MCID: ABD002
MIFTS: 42

Abducens Nerve Disease

Categories: Eye diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Abducens Nerve Disease

MalaCards integrated aliases for Abducens Nerve Disease:

Name: Abducens Nerve Disease 12 15
Sixth Nerve Palsy 12 77 54
Abducens Nerve Diseases 45 74
Cranial Nerve Vi Palsy 54 30
Lateral Rectus Muscle Innervation Disorder 12
Lateral Rectus Muscle Denervation Paresis 12
Sixth or Abducens Nerve Palsy 12
Sixth Cranial Nerve Disorder 12
Cranial Mononeuropathy Vi 54
Sixth Cranial Nerve Palsy 54
Abducens Nerve Weakness 12
Vith Nerve Paralysis 12
Abducens Nerve Palsy 54
Vith Nerve Disorder 12
6th Nerve Palsy 54
Vi Nerve Palsy 54

Classifications:



External Ids:

Disease Ontology 12 DOID:10865
ICD9CM 36 378.54
ICD10 34 H49.2
UMLS 74 C0271355

Summaries for Abducens Nerve Disease

NIH Rare Diseases : 54 Sixth nerve palsy is a nerve disorder that occurs when the sixth cranial nerve is damaged. The disorder prevents some of the muscles that control eye movement from working properly. Affected people cannot turn the eye outwards toward the ear. Other signs and symptoms may include double vision, headaches, and pain around the eye. Sixth nerve palsy may be caused by many things, including stroke, brain aneurysm, diabetic neuropathy, trauma, infections, inflammation, tumors, migraine headaches or intracranial pressure. Eye patches, glasses, corticosteroids, and/or botulinum toxin may be used to ease symptoms. Some people may not need any treatment, while others may need surgery.

MalaCards based summary : Abducens Nerve Disease, also known as sixth nerve palsy, is related to pituitary apoplexy and functioning pituitary adenoma. An important gene associated with Abducens Nerve Disease is ASPA (Aspartoacylase). Affiliated tissues include eye, pituitary and brain, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 77 Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve... more...

Related Diseases for Abducens Nerve Disease

Diseases related to Abducens Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 pituitary apoplexy 30.7 POMC PRL
2 functioning pituitary adenoma 30.3 POMC PRL
3 paralytic squint 29.8 FUT2 KANTR PRL SAMHD1
4 congenital abducens nerve palsy 11.8
5 diabetic neuropathy 11.4
6 cranial nerve palsy 10.9
7 horner's syndrome 10.4
8 sensory organ benign neoplasm 10.3 CA2 SYP
9 gangliocytoma 10.3 POMC SYP
10 pituitary infarct 10.3 POMC PRL
11 chiasmal syndrome 10.3 POMC PRL
12 adenohypophysitis 10.3 POMC PRL
13 pancreatic endocrine carcinoma 10.3 POMC SYP
14 hypothalamic disease 10.3 POMC PRL
15 olfactory nerve neoplasm 10.3 POMC SYP
16 male reproductive organ benign neoplasm 10.3 POMC SYP
17 pituitary carcinoma 10.3 POMC PRL
18 monocular esotropia 10.3
19 esotropia 10.3
20 meningitis 10.3
21 empty sella syndrome 10.3 POMC PRL
22 tibial neuropathy 10.3 B2M POMC
23 tarsal tunnel syndrome 10.3 B2M POMC
24 nelson syndrome 10.3 POMC PRL
25 sheehan syndrome 10.3 POMC PRL
26 hyperpituitarism 10.3 POMC PRL
27 obstructive hydrocephalus 10.3 PRL SYP
28 spontaneous ocular nystagmus 10.2 FUT2 POMC
29 type 1 diabetes mellitus 6 10.2 FUT2 TCF4
30 strabismus 10.2
31 mechanical strabismus 10.2
32 ovarian carcinosarcoma 10.2 FUT2 SYP
33 acth-secreting pituitary adenoma 10.2 POMC PRL
34 aspirin allergy 10.2 CA2 SERPINC1
35 epidemic typhus 10.2
36 eclampsia 10.2
37 boomerang dysplasia 10.2 IVD SERPINC1
38 tsh producing pituitary tumor 10.2 POMC PRL
39 meningeal melanomatosis 10.2 B2M SYP
40 cervix small cell carcinoma 10.2 POMC SYP
41 multiple sclerosis 10.2
42 duane retraction syndrome 1 10.2
43 myeloma, multiple 10.2
44 herpes zoster 10.2
45 herpes zoster ophthalmicus 10.2
46 dental abscess 10.2 CA2 KANTR
47 diabetes insipidus, neurohypophyseal 10.2 POMC PRL
48 trigeminal neuralgia 10.1
49 osteomyelitis 10.1
50 hemiplegia 10.1

Comorbidity relations with Abducens Nerve Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Abducens Nerve Disease:



Diseases related to Abducens Nerve Disease

Symptoms & Phenotypes for Abducens Nerve Disease

MGI Mouse Phenotypes related to Abducens Nerve Disease:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.06 ASAH1 ASPA B2M CA2 CD200 IVD
2 immune system MP:0005387 10.03 ASAH1 B2M CA2 CD200 FUT2 HNRNPL
3 hematopoietic system MP:0005397 10.02 ASAH1 ASPA B2M CD200 HNRNPL OGG1
4 mortality/aging MP:0010768 9.73 ASAH1 ASPA B2M CA2 HNRNPL IVD
5 liver/biliary system MP:0005370 9.7 ASAH1 B2M OGG1 POMC PRL SERPINC1
6 nervous system MP:0003631 9.36 ASAH1 ASPA B2M CA2 CD200 OGG1

Drugs & Therapeutics for Abducens Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070 Not Applicable
2 Effects of Ocular Electroacupuncture on Abducens Nerve Palsy Recruiting NCT03099460 Not Applicable
3 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
4 Improving Infant Hydrocephalus Outcomes in Uganda Not yet recruiting NCT03650101
5 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Abducens Nerve Disease

Cochrane evidence based reviews: abducens nerve diseases

Genetic Tests for Abducens Nerve Disease

Genetic tests related to Abducens Nerve Disease:

# Genetic test Affiliating Genes
1 Cranial Nerve Vi Palsy 30

Anatomical Context for Abducens Nerve Disease

MalaCards organs/tissues related to Abducens Nerve Disease:

42
Eye, Pituitary, Brain, Prostate, Colon, Breast, Spinal Cord

Publications for Abducens Nerve Disease

Articles related to Abducens Nerve Disease:

(show top 50) (show all 220)
# Title Authors Year
1
Application of SRT plus MR recession in supra-maximal esotropia from chronic sixth nerve palsy. ( 30182295 )
2019
2
Petroclival Meningioma Presenting With an Ipsilateral Sixth Nerve Palsy and a Contralateral Homonymous Quadrantanopia: A Unique and Topographically Localizing Syndrome. ( 30664101 )
2019
3
Purtscher's retinopathy in one and sixth nerve palsy in the other eye following head trauma. ( 30984509 )
2019
4
A modified vertical muscle transposition for the treatment of large-angle esotropia due to sixth nerve palsy. ( 29985743 )
2018
5
Botulinum toxin augmentation as a sequential procedure for residual esotropia in traumatic sixth nerve palsy. ( 30588442 )
2018
6
White scarlike lesions in a female infant with bilious emesis and sixth nerve palsy. ( 29575076 )
2018
7
Bilateral superior rectus transposition and medial rectus recession for bilateral sixth nerve palsy. ( 29577099 )
2018
8
May the Inferior Petrosal Sinus Recanalization During Endovascular Treatment for Carotid-Cavernous Fistulas Increase the Risk of Sixth Nerve Palsy? ( 29730099 )
2018
9
Successful surgical management of sixth nerve palsy by transposition of a previously snapped and retrieved inferior rectus muscle. ( 30197960 )
2018
10
Bilateral Sixth Nerve Palsy and Nasal Voice in Two Sisters as a Variant of Guillan-Barré Syndrome. ( 30258478 )
2018
11
A Modified Surgical Technique to Treat Strabismus in Complete Sixth Nerve Palsy. ( 30196519 )
2018
12
Augmented superior rectus transposition procedure in Duane retraction syndrome compared with sixth nerve palsy. ( 29299740 )
2018
13
Acute Transient Sixth Nerve Palsy in Chediak-Higashi Syndrome. ( 30180240 )
2018
14
Adenoid cystic carcinoma of the hard palate presenting as ipsilateral sixth nerve palsy. ( 30038189 )
2018
15
Isolated sixth nerve palsy: An unusual manifestation of preeclampsia. ( 28869047 )
2017
16
Sixth nerve palsy following botulinum toxin injection for facial rejuvenation. ( 27558865 )
2017
17
Augmented vertical recti transposition with intraoperative botulinum toxin for complete and chronic sixth nerve palsy. ( 27813529 )
2017
18
Unilateral sixth nerve palsy. ( 28043726 )
2017
19
Outcomes After Superior Rectus Transposition and Medial Rectus Recession Versus Vertical Recti Transposition for Sixth Nerve Palsy. ( 28249714 )
2017
20
Sixth Nerve Palsy from Cholesterol Granuloma of the Petrous Apex. ( 28261154 )
2017
21
Early Onset Sixth-Nerve Palsy with Eccentric Fixation. ( 28904218 )
2017
22
Pneumocephalus and Sixth Nerve Palsy after Epidural Steroid Injection: Case Report and Review of the Literature. ( 28987313 )
2017
23
Congenital sixth nerve palsy with associated anomalies. ( 29044089 )
2017
24
Benign Recurrent Sixth Nerve Palsy in a Child. ( 29445557 )
2017
25
Double Augmented Vertical Rectus Transposition for Large-Angle Esotropia Due to Sixth Nerve Palsy. ( 27537250 )
2016
26
Sixth Nerve Palsy in Paediatric Intracranial Hypertension. ( 27928378 )
2016
27
Isolated sixth nerve palsy after intravitreal ranibizumab injection. ( 26340018 )
2016
28
Bevacizumab-induced transient sixth nerve palsy in ovarian cancer: A case report. ( 24188139 )
2016
29
Central pontine myelinolysis presenting as isolated sixth nerve palsy in third trimester of pregnancy. ( 25745319 )
2015
30
Sixth nerve palsy + ipsilateral Horner's Syndrome = Parkinson's Syndrome. ( 25859142 )
2015
31
Ocular Neuromyotonia Noted after Recent Botulinum Toxin Injection for Sixth Nerve Palsy Following Resection of a Posterior Fossa Skull Base Meningioma. ( 27928330 )
2015
32
Plasmacytoma of the Clivus Presenting as Bilateral Sixth Nerve Palsy. ( 26251795 )
2015
33
Treatment of Sixth Nerve Palsy. ( 26214719 )
2015
34
Anterior segment ischemia following Hummelsheim procedure in a case of sixth nerve palsy. ( 26265650 )
2015
35
Relapsing-Remitting Sixth Nerve Palsy in Association with Ollier's Disease. ( 27928339 )
2015
36
Idiopathic sixth nerve palsy after bimaxillary surgery: a complication or a sequential pathology independent from surgery? ( 25469898 )
2015
37
Maffucci syndrome and intracranial chondrosarcomas: a case report featuring spontaneous resolution of sixth nerve palsy. ( 24978479 )
2015
38
Varicella vasculopathy and chronic suppurative otitis media: Differential diagnosis for isolated sixth nerve palsy. ( 26655013 )
2015
39
Recurrent Isolated Sixth Nerve Palsy in Relapsing-Remitting Chronic Inflammatory Demyelinating Polyneuropathy. ( 26301375 )
2015
40
The diagnostic yield of neuroimaging in sixth nerve palsy--Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1. ( 25449936 )
2014
41
Functional and Motor Outcomes of Strabismus Surgery for Chronic Isolated Adult Sixth Nerve Palsy. ( 27928319 )
2014
42
Benign recurrent sixth nerve palsy in an infant. ( 25608226 )
2014
43
Benign recurrent sixth nerve palsy in an infant. ( 25347080 )
2014
44
Multiple sclerosis causing a partial sixth nerve palsy. ( 25267832 )
2014
45
Sixth nerve palsy associated with obstruction in Dorello's canal, accompanied by nodular type muscular sarcoidosis. ( 24930400 )
2014
46
The role of neuroimaging in the evaluation process of children with isolated sixth nerve palsy. ( 23001023 )
2013
47
Vertical muscle transposition augmented with lateral fixation (Foster) suture for Duane syndrome and sixth nerve palsy. ( 23907625 )
2013
48
Prognosis for sixth nerve palsy arising from paranasal sinus disease. ( 24119609 )
2013
49
Malignant transformation of a Schneiderian papilloma presenting with isolated sixth nerve palsy. ( 23244315 )
2013
50
Isolated sixth nerve palsy from hemorrhage of a pontine cavernous malformation. ( 22743823 )
2012

Variations for Abducens Nerve Disease

Expression for Abducens Nerve Disease

Search GEO for disease gene expression data for Abducens Nerve Disease.

Pathways for Abducens Nerve Disease

GO Terms for Abducens Nerve Disease

Molecular functions related to Abducens Nerve Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.1 ASPA B2M SAMHD1 SERPINC1 SYP TCF4

Sources for Abducens Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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