MCID: ACN004
MIFTS: 26

Acantholytic Acanthoma

Categories: Cancer diseases

Aliases & Classifications for Acantholytic Acanthoma

MalaCards integrated aliases for Acantholytic Acanthoma:

Name: Acantholytic Acanthoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4324
NCIt 49 C27517
SNOMED-CT 67 397188008
UMLS 71 C1301270

Summaries for Acantholytic Acanthoma

MalaCards based summary : Acantholytic Acanthoma is related to clear cell acanthoma and acanthoma. An important gene associated with Acantholytic Acanthoma is CCDC39 (Coiled-Coil Domain Containing 39), and among its related pathways/superpathways are CREB Pathway and Sertoli-Sertoli Cell Junction Dynamics. Affiliated tissues include skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Acantholytic Acanthoma

Graphical network of the top 20 diseases related to Acantholytic Acanthoma:



Diseases related to Acantholytic Acanthoma

Symptoms & Phenotypes for Acantholytic Acanthoma

GenomeRNAi Phenotypes related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.53 ALK NF1 RAF1 TGFBR1
2 Decreased viability GR00221-A-2 9.53 NF1 RAF1
3 Decreased viability GR00221-A-4 9.53 ALK NF1 TGFBR1
4 Decreased viability GR00249-S 9.53 ALK NF1 TGFBR1
5 Decreased viability GR00301-A 9.53 RAF1
6 Decreased viability GR00386-A-1 9.53 NF1
7 Decreased viability GR00402-S-2 9.53 RAF1 TGFBR1
8 Decreased substrate adherent cell growth GR00193-A-1 9.26 RAF1
9 Decreased substrate adherent cell growth GR00193-A-2 9.26 ALK RAF1 TGFBR1

MGI Mouse Phenotypes related to Acantholytic Acanthoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.09 ALK ATP2A2 CCDC39 DLG4 NF1 RAF1
2 cellular MP:0005384 10.06 ATP2A2 CCDC39 MME NF1 RAF1 TGFBR1
3 cardiovascular system MP:0005385 10.02 ATP2A2 CCDC39 NF1 RAF1 TGFBR1 TGFBR3
4 immune system MP:0005387 10.01 ATP2A2 CCDC39 DLG4 MME NF1 RAF1
5 mortality/aging MP:0010768 9.97 ALK ATP2A2 CCDC39 DLG4 NF1 RAF1
6 integument MP:0010771 9.91 ALK ATP2A2 DLG4 MME NF1 RAF1
7 nervous system MP:0003631 9.81 ALK ATP2A2 CCDC39 DLG4 MME NF1
8 neoplasm MP:0002006 9.65 ALK ATP2A2 NF1 RAF1 TGFBR1
9 respiratory system MP:0005388 9.43 ALK ATP2A2 CCDC39 NF1 RAF1 TGFBR1
10 skeleton MP:0005390 9.23 ALK ATP2A2 CCDC39 DLG4 NF1 RAF1

Drugs & Therapeutics for Acantholytic Acanthoma

Search Clinical Trials , NIH Clinical Center for Acantholytic Acanthoma

Genetic Tests for Acantholytic Acanthoma

Anatomical Context for Acantholytic Acanthoma

MalaCards organs/tissues related to Acantholytic Acanthoma:

40
Skin

Publications for Acantholytic Acanthoma

Articles related to Acantholytic Acanthoma:

(show all 11)
# Title Authors PMID Year
1
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. 61
25186214 2016
2
Acantholysis caused repeated hemorrhagic bullae in a case of acantholytic acanthoma. 61
22568826 2012
3
Acantholytic dyskeratotic acanthoma: a variant of a benign keratosis. 61
18251744 2008
4
Acantholytic acanthoma clinically resembling a molluscum contagiosum. 61
17207187 2007
5
Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. 61
17214854 2007
6
Multiple spreading epidermolytic acanthomas of the genital and perigenital skin. 61
16088164 2005
7
Acantholytic acanthoma. 61
10721663 2000
8
A solitary, erythematous, hyperkeratotic papule. Acantholytic acanthoma. 61
7857120 1995
9
Acantholytic acanthoma. 61
8517501 1993
10
Acantholytic acanthoma. 61
2461398 1988
11
The benign acanthomas. 61
3160731 1985

Variations for Acantholytic Acanthoma

Expression for Acantholytic Acanthoma

Search GEO for disease gene expression data for Acantholytic Acanthoma.

Pathways for Acantholytic Acanthoma

Pathways related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.98 TGFBR3 TGFBR1 RAF1 ATP2A2 ALK
2
Show member pathways
12.6 TJP1 TGFBR3 TGFBR1 RAF1
3 11.99 RAF1 ATP2A2 ATP1B4
4
Show member pathways
11.75 TGFBR3 TGFBR1 RAF1
5 11.56 TGFBR3 TGFBR1 RAF1
6 11.41 RAF1 ATP2A2 ATP1B4
7
Show member pathways
11.17 RAF1 NF1
8 11.11 TGFBR3 TGFBR1 RAF1
9 11.1 RAF1 ALK
10 10.99 RAF1 ATP2A2
11 10.8 TGFBR3 TGFBR1
12 10.55 TGFBR3 TGFBR1
13 10.28 TGFBR3 TGFBR1 RAF1

GO Terms for Acantholytic Acanthoma

Cellular components related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 9.65 TJP1 TGFBR1 RAF1 DLG4 ATP2A2
2 receptor complex GO:0043235 9.5 TGFBR3 TGFBR1 ALK
3 membrane GO:0016020 9.36 TJP1 TGFBR3 TGFBR1 RAF1 PVR NF1
4 presynapse GO:0098793 9.33 NF1 MME DLG4
5 neuron projection terminus GO:0044306 8.96 MME DLG4

Biological processes related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to hypoxia GO:0001666 9.63 TGFBR3 RAF1 NF1
2 ventricular septum morphogenesis GO:0060412 9.48 TGFBR3 TGFBR1
3 artery morphogenesis GO:0048844 9.43 TGFBR1 NF1
4 regulation of protein binding GO:0043393 9.4 TGFBR3 TGFBR1
5 regulation of long-term neuronal synaptic plasticity GO:0048169 9.37 NF1 DLG4
6 wound healing GO:0042060 9.33 TGFBR1 RAF1 NF1
7 pathway-restricted SMAD protein phosphorylation GO:0060389 9.32 TGFBR3 TGFBR1
8 cardiac epithelial to mesenchymal transition GO:0060317 9.26 TGFBR3 TGFBR1
9 ventricular compact myocardium morphogenesis GO:0003223 8.96 TGFBR3 TGFBR1
10 heart development GO:0007507 8.92 TGFBR1 RAF1 NF1 CCDC39

Molecular functions related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transforming growth factor beta binding GO:0050431 9.26 TGFBR3 TGFBR1
2 activin binding GO:0048185 9.16 TGFBR3 TGFBR1
3 transforming growth factor beta-activated receptor activity GO:0005024 8.96 TGFBR3 TGFBR1
4 type II transforming growth factor beta receptor binding GO:0005114 8.62 TGFBR3 TGFBR1

Sources for Acantholytic Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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