MCID: ABN002
MIFTS: 17

Abnormality of Glucagon Secretion

Categories: Endocrine diseases

Aliases & Classifications for Abnormality of Glucagon Secretion

MalaCards integrated aliases for Abnormality of Glucagon Secretion:

Name: Abnormality of Glucagon Secretion 12 15
Abnormality of Secretion of Glucagon 71
Glucagon Secretion Abnormality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14427
ICD9CM 34 251.4
SNOMED-CT 67 11178005
UMLS 71 C0154191

Summaries for Abnormality of Glucagon Secretion

MalaCards based summary : Abnormality of Glucagon Secretion, also known as abnormality of secretion of glucagon, is related to duodenal gastrinoma and pancreatic cholera. An important gene associated with Abnormality of Glucagon Secretion is RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway.

Related Diseases for Abnormality of Glucagon Secretion

Diseases related to Abnormality of Glucagon Secretion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)
# Related Disease Score Top Affiliating Genes
1 duodenal gastrinoma 10.1 SST GCG
2 pancreatic cholera 10.1 SST GCG
3 cervical large cell neuroendocrine carcinoma 10.1 SST GCG
4 neuroendocrine carcinoma 10.1 SST GCG
5 pancreatic gastrinoma 10.1 SST GCG
6 bile acid malabsorption, primary 10.1 SST GCG
7 amyloidosis, hereditary, transthyretin-related 10.1 SERPINA7 IAPP
8 alzheimer disease 6 10.0 IAPP GCG
9 pancreatic endocrine carcinoma 10.0 SST GCG
10 somatostatinoma 10.0 SST GCG
11 corticosteroid-binding globulin deficiency 10.0 SERPINA7 NR3C1
12 prediabetes syndrome 10.0 IAPP GCG
13 carbohydrate metabolic disorder 10.0 SST GCG
14 pituitary-dependent cushing's disease 9.9 SST NR3C1
15 nelson syndrome 9.9 SST NR3C1
16 acth-secreting pituitary adenoma 9.9 SST NR3C1
17 pituitary gland disease 9.9 SST GCG
18 adrenal cortex disease 9.9 SST NR3C1
19 hyperinsulinemic hypoglycemia 9.9 SST GCG
20 adrenal gland disease 9.9 SST NR3C1
21 apnea, obstructive sleep 9.8 GHRL GCG
22 growth hormone secreting pituitary adenoma 9.8 SST GHRL
23 pancreatic cystadenoma 9.7 SST IAPP GCG
24 islet cell tumor 9.7 SST IAPP GCG
25 gastroparesis 9.7 SST GHRL
26 gastrointestinal system benign neoplasm 9.7 SST IAPP GCG
27 abdominal obesity-metabolic syndrome 1 9.7 GHRL GCG
28 insulinoma 9.7 SST IAPP GCG
29 intestinal obstruction 9.7 SST GHRL
30 endocrine organ benign neoplasm 9.7 SST GCG
31 ileus 9.7 SST GHRL
32 endocrine gland cancer 9.6 SST IAPP GCG
33 maturity-onset diabetes of the young 9.6 SST IAPP GCG
34 peptic ulcer disease 9.6 SST GHRL
35 goiter 9.6 SST SERPINA7
36 atrophic gastritis 9.6 SST GHRL
37 diabetes mellitus, insulin-dependent 9.5 SST IAPP GCG
38 leptin deficiency or dysfunction 9.5 GHRL GCG
39 irritable bowel syndrome 9.5 SST GHRL
40 hyperthyroidism 9.5 SST SERPINA7 GHRL
41 postgastrectomy syndrome 9.5 SST GHRL GCG
42 dumping syndrome 9.5 SST GHRL GCG
43 functional gastric disease 9.5 SST GHRL GCG
44 endocrine pancreas disease 9.5 SST GHRL GCG
45 short bowel syndrome 9.5 SST GHRL GCG
46 neuroendocrine tumor 9.5 SST GHRL GCG
47 multiple endocrine neoplasia, type i 9.5 SST GHRL GCG
48 glucose intolerance 9.4 IAPP GHRL GCG
49 hypothyroidism 9.4 SST SERPINA7 GHRL
50 conn's syndrome 9.3 SST NR3C1 GHRL

Graphical network of the top 20 diseases related to Abnormality of Glucagon Secretion:



Diseases related to Abnormality of Glucagon Secretion

Symptoms & Phenotypes for Abnormality of Glucagon Secretion

Drugs & Therapeutics for Abnormality of Glucagon Secretion

Search Clinical Trials , NIH Clinical Center for Abnormality of Glucagon Secretion

Genetic Tests for Abnormality of Glucagon Secretion

Anatomical Context for Abnormality of Glucagon Secretion

Publications for Abnormality of Glucagon Secretion

Articles related to Abnormality of Glucagon Secretion:

# Title Authors PMID Year
1
Glucagon release: paradoxical stimulation by glucose during calcium deprivation. 61
1098149 1975

Variations for Abnormality of Glucagon Secretion

Expression for Abnormality of Glucagon Secretion

Search GEO for disease gene expression data for Abnormality of Glucagon Secretion.

Pathways for Abnormality of Glucagon Secretion

GO Terms for Abnormality of Glucagon Secretion

Cellular components related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 SST SERPINA7 IAPP GHRL GCG
2 extracellular space GO:0005615 9.02 SST SERPINA7 IAPP GHRL GCG

Biological processes related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.26 SST IAPP GHRL GCG
2 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 8.62 GHRL GCG

Molecular functions related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 SST IAPP GHRL GCG

Sources for Abnormality of Glucagon Secretion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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