MCID: ACN019
MIFTS: 31

Acanthamoeba Keratitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Acanthamoeba Keratitis

MalaCards integrated aliases for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 52 17 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 71 C0000880

Summaries for Acanthamoeba Keratitis

MalaCards based summary : Acanthamoeba Keratitis is related to vasculitis and retinal artery occlusion. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Polihexanide and Dibrompropamidine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Wikipedia : 74 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye, and affects... more...

Related Diseases for Acanthamoeba Keratitis

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 122)
# Related Disease Score Top Affiliating Genes
1 vasculitis 29.7 MBL2 APOH
2 retinal artery occlusion 29.6 F5 APOH
3 granulomatous amebic encephalitis 11.5
4 keratitis, hereditary 11.4
5 herpes simplex 10.7
6 fungal keratitis 10.7
7 corneal ulcer 10.6
8 corneal disease 10.6
9 scleritis 10.6
10 uveitis 10.5
11 cataract 10.5
12 iridocyclitis 10.5
13 hypopyon 10.4
14 corneal edema 10.4
15 mature cataract 10.4
16 corneal neovascularization 10.4
17 neuritis 10.4
18 eye disease 10.4
19 amoebic keratitis 10.4
20 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.4
21 yemenite deaf-blind hypopigmentation syndrome 10.4
22 corneal abscess 10.4
23 myopia 10.4
24 herpes simplex virus keratitis 10.3
25 endophthalmitis 10.3
26 conjunctivitis 10.3
27 dacryoadenitis 10.3
28 keratoconus 10.3
29 superficial keratitis 10.3
30 keratopathy 10.3
31 keratoconjunctivitis 10.3
32 infective keratitis 10.3
33 dry eye syndrome 10.2
34 punctate epithelial keratoconjunctivitis 10.2
35 cholera 10.2
36 chorioretinitis 10.2
37 autoimmune disease 10.0
38 neutrophil migration 10.0
39 uncombable hair syndrome 1 10.0
40 immune deficiency disease 10.0
41 proteasome-associated autoinflammatory syndrome 1 10.0
42 3-methylglutaconic aciduria, type iii 10.0
43 astigmatism 10.0
44 intraocular pressure quantitative trait locus 10.0
45 pulmonary hypertension 10.0
46 ptosis 10.0
47 neuroretinitis 10.0
48 suppression amblyopia 10.0
49 amblyopia 10.0
50 allergic conjunctivitis 10.0

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to Acanthamoeba Keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

Drugs & Therapeutics for Acanthamoeba Keratitis

Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 51)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polihexanide Approved, Investigational Phase 3 28757-47-3
2 Dibrompropamidine Experimental Phase 3 496-00-4
3
Propamidine Experimental, Investigational Phase 3 104-32-5
4 Anti-Infective Agents Phase 3
5 Hypoglycemic Agents Phase 3
6 Pharmaceutical Solutions Phase 3
7 Antiparasitic Agents Phase 3
8 Antiprotozoal Agents Phase 3
9 Anti-Infective Agents, Local Phase 3
10 Biguanides Phase 3
11 Ophthalmic Solutions Phase 3
12 Disinfectants Phase 3
13
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
14
Iodine Approved, Investigational Phase 2 7553-56-2 807
15
Povidone Approved Phase 2 9003-39-8
16
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
17
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
18 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
19
Povidone-iodine Approved Phase 2 25655-41-8
20
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
21
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
22 Antiemetics Phase 2
23 Gastrointestinal Agents Phase 2
24 Lubricant Eye Drops Phase 2
25 Methylprednisolone Acetate Phase 2
26 Chlorhexidine gluconate Phase 2
27 Plasma Substitutes Phase 2
28 Nutrients Phase 2
29 Hormone Antagonists Phase 2
30 Neuroprotective Agents Phase 2
31 Dermatologic Agents Phase 2
32 Blood Substitutes Phase 2
33 Trace Elements Phase 2
34 Autonomic Agents Phase 2
35 Protective Agents Phase 2
36 Anti-Inflammatory Agents Phase 2
37 Antineoplastic Agents, Hormonal Phase 2
38 glucocorticoids Phase 2
39 cadexomer iodine Phase 2
40 Micronutrients Phase 2
41 Hormones Phase 2
42
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
43
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
44
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
45
Tobramycin Approved, Investigational 32986-56-4 5496 36294
46 Tobramycin, Dexamethasone Drug Combination
47 BB 1101
48 Immunosuppressive Agents
49 Anti-Bacterial Agents
50 Calcineurin Inhibitors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized, Active-Controlled, Phase 3 Study to Evaluate Efficacy, Safety and Tolerability of 0.08% PHMB Ophthalmic Solution in Comparison With 0.02% PHMB + 0.1% Propamidine Combination Therapy in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
2 Parasitic Ulcer Treatment Trial Pilot Recruiting NCT03484507 Phase 2 Chlorhexidine;Povidone-Iodine;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose
3 Randomized, Double-Masked, Placebo-Controlled Multiple-Dose Phase 1 Study to Evaluate the Safety and Tolerability of Different Doses of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
4 Retrospective Study of the in Vivo Confocal Microscopic Findings and the Treatment Outcome of Acanthamoebic Keratitis Unknown status NCT02763605
5 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Recruiting NCT03105466 Tacrolimus eye drops;Tobradex eyedrops
6 Microbiologic Alterations of the Conjunctiva of Hot Tub-soaking Ophthalmologists Recruiting NCT03987178
7 Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures - a Pilot Study Enrolling by invitation NCT03461978

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ketoconazole

Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

MalaCards organs/tissues related to Acanthamoeba Keratitis:

40
Eye, Testes, Skin, Retina, Thymus, Brain, Cortex

Publications for Acanthamoeba Keratitis

Articles related to Acanthamoeba Keratitis:

(show top 50) (show all 1077)
# Title Authors PMID Year
1
Clinical features and serial changes of Acanthamoeba keratitis: an in vivo confocal microscopy study. 61
31292523 2020
2
Antiamoebic activity of plant-based natural products and their conjugated silver nanoparticles against Acanthamoeba castellanii (ATCC 50492). 61
32016777 2020
3
Histone Deacetylase Inhibitors Enhance the Amoebicidal Effect of Low Concentration of Polyhexamethylene Biguanide by Inducing Apoptosis. 61
31724982 2020
4
Extracellular protease profile of Acanthamoeba after prolonged axenic culture and after interaction with MDCK cells. 61
31848745 2020
5
Combination of tert-butyl hydroperoxide with vorinostat induces cell death of Acanthamoeba through cell cycle arrest. 61
31935358 2020
6
In Vitro Amoebicidal Activity of Imidazolium Salts Against Trophozoites. 61
31939031 2020
7
Controlled In Vitro Delivery of Voriconazole and Diclofenac to the Cornea using Contact Lenses for the Treatment of Acanthamoeba Keratitis. 61
32007592 2020
8
Clinical features and outcomes of Acanthamoeba keratitis in a tertiary hospital over 20- year period. 61
31076316 2020
9
Penetrating keratoplasty with Krumeich ring for corneal leukoma secondary to Acanthamoeba keratitis. 61
31973972 2020
10
Experimental keratitis in rats caused by Acanthamoeba griffini: A kinetic histopathological study. 61
31856305 2019
11
Increasing incidence of Acanthamoeba keratitis in a large tertiary ophthalmology department from year 1994 to 2018. 61
31885189 2019
12
Role of in vivo confocal microscopy in the diagnosis of infectious keratitis. 61
31209694 2019
13
Therapeutic penetrating keratoplasty for acanthamoeba keratitis: a review of cases, complications and predictive factors. 61
31214859 2019
14
Oral miltefosine for refractory Acanthamoeba keratitis. 61
31650083 2019
15
Resolution of Acanthamoeba Keratitis with Adjunctive Use of Oral Miltefosine. 61
31829774 2019
16
Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba. 61
31499180 2019
17
[Acanthamoeba endophthalmitis-a case report]. 61
31768616 2019
18
Epipremnum aureum Keratopathy: Case Report and Review of the Literature. 61
31794541 2019
19
Synergy Testing of Antiamoebic Agents for Acanthamoeba: Antagonistic Effect of Voriconazole. 61
31306283 2019
20
Analysis from a year of increased cases of Acanthamoeba Keratitis in a large teaching hospital in the UK. 61
31018907 2019
21
The role of extracellular matrix in mouse and human corneal neovascularization. 61
31582785 2019
22
The First Acanthamoeba keratitis Case of Non-Contact Lens Wearer with HIV Infection in Thailand. 61
31715691 2019
23
Therapeutic penetrating keratoplasty for microbial keratitis in Taiwan from 2001 to 2014. 61
31635845 2019
24
Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review. 61
31554948 2019
25
Clinical course of Acanthamoeba keratitis by genotypes T4 and T8 in Hungary. 61
30835133 2019
26
Early Penetrating Keratoplasty À Chaud May Improve Outcome in Therapy-Resistant Acanthamoeba Keratitis. 61
31317392 2019
27
High fluence PACK-CXL as adjuvant treatment for advanced Acanthamoeba keratitis. 61
31312750 2019
28
Acanthamoeba keratitis related to contact lens use in a tertiary hospital in China. 61
31533675 2019
29
Contact Lens Versus Non-Contact Lens-Related Corneal Ulcers at an Academic Center. 61
31442212 2019
30
Corticosteroid eye drop instillation aggravates the development of Acanthamoeba keratitis in rabbit corneas inoculated with Acanthamoeba and bacteria. 61
31492880 2019
31
Reduction of Acanthamoeba Cyst Density Associated With Treatment Detected by In Vivo Confocal Microscopy in Acanthamoeba Keratitis. 61
31169613 2019
32
Acanthamoeba keratitis therapy: time to cure and visual outcome analysis for different antiamoebic therapies in 227 cases. 61
31401556 2019
33
[Diagnostic value of fungal fluorescence staining on corneal scrapings for fungal keratitis]. 61
31422639 2019
34
Efficient therapeutic effect of Nigella sativa aqueous extract and chitosan nanoparticles against experimentally induced Acanthamoeba keratitis. 61
31144032 2019
35
Effectiveness of sampling methods employed for Acanthamoeba keratitis diagnosis by culture. 61
29916123 2019
36
Ultrasound-Enhanced Drug Delivery for Treatment of Acanthamoeba Keratitis. 61
31946406 2019
37
Oral Miltefosine as Adjunctive Treatment for Recalcitrant Acanthamoeba Keratitis. 61
31170106 2019
38
Acanthamoeba Keratitis. 61
31314971 2019
39
Corneal Endotheliitis as a Presentation of Acanthamoeba Keratitis. 61
31219868 2019
40
Water Exposure and the Risk of Contact Lens-Related Disease. 61
30789440 2019
41
Synthesis and in vitro activity of new biguanide-containing dendrimers on pathogenic isolates of Acanthamoeba polyphaga and Acanthamoeba griffini. 61
31069536 2019
42
Cobalt nanoparticles as novel nanotherapeutics against Acanthamoeba castellanii. 61
31159839 2019
43
Torn from the headlines: role of public awareness and bench- to-bedside research in prevention and treatment of Acanthamoeba keratitis. 61
30552420 2019
44
Notes from the Field: Acanthamoeba Keratitis Cases - Iowa, 2002-2017. 61
31095535 2019
45
[Infectious keratitis in contact lens wearers]. 61
31120209 2019
46
The Acanthamoeba-Fungal Keratitis Study. 61
30721687 2019
47
Efficacy of Topical Miltefosine in Patients with Acanthamoeba Keratitis: A Pilot Study. 61
30572075 2019
48
Reduction of Acanthamoeba Cyst Density Associated With Treatment Detected by In Vivo Confocal Microscopy in Acanthamoeba Keratitis. 61
30640249 2019
49
Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review. 61
30963963 2019
50
Evidence of human-like Ca2+ channels and effects of Ca2+ channel blockers in Acanthamoeba castellanii. 61
30362253 2019

Variations for Acanthamoeba Keratitis

Expression for Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for Acanthamoeba Keratitis

Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 MBL2 F5

GO Terms for Acanthamoeba Keratitis

Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 MBL2 F5 CXCL2 APOH
2 extracellular space GO:0005615 8.92 MBL2 F5 CXCL2 APOH

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 F5 APOH

Sources for Acanthamoeba Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....