MCID: ABD010
MIFTS: 33

Abdominal Wall Defect

Categories: Gastrointestinal diseases

Aliases & Classifications for Abdominal Wall Defect

Summaries for Abdominal Wall Defect

Genetics Home Reference : 25 An abdominal wall defect is an opening in the abdomen through which various abdominal organs can protrude. This opening varies in size and can usually be diagnosed early in fetal development, typically between the tenth and fourteenth weeks of pregnancy. There are two main types of abdominal wall defects: omphalocele and gastroschisis. Omphalocele is an opening in the center of the abdominal wall where the umbilical cord meets the abdomen. Organs (typically the intestines, stomach, and liver) protrude through the opening into the umbilical cord and are covered by the same protective membrane that covers the umbilical cord. Gastroschisis is a defect in the abdominal wall, usually to the right of the umbilical cord, through which the large and small intestines protrude (although other organs may sometimes bulge out). There is no membrane covering the exposed organs in gastroschisis.

MalaCards based summary : Abdominal Wall Defect, also known as abnormality of the abdominal wall, is related to shprintzen omphalocele syndrome and shprintzen-goldberg craniosynostosis syndrome. The drugs Abatacept and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include small intestine, liver and skin.

Wikipedia : 76 Abdominal wall defects are a type of congenital defect that allows the stomach, the intestines, or other... more...

Related Diseases for Abdominal Wall Defect

Graphical network of the top 20 diseases related to Abdominal Wall Defect:



Diseases related to Abdominal Wall Defect

Symptoms & Phenotypes for Abdominal Wall Defect

Drugs & Therapeutics for Abdominal Wall Defect

Drugs for Abdominal Wall Defect (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abatacept Approved Phase 2 332348-12-6 10237
2 Immunosuppressive Agents Phase 2,Early Phase 1
3 Antirheumatic Agents Phase 2
4
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
5
Tacrolimus Approved, Investigational Early Phase 1 104987-11-3 445643 439492
6
Mycophenolic acid Approved Early Phase 1 24280-93-1 446541
7
Mycophenolate mofetil Approved, Investigational Early Phase 1 128794-94-5 5281078
8
Prednisone Approved, Vet_approved Early Phase 1 53-03-2 5865
9 Analgesics Not Applicable
10 Central Nervous System Depressants Not Applicable
11 Anesthetics Not Applicable
12 Anesthetics, Local Not Applicable
13 Peripheral Nervous System Agents Not Applicable
14 Pharmaceutical Solutions Not Applicable

Interventional clinical trials:

(show all 22)
# Name Status NCT ID Phase Drugs
1 Safety Study of MotifMESH (cPTFE) in Abdominal Surgery Completed NCT01364233 Phase 4
2 Open Mesh Versus Suture Repair in Treatment of Abdominal Wall Hernias Completed NCT01018524 Phase 4
3 Prospective Trial Comparing the Performance Profiles of Two Non-Cross-Linked Porcine Dermal Matrices in Abdominal Wall Reconstruction Recruiting NCT02228889 Phase 4
4 Repair of Challenging Abdominal Wall Defects: Strattice(TM) TM in Abdominal Wall Repair (StAR) Terminated NCT01083472 Phase 4
5 TIGR vs Polypropylene (Permanent) Mesh: Randomised Trial Unknown status NCT01136603 Phase 2
6 "BP as a New Device for Surgery and Solid Cancer and Hematopoietic System Tumors Treatment. Effects of BP Implantation" Unknown status NCT02328352 Phase 1, Phase 2
7 Abdominal Wall Transplant Not yet recruiting NCT03310905 Phase 2 Belatacept 5mg/kg IV monthly
8 BP as a Super-light Mesh and as a New Fixation Device for General Surgery -DM108/2008-B Unknown status NCT02341222 Early Phase 1
9 A Retrospective Study Evaluating the Use of Permacol Surgical Implant in the Repair of Abdominal Wall Defects Completed NCT01214252
10 Feasibility Study of The Use of FLEX HD® Surgical Implant or STRATTICE® Reconstructive Tissue Matrix in The Closure of Abdominal Wall Defects With Component Separation in Clean or Contaminated Cases Completed NCT01597128 Not Applicable
11 Giant Ventral Incisional Hernia: Abdominal Wall Function, Respiratory Performance and Quality of Life Completed NCT02011048
12 The Permacol Dutch Cohort Study Completed NCT02166112
13 Intra-Abdominal Hypertension in Neonatal Intensive Care Patients Completed NCT00747552
14 Vascularized Composite Allotransplantation for Treatment of Abdominal Wall Defects Recruiting NCT02416674 Early Phase 1 Immunosuppressive Agents
15 The Use of Biologic Mesh vs Bioabsorbable Mesh During Ventral Hernia Repair in At-risk Patients Recruiting NCT01794338 Not Applicable
16 Study to Evaluate Reduction in Pain After Laparoscopic Hernia Repair With Mesh Soaked in Bupivacaine Solution Recruiting NCT03035617 Not Applicable Bupivacaine
17 Oral Care in Infants With Gastroschisis Recruiting NCT03393832 Not Applicable
18 Novel Strategies to Improve Immunomodulation and Non-invasive Clinical Monitoring in VCA Recruiting NCT03241719 Early Phase 1 IL-2
19 ENHANCE: A Prospective EvaluatioN of Permacol™ in tHe Repair of Complex AbdomiNal Wall CasEs Active, not recruiting NCT01268514
20 Intraoperative Biomechanics in Complex Abdominal Wall Reconstruction Enrolling by invitation NCT03296475 Not Applicable
21 Abdominal Wall Repair With Strattice in Germany: a Cohort Study Enrolling by invitation NCT02168231
22 Review of Complex Recurrent Hernia Repair Enrolling by invitation NCT01644695

Search NIH Clinical Center for Abdominal Wall Defect

Genetic Tests for Abdominal Wall Defect

Genetic tests related to Abdominal Wall Defect:

# Genetic test Affiliating Genes
1 Abnormality of the Abdominal Wall 29

Anatomical Context for Abdominal Wall Defect

MalaCards organs/tissues related to Abdominal Wall Defect:

41
Small Intestine, Liver, Skin, Lung, Breast

Publications for Abdominal Wall Defect

Articles related to Abdominal Wall Defect:

(show top 50) (show all 216)
# Title Authors Year
1
Comparison of small intestinal submucosa and polypropylene mesh for abdominal wall defect repair. ( 29375018 )
2018
2
Ex utero intrapartum treatment for giant congenital omphalocele. ( 29508360 )
2018
3
Sliding free transverse rectus abdominis myocutaneous flap for closure of a massive abdominal wall defect: A case report. ( 29451331 )
2018
4
An Immunopathological Evaluation of the Porcine Cholecyst Matrix as a Muscle Repair Graft in a Male Rat Abdominal Wall Defect Model. ( 29334850 )
2018
5
Enhancement of abdominal wall defect repair using allogenic platelet-rich plasma with commercial polyester/cotton fabric (Damour) in a canine model. ( 28603214 )
2017
6
Electrospun biodegradable microfibers induce new collagen formation in a rat abdominal wall defect model: A possible treatment for pelvic floor repair? ( 28306194 )
2017
7
Reconstruction of a large full-thickness abdominal wall defect with flow-through-based alt flaps: A case report. ( 29232006 )
2017
8
Large Chest and Abdominal Wall Defect Reconstruction With Anterolateral Thigh Free Flap to Right Gastroepiploic Artery Anastomosis. ( 28959374 )
2017
9
Complex abdominal wall defect repair using biologic porcine matrix. ( 28217988 )
2017
10
Biomechanical properties and healing effects of chitin patch in a rat full-thickness abdominal wall defect model. ( 28922558 )
2017
11
Study of a new biodegradable hernia patch to repair abdominal wall defect in rats. ( 28606533 )
2017
12
The risk of midgut volvulus in patients with abdominal wall defects: A multi-institutional study. ( 27847120 )
2017
13
Component separation in the management of abdominal wall defect after laparostomy: Clinical and anatomical videos (with video). ( 28595856 )
2017
14
Application of a Silicone Sheet in Negative-Pressure Wound Therapy to Treat an Abdominal Wall Defect after Necrotizing Fasciitis. ( 28194352 )
2017
15
Nitro-oleic acid (NO2OA) release enhances regional angiogenesis in a rat abdominal wall defect model. ( 29187125 )
2017
16
Not gastroschisis or omphalocele or anything in between: a novel congenital abdominal wall defect. ( 28271155 )
2017
17
Metachronous carcinoma of rectum with reconstruction of a full-thickness abdominal wall defect using a pedicled anterolateral thigh flap. ( 27161142 )
2016
18
Ventral abdominal wall defect correction in rats with contaminated meshes. ( 27828602 )
2016
19
Does a large abdominal wall defect affect lung growth? ( 27692627 )
2016
20
A Neurotized Anterolateral Thigh Flap With a Unique Anastomosis to the Gastroepiploic Artery: A Case Report of a Reconstruction of Composite Abdominal Wall Defect. ( 27499826 )
2016
21
Reconstruction of massive full-thickness abdominal wall defect: successful treatment with nonabsorbable mesh, negative pressure wound therapy, and split-skin grafting. ( 27761251 )
2016
22
Abdominal Wall Defect Reconstructed by Breast Flaps Using a Mercedes Closure Pattern. ( 26913520 )
2016
23
Abdominal Wall Defects among Mexican American Infants: The Effect of Maternal Nativity. ( 27103766 )
2016
24
Congenital omphalocele and cleft palate in two fetuses. ( 26867152 )
2016
25
Mechanical strength vs. degradation of a biologically-derived surgical mesh over time in a rodent full thickness abdominal wall defect. ( 27619242 )
2016
26
Congenital Abdominal Wall Defects: Staged closure by Dual Mesh. ( 26793594 )
2016
27
Reconstruction of an abdominal wall defect with biologic mesh after resection of a desmoid tumor in a patient with a Gardner's syndrome. ( 27538186 )
2016
28
Repair of Postoperative Abdominal Hernia in a Child with Congenital Omphalocele Using Porcine Dermal Matrix. ( 27110247 )
2016
29
Combined Use of an Anterolateral Thigh Flap and Superficial Inferior Epigastric Artery Flap for Reconstruction of an Extensive Abdominal Wall Defect. ( 27975026 )
2016
30
[Reducing invasiveness of laparoscopic surgery using natural orifices and abdominal wall defects for extraction of the specimen]. ( 25819148 )
2015
31
Simultaneous abdominal wall defect repair and Tenckhoff catheter placement in candidates for peritoneal dialysis. ( 26621104 )
2015
32
Complex abdominal wall defect reconstruction using a latissimus dorsi free flap with mesh after malignant tumor resection. ( 26037038 )
2015
33
Bacterial adhesion to biological versus polymer prosthetic materials used in abdominal wall defect repair: do these meshes show any differences in vitro? ( 25862028 )
2015
34
The use of a biological graft for the closure of large abdominal wall defects following excision of soft tissue tumours. ( 26109681 )
2015
35
Intraperitoneal microdialysis in the postoperative surveillance of infants undergoing surgery for congenital abdominal wall defect: A pilot study. ( 25783347 )
2015
36
Effects of nitrofurazone on correction of abdominal wall defect treated with polypropylene mesh involved by fibrous tissue. ( 26560427 )
2015
37
Use of surgical mesh of different compositions in the correction of the abdominal wall defect in rats. ( 26648152 )
2015
38
Urinary bladder herniation through a caudoventral abdominal wall defect in a mature cat. ( 26347198 )
2015
39
A successful early gore-tex reconstruction of an abdominal wall defect in a neonate with Cantrell pentalogy: a case report and literature review. ( 25678967 )
2015
40
Squamous cell carcinoma arising from abdominal wall defect lesion complicated with cloacal exstrophy. ( 25878926 )
2015
41
A randomized controlled experimental study comparing chitosan coated polypropylene mesh and Proceeda8c mesh for abdominal wall defect closure. ( 26594357 )
2015
42
Combined therapy of NPWT and bipedicled flap as an alternative approach for giant abdominal wall defect with significant visceral edema: report of a case. ( 27252963 )
2015
43
Severe abdominal wall defect leading to dehiscence in focal dermal hypoplasia (Goltz syndrome). ( 25751343 )
2015
44
Use of small intestinal submucosal and acellular dermal matrix grafts in giant omphaloceles in neonates and a rabbit abdominal wall defect model. ( 26364879 )
2015
45
Modern reconstructive techniques for abdominal wall defects after oncologic resection. ( 25371050 )
2015
46
A novel approach to reconstruct a large full thickness abdominal wall defect: successful treatment with MatriDermAr and Split. ( 25041311 )
2014
47
Carbon nanotubes as VEGF carriers to improve the early vascularization of porcine small intestinal submucosa in abdominal wall defect repair. ( 24648727 )
2014
48
Inflammatory reaction and tensile strength of the abdominal wall after an implant of polypropylene mesh and polypropylene/poliglecaprone mesh for abdominal wall defect treatment in rats. ( 25185056 )
2014
49
Reconstruction of full thickness abdominal wall defect following tumor resection: a case report. ( 25033593 )
2014
50
Reconstruction of large-size abdominal wall defect using biodegradable poly-p-dioxanone mesh: an experimental canine study. ( 24625138 )
2014

Variations for Abdominal Wall Defect

ClinVar genetic disease variations for Abdominal Wall Defect:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 46;X;t(X;10)(p11.2;q24.3) Translocation Uncertain significance

Expression for Abdominal Wall Defect

Search GEO for disease gene expression data for Abdominal Wall Defect.

Pathways for Abdominal Wall Defect

GO Terms for Abdominal Wall Defect

Sources for Abdominal Wall Defect

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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