MCID: ABC021
MIFTS: 20

Abacavir Allergy

Categories: Immune diseases

Aliases & Classifications for Abacavir Allergy

MalaCards integrated aliases for Abacavir Allergy:

Name: Abacavir Allergy 12 15
Abc Allergy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0040007

Summaries for Abacavir Allergy

Disease Ontology : 12 A drug allergy that has allergic trigger abacavir.

MalaCards based summary : Abacavir Allergy, also known as abc allergy, is related to thiopurines, poor metabolism of, 1 and hypertrophy of tongue papillae. An important gene associated with Abacavir Allergy is CYP2B6 (Cytochrome P450 Family 2 Subfamily B Member 6), and among its related pathways/superpathways are Statin Pathway - Generalized, Pharmacokinetics and IL12-mediated signaling events. Affiliated tissues include nk cells and tongue.

Related Diseases for Abacavir Allergy

Diseases related to Abacavir Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 thiopurines, poor metabolism of, 1 10.4 VKORC1 SLCO1B1
2 hypertrophy of tongue papillae 10.3 CYP2C9 CYP2B6
3 diffuse alveolar hemorrhage 10.3 VKORC1 CYP2C9
4 vitamin k antagonists toxicity or dose selection 10.3 VKORC1 CYP2C9
5 phenytoin toxicity 10.3 VKORC1 CYP2C9
6 acute frontal sinusitis 10.2 CYP2B6 CCL11
7 coumarin resistance 10.2 VKORC1 CYP2C9
8 drug-induced hepatitis 10.1 IFNL3 CYP2C9
9 hepatitis d 10.0 IFNL3 CYP2C9
10 latent syphilis 10.0 SNORD95 CD4
11 hemorrhagic cystitis 9.9 CYP2B6 CD4
12 aggressive nk-cell leukemia 9.9 GZMB CCR5
13 esophageal candidiasis 9.9 CYP2C9 CD4
14 blepharoconjunctivitis 9.8 CD4 CCL11
15 churg-strauss syndrome 9.8 HMGB1 CCL17 CCL11
16 intrinsic asthma 9.8 CD4 CCL11
17 chronic meningitis 9.8 CD4 CCL11
18 scabies 9.8 CD4 CCL11
19 chronic conjunctivitis 9.8 CD4 CCL11
20 west nile encephalitis 9.8 CD4 CCR5
21 chancroid 9.8 CD4 CCR5
22 strongyloidiasis 9.8 CD4 CCL11
23 trichomoniasis 9.7 CD4 CCR5
24 viral esophagitis 9.7 GZMB CD4
25 pneumocystosis 9.7 CD4 CCR5
26 cytomegalovirus retinitis 9.7 CD4 CCR5
27 hantavirus hemorrhagic fever with renal syndrome 9.6 GZMB CD4
28 autoimmune glomerulonephritis 9.6 GZMB CD4
29 giardiasis 9.6 GZMB CD4
30 fallopian tube disease 9.6 CD4 CCR5
31 immune-complex glomerulonephritis 9.6 CD4 CCR5
32 nasal cavity disease 9.6 CD4 CCL17 CCL11
33 nose disease 9.6 CD4 CCL17 CCL11
34 respiratory allergy 9.6 CD4 CCL17 CCL11
35 endophthalmitis 9.6 HMGB1 CD4
36 bronchial disease 9.6 CD4 CCL17 CCL11
37 vaginitis 9.6 CD4 CCR5
38 cryptosporidiosis 9.5 CD4 CCL11
39 anaplastic large cell lymphoma 9.4 GZMB CD4 CCL17
40 allergic hypersensitivity disease 9.4 CD4 CCL17 CCL11
41 mycobacterium tuberculosis 1 9.4 GZMB CYP2B6 CD4
42 granulomatosis with polyangiitis 9.4 HMGB1 CD4 CCR5
43 folliculitis 9.3 CD4 CCL11
44 human immunodeficiency virus infectious disease 9.3 GZMB CD4 CCR5
45 respiratory failure 9.3 CD4 CCL17 CCL11 ANPEP
46 severe cutaneous adverse reaction 9.1 VKORC1 GZMB CYP2C9 CYP2B6 CD4
47 pulmonary disease, chronic obstructive 9.0 GZMB CD4 CCR5 CCL11
48 viral infectious disease 8.9 GZMB CD4 CCR5

Graphical network of the top 20 diseases related to Abacavir Allergy:



Diseases related to Abacavir Allergy

Symptoms & Phenotypes for Abacavir Allergy

Drugs & Therapeutics for Abacavir Allergy

Search Clinical Trials , NIH Clinical Center for Abacavir Allergy

Genetic Tests for Abacavir Allergy

Anatomical Context for Abacavir Allergy

MalaCards organs/tissues related to Abacavir Allergy:

40
Nk Cells, Tongue

Publications for Abacavir Allergy

Variations for Abacavir Allergy

Expression for Abacavir Allergy

Search GEO for disease gene expression data for Abacavir Allergy.

Pathways for Abacavir Allergy

Pathways related to Abacavir Allergy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.49 SLCO1B1 CYP2C9 CYP2B6
2
Show member pathways
11.38 GZMB CD4 CCR5
3
Show member pathways
11.01 SLCO1B1 CYP2C9 CYP2B6
4
Show member pathways
10.94 SLCO1B1 CYP2C9
5 10.87 CYP2C9 CYP2B6
6
Show member pathways
10.62 CYP2C9 CYP2B6
7 10.46 CD4 CCL17 CCL11

GO Terms for Abacavir Allergy

Biological processes related to Abacavir Allergy according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.83 CD4 CCR5 CCL17 CCL11
2 inflammatory response GO:0006954 9.76 HMGB1 CCR5 CCL17 CCL11
3 cytokine-mediated signaling pathway GO:0019221 9.71 IFNL3 CD4 CCR5 CCL11
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.56 HMGB1 CD4 CCL17 CCL11
5 chemokine-mediated signaling pathway GO:0070098 9.54 CCR5 CCL17 CCL11
6 exogenous drug catabolic process GO:0042738 9.51 CYP2C9 CYP2B6
7 organic acid metabolic process GO:0006082 9.49 CYP2C9 CYP2B6
8 epoxygenase P450 pathway GO:0019373 9.48 CYP2C9 CYP2B6
9 dendritic cell chemotaxis GO:0002407 9.43 HMGB1 CCR5
10 fusion of virus membrane with host plasma membrane GO:0019064 9.32 CD4 CCR5
11 chemotaxis GO:0006935 9.26 HMGB1 CCR5 CCL17 CCL11
12 entry into host cell GO:0030260 9.16 CD4 CCR5
13 drug metabolic process GO:0017144 8.8 VKORC1 CYP2C9 CYP2B6

Molecular functions related to Abacavir Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 CCR chemokine receptor binding GO:0048020 9.37 CCL17 CCL11
2 steroid hydroxylase activity GO:0008395 9.32 CYP2C9 CYP2B6
3 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.26 CYP2C9 CYP2B6
4 arachidonic acid epoxygenase activity GO:0008392 9.16 CYP2C9 CYP2B6
5 virus receptor activity GO:0001618 9.13 CD4 CCR5 ANPEP
6 cytokine activity GO:0005125 8.92 IFNL3 HMGB1 CCL17 CCL11

Sources for Abacavir Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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