MCID: ACN010
MIFTS: 34

Acanthoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Acanthoma

MalaCards integrated aliases for Acanthoma:

Name: Acanthoma 12 54 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:174
MeSH 45 D049309
NCIt 51 C7419
UMLS 74 C0846967

Summaries for Acanthoma

NIH Rare Diseases : 54 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  There are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  Though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  The exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  Acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms.

MalaCards based summary : Acanthoma is related to clear cell acanthoma and large cell acanthoma. An important gene associated with Acanthoma is FGFR2 (Fibroblast Growth Factor Receptor 2), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, ovary and testes, and related phenotype is pigmentation.

Wikipedia : 77 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 34.2 FGF10 FGFR2
2 large cell acanthoma 33.8 KRT10 KRT17
3 epidermolytic acanthoma 33.6 KRT1 KRT10
4 keratosis 30.4 KRT1 KRT10
5 keratosis, seborrheic 30.2 KRT10 KRT17
6 bowen's disease 30.2 KRT10 KRT17
7 keratoacanthoma 29.8 KRT10 KRT17
8 pilar sheath acanthoma 12.3
9 acantholytic acanthoma 12.3
10 onychocytic matricoma 11.2
11 psoriasis 10.2
12 posttransplant acute limbic encephalitis 10.2
13 nevus, epidermal 10.2
14 squamous cell carcinoma 10.2
15 apert syndrome 10.1 FGF10 FGFR2
16 basal cell carcinoma, infundibulocystic 10.1 KRT10 KRT17
17 lentigines 10.1
18 muir-torre syndrome 10.1
19 epidermodysplasia verruciformis 1 10.1
20 ichthyosis 10.1
21 melanoma 10.1
22 eccrine acrospiroma 10.1 KRT10 KRT17
23 steatocystoma multiplex 10.0 KRT10 KRT17
24 muenke syndrome 10.0 FGF10 FGFR2
25 eccrine sweat gland neoplasm 10.0 KRT10 KRT17
26 lacrimoauriculodentodigital syndrome 10.0 FGF10 FGFR2
27 pachyonychia congenita 1 10.0 KRT10 KRT17
28 primary cutaneous amyloidosis 9.9 KRT10 KRT17
29 basal cell carcinoma 1 9.9
30 psoriasis 7 9.9
31 psoriasis 11 9.9
32 psoriasis 13 9.9
33 autosomal recessive congenital ichthyosis 9.9
34 squamous cell papilloma 9.9
35 basal cell carcinoma 9.9
36 papilloma 9.9
37 dermatitis 9.9
38 endometriosis 9.9
39 porokeratosis 9.9
40 cutaneous fibrous histiocytoma 9.9
41 cowden syndrome 9.9
42 inverted follicular keratosis 9.9
43 bullous pemphigoid 9.9
44 in situ carcinoma 9.9
45 molluscum contagiosum 9.9
46 inflammatory linear verrucous epidermal nevus 9.9
47 trichofolliculoma 9.9
48 warty dyskeratoma 9.9
49 cholesteatoma of middle ear 9.9 FGFR2 KRT10
50 erythroderma, ichthyosiform, congenital reticular 9.9 KRT1 KRT10

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma

Symptoms & Phenotypes for Acanthoma

MGI Mouse Phenotypes related to Acanthoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 pigmentation MP:0001186 8.8 FGFR2 KRT1 KRT17

Drugs & Therapeutics for Acanthoma

Search Clinical Trials , NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

MalaCards organs/tissues related to Acanthoma:

42
Skin, Ovary, Testes, Uterus

Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 239)
# Title Authors Year
1
Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. ( 30659646 )
2019
2
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. ( 30663082 )
2019
3
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. ( 30940575 )
2019
4
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. ( 31078506 )
2019
5
Image Gallery: Red coral vascular pattern as a new dermoscopic clue for clear cell acanthoma. ( 30604543 )
2019
6
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2018
7
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. ( 28609346 )
2018
8
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. ( 28857272 )
2018
9
Two cases of large cell acanthoma successfully treated with photodynamic therapy. ( 29633447 )
2018
10
Multiple Eruptive Clear Cell Acanthoma. ( 29692468 )
2018
11
Longitudinal subungual acanthoma: one denomination for various clinical presentations. ( 29705997 )
2018
12
Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia. ( 29735169 )
2018
13
Dermoscopic features of clear cell acanthoma. ( 29924237 )
2018
14
Giant clear cell acanthoma with dermatoscopic white lines. ( 30116672 )
2018
15
Clear Cell Acanthoma on the Areola. ( 30261576 )
2018
16
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. ( 30558902 )
2018
17
Acanthoma Fissuratum: Lest we Forget. ( 28405560 )
2017
18
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. ( 28426905 )
2017
19
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. ( 28470879 )
2017
20
Reticulated acanthoma with sebaceous differentiation. ( 28492170 )
2017
21
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. ( 28868008 )
2017
22
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. ( 29085717 )
2017
23
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. ( 29267438 )
2017
24
"String of pearls pattern": report of three cases of non clear-cell acanthoma. ( 29267474 )
2017
25
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. ( 25186214 )
2016
26
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2016
27
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2016
28
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. ( 26825163 )
2016
29
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
30
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. ( 26945829 )
2016
31
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
32
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
33
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
34
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 27814733 )
2016
35
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2015
36
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2015
37
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
38
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2015
39
Porokeratotic acanthoma. ( 25631132 )
2015
40
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? ( 26512188 )
2015
41
An Unusual Location of a Pilar Sheath Acanthoma. ( 26903749 )
2015
42
Pilar Sheath Acanthoma Presenting as a Nevus. ( 26903752 )
2015
43
Reticulated acanthoma with sebaceous differentiation: another sebaceous neoplasm associated with Muir-Torre syndrome? ( 23651324 )
2014
44
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
45
Pilar sheath acanthoma simulating basal cell carcinoma. ( 24566580 )
2014
46
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
47
Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 24890648 )
2014
48
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
49
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
50
Acantholytic dyskeratotic acanthoma: case report and review of the literature. ( 25126453 )
2014

Variations for Acanthoma

Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 FGF10 FGFR2 KRT1 KRT10 KRT17
2
Show member pathways
11.59 KRT1 KRT10 KRT17
3
Show member pathways
11.19 KRT1 KRT17

GO Terms for Acanthoma

Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.96 KRT1 KRT10
2 intermediate filament GO:0005882 8.8 KRT1 KRT10 KRT17

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.73 KRT1 KRT10 KRT17
2 cornification GO:0070268 9.67 KRT1 KRT10 KRT17
3 epidermis development GO:0008544 9.65 FGF10 KRT17
4 wound healing GO:0042060 9.65 FGF10 FGFR2
5 lung development GO:0030324 9.64 FGF10 FGFR2
6 positive regulation of canonical Wnt signaling pathway GO:0090263 9.64 FGF10 FGFR2
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.63 FGF10 FGFR2
8 epithelial cell differentiation GO:0030855 9.63 FGF10 FGFR2
9 inner ear morphogenesis GO:0042472 9.62 FGF10 FGFR2
10 positive regulation of epithelial cell proliferation GO:0050679 9.62 FGF10 FGFR2
11 peptide cross-linking GO:0018149 9.61 KRT1 KRT10
12 protein heterotetramerization GO:0051290 9.61 KRT1 KRT10
13 positive regulation of Wnt signaling pathway GO:0030177 9.6 FGF10 FGFR2
14 lung alveolus development GO:0048286 9.59 FGF10 FGFR2
15 digestive tract development GO:0048565 9.58 FGF10 FGFR2
16 regulation of smoothened signaling pathway GO:0008589 9.58 FGF10 FGFR2
17 embryonic pattern specification GO:0009880 9.57 FGF10 FGFR2
18 embryonic digestive tract morphogenesis GO:0048557 9.55 FGF10 FGFR2
19 branching involved in salivary gland morphogenesis GO:0060445 9.54 FGF10 FGFR2
20 organ growth GO:0035265 9.52 FGF10 FGFR2
21 limb bud formation GO:0060174 9.51 FGF10 FGFR2
22 bud elongation involved in lung branching GO:0060449 9.48 FGF10 FGFR2
23 lacrimal gland development GO:0032808 9.46 FGF10 FGFR2
24 otic vesicle formation GO:0030916 9.43 FGF10 FGFR2
25 epidermis morphogenesis GO:0048730 9.4 FGF10 FGFR2
26 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.37 FGF10 FGFR2
27 branch elongation involved in salivary gland morphogenesis GO:0060667 9.32 FGF10 FGFR2
28 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.26 FGF10 FGFR2
29 mammary gland bud formation GO:0060615 9.16 FGF10 FGFR2
30 mesenchymal cell differentiation involved in lung development GO:0060915 8.96 FGF10 FGFR2
31 hair follicle morphogenesis GO:0031069 8.8 FGF10 FGFR2 KRT17

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 KRT1 KRT10 KRT17
2 structural constituent of epidermis GO:0030280 8.62 KRT1 KRT10

Sources for Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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