MCID: ACN010
MIFTS: 32

Acanthoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Acanthoma

MalaCards integrated aliases for Acanthoma:

Name: Acanthoma 12 53 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:174
MeSH 44 D049309
NCIt 50 C7419
UMLS 73 C0846967

Summaries for Acanthoma

NIH Rare Diseases : 53 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult.  There are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma".  Though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many.  The exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation.  Acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms.

MalaCards based summary : Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is FGF10 (Fibroblast Growth Factor 10), and among its related pathways/superpathways are Developmental Biology and Keratinization. Affiliated tissues include skin, ovary and testes.

Wikipedia : 76 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 34.0 FGF10 FGFR2
2 epidermolytic acanthoma 32.6 KRT1 KRT10 KRT9
3 epidermodysplasia verruciformis 29.6 KRT1 KRT10
4 keratosis 29.3 KRT1 KRT10 KRT9
5 large cell acanthoma 12.3
6 pilar sheath acanthoma 12.3
7 acantholytic acanthoma 12.1
8 onychocytic matricoma 11.0
9 apert syndrome 10.2 FGF10 FGFR2
10 lacrimoauriculodentodigital syndrome 10.2 FGF10 FGFR2
11 muenke syndrome 10.1 FGF10 FGFR2
12 erythroderma, ichthyosiform, congenital reticular 10.1 KRT1 KRT10
13 ichthyosis, cyclic, with epidermolytic hyperkeratosis 10.1 KRT1 KRT10
14 striate palmoplantar keratoderma 10.1 KRT1 KRT10
15 filamentary keratitis 10.0 KRT1 KRT10
16 psoriasis 10.0
17 ichthyosis vulgaris 10.0 KRT1 KRT10
18 nevus, epidermal 10.0
19 squamous cell carcinoma 10.0
20 palmoplantar keratoderma, epidermolytic 10.0 KRT1 KRT9
21 palmoplantar keratoderma, nonepidermolytic 9.9 KRT1 KRT9
22 pfeiffer syndrome 9.9 FGF10 FGFR2
23 muir-torre syndrome 9.9
24 melanoma 9.9
25 cellulitis 9.9
26 bowen's disease 9.9
27 pachyonychia congenita 1 9.9 KRT10 KRT9
28 epidermolysis bullosa simplex 9.9 KRT1 KRT10
29 cholesteatoma of middle ear 9.9 FGFR2 KRT10
30 palmoplantar keratosis 9.8 KRT1 KRT9
31 hypospadias 9.8 FGF10 FGFR2
32 psoriasis 2 9.7
33 basal cell carcinoma 1 9.7
34 psoriasis 7 9.7
35 psoriasis 11 9.7
36 psoriasis 13 9.7
37 adenoiditis 9.7
38 ichthyosis 9.7
39 basal cell carcinoma 9.7
40 papilloma 9.7
41 endometriosis 9.7
42 keratoacanthoma 9.7
43 porokeratosis 9.7
44 inverted follicular keratosis 9.7
45 bullous pemphigoid 9.7
46 molluscum contagiosum 9.7
47 trichofolliculoma 9.7
48 warty dyskeratoma 9.7
49 white sponge nevus 1 9.4 KRT1 KRT10 KRT9
50 ichthyosis bullosa of siemens 9.4 KRT1 KRT10 KRT9

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma

Symptoms & Phenotypes for Acanthoma

Drugs & Therapeutics for Acanthoma

Search Clinical Trials , NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

MalaCards organs/tissues related to Acanthoma:

41
Skin, Ovary, Testes, Uterus

Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 233)
# Title Authors Year
1
Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia. ( 29735169 )
2018
2
Two cases of large cell acanthoma successfully treated with photodynamic therapy. ( 29633447 )
2018
3
Multiple Eruptive Clear Cell Acanthoma. ( 29692468 )
2018
4
Longitudinal subungual acanthoma: one denomination for various clinical presentations. ( 29705997 )
2018
5
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. ( 29090469 )
2018
6
Dermoscopic features of clear cell acanthoma. ( 29924237 )
2018
7
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. ( 29267438 )
2017
8
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. ( 28857272 )
2017
9
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. ( 28426905 )
2017
10
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. ( 28868008 )
2017
11
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. ( 29085717 )
2017
12
Case of podoplanin-positive clear cell acanthoma. ( 28266032 )
2017
13
Reticulated acanthoma with sebaceous differentiation. ( 28492170 )
2017
14
Acanthoma Fissuratum: Lest we Forget. ( 28405560 )
2017
15
"String of pearls pattern": report of three cases of non clear-cell acanthoma. ( 29267474 )
2017
16
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. ( 28470879 )
2017
17
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. ( 28609346 )
2017
18
Epidermolytic Acanthoma of the Genitalia Does Not Show Mutations in KRT1 or KRT10. ( 26825163 )
2016
19
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 27814733 )
2016
20
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. ( 27648388 )
2016
21
Clear Cell Acanthoma of the Areola and Nipple. ( 27206609 )
2016
22
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. ( 27185430 )
2016
23
Disseminated acantholytic acanthomas in a patient with bullous pemphigoid. ( 28007675 )
2016
24
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. ( 26885606 )
2016
25
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. ( 26945829 )
2016
26
Porokeratotic acanthoma. ( 25631132 )
2015
27
Dermoscopy of clear cell acanthoma. ( 25500041 )
2015
28
Pilar Sheath Acanthoma Presenting as a Nevus. ( 26903752 )
2015
29
An Unusual Location of a Pilar Sheath Acanthoma. ( 26903749 )
2015
30
A Case of Multiple Epidermolytic Acanthoma of the Scrotum: Is the Human Papillomavirus a Culprit? ( 26512188 )
2015
31
Clear cell acanthoma on the axilla successfully treated with carbon dioxide laser. ( 25511379 )
2014
32
Dermoscopic features of clear cell acanthoma: five new cases and a review of existing published cases. ( 25495637 )
2014
33
An unusual location of a pilar sheath acanthoma. ( 25368479 )
2014
34
Clear cell acanthoma of the nipple: another report from Italy. ( 24626678 )
2014
35
Topical calcipotriol as a new therapeutic option for the treatment of clear cell acanthoma. ( 25184922 )
2014
36
A rare case of multiple clear cell acanthoma with a relatively rapid development of the lower legs. ( 25607402 )
2014
37
Histopathological correlation to the dermoscopic feature of "string of pearls" in clear cell acanthoma. ( 25151914 )
2014
38
Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. ( 24890648 )
2014
39
Multiple clear cell acanthoma associated with multiple Bowen's disease. ( 24898560 )
2014
40
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. ( 25186214 )
2014
41
Pigmented clear cell acanthoma of the finger simulating pigmented nevus. ( 25267214 )
2014
42
Multiple pigmented clear cell acanthoma in an African patient. ( 25414053 )
2014
43
Clear cell acanthoma on the dorsum of the hand. ( 25353276 )
2014
44
Pilar sheath acanthoma simulating basal cell carcinoma. ( 24566580 )
2014
45
Large cell acanthoma: a variant of solar lentigo with cellular hypertrophy. ( 24917472 )
2014
46
Large cell acanthoma: a debate throughout the decades. ( 24520512 )
2014
47
Acantholytic dyskeratotic acanthoma: case report and review of the literature. ( 25126453 )
2014
48
Fast-growing 'giant' clear cell acanthoma detected by dermoscopy during treatment with infliximab in a psoriatic patient. ( 24750337 )
2014
49
Disseminated epidermolytic acanthoma with partial response to calcipotriol ointment. ( 23083445 )
2013
50
A shiny red papule in an older person. Clear cell acanthoma. ( 23944729 )
2013

Variations for Acanthoma

Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.23 FGF10 FGFR2 KRT1 KRT10 KRT9
2
Show member pathways
11.59 KRT1 KRT10 KRT9

GO Terms for Acanthoma

Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 9.16 KRT1 KRT10
2 extracellular matrix GO:0031012 9.13 FGF10 FGFR2 KRT1
3 intermediate filament GO:0005882 8.8 KRT1 KRT10 KRT9

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 9.72 KRT1 KRT10 KRT9
2 epidermis development GO:0008544 9.65 FGF10 KRT9
3 phosphatidylinositol phosphorylation GO:0046854 9.65 FGF10 FGFR2
4 cornification GO:0070268 9.65 KRT1 KRT10 KRT9
5 lung development GO:0030324 9.64 FGF10 FGFR2
6 wound healing GO:0042060 9.64 FGF10 FGFR2
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.63 FGF10 FGFR2
8 epithelial cell differentiation GO:0030855 9.63 FGF10 FGFR2
9 inner ear morphogenesis GO:0042472 9.62 FGF10 FGFR2
10 positive regulation of epithelial cell proliferation GO:0050679 9.62 FGF10 FGFR2
11 peptide cross-linking GO:0018149 9.61 KRT1 KRT10
12 phosphatidylinositol-3-phosphate biosynthetic process GO:0036092 9.61 FGF10 FGFR2
13 digestive tract development GO:0048565 9.6 FGF10 FGFR2
14 positive regulation of Wnt signaling pathway GO:0030177 9.59 FGF10 FGFR2
15 lung alveolus development GO:0048286 9.58 FGF10 FGFR2
16 hair follicle morphogenesis GO:0031069 9.58 FGF10 FGFR2
17 embryonic pattern specification GO:0009880 9.57 FGF10 FGFR2
18 regulation of smoothened signaling pathway GO:0008589 9.56 FGF10 FGFR2
19 embryonic digestive tract morphogenesis GO:0048557 9.54 FGF10 FGFR2
20 organ growth GO:0035265 9.52 FGF10 FGFR2
21 limb bud formation GO:0060174 9.51 FGF10 FGFR2
22 branching involved in salivary gland morphogenesis GO:0060445 9.49 FGF10 FGFR2
23 bud elongation involved in lung branching GO:0060449 9.46 FGF10 FGFR2
24 otic vesicle formation GO:0030916 9.43 FGF10 FGFR2
25 epidermis morphogenesis GO:0048730 9.4 FGF10 FGFR2
26 lacrimal gland development GO:0032808 9.37 FGF10 FGFR2
27 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.32 FGF10 FGFR2
28 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.26 FGF10 FGFR2
29 mammary gland bud formation GO:0060615 9.16 FGF10 FGFR2
30 branch elongation involved in salivary gland morphogenesis GO:0060667 8.96 FGF10 FGFR2
31 mesenchymal cell differentiation involved in lung development GO:0060915 8.62 FGF10 FGFR2

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.16 FGF10 FGFR2
2 1-phosphatidylinositol-3-kinase activity GO:0016303 8.96 FGF10 FGFR2
3 structural constituent of epidermis GO:0030280 8.62 KRT1 KRT10

Sources for Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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