MCID: ABD002
MIFTS: 42

Abducens Nerve Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Abducens Nerve Disease

MalaCards integrated aliases for Abducens Nerve Disease:

Name: Abducens Nerve Disease 12 15
Sixth Nerve Palsy 12 77 54
Abducens Nerve Diseases 45 74
Cranial Nerve Vi Palsy 54 30
Lateral Rectus Muscle Innervation Disorder 12
Lateral Rectus Muscle Denervation Paresis 12
Sixth or Abducens Nerve Palsy 12
Sixth Cranial Nerve Disorder 12
Cranial Mononeuropathy Vi 54
Sixth Cranial Nerve Palsy 54
Abducens Nerve Weakness 12
Vith Nerve Paralysis 12
Abducens Nerve Palsy 54
Vith Nerve Disorder 12
6th Nerve Palsy 54
Vi Nerve Palsy 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10865
ICD9CM 36 378.54
ICD10 34 H49.2
UMLS 74 C0271355

Summaries for Abducens Nerve Disease

NIH Rare Diseases : 54 Sixth nerve palsy is a nerve disorder that occurs when the sixth cranial nerve is damaged. The disorder prevents some of the muscles that control eye movement from working properly. Affected people cannot turn the eye outwards toward the ear. Other signs and symptoms may include double vision, headaches, and pain around the eye. Sixth nerve palsy may be caused by many things, including stroke, brain aneurysm, diabetic neuropathy, trauma, infections, inflammation, tumors, migraine headaches or intracranial pressure. Eye patches, glasses, corticosteroids, and/or botulinum toxin may be used to ease symptoms. Some people may not need any treatment, while others may need surgery.

MalaCards based summary : Abducens Nerve Disease, also known as sixth nerve palsy, is related to pituitary apoplexy and functioning pituitary adenoma. An important gene associated with Abducens Nerve Disease is ASPA (Aspartoacylase). Affiliated tissues include eye, brain and colon, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 77 Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve... more...

Related Diseases for Abducens Nerve Disease

Diseases related to Abducens Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 228)
# Related Disease Score Top Affiliating Genes
1 pituitary apoplexy 30.6 POMC PRL
2 functioning pituitary adenoma 30.3 POMC PRL
3 paralytic squint 29.8 FUT2 KANTR PRL SAMHD1
4 congenital abducens nerve palsy 11.8
5 diabetic neuropathy 11.3
6 cranial nerve palsy 10.9
7 sensory organ benign neoplasm 10.3 CA2 SYP
8 horner's syndrome 10.3
9 gangliocytoma 10.3 POMC SYP
10 pituitary infarct 10.3 POMC PRL
11 chiasmal syndrome 10.3 POMC PRL
12 pancreatic endocrine carcinoma 10.3 POMC SYP
13 adenohypophysitis 10.3 POMC PRL
14 hypothalamic disease 10.3 POMC PRL
15 olfactory nerve neoplasm 10.3 POMC SYP
16 male reproductive organ benign neoplasm 10.3 POMC SYP
17 pituitary carcinoma 10.3 POMC PRL
18 esotropia 10.3
19 empty sella syndrome 10.3 POMC PRL
20 tibial neuropathy 10.3 B2M POMC
21 meningitis 10.3
22 tarsal tunnel syndrome 10.3 B2M POMC
23 nelson syndrome 10.3 POMC PRL
24 sheehan syndrome 10.3 POMC PRL
25 hyperpituitarism 10.3 POMC PRL
26 obstructive hydrocephalus 10.3 PRL SYP
27 type 1 diabetes mellitus 6 10.3 FUT2 TCF4
28 spontaneous ocular nystagmus 10.2 FUT2 POMC
29 ovarian carcinosarcoma 10.2 FUT2 SYP
30 acth-secreting pituitary adenoma 10.2 POMC PRL
31 strabismus 10.2
32 aspirin allergy 10.2 CA2 SERPINC1
33 eclampsia 10.2
34 boomerang dysplasia 10.2 IVD SERPINC1
35 tsh producing pituitary tumor 10.2 POMC PRL
36 meningeal melanomatosis 10.2 B2M SYP
37 cervix small cell carcinoma 10.2 POMC SYP
38 multiple sclerosis 10.2
39 duane retraction syndrome 1 10.2
40 myeloma, multiple 10.2
41 monocular esotropia 10.2
42 herpes zoster 10.2
43 mechanical strabismus 10.2
44 herpes zoster ophthalmicus 10.2
45 diabetes insipidus, neurohypophyseal 10.2 POMC PRL
46 dental abscess 10.2 CA2 KANTR
47 trigeminal neuralgia 10.1
48 epidemic typhus 10.1
49 osteomyelitis 10.1
50 hemiplegia 10.1

Comorbidity relations with Abducens Nerve Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Abducens Nerve Disease:



Diseases related to Abducens Nerve Disease

Symptoms & Phenotypes for Abducens Nerve Disease

MGI Mouse Phenotypes related to Abducens Nerve Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ASAH1 ASPA B2M CA2 CD200 IVD
2 immune system MP:0005387 10.03 ASAH1 B2M CA2 CD200 FUT2 HNRNPL
3 hematopoietic system MP:0005397 10.02 ASAH1 ASPA B2M CD200 HNRNPL OGG1
4 mortality/aging MP:0010768 9.73 ASAH1 ASPA B2M CA2 HNRNPL IVD
5 liver/biliary system MP:0005370 9.7 ASAH1 B2M OGG1 POMC PRL SERPINC1
6 nervous system MP:0003631 9.36 ASAH1 ASPA B2M CA2 CD200 OGG1

Drugs & Therapeutics for Abducens Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070 Not Applicable
2 Effects of Ocular Electroacupuncture on Abducens Nerve Palsy Recruiting NCT03099460 Not Applicable
3 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
4 Improving Infant Hydrocephalus Outcomes in Uganda Not yet recruiting NCT03650101
5 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Abducens Nerve Disease

Cochrane evidence based reviews: abducens nerve diseases

Genetic Tests for Abducens Nerve Disease

Genetic tests related to Abducens Nerve Disease:

# Genetic test Affiliating Genes
1 Cranial Nerve Vi Palsy 30

Anatomical Context for Abducens Nerve Disease

MalaCards organs/tissues related to Abducens Nerve Disease:

42
Eye, Brain, Colon, Breast, Spinal Cord, Prostate

Publications for Abducens Nerve Disease

Articles related to Abducens Nerve Disease:

(show top 50) (show all 218)
# Title Authors Year
1
Petroclival Meningioma Presenting With an Ipsilateral Sixth Nerve Palsy and a Contralateral Homonymous Quadrantanopia: A Unique and Topographically Localizing Syndrome. ( 30664101 )
2019
2
Augmented superior rectus transposition procedure in Duane retraction syndrome compared with sixth nerve palsy. ( 29299740 )
2018
3
Adenoid cystic carcinoma of the hard palate presenting as ipsilateral sixth nerve palsy. ( 30038189 )
2018
4
Acute Transient Sixth Nerve Palsy in Chediak-Higashi Syndrome. ( 30180240 )
2018
5
A modified vertical muscle transposition for the treatment of large-angle esotropia due to sixth nerve palsy. ( 29985743 )
2018
6
Application of SRT plus MR recession in supra-maximal esotropia from chronic sixth nerve palsy. ( 30182295 )
2018
7
Botulinum toxin augmentation as a sequential procedure for residual esotropia in traumatic sixth nerve palsy. ( 30588442 )
2018
8
A Modified Surgical Technique to Treat Strabismus in Complete Sixth Nerve Palsy. ( 30196519 )
2018
9
White scarlike lesions in a female infant with bilious emesis and sixth nerve palsy. ( 29575076 )
2018
10
Bilateral superior rectus transposition and medial rectus recession for bilateral sixth nerve palsy. ( 29577099 )
2018
11
May the Inferior Petrosal Sinus Recanalization During Endovascular Treatment for Carotid-Cavernous Fistulas Increase the Risk of Sixth Nerve Palsy? ( 29730099 )
2018
12
Successful surgical management of sixth nerve palsy by transposition of a previously snapped and retrieved inferior rectus muscle. ( 30197960 )
2018
13
Bilateral Sixth Nerve Palsy and Nasal Voice in Two Sisters as a Variant of Guillan-Barré Syndrome. ( 30258478 )
2018
14
Augmented vertical recti transposition with intraoperative botulinum toxin for complete and chronic sixth nerve palsy. ( 27813529 )
2017
15
Isolated sixth nerve palsy: An unusual manifestation of preeclampsia. ( 28869047 )
2017
16
Sixth nerve palsy following botulinum toxin injection for facial rejuvenation. ( 27558865 )
2017
17
Unilateral sixth nerve palsy. ( 28043726 )
2017
18
Outcomes After Superior Rectus Transposition and Medial Rectus Recession Versus Vertical Recti Transposition for Sixth Nerve Palsy. ( 28249714 )
2017
19
Sixth Nerve Palsy from Cholesterol Granuloma of the Petrous Apex. ( 28261154 )
2017
20
Early Onset Sixth-Nerve Palsy with Eccentric Fixation. ( 28904218 )
2017
21
Pneumocephalus and Sixth Nerve Palsy after Epidural Steroid Injection: Case Report and Review of the Literature. ( 28987313 )
2017
22
Congenital sixth nerve palsy with associated anomalies. ( 29044089 )
2017
23
Benign Recurrent Sixth Nerve Palsy in a Child. ( 29445557 )
2017
24
Double Augmented Vertical Rectus Transposition for Large-Angle Esotropia Due to Sixth Nerve Palsy. ( 27537250 )
2016
25
Sixth Nerve Palsy in Paediatric Intracranial Hypertension. ( 27928378 )
2016
26
Isolated sixth nerve palsy after intravitreal ranibizumab injection. ( 26340018 )
2016
27
Central pontine myelinolysis presenting as isolated sixth nerve palsy in third trimester of pregnancy. ( 25745319 )
2015
28
Varicella vasculopathy and chronic suppurative otitis media: Differential diagnosis for isolated sixth nerve palsy. ( 26655013 )
2015
29
Maffucci syndrome and intracranial chondrosarcomas: a case report featuring spontaneous resolution of sixth nerve palsy. ( 24978479 )
2015
30
Recurrent Isolated Sixth Nerve Palsy in Relapsing-Remitting Chronic Inflammatory Demyelinating Polyneuropathy. ( 26301375 )
2015
31
Ocular Neuromyotonia Noted after Recent Botulinum Toxin Injection for Sixth Nerve Palsy Following Resection of a Posterior Fossa Skull Base Meningioma. ( 27928330 )
2015
32
Plasmacytoma of the Clivus Presenting as Bilateral Sixth Nerve Palsy. ( 26251795 )
2015
33
Idiopathic sixth nerve palsy after bimaxillary surgery: a complication or a sequential pathology independent from surgery? ( 25469898 )
2015
34
Treatment of Sixth Nerve Palsy. ( 26214719 )
2015
35
Anterior segment ischemia following Hummelsheim procedure in a case of sixth nerve palsy. ( 26265650 )
2015
36
Relapsing-Remitting Sixth Nerve Palsy in Association with Ollier's Disease. ( 27928339 )
2015
37
The diagnostic yield of neuroimaging in sixth nerve palsy--Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1. ( 25449936 )
2014
38
Benign recurrent sixth nerve palsy in an infant. ( 25608226 )
2014
39
Functional and Motor Outcomes of Strabismus Surgery for Chronic Isolated Adult Sixth Nerve Palsy. ( 27928319 )
2014
40
Sixth nerve palsy associated with obstruction in Dorello's canal, accompanied by nodular type muscular sarcoidosis. ( 24930400 )
2014
41
Multiple sclerosis causing a partial sixth nerve palsy. ( 25267832 )
2014
42
Benign recurrent sixth nerve palsy in an infant. ( 25347080 )
2014
43
Malignant transformation of a Schneiderian papilloma presenting with isolated sixth nerve palsy. ( 23244315 )
2013
44
The role of neuroimaging in the evaluation process of children with isolated sixth nerve palsy. ( 23001023 )
2013
45
Prognosis for sixth nerve palsy arising from paranasal sinus disease. ( 24119609 )
2013
46
Bevacizumab-induced transient sixth nerve palsy in ovarian cancer: A case report. ( 24188139 )
2013
47
Vertical muscle transposition augmented with lateral fixation (Foster) suture for Duane syndrome and sixth nerve palsy. ( 23907625 )
2013
48
Isolated sixth nerve palsy from hemorrhage of a pontine cavernous malformation. ( 22743823 )
2012
49
Superior rectus transposition and medial rectus recession for Duane syndrome and sixth nerve palsy. ( 22332212 )
2012
50
Cluster headache associated with a sixth nerve palsy: a case report. ( 20670995 )
2011

Variations for Abducens Nerve Disease

Expression for Abducens Nerve Disease

Search GEO for disease gene expression data for Abducens Nerve Disease.

Pathways for Abducens Nerve Disease

GO Terms for Abducens Nerve Disease

Molecular functions related to Abducens Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 ASPA B2M SAMHD1 SERPINC1 SYP TCF4

Sources for Abducens Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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