MCID: ABN002
MIFTS: 16

Abnormality of Glucagon Secretion

Categories: Endocrine diseases

Aliases & Classifications for Abnormality of Glucagon Secretion

MalaCards integrated aliases for Abnormality of Glucagon Secretion:

Name: Abnormality of Glucagon Secretion 12 15
Abnormality of Secretion of Glucagon 71
Glucagon Secretion Abnormality 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14427
ICD9CM 34 251.4
SNOMED-CT 67 11178005
UMLS 71 C0154191

Summaries for Abnormality of Glucagon Secretion

MalaCards based summary : Abnormality of Glucagon Secretion, also known as abnormality of secretion of glucagon, is related to duodenal gastrinoma and endocrine pancreas disease. An important gene associated with Abnormality of Glucagon Secretion is RGL1 (Ral Guanine Nucleotide Dissociation Stimulator Like 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway.

Related Diseases for Abnormality of Glucagon Secretion

Diseases related to Abnormality of Glucagon Secretion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 duodenal gastrinoma 10.1 SST GCG
2 endocrine pancreas disease 10.1 SST GCG
3 pancreatic gastrinoma 10.1 SST GCG
4 pancreatic cholera 10.1 SST GCG
5 angular cheilitis 10.1 SST GCG
6 amyloidosis, hereditary, transthyretin-related 10.1 SERPINA7 IAPP
7 bile acid malabsorption, primary 10.1 SST GCG
8 meckel diverticulum 10.1 SST GCG
9 pancreatic endocrine carcinoma 10.0 SST GCG
10 volvulus of midgut 10.0 SST GCG
11 somatostatinoma 10.0 SST GCG
12 corticosteroid-binding globulin deficiency 10.0 SERPINA7 NR3C1
13 ectopic cushing syndrome 10.0 SST NR3C1
14 thyroid gland disease 10.0 SST SERPINA7
15 pituitary gland disease 10.0 SST GCG
16 pituitary-dependent cushing's disease 10.0 SST NR3C1
17 nelson syndrome 10.0 SST NR3C1
18 gastrointestinal system benign neoplasm 10.0 SST GCG
19 acth-secreting pituitary adenoma 9.9 SST NR3C1
20 neuroendocrine carcinoma 9.9 SST GCG
21 adrenal gland disease 9.9 SST NR3C1
22 goiter 9.9 SST SERPINA7
23 hyperinsulinemic hypoglycemia 9.9 SST GCG
24 apnea, obstructive sleep 9.9 GHRL GCG
25 growth hormone secreting pituitary adenoma 9.8 SST GHRL
26 pancreatic cystadenoma 9.8 SST IAPP GCG
27 ileus 9.8 SST GHRL
28 islet cell tumor 9.8 SST IAPP GCG
29 gastroparesis 9.8 SST GHRL
30 insulinoma 9.8 SST IAPP GCG
31 peptic ulcer disease 9.8 SST GHRL
32 irritable bowel syndrome 9.8 SST GHRL
33 eating disorder 9.8 GHRL GCG
34 atrophic gastritis 9.8 SST GHRL
35 endocrine gland cancer 9.8 SST IAPP GCG
36 maturity-onset diabetes of the young 9.7 SST IAPP GCG
37 type 1 diabetes mellitus 9.7 SST IAPP GCG
38 abdominal obesity-metabolic syndrome 1 9.7 GHRL GCG
39 sleep disorder 9.7 GHRL GCG
40 teratoma 9.7 SST GCG
41 hyperthyroidism 9.7 SST SERPINA7 GHRL
42 postgastrectomy syndrome 9.6 SST GHRL GCG
43 functional gastric disease 9.6 SST GHRL GCG
44 dumping syndrome 9.6 SST GHRL GCG
45 short bowel syndrome 9.6 SST GHRL GCG
46 prediabetes syndrome 9.6 IAPP GHRL GCG
47 multiple endocrine neoplasia, type i 9.6 SST GHRL GCG
48 glucose intolerance 9.6 SST GHRL GCG
49 hyperinsulinism 9.6 SST GHRL GCG
50 acquired metabolic disease 9.6 IAPP GHRL GCG

Graphical network of the top 20 diseases related to Abnormality of Glucagon Secretion:



Diseases related to Abnormality of Glucagon Secretion

Symptoms & Phenotypes for Abnormality of Glucagon Secretion

Drugs & Therapeutics for Abnormality of Glucagon Secretion

Search Clinical Trials , NIH Clinical Center for Abnormality of Glucagon Secretion

Genetic Tests for Abnormality of Glucagon Secretion

Anatomical Context for Abnormality of Glucagon Secretion

Publications for Abnormality of Glucagon Secretion

Articles related to Abnormality of Glucagon Secretion:

# Title Authors PMID Year
1
Glucagon release: paradoxical stimulation by glucose during calcium deprivation. 61
1098149 1975

Variations for Abnormality of Glucagon Secretion

Expression for Abnormality of Glucagon Secretion

Search GEO for disease gene expression data for Abnormality of Glucagon Secretion.

Pathways for Abnormality of Glucagon Secretion

GO Terms for Abnormality of Glucagon Secretion

Cellular components related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 SST SERPINA7 IAPP GHRL GCG
2 extracellular space GO:0005615 9.02 SST SERPINA7 IAPP GHRL GCG

Biological processes related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.26 SST IAPP GHRL GCG
2 positive regulation of insulin secretion involved in cellular response to glucose stimulus GO:0035774 8.62 GHRL GCG

Molecular functions related to Abnormality of Glucagon Secretion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 SST IAPP GHRL GCG

Sources for Abnormality of Glucagon Secretion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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