Abnormality of Glucagon Secretion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Abnormality of Glucagon Secretion

MalaCards integrated aliases for Abnormality of Glucagon Secretion:

Name: Abnormality of Glucagon Secretion ¹² ¹⁵

Abnormality of Secretion of Glucagon ⁷¹

Glucagon Secretion Abnormality ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14427

ICD9CM ³⁴ 251.4

SNOMED-CT ⁶⁷ 11178005

UMLS ⁷¹ C0154191

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Summaries for Abnormality of Glucagon Secretion

MalaCards based summary : Abnormality of Glucagon Secretion, also known as abnormality of secretion of glucagon, is related to duodenal gastrinoma and endocrine pancreas disease. An important gene associated with Abnormality of Glucagon Secretion is RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway.

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Related Diseases for Abnormality of Glucagon Secretion

Diseases related to Abnormality of Glucagon Secretion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)

#	Related Disease	Score	Top Affiliating Genes
1	duodenal gastrinoma	10.1	SST GCG
2	endocrine pancreas disease	10.1	SST GCG
3	pancreatic gastrinoma	10.1	SST GCG
4	pancreatic cholera	10.1	SST GCG
5	angular cheilitis	10.1	SST GCG
6	amyloidosis, hereditary, transthyretin-related	10.1	SERPINA7 IAPP
7	bile acid malabsorption, primary	10.1	SST GCG
8	meckel diverticulum	10.1	SST GCG
9	pancreatic endocrine carcinoma	10.0	SST GCG
10	volvulus of midgut	10.0	SST GCG
11	somatostatinoma	10.0	SST GCG
12	corticosteroid-binding globulin deficiency	10.0	SERPINA7 NR3C1
13	ectopic cushing syndrome	10.0	SST NR3C1
14	thyroid gland disease	10.0	SST SERPINA7
15	pituitary gland disease	10.0	SST GCG
16	pituitary-dependent cushing's disease	10.0	SST NR3C1
17	nelson syndrome	10.0	SST NR3C1
18	gastrointestinal system benign neoplasm	10.0	SST GCG
19	acth-secreting pituitary adenoma	9.9	SST NR3C1
20	neuroendocrine carcinoma	9.9	SST GCG
21	adrenal gland disease	9.9	SST NR3C1
22	goiter	9.9	SST SERPINA7
23	hyperinsulinemic hypoglycemia	9.9	SST GCG
24	apnea, obstructive sleep	9.9	GHRL GCG
25	growth hormone secreting pituitary adenoma	9.8	SST GHRL
26	pancreatic cystadenoma	9.8	SST IAPP GCG
27	ileus	9.8	SST GHRL
28	islet cell tumor	9.8	SST IAPP GCG
29	gastroparesis	9.8	SST GHRL
30	insulinoma	9.8	SST IAPP GCG
31	peptic ulcer disease	9.8	SST GHRL
32	irritable bowel syndrome	9.8	SST GHRL
33	eating disorder	9.8	GHRL GCG
34	atrophic gastritis	9.8	SST GHRL
35	endocrine gland cancer	9.8	SST IAPP GCG
36	maturity-onset diabetes of the young	9.7	SST IAPP GCG
37	type 1 diabetes mellitus	9.7	SST IAPP GCG
38	abdominal obesity-metabolic syndrome 1	9.7	GHRL GCG
39	sleep disorder	9.7	GHRL GCG
40	teratoma	9.7	SST GCG
41	hyperthyroidism	9.7	SST SERPINA7 GHRL
42	postgastrectomy syndrome	9.6	SST GHRL GCG
43	functional gastric disease	9.6	SST GHRL GCG
44	dumping syndrome	9.6	SST GHRL GCG
45	short bowel syndrome	9.6	SST GHRL GCG
46	prediabetes syndrome	9.6	IAPP GHRL GCG
47	multiple endocrine neoplasia, type i	9.6	SST GHRL GCG
48	glucose intolerance	9.6	SST GHRL GCG
49	hyperinsulinism	9.6	SST GHRL GCG
50	acquired metabolic disease	9.6	IAPP GHRL GCG

Graphical network of the top 20 diseases related to Abnormality of Glucagon Secretion:

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Symptoms & Phenotypes for Abnormality of Glucagon Secretion

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Drugs & Therapeutics for Abnormality of Glucagon Secretion

Search Clinical Trials , NIH Clinical Center for Abnormality of Glucagon Secretion

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Genetic Tests for Abnormality of Glucagon Secretion

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Anatomical Context for Abnormality of Glucagon Secretion

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Publications for Abnormality of Glucagon Secretion

Articles related to Abnormality of Glucagon Secretion:

#	Title	Authors	PMID	Year
1	Glucagon release: paradoxical stimulation by glucose during calcium deprivation. ⁶¹	Leclercq-Meyer V...Malaisse W	1098149	1975

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Genes for Abnormality of Glucagon Secretion

Genes related to Abnormality of Glucagon Secretion (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RGL1	Ral Guanine Nucleotide Dissociation Stimulator Like 1	Protein Coding	6.14	DISEASES inferred ¹⁵
2	SERPINA7	Serpin Family A Member 7	Protein Coding	5.01	DISEASES inferred ¹⁵
3	GCG	Glucagon	Protein Coding	4.93	DISEASES inferred ¹⁵
4	IAPP	Islet Amyloid Polypeptide	Protein Coding	4.22	DISEASES inferred ¹⁵
5	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	3.9	DISEASES inferred ¹⁵
6	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	3.83	DISEASES inferred ¹⁵
7	SST	Somatostatin	Protein Coding	3.51	DISEASES inferred ¹⁵

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Variations for Abnormality of Glucagon Secretion

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Expression for Abnormality of Glucagon Secretion

Search GEO for disease gene expression data for Abnormality of Glucagon Secretion.

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Pathways for Abnormality of Glucagon Secretion

Pathways related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide ligand-binding receptors ⁶⁵ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁵ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁵ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁵ G alpha (i) signalling events ⁶⁵ GPCR ligand binding ⁶⁵ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁶ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁵ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁵ Vasopressin-like receptors ⁶⁵	12.64	SST NR3C1 IAPP GHRL GCG
2	cAMP signaling pathway ³⁶	11.13	SST GHRL GCG

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GO Terms for Abnormality of Glucagon Secretion

Cellular components related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.35	SST SERPINA7 IAPP GHRL GCG
2	extracellular space	GO:0005615	9.02	SST SERPINA7 IAPP GHRL GCG

Biological processes related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor signaling pathway	GO:0007186	9.26	SST IAPP GHRL GCG
2	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0035774	8.62	GHRL GCG

Molecular functions related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	8.92	SST IAPP GHRL GCG

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Sources for Abnormality of Glucagon Secretion

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