MCID: ACN010
MIFTS: 34

Acanthoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Acanthoma

MalaCards integrated aliases for Acanthoma:

Name: Acanthoma 12 53 15 73

Classifications:



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Disease Ontology 12 DOID:174
MeSH 44 D049309
NCIt 50 C7419
UMLS 73 C0846967

Summaries for Acanthoma

NIH Rare Diseases : 53 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  There are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  Though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  The exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  Acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms.

MalaCards based summary : Acanthoma is related to clear cell acanthoma and large cell acanthoma. An important gene associated with Acanthoma is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, ovary and testes, and related phenotype is pigmentation.

Wikipedia : 76 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 34.0 FGF10 FGFR2
2 large cell acanthoma 33.7 KRT10 KRT17
3 epidermolytic acanthoma 33.6 KRT1 KRT10
4 keratosis 30.4 KRT1 KRT10
5 bowen's disease 30.1 KRT10 KRT17
6 keratoacanthoma 29.8 KRT10 KRT17
7 pilar sheath acanthoma 12.3
8 acantholytic acanthoma 12.2
9 onychocytic matricoma 11.2
10 psoriasis 10.2
11 nevus, epidermal 10.1
12 squamous cell carcinoma 10.1
13 apert syndrome 10.1 FGF10 FGFR2
14 basal cell carcinoma, infundibulocystic 10.0 KRT10 KRT17
15 muir-torre syndrome 10.0
16 epidermodysplasia verruciformis 10.0
17 ichthyosis 10.0
18 melanoma 10.0
19 eccrine acrospiroma 10.0 KRT10 KRT17
20 steatocystoma multiplex 10.0 KRT10 KRT17
21 muenke syndrome 10.0 FGF10 FGFR2
22 eccrine sweat gland neoplasm 10.0 KRT10 KRT17
23 lacrimoauriculodentodigital syndrome 10.0 FGF10 FGFR2
24 keratosis, seborrheic 10.0 KRT10 KRT17
25 pachyonychia congenita 1 10.0 KRT10 KRT17
26 primary cutaneous amyloidosis 10.0 KRT10 KRT17
27 cholesteatoma of middle ear 9.9 FGFR2 KRT10
28 erythroderma, ichthyosiform, congenital reticular 9.9 KRT1 KRT10
29 pfeiffer syndrome 9.9 FGF10 FGFR2
30 ichthyosis, cyclic, with epidermolytic hyperkeratosis 9.9 KRT1 KRT10
31 ichthyosis bullosa of siemens 9.9 KRT1 KRT10
32 striate palmoplantar keratoderma 9.9 KRT1 KRT10
33 filamentary keratitis 9.9 KRT1 KRT10
34 autosomal dominant epidermolytic ichthyosis 9.9 KRT1 KRT10
35 white sponge nevus 1 9.9 KRT1 KRT10
36 psoriasis 2 9.9
37 basal cell carcinoma 1 9.9
38 psoriasis 7 9.9
39 psoriasis 11 9.9
40 psoriasis 13 9.9
41 autosomal recessive congenital ichthyosis 9.9
42 basal cell carcinoma 9.9
43 papilloma 9.9
44 endometriosis 9.9
45 porokeratosis 9.9
46 cowden disease 9.9
47 inverted follicular keratosis 9.9
48 bullous pemphigoid 9.9
49 in situ carcinoma 9.9
50 molluscum contagiosum 9.9

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma

Symptoms & Phenotypes for Acanthoma

MGI Mouse Phenotypes related to Acanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 FGFR2 KRT1 KRT17

Drugs & Therapeutics for Acanthoma

Search Clinical Trials , NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

MalaCards organs/tissues related to Acanthoma:

41
Skin, Ovary, Testes, Uterus

Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 233)
# Title Authors Year
1
Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia. ( 29735169 )
2018
2
Two cases of large cell acanthoma successfully treated with photodynamic therapy. ( 29633447 )
2018
3
Multiple Eruptive Clear Cell Acanthoma. ( 29692468 )
2018
4
Longitudinal subungual acanthoma: one denomination for various clinical presentations. ( 29705997 )
2018
5
Dermoscopic features of clear cell acanthoma. ( 29924237 )
2018
6
Giant clear cell acanthoma with dermatoscopic white lines. ( 30116672 )
2018
7
Clear Cell Acanthoma on the Areola. ( 30261576 )
2018
8
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. ( 29267438 )
2017
9
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. ( 28857272 )
2017
10
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. ( 28426905 )
2017
11
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. ( 28868008 )
2017
12
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. ( 29085717 )
2017
13
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2017
14
Reticulated acanthoma with sebaceous differentiation. ( 28492170 )
2017
15
Acanthoma Fissuratum: Lest we Forget. ( 28405560 )
2017
16
"String of pearls pattern": report of three cases of non clear-cell acanthoma. ( 29267474 )
2017
17
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. ( 28470879 )
2017
18
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. ( 28609346 )
2017
19
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. ( 26825163 )
2016
20
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 27814733 )
2016
21
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
22
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
23
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
24
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
25
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. ( 26945829 )
2016
26
Porokeratotic acanthoma. ( 25631132 )
2015
27
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
28
Pilar Sheath Acanthoma Presenting as a Nevus. ( 26903752 )
2015
29
An Unusual Location of a Pilar Sheath Acanthoma. ( 26903749 )
2015
30
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? ( 26512188 )
2015
31
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2015
32
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2014
33
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2014
34
An unusual location of a pilar sheath acanthoma. ( 25368479 )
2014
35
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
36
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. ( 25184922 )
2014
37
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. ( 25607402 )
2014
38
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. ( 25151914 )
2014
39
Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 24890648 )
2014
40
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
41
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. ( 25186214 )
2014
42
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. ( 25267214 )
2014
43
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2014
44
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2014
45
Pilar sheath acanthoma simulating basal cell carcinoma. ( 24566580 )
2014
46
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
47
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
48
Acantholytic dyskeratotic acanthoma: case report and review of the literature. ( 25126453 )
2014
49
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. ( 23083445 )
2013
50
A shiny red papule in an older person. Clear cell acanthoma. ( 23944729 )
2013

Variations for Acanthoma

Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 FGF10 FGFR2 KRT1 KRT10 KRT17
2
Show member pathways
11.59 KRT1 KRT10 KRT17
3
Show member pathways
11.19 KRT1 KRT17

GO Terms for Acanthoma

Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 9.16 KRT1 KRT10
2 extracellular matrix GO:0031012 9.13 FGF10 FGFR2 KRT1
3 intermediate filament GO:0005882 8.8 KRT1 KRT10 KRT17

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.73 KRT1 KRT10 KRT17
2 cornification GO:0070268 9.67 KRT1 KRT10 KRT17
3 epidermis development GO:0008544 9.65 FGF10 KRT17
4 wound healing GO:0042060 9.65 FGF10 FGFR2
5 lung development GO:0030324 9.65 FGF10 FGFR2
6 positive regulation of canonical Wnt signaling pathway GO:0090263 9.64 FGF10 FGFR2
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.64 FGF10 FGFR2
8 epithelial cell differentiation GO:0030855 9.63 FGF10 FGFR2
9 inner ear morphogenesis GO:0042472 9.63 FGF10 FGFR2
10 positive regulation of epithelial cell proliferation GO:0050679 9.62 FGF10 FGFR2
11 peptide cross-linking GO:0018149 9.62 KRT1 KRT10
12 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.61 FGF10 FGFR2
13 protein heterotetramerization GO:0051290 9.61 KRT1 KRT10
14 positive regulation of Wnt signaling pathway GO:0030177 9.6 FGF10 FGFR2
15 lung alveolus development GO:0048286 9.59 FGF10 FGFR2
16 digestive tract development GO:0048565 9.58 FGF10 FGFR2
17 regulation of smoothened signaling pathway GO:0008589 9.58 FGF10 FGFR2
18 embryonic pattern specification GO:0009880 9.57 FGF10 FGFR2
19 embryonic digestive tract morphogenesis GO:0048557 9.55 FGF10 FGFR2
20 branching involved in salivary gland morphogenesis GO:0060445 9.54 FGF10 FGFR2
21 organ growth GO:0035265 9.52 FGF10 FGFR2
22 limb bud formation GO:0060174 9.51 FGF10 FGFR2
23 bud elongation involved in lung branching GO:0060449 9.48 FGF10 FGFR2
24 lacrimal gland development GO:0032808 9.46 FGF10 FGFR2
25 otic vesicle formation GO:0030916 9.43 FGF10 FGFR2
26 epidermis morphogenesis GO:0048730 9.4 FGF10 FGFR2
27 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.37 FGF10 FGFR2
28 branch elongation involved in salivary gland morphogenesis GO:0060667 9.32 FGF10 FGFR2
29 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.26 FGF10 FGFR2
30 mammary gland bud formation GO:0060615 9.16 FGF10 FGFR2
31 mesenchymal cell differentiation involved in lung development GO:0060915 8.96 FGF10 FGFR2
32 hair follicle morphogenesis GO:0031069 8.8 FGF10 FGFR2 KRT17

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.26 FGF10 FGFR2
2 1-phosphatidylinositol-3-kinase activity GO:0016303 9.16 FGF10 FGFR2
3 structural molecule activity GO:0005198 9.13 KRT1 KRT10 KRT17
4 structural constituent of epidermis GO:0030280 8.62 KRT1 KRT10

Sources for Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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