MCID: ACN019
MIFTS: 31

Acanthamoeba Keratitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Acanthamoeba Keratitis

MalaCards integrated aliases for Acanthamoeba Keratitis:

Name: Acanthamoeba Keratitis 52 17 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases


External Ids:

UMLS 71 C0000880

Summaries for Acanthamoeba Keratitis

MalaCards based summary : Acanthamoeba Keratitis is related to vasculitis and retinal artery occlusion. An important gene associated with Acanthamoeba Keratitis is APOH (Apolipoprotein H), and among its related pathways/superpathways is Complement and coagulation cascades. The drugs Polihexanide and Propamidine have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and skin.

Wikipedia : 74 Acanthamoeba keratitis is a rare disease in which amoebae of the genus Acanthamoeba invade the clear... more...

Related Diseases for Acanthamoeba Keratitis

Diseases related to Acanthamoeba Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 126)
# Related Disease Score Top Affiliating Genes
1 vasculitis 29.7 MBL2 APOH
2 retinal artery occlusion 29.6 F5 APOH
3 granulomatous amebic encephalitis 11.5
4 keratitis, hereditary 11.4
5 herpes simplex 10.7
6 fungal keratitis 10.7
7 corneal ulcer 10.6
8 corneal disease 10.6
9 scleritis 10.6
10 uveitis 10.5
11 hypopyon 10.5
12 cataract 10.5
13 iridocyclitis 10.5
14 corneal edema 10.4
15 mature cataract 10.4
16 amoebic keratitis 10.4
17 corneal neovascularization 10.4
18 neuritis 10.4
19 eye disease 10.4
20 yemenite deaf-blind hypopigmentation syndrome 10.4
21 joint laxity, short stature, and myopia 10.4
22 corneal abscess 10.4
23 myopia 10.4
24 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.3
25 herpes simplex virus keratitis 10.3
26 endophthalmitis 10.3
27 conjunctivitis 10.3
28 dacryoadenitis 10.3
29 keratoconus 10.3
30 superficial keratitis 10.3
31 keratopathy 10.3
32 keratoconjunctivitis 10.3
33 infective keratitis 10.3
34 dry eye syndrome 10.2
35 sclerosing keratitis 10.2
36 cholera 10.2
37 chorioretinitis 10.2
38 autoimmune disease 10.0
39 neutrophil migration 10.0
40 uncombable hair syndrome 1 10.0
41 immune deficiency disease 10.0
42 proteasome-associated autoinflammatory syndrome 1 10.0
43 3-methylglutaconic aciduria, type iii 10.0
44 astigmatism 10.0
45 intraocular pressure quantitative trait locus 10.0
46 pulmonary hypertension 10.0
47 ptosis 10.0
48 neuroretinitis 10.0
49 suppression amblyopia 10.0
50 amblyopia 10.0

Graphical network of the top 20 diseases related to Acanthamoeba Keratitis:



Diseases related to Acanthamoeba Keratitis

Symptoms & Phenotypes for Acanthamoeba Keratitis

Drugs & Therapeutics for Acanthamoeba Keratitis

Drugs for Acanthamoeba Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 46)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Polihexanide Approved, Investigational Phase 3 28757-47-3
2
Propamidine Experimental, Investigational Phase 3 104-32-5
3 Dibrompropamidine Experimental Phase 3 496-00-4
4 Anti-Infective Agents Phase 3
5 Pharmaceutical Solutions Phase 3
6 Hypoglycemic Agents Phase 3
7 Ophthalmic Solutions Phase 3
8 Anti-Infective Agents, Local Phase 3
9 Antiparasitic Agents Phase 3
10 Antiprotozoal Agents Phase 3
11 Disinfectants Phase 3
12 Biguanides Phase 3
13
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
14
Chlorhexidine Approved, Vet_approved Phase 2 55-56-1 9552079 2713
15
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
16
Iodine Approved, Investigational Phase 2 7553-56-2 807
17
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
18
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
19
Povidone-iodine Approved Phase 2 25655-41-8
20 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
21
Povidone Approved Phase 2 9003-39-8
22
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
23 Hormones Phase 2
24 Antineoplastic Agents, Hormonal Phase 2
25 Methylprednisolone Acetate Phase 2
26 Hormone Antagonists Phase 2
27 glucocorticoids Phase 2
28 Chlorhexidine gluconate Phase 2
29 Antiemetics Phase 2
30 Neuroprotective Agents Phase 2
31 Lubricant Eye Drops Phase 2
32 Gastrointestinal Agents Phase 2
33 Protective Agents Phase 2
34 Plasma Substitutes Phase 2
35 cadexomer iodine Phase 2
36 Anti-Inflammatory Agents Phase 2
37 Blood Substitutes Phase 2
38
Tacrolimus Approved, Investigational 104987-11-3 445643 439492 6473866
39
Dexamethasone acetate Approved, Investigational, Vet_approved 1177-87-3
40
Tobramycin Approved, Investigational 32986-56-4 36294 5496
41
Dexamethasone Approved, Investigational, Vet_approved 50-02-2 5743
42 Tobramycin, Dexamethasone Drug Combination
43 Immunosuppressive Agents
44 Anti-Bacterial Agents
45 Calcineurin Inhibitors
46 Immunologic Factors

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Randomized, Active-Controlled, Phase 3 Study to Evaluate Efficacy, Safety and Tolerability of 0.08% PHMB Ophthalmic Solution in Comparison With 0.02% PHMB + 0.1% Propamidine Combination Therapy in Subjects Affected by Acanthamoeba Keratitis Recruiting NCT03274895 Phase 3 PHMB 0.08%;Propamidine 0.1%;placebo;PHMB 0.02%
2 Parasitic Ulcer Treatment Trial Pilot Recruiting NCT03484507 Phase 2 Chlorhexidine;Povidone-Iodine;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose;Prednisolone Sodium Phosphate;Hydroxypropyl Methylcellulose
3 Randomized, Double-Masked, Placebo-Controlled Multiple-Dose Phase 1 Study to Evaluate the Safety and Tolerability of Different Doses of Preservative-free Polyhexamethylene Biguanide (PHMB) Ophthalmic Solution in Healthy Subjects Completed NCT02506257 Phase 1 0.04% PHMB;0.06% PHMB;0.08% PHMB;PHMB Vehicle
4 Retrospective Study of the in Vivo Confocal Microscopic Findings and the Treatment Outcome of Acanthamoebic Keratitis Unknown status NCT02763605
5 Prospective Study of Deep Anterior Lamellar Keratoplasty Using Acellular Porcine Cornea Unknown status NCT03105466 Tacrolimus eye drops;Tobradex eyedrops
6 Microbiologic Alterations of the Conjunctiva of Hot Tub-soaking Ophthalmologists Recruiting NCT03987178
7 Ultrahigh-resolution Optical Coherence Tomography Imaging of the Anterior Eye Segment Structures - a Pilot Study Enrolling by invitation NCT03461978

Search NIH Clinical Center for Acanthamoeba Keratitis

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Ketoconazole

Genetic Tests for Acanthamoeba Keratitis

Anatomical Context for Acanthamoeba Keratitis

MalaCards organs/tissues related to Acanthamoeba Keratitis:

40
Eye, Testes, Skin, Retina, Thymus, Brain, Cortex

Publications for Acanthamoeba Keratitis

Articles related to Acanthamoeba Keratitis:

(show top 50) (show all 1103)
# Title Authors PMID Year
1
Case series: Delayed diagnoses of Acanthamoeba keratitis. 61
32566802 2020
2
A 5-Year Review of Acanthamoeba Keratitis Related to Wearing Contact Lenses in Korea. 61
32443003 2020
3
An Original Use of a Bioluminescence Assay to Test the In Vitro Efficacy of Polihexanide in the Eradication of Acanthamoeba Cysts. 61
32195752 2020
4
In Vitro Amoebicidal Activity of Imidazolium Salts Against Trophozoites. 61
31939031 2020
5
Identification of N-acyl quinolin-2(1H)-ones as new selective agents against clinical isolates of Acanthamoeba keratitis. 61
32247111 2020
6
Use of white light in vivo confocal microscopy for the detection of spatial changes in the corneal nerves in cases of early-stage Acanthamoeba keratitis with radial keratoneuritis. 61
32461430 2020
7
Therapeutic penetrating keratoplasty for microbial keratitis in Taiwan from 2001 to 2014. 61
31635845 2020
8
[Chameleon-Like Corneal Disorders: Acanthamoeba Keratitis]. 61
32428962 2020
9
Antiamoebic activity of synthetic tetrazoles against Acanthamoeba castellanii belonging to T4 genotype and effects of conjugation with silver nanoparticles. 61
32385711 2020
10
Acanthamoeba Keratitis Versus Mixed Acanthamoeba and Bacterial Keratitis: Comparison of Clinical and Microbiological Profiles. 61
32452992 2020
11
Systemic Miltefosine as an Adjunct Treatment of Progressive Acanthamoeba Keratitis. 61
32469616 2020
12
Development and assessment of a simulator for in vivo confocal microscopy in fungal and acanthamoeba keratitis. 61
32434387 2020
13
Silver Nanoparticles as a Novel Potential Preventive Agent against Acanthamoeba Keratitis. 61
32380785 2020
14
Contact lens-related corneal infection in Australia. 61
32363626 2020
15
Metformin-coated silver nanoparticles exhibit anti-acanthamoebic activities against both trophozoite and cyst stages. 61
32461112 2020
16
Alkyl-carbon chain length of two distinct compounds and derivatives are key determinants of their anti-Acanthamoeba activities. 61
32286337 2020
17
Acanthamoeba spp. in river water samples from the Black Sea region, Turkey. 61
32300091 2020
18
In vitro activity of isavuconazole against three species of Acanthamoeba. 61
32151474 2020
19
Acanthamoeba keratitis therapy: time to cure and visual outcome analysis for different antiamoebic therapies in 227 cases. 61
31401556 2020
20
Controlled in vitro delivery of voriconazole and diclofenac to the cornea using contact lenses for the treatment of Acanthamoeba keratitis. 61
32007592 2020
21
In vivo confocal microscopy morphological features and cyst density in Acanthamoeba keratitis. 61
32278770 2020
22
Acanthamoeba keratitis in Australia: demographics, associated factors, presentation and outcomes: a 15-year case review. 61
31554948 2020
23
Outcome of therapeutic deep anterior lamellar keratoplasty in advanced Acanthamoeba keratitis. 61
32056998 2020
24
Management of severe Acanthamoeba keratitis and complicated cataract following laser in situ keratomileusis. 61
32057016 2020
25
Penetrating keratoplasty with Krumeich ring for corneal leukoma secondary to Acanthamoeba keratitis. 61
31973972 2020
26
Experimental keratitis in rats caused by Acanthamoeba griffini: A kinetic histopathological study. 61
31856305 2020
27
Topical Voriconazole as Supplemental Treatment for Acanthamoeba Keratitis. 61
32243421 2020
28
[Necrotizing scleritis after acanthamoeba keratitis]. 61
32162088 2020
29
Prevalence and seasonal variation of Acanthamoeba in domestic tap water in greater Sydney, Australia. 61
32227362 2020
30
Antioxidant defense in the eyes of immunocompetent and immunosuppressed mice infected with Acanthamoeba spp. 61
32143731 2020
31
Combination of tert-butyl hydroperoxide with vorinostat induces cell death of Acanthamoeba through cell cycle arrest. 61
31935358 2020
32
Antiamoebic activity of plant-based natural products and their conjugated silver nanoparticles against Acanthamoeba castellanii (ATCC 50492). 61
32016777 2020
33
Histone Deacetylase Inhibitors Enhance the Amoebicidal Effect of Low Concentration of Polyhexamethylene Biguanide by Inducing Apoptosis. 61
31724982 2020
34
Extracellular protease profile of Acanthamoeba after prolonged axenic culture and after interaction with MDCK cells. 61
31848745 2020
35
Rose Bengal-Mediated Photodynamic Antimicrobial Treatment of Acanthamoeba Keratitis. 61
32065854 2020
36
Clinical features and serial changes of Acanthamoeba keratitis: an in vivo confocal microscopy study. 61
31292523 2020
37
The relationship between environmental sources and the susceptibility of Acanthamoeba keratitis in the United Kingdom. 61
32160218 2020
38
Clinical features and outcomes of Acanthamoeba keratitis in a tertiary hospital over 20- year period. 61
31076316 2020
39
Tear Inflammatory Molecules in Contact Lens Wearers: A Literature Review. 61
30963963 2020
40
Antimicrobial Photodynamic Therapy with the photosensitizer TONS504 eradicates Acanthamoeba. 61
31499180 2019
41
Increasing incidence of Acanthamoeba keratitis in a large tertiary ophthalmology department from year 1994 to 2018. 61
31885189 2019
42
Role of in vivo confocal microscopy in the diagnosis of infectious keratitis. 61
31209694 2019
43
Therapeutic penetrating keratoplasty for acanthamoeba keratitis: a review of cases, complications and predictive factors. 61
31214859 2019
44
Resolution of Acanthamoeba Keratitis with Adjunctive Use of Oral Miltefosine. 61
31829774 2019
45
Oral miltefosine for refractory Acanthamoeba keratitis. 61
31650083 2019
46
Epipremnum aureum Keratopathy: Case Report and Review of the Literature. 61
31794541 2019
47
[Acanthamoeba endophthalmitis-a case report]. 61
31768616 2019
48
Analysis from a year of increased cases of Acanthamoeba Keratitis in a large teaching hospital in the UK. 61
31018907 2019
49
The role of extracellular matrix in mouse and human corneal neovascularization. 61
31582785 2019
50
Synergy Testing of Antiamoebic Agents for Acanthamoeba: Antagonistic Effect of Voriconazole. 61
31306283 2019

Variations for Acanthamoeba Keratitis

Expression for Acanthamoeba Keratitis

Search GEO for disease gene expression data for Acanthamoeba Keratitis.

Pathways for Acanthamoeba Keratitis

Pathways related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.78 MBL2 F5

GO Terms for Acanthamoeba Keratitis

Cellular components related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.26 MBL2 F5 CXCL2 APOH
2 extracellular space GO:0005615 8.92 MBL2 F5 CXCL2 APOH

Biological processes related to Acanthamoeba Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet degranulation GO:0002576 8.62 F5 APOH

Sources for Acanthamoeba Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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