MCID: ABD002
MIFTS: 41

Abducens Nerve Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Abducens Nerve Disease

MalaCards integrated aliases for Abducens Nerve Disease:

Name: Abducens Nerve Disease 12 15
Sixth Nerve Palsy 12 76 53
Abducens Nerve Diseases 44 73
Cranial Nerve Vi Palsy 53 29
Lateral Rectus Muscle Innervation Disorder 12
Lateral Rectus Muscle Denervation Paresis 12
Sixth or Abducens Nerve Palsy 12
Sixth Cranial Nerve Disorder 12
Cranial Mononeuropathy Vi 53
Sixth Cranial Nerve Palsy 53
Abducens Nerve Weakness 12
Vith Nerve Paralysis 12
Abducens Nerve Palsy 53
Vith Nerve Disorder 12
6th Nerve Palsy 53
Abducens Palsy 44
Vi Nerve Palsy 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10865
ICD10 33 H49.2
ICD9CM 35 378.54
UMLS 73 C0271355

Summaries for Abducens Nerve Disease

NIH Rare Diseases : 53 Sixth nerve palsy is a nerve disorder that occurs when the sixth cranial nerve is damaged. The disorder prevents some of the muscles that control eye movement from working properly. Affected people cannot turn the eye outwards toward the ear. Other signs and symptoms may include double vision, headaches, and pain around the eye. Sixth nerve palsy may be caused by many things, including stroke, brain aneurysm, diabetic neuropathy, trauma, infections, inflammation, tumors, migraine headaches or intracranial pressure. Eye patches, glasses, corticosteroids, and/or botulinum toxin may be used to ease symptoms. Some people may not need any treatment, while others may need surgery.

MalaCards based summary : Abducens Nerve Disease, also known as sixth nerve palsy, is related to cranial nerve palsy and pituitary apoplexy. An important gene associated with Abducens Nerve Disease is CHN1 (Chimerin 1). Affiliated tissues include eye, brain and colon, and related phenotypes are behavior/neurological and hematopoietic system

Wikipedia : 76 Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve... more...

Related Diseases for Abducens Nerve Disease

Diseases related to Abducens Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 220)
# Related Disease Score Top Affiliating Genes
1 cranial nerve palsy 31.8 CHN1 ITM2C
2 pituitary apoplexy 30.3 PRL POMC
3 functioning pituitary adenoma 30.1 POMC PRL
4 paralytic squint 29.9 SAMHD1 PRL KANTR CHN1
5 hypertropia 29.9 SAMHD1 KANTR CHN1
6 abducens palsy 12.5
7 mental retardation, skeletal dysplasia, and abducens palsy 12.3
8 congenital abducens nerve palsy 11.7
9 diabetic neuropathy 11.3
10 ophthalmoplegia totalis with ptosis and miosis 11.2
11 horner's syndrome 10.3
12 strabismus 10.2
13 meningitis 10.2
14 fourth cranial nerve palsy 10.2 PRL CHN1
15 myeloma, multiple 10.2
16 alternating esotropia 10.1 KANTR CHN1
17 accommodative esotropia 10.1 KANTR CHN1
18 oculomotor nerve paralysis 10.1 CHN1 KANTR
19 gangliocytoma 10.1 SYP POMC
20 third cranial nerve disease 10.1 CHN1 KANTR
21 pancreatic endocrine carcinoma 10.1 POMC SYP
22 epidemic typhus 10.1
23 hemiplegia 10.1
24 scrub typhus 10.1
25 optic perineuritis 10.1
26 olfactory nerve neoplasm 10.1 POMC SYP
27 sinusitis 10.1
28 thrombosis 10.1
29 intracranial hypotension 10.1
30 male reproductive organ benign neoplasm 10.1 POMC SYP
31 pituitary infarct 10.1 PRL POMC
32 chiasmal syndrome 10.1 PRL POMC
33 adenohypophysitis 10.1 PRL POMC
34 hypothalamic disease 10.1 PRL POMC
35 pituitary carcinoma 10.1 POMC PRL
36 empty sella syndrome 10.1 POMC PRL
37 nelson syndrome 10.1 POMC PRL
38 sheehan syndrome 10.1 POMC PRL
39 cervix small cell carcinoma 10.1 POMC SYP
40 hyperpituitarism 10.1 POMC PRL
41 acth-secreting pituitary adenoma 10.1 POMC PRL
42 cranial nerve malignant neoplasm 10.1 POMC SYP
43 nasopharyngeal carcinoma 10.1
44 chronic inflammatory demyelinating polyneuropathy 10.1
45 monocular esotropia 10.1
46 meningoencephalitis 10.1
47 arteriovenous malformation 10.1
48 polyneuropathy 10.1
49 plasmacytoma 10.1
50 demyelinating polyneuropathy 10.1

Comorbidity relations with Abducens Nerve Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Abducens Nerve Disease:



Diseases related to Abducens Nerve Disease

Symptoms & Phenotypes for Abducens Nerve Disease

MGI Mouse Phenotypes related to Abducens Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.06 ASAH1 CD200 CHN1 OGG1 POMC PRL
2 hematopoietic system MP:0005397 9.97 ASAH1 CD200 CHN1 HNRNPL OGG1 POMC
3 immune system MP:0005387 9.97 ASAH1 CD200 HNRNPL OGG1 POMC PRL
4 mortality/aging MP:0010768 9.9 ASAH1 CHN1 HNRNPL ITM2C IVD OGG1
5 liver/biliary system MP:0005370 9.73 ASAH1 OGG1 POMC PRL PTH1R STAB2
6 neoplasm MP:0002006 9.35 OGG1 POMC PRL PTH1R STAB2
7 nervous system MP:0003631 9.28 ASAH1 CD200 CHN1 OGG1 POMC PRL

Drugs & Therapeutics for Abducens Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070 Not Applicable
2 Effects of Ocular Electroacupuncture on Abducens Nerve Palsy Recruiting NCT03099460 Not Applicable
3 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
4 Improving Infant Hydrocephalus Outcomes in Uganda Not yet recruiting NCT03650101

Search NIH Clinical Center for Abducens Nerve Disease

Cochrane evidence based reviews: abducens nerve diseases

Genetic Tests for Abducens Nerve Disease

Genetic tests related to Abducens Nerve Disease:

# Genetic test Affiliating Genes
1 Cranial Nerve Vi Palsy 29

Anatomical Context for Abducens Nerve Disease

MalaCards organs/tissues related to Abducens Nerve Disease:

41
Eye, Brain, Colon, Prostate, Pituitary, Thyroid, B Cells

Publications for Abducens Nerve Disease

Articles related to Abducens Nerve Disease:

(show top 50) (show all 216)
# Title Authors Year
1
Augmented superior rectus transposition procedure in Duane retraction syndrome compared with sixth nerve palsy. ( 29299740 )
2018
2
Adenoid cystic carcinoma of the hard palate presenting as ipsilateral sixth nerve palsy. ( 30038189 )
2018
3
Acute Transient Sixth Nerve Palsy in Chediak-Higashi Syndrome. ( 30180240 )
2018
4
A modified vertical muscle transposition for the treatment of large-angle esotropia due to sixth nerve palsy. ( 29985743 )
2018
5
Application of SRT plus MR recession in supra-maximal esotropia from chronic sixth nerve palsy. ( 30182295 )
2018
6
A Modified Surgical Technique to Treat Strabismus in Complete Sixth Nerve Palsy. ( 30196519 )
2018
7
White scarlike lesions in a female infant with bilious emesis and sixth nerve palsy. ( 29575076 )
2018
8
Bilateral superior rectus transposition and medial rectus recession for bilateral sixth nerve palsy. ( 29577099 )
2018
9
May the Inferior Petrosal Sinus Recanalization During Endovascular Treatment for Carotid-Cavernous Fistulas Increase the Risk of Sixth Nerve Palsy? ( 29730099 )
2018
10
Successful surgical management of sixth nerve palsy by transposition of a previously snapped and retrieved inferior rectus muscle. ( 30197960 )
2018
11
Bilateral Sixth Nerve Palsy and Nasal Voice in Two Sisters as a Variant of Guillan-Barré Syndrome. ( 30258478 )
2018
12
Augmented vertical recti transposition with intraoperative botulinum toxin for complete and chronic sixth nerve palsy. ( 27813529 )
2017
13
Sixth nerve palsy following botulinum toxin injection for facial rejuvenation. ( 27558865 )
2017
14
Unilateral sixth nerve palsy. ( 28043726 )
2017
15
Outcomes After Superior Rectus Transposition and Medial Rectus Recession Versus Vertical Recti Transposition for Sixth Nerve Palsy. ( 28249714 )
2017
16
Sixth Nerve Palsy from Cholesterol Granuloma of the Petrous Apex. ( 28261154 )
2017
17
Isolated sixth nerve palsy: An unusual manifestation of preeclampsia. ( 28869047 )
2017
18
Early Onset Sixth-Nerve Palsy with Eccentric Fixation. ( 28904218 )
2017
19
Pneumocephalus and Sixth Nerve Palsy after Epidural Steroid Injection: Case Report and Review of the Literature. ( 28987313 )
2017
20
Congenital sixth nerve palsy with associated anomalies. ( 29044089 )
2017
21
Benign Recurrent Sixth Nerve Palsy in a Child. ( 29445557 )
2017
22
Double Augmented Vertical Rectus Transposition for Large-Angle Esotropia Due to Sixth Nerve Palsy. ( 27537250 )
2016
23
Sixth Nerve Palsy in Paediatric Intracranial Hypertension. ( 27928378 )
2016
24
Isolated sixth nerve palsy after intravitreal ranibizumab injection. ( 26340018 )
2016
25
Central pontine myelinolysis presenting as isolated sixth nerve palsy in third trimester of pregnancy. ( 25745319 )
2015
26
Varicella vasculopathy and chronic suppurative otitis media: Differential diagnosis for isolated sixth nerve palsy. ( 26655013 )
2015
27
Maffucci syndrome and intracranial chondrosarcomas: a case report featuring spontaneous resolution of sixth nerve palsy. ( 24978479 )
2015
28
Recurrent Isolated Sixth Nerve Palsy in Relapsing-Remitting Chronic Inflammatory Demyelinating Polyneuropathy. ( 26301375 )
2015
29
Ocular Neuromyotonia Noted after Recent Botulinum Toxin Injection for Sixth Nerve Palsy Following Resection of a Posterior Fossa Skull Base Meningioma. ( 27928330 )
2015
30
Plasmacytoma of the Clivus Presenting as Bilateral Sixth Nerve Palsy. ( 26251795 )
2015
31
Idiopathic sixth nerve palsy after bimaxillary surgery: a complication or a sequential pathology independent from surgery? ( 25469898 )
2015
32
Treatment of Sixth Nerve Palsy. ( 26214719 )
2015
33
Anterior segment ischemia following Hummelsheim procedure in a case of sixth nerve palsy. ( 26265650 )
2015
34
Relapsing-Remitting Sixth Nerve Palsy in Association with Ollier's Disease. ( 27928339 )
2015
35
The diagnostic yield of neuroimaging in sixth nerve palsy--Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1. ( 25449936 )
2014
36
Benign recurrent sixth nerve palsy in an infant. ( 25608226 )
2014
37
Functional and Motor Outcomes of Strabismus Surgery for Chronic Isolated Adult Sixth Nerve Palsy. ( 27928319 )
2014
38
Sixth nerve palsy associated with obstruction in Dorello's canal, accompanied by nodular type muscular sarcoidosis. ( 24930400 )
2014
39
Multiple sclerosis causing a partial sixth nerve palsy. ( 25267832 )
2014
40
Benign recurrent sixth nerve palsy in an infant. ( 25347080 )
2014
41
Malignant transformation of a Schneiderian papilloma presenting with isolated sixth nerve palsy. ( 23244315 )
2013
42
The role of neuroimaging in the evaluation process of children with isolated sixth nerve palsy. ( 23001023 )
2013
43
Prognosis for sixth nerve palsy arising from paranasal sinus disease. ( 24119609 )
2013
44
Bevacizumab-induced transient sixth nerve palsy in ovarian cancer: A case report. ( 24188139 )
2013
45
Vertical muscle transposition augmented with lateral fixation (Foster) suture for Duane syndrome and sixth nerve palsy. ( 23907625 )
2013
46
Isolated sixth nerve palsy from hemorrhage of a pontine cavernous malformation. ( 22743823 )
2012
47
Superior rectus transposition and medial rectus recession for Duane syndrome and sixth nerve palsy. ( 22332212 )
2012
48
Cluster headache associated with a sixth nerve palsy: a case report. ( 20670995 )
2011
49
Rhinocerebral mucormycosis with isolated sixth nerve palsy in an immunocompetent patient. ( 22299566 )
2011
50
Sixth nerve palsy as the presenting symptom of metastatic colon carcinoma. ( 20941638 )
2011

Variations for Abducens Nerve Disease

Expression for Abducens Nerve Disease

Search GEO for disease gene expression data for Abducens Nerve Disease.

Pathways for Abducens Nerve Disease

GO Terms for Abducens Nerve Disease

Molecular functions related to Abducens Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 8.8 PTH1R SYP TCF4

Sources for Abducens Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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