MCID: ACN019
MIFTS: 42

Acanthamoeba Keratitis

Categories: Eye diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Acanthamoeba Keratitis

MalaCards integrated aliases for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 53 59 73

Characteristics:

Orphanet epidemiological data:

59
acanthamoeba keratitis
Inheritance: Not applicable; Prevalence: 1-9/100000 (Europe); Age of onset: All ages; Age of death: normal life expectancy;

Classifications:



External Ids:

Orphanet 59 ORPHA67043
MESH via Orphanet 45 D015823
ICD10 via Orphanet 34 B60.1+ H19.2*
UMLS via Orphanet 74 C0000880
UMLS 73 C0000880

Summaries for Acanthamoeba Keratitis

MalaCards based summary : Acanthamoeba Keratitis is related to keratitis, hereditary and cataract. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Polihexanide and Propamidine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin, and related phenotypes are cataract and photophobia

Wikipedia : 76 Acanthamoeba keratitis is a rare disease in which amoebae invade the cornea of the eye, and affects... more...

Related Diseases for Acanthamoeba Keratitis

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 10.6
2 cataract 10.2
3 herpes simplex 10.2
4 dacryoadenitis 10.2
5 herpes simplex virus keratitis 10.2
6 keratoconjunctivitis 10.2
7 fungal keratitis 10.2
8 may-thurner syndrome 10.0 APOH F5
9 spinal cord infarction 10.0 APOH F5
10 sudden sensorineural hearing loss 10.0 APOH F5
11 cerebral sinovenous thrombosis 10.0 APOH F5
12 thrombosis 10.0 APOH F5
13 pregnancy loss, recurrent 1 10.0 APOH F5
14 prothrombin deficiency, congenital 10.0 APOH F5
15 ischemic colitis 10.0 APOH F5
16 catastrophic antiphospholipid syndrome 10.0 APOH F5
17 antiphospholipid syndrome 10.0 APOH F5
18 retinal vascular occlusion 10.0 APOH F5
19 thrombophlebitis 10.0 APOH F5
20 carotid artery occlusion 10.0 APOH F5
21 antithrombin iii deficiency 10.0 APOH F5
22 uncombable hair syndrome 1 10.0
23 pulmonary hypertension 10.0
24 keratoconus 10.0
25 keratopathy 10.0
26 trachoma 10.0
27 corneal neovascularization 10.0
28 myopia 10.0
29 sympathetic ophthalmia 10.0
30 shipyard eye 10.0
31 plague 10.0
32 endophthalmitis 10.0
33 chronic fatigue syndrome 10.0
34 chorioretinitis 10.0
35 stromal keratitis 10.0
36 peripheral vertigo 10.0 APOH F5
37 central retinal vein occlusion 10.0 APOH F5
38 retinal vein occlusion 10.0 APOH F5
39 intracranial thrombosis 10.0 APOH F5
40 factor xii deficiency 10.0 APOH F5
41 legg-calve-perthes disease 10.0 APOH F5
42 retinal artery occlusion 10.0 APOH F5
43 portal vein thrombosis 10.0 APOH F5
44 protein s deficiency 10.0 APOH F5
45 placental abruption 10.0 APOH F5
46 ischemic optic neuropathy 10.0 APOH F5
47 intracranial hypertension 10.0 APOH F5
48 thrombophilia 10.0 APOH F5
49 thrombophilia due to activated protein c resistance 10.0 APOH F5
50 placenta disease 10.0 APOH F5

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to Acanthamoeba Keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

Human phenotypes related to Acanthamoeba Keratitis:

59 32 (show all 17)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 cataract 59 32 frequent (33%) Frequent (79-30%) HP:0000518
2 photophobia 59 32 hallmark (90%) Very frequent (99-80%) HP:0000613
3 ocular pain 59 32 hallmark (90%) Very frequent (99-80%) HP:0200026
4 corneal stromal edema 59 32 occasional (7.5%) Occasional (29-5%) HP:0012040
5 decreased corneal sensation 59 32 frequent (33%) Frequent (79-30%) HP:0012155
6 corneal perforation 59 32 frequent (33%) Frequent (79-30%) HP:0100583
7 scleritis 59 32 frequent (33%) Frequent (79-30%) HP:0100532
8 punctate opacification of the cornea 59 32 hallmark (90%) Very frequent (99-80%) HP:0007856
9 iris atrophy 59 32 frequent (33%) Frequent (79-30%) HP:0001089
10 anterior uveitis 59 32 frequent (33%) Frequent (79-30%) HP:0012122
11 corneal ulceration 59 32 occasional (7.5%) Occasional (29-5%) HP:0012804
12 abnormality of the anterior chamber 59 Occasional (29-5%)
13 abnormality of the cornea 59 Very frequent (99-80%)
14 abnormality of corneal epithelium 59 Very frequent (99-80%)
15 abnormality of the posterior segment of the globe 59 Frequent (79-30%)
16 abnormal anterior chamber morphology 32 occasional (7.5%) HP:0000593
17 abnormal morphology of the posterior segment of the globe 32 frequent (33%) HP:0004329

Drugs & Therapeutics for Acanthamoeba Keratitis

Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polihexanide Approved, Investigational Phase 3,Phase 1 28757-47-3
2
Propamidine Experimental, Investigational Phase 3 104-32-5
3 Biguanides Phase 3,Phase 1
4 Ophthalmic Solutions Phase 3,Phase 1,Not Applicable
5 Hypoglycemic Agents Phase 3,Phase 1
6 Pharmaceutical Solutions Phase 3,Phase 1,Not Applicable
7 Disinfectants Phase 3,Phase 2,Phase 1
8 Anti-Infective Agents Phase 3,Phase 2,Phase 1
9 Antiprotozoal Agents Phase 3
10 Anti-Infective Agents, Local Phase 3,Phase 2
11 Dibrompropamidine Phase 3
12 Antiparasitic Agents Phase 3
13
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
14
Povidone-iodine Approved Phase 2 25655-41-8
15
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
16
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
17
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
18
Povidone Approved Phase 2 9003-39-8
19
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 2713 9552079
20
Iodine Approved, Investigational Phase 2 7553-56-2 807
21
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
22 Methylprednisolone acetate Phase 2
23 Chlorhexidine gluconate Phase 2
24 Autonomic Agents Phase 2
25 Neuroprotective Agents Phase 2
26 Prednisolone acetate Phase 2
27 Hormones Phase 2
28 Hormone Antagonists Phase 2
29 Micronutrients Phase 2
30 cadexomer iodine Phase 2
31 Gastrointestinal Agents Phase 2
32 Dermatologic Agents Phase 2
33 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
34 Antiemetics Phase 2
35 Plasma Substitutes Phase 2
36 Anti-Inflammatory Agents Phase 2
37 Lubricant Eye Drops Phase 2
38 Antineoplastic Agents, Hormonal Phase 2
39 Trace Elements Phase 2
40 glucocorticoids Phase 2
41 Peripheral Nervous System Agents Phase 2
42 Blood Substitutes Phase 2
43 Protective Agents Phase 2
44
Tacrolimus Approved, Investigational Not Applicable 104987-11-3 445643 439492
45 Immunosuppressive Agents Not Applicable
46 Calcineurin Inhibitors Not Applicable
47 Immunologic Factors Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
2 Parasitic Ulcer Treatment Trial Pilot Recruiting NCT03484507 Phase 2 Chlorhexidine;Povidone-Iodine;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose
3 Safety and Tolerability of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
4 Retrospective Study of Acanthamoebic Keratitis During the Past 10 Years Unknown status NCT02763605
5 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Recruiting NCT03105466 Not Applicable Tacrolimus eye drops;Tobradex eyedrops
6 Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures Enrolling by invitation NCT03461978 Not Applicable

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

MalaCards organs/tissues related to Acanthamoeba Keratitis:

41
Eye, Testes, Skin, Retina, Spinal Cord, Placenta

Publications for Acanthamoeba Keratitis

Articles related to Acanthamoeba Keratitis:

(show top 50) (show all 546)
# Title Authors Year
1
Acanthamoeba keratitis: An emerging disease among microbial keratitis in the Cap Bon region of Tunisia. ( 29859227 )
2018
2
Acanthamoeba keratitis in Porto Alegre (southern Brazil): 28 cases and risk factors. ( 29332157 )
2018
3
The rising tide of Acanthamoeba keratitis in Auckland, New Zealand: a 7-year review of presentation, diagnosis and outcomes (2009-2016). ( 29412494 )
2018
4
A report of 10 patients with Acanthamoeba keratitis. ( 29885816 )
2018
5
Acanthamoeba Keratitis: Are Recent Cases More Severe? ( 29847494 )
2018
6
Tap Water and Risk of Acanthamoeba Keratitis in Rigid Gas-Permeable Lens Wearers: Sacred Cow or Culprit? ( 29462055 )
2018
7
Regional spread of contact lens-related Acanthamoeba keratitis in Italy. ( 29505068 )
2018
8
Factors Influencing the Diagnostic Accuracy of Laser-Scanning In Vivo Confocal Microscopy for Acanthamoeba Keratitis. ( 29303889 )
2018
9
The use of miltefosine in the management of refractory Acanthamoeba keratitis. ( 29580956 )
2018
10
Can artificial tears prevent Acanthamoeba keratitis? An in vitro approach. ( 29357901 )
2018
11
InA Vivo Confocal Microscopy Cellular Features of Host and Organism in Bacterial, Fungal, and Acanthamoeba Keratitis. ( 29550185 )
2018
12
Assessment of Confocal Microscopy for the Diagnosis of Polymerase Chain Reaction-Positive Acanthamoeba Keratitis: A Case-Control Study. ( 28965660 )
2018
13
Treatment of intraocular spread of acanthamoeba after tectonic corneal graft in acanthamoeba keratitis. ( 29472699 )
2018
14
Evaluation of voriconazole anti-Acanthamoeba polyphaga in vitro activity, rat cornea penetration and efficacy against experimental rat Acanthamoeba keratitis. ( 29596605 )
2018
15
Case Report: Acanthamoeba Keratitis Management in a First-trimester Pregnant Patient. ( 29554009 )
2018
16
Tap Water and Risk of Acanthamoeba Keratitis in Rigid Gas Permeable Lens Wearers: Sacred Cow or Culprit: Erratum. ( 29688957 )
2018
17
Effectiveness of sampling methods employed for Acanthamoeba keratitis diagnosis by culture. ( 29916123 )
2018
18
Acanthamoeba keratitis: current status and urgent research priorities. ( 29745319 )
2018
19
Effect of ethanol pretreatment in Acanthamoeba keratitis: a long-term follow-up study. ( 30013376 )
2018
20
Prevention of Acanthamoeba keratitis in contact lens wearers: is the message getting through? ( 30133903 )
2018
21
Comparison of anterior segment optical coherence tomography findings in acanthamoeba keratitis and herpetic epithelial keratitis. ( 30140650 )
2018
22
Acanthamoeba keratitis: confirmation of the UK outbreak and a prospective case-control study identifying contributing risk factors. ( 30232172 )
2018
23
Herpes simplex virus keratitis mimicking Acanthamoeba keratitis: a clinicopathological correlation. ( 30232207 )
2018
24
The first Acanthamoeba keratitis case in the Midwest region of Brazil: diagnosis, genotyping of the parasite and disease outcome. ( 30304286 )
2018
25
Corneal "Plaque" formation after anti-acanthamoeba therapy in acanthamoeba keratitis. ( 30355882 )
2018
26
Drug targeting in Acanthamoeba keratitis: rational of using drugs that are already approved for ocular use in non-keratitis indications. ( 30356128 )
2018
27
Acanthamoeba keratitis in Mexico: Report of a clinical case and importance of sensitivity assays for a better outcome. ( 30472333 )
2018
28
Torn from the headlines: role of public awareness and bench- to-bedside research in prevention and treatment of Acanthamoeba keratitis. ( 30552420 )
2018
29
Dual 0.02% chlorhexidine digluconate - 0.1% disodium EDTA loaded thermosensitive ocular gel for Acanthamoeba keratitis treatment. ( 30553004 )
2018
30
Total necrosis of cornea, iris and crystalline lens with exposure of vitreous hyaloid face in the context of recalcitrant acanthamoeba keratitis. ( 30555975 )
2018
31
Tear Cytokine Levels in Contact Lens Wearers With Acanthamoeba Keratitis. ( 28489721 )
2017
32
Risk factors, demographics and clinical profile of Acanthamoeba keratitis in Melbourne: an 18-year retrospective study. ( 28844988 )
2017
33
In-vitro development of an effective treatment for Acanthamoeba keratitis. ( 28709990 )
2017
34
Risk Factors for Acanthamoeba Keratitis-A Multistate Case-Control Study, 2008-2011. ( 28099282 )
2017
35
Rapid resolution of stromal keratitis with the assistance of oral voriconazole in resistant acanthamoeba keratitis. ( 29296556 )
2017
36
A case of non-Acanthamoeba keratitis with radial keratoneuritis. ( 28861362 )
2017
37
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28079686 )
2017
38
Pathobiology and Immunobiology of Acanthamoeba Keratitis: Insights from Animal Modelsa8c. ( 28656012 )
2017
39
Confocal microscopy as an early relapse marker for acanthamoeba keratitis. ( 28556202 )
2017
40
Associated factors, diagnosis and management of Acanthamoeba keratitis in a referral Center in Southern China. ( 28969610 )
2017
41
Molecular diagnosis of Acanthamoeba keratitis: evaluation in rat model and application in suspected human cases. ( 28251314 )
2017
42
A Rabbit Model of Acanthamoeba Keratitis: Use of Infected Soft Contact Lenses After Corneal Epithelium Debridement With a Diamond Burr. ( 28241309 )
2017
43
Risk factors and clinical features of Acanthamoeba keratitis in a Tunisian tertiary eye care center. ( 28964757 )
2017
44
Number of Bacteria and Time of Coincubation With Bacteria Required for the Development of Acanthamoeba Keratitis. ( 28691946 )
2017
45
Quantitative Analysis of Depth, Distribution, and Density of Cysts in Acanthamoeba Keratitis Using Confocal Microscopy. ( 28542085 )
2017
46
First time identification of Acanthamoeba genotypes in the cornea samples of wild birds; Is Acanthamoeba keratitis making the predatory birds a target? ( 28807756 )
2017
47
Evaluation of loop-mediated isothermal amplification assay for rapid diagnosis of Acanthamoeba keratitis. ( 28303825 )
2017
48
Results with the Boston Type I keratoprosthesis after Acanthamoeba keratitis. ( 29260063 )
2017
49
Acanthamoeba keratitis in noncompliant soft contact lenses users: Genotyping and risk factors, a study from Cairo, Egypt. ( 28965795 )
2017
50
Acanthamoeba keratitis in patients wearing scleral contact lenses. ( 29221710 )
2017

Variations for Acanthamoeba Keratitis

Expression for Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for Acanthamoeba Keratitis

Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.77 F5 MBL2

GO Terms for Acanthamoeba Keratitis

Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 APOH CXCL2 F5 MBL2
2 extracellular space GO:0005615 8.92 APOH CXCL2 F5 MBL2

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 APOH F5

Sources for Acanthamoeba Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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