Abnormality of Glucagon Secretion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Abnormality of Glucagon Secretion

MalaCards integrated aliases for Abnormality of Glucagon Secretion:

Name: Abnormality of Glucagon Secretion ¹² ¹⁵

Abnormality of Secretion of Glucagon ⁷¹

Glucagon Secretion Abnormality ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14427

ICD9CM ³⁴ 251.4

SNOMED-CT ⁶⁷ 11178005

UMLS ⁷¹ C0154191

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Summaries for Abnormality of Glucagon Secretion

MalaCards based summary : Abnormality of Glucagon Secretion, also known as abnormality of secretion of glucagon, is related to petrositis and duodenal gastrinoma. An important gene associated with Abnormality of Glucagon Secretion is RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway.

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Related Diseases for Abnormality of Glucagon Secretion

Diseases related to Abnormality of Glucagon Secretion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)

#	Related Disease	Score	Top Affiliating Genes
1	petrositis	10.1	SST GCG
2	duodenal gastrinoma	10.1	SST GCG
3	pancreatic cholera	10.1	SST GCG
4	pancreatic gastrinoma	10.1	SST GCG
5	endocrine pancreas disease	10.1	SST GCG
6	angular cheilitis	10.1	SST GCG
7	bile acid malabsorption, primary	10.1	SST GCG
8	meckel diverticulum	10.1	SST GCG
9	pancreatic endocrine carcinoma	10.1	SST GCG
10	somatostatinoma	10.1	SST GCG
11	prediabetes syndrome	10.0	IAPP GCG
12	amyloidosis, hereditary, transthyretin-related	10.0	SERPINA7 IAPP
13	corticosteroid-binding globulin deficiency	10.0	SERPINA7 NR3C1
14	pituitary-dependent cushing's disease	9.9	SST NR3C1
15	hyperinsulinemic hypoglycemia	9.9	SST GCG
16	nelson syndrome	9.9	SST NR3C1
17	pituitary gland disease	9.9	SST GCG
18	acth-secreting pituitary adenoma	9.9	SST NR3C1
19	adrenal gland disease	9.9	SST NR3C1
20	thyroid gland disease	9.8	SST SERPINA7
21	apnea, obstructive sleep	9.8	GHRL GCG
22	personality disorder	9.8	SST NR3C1
23	gastrointestinal system benign neoplasm	9.8	SST GCG
24	growth hormone secreting pituitary adenoma	9.7	SST GHRL
25	abdominal obesity-metabolic syndrome 1	9.7	GHRL GCG
26	pancreatic cystadenoma	9.7	SST IAPP GCG
27	islet cell tumor	9.7	SST IAPP GCG
28	insulinoma	9.7	SST IAPP GCG
29	gastroparesis	9.7	SST GHRL
30	neuroendocrine carcinoma	9.7	SST GCG
31	intestinal obstruction	9.7	SST GHRL
32	ileus	9.7	SST GHRL
33	endocrine gland cancer	9.7	SST IAPP GCG
34	maturity-onset diabetes of the young	9.6	SST IAPP GCG
35	peptic ulcer disease	9.6	SST GHRL
36	diabetes mellitus, type i	9.6	SST IAPP GCG
37	atrophic gastritis	9.6	SST GHRL
38	goiter	9.5	SST SERPINA7
39	irritable bowel syndrome	9.5	SST GHRL
40	postgastrectomy syndrome	9.5	SST GHRL GCG
41	functional gastric disease	9.5	SST GHRL GCG
42	dumping syndrome	9.5	SST GHRL GCG
43	short bowel syndrome	9.5	SST GHRL GCG
44	stomach disease	9.5	SST GHRL GCG
45	multiple endocrine neoplasia, type i	9.5	SST GHRL GCG
46	neuroendocrine tumor	9.5	SST GHRL GCG
47	leptin deficiency or dysfunction	9.5	IAPP GHRL GCG
48	glucose intolerance	9.5	IAPP GHRL GCG
49	hyperthyroidism	9.5	SST SERPINA7 GHRL
50	acquired metabolic disease	9.5	IAPP GHRL GCG

Graphical network of the top 20 diseases related to Abnormality of Glucagon Secretion:

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Symptoms & Phenotypes for Abnormality of Glucagon Secretion

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Drugs & Therapeutics for Abnormality of Glucagon Secretion

Search Clinical Trials , NIH Clinical Center for Abnormality of Glucagon Secretion

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Genetic Tests for Abnormality of Glucagon Secretion

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Anatomical Context for Abnormality of Glucagon Secretion

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Publications for Abnormality of Glucagon Secretion

Articles related to Abnormality of Glucagon Secretion:

#	Title	Authors	PMID	Year
1	Glucagon release: paradoxical stimulation by glucose during calcium deprivation. ⁶¹	Leclercq-Meyer V...Malaisse W	1098149	1975

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Genes for Abnormality of Glucagon Secretion

Genes related to Abnormality of Glucagon Secretion (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RGL1	Ral Guanine Nucleotide Dissociation Stimulator Like 1	Protein Coding	5.93	DISEASES inferred ¹⁵
2	NBPF12	NBPF Member 12	Protein Coding	5.61	DISEASES inferred ¹⁵
3	GCG	Glucagon	Protein Coding	4.96	DISEASES inferred ¹⁵
4	SERPINA7	Serpin Family A Member 7	Protein Coding	4.96	DISEASES inferred ¹⁵
5	IAPP	Islet Amyloid Polypeptide	Protein Coding	4.25	DISEASES inferred ¹⁵
6	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	3.9	DISEASES inferred ¹⁵
7	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	3.88	DISEASES inferred ¹⁵
8	SST	Somatostatin	Protein Coding	3.56	DISEASES inferred ¹⁵

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Variations for Abnormality of Glucagon Secretion

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Expression for Abnormality of Glucagon Secretion

Search GEO for disease gene expression data for Abnormality of Glucagon Secretion.

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Pathways for Abnormality of Glucagon Secretion

Pathways related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide ligand-binding receptors ⁶⁵ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁵ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁵ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁵ G alpha (i) signalling events ⁶⁵ GPCR ligand binding ⁶⁵ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁶ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁵ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁵ Vasopressin-like receptors ⁶⁵	12.64	SST NR3C1 IAPP GHRL GCG
2	cAMP signaling pathway ³⁶	11.13	SST GHRL GCG

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GO Terms for Abnormality of Glucagon Secretion

Cellular components related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.02	SST SERPINA7 IAPP GHRL GCG

Biological processes related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor signaling pathway	GO:0007186	9.26	SST IAPP GHRL GCG
2	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0035774	8.62	GHRL GCG

Molecular functions related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	8.92	SST IAPP GHRL GCG

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