Abnormality of Glucagon Secretion disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Abnormality of Glucagon Secretion

MalaCards integrated aliases for Abnormality of Glucagon Secretion:

Name: Abnormality of Glucagon Secretion ¹² ¹⁵

Abnormality of Secretion of Glucagon ⁷¹

Glucagon Secretion Abnormality ¹²

Classifications:

MalaCards categories:
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:14427

ICD9CM ³⁴ 251.4

SNOMED-CT ⁶⁷ 11178005

UMLS ⁷¹ C0154191

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Summaries for Abnormality of Glucagon Secretion

MalaCards based summary : Abnormality of Glucagon Secretion, also known as abnormality of secretion of glucagon, is related to duodenal gastrinoma and pancreatic cholera. An important gene associated with Abnormality of Glucagon Secretion is RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. Affiliated tissues include pituitary, cortex and pancreas.

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Related Diseases for Abnormality of Glucagon Secretion

Diseases related to Abnormality of Glucagon Secretion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 59)

#	Related Disease	Score	Top Affiliating Genes
1	duodenal gastrinoma	10.1	SST GCG
2	pancreatic cholera	10.1	SST GCG
3	cervical large cell neuroendocrine carcinoma	10.1	SST GCG
4	neuroendocrine carcinoma	10.1	SST GCG
5	pancreatic gastrinoma	10.1	SST GCG
6	bile acid malabsorption, primary	10.1	SST GCG
7	amyloidosis, hereditary, transthyretin-related	10.1	SERPINA7 IAPP
8	alzheimer disease 6	10.0	IAPP GCG
9	pancreatic endocrine carcinoma	10.0	SST GCG
10	somatostatinoma	10.0	SST GCG
11	corticosteroid-binding globulin deficiency	10.0	SERPINA7 NR3C1
12	prediabetes syndrome	10.0	IAPP GCG
13	carbohydrate metabolic disorder	10.0	SST GCG
14	pituitary-dependent cushing's disease	9.9	SST NR3C1
15	nelson syndrome	9.9	SST NR3C1
16	acth-secreting pituitary adenoma	9.9	SST NR3C1
17	pituitary gland disease	9.9	SST GCG
18	adrenal cortex disease	9.9	SST NR3C1
19	hyperinsulinemic hypoglycemia	9.9	SST GCG
20	adrenal gland disease	9.9	SST NR3C1
21	apnea, obstructive sleep	9.8	GHRL GCG
22	growth hormone secreting pituitary adenoma	9.8	SST GHRL
23	pancreatic cystadenoma	9.7	SST IAPP GCG
24	islet cell tumor	9.7	SST IAPP GCG
25	gastroparesis	9.7	SST GHRL
26	gastrointestinal system benign neoplasm	9.7	SST IAPP GCG
27	abdominal obesity-metabolic syndrome 1	9.7	GHRL GCG
28	insulinoma	9.7	SST IAPP GCG
29	intestinal obstruction	9.7	SST GHRL
30	endocrine organ benign neoplasm	9.7	SST GCG
31	ileus	9.7	SST GHRL
32	endocrine gland cancer	9.6	SST IAPP GCG
33	maturity-onset diabetes of the young	9.6	SST IAPP GCG
34	peptic ulcer disease	9.6	SST GHRL
35	goiter	9.6	SST SERPINA7
36	atrophic gastritis	9.6	SST GHRL
37	diabetes mellitus, insulin-dependent	9.5	SST IAPP GCG
38	leptin deficiency or dysfunction	9.5	GHRL GCG
39	irritable bowel syndrome	9.5	SST GHRL
40	hyperthyroidism	9.5	SST SERPINA7 GHRL
41	postgastrectomy syndrome	9.5	SST GHRL GCG
42	dumping syndrome	9.5	SST GHRL GCG
43	functional gastric disease	9.5	SST GHRL GCG
44	endocrine pancreas disease	9.5	SST GHRL GCG
45	short bowel syndrome	9.5	SST GHRL GCG
46	neuroendocrine tumor	9.5	SST GHRL GCG
47	multiple endocrine neoplasia, type i	9.5	SST GHRL GCG
48	glucose intolerance	9.4	IAPP GHRL GCG
49	hypothyroidism	9.4	SST SERPINA7 GHRL
50	conn's syndrome	9.3	SST NR3C1 GHRL

Graphical network of the top 20 diseases related to Abnormality of Glucagon Secretion:

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Symptoms & Phenotypes for Abnormality of Glucagon Secretion

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Drugs & Therapeutics for Abnormality of Glucagon Secretion

Search Clinical Trials , NIH Clinical Center for Abnormality of Glucagon Secretion

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Genetic Tests for Abnormality of Glucagon Secretion

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Anatomical Context for Abnormality of Glucagon Secretion

MalaCards organs/tissues related to Abnormality of Glucagon Secretion:

⁴⁰

Pituitary, Cortex, Pancreas, Adrenal Gland, Adrenal Cortex

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Publications for Abnormality of Glucagon Secretion

Articles related to Abnormality of Glucagon Secretion:

#	Title	Authors	PMID	Year
1	Glucagon release: paradoxical stimulation by glucose during calcium deprivation. ⁶¹	Leclercq-Meyer V...Malaisse W	1098149	1975

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Genes for Abnormality of Glucagon Secretion

Genes related to Abnormality of Glucagon Secretion (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RGL1	Ral Guanine Nucleotide Dissociation Stimulator Like 1	Protein Coding	5.98	DISEASES inferred ¹⁵
2	NBPF12	NBPF Member 12	Protein Coding	5.63	DISEASES inferred ¹⁵
3	SERPINA7	Serpin Family A Member 7	Protein Coding	5.03	DISEASES inferred ¹⁵
4	GCG	Glucagon	Protein Coding	4.96	DISEASES inferred ¹⁵
5	IAPP	Islet Amyloid Polypeptide	Protein Coding	4.25	DISEASES inferred ¹⁵
6	NR3C1	Nuclear Receptor Subfamily 3 Group C Member 1	Protein Coding	3.91	DISEASES inferred ¹⁵
7	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	3.88	DISEASES inferred ¹⁵
8	SST	Somatostatin	Protein Coding	3.54	DISEASES inferred ¹⁵

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Variations for Abnormality of Glucagon Secretion

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Expression for Abnormality of Glucagon Secretion

Search GEO for disease gene expression data for Abnormality of Glucagon Secretion.

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Pathways for Abnormality of Glucagon Secretion

Pathways related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide ligand-binding receptors ⁶⁵ Show member pathways Class A/1 (Rhodopsin-like receptors) ⁶⁵ Defective AVP causes neurohypophyseal diabetes insipidus (NDI) ⁶⁵ Formyl peptide receptors bind formyl peptides and many other ligands ⁶⁵ G alpha (i) signalling events ⁶⁵ GPCR ligand binding ⁶⁵ GPCRs, Class A Rhodopsin-like ¹ Neuroactive ligand-receptor interaction ³⁶ Orexin and neuropeptides FF and QRFP bind to their respective receptors ⁶⁵ Peptide GPCRs ¹ Tachykinin receptors bind tachykinins ⁶⁵ Vasopressin-like receptors ⁶⁵	12.64	SST NR3C1 IAPP GHRL GCG
2	cAMP signaling pathway ³⁶	11.13	SST GHRL GCG

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GO Terms for Abnormality of Glucagon Secretion

Cellular components related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.35	SST SERPINA7 IAPP GHRL GCG
2	extracellular space	GO:0005615	9.02	SST SERPINA7 IAPP GHRL GCG

Biological processes related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	G protein-coupled receptor signaling pathway	GO:0007186	9.26	SST IAPP GHRL GCG
2	positive regulation of insulin secretion involved in cellular response to glucose stimulus	GO:0035774	8.62	GHRL GCG

Molecular functions related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	hormone activity	GO:0005179	8.92	SST IAPP GHRL GCG

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Sources for Abnormality of Glucagon Secretion

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