MCID: ACN019
MIFTS: 41

Acanthamoeba Keratitis

Categories: Eye diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Acanthamoeba Keratitis

MalaCards integrated aliases for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 54 60 17 74

Characteristics:

Orphanet epidemiological data:

60
acanthamoeba keratitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

MESH via Orphanet 46 D015823
ICD10 via Orphanet 35 B60.1+ H19.2*
UMLS via Orphanet 75 C0000880
Orphanet 60 ORPHA67043
UMLS 74 C0000880

Summaries for Acanthamoeba Keratitis

MalaCards based summary : Acanthamoeba Keratitis is related to keratitis, hereditary and cataract. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Polihexanide and Propamidine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin, and related phenotypes are photophobia and ocular pain

Wikipedia : 77 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye, and affects... more...

Related Diseases for Acanthamoeba Keratitis

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 11.3
2 cataract 10.3
3 herpes simplex 10.3
4 dacryoadenitis 10.3
5 herpes simplex virus keratitis 10.2
6 keratoconjunctivitis 10.2
7 fungal keratitis 10.2
8 uncombable hair syndrome 1 10.0
9 sjogren syndrome 10.0
10 pulmonary hypertension 10.0
11 keratoconus 10.0
12 keratopathy 10.0
13 trachoma 10.0
14 corneal neovascularization 10.0
15 scleral staphyloma 10.0
16 myopia 10.0
17 sympathetic ophthalmia 10.0
18 shipyard eye 10.0
19 plague 10.0
20 endophthalmitis 10.0
21 chronic fatigue syndrome 10.0
22 chorioretinitis 10.0
23 cytokine deficiency 10.0
24 stromal keratitis 10.0
25 may-thurner syndrome 9.9 APOH F5
26 spinal cord infarction 9.9 APOH F5
27 sudden sensorineural hearing loss 9.9 APOH F5
28 cerebral sinovenous thrombosis 9.9 APOH F5
29 thrombosis 9.9 APOH F5
30 pregnancy loss, recurrent 1 9.9 APOH F5
31 prothrombin deficiency, congenital 9.9 APOH F5
32 ischemic colitis 9.9 APOH F5
33 catastrophic antiphospholipid syndrome 9.9 APOH F5
34 antiphospholipid syndrome 9.9 APOH F5
35 retinal vascular occlusion 9.9 APOH F5
36 thrombophlebitis 9.9 APOH F5
37 carotid artery occlusion 9.9 APOH F5
38 antithrombin iii deficiency 9.9 APOH F5
39 peripheral vertigo 9.9 APOH F5
40 central retinal vein occlusion 9.9 APOH F5
41 retinal vein occlusion 9.9 APOH F5
42 intracranial thrombosis 9.9 APOH F5
43 factor xii deficiency 9.9 APOH F5
44 legg-calve-perthes disease 9.9 APOH F5
45 retinal artery occlusion 9.9 APOH F5
46 portal vein thrombosis 9.9 APOH F5
47 protein s deficiency 9.9 APOH F5
48 placental abruption 9.9 APOH F5
49 ischemic optic neuropathy 9.9 APOH F5
50 intracranial hypertension 9.8 APOH F5

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to Acanthamoeba Keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

Human phenotypes related to Acanthamoeba Keratitis:

60 33 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 60 33 hallmark (90%) Very frequent (99-80%) HP:0000613
2 ocular pain 60 33 hallmark (90%) Very frequent (99-80%) HP:0200026
3 punctate opacification of the cornea 60 33 hallmark (90%) Very frequent (99-80%) HP:0007856
4 cataract 60 33 frequent (33%) Frequent (79-30%) HP:0000518
5 decreased corneal sensation 60 33 frequent (33%) Frequent (79-30%) HP:0012155
6 corneal perforation 60 33 frequent (33%) Frequent (79-30%) HP:0100583
7 scleritis 60 33 frequent (33%) Frequent (79-30%) HP:0100532
8 iris atrophy 60 33 frequent (33%) Frequent (79-30%) HP:0001089
9 anterior uveitis 60 33 frequent (33%) Frequent (79-30%) HP:0012122
10 abnormal posterior eye segment morphology 33 frequent (33%) HP:0004329
11 corneal stromal edema 60 33 occasional (7.5%) Occasional (29-5%) HP:0012040
12 corneal ulceration 60 33 occasional (7.5%) Occasional (29-5%) HP:0012804
13 abnormal anterior chamber morphology 33 occasional (7.5%) HP:0000593
14 abnormality of the anterior chamber 60 Occasional (29-5%)
15 abnormality of the cornea 60 Very frequent (99-80%)
16 abnormality of corneal epithelium 60 Very frequent (99-80%)
17 abnormality of the posterior segment of the globe 60 Frequent (79-30%)

Drugs & Therapeutics for Acanthamoeba Keratitis

Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polihexanide Approved, Investigational Phase 3,Phase 1 28757-47-3
2
Propamidine Experimental, Investigational Phase 3 104-32-5
3 Dibrompropamidine Experimental Phase 3 496-00-4
4 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
5 Disinfectants Phase 3,Phase 2,Phase 1
6 Biguanides Phase 3,Phase 1
7 Hypoglycemic Agents Phase 3,Phase 1
8 Ophthalmic Solutions Phase 3,Phase 1,Not Applicable
9 Pharmaceutical Solutions Phase 3,Phase 1,Not Applicable
10 Antiparasitic Agents Phase 3
11 Antiprotozoal Agents Phase 3
12 Anti-Infective Agents, Local Phase 3,Phase 2
13
Iodine Approved, Investigational Phase 2 7553-56-2 807
14
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
15
Povidone Approved Phase 2 9003-39-8
16
Povidone-iodine Approved Phase 2 25655-41-8
17
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
18
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
19
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
20
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 2713 9552079
21
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
22 Lubricant Eye Drops Phase 2
23 Dermatologic Agents Phase 2
24 Anti-Inflammatory Agents Phase 2,Not Applicable
25 Prednisolone acetate Phase 2
26 Plasma Substitutes Phase 2
27 Hormone Antagonists Phase 2,Not Applicable
28 Peripheral Nervous System Agents Phase 2
29 Gastrointestinal Agents Phase 2
30 Nutrients Phase 2
31 Micronutrients Phase 2
32 Blood Substitutes Phase 2
33 Methylprednisolone Acetate Phase 2
34 glucocorticoids Phase 2,Not Applicable
35 Chlorhexidine gluconate Phase 2
36 Autonomic Agents Phase 2
37 Trace Elements Phase 2
38 Antiemetics Phase 2
39 Hormones Phase 2,Not Applicable
40 cadexomer iodine Phase 2
41 Antineoplastic Agents, Hormonal Phase 2
42 Protective Agents Phase 2
43 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2,Not Applicable
44 Neuroprotective Agents Phase 2
45
Tacrolimus Approved, Investigational Not Applicable 104987-11-3 6473866 445643 439492
46
Dexamethasone acetate Approved, Investigational, Vet_approved Not Applicable 1177-87-3
47
Dexamethasone Approved, Investigational, Vet_approved Not Applicable 50-02-2 5743
48
Tobramycin Approved, Investigational Not Applicable 32986-56-4 36294 5496
49 BB 1101 Not Applicable
50 Immunologic Factors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
2 Parasitic Ulcer Treatment Trial Pilot Recruiting NCT03484507 Phase 2 Chlorhexidine;Povidone-Iodine;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose
3 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
4 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Unknown status NCT02763605
5 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Recruiting NCT03105466 Not Applicable Tacrolimus eye drops;Tobradex eyedrops
6 Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures Enrolling by invitation NCT03461978 Not Applicable

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

MalaCards organs/tissues related to Acanthamoeba Keratitis:

42
Eye, Testes, Skin, Retina, Spinal Cord, Placenta

Publications for Acanthamoeba Keratitis

Articles related to Acanthamoeba Keratitis:

(show top 50) (show all 559)
# Title Authors Year
1
Drug targeting in Acanthamoeba keratitis: rational of using drugs that are already approved for ocular use in non-keratitis indications. ( 30356128 )
2019
2
Notes from the Field: Acanthamoeba Keratitis Cases - Iowa, 2002-2017. ( 31095535 )
2019
3
Clinical features and outcomes of Acanthamoeba keratitis in a tertiary hospital over 20- year period. ( 31076316 )
2019
4
Analysis from a year of increased cases of Acanthamoeba Keratitis in a large teaching hospital in the UK. ( 31018907 )
2019
5
Acanthamoeba keratitis - Clinical signs, differential diagnosis and treatment. ( 30899841 )
2019
6
Clinical course of Acanthamoeba keratitis by genotypes T4 and T8 in Hungary. ( 30835133 )
2019
7
Accelerated collagen cross-linking in the management of advanced Acanthamoeba keratitis. ( 30726402 )
2019
8
Genotypic diversity of Acanthamoeba strains isolated from Chilean patients with Acanthamoeba keratitis. ( 30683157 )
2019
9
Reduction of Acanthamoeba Cyst Density Associated With Treatment Detected by In Vivo Confocal Microscopy in Acanthamoeba Keratitis. ( 30640249 )
2019
10
Efficacy of Topical Miltefosine in Patients with Acanthamoeba Keratitis: A Pilot Study. ( 30572075 )
2019
11
Risk Factors for Acanthamoeba Keratitis-A Multistate Case-Control Study, 2008-2011. ( 28099282 )
2018
12
Confocal microscopy as an early relapse marker for acanthamoeba keratitis. ( 28556202 )
2018
13
Risk factors, demographics and clinical profile of Acanthamoeba keratitis in Melbourne: an 18-year retrospective study. ( 28844988 )
2018
14
Case Report: Acanthamoeba Keratitis Management in a First-trimester Pregnant Patient. ( 29554009 )
2018
15
The use of miltefosine in the management of refractory Acanthamoeba keratitis. ( 29580956 )
2018
16
Evaluation of voriconazole anti-Acanthamoeba polyphaga in vitro activity, rat cornea penetration and efficacy against experimental rat Acanthamoeba keratitis. ( 29596605 )
2018
17
Tap Water and Risk of Acanthamoeba Keratitis in Rigid Gas Permeable Lens Wearers: Sacred Cow or Culprit: Erratum. ( 29688957 )
2018
18
Acanthamoeba keratitis: current status and urgent research priorities. ( 29745319 )
2018
19
Acanthamoeba Keratitis: Are Recent Cases More Severe? ( 29847494 )
2018
20
Acanthamoeba keratitis: An emerging disease among microbial keratitis in the Cap Bon region of Tunisia. ( 29859227 )
2018
21
A report of 10 patients with Acanthamoeba keratitis. ( 29885816 )
2018
22
Effectiveness of sampling methods employed for Acanthamoeba keratitis diagnosis by culture. ( 29916123 )
2018
23
Effect of ethanol pretreatment in Acanthamoeba keratitis: a long-term follow-up study. ( 30013376 )
2018
24
Prevention of Acanthamoeba keratitis in contact lens wearers: is the message getting through? ( 30133903 )
2018
25
Comparison of anterior segment optical coherence tomography findings in acanthamoeba keratitis and herpetic epithelial keratitis. ( 30140650 )
2018
26
Acanthamoeba keratitis: confirmation of the UK outbreak and a prospective case-control study identifying contributing risk factors. ( 30232172 )
2018
27
Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation. ( 30232207 )
2018
28
The first Acanthamoeba keratitis case in the Midwest region of Brazil: diagnosis, genotyping of the parasite and disease outcome. ( 30304286 )
2018
29
Corneal "Plaque" formation after anti-acanthamoeba therapy in acanthamoeba keratitis. ( 30355882 )
2018
30
Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome. ( 30472333 )
2018
31
Torn from the headlines: role of public awareness and bench- to-bedside research in prevention and treatment of Acanthamoeba keratitis. ( 30552420 )
2018
32
Dual 0.02% chlorhexidine digluconate - 0.1% disodium EDTA loaded thermosensitive ocular gel for Acanthamoeba keratitis treatment. ( 30553004 )
2018
33
Total necrosis of cornea, iris and crystalline lens with exposure of vitreous hyaloid face in the context of recalcitrant acanthamoeba keratitis. ( 30555975 )
2018
34
Pythium insidiosum and Acanthamoeba keratitis in a contact lens user. ( 30567163 )
2018
35
Risk factors and clinical signs of severe Acanthamoeba keratitis. ( 30573947 )
2018
36
In Vivo Confocal Microscopy Cellular Features of Host and Organism in Bacterial, Fungal, and Acanthamoeba Keratitis. ( 29550185 )
2018
37
Regional spread of contact lens-related Acanthamoeba keratitis in Italy. ( 29505068 )
2018
38
Treatment of intraocular spread of acanthamoeba after tectonic corneal graft in acanthamoeba keratitis. ( 29472699 )
2018
39
Tap Water and Risk of Acanthamoeba Keratitis in Rigid Gas-Permeable Lens Wearers: Sacred Cow or Culprit? ( 29462055 )
2018
40
The rising tide of Acanthamoeba keratitis in Auckland, New Zealand: a 7-year review of presentation, diagnosis and outcomes (2009-2016). ( 29412494 )
2018
41
Can artificial tears prevent Acanthamoeba keratitis? An in vitro approach. ( 29357901 )
2018
42
Acanthamoeba keratitis in Porto Alegre (southern Brazil): 28 cases and risk factors. ( 29332157 )
2018
43
Factors Influencing the Diagnostic Accuracy of Laser-Scanning In Vivo Confocal Microscopy for Acanthamoeba Keratitis. ( 29303889 )
2018
44
Acanthamoeba keratitis in 194 patients: risk factors for bad outcomes and severe inflammatory complications. ( 29298778 )
2018
45
Comparison of In Vivo Confocal Microscopy, PCR and Culture of Corneal Scrapes in the Diagnosis of Acanthamoeba Keratitis. ( 29256983 )
2018
46
Acanthamoeba keratitis in patients wearing scleral contact lenses. ( 29221710 )
2018
47
Acanthamoeba keratitis in noncompliant soft contact lenses users: Genotyping and risk factors, a study from Cairo, Egypt. ( 28965795 )
2018
48
Assessment of Confocal Microscopy for the Diagnosis of Polymerase Chain Reaction-Positive Acanthamoeba Keratitis: A Case-Control Study. ( 28965660 )
2018
49
Nanoemulsions Containing a Coumarin-Rich Extract from Pterocaulon balansae (Asteraceae) for the Treatment of Ocular Acanthamoeba Keratitis. ( 27225384 )
2017
50
Specificity of in vivo confocal cornea microscopy in Acanthamoeba keratitis. ( 27312210 )
2017

Variations for Acanthamoeba Keratitis

Expression for Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for Acanthamoeba Keratitis

Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.77 F5 MBL2

GO Terms for Acanthamoeba Keratitis

Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 APOH CXCL2 F5 MBL2
2 extracellular space GO:0005615 8.92 APOH CXCL2 F5 MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 APOH F5

Sources for Acanthamoeba Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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