MCID: ACN004
MIFTS: 26

Acantholytic Acanthoma

Categories: Cancer diseases

Aliases & Classifications for Acantholytic Acanthoma

MalaCards integrated aliases for Acantholytic Acanthoma:

Name: Acantholytic Acanthoma 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:4324
NCIt 49 C27517
UMLS 71 C1301270

Summaries for Acantholytic Acanthoma

MalaCards based summary : Acantholytic Acanthoma is related to pemphigus vegetans and pemphigus vulgaris, familial. An important gene associated with Acantholytic Acanthoma is CCDC39 (Coiled-Coil Domain Containing 39), and among its related pathways/superpathways are Keratinization and Integrated Breast Cancer Pathway. Affiliated tissues include skin, and related phenotypes are growth/size/body region and cellular

Related Diseases for Acantholytic Acanthoma

Diseases related to Acantholytic Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 pemphigus vegetans 30.8 DSG1 DSC3
2 pemphigus vulgaris, familial 30.4 DSG3 DSG1 DSC3
3 benign chronic pemphigus 29.6 DSG3 DSG1 DSC3 DSC2 ATP2C1 ATP2A2
4 pemphigus 29.6 DSG3 DSG1 DSC3 DSC2 ATP2C1 ANXA9
5 clear cell acanthoma 10.6
6 acanthoma 10.6
7 epidermolytic hyperkeratosis 10.3
8 keratosis 10.3
9 papilloma 10.3
10 lung clear cell carcinoma 10.3 DSC3 DSC2
11 arrhythmogenic right ventricular dysplasia, familial, 11 10.3 DSC3 DSC2
12 arrhythmogenic right ventricular dysplasia, familial, 10 10.3 DSC3 DSC2
13 arrhythmogenic right ventricular dysplasia, familial, 8 10.3 DSC3 DSC2
14 herpetiform pemphigus 10.3 DSG3 DSG1
15 adenoid squamous cell carcinoma 10.3 DSG3 DSC2
16 bullous impetigo 10.3 DSG3 DSG1
17 arrhythmogenic right ventricular dysplasia, familial, 5 10.2 DSC3 DSC2
18 pemphigus gestationis 10.2 DSG3 DSG1
19 arrhythmogenic right ventricular dysplasia, familial, 12 10.2 DSC3 DSC2
20 epidermolytic acanthoma 10.2
21 bullous pemphigoid 10.2
22 molluscum contagiosum 10.2
23 lichen planus 10.2
24 autosomal dominant epidermolytic ichthyosis 10.2
25 superficial pemphigus 10.2
26 pemphigus foliaceus 10.2 DSG3 DSG1
27 pemphigoid gestationis 10.2 DSG3 DSG1
28 cardiomyopathy, dilated, with woolly hair and keratoderma 10.2 DSC3 DSC2
29 viral esophagitis 10.1 DSG3 DSG1
30 arrhythmogenic right ventricular dysplasia, familial, 9 10.1 DSC3 DSC2
31 iga pemphigus 10.1 DSG3 DSG1 DSC3
32 hidradenitis 10.1 DSG3 DSG1 DSC2
33 hidradenitis suppurativa 10.1 DSG3 DSG1 DSC2
34 subcorneal pustular dermatosis 10.1 DSG3 DSG1 DSC3
35 dystonia 3, torsion, x-linked 10.0 DSC3 DSC2
36 paraneoplastic pemphigus 9.9 DSG3 DSG1 DSC3 DSC2
37 maxillary sinus adenocarcinoma 9.9 FASLG ATM
38 palmoplantar keratosis 9.9 DSG3 DSG1 DSC3 DSC2
39 skin papilloma 9.8 PVR CCDC39
40 darier-white disease 9.8 DSG3 DSC3 DSC2 ATP2C1 ATP2A2
41 impetigo 9.8 DSG3 DSG1 DSC3 CDH17
42 ritter's disease 9.6 DSG3 DSG1 DSC3 DSC2 CDH17
43 cellulitis 9.4 DSG3 DSG1 DSC3 DSC2 CDH17 ATP2C1
44 bullous skin disease 9.2 DSG3 DSG1 DSC3 DSC2 CDH17 ATP2C1
45 skin disease 9.1 DSG3 DSG1 DSC3 CASP8 ATP2C1 ATP2A2
46 gastric adenocarcinoma 8.7 TJP1 FASLG CDH17 CASP8 ATM

Graphical network of the top 20 diseases related to Acantholytic Acanthoma:



Diseases related to Acantholytic Acanthoma

Symptoms & Phenotypes for Acantholytic Acanthoma

MGI Mouse Phenotypes related to Acantholytic Acanthoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.14 ATM ATP2A2 ATP2C1 CASP8 CCDC39 DLG4
2 cellular MP:0005384 10.13 ATM ATP2A2 ATP2C1 CASP8 CCDC39 DSC3
3 hematopoietic system MP:0005397 10.11 ANXA9 ATM ATP2A2 CASP8 CCDC39 CDH17
4 immune system MP:0005387 10.06 ANXA9 ATM ATP2A2 CASP8 CCDC39 CDH17
5 integument MP:0010771 9.96 ATM ATP2A2 ATP2C1 CASP8 DLG4 DSC3
6 nervous system MP:0003631 9.7 ATM ATP2A2 ATP2C1 CASP8 CCDC39 DLG4
7 neoplasm MP:0002006 9.63 ATM ATP2A2 ATP2C1 CASP8 FASLG NF1
8 skeleton MP:0005390 9.23 ANXA9 ATP2A2 CCDC39 DLG4 DSG1 DSG3

Drugs & Therapeutics for Acantholytic Acanthoma

Search Clinical Trials , NIH Clinical Center for Acantholytic Acanthoma

Genetic Tests for Acantholytic Acanthoma

Anatomical Context for Acantholytic Acanthoma

MalaCards organs/tissues related to Acantholytic Acanthoma:

40
Skin

Publications for Acantholytic Acanthoma

Articles related to Acantholytic Acanthoma:

(show all 11)
# Title Authors PMID Year
1
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. 61
25186214 2016
2
Acantholysis caused repeated hemorrhagic bullae in a case of acantholytic acanthoma. 61
22568826 2012
3
Acantholytic dyskeratotic acanthoma: a variant of a benign keratosis. 61
18251744 2008
4
Acantholytic acanthoma clinically resembling a molluscum contagiosum. 61
17207187 2007
5
Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. 61
17214854 2007
6
Multiple spreading epidermolytic acanthomas of the genital and perigenital skin. 61
16088164 2005
7
Acantholytic acanthoma. 61
10721663 2000
8
A solitary, erythematous, hyperkeratotic papule. Acantholytic acanthoma. 61
7857120 1995
9
Acantholytic acanthoma. 61
8517501 1993
10
Acantholytic acanthoma. 61
2461398 1988
11
The benign acanthomas. 61
3160731 1985

Variations for Acantholytic Acanthoma

Expression for Acantholytic Acanthoma

Search GEO for disease gene expression data for Acantholytic Acanthoma.

Pathways for Acantholytic Acanthoma

Pathways related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.01 DSG3 DSG1 DSC3 DSC2
2 11.69 NF1 CASP8 ATM
3 11.35 TJP1 SIRPA PVR CDH17
4 11.2 FASLG CASP8 ATM
5
Show member pathways
10.99 TJP1 DSG3 DSG1 CASP8

GO Terms for Acantholytic Acanthoma

Cellular components related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.14 TJP1 SIRPA PVR FASLG DSG3 DSG1
2 cell GO:0005623 9.91 FASLG DLG4 ATP2C1 ATP2A2 ATM ANXA9
3 cell junction GO:0030054 9.87 TJP1 DSG3 DSG1 DSC3 DSC2 DLG4
4 cell surface GO:0009986 9.77 SIRPA PVR FASLG CDH17 ANXA9
5 cell-cell adherens junction GO:0005913 9.56 TJP1 PVR DSC2 CDH17
6 cell-cell junction GO:0005911 9.55 TJP1 DSG3 DSG1 DSC3 DSC2
7 cornified envelope GO:0001533 9.26 DSG3 DSG1 DSC3 DSC2
8 desmosome GO:0030057 8.92 DSG3 DSG1 DSC3 DSC2

Biological processes related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.78 DSG3 DSG1 DSC3 DSC2
2 cell adhesion GO:0007155 9.76 SIRPA PVR DSG3 DSG1 DSC3 DSC2
3 response to lipopolysaccharide GO:0032496 9.73 TJP1 FASLG CASP8 ATP2A2
4 calcium ion transmembrane transport GO:0070588 9.7 ATP2C1 ATP2A2 ANXA9
5 positive regulation of neuron apoptotic process GO:0043525 9.63 NF1 FASLG ATM
6 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules GO:0016339 9.58 DSG1 CDH17 ATP2C1
7 cornification GO:0070268 9.56 DSG3 DSG1 DSC3 DSC2
8 cell-cell junction assembly GO:0007043 9.54 TJP1 DSG1 CDH17
9 regulation of long-term neuronal synaptic plasticity GO:0048169 9.51 NF1 DLG4
10 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.5 NF1 FASLG CASP8
11 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.49 FASLG CASP8
12 homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 9.43 PVR DSG3 DSG1 DSC3 DSC2 CDH17
13 cell-cell adhesion GO:0098609 9.23 SIRPA DSG3 DSG1 DSC3 DSC2 DLG4

Molecular functions related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 S100 protein binding GO:0044548 9.37 ATP2A2 ANXA9
2 proton-exporting ATPase activity, phosphorylative mechanism GO:0008553 9.32 ATP2C1 ATP2A2
3 death receptor binding GO:0005123 9.26 FASLG CASP8
4 calcium ion binding GO:0005509 9.17 DSG3 DSG1 DSC3 DSC2 CDH17 ATP2A2
5 gamma-catenin binding GO:0045295 9.16 DSG1 DSC3
6 calcium-transporting ATPase activity GO:0005388 8.96 ATP2C1 ATP2A2

Sources for Acantholytic Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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