Abdominal Obesity-Metabolic Syndrome 4 disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Abdominal Obesity-Metabolic Syndrome 4

MalaCards integrated aliases for Abdominal Obesity-Metabolic Syndrome 4:

Name: Abdominal Obesity-Metabolic Syndrome 4 ⁵⁶

Aoms4 ⁵⁶

Characteristics:

OMIM:

⁵⁶

Inheritance:
autosomal dominant

Classifications:

MalaCards categories:
Global: Genetic diseases Metabolic diseases
Anatomical: Cardiovascular diseases Blood diseases

See all MalaCards categories (disease lists)

External Ids:

OMIM ⁵⁶ 618620

OMIM Phenotypic Series ⁵⁶ PS605552

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Summaries for Abdominal Obesity-Metabolic Syndrome 4

OMIM : ⁵⁶ Abdominal obesity-metabolic syndrome-4 (AOMS4) is characterized by obesity, hypertension, and early-onset coronary artery disease. Most affected individuals meet the criteria for metabolic syndrome, including elevated triglyceride and low high-density lipoprotein levels, and type 2 diabetes (Esteghamat et al., 2019). For a discussion of the genetic heterogeneity of abdominal obesity-metabolic syndrome, see AOMS1 (605552). (618620)

MalaCards based summary : Abdominal Obesity-Metabolic Syndrome 4, is also known as aoms4. An important gene associated with Abdominal Obesity-Metabolic Syndrome 4 is CELA2A (Chymotrypsin Like Elastase 2A).

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Related Diseases for Abdominal Obesity-Metabolic Syndrome 4

Diseases in the Abdominal Obesity-Metabolic Syndrome 1 family:

Abdominal Obesity-Metabolic Syndrome 3

Abdominal Obesity-Metabolic Syndrome 4

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Symptoms & Phenotypes for Abdominal Obesity-Metabolic Syndrome 4

Symptoms via clinical synopsis from OMIM:

⁵⁶

Cardiovascular Vascular:
hypertension

Cardiovascular Heart:
coronary artery disease, early-onset
myocardial infarction, early-onset

Endocrine Features:
type 2 diabetes mellitus (t2d)

Laboratory Abnormalities:
elevated hemoglobin a1c (hba1c)
elevated fasting blood glucose
markedly elevated triglycerides
low high-density lipoprotein (hdl)

Growth Weight:
elevated body mass index

Clinical features from OMIM:

618620

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Drugs & Therapeutics for Abdominal Obesity-Metabolic Syndrome 4

Search Clinical Trials , NIH Clinical Center for Abdominal Obesity-Metabolic Syndrome 4

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Genetic Tests for Abdominal Obesity-Metabolic Syndrome 4

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Anatomical Context for Abdominal Obesity-Metabolic Syndrome 4

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Publications for Abdominal Obesity-Metabolic Syndrome 4

Articles related to Abdominal Obesity-Metabolic Syndrome 4:

#	Title	Authors	PMID	Year
1	CELA2A mutations predispose to early-onset atherosclerosis and metabolic syndrome and affect plasma insulin and platelet activation. ⁵⁶	Esteghamat F...Mani A	31358993	2019

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Genes for Abdominal Obesity-Metabolic Syndrome 4

Genes related to Abdominal Obesity-Metabolic Syndrome 4 (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	CELA2A	Chymotrypsin Like Elastase 2A	Protein Coding	500	Molecular basis known ⁵⁶

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Variations for Abdominal Obesity-Metabolic Syndrome 4

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Expression for Abdominal Obesity-Metabolic Syndrome 4

Search GEO for disease gene expression data for Abdominal Obesity-Metabolic Syndrome 4.

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Pathways for Abdominal Obesity-Metabolic Syndrome 4

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GO Terms for Abdominal Obesity-Metabolic Syndrome 4

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Sources for Abdominal Obesity-Metabolic Syndrome 4

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Abdominal Obesity-Metabolic Syndrome 4 (AOMS4)

Aliases & Classifications for Abdominal Obesity-Metabolic Syndrome 4

MalaCards integrated aliases for Abdominal Obesity-Metabolic Syndrome 4:

Characteristics:

OMIM:

Classifications:

External Ids:

Summaries for Abdominal Obesity-Metabolic Syndrome 4

Related Diseases for Abdominal Obesity-Metabolic Syndrome 4

Diseases in the Abdominal Obesity-Metabolic Syndrome 1 family:

Symptoms & Phenotypes for Abdominal Obesity-Metabolic Syndrome 4

Symptoms via clinical synopsis from OMIM:

Clinical features from OMIM:

Drugs & Therapeutics for Abdominal Obesity-Metabolic Syndrome 4

Genetic Tests for Abdominal Obesity-Metabolic Syndrome 4

Anatomical Context for Abdominal Obesity-Metabolic Syndrome 4

Publications for Abdominal Obesity-Metabolic Syndrome 4

Articles related to Abdominal Obesity-Metabolic Syndrome 4:

Genes for Abdominal Obesity-Metabolic Syndrome 4

Genes related to Abdominal Obesity-Metabolic Syndrome 4 (1 elite genes):

Variations for Abdominal Obesity-Metabolic Syndrome 4

Expression for Abdominal Obesity-Metabolic Syndrome 4

Pathways for Abdominal Obesity-Metabolic Syndrome 4

GO Terms for Abdominal Obesity-Metabolic Syndrome 4

Sources for Abdominal Obesity-Metabolic Syndrome 4