MCID: ABD002
MIFTS: 38

Abducens Nerve Disease

Categories: Eye diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Abducens Nerve Disease

MalaCards integrated aliases for Abducens Nerve Disease:

Name: Abducens Nerve Disease 12 15
Sixth Nerve Palsy 12 73 20
Abducens Nerve Diseases 44 70
Cranial Nerve Vi Palsy 20 29
Lateral Rectus Muscle Innervation Disorder 12
Lateral Rectus Muscle Denervation Paresis 12
Sixth or Abducens Nerve Palsy 12
Sixth Cranial Nerve Disorder 12
Cranial Mononeuropathy Vi 20
Sixth Cranial Nerve Palsy 20
Abducens Nerve Weakness 12
Abducens Nerve Disorder 6
Vith Nerve Paralysis 12
Abducens Nerve Palsy 20
Vith Nerve Disorder 12
6th Nerve Palsy 20
Vi Nerve Palsy 20

Classifications:



External Ids:

Disease Ontology 12 DOID:10865
MeSH 44 D020434
NCIt 50 C27593
SNOMED-CT 67 82373004
ICD10 32 H49.2
UMLS 70 C0271355

Summaries for Abducens Nerve Disease

GARD : 20 Sixth nerve palsy is a nerve disorder that occurs when the sixth cranial nerve is damaged. The disorder prevents some of the muscles that control eye movement from working properly. Affected people cannot turn the eye outwards toward the ear. Other signs and symptoms may include double vision, headaches, and pain around the eye. Sixth nerve palsy may be caused by many things, including stroke, brain aneurysm, diabetic neuropathy, trauma, infections, inflammation, tumors, migraine headaches or intracranial pressure. Eye patches, glasses, corticosteroids, and/or botulinum toxin may be used to ease symptoms. Some people may not need any treatment, while others may need surgery.

MalaCards based summary : Abducens Nerve Disease, also known as sixth nerve palsy, is related to lemierre's syndrome and pituitary apoplexy. An important gene associated with Abducens Nerve Disease is CRP (C-Reactive Protein), and among its related pathways/superpathways are Development_Leptin signaling via JAK/STAT and MAPK cascades and Antipsychotics Pathway (Metabolic Side Effects), Pharmacodynamics. Affiliated tissues include eye, pituitary and spinal cord, and related phenotype is nervous system.

Wikipedia : 73 Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve... more...

Related Diseases for Abducens Nerve Disease

Diseases related to Abducens Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 504)
# Related Disease Score Top Affiliating Genes
1 lemierre's syndrome 30.7 F2 CRP
2 pituitary apoplexy 30.6 PRL POMC
3 mastoiditis 30.6 SERPINC1 F2 CRP
4 pituitary tumors 30.5 PRL POMC
5 neurosarcoidosis 30.5 CRP AQP4
6 hypopituitarism 30.3 PRL POMC CRP
7 thrombophlebitis 30.3 SERPINC1 F2 CRP
8 multiple cranial nerve palsy 30.2 MUSK CRP
9 sagittal sinus thrombosis 30.2 SERPINC1 F2
10 intracranial hypertension 30.1 SERPINC1 PRL F2 AQP4
11 migraine with or without aura 1 30.1 PRL POMC F2 CRP
12 endocarditis 30.1 SERPINC1 F2 CRP
13 homocysteinemia 30.1 SERPINC1 F2 CRP
14 cavernous sinus thrombosis 30.1 SERPINC1 F2 CRP
15 miller fisher syndrome 30.0 MUSK AQP4
16 intracranial hypotension 30.0 SERPINC1 SCYL3 F2
17 intracranial hypertension, idiopathic 29.9 POMC F2 AQP4
18 cranial nerve palsy 29.9 SYP SERPINC1 PRL POMC CRP AQP4
19 obstructive hydrocephalus 29.9 SYP PRL AQP4
20 papilledema 29.7 SYP SERPINC1 F2 CRP AQP4
21 stroke, ischemic 29.7 SERPINC1 F2 CRP AQP4
22 cauda equina syndrome 29.7 SYP POMC F2 CRP
23 congenital abducens nerve palsy 11.4
24 diabetic neuropathy 11.3
25 monocular esotropia 10.7
26 esotropia 10.7
27 strabismus 10.7
28 mechanical strabismus 10.7
29 abducens palsy 10.4
30 horner's syndrome 10.4
31 thrombosis 10.4
32 myeloma, multiple 10.4
33 yemenite deaf-blind hypopigmentation syndrome 10.4
34 mediastinum teratoma 10.3 POMC CRP
35 hydrocephalus 10.3
36 tuberculous epididymitis 10.3 POMC CRP
37 blue toe syndrome 10.3 SERPINC1 CRP
38 cerebral arteritis 10.3 SERPINC1 CRP
39 epidemic typhus 10.3
40 meningitis 10.3
41 atypical depressive disorder 10.3 POMC CRP
42 adenohypophysitis 10.3 PRL POMC
43 tuberculum sellae meningioma 10.3 PRL POMC
44 sella turcica neoplasm 10.3 PRL POMC
45 nasopharyngeal carcinoma 10.3
46 meningioma, familial 10.3
47 intracranial meningioma 10.3
48 paralytic squint 10.3
49 secretory meningioma 10.3
50 lymphoplasmacyte-rich meningioma 10.3

Comorbidity relations with Abducens Nerve Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Abducens Nerve Disease:



Diseases related to Abducens Nerve Disease

Symptoms & Phenotypes for Abducens Nerve Disease

MGI Mouse Phenotypes related to Abducens Nerve Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 AQP4 CHN1 F2 MUSK POMC PRL

Drugs & Therapeutics for Abducens Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Randomized Trial of Ocular Electroacupuncture for Abducens Nerve Palsy Unknown status NCT03099460
2 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420

Search NIH Clinical Center for Abducens Nerve Disease

Cochrane evidence based reviews: abducens nerve diseases

Genetic Tests for Abducens Nerve Disease

Genetic tests related to Abducens Nerve Disease:

# Genetic test Affiliating Genes
1 Cranial Nerve Vi Palsy 29

Anatomical Context for Abducens Nerve Disease

MalaCards organs/tissues related to Abducens Nerve Disease:

40
Eye, Pituitary, Spinal Cord, Colon, Heart, Thyroid, Bone

Publications for Abducens Nerve Disease

Articles related to Abducens Nerve Disease:

(show top 50) (show all 585)
# Title Authors PMID Year
1
Anterior Petrosal [Kawase] Approach to Meckel's Cave Meningioma: 2-Dimensional Operative Video. 61
33475720 2021
2
Nonsecretory Recurrence of Multiple Myeloma Presenting as Sixth Nerve Palsy Secondary to Clival Plasmacytoma. 61
32235225 2021
3
Acute Sixth Nerve Palsy and Retinal Hemorrhages as the Presenting Features of Acute Lymphoblastic Leukemia. 61
32141979 2021
4
Superior Rectus Transposition and Medial Rectus Recession for Treatment of Duane Retraction Syndrome and Sixth Nerve Palsy. 61
33666529 2021
5
Sixth nerve palsy in pediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 infection. 61
33788823 2021
6
Acute-onset binocular diplopia in neurological unit: Aetiological factors and diagnostic assessment. 61
33788260 2021
7
Endoscope-Controlled Microsurgery of a Ruptured Middle Fossa Arachnoid Cyst. 61
33130131 2021
8
Fascicular Sixth Nerve Palsy as a Presenting Sign of Metastatic Ovarian Carcinoma. 61
33630778 2021
9
Visual acuity loss and sixth nerve palsy as the only manifestations of slit ventricle syndrome. 61
33478754 2021
10
Atypical presentations of idiopathic intracranial hypertension. 61
33767953 2021
11
Augmented superior rectus muscle transposition in management of defective ocular abduction. 61
33472581 2021
12
Lyme Disease in the Era of COVID-19: A Delayed Diagnosis and Risk for Complications. 61
33628543 2021
13
Isolated Compressive Sixth Nerve Palsy due to Multiple Intracranial Cavernomas. 61
33762789 2021
14
Neuro-Ophthalmic Manifestations of Mollaret Meningitis. 61
33417418 2021
15
Transient Bilateral Sixth Nerve Palsy: A Rare Sequela of Head Trauma. 61
33628673 2021
16
The diagnostic dilemma of a pregnant woman presenting with an isolated sixth nerve palsy: A case report. 61
33343697 2020
17
Clivus chordomas: Heterogeneous tumor extension requires adapted surgical approaches. 61
33091655 2020
18
[Severe right-sided cephalalgia with right sixth nerve palsy]. 61
33336307 2020
19
Hummelsheim procedure combined with medial rectus recession in complete sixth nerve palsy and esotropic Duane Retraction Syndrome. 61
33228408 2020
20
Diagnostic difficulties in a patient with multiple sclerosis who presents with cranial nerve palsies: an unusual complication of dental work. 61
33127721 2020
21
Metastatic Renal Cell Carcinoma Masquerading as a Sphenoid Wing Meningioma. 61
32251182 2020
22
Progressive sixth nerve palsy secondary to intracavernous arachnoid cyst and complicated by contralateral optic nerve sheath meningioma. 61
31155935 2020
23
Abducens Nerve Schwannoma: First Case to Be Treated With an Expanded Endonasal Approach. 61
32955349 2020
24
Intracavernous Internal Carotid Artery Aneurysm Presenting as Acute Diplopia: A Case Report. 61
32926687 2020
25
Sixth Nerve Palsy and Myocarditis as the Only Presenting Manifestation of Giant Cell Arteritis. 61
32868557 2020
26
Sphenoid sinus aspergilloma with sixth nerve palsy. 61
32075878 2020
27
Idiopathic intracranial hypertension: Update on diagnosis and management. 61
32675143 2020
28
Augmented vertical rectus transpositions: Intraoperative measurement of torsion following sequential muscle detachment. 61
32720807 2020
29
Spontaneous Intracranial Hypotension Followed by Intracranial Hypertension. 61
32618842 2020
30
Sixth cranial nerve palsy secondary to compression by dolichoectatic vertebrobasilar artery. 61
32636226 2020
31
Multiple intracranial aneurysms in a patient with type I Gaucher disease: a case report and literature review. 61
29334776 2020
32
Herpes Zoster Ophthalmicus with Unilateral Sixth Nerve Palsy. 61
31852560 2020
33
Sixth Nerve Palsy Secondary to Traumatic Carotid-Jugular Fistula. 61
32076449 2020
34
Vertical rectus muscle union combined with lateral rectus plication for complete abducens nerve palsy. 61
31646412 2020
35
Acquired Ocular Motor Palsy: Current Demographic and Etiological Profile. 61
31990742 2020
36
The Management of Childhood Intracranial Tumours and the Role of the Ophthalmologist. 61
32165896 2019
37
Sixth nerve palsy in sporadic Burkitt Lymphoma. 61
31737801 2019
38
Multifocal Stroke From Ozone Gas Emboli. 61
30741783 2019
39
Acute Isolated Sixth Nerve Palsy Caused by Unruptured Intradural Saccular Aneurysm. 61
31790372 2019
40
Bilateral sixth nerve palsies from carotid cavernous fistulas with transient worsening following transvenous embolisation. 61
31712243 2019
41
Isolated sixth nerve palsy: An unusual manifestation of preeclampsia. 61
28869047 2019
42
Posterior Inferior Cerebellar Artery Infarction Originating at C1-2 after C1-2 Fusion. 61
31720276 2019
43
Chronic Sixth Nerve Palsy due to Compression by the Anterior Inferior Cerebellar Artery. 61
31590701 2019
44
Isolated unilateral sixth nerve palsy in a patient with nasopharyngeal carcinoma. 61
31915737 2019
45
Nasopharyngeal carcinoma presenting as a sixth nerve palsy and Horner's syndrome. 61
31604725 2019
46
Petroclival Meningioma Presenting With an Ipsilateral Sixth Nerve Palsy and a Contralateral Homonymous Quadrantanopia: A Unique and Topographically Localizing Syndrome. 61
30664101 2019
47
Insidious onset of headache, diplopia and Horner's syndrome: a rare case of petrous bone osteomyelitis. 61
31537596 2019
48
Utility of Magnetic Resonance Imaging Features for Improving the Diagnosis of Idiopathic Intracranial Hypertension Without Papilledema. 61
30829949 2019
49
Congenital Cranial Dysinnervation Disorder: An Unusual Phenotype With Multiple Cranial Neuropathies and Novel Neuroimaging Findings. 61
31008839 2019
50
Resection of Pediatric Trigeminal Schwannoma Using Minimally Invasive Approach: Case Report, Literature Review, and Operative Video. 61
31009782 2019

Variations for Abducens Nerve Disease

Expression for Abducens Nerve Disease

Search GEO for disease gene expression data for Abducens Nerve Disease.

Pathways for Abducens Nerve Disease

Pathways related to Abducens Nerve Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.43 POMC CRP
2 9.92 PRL POMC

GO Terms for Abducens Nerve Disease

Cellular components related to Abducens Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.43 SFTA3 SERPINC1 PRL POMC F2 CRP
2 extracellular region GO:0005576 9.17 SFTA3 SERPINC1 PRL POMC F2 CRP

Biological processes related to Abducens Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of JAK-STAT cascade GO:0046427 9.16 PRL F2
2 regulation of blood coagulation GO:0030193 8.96 SERPINC1 F2
3 cellular protein metabolic process GO:0044267 8.92 SFTA3 SERPINC1 PRL F2

Sources for Abducens Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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