MCID: ACN004
MIFTS: 28

Acantholytic Acanthoma

Categories: Cancer diseases

Aliases & Classifications for Acantholytic Acanthoma

MalaCards integrated aliases for Acantholytic Acanthoma:

Name: Acantholytic Acanthoma 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4324
NCIt 50 C27517
SNOMED-CT 67 397188008
UMLS 70 C1301270

Summaries for Acantholytic Acanthoma

MalaCards based summary : Acantholytic Acanthoma is related to clear cell acanthoma and acanthoma. An important gene associated with Acantholytic Acanthoma is CCDC39 (Coiled-Coil Domain Containing 39), and among its related pathways/superpathways are p70S6K Signaling and NFAT and Cardiac Hypertrophy. Affiliated tissues include skin, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Acantholytic Acanthoma

Diseases related to Acantholytic Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 10.5
2 acanthoma 10.5
3 epidermolytic hyperkeratosis 10.2
4 keratosis 10.2
5 papilloma 10.2
6 cervix erosion 10.2 MME KRT5
7 subareolar duct papillomatosis 10.2 MME KRT5
8 nipple benign neoplasm 10.2 MME KRT5
9 micronodular basal cell carcinoma 10.2 MME KRT5
10 sarcomatoid squamous cell skin carcinoma 10.2 MME KRT5
11 breast metaplastic carcinoma 10.2 MME KRT5
12 balloon cell malignant melanoma 10.2 MME KRT5
13 clear cell hidradenoma 10.2 MME KRT5
14 hidradenoma 10.2 MME KRT5
15 nephrogenic adenoma of the urethra 10.2 MME KRT5
16 cystadenofibroma 10.2 MME KRT5
17 breast sarcoma 10.1 MME KRT5
18 breast malignant phyllodes tumor 10.1 MME KRT5
19 cutaneous adenocystic carcinoma 10.1 MME KRT5
20 heart lymphoma 10.1 MME ALK
21 inflammatory liposarcoma 10.1 MME ALK
22 bone lymphoma 10.1 MME ALK
23 nasal cavity olfactory neuroblastoma 10.1 MME KRT5
24 breast lymphoma 10.1 MME ALK
25 breast osteosarcoma 10.1 MME KRT5
26 urethral benign neoplasm 10.1 MME KRT5
27 epididymis adenocarcinoma 10.1 MME KRT5
28 epididymis cancer 10.1 MME KRT5
29 pediatric lymphoma 10.1 MME ALK
30 intraductal breast benign neoplasm 10.1 MME KRT5
31 breast benign neoplasm 10.1 MME KRT5
32 adult lymphoma 10.1 MME ALK
33 central epithelioid sarcoma 10.1 MME KRT5
34 vulvar proximal-type epithelioid sarcoma 10.1 MME KRT5
35 pilar sheath acanthoma 10.1 MME KRT5
36 benign chronic pemphigus 10.1
37 pemphigus vulgaris, familial 10.1
38 epidermolytic acanthoma 10.1
39 molluscum contagiosum 10.1
40 pemphigus 10.1
41 lichen planus 10.1
42 autosomal dominant epidermolytic ichthyosis 10.1
43 superficial pemphigus 10.1
44 pemphigus vegetans 10.1
45 sweat gland benign neoplasm 10.1 MME KRT5
46 pacinian tumor 10.0 NF1 MME
47 epididymal neoplasm 10.0 NF1 MME
48 urethra clear cell adenocarcinoma 10.0 KRT5 ALK
49 thoracic benign neoplasm 9.9 MME KRT5
50 pulsating exophthalmos 9.9 TGFBR1 NF1

Graphical network of the top 20 diseases related to Acantholytic Acanthoma:



Diseases related to Acantholytic Acanthoma

Symptoms & Phenotypes for Acantholytic Acanthoma

GenomeRNAi Phenotypes related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.88 MAPK8 NF1 RAF1 ALK TGFBR1
2 Decreased viability GR00221-A-2 9.88 DLG4 MAPK8 NF1 RAF1
3 Decreased viability GR00221-A-4 9.88 NF1 ALK TGFBR1
4 Decreased viability GR00249-S 9.88 NF1 ALK TGFBR1
5 Decreased viability GR00301-A 9.88 RAF1
6 Decreased viability GR00342-S-2 9.88 MAPK8
7 Decreased viability GR00342-S-3 9.88 MAPK8
8 Decreased viability GR00386-A-1 9.88 NF1
9 Decreased viability GR00402-S-2 9.88 MAPK8 RAF1 TGFBR1
10 Decreased substrate adherent cell growth GR00193-A-1 9.26 RAF1
11 Decreased substrate adherent cell growth GR00193-A-2 9.26 ALK RAF1 TGFBR1

MGI Mouse Phenotypes related to Acantholytic Acanthoma:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.2 ATP2A2 CCDC39 MAPK8 MME NF1 RAF1
2 cellular MP:0005384 10.19 ATP2A2 CCDC39 MAPK8 MME NF1 RAF1
3 growth/size/body region MP:0005378 10.18 ALK ATP2A2 CCDC39 DLG4 KRT5 MAPK8
4 immune system MP:0005387 10.11 ATP2A2 CCDC39 KRT5 MAPK8 MME NF1
5 mortality/aging MP:0010768 10.11 ALK ATP2A2 CCDC39 DLG4 KRT5 MAPK8
6 integument MP:0010771 10.09 ALK ATP2A2 DLG4 KRT5 MAPK8 MME
7 embryo MP:0005380 10.04 ATP2A2 MAPK8 NF1 RAF1 TGFBR1 TGFBR3
8 craniofacial MP:0005382 10 CCDC39 KRT5 MAPK8 NF1 RAF1 TGFBR3
9 digestive/alimentary MP:0005381 9.99 ATP2A2 CCDC39 KRT5 MAPK8 NF1 TGFBR1
10 nervous system MP:0003631 9.9 ALK ATP2A2 CCDC39 DLG4 MAPK8 MME
11 liver/biliary system MP:0005370 9.88 CCDC39 MAPK8 MME NF1 RAF1 TGFBR3
12 muscle MP:0005369 9.8 ATP2A2 MAPK8 NF1 RAF1 TGFBR1 TGFBR3
13 neoplasm MP:0002006 9.73 ALK ATP2A2 MAPK8 NF1 RAF1 TGFBR1
14 respiratory system MP:0005388 9.5 ALK ATP2A2 CCDC39 MAPK8 NF1 RAF1
15 skeleton MP:0005390 9.23 ALK ATP2A2 CCDC39 DLG4 NF1 RAF1

Drugs & Therapeutics for Acantholytic Acanthoma

Search Clinical Trials , NIH Clinical Center for Acantholytic Acanthoma

Genetic Tests for Acantholytic Acanthoma

Anatomical Context for Acantholytic Acanthoma

MalaCards organs/tissues related to Acantholytic Acanthoma:

40
Skin

Publications for Acantholytic Acanthoma

Articles related to Acantholytic Acanthoma:

(show all 12)
# Title Authors PMID Year
1
[A case of nasal vestibule acantholytic acanthoma]. 61
33254352 2020
2
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. 61
25186214 2016
3
Acantholysis caused repeated hemorrhagic bullae in a case of acantholytic acanthoma. 61
22568826 2012
4
Acantholytic dyskeratotic acanthoma: a variant of a benign keratosis. 61
18251744 2008
5
Changes of epidermodysplasia verruciformis in benign skin lesions: the EV acanthoma. 61
17214854 2007
6
Acantholytic acanthoma clinically resembling a molluscum contagiosum. 61
17207187 2007
7
Multiple spreading epidermolytic acanthomas of the genital and perigenital skin. 61
16088164 2005
8
Acantholytic acanthoma. 61
10721663 2000
9
A solitary, erythematous, hyperkeratotic papule. Acantholytic acanthoma. 61
7857120 1995
10
Acantholytic acanthoma. 61
8517501 1993
11
Acantholytic acanthoma. 61
2461398 1988
12
The benign acanthomas. 61
3160731 1985

Variations for Acantholytic Acanthoma

Expression for Acantholytic Acanthoma

Search GEO for disease gene expression data for Acantholytic Acanthoma.

Pathways for Acantholytic Acanthoma

Pathways related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.68 TGFBR3 TGFBR1 RAF1 MAPK8 ALK
2
Show member pathways
12.62 TGFBR3 TGFBR1 RAF1 MAPK8
3 12.58 TGFBR1 RAF1 MAPK8 ALK
4
Show member pathways
12.56 TJP1 TGFBR3 TGFBR1 RAF1 MAPK8
5 12.49 TGFBR1 RAF1 NF1 MAPK8
6
Show member pathways
12.38 RAF1 NF1 MAPK8 ALK
7
Show member pathways
11.91 TGFBR1 RAF1 MAPK8
8
Show member pathways
11.83 TGFBR3 TGFBR1 RAF1 MAPK8
9
Show member pathways
11.82 TGFBR1 RAF1 MAPK8
10 11.66 RAF1 NF1 MAPK8
11 11.58 TGFBR3 TGFBR1 RAF1 MAPK8
12
Show member pathways
11.32 TGFBR1 RAF1 MAPK8
13
Show member pathways
11.31 RAF1 NF1
14 11.13 RAF1 ATP2A2
15 11.11 NF1 MAPK8
16 11.01 RAF1 MAPK8
17 10.96 TJP1 MAPK8
18 10.91 TGFBR3 TGFBR1 RAF1
19 10.91 TGFBR3 TGFBR1 RAF1 MAPK8
20 10.73 TGFBR3 TGFBR1
21 10.53 TGFBR3 TGFBR1 MAPK8

GO Terms for Acantholytic Acanthoma

Cellular components related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.43 TGFBR3 TGFBR1 ALK
2 presynapse GO:0098793 9.33 NF1 MME DLG4
3 neuron projection terminus GO:0044306 8.96 MME DLG4
4 axon GO:0030424 8.92 NF1 MME MAPK8 DLG4

Biological processes related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.8 TJP1 TGFBR1 RAF1 MAPK8
2 intracellular signal transduction GO:0035556 9.71 TGFBR3 TGFBR1 RAF1 MAPK8
3 response to hypoxia GO:0001666 9.65 TGFBR3 RAF1 NF1
4 ventricular septum morphogenesis GO:0060412 9.51 TGFBR3 TGFBR1
5 artery morphogenesis GO:0048844 9.46 TGFBR1 NF1
6 MAPK cascade GO:0000165 9.46 RAF1 NF1 MAPK8 DLG4
7 regulation of protein binding GO:0043393 9.43 TGFBR3 TGFBR1
8 wound healing GO:0042060 9.43 TGFBR1 RAF1 NF1
9 pathway-restricted SMAD protein phosphorylation GO:0060389 9.37 TGFBR3 TGFBR1
10 cardiac epithelial to mesenchymal transition GO:0060317 9.32 TGFBR3 TGFBR1
11 ventricular compact myocardium morphogenesis GO:0003223 8.96 TGFBR3 TGFBR1
12 heart development GO:0007507 8.92 TGFBR1 RAF1 NF1 CCDC39

Molecular functions related to Acantholytic Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.62 TGFBR1 RAF1 MAPK8 ALK
2 protein C-terminus binding GO:0008022 9.54 TJP1 DLG4 ATP2A2
3 transforming growth factor beta binding GO:0050431 9.26 TGFBR3 TGFBR1
4 activin binding GO:0048185 9.16 TGFBR3 TGFBR1
5 transforming growth factor beta-activated receptor activity GO:0005024 8.96 TGFBR3 TGFBR1
6 type II transforming growth factor beta receptor binding GO:0005114 8.62 TGFBR3 TGFBR1

Sources for Acantholytic Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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