MCID: ACN019
MIFTS: 40

Acanthamoeba Keratitis

Categories: Rare diseases, Infectious diseases

Aliases & Classifications for Acanthamoeba Keratitis

MalaCards integrated aliases for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 53 59 73

Characteristics:

Orphanet epidemiological data:

59
acanthamoeba keratitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:

Orphanet: 59  
Rare infectious diseases


External Ids:

Orphanet 59 ORPHA67043
MESH via Orphanet 45 D015823
ICD10 via Orphanet 34 B60.1+ H19.2*
UMLS via Orphanet 74 C0000880
UMLS 73 C0000880

Summaries for Acanthamoeba Keratitis

MalaCards based summary : Acanthamoeba Keratitis is related to cataract and dacryoadenitis. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Propamidine and Tetrahydrozoline have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and testes, and related phenotypes are photophobia and punctate opacification of the cornea

Wikipedia : 76 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye. It may result in... more...

Related Diseases for Acanthamoeba Keratitis

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 cataract 10.1
2 dacryoadenitis 10.1
3 may-thurner syndrome 10.1 APOH F5
4 spinal cord infarction 10.1 APOH F5
5 livedoid vasculopathy 10.1 APOH F5
6 cerebral sinovenous thrombosis 10.1 APOH F5
7 pregnancy loss, recurrent 1 10.1 APOH F5
8 prothrombin deficiency, congenital 10.1 APOH F5
9 ischemic colitis 10.1 APOH F5
10 catastrophic antiphospholipid syndrome 10.1 APOH F5
11 sneddon syndrome 10.1 APOH F5
12 retinal artery occlusion 10.1 APOH F5
13 intracranial thrombosis 10.1 APOH F5
14 retinal vascular occlusion 10.1 APOH F5
15 thrombophlebitis 10.0 APOH F5
16 prothrombin deficiency 10.0 APOH F5
17 carotid artery occlusion 10.0 APOH F5
18 antithrombin iii deficiency 10.0 APOH F5
19 herpes simplex 10.0
20 keratoconjunctivitis 10.0
21 peripheral vertigo 10.0 APOH F5
22 central retinal vein occlusion 10.0 APOH F5
23 factor xii deficiency 10.0 APOH F5
24 portal vein thrombosis 10.0 APOH F5
25 protein s deficiency 10.0 APOH F5
26 placental abruption 10.0 APOH F5
27 ischemic optic neuropathy 10.0 APOH F5
28 intracranial hypertension 10.0 APOH F5
29 retinal vein occlusion 10.0 APOH F5
30 thrombophilia due to activated protein c resistance 9.9 APOH F5
31 placenta disease 9.9 APOH F5
32 severe pre-eclampsia 9.9 APOH F5
33 thrombophilia due to thrombin defect 9.9 APOH F5
34 budd-chiari syndrome 9.9 APOH F5
35 uncombable hair syndrome 1 9.9
36 pulmonary hypertension 9.9
37 keratoconus 9.9
38 keratopathy 9.9
39 herpes simplex virus keratitis 9.9
40 mucositis 9.9
41 trachoma 9.9
42 corneal neovascularization 9.9
43 myopia 9.9
44 sympathetic ophthalmia 9.9
45 shipyard eye 9.9
46 plague 9.9
47 endophthalmitis 9.9
48 conjunctivitis 9.9
49 chronic fatigue syndrome 9.9
50 chorioretinitis 9.9

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to Acanthamoeba Keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

Human phenotypes related to Acanthamoeba Keratitis:

59 32 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 photophobia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000613
2 punctate opacification of the cornea 59 32 hallmark (90%) Very frequent (99-80%) HP:0007856
3 ocular pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0200026
4 cataract 59 32 frequent (33%) Frequent (79-30%) HP:0000518
5 iris atrophy 59 32 frequent (33%) Frequent (79-30%) HP:0001089
6 anterior uveitis 59 32 frequent (33%) Frequent (79-30%) HP:0012122
7 decreased corneal sensation 59 32 frequent (33%) Frequent (79-30%) HP:0012155
8 scleritis 59 32 frequent (33%) Frequent (79-30%) HP:0100532
9 corneal perforation 59 32 frequent (33%) Frequent (79-30%) HP:0100583
10 corneal stromal edema 59 32 occasional (7.5%) Occasional (29-5%) HP:0012040
11 corneal ulceration 59 32 occasional (7.5%) Occasional (29-5%) HP:0012804
12 abnormality of the cornea 59 Very frequent (99-80%)
13 abnormality of corneal epithelium 59 Very frequent (99-80%)
14 abnormality of the posterior segment of the globe 59 Frequent (79-30%)
15 abnormality of the anterior chamber 59 Occasional (29-5%)
16 abnormal anterior chamber morphology 32 occasional (7.5%) HP:0000593
17 abnormal morphology of the posterior segment of the globe 32 frequent (33%) HP:0004329

Drugs & Therapeutics for Acanthamoeba Keratitis

Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 22)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Propamidine Experimental, Investigational Phase 3 104-32-5
2 Tetrahydrozoline Phase 3,Phase 1,Not Applicable
3 Ophthalmic Solutions Phase 3,Phase 1,Not Applicable
4 Disinfectants Phase 3,Phase 1
5 Hypoglycemic Agents Phase 3,Phase 1
6 Pharmaceutical Solutions Phase 3,Phase 1,Not Applicable
7 Polyhexamethylene biguanide Phase 3,Phase 1
8 Anti-Infective Agents Phase 3,Phase 1
9 Dibrompropamidine Phase 3
10 Anti-Infective Agents, Local Phase 3
11 Antiparasitic Agents Phase 3
12 Antiprotozoal Agents Phase 3
13
Ephedrine Approved Phase 1,Not Applicable 299-42-3 9294
14
Pseudoephedrine Approved Phase 1,Not Applicable 90-82-4 7028
15 Respiratory System Agents Phase 1,Not Applicable
16 Nasal Decongestants Phase 1,Not Applicable
17 Vasoconstrictor Agents Phase 1,Not Applicable
18 Peripheral Nervous System Agents Phase 1,Not Applicable
19 Autonomic Agents Phase 1,Not Applicable
20
Tacrolimus Approved, Investigational Not Applicable 104987-11-3 445643 439492
21 Immunosuppressive Agents Not Applicable
22 Calcineurin Inhibitors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
2 Parasitic Ulcer Treatment Trial Pilot Recruiting NCT03484507 Phase 2 Chlorhexidine;Povidone-Iodine;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose
3 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
4 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Unknown status NCT02763605
5 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Recruiting NCT03105466 Not Applicable Tacrolimus eye drops;Tobradex eyedrops
6 Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures Enrolling by invitation NCT03461978 Not Applicable

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

MalaCards organs/tissues related to Acanthamoeba Keratitis:

41
Eye, Retina, Testes

Publications for Acanthamoeba Keratitis

Articles related to Acanthamoeba Keratitis:

(show top 50) (show all 532)
# Title Authors Year
1
Acanthamoeba keratitis: An emerging disease among microbial keratitis in the Cap Bon region of Tunisia. ( 29859227 )
2018
2
Acanthamoeba keratitis in Porto Alegre (southern Brazil): 28 cases and risk factors. ( 29332157 )
2018
3
The rising tide of Acanthamoeba keratitis in Auckland, New Zealand: a 7-year review of presentation, diagnosis and outcomes (2009-2016). ( 29412494 )
2018
4
A report of 10 patients with Acanthamoeba keratitis. ( 29885816 )
2018
5
Acanthamoeba Keratitis: Are Recent Cases More Severe? ( 29847494 )
2018
6
Tap Water and Risk of Acanthamoeba Keratitis in Rigid Gas-Permeable Lens Wearers: Sacred Cow or Culprit? ( 29462055 )
2018
7
Regional spread of contact lens-related Acanthamoeba keratitis in Italy. ( 29505068 )
2018
8
Factors Influencing the Diagnostic Accuracy of Laser-Scanning In Vivo Confocal Microscopy for Acanthamoeba Keratitis. ( 29303889 )
2018
9
The use of miltefosine in the management of refractory Acanthamoeba keratitis. ( 29580956 )
2018
10
Can artificial tears prevent Acanthamoeba keratitis? An in vitro approach. ( 29357901 )
2018
11
InA Vivo Confocal Microscopy Cellular Features of Host and Organism in Bacterial, Fungal, and Acanthamoeba Keratitis. ( 29550185 )
2018
12
Assessment of Confocal Microscopy for the Diagnosis of Polymerase Chain Reaction-Positive Acanthamoeba Keratitis: A Case-Control Study. ( 28965660 )
2018
13
Treatment of intraocular spread of acanthamoeba after tectonic corneal graft in acanthamoeba keratitis. ( 29472699 )
2018
14
Evaluation of voriconazole anti-Acanthamoeba polyphaga in vitro activity, rat cornea penetration and efficacy against experimental rat Acanthamoeba keratitis. ( 29596605 )
2018
15
Case Report: Acanthamoeba Keratitis Management in a First-trimester Pregnant Patient. ( 29554009 )
2018
16
Tap Water and Risk of Acanthamoeba Keratitis in Rigid Gas Permeable Lens Wearers: Sacred Cow or Culprit: Erratum. ( 29688957 )
2018
17
Effectiveness of sampling methods employed for Acanthamoeba keratitis diagnosis by culture. ( 29916123 )
2018
18
Acanthamoeba keratitis: current status and urgent research priorities. ( 29745319 )
2018
19
Tear Cytokine Levels in Contact Lens Wearers With Acanthamoeba Keratitis. ( 28489721 )
2017
20
Risk factors, demographics and clinical profile of Acanthamoeba keratitis in Melbourne: an 18-year retrospective study. ( 28844988 )
2017
21
In-vitro development of an effective treatment for Acanthamoeba keratitis. ( 28709990 )
2017
22
Risk Factors for Acanthamoeba Keratitis-A Multistate Case-Control Study, 2008-2011. ( 28099282 )
2017
23
Rapid resolution of stromal keratitis with the assistance of oral voriconazole in resistant acanthamoeba keratitis. ( 29296556 )
2017
24
A case of non-Acanthamoeba keratitis with radial keratoneuritis. ( 28861362 )
2017
25
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28079686 )
2017
26
Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Modelsa8c. ( 28656012 )
2017
27
Confocal microscopy as an early relapse marker for acanthamoeba keratitis. ( 28556202 )
2017
28
Associated factors, diagnosis and management of Acanthamoeba keratitis in a referral Center in Southern China. ( 28969610 )
2017
29
Molecular diagnosis of Acanthamoeba keratitis: evaluation in rat model and application in suspected human cases. ( 28251314 )
2017
30
A Rabbit Model of Acanthamoeba Keratitis: Use of Infected Soft Contact Lenses After Corneal Epithelium Debridement With a Diamond Burr. ( 28241309 )
2017
31
Risk factors and clinical features of Acanthamoeba keratitis in a Tunisian tertiary eye care center. ( 28964757 )
2017
32
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28691946 )
2017
33
Quantitative Analysis of Depth, Distribution, and Density of Cysts in Acanthamoeba Keratitis Using Confocal Microscopy. ( 28542085 )
2017
34
First time identification of Acanthamoeba genotypes in the cornea samples of wild birds; Is Acanthamoeba keratitis making the predatory birds a target? ( 28807756 )
2017
35
Evaluation of loop-mediated isothermal amplification assay for rapid diagnosis of Acanthamoeba keratitis. ( 28303825 )
2017
36
Results with the Boston Type I keratoprosthesis after Acanthamoeba keratitis. ( 29260063 )
2017
37
Acanthamoeba keratitis in noncompliant soft contact lenses users: Genotyping and risk factors, a study from Cairo, Egypt. ( 28965795 )
2017
38
Acanthamoeba keratitis in patients wearing scleral contact lenses. ( 29221710 )
2017
39
Comparison of In Vivo Confocal Microscopy, PCR and Culture of Corneal Scrapes in the Diagnosis of Acanthamoeba Keratitis. ( 29256983 )
2017
40
Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis: Case report of aA patient with SjAPgren's syndrome. ( 28386159 )
2017
41
In vivo confocal microscopy and in vitro culture techniques as tools for evaluation of severe Acanthamoeba keratitis incidents ( 29420872 )
2017
42
The use of dimethyl sulfoxide in contact lens disinfectants is a potential preventative strategy against contracting Acanthamoeba keratitis. ( 27133448 )
2016
43
The Impact of Topical Corticosteroids Used in Conjunction with Antiamoebic Therapy on the Outcome of Acanthamoeba Keratitis. ( 26952591 )
2016
44
Dacryoadenitis and extraocular muscle inflammation associated with contact lens-related Acanthamoeba keratitis: A case report and review of the literature. ( 27874294 )
2016
45
Early Deep Anterior Lamellar Keratoplasty (DALK) for Acanthamoeba Keratitis-How to Define Early? ( 27032028 )
2016
46
Specificity of in vivo confocal cornea microscopy in Acanthamoeba keratitis. ( 27312210 )
2016
47
Strategies for the prevention of contact lens-related Acanthamoeba keratitis: a review. ( 26691018 )
2016
48
Painless Acanthamoeba Keratitis with Normal Vision. ( 27870779 )
2016
49
Keratoneuritis is not pathognomonic of Acanthamoeba keratitis: a case report of Pseudomonas keratitis. ( 27003712 )
2016
50
Laboratory diagnosis of Acanthamoeba keratitis in Hungary. ( 27576919 )
2016

Variations for Acanthamoeba Keratitis

Expression for Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for Acanthamoeba Keratitis

Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.77 F5 MBL2

GO Terms for Acanthamoeba Keratitis

Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 APOH CXCL2 F5 MBL2
2 extracellular space GO:0005615 8.92 APOH CXCL2 F5 MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 APOH F5

Sources for Acanthamoeba Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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