.7
770 acromegaly 9.7
771 rhizomelic chondrodysplasia punctata 9.7
772 membranoproliferative glomerulonephritis 9.7
773 thoracic outlet syndrome 9.7
774 tracheal stenosis 9.7
775 gm1 gangliosidosis 9.7
776 bone inflammation disease 9.7
777 necrobiosis lipoidica 9.7
778 turner syndrome 9.7
779 granuloma annulare 9.7
780 hypokalemia 9.7
781 dysgraphia 9.7
782 gingival hypertrophy 9.7
783 diffuse infiltrative lymphocytosis syndrome 9.7
784 diverticulitis 9.7
785 polycythemia 9.7
786 chronic fatigue syndrome 9.7
787 learning disability 9.7
788 zellweger syndrome 9.7
789 peroxisomal disease 9.7
790 homocystinuria 9.7
791 carotid artery dissection 9.7
792 developmental coordination disorder 9.7
793 keloid disorder 9.7
794 ltbp4-related cutis laxa 9.7
795 chiari malformation 9.7
796 gangliosidosis 9.7
797 perniosis 9.7
798 spondyloepimetaphyseal dysplasia joint laxity 9.7
799 developmental dyspraxia 9.7
800 seizure disorder 9.7
801 periodic paralysis 9.7
802 spontaneous intracranial hypotension 9.7
803 argyria 9.7
804 b4galt7-related spondylodysplastic ehlers-danlos syndrome 9.7
805 classic pyoderma gangrenosum 9.7
806 achard syndrome 9.7
807 pfeiffer syndrome 9.7
808 alzheimer disease 9.7
809 annular erythema 9.7
810 b-cell growth factor 9.7
811 burkitt lymphoma 9.7
812 breast cancer 9.7
813 cardiac arrhythmia 9.7
814 creatine phosphokinase, elevated serum 9.7
815 dupuytren contracture 9.7
816 ectopia lentis 1, isolated, autosomal dominant 9.7
817 ehlers-danlos syndrome, autosomal dominant, type unspecified 9.7
818 facial spasm 9.7
819 fibromuscular dysplasia 9.7
820 hernia, hiatus 9.7
821 hypercholesterolemia, familial, 1 9.7
822 hyperimmunoglobulin g1 syndrome 9.7
823 hyperthyroxinemia, dystransthyretinemic 9.7
824 hypertriglyceridemia, familial 9.7
825 inclusion body myositis 9.7
826 leukemia, chronic lymphocytic 9.7
827 melkersson-rosenthal syndrome 9.7
828 myelopathy, htlv-1-associated 9.7
829 neutrophil migration 9.7
830 ocular cicatricial pemphigoid 9.7
831 osteogenesis imperfecta, type i 9.7
832 osteogenesis imperfecta, type iv 9.7
833 otitis media 9.7
834 papillomatosis, confluent and reticulated 9.7
835 pectus excavatum 9.7
836 pernicious anemia 9.7
837 pityriasis rubra pilaris 9.7
838 porphyria cutanea tarda 9.7
839 dowling-degos disease 1 9.7
840 schistosoma mansoni infection, susceptibility/ 9.7
841 small cell cancer of the lung 9.7
842 spinal arachnoiditis 9.7
843 thyroid cancer, nonmedullary, 1 9.7
844 trichomegaly 9.7
845 triiodothyronine receptor auxiliary protein 9.7
846 vasculitis, lymphocytic, nodular 9.7
847 vitiligo-associated multiple autoimmune disease susceptibility 6 9.7
848 acrocallosal syndrome 9.7
849 chondrosarcoma 9.7
850 cystic fibrosis 9.7
851 endocardial fibroelastosis 9.7
852 fibrosclerosis, multifocal 9.7
853 renal glucosuria 9.7
854 pulmonary venoocclusive disease 2, autosomal recessive 9.7
855 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.7
856 hypoascorbemia 9.7
857 myeloma, multiple 9.7
858 myosclerosis, autosomal recessive 9.7
859 myxedema 9.7
860 reticulum cell sarcoma 9.7
861 graves disease 1 9.7
862 werner syndrome 9.7
863 systemic lupus erythematosus 15 9.7
864 fabry disease 9.7
865 nuclear ribonucleic acid 9.7
866 aging 9.7
867 kearns-sayre syndrome 9.7
868 helicobacter pylori infection 9.7
869 patent ductus venosus 9.7
870 leukemia, acute myeloid 9.7
871 acute insulin response 9.7
872 astigmatism 9.7
873 homocysteinemia 9.7
874 sickle cell anemia 9.7
875 reflex sympathetic dystrophy 9.7
876 langerhans cell histiocytosis 9.7
877 lymphoma, non-hodgkin, familial 9.7
878 psoriasis 7 9.7
879 phace association 9.7
880 vitiligo-associated multiple autoimmune disease susceptibility 1 9.7
881 lymphangioleiomyomatosis 9.7
882 bone mineral density quantitative trait locus 3 9.7
883 allergic rhinitis 9.7
884 neutrophilic dermatosis, acute febrile 9.7
885 leukemia, chronic myeloid 9.7
886 severe cutaneous adverse reaction 9.7
887 systemic lupus erythematosus 8 9.7
888 esophagitis, eosinophilic, 1 9.7
889 systemic lupus erythematosus 9 9.7
890 diabetes mellitus, ketosis-prone 9.7
891 inflammatory bowel disease 13 9.7
892 systemic lupus erythematosus 10 9.7
893 systemic lupus erythematosus 13 9.7
894 pulmonary hypertension, chronic thromboembolic, without deep vein thrombosis 9.7
895 systemic lupus erythematosus 14 9.7
896 fatty liver disease, nonalcoholic 1 9.7
897 reynolds syndrome 9.7
898 cholangitis, primary sclerosing 9.7
899 aspergillosis 9.7
900 muscle hypertrophy 9.7
901 systemic lupus erythematosus 16 9.7
902 melanoma, cutaneous malignant 10 9.7
903 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 9.7
904 chorea, childhood-onset, with psychomotor retardation 9.7
905 mucopolysaccharidosis-plus syndrome 9.7
906 joint laxity, short stature, and myopia 9.7
907 alkuraya-kucinskas syndrome 9.7
908 lipoprotein quantitative trait locus 9.7
909 chronic ulcer of skin 9.7
910 peripheral vascular disease 9.7
911 angina pectoris 9.7
912 autoimmune vasculitis 9.7
913 pemphigus gestationis 9.7
914 hemophagocytic lymphohistiocytosis 9.7
915 secretory diarrhea 9.7
916 lambert-eaton myasthenic syndrome 9.7
917 brachydactyly 9.7
918 distal arthrogryposis 9.7
919 diffuse large b-cell lymphoma 9.7
920 metabolic acidosis 9.7
921 first-degree atrioventricular block 9.7
922 second-degree atrioventricular block 9.7
923 renal fibrosis 9.7
924 pain agnosia 9.7
925 colitis 9.7
926 ischemic colitis 9.7
927 cogan syndrome 9.7
928 persistent generalized lymphadenopathy 9.7
929 dental abscess 9.7
930 glucocorticoid-induced osteoporosis 9.7
931 drug allergy 9.7
932 purpura fulminans 9.7
933 erythema elevatum diutinum 9.7
934 hereditary lymphedema i 9.7
935 myoglobinuria 9.7
936 chronic myelomonocytic leukemia 9.7
937 igg4-related disease 9.7
938 mucolipidosis 9.7
939 sensorineural hearing loss 9.7
940 venous insufficiency 9.7
941 neuroretinitis 9.7
942 osteomyelitis 9.7
943 parotitis 9.7
944 endocarditis 9.7
945 pneumoconiosis 9.7
946 anthracosis 9.7
947 osteomalacia 9.7
948 mastitis 9.7
949 hypospadias 9.7
950 spotted fever 9.7
951 henoch-schoenlein purpura 9.7
952 diphtheria 9.7
953 mitral valve insufficiency 9.7
954 autonomic neuropathy 9.7
955 fissured tongue 9.7
956 cauda equina syndrome 9.7
957 infant gynecomastia 9.7
958 portal vein thrombosis 9.7
959 multicentric reticulohistiocytosis 9.7
960 cryptococcosis 9.7
961 hemosiderosis 9.7
962 arachnoiditis 9.7
963 common variable immunodeficiency 9.7
964 leukemia 9.7
965 secondary hyperparathyroidism 9.7
966 von willebrand's disease 9.7
967 posterior uveitis 9.7
968 acute leukemia 9.7
969 gynecomastia 9.7
970 hereditary hemorrhagic telangiectasia 9.7
971 capillary disease 9.7
972 choreatic disease 9.7
973 mikulicz disease 9.7
974 focal segmental glomerulosclerosis 9.7
975 hellp syndrome 9.7
976 porphyria 9.7
977 pulmonary sarcoidosis 9.7
978 tuberous sclerosis 9.7
979 hyperparathyroidism 9.7
980 anterior scleritis 9.7
981 facial neuralgia 9.7
982 interstitial cystitis 9.7
983 schistosomiasis 9.7
984 peptic esophagitis 9.7
985 algoneurodystrophy 9.7
986 iritis 9.7
987 toxic shock syndrome 9.7
988 pyuria 9.7
989 gonadal dysgenesis 9.7
990 pemphigoid gestationis 9.7
991 neuronal ceroid lipofuscinosis 9.7
992 hypersensitivity reaction type iii disease 9.7
993 fungal infectious disease 9.7
994 acute chest syndrome 9.7
995 keratosis 9.7
996 ichthyosis 9.7
997 retinal vein occlusion 9.7
998 histoplasmosis 9.7
999 cheilitis 9.7
1000 factitious disorder 9.7
1001 hepatitis c 9.7
1002 melanoma 9.7
1003 hypogonadism 9.7
1004 telogen effluvium 9.7
1005 intestinal perforation 9.7
1006 hidradenitis suppurativa 9.7
1007 hidradenitis 9.7
1008 iron metabolism disease 9.7
1009 central retinal vein occlusion 9.7
1010 gastric antral vascular ectasia 9.7
1011 dermatitis 9.7
1012 epidermolysis bullosa 9.7
1013 skin atrophy 9.7
1014 contact dermatitis 9.7
1015 acute interstitial pneumonia 9.7
1016 hyperthyroxinemia 9.7
1017 euthyroid sick syndrome 9.7
1018 aleutian mink disease 9.7
1019 anuria 9.7
1020 iga glomerulonephritis 9.7
1021 food allergy 9.7
1022 scleredema adultorum 9.7
1023 cutis laxa 9.7
1024 lipid metabolism disorder 9.7
1025 lipomatosis 9.7
1026 tropical spastic paraparesis 9.7
1027 lysosomal storage disease 9.7
1028 demyelinating disease 9.7
1029 mood disorder 9.7
1030 histiocytosis 9.7
1031 granulomatous myositis 9.7
1032 plague 9.7
1033 sagittal sinus thrombosis 9.7
1034 retinitis 9.7
1035 plexopathy 9.7
1036 brachial plexus neuritis 9.7
1037 plasmacytoma 9.7
1038 protein c deficiency 9.7
1039 thrombophlebitis 9.7
1040 acute myocarditis 9.7
1041 restrictive cardiomyopathy 9.7
1042 eosinophilic gastritis 9.7
1043 eosinophilic gastroenteritis 9.7
1044 intracranial thrombosis 9.7
1045 hair disease 9.7
1046 pyoderma 9.7
1047 granulomatous dermatitis 9.7
1048 neuromuscular disease 9.7
1049 rhinitis 9.7
1050 large cell carcinoma 9.7
1051 type c thymoma 9.7
1052 uremia 9.7
1053 brain edema 9.7
1054 aortitis 9.7
1055 ureteral obstruction 9.7
1056 infertility 9.7
1057 aortic valve prolapse 9.7
1058 human immunodeficiency virus infectious disease 9.7
1059 intestinal disease 9.7
1060 t-cell adult acute lymphocytic leukemia 9.7
1061 eye disease 9.7
1062 subendocardial myocardial infarction 9.7
1063 eosinophilic pneumonia 9.7
1064 esophageal disease 9.7
1065 complement deficiency 9.7
1066 acquired immunodeficiency syndrome 9.7
1067 hypersplenism 9.7
1068 acute disseminated encephalomyelitis 9.7
1069 inherited metabolic disorder 9.7
1070 lung lymphoma 9.7
1071 compartment syndrome 9.7
1072 b-cell lymphoma 9.7
1073 peptic ulcer disease 9.7
1074 chronic kidney disease 9.7
1075 carotid artery occlusion 9.7
1076 cocaine abuse 9.7
1077 ileus 9.7
1078 paralytic ileus 9.7
1079 influenza 9.7
1080 acute cor pulmonale 9.7
1081 reticulosarcoma 9.7
1082 pyoderma gangrenosum 9.7
1083 ulcerative colitis 9.7
1084 eating disorder 9.7
1085 decubitus ulcer 9.7
1086 crohn's disease 9.7
1087 rubella 9.7
1088 intermediate coronary syndrome 9.7
1089 lichen planus 9.7
1090 erythromelalgia 9.7
1091 orbital disease 9.7
1092 diabetes mellitus 9.7
1093 orbital plasma cell granuloma 9.7
1094 exophthalmos 9.7
1095 diabetes insipidus 9.7
1096 fatty liver disease 9.7
1097 dacryoadenitis 9.7
1098 encephalitis 9.7
1099 necrotizing fasciitis 9.7
1100 diastolic heart failure 9.7
1101 alopecia areata 9.7
1102 hypoglycemia 9.7
1103 hemophilia 9.7
1104 amaurosis fugax 9.7
1105 autoimmune encephalitis 9.7
1106 autoimmune enteropathy 9.7
1107 chromosomal triplication 9.7
1108 chronic thromboembolic pulmonary hypertension 9.7
1109 congenital contractures 9.7
1110 coronary artery aneurysm 9.7
1111 cutaneous sclerosis 9.7
1112 diffuse cutaneous systemic sclerosis 9.7
1113 diffuse mesangial sclerosis 9.7
1114 dwarfism 9.7
1115 fibrillary glomerulonephritis 9.7
1116 homologous wasting disease 9.7
1117 htlv-1 associated myelopathy/tropical spastic paraparesis 9.7
1118 hypocomplementemic urticarial vasculitis 9.7
1119 kikuchi disease 9.7
1120 lathyrism 9.7
1121 mycobacterium chelonae 9.7
1122 mycobacterium xenopi 9.7
1123 myelodysplastic syndrome with excess blasts 9.7
1124 pityriasis lichenoides 9.7
1125 scleromyxedema 9.7
1126 spastic paraparesis 9.7
1127 thrombotic thrombocytopenic purpura, acquired 9.7
1128 vitreoretinal degeneration 9.7
1129 paraneoplastic syndromes 9.7
1130 syncope 9.7
1131 chronic cutaneous lupus erythematosus 9.7
1132 progeroid syndrome 9.7
1133 linear atrophoderma of moulin 9.7
1134 inflammatory myopathy with abundant macrophages 9.7
1135 isolated pulmonary capillaritis 9.7
1136 pulmonary hypertension owing to lung disease and/or hypoxia 9.7
1137 overlap myositis 9.7
1138 rare hereditary hemochromatosis 9.7
1139 cranial neuralgia 9.7
1140 primary anetoderma 9.7
1141 acute pandysautonomia 9.7
1142 acute sensory ataxic neuropathy 9.7
1143 pseudo-meigs syndrome 9.7
1144 primary eosinophilic gastrointestinal disease 9.7
1145 non-inflammatory vasculopathy 9.7
1146 congenital amyoplasia 9.7
1147 focal myositis 9.7
1148 mixed-type autoimmune hemolytic anemia 9.7
1149 lupus erythematosus panniculitis 9.7
1150 pauci-immune glomerulonephritis 9.7
1151 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 9.7
1152 cardiogenic shock 9.7
1153 severe immune-mediated enteropathy 9.7
1154 glomerular disease 9.7
1155 autoinflammatory syndrome 9.7
1156 refractory anemia 9.7
1157 rare pulmonary disease 9.7
1158 thyroid carcinoma 9.7

Graphical network of the top 20 diseases related to Connective Tissue Disease:



Diseases related to Connective Tissue Disease

Symptoms & Phenotypes for Connective Tissue Disease

UMLS symptoms related to Connective Tissue Disease:


back pain, sciatica, muscle cramp, joint symptom, musculoskeletal symptom

MGI Mouse Phenotypes related to Connective Tissue Disease:

45 (showing 25, show less)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.54 ACTA2 BMPR2 COL1A1 COL1A2 COL2A1 COL3A1
2 cellular MP:0005384 10.51 BMPR2 CENPB COL1A1 COL1A2 COL2A1 COL3A1
3 growth/size/body region MP:0005378 10.5 BMPR2 CENPB COL1A1 COL1A2 COL2A1 COL3A1
4 immune system MP:0005387 10.47 ADAMTS13 BMPR2 COL1A1 COL1A2 COL2A1 COL3A1
5 behavior/neurological MP:0005386 10.46 BMPR2 COL1A1 COL1A2 COL2A1 EDNRA FBN1
6 hematopoietic system MP:0005397 10.46 ADAMTS13 BMPR2 COL1A1 COL1A2 COL3A1 EDNRA
7 homeostasis/metabolism MP:0005376 10.45 ADAMTS13 BMPR2 COL1A1 COL1A2 COL2A1 COL3A1
8 mortality/aging MP:0010768 10.45 ADAMTS13 BMPR2 CENPB COL1A1 COL1A2 COL2A1
9 integument MP:0010771 10.4 BMPR2 COL1A1 COL1A2 COL3A1 COL5A1 EDNRA
10 digestive/alimentary MP:0005381 10.33 COL1A1 COL2A1 COL3A1 EDNRA FLNA IL6
11 embryo MP:0005380 10.32 BMPR2 COL1A1 COL2A1 COL5A1 EDNRA FBN1
12 craniofacial MP:0005382 10.3 COL1A1 COL2A1 EDNRA FBN1 FBN2 FLNA
13 adipose tissue MP:0005375 10.28 COL1A1 COL1A2 COL2A1 COL3A1 FBN1 FBN2
14 endocrine/exocrine gland MP:0005379 10.27 CENPB COL1A1 EDNRA FBN1 IL6 NOTCH1
15 muscle MP:0005369 10.27 ACTA2 BMPR2 COL1A1 COL1A2 COL3A1 EDNRA
16 nervous system MP:0003631 10.22 BMPR2 COL1A1 COL1A2 COL2A1 EDNRA FBN1
17 liver/biliary system MP:0005370 10.19 COL1A1 COL2A1 COL3A1 FBN2 FLNA IL6
18 normal MP:0002873 10.15 ADAMTS13 BMPR2 CENPB COL1A1 COL1A2 COL2A1
19 limbs/digits/tail MP:0005371 10.05 COL1A1 COL1A2 COL2A1 FBN1 FBN2 SMAD3
20 neoplasm MP:0002006 9.98 COL1A1 IL6 LOX NOTCH1 SMAD3 TGFBR2
21 respiratory system MP:0005388 9.97 BMPR2 COL1A1 COL2A1 COL3A1 EDNRA FBN1
22 renal/urinary system MP:0005367 9.96 BMPR2 COL1A1 COL2A1 EDNRA FBN1 FBN2
23 pigmentation MP:0001186 9.8 ADAMTS13 BMPR2 COL1A1 FBN1 NOTCH1 TGFBR2
24 skeleton MP:0005390 9.8 BMPR2 COL1A1 COL1A2 COL2A1 EDNRA FBN1
25 vision/eye MP:0005391 9.5 ACTA2 ADAMTS13 BMPR2 COL1A1 COL1A2 COL2A1

Drugs & Therapeutics for Connective Tissue Disease

Drugs for Connective Tissue Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(showing 316, show less)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pirfenidone Approved, Investigational Phase 4 53179-13-8 40632
2
Budesonide Approved Phase 4 51333-22-3 63006 5281004
3
Aminolevulinic acid Approved Phase 4 106-60-5 137
4
Linezolid Approved, Investigational Phase 4 165800-03-3 441401
5
Cilostazol Approved, Investigational Phase 4 73963-72-1 2754
6
Ketorolac Approved Phase 4 66635-83-4, 74103-06-3 3826
7
Nepafenac Approved, Investigational Phase 4 78281-72-8 151075
8
Etanercept Approved, Investigational Phase 4 185243-69-0
9
Silver sulfadiazine Approved, Vet_approved Phase 4 22199-08-2 441244
10
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
11
Nitric Oxide Approved Phase 4 10102-43-9 145068
12
Isosorbide Dinitrate Approved, Investigational Phase 4 87-33-2 6883
13
AT-101 Approved, Investigational Phase 4 652-67-5, 90141-22-3 12597
14
Ramipril Approved Phase 4 87333-19-5 5362129
15
Pioglitazone Approved, Investigational Phase 4 111025-46-8 4829
16
Bisoprolol Approved Phase 4 66722-44-9 2405
17
Sirolimus Approved, Investigational Phase 4 53123-88-9 5284616 6436030 46835353
18
leucovorin Approved Phase 4 58-05-9 6006 143
19
Adalimumab Approved Phase 4 331731-18-1 16219006
20
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
21
Clotrimazole Approved, Vet_approved Phase 4 23593-75-1 2812
22
Miconazole Approved, Investigational, Vet_approved Phase 4 22916-47-8 4189
23
Valsartan Approved, Investigational Phase 4 137862-53-4 60846
24
Mycophenolic acid Approved Phase 4 24280-93-1 446541
25
Ursodeoxycholic acid Approved, Investigational Phase 4 128-13-2 31401
26
Bosentan Approved, Investigational Phase 4 147536-97-8 104865
27
Aspirin Approved, Vet_approved Phase 4 50-78-2 2244
28
Ambrisentan Approved, Investigational Phase 4 177036-94-1 6918493
29
Macitentan Approved Phase 4 441798-33-0
30
Folic acid Approved, Nutraceutical, Vet_approved Phase 4 59-30-3 6037
31 Beraprost Investigational Phase 4 88430-50-6
32 Photosensitizing Agents Phase 4
33 Adrenergic beta-Agonists Phase 4
34 Formoterol Fumarate Phase 4
35 Methyl 5-aminolevulinate Phase 4
36 Vasodilator Agents Phase 4
37 Calcium, Dietary Phase 4
38 Antimetabolites Phase 4
39 Lipid Regulating Agents Phase 4
40 Hypolipidemic Agents Phase 4
41 Phosphodiesterase 3 Inhibitors Phase 4
42 Adrenergic beta-1 Receptor Antagonists Phase 4
43 Neurotransmitter Agents Phase 4
44 Adrenergic Agents Phase 4
45 Sympatholytics Phase 4
46 Adrenergic Antagonists Phase 4
47 Adrenergic beta-Antagonists Phase 4
48 Angiotensin-Converting Enzyme Inhibitors Phase 4
49 Ketorolac Tromethamine Phase 4
50 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4
51 Anticholesteremic Agents Phase 4
52 Rosuvastatin Calcium Phase 4 147098-20-2
53 Insulin, Globin Zinc Phase 4
54
protease inhibitors Phase 4
55 insulin Phase 4
56 HIV Protease Inhibitors Phase 4
57 diuretics Phase 4
58 Hypoglycemic Agents Phase 4
59 isosorbide-5-mononitrate Phase 4
60 Antineoplastic Agents, Hormonal Phase 4
61 Vitamin B Complex Phase 4
62 Folic Acid Antagonists Phase 4
63 Folate Phase 4
64 Vitamin B9 Phase 4
65 Angiotensin II Type 1 Receptor Blockers Phase 4
66 Angiotensinogen Phase 4
67 Angiotensin Receptor Antagonists Phase 4
68 Giapreza Phase 4
69 Antitubercular Agents Phase 4
70 Anti-Bacterial Agents Phase 4
71 Antifungal Agents Phase 4
72 Antibiotics, Antitubercular Phase 4
73 LCZ 696 Phase 4
74 Dermatologic Agents Phase 4
75 Cyclosporins Phase 4
76 Calcineurin Inhibitors Phase 4
77 Antihypertensive Agents Phase 4
78 Antirheumatic Agents Phase 4
79 Fibrinolytic Agents Phase 4
80 Analgesics, Non-Narcotic Phase 4
81 Platelet Aggregation Inhibitors Phase 4
82 Analgesics Phase 4
83 Antipyretics Phase 4
84 Cyclooxygenase Inhibitors Phase 4
85 Anti-Inflammatory Agents Phase 4
86 Anti-Inflammatory Agents, Non-Steroidal Phase 4
87
Calcium Nutraceutical Phase 4 7440-70-2 271
88
Sulfamethoxazole Approved Phase 2, Phase 3 723-46-6 5329
89
Trimethoprim Approved, Vet_approved Phase 2, Phase 3 738-70-5 5578