MCID: ACN010
MIFTS: 39

Acanthoma

Categories: Cancer diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Acanthoma

MalaCards integrated aliases for Acanthoma:

Name: Acanthoma 11 19 14 71 75

Classifications:



External Ids:

Disease Ontology 11 DOID:174
MeSH 43 D049309
NCIt 49 C7419
UMLS 71 C0846967

Summaries for Acanthoma

GARD: 19 "An Acanthoma is a small, reddish bump that usually develops on the skin of an older adult. There are several types of Acanthoma, including ""acantholytic"", ""epidermolytic"", ""clear cell"", and ""melanoAcanthoma"". Though most individuals have only one Acanthoma, some people may develop many. The exact cause of Acanthoma is not known."

MalaCards based summary: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT10 (Keratin 10), and among its related pathways/superpathways are PIP3 activates AKT signaling and Downstream signaling of activated FGFR2. Affiliated tissues include skin, uterus and cervix, and related phenotypes are growth/size/body region and nervous system

Wikipedia: 75 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 32.9 KRT5 KRT10
2 epidermolytic acanthoma 32.6 KRT10 KRT1
3 large cell acanthoma 31.5 TP53 MLANA KRT5 KRT10 CD1B
4 autosomal dominant epidermolytic ichthyosis 31.2 KRT10 KRT1
5 epidermolytic hyperkeratosis 30.8 KRT5 KRT10 KRT1
6 muir-torre syndrome 30.5 TP53 KRT5 CDKN2A
7 keratoacanthoma 30.5 TP53 PIK3CA KRT10
8 lichen planus 30.3 TP53 KRT10 KRT1
9 anogenital venereal wart 30.3 TP53 TMC8 CDKN2A
10 ichthyosis bullosa of siemens 30.2 KRT10 KRT1
11 actinic keratosis 30.1 TP53 TMC8 MLANA KRT10 CDKN2A
12 nevus, epidermal 30.1 PIK3CA KRT10 KRT1 FGFR3 FGFR2
13 eccrine acrospiroma 30.1 KRT5 KRT10
14 keratosis 30.0 TP53 TMC8 PIK3CA KRT5 KRT10 KRT1
15 papilloma 30.0 TP53 KRT5 KRT10 KRT1 FGFR3 CDKN2A
16 epidermodysplasia verruciformis 1 29.9 TP53 TMC8 TMC6 CDKN2A
17 porokeratosis 29.9 TP53 TMC8 KRT10 KRT1 FGFR3 FGFR2
18 anus cancer 29.9 TP53 PIK3CA CDKN2A
19 squamous cell carcinoma 29.8 TP53 PIK3CA FGFR3 FGFR2 CDKN2A
20 common wart 29.8 TP53 TMC8 TMC6
21 skin squamous cell carcinoma 29.7 TP53 KRT5 KRT10 CDKN2A
22 basal cell carcinoma 29.5 TYR TP53 KRT5 KRT10 KRT1 CDKN2A
23 melanoma in congenital melanocytic nevus 29.3 TYR TP53 MLANA CDKN2A
24 skin benign neoplasm 29.1 TYR TP53 MLANA KRT5 KRT1 FGFR3
25 skin carcinoma 28.9 TYR TP53 TMC8 TMC6 MLANA KRT5
26 skin disease 28.0 TYR TP53 PIK3CA MLANA KRT5 KRT10
27 keratosis, seborrheic 27.3 TYR TP53 TMC8 TMC6 PIK3CA MLANA
28 pilar sheath acanthoma 11.5
29 acantholytic acanthoma 11.2
30 onychocytic matricoma 11.1
31 erythrokeratoderma ''en cocardes'' 10.4
32 hemifacial hyperplasia 10.4 FGFR3 FGFR2
33 plagiocephaly 10.4 FGFR3 FGFR2
34 posttransplant acute limbic encephalitis 10.3
35 testicular spermatocytic seminoma 10.3 FGFR3 FGFR2
36 ichthyosis with confetti 10.3 KRT10 KRT1
37 anal canal paget's disease 10.3 MLANA CDKN2A
38 vulval paget's disease 10.3 MLANA CDKN2A
39 hypertelorism, microtia, facial clefting syndrome 10.3 FGFR3 FGFR2
40 adult teratoma 10.3 TP53 FGFR2
41 malignant biphasic mesothelioma 10.3 KRT5 KRT10
42 nodular hidradenoma 10.3 KRT5 KRT10
43 muenke syndrome 10.3 FGFR3 FGFR2 FGF10
44 vaginal carcinosarcoma 10.3 TP53 PIK3CA
45 luteoma 10.3 MLANA FGFR3 FGFR2
46 toxicodendron dermatitis 10.3 KRT10 KRT1
47 jackson-weiss syndrome 10.3 FGFR3 FGFR2 FGF10
48 clear cell hidradenoma 10.3 KRT5 KRT10
49 penile urethral cancer 10.3 KRT5 CDKN2A
50 b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2) 10.3 TP53 CDKN2A

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma

Symptoms & Phenotypes for Acanthoma

GenomeRNAi Phenotypes related to Acanthoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.14 CD1B CDKN2A DPH3 FGF10 FGF7 FGFR2
2 no effect GR00402-S-2 10.14 CDKN2A DPH3 FGF10 FGF7 FGFR2 FGFR3

MGI Mouse Phenotypes related to Acanthoma:

45 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.28 CDKN2A DPH3 FGF10 FGFR2 FGFR3 FOXN1
2 nervous system MP:0003631 10.22 CDKN2A DPH3 FGF10 FGF7 FGFR2 FGFR3
3 immune system MP:0005387 10.22 CDKN2A FGF10 FGF7 FGFR2 FGFR3 FOXN1
4 neoplasm MP:0002006 10.11 CDKN2A FGFR2 FGFR3 FOXN1 KRT10 PIK3CA
5 pigmentation MP:0001186 10.07 CDKN2A FGFR2 FOXN1 KRT1 MLANA TP53
6 limbs/digits/tail MP:0005371 10.06 FGF10 FGF7 FGFR2 FGFR3 KRT10 KRT5
7 no phenotypic analysis MP:0003012 10.04 CDKN2A FGFR2 FGFR3 MLANA PIK3CA TP53
8 reproductive system MP:0005389 10 CDKN2A FGF10 FGF7 FGFR2 FGFR3 FOXN1
9 hearing/vestibular/ear MP:0005377 9.98 FGF10 FGFR2 FGFR3 FOXN1 KRT10 TP53
10 craniofacial MP:0005382 9.91 FGF10 FGFR2 FGFR3 KRT10 KRT5 TP53
11 skeleton MP:0005390 9.85 CDKN2A FGF10 FGFR2 FGFR3 FOXN1 GDA
12 vision/eye MP:0005391 9.61 CDKN2A FGF10 FGF7 FGFR2 FGFR3 FOXN1
13 integument MP:0010771 9.5 CDKN2A FGF10 FGF7 FGFR2 FGFR3 FOXN1

Drugs & Therapeutics for Acanthoma

Search Clinical Trials, NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

Organs/tissues related to Acanthoma:

MalaCards : Skin, Uterus, Cervix, Ovary, Prostate, Colon, Breast

Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 455)
# Title Authors PMID Year
1
Dermoscopic findings and histopathological correlation in large cell acanthoma. 62
36005944 2022
2
[Translated article] Reticulated Acanthoma With Sebaceous Differentiation. 62
36240876 2022
3
Follicular Porokeratoma: Report of a New Variant of Porokeratoma (Porokeratotic Acanthoma) and Literature Review. 62
35925572 2022
4
Clear Cell Acanthoma with Malignant Cytologic Features: A Case Report and Review of the Literature. 62
36278542 2022
5
Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation. 62
35238268 2022
6
Condyloma and coincidental epidermodysplasia verruciformis acanthoma positive for human papillomavirus-14 and -21. 62
36039682 2022
7
An unusual case of pilar sheath acanthoma colliding with sebaceous hyperplasia. 62
34044515 2022
8
Diagnostic Pearls of Vulvar Epidermolytic Acanthoma: Case Report. 62
35721331 2022
9
Whole-transcriptome sequencing identifies postzygotic ATP2A2 mutations in a patient misdiagnosed with herpes zoster, confirming the diagnosis of very late-onset segmental Darier disease. 62
35246884 2022
10
Pilomatrical Acanthoma: An Extremely Rare Intraepidermal Variant of Pilomatricoma. 62
35120037 2022
11
Longitudinal subungual acanthoma. 62
34753213 2022
12
Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study. 62
33946063 2022
13
Hypergranulotic Dyskeratotic Acanthoma: Another Histologically Distinctive Acanthoma. 62
33958516 2021
14
Clear Cell Acanthoma: Sural Nerve Entrapment and Neuropathy After Excision. 62
34608085 2021
15
Variability in the Histopathological Diagnosis of Non-Melanocytic Lesions Excised to Exclude Melanoma. 62
35024222 2021
16
Reflectance confocal findings in a large-cell acanthoma with histologic correlation. 62
34522750 2021
17
Bowen's disease occurring on a reticulated acanthoma with sebaceous differentiation: possible malignant transformation. 62
34405809 2021
18
Clinical value of high-resolution dynamic contrast-enhanced (DCE) MRI in diagnosis of cutaneous squamous cell carcinoma. 62
33141995 2021
19
Hyaline Inclusion Acanthoma. 62
33606370 2021
20
Hidden clear cell acanthoma with uncommon dermoscopic findings. 62
34006397 2021
21
Clear Cell Acanthoma with Melanophages Simulating a Spitz Nevus. 62
34414014 2021
22
Non-Invasive Diagnosis of a Facial Tumor Using Dermoscopy and Successful Treatment with 595 nm Pulsed Dye Laser. 62
34079188 2021
23
Reticulated acanthoma with sebaceous differentiation. 62
33912638 2021
24
Cutaneous acantholytic dyskeratotic acanthoma accompanying syringofibroadenomatous hyperplasia with proliferation of mature sebocytes: A case report. 62
33300158 2021
25
Epidermolytic Acanthoma: Findings of a Large Retrospective Study. 62
33290356 2021
26
Clear cell acanthoma. 62
32989899 2021
27
Two Cases of Multiple Epidermolytic Acanthomas Mimicking Verruca Vulgaris. 62
33911795 2020
28
[A case of nasal vestibule acantholytic acanthoma]. 62
33254352 2020
29
Development of clear cell acanthoma during adalimumab therapy: Is it a novel paradoxical cutaneous reaction? 62
32951308 2020
30
Polarizing-specific white lines in a clear cell acanthoma. 62
32885010 2020
31
Epidermolytic acanthoma in a young woman: a case letter. 62
33040803 2020
32
Epidermolytic acanthoma: A case report. 62
33024766 2020
33
Clear Cell Acanthoma: A Review of Clinical and Histologic Variants. 62
32854184 2020
34
Multiple porokeratomas (porokeratotic acanthoma) coexisting with disseminated superficial porokeratosis: Clinical, dermoscopic and pathological observations, and review of published work. 62
32415691 2020
35
The complexity of clear cell acanthoma diagnosis based on the literature review. 62
32792892 2020
36
Pale (Clear) Cell Acanthoma of the Palate. 62
31230231 2020
37
Mutations in KRT10 in epidermolytic acanthoma. 62
32045015 2020
38
Differences in dermoscopic findings between early and mature clear cell acanthoma. 62
32180264 2020
39
Dermoscopy of subungual acantholytic dyskeratotic acanthoma. 62
31532837 2020
40
Successful treatment of acanthoma fissuratum with intralesional triamcinolone acetonide. 62
32274040 2020
41
Onychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases). 62
31436573 2020
42
Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts. 62
30480645 2020
43
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. 62
31078506 2019
44
Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. 62
30839347 2019
45
Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. 62
31559241 2019
46
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 62
30203987 2019
47
Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. 62
30659646 2019
48
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 62
30940575 2019
49
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. 62
30663082 2019
50
Epidermolytic Acanthoma Mimicking Condyloma: A Case Report. 62
31700841 2019

Variations for Acanthoma

Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
2
Show member pathways
12.81 PIK3CA FGFR3 FGFR2 FGF7 FGF10
3
Show member pathways
12.78 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
4 12.73 PIK3CA FGFR3 FGFR2 FGF7 FGF10
5
Show member pathways
12.58 PIK3CA FGFR3 FGFR2 FGF7 FGF10
6
Show member pathways
12.57 TP53 PIK3CA FGFR3 FGFR2 CDKN2A
7
Show member pathways
12.54 FGF10 FGF7 FGFR2 FGFR3 PIK3CA
8
Show member pathways
12.44 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
9
Show member pathways
12.4 PIK3CA FGFR3 FGFR2 FGF7 FGF10
10
Show member pathways
12.34 TP53 PIK3CA FGFR3 FGFR2
11
Show member pathways
12.3 FGFR3 FGFR2 FGF7 FGF10
12
Show member pathways
12.29 FGF10 FGF7 FGFR2 FGFR3 PIK3CA
13 12.22 TP53 FGFR3 FGFR2 FGF7 FGF10
14
Show member pathways
12.21 FGF10 FGF7 FGFR2 FGFR3 PIK3CA
15
Show member pathways
12.12 TP53 PIK3CA FGFR3 FGFR2
16 12.11 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
17
Show member pathways
12.06 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
18
Show member pathways
12.04 PIK3CA FGFR3 FGFR2 FGF7 FGF10
19
Show member pathways
11.92 PIK3CA FGFR3 FGFR2 FGF7 FGF10
20 11.83 PIK3CA FGFR3 FGFR2 FGF7 FGF10
21 11.66 TP53 FGFR3 FGFR2
22 11.63 FGFR3 FGFR2 FGF7 FGF10
24 11.55 TYR TP53 CDKN2A
25 11.48 PIK3CA FGFR3 FGFR2
26 11.48 PIK3CA FGFR3 FGFR2
27 11.33 FGFR3 FGFR2 FGF7
28 11.29 TP53 FGFR3 CDKN2A
29 10.88 TP53 PIK3CA FGFR3 FGFR2 CDKN2A

GO Terms for Acanthoma

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 21)
# Name GO ID Score Top Affiliating Genes
1 animal organ morphogenesis GO:0009887 10.17 FGF10 FGF7 FGFR2 FOXN1
2 hair follicle morphogenesis GO:0031069 9.97 FGF10 FGF7 FGFR2
3 thymus development GO:0048538 9.95 TYR FOXN1 FGF10
4 positive regulation of phospholipase activity GO:0010518 9.9 FGFR3 FGFR2
5 bud elongation involved in lung branching GO:0060449 9.89 FGFR2 FGF10
6 lacrimal gland development GO:0032808 9.88 FGFR2 FGF10
7 otic vesicle formation GO:0030916 9.88 FGFR2 FGF10
8 T cell lineage commitment GO:0002360 9.84 TP53 FOXN1
9 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.83 FGFR2 FGF10
10 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.81 FGFR2 FGF7
11 secretion by lung epithelial cell involved in lung growth GO:0061033 9.78 FGF7 FGF10
12 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.76 FGF7 FGF10
13 fibroblast growth factor receptor signaling pathway GO:0008543 9.76 FGFR3 FGFR2 FGF7 FGF10
14 epidermis morphogenesis GO:0048730 9.73 FGFR2 FGF10
15 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.73 FGF10 FGFR2
16 mammary gland bud formation GO:0060615 9.71 FGF10 FGFR2
17 branch elongation involved in salivary gland morphogenesis GO:0060667 9.67 FGF10 FGFR2
18 mesenchymal cell differentiation involved in lung development GO:0060915 9.62 FGF10 FGFR2
19 branching involved in salivary gland morphogenesis GO:0060445 9.35 FGFR2 FGF7 FGF10
20 epidermis development GO:0008544 9.28 KRT5 KRT10 FOXN1 FGF7 FGF10
21 cellular response to endogenous stimulus GO:0071495 9.26 FGFR2 FGFR3

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 type 2 fibroblast growth factor receptor binding GO:0005111 9.46 FGF7 FGF10
2 fibroblast growth factor receptor activity GO:0005007 9.26 FGFR3 FGFR2
3 structural constituent of skin epidermis GO:0030280 9.1 KRT5 KRT10 KRT1

Sources for Acanthoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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