MCID: ACL001
MIFTS: 39

Acalculous Cholecystitis

Categories: Gastrointestinal diseases

Aliases & Classifications for Acalculous Cholecystitis

MalaCards integrated aliases for Acalculous Cholecystitis:

Name: Acalculous Cholecystitis 12 45 15 17 74
Acute Cholecystitis Without Calculus 12 74
Acute Acalculous Cholecystitis 12
Cholecystitis Without Calculus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2828
MeSH 45 D042101
NCIt 51 C35578
SNOMED-CT 69 19968009
ICD10 34 K81.9

Summaries for Acalculous Cholecystitis

MalaCards based summary : Acalculous Cholecystitis, also known as acute cholecystitis without calculus, is related to cholecystitis and pancreatitis. An important gene associated with Acalculous Cholecystitis is CCK (Cholecystokinin). The drugs Nefopam and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include breast, liver and bone.

Related Diseases for Acalculous Cholecystitis

Diseases related to Acalculous Cholecystitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 134)
# Related Disease Score Top Affiliating Genes
1 cholecystitis 33.2 CCK GPT
2 pancreatitis 30.5 CCK CRP
3 cholangitis 30.3 CRP GPT
4 acute pancreatitis 30.2 CCK CRP
5 scrub typhus 30.2 CRP GPT
6 hepatitis 10.6
7 systemic lupus erythematosus 10.5
8 lupus erythematosus 10.5
9 leptospirosis 10.5
10 hepatitis a 10.5
11 dengue virus 10.4
12 typhoid fever 10.4
13 dengue disease 10.4
14 pfeiffer syndrome 10.3
15 renal cell carcinoma, nonpapillary 10.3
16 malaria 10.3
17 leukemia 10.3
18 endocarditis 10.3
19 acquired immunodeficiency syndrome 10.3
20 q fever 10.3
21 peritonitis 10.3
22 appendicitis 10.3
23 mirizzi syndrome 10.3
24 cytomegalovirus infection 10.3
25 burns 10.2
26 epidemic typhus 10.2
27 infective endocarditis 10.2
28 lymphocytic leukemia 10.2
29 sclerosing cholangitis 10.2
30 cholera 10.2
31 antiphospholipid syndrome 10.2
32 churg-strauss syndrome 10.2
33 purpura 10.2
34 vasculitis 10.2
35 allergic angiitis 10.2
36 eosinophilic granulomatosis with polyangiitis 10.2
37 paralytic ileus 10.2 CCK CRP
38 bacteremia 2 10.1 CRP GUSB
39 hepatocellular carcinoma 10.1
40 gilbert syndrome 10.1
41 intussusception 10.1
42 ascaris lumbricoides infection 10.1
43 leukemia, acute lymphoblastic 10.1
44 chronic granulomatous disease 10.1
45 dengue hemorrhagic fever 10.1
46 hepatitis b 10.1
47 spinal cord injury 10.1
48 korean hemorrhagic fever 10.1
49 henoch-schoenlein purpura 10.1
50 hemorrhagic fever with renal syndrome 10.1

Graphical network of the top 20 diseases related to Acalculous Cholecystitis:



Diseases related to Acalculous Cholecystitis

Symptoms & Phenotypes for Acalculous Cholecystitis

Drugs & Therapeutics for Acalculous Cholecystitis

Drugs for Acalculous Cholecystitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 212)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Nefopam Approved, Investigational Phase 4 13669-70-0
2
Ketamine Approved, Vet_approved Phase 4,Not Applicable 6740-88-1 3821
3
Remifentanil Approved Phase 4,Not Applicable 132875-61-7 60815
4
Propofol Approved, Investigational, Vet_approved Phase 4,Not Applicable 2078-54-8 4943
5
Amoxicillin Approved, Vet_approved Phase 4,Phase 3 26787-78-0 33613
6
Dexmedetomidine Approved, Vet_approved Phase 4 113775-47-6 5311068 68602
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
8
Lidocaine Approved, Vet_approved Phase 4,Not Applicable 137-58-6 3676
9
Metronidazole Approved Phase 4 443-48-1 4173
10
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
11
Tigecycline Approved Phase 4 220620-09-7 5282044
12
Ceftriaxone Approved Phase 4,Phase 2 73384-59-5 5479530 5361919
13
Ursodeoxycholic acid Approved, Investigational Phase 4,Not Applicable 128-13-2 31401
14
tannic acid Approved Phase 4,Not Applicable 1401-55-4
15
Benzocaine Approved, Investigational Phase 4,Not Applicable 1994-09-7, 94-09-7 2337
16
Aprepitant Approved, Investigational Phase 4 170729-80-3 6918365 151165
17
Palonosetron Approved, Investigational Phase 4 135729-61-2, 135729-56-5, 119904-90-4 148211
18
Fosaprepitant Approved Phase 4 172673-20-0 219090
19
Acetaminophen Approved Phase 4 103-90-2 1983
20
Rocuronium Approved Phase 4 119302-91-9, 143558-00-3 441290
21
Vitamin C Approved, Nutraceutical Phase 4,Not Applicable 50-81-7 54670067 5785
22 Hemostatics Phase 4
23 Coagulants Phase 4
24 Analgesics Phase 4,Phase 2,Not Applicable
25 Anesthetics Phase 4,Phase 2,Phase 3,Not Applicable
26 Anesthetics, Intravenous Phase 4,Not Applicable
27 Excitatory Amino Acids Phase 4,Not Applicable
28 Excitatory Amino Acid Antagonists Phase 4,Not Applicable
29 Anesthetics, Dissociative Phase 4,Not Applicable
30 Analgesics, Non-Narcotic Phase 4,Phase 2
31 Anesthetics, General Phase 4,Not Applicable
32 Central Nervous System Depressants Phase 4,Not Applicable
33 Neurotransmitter Agents Phase 4,Not Applicable
34 Peripheral Nervous System Agents Phase 4,Phase 2,Not Applicable
35 Hypnotics and Sedatives Phase 4,Not Applicable
36 Vitamins Phase 4,Phase 2,Not Applicable
37 Trace Elements Phase 4,Phase 2,Not Applicable
38 Nutrients Phase 4,Phase 2,Not Applicable
39 Protective Agents Phase 4,Phase 2,Not Applicable
40 Antioxidants Phase 4,Not Applicable
41 Micronutrients Phase 4,Phase 2,Not Applicable
42 Gastrointestinal Agents Phase 4,Phase 2,Not Applicable
43 Antiemetics Phase 4,Phase 2,Not Applicable
44 Autonomic Agents Phase 4,Phase 2,Not Applicable
45 Neuromuscular Agents Phase 4,Not Applicable
46 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
47 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable
48 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
49 Adrenergic Agonists Phase 4
50 Narcotics Phase 4,Not Applicable

Interventional clinical trials:

(show top 50) (show all 148)
# Name Status NCT ID Phase Drugs
1 Efficacy and Safety of Floseal for the Haemostasis During Laparoscopic Cholecystectomy in Acute Cholecystitis (GLA) Unknown status NCT01126281 Phase 4
2 Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia Unknown status NCT02493231 Phase 4 Nefopam;Ketamine;Saline
3 Uncovered Self-expandable Metal Stent Versus Double Layer Plastic Stent for Malignant Hilar Stricture Unknown status NCT01125865 Phase 4
4 Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy in Acute Cholecystitis Completed NCT02057679 Phase 4 Amoxicillin clavulanic;Placebo
5 Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy Completed NCT01833819 Phase 4 Dexmedetomidine and lidocaine;Remifentanil
6 DGT Versus TPS in Patients With Initial PD Cannulation by Chance; Prospective Multi-center Study Completed NCT01744847 Phase 4
7 Pain Post Abdominal Laparoscopy Prevention With Arcoxia Completed NCT00565682 Phase 4 etoricoxib 120 mg
8 Vitamin C Efficacy in Reducing Post Operative Pain Completed NCT01322061 Phase 4 Ascorbic Acid
9 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection Completed NCT00195351 Phase 4 tigecycline;ceftriaxone sodium + metronidazole
10 Biliary Metal Stent Study: Metal Stents for Management of Distal Malignant Biliary Obstruction Completed NCT00280709 Phase 4
11 UDCA for Symptomatic Gallstone Disease Completed NCT00161083 Phase 4 ursodeoxycholic acid
12 Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal Infection (cIAI) Completed NCT00230971 Phase 4 tigecycline;ceftriaxone plus metronidazole
13 Covered vs. Uncovered SEMS for Occluded Biliary Metal Stents Completed NCT01315522 Phase 4
14 PALONOSETRON X FOSAPREPITANT IN PONV Recruiting NCT03586817 Phase 4 Palonosetron;Fosaprepitant
15 Deep Versus Moderate Neuromuscular Blockade During Laparoscopic Surgery Enrolling by invitation NCT02812186 Phase 4 Rocuronium
16 Outcome of IV Acetaminophen Use in Laparoscopic Cholecystectomies in Patients at Risk of OSA Withdrawn NCT02056678 Phase 4 acetaminophen, IV preparation
17 Drainage is Not Necessary Procedure After Laparoscopic Cholecystectomy Due to Severe Acute Cholecystitis Unknown status NCT01625247 Phase 3
18 Single Port Access (SPA) Cholecystectomy Versus Standard Laparoscopic Cholecystectomy Unknown status NCT00904865 Phase 2, Phase 3
19 Piperacllin Versus Placebo in Patients Undergoing Surgery for Acute Cholecystitis Completed NCT02619149 Phase 3 Piperacillin-tazobactam combination product;Saline solution
20 Acute Cholecystitis - Early Laparoscopic Surgery Versus Antibiotic Therapy and Delayed Elective Cholecystectomy Completed NCT00447304 Phase 3 moxifloxacin
21 Place of Antibiotics in the Postoperative Acute Lithiasic Cholecystitis Completed NCT01015417 Phase 3 Amoxicillin clavulanic acid
22 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00229060 Phase 3 doripenem
23 Doripenem in the Treatment of Complicated Intra-Abdominal Infections Completed NCT00210938 Phase 3 Doripenem
24 Small-incision Open Cholecystectomy or Laparoscopic Cholecystectomy for Gallbladder Disease Completed NCT00370344 Phase 2, Phase 3
25 Early Antiretroviral Treatment and/or Early Isoniazid Prophylaxis Against Tuberculosis in HIV-infected Adults (ANRS 12136 TEMPRANO) Completed NCT00495651 Phase 3 Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis;Antiretroviral medications;Antiretroviral medications+Isoniazid prophylaxis
26 Surgery Or Lifestyle Intervention for Type 2 Diabetes (SOLID) Completed NCT01040468 Phase 3
27 A Prospective Validation Study of Albumin Kinetics With Tracer 123 I-HSA Completed NCT01686776 Phase 3
28 Comparison of Endoscopic Sphincterotomy Plus Large-balloon Dilatation and Conventional Treatment for Large CBD Stones Completed NCT02592811 Phase 3
29 A Clinical Trial to Assess the Efficacy and Safety of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-383) Completed NCT02550288 Phase 3 Ezetimibe 10 mg;Atorvastatin 10 mg;Placebo for Ezetimibe 10 mg tablet;Placebo for Atorvastatin 10 mg capsule
30 A Clinical Trial to Assess the Long Term Safety and Tolerability of MK-0653C in Japanese Participants With Hypercholesterolemia (MK-0653C-384) Completed NCT02460159 Phase 3 EZ 10 mg/Atorva 20 mg FDC;EZ 10 mg/Atorva 10 mg FDC
31 A Study of the Efficacy and Safety of MK-0653H in Japanese Participants With Hypercholesterolemia (MK-0653H-832) Completed NCT02741245 Phase 3 Ezetimibe 10 mg;Rosuvastatin 2.5 mg;Placebo for Ezetimibe;Placebo for Rosuvastatin
32 BDD With UDCA Therapy After Laparoscopic Cholecystectomy Recruiting NCT03578055 Phase 3 BDD with UDCA;Placebo
33 A Randomized Controlled Trial on EGBD vs PC for Acute Cholecystitis. Active, not recruiting NCT02212717 Phase 2, Phase 3
34 Natural Orifice Transgastric Endoscopic Surgical Removal of the Gallbladder Unknown status NCT01174069 Phase 1, Phase 2
35 Does it Make Sense to Give Postoperative Antibiotics to Patients With an Uncomplicated Acute Cholecystitis Completed NCT00323648 Phase 2 Whether or not giving postoperatively antibiotics to patients with an uncomplicated acute cholecystitis
36 Comparisons of Intravenous Ceftriaxone With Intravenous Moxifloxacin in ERCP Completed NCT02098486 Phase 2 Moxifloxacin;ceftriaxone
37 Prospective Evaluation of the Ablation Therapy With Bipolar Radio Frequency for Nonresectable Bile Duct Cancer Recruiting NCT03679338 Phase 2
38 Safety and Tolerability of Rituxan With Methotrexate and Etanercept or Methotrexate and Adalimumab in Patients With Active Rheumatoid Arthritis Terminated NCT00298272 Phase 2 Placebo;Methotrexate;Etanercept;Adalimumab;Methylprednisolone
39 Near Infrared Fluorescence Cholangiography (NIRF-C) During Cholecystectomy -- Use in Acute Cholecystitis Sub-Study Completed NCT02070627 Phase 1 Indocyanine Green (ICG)
40 Transvaginal Cholecystectomy Using Endoscopic Assistance Withdrawn NCT00815438 Phase 1
41 Acute Cholecystitis: Early Versus Delayed Laparoscopic Cholecystectomy; Randomized Prospective Study Unknown status NCT02130245 Not Applicable
42 Prediction of Postoperative Pain by Injection Pain of Propofol Unknown status NCT03021447
43 Transient ECG Changes in Patients With Acute Biliary Disease Unknown status NCT01706068
44 Effect of Vitamin C on Postoperative Pain After Laparoscopic Cholecystectomy Unknown status NCT02553551 Not Applicable Vitamin C;Placebo
45 Role of the Right Portal Pedicle and Rouviere's Sulcus as an Anatomic Landmark in Laparoscopic Cholecystectomy Unknown status NCT02133027 Not Applicable
46 Exploration of Standard Surgical Indication in Gallbladder Benign Disease Unknown status NCT02951169
47 Efficacy of Proficiency-based Versus Free Laparoscopic Training in Cholecystectomy on a Virtual Reality Simulator Unknown status NCT01615549 Not Applicable
48 Comparison of Single Trocar Cholecystectomy to Standard Laparoscopic Cholecystectomy Unknown status NCT00732550 Not Applicable
49 A Comparison of Robot-assisted Single Site and Laparoscopic Single-incision Cholecystectomy for Benign Gallbladder Unknown status NCT02485392 Not Applicable
50 Prospective Validation of "Cholecystectomy First" Strategy for Gallstone Migration Unknown status NCT02461147

Search NIH Clinical Center for Acalculous Cholecystitis

Cochrane evidence based reviews: acalculous cholecystitis

Genetic Tests for Acalculous Cholecystitis

Anatomical Context for Acalculous Cholecystitis

MalaCards organs/tissues related to Acalculous Cholecystitis:

42
Breast, Liver, Bone, Colon, Spinal Cord, Bone Marrow, Smooth Muscle

Publications for Acalculous Cholecystitis

Articles related to Acalculous Cholecystitis:

(show top 50) (show all 548)
# Title Authors Year
1
Infectious mononucleosis - not always a benign condition: a case report of infectious mononucleosis-associated acute acalculous cholecystitis. ( 29490709 )
2019
2
Acute Acalculous Cholecystitis in Hospitalized Patients With Hematologic Malignancies and Prognostic Importance of Gallbladder Ultrasound Findings. ( 29708270 )
2019
3
Chronic Acalculous Cholecystitis in Children With Biliary Symptoms: Usefulness of Hepatocholescintigraphy. ( 30256266 )
2019
4
Rare case report of acalculous cholecystitis: Gallbladder torsion resulting in rupture. ( 30719303 )
2019
5
Limy bile syndrome presenting as acute acalculous cholecystitis. ( 30948398 )
2019
6
Acalculous Cholecystitis: Is an Elective Interval Cholecystectomy Necessary. ( 28704814 )
2018
7
Acalculous Cholecystitis in a Pediatric Patient With Plasmodium Falciparum Infection: A Case Report and Literature Review. ( 28787387 )
2018
8
Role of percutaneous cholecystostomy for acute acalculous cholecystitis: clinical outcomes of 271 patients. ( 29116391 )
2018
9
Acute acalculous cholecystitis during zika virus infection in an immunocompromised patient. ( 29171859 )
2018
10
An acute acalculous cholecystitis in a returned travel couple. ( 29518083 )
2018
11
Conservative Management of Acalculous Cholecystitis in a Seven-year-old Child. ( 29564197 )
2018
12
Acute acalculous cholecystitis: A new safety risk for patients with MS treated with alemtuzumab. ( 29602912 )
2018
13
Acute acalculous cholecystitis of an intrahepatic gallbladder causing Mirizzi's syndrome. ( 29654105 )
2018
14
Acute Acalculous Cholecystitis in the Setting of Negative Ultrasound and Computed Tomography Scan of the Abdomen. ( 29719745 )
2018
15
Riddle Me This: Acalculous Cholecystitis as an Unusual Complication of Immunoglobulin M Negative Mononucleosis. ( 29930883 )
2018
16
Acute Acalculous Cholecystitis in Burns: A Review. ( 29931066 )
2018
17
A Case of Melioidosis Presenting as Acalculous Cholecystitis. ( 30148016 )
2018
18
Correction to: Acute acalculous cholecystitis determining Mirizzi syndrome: case report and literature review. ( 30165833 )
2018
19
A case of multi-drug resistant ESBL-producing Shigella sonnei acute acalculous cholecystitis and gastroenteritis in a returned traveller. ( 30169854 )
2018
20
A case report of acalculous cholecystitis due to Salmonella paratyphi B. ( 30233740 )
2018
21
Long-term results of percutaneous cholecystostomy for definitive treatment of acute acalculous cholecystitis : a 10-year single-center experience. ( 30350527 )
2018
22
Acute Acalculous Cholecystitis due to primary acute Epstein-Barr virus infection treated with laparoscopic cholecystectomy; a case report. ( 30364603 )
2018
23
Recent advances in management of acalculous cholecystitis. ( 30381792 )
2018
24
Acute acalculous cholecystitis in children. ( 30487697 )
2018
25
Acute Acalculous Cholecystitis in a Previously Healthy Infant ( 30489672 )
2018
26
A rare case of childhood Hepatitis A infection with pleural effusion, acalculous cholecystitis, and ascites. ( 30613565 )
2018
27
Successful treatment using corticosteroid combined antibiotic for acute acalculous cholecystitis patients with systemic lupus erythematosus. ( 28682919 )
2017
28
Is cholecystectomy the treatment of choice for acute acalculous cholecystitis? A systematic review of the literature. ( 28776380 )
2017
29
Acalculous cholecystitis in a female with cardiac device-related infective endocarditis. ( 28987045 )
2017
30
Allopurinol-Induced Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: A Cause of Acalculous Cholecystitis? ( 29057181 )
2017
31
Leptospirosis presenting as acute acalculous cholecystitis. ( 29152269 )
2017
32
Axitinib-induced Pneumatosis Intestinalis and Acute Acalculous Cholecystitis in a Patient With Renal Cell Carcinoma. ( 28039049 )
2017
33
Neutropenic acute acalculous cholecystitis (AAC) in a 12-year-old boy with T-acute lymphoblastic leukemia successfully managed with conservative treatment. ( 28085529 )
2017
34
Acute Acalculous Cholecystitis: A Rare Presentation of Primary Epstein-Barr Virus Infection in Adults-Case Report and Review of the Literature. ( 28194287 )
2017
35
Acute acalculous cholecystitis in patients with systemic lupus erythematosus: A unique form of disease flare. ( 28355987 )
2017
36
Severe Murine Typhus Presenting with Acalculous Cholecystitis: A Case Report and Literature Review. ( 28473857 )
2017
37
Risk factors for poor outcomes of children with acute acalculous cholecystitis. ( 28499592 )
2017
38
Acalculous Cholecystitis in Burn Patients: Is There a Role for Percutaneous Cholecystostomy? ( 28576245 )
2017
39
Hepatitis A with Superadded Salmonella paratyphi A Infection Presenting with Exudative Pleural Effusion and Acalculous Cholecystitis. ( 28667735 )
2017
40
Acute Acalculous Cholecystitis Caused by Giardia lamblia. ( 28674353 )
2017
41
Emergent laparoscopic cholecystectomy for acute acalculous cholecystitis revisited. ( 25904560 )
2016
42
Acute acalculous cholecystitis caused by Hepatitis C: A rare case report. ( 26722714 )
2016
43
Another Report of Acalculous Cholecystitis in a Greek Patient with Infectious Mononucleosis: A Matter of Luck or Genetic Predisposition? ( 26885417 )
2016
44
Disseminated visceral varicella zoster virus presenting with the constellation of colonic pseudo-obstruction, acalculous cholecystitis and syndrome of inappropriate ADH secretion. ( 26899893 )
2016
45
A case of acalculous cholecystitis in the course of dengue fever in a traveller returned from Brazil. ( 27029928 )
2016
46
Henoch-Schönlein purpura complicated by acalculous cholecystitis and intussusception, and following recurrence with appendicitis. ( 27077617 )
2016
47
Acute acalculous cholecystitis in a Lebanese girl with primary Epstein-Barr viral infection. ( 27090538 )
2016
48
Hepatobiliary and Pancreatic: Acute acalculous cholecystitis in systemic lupus erythematosus, successfully treated with corticosteroid. ( 27131230 )
2016
49
Acute acalculous cholecystitis in systemic lupus erythematosus: a rare initial manifestation. ( 27267533 )
2016
50
Acute acalculous cholecystitis as a rare manifestation of chronic mesenteric ischemia. A case report. ( 27394394 )
2016

Variations for Acalculous Cholecystitis

Expression for Acalculous Cholecystitis

Search GEO for disease gene expression data for Acalculous Cholecystitis.

Pathways for Acalculous Cholecystitis

GO Terms for Acalculous Cholecystitis

Cellular components related to Acalculous Cholecystitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perikaryon GO:0043204 8.96 CCK GRIK2
2 terminal bouton GO:0043195 8.62 CCK GRIK2

Sources for Acalculous Cholecystitis

3 CDC
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10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
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45 MeSH
46 MESH via Orphanet
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50 NCI
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55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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