MCID: ABD002
MIFTS: 29

Abducens Nerve Disease

Categories: Rare diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Abducens Nerve Disease

MalaCards integrated aliases for Abducens Nerve Disease:

Name: Abducens Nerve Disease 12
Sixth Nerve Palsy 12 76 53
Abducens Nerve Diseases 44 73
Cranial Nerve Vi Palsy 53 29
Lateral Rectus Muscle Innervation Disorder 12
Lateral Rectus Muscle Denervation Paresis 12
Sixth or Abducens Nerve Palsy 12
Sixth Cranial Nerve Disorder 12
Disorder of Abducent Nerve 12
Cranial Mononeuropathy Vi 53
Sixth Cranial Nerve Palsy 53
Abducens Nerve Disorder 12
Abducens Nerve Weakness 12
Vith Nerve Paralysis 12
Abducens Nerve Palsy 53
Vith Nerve Disorder 12
6th Nerve Palsy 53
Vi Nerve Palsy 53

Classifications:



External Ids:

Disease Ontology 12 DOID:10865
ICD10 33 H49.2
ICD9CM 35 378.54
MeSH 44 D020434
UMLS 73 C0271355

Summaries for Abducens Nerve Disease

NIH Rare Diseases : 53 Sixth nerve palsy is a nerve disorder that occurs when the sixth cranial nerve is damaged. The disorder prevents some of the muscles that control eye movement from working properly. Affected people cannot turn the eye outwards toward the ear. Other signs and symptoms may include double vision, headaches, and pain around the eye. Sixth nerve palsy may be caused by many things, including stroke, brain aneurysm, diabetic neuropathy, trauma, infections, inflammation, tumors, migraine headaches or intracranial pressure. Eye patches, glasses, corticosteroids, and/or botulinum toxin may be used to ease symptoms. Some people may not need any treatment, while others may need surgery.

MalaCards based summary : Abducens Nerve Disease, also known as sixth nerve palsy, is related to congenital abducens nerve palsy and horner's syndrome. Affiliated tissues include eye and brain.

Wikipedia : 76 Sixth nerve palsy, or abducens nerve palsy, is a disorder associated with dysfunction of cranial nerve... more...

Related Diseases for Abducens Nerve Disease

Diseases related to Abducens Nerve Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 congenital abducens nerve palsy 11.3
2 horner's syndrome 10.2
3 herpes zoster 10.1
4 herpes zoster ophthalmicus 10.1
5 chronic inflammatory demyelinating polyneuropathy 10.0
6 polyneuropathy 10.0
7 papilledema 10.0
8 demyelinating polyneuropathy 10.0
9 esotropia 10.0
10 aneurysm 10.0
11 headache 10.0
12 abducens palsy 9.8
13 myositis 9.8
14 otitis media 9.8
15 ovarian cancer 9.8
16 strabismus 9.8
17 chondrosarcoma 9.8
18 factor xii deficiency 9.8
19 lymphoma, hodgkin, classic 9.8
20 intracranial hypertension, idiopathic 9.8
21 myeloma, multiple 9.8
22 pendred syndrome 9.8
23 lymphoma, non-hodgkin, familial 9.8
24 leukemia, acute lymphoblastic 9.8
25 multiple enchondromatosis, maffucci type 9.8
26 leukemia 9.8
27 sinusitis 9.8
28 lymphoma 9.8
29 thrombosis 9.8
30 xerophthalmia 9.8
31 lymphoblastic leukemia 9.8
32 meningoencephalitis 9.8
33 sphenoid sinusitis 9.8
34 paralytic squint 9.8
35 suppurative otitis media 9.8
36 nephrotic syndrome 9.8
37 duane retraction syndrome 9.8
38 paranasal sinus disease 9.8
39 papilloma 9.8
40 cerebritis 9.8
41 sagittal sinus thrombosis 9.8
42 skull base meningioma 9.8
43 intracranial hypotension 9.8
44 central pontine myelinolysis 9.8
45 intracranial chondrosarcoma 9.8
46 herpes simplex 9.8
47 cluster headache 9.8
48 duane syndrome type 1 9.8
49 ependymoma 9.8
50 ocular neuromyotonia 9.8

Comorbidity relations with Abducens Nerve Disease via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Abducens Nerve Disease:



Diseases related to Abducens Nerve Disease

Symptoms & Phenotypes for Abducens Nerve Disease

Drugs & Therapeutics for Abducens Nerve Disease

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Strabismus Measurements Using Automated 3D Video Oculography Completed NCT02228070 Not Applicable
2 Effects of Ocular Electroacupuncture on Abducens Nerve Palsy Recruiting NCT03099460 Not Applicable
3 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
4 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Abducens Nerve Disease

Cochrane evidence based reviews: abducens nerve diseases

Genetic Tests for Abducens Nerve Disease

Genetic tests related to Abducens Nerve Disease:

# Genetic test Affiliating Genes
1 Cranial Nerve Vi Palsy 29

Anatomical Context for Abducens Nerve Disease

MalaCards organs/tissues related to Abducens Nerve Disease:

41
Eye, Brain

Publications for Abducens Nerve Disease

Articles related to Abducens Nerve Disease:

(show all 44)
# Title Authors Year
1
Augmented superior rectus transposition procedure in Duane retraction syndrome compared with sixth nerve palsy. ( 29299740 )
2018
2
Augmented vertical recti transposition with intraoperative botulinum toxin for complete and chronic sixth nerve palsy. ( 27813529 )
2017
3
Double Augmented Vertical Rectus Transposition for Large-Angle Esotropia Due to Sixth Nerve Palsy. ( 27537250 )
2016
4
Central pontine myelinolysis presenting as isolated sixth nerve palsy in third trimester of pregnancy. ( 25745319 )
2015
5
Varicella vasculopathy and chronic suppurative otitis media: Differential diagnosis for isolated sixth nerve palsy. ( 26655013 )
2015
6
Maffucci syndrome and intracranial chondrosarcomas: a case report featuring spontaneous resolution of sixth nerve palsy. ( 24978479 )
2015
7
Recurrent Isolated Sixth Nerve Palsy in Relapsing-Remitting Chronic Inflammatory Demyelinating Polyneuropathy. ( 26301375 )
2015
8
Ocular Neuromyotonia Noted after Recent Botulinum Toxin Injection for Sixth Nerve Palsy Following Resection of a Posterior Fossa Skull Base Meningioma. ( 27928330 )
2015
9
Fourth and sixth nerve palsies due to Herpes Simplex 1 infection. ( 25313788 )
2015
10
The diagnostic yield of neuroimaging in sixth nerve palsy--Sankara Nethralaya Abducens Palsy Study (SNAPS): Report 1. ( 25449936 )
2014
11
Benign recurrent sixth nerve palsy in an infant. ( 25608226 )
2014
12
Malignant transformation of a Schneiderian papilloma presenting with isolated sixth nerve palsy. ( 23244315 )
2013
13
The role of neuroimaging in the evaluation process of children with isolated sixth nerve palsy. ( 23001023 )
2013
14
Prognosis for sixth nerve palsy arising from paranasal sinus disease. ( 24119609 )
2013
15
Bevacizumab-induced transient sixth nerve palsy in ovarian cancer: A case report. ( 24188139 )
2013
16
Isolated sixth nerve palsy from hemorrhage of a pontine cavernous malformation. ( 22743823 )
2012
17
Are most sixth nerve palsies really paralytic? ( 20672767 )
2011
18
Cluster headache associated with a sixth nerve palsy: a case report. ( 20670995 )
2011
19
Vertical rectus muscle transposition for correcting abduction deficiency in Duane's syndrome type 1 and sixth nerve palsy. ( 20349902 )
2010
20
Recurrent orbital myositis mimicking sixth nerve palsy: diagnosis with MR imaging. ( 19778999 )
2010
21
Paralytic strabismus: third, fourth, and sixth nerve palsy. ( 20638001 )
2010
22
Multiple myeloma manifesting as a fluctuating sixth nerve palsy. ( 19794956 )
2009
23
Superior sagittal sinus thrombosis and bilateral sixth-nerve palsy in a child with nephrotic syndrome. ( 17333003 )
2007
24
Herpes zoster ophthalmicus and sixth nerve palsy in a pediatric patient. ( 17361269 )
2007
25
Isolated unilateral sixth nerve palsy as a presenting symptom of cerebral aneurysms. Report of two cases. ( 24299595 )
2007
26
Isolated sixth nerve palsy secondary to spontaneous intracranial hypotension. ( 17038044 )
2006
27
Horner's syndrome and sixth nerve palsy due to herpes zoster ophthalmicus arteritis. ( 15232597 )
2005
28
Recurrent headache and sixth nerve palsy associated with lumbar ependymoma. ( 15726275 )
2005
29
Bilateral sixth nerve palsy in West Nile meningoencephalitis. ( 15206452 )
2004
30
Unilateral corneal anaesthesia and ulceration following squint surgery in a child with Pendred syndrome and bilateral sixth nerve palsy. ( 12928303 )
2003
31
Factor XII deficiency and recurrent sixth nerve palsy. ( 12598465 )
2003
32
Horner's syndrome and sixth nerve palsy. ( 10697242 )
2000
33
Acute sixth nerve palsy in vitamin A treatment of xerophthalmia. ( 10979654 )
2000
34
Pseudotumor cerebri sine papilledema with unilateral sixth nerve palsy. ( 9532543 )
1998
35
Cyclic esotropia after a traumatic sixth nerve palsy in a child. ( 10532729 )
1998
36
Non-Hodgkin lymphoma with panhypopituitarism, hyperprolactinaemia and sixth nerve palsy. ( 9204025 )
1997
37
Sixth nerve palsy from a CNS lesion in chronic inflammatory demyelinating polyneuropathy. ( 8648345 )
1996
38
MR features of pachymeningitis presenting with sixth-nerve palsy secondary to sphenoid sinusitis. ( 7611085 )
1995
39
Spontaneous remission of papilledema and sixth nerve palsy in acute lymphoblastic leukemia. ( 7951935 )
1994
40
Central bilateral sixth nerve palsy associated with a unilateral preganglionic Horner's syndrome. ( 2971682 )
1988
41
Cavernous sinus infection manifested by Horner's syndrome and ipsilateral sixth nerve palsy. ( 2963028 )
1987
42
Sixth nerve palsy and unilateral Horner's syndrome. ( 3763136 )
1986
43
An unrecognized neurological syndrome: sixth-nerve palsy and Horner's syndrome due to traumatic intracavernous carotid aneurysm. ( 7280987 )
1981
44
Herpes zoster ophthalmicus with sixth nerve palsy. ( 5302943 )
1968

Variations for Abducens Nerve Disease

Expression for Abducens Nerve Disease

Search GEO for disease gene expression data for Abducens Nerve Disease.

Pathways for Abducens Nerve Disease

GO Terms for Abducens Nerve Disease

Sources for Abducens Nerve Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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