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MCID: ACN010
MIFTS: 33

Acanthoma

Categories: Cancer diseases, Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways
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Aliases & Classifications for Acanthoma

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MalaCards integrated aliases for Acanthoma:

Name: Acanthoma 12 52 15 71

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:174
MeSH 43 D049309
NCIt 49 C7419
UMLS 71 C0846967
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Summaries for Acanthoma

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NIH Rare Diseases : 52 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult. There are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell ", and "melanoacanthoma". Though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many. The exact cause of acanthoma is not known; it is sometimes called a benign tumor , and sometimes described as the result of inflammation . Acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms.

MalaCards based summary : Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is FGF7 (Fibroblast Growth Factor 7), and among its related pathways/superpathways are Developmental Biology and Pathways in cancer. Affiliated tissues include skin, ovary and uterus.

Wikipedia : 74 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

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Related Diseases for Acanthoma

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Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 33.8 FGFR2 FGF7 FGF10 CLEC2A
2 epidermolytic acanthoma 33.5 TCHH KRT1
3 pilar sheath acanthoma 33.4 TCHH CLEC2A
4 keratosis, seborrheic 30.5 OCM2 OCM CLEC2A
5 nevus, epidermal 29.8 KRT1 FGFR2
6 large cell acanthoma 12.6
7 acantholytic acanthoma 12.4
8 onychocytic matricoma 11.7
9 keratosis 10.8
10 epidermolytic hyperkeratosis 10.6
11 autosomal dominant epidermolytic ichthyosis 10.6
12 erythrokeratoderma ''en cocardes'' 10.6
13 inverted follicular keratosis 10.6
14 posttransplant acute limbic encephalitis 10.4
15 lentigines 10.4
16 papilloma 10.4
17 psoriasis 10.4
18 pustulosis of palm and sole 10.4
19 actinic keratosis 10.4
20 ichthyosis 10.3
21 lichen planus 10.3
22 muir-torre syndrome 10.3
23 keratoacanthoma 10.3
24 bowen's disease 10.3
25 congenital heart defects, hamartomas of tongue, and polysyndactyly 10.2
26 basal cell carcinoma 10.2
27 dermatitis 10.2
28 adenoma 10.2
29 dowling-degos disease 1 10.2
30 epidermodysplasia verruciformis 1 10.2
31 squamous cell papilloma 10.2
32 squamous cell carcinoma 10.2
33 porokeratosis 10.2
34 in situ carcinoma 10.2
35 pemphigus 10.2
36 dacryocystocele 10.2 FGFR2 FGF10
37 bronchopulmonary dysplasia 10.1 FGF7 FGF10
38 varicose veins 10.1
39 dermatitis, atopic 10.1
40 melanoma 10.1
41 skin carcinoma 10.1
42 skin disease 10.1
43 cutaneous fibrous histiocytoma 10.1
44 eccrine acrospiroma 10.1
45 bullous pemphigoid 10.1
46 molluscum contagiosum 10.1
47 bowenoid papulosis 10.1
48 trichofolliculoma 10.1
49 warty dyskeratoma 10.1
50 pemphigus vegetans 10.1

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma
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Symptoms & Phenotypes for Acanthoma

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Drugs & Therapeutics for Acanthoma

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Search Clinical Trials , NIH Clinical Center for Acanthoma

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

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MalaCards organs/tissues related to Acanthoma:

40
Skin, Ovary, Uterus, Prostate, Cervix, Colon, Liver
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Publications for Acanthoma

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Articles related to Acanthoma:

(show top 50) (show all 414)
# Title Authors PMID Year
1
Onychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases). 61
31436573 2020
2
Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts. 61
30480645 2020
3
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. 61
31078506 2019
4
Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. 61
30839347 2019
5
Dermoscopy of subungual acantholytic dyskeratotic acanthoma. 61
31532837 2019
6
Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. 61
31559241 2019
7
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 61
30203987 2019
8
Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. 61
30659646 2019
9
Pale (Clear) Cell Acanthoma of the Palate. 61
31230231 2019
10
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 61
30940575 2019
11
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. 61
30663082 2019
12
Epidermolytic Acanthoma Mimicking Condyloma: A Case Report. 61
31700841 2019
13
Multiple acantholytic dyskeratotic acanthomas in a liver-transplant recipient. 61
31046909 2019
14
Onychocytic matricoma. 61
31090828 2019
15
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. 61
30558902 2019
16
Image Gallery: Red coral vascular pattern as a new dermoscopic clue for clear cell acanthoma. 61
30604543 2019
17
Clear Cell Acanthoma with Atypical Location -Case Report and Literature Review. 61
31123619 2018
18
Longitudinal subungual acanthoma: one denomination for various clinical presentations. 61
29705997 2018
19
Clear Cell Acanthoma on the Areola. 61
30261576 2018
20
Giant clear cell acanthoma with dermatoscopic white lines. 61
30116672 2018
21
Two cases of large cell acanthoma successfully treated with photodynamic therapy. 61
29633447 2018
22
Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia. 61
29735169 2018
23
Dermoscopic features of clear cell acanthoma. 61
29924237 2018
24
Multiple Eruptive Clear Cell Acanthoma. 61
29692468 2018
25
Case of podoplanin-positive clear cell acanthoma. 61
28266032 2018
26
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. 61
28857272 2018
27
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. 61
28609346 2018
28
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. 61
29090469 2018
29
Familial seborrhoeic keratosis associated with multiple 'pure reticulated acanthomas' and infundibulocystic basal cell carcinomas. 61
28627087 2017
30
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. 61
28426905 2017
31
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. 61
28470879 2017
32
Germinotropic Onychocytic Matricoma: A New Histopathologic Subtype of Onychocytic Matricoma in the Light of the Microanatomy of the Normal Nail Unit, With Special Reference to Nail Mesenchyme. 61
28169867 2017
33
Reticulated acanthoma with sebaceous differentiation mimicking melanoma. 61
29085717 2017
34
Reticulated acanthoma with sebaceous differentiation. 61
28492170 2017
35
Epidermolytic Acanthoma on Fingers, Mimicking Flat Warts. 61
28868008 2017
36
[Multiple epidermolytic acanthomas of the genitalia]. 61
27789051 2017
37
Acanthoma Fissuratum: Lest we Forget. 61
28405560 2017
38
Multiple clear cell acanthomas and a sebaceous lymphadenoma presenting in a patient with Cowden syndrome - a case report. 61
27682856 2017
39
"String of pearls pattern": report of three cases of non clear-cell acanthoma. 61
29267474 2017
40
Bilateral clear cell acanthoma of the areola and nipple: good response to topical corticosteroids. 61
29267438 2017
41
Clear Cell Acanthoma of the Areola and Nipple. 61
27206609 2016
42
Retraction Note: Clinico-histopathologic and outcome features of cutaneous infundibular keratinizing acanthoma: a case report and literature review. 61
27814733 2016
43
Case of isolated epidermolytic acanthoma: Genetic and immunohistochemical analysis. 61
26945829 2016
44
Nuclear factor XIIIa staining (clone AC-1A1 mouse monoclonal) is a sensitive and specific marker to discriminate sebaceous proliferations from other cutaneous clear cell neoplasms. 61
27153339 2016
45
Acantholytic Acanthoma of the Eyelid: Unusual Presentation. 61
25186214 2016
46
Malignant Clear Cell Acanthoma: Report of a Rare Case of Clear Cell Acanthoma-Like Tumor With Malignant Features. 61
26885606 2016
47
In vivo reflectance confocal microscopy features of a large cell acanthoma: report of a case. 61
27648388 2016
48
Clinicopathological and dermoscopic features of angio-eccrine hyperplasia in clear cell acanthoma. 61
27185430 2016
49
Presentation of epidermolytic acanthomas as multiple tan papules on the vulva. 61
27034569 2016
50
Multiple pigmented clear cell acanthoma in an African patient. 61
25414053 2016
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Variations for Acanthoma

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Expression for Acanthoma

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Search GEO for disease gene expression data for Acanthoma.
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Pathways for Acanthoma

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Pathways related to Acanthoma according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Developmental Biology 65
Show member pathways
 13.09 TCHH KRT1 FGFR2 FGF7 FGF10
2
Pathways in cancer 36
12.28 FGFR2 FGF7 FGF10 CALML3
3
Negative regulation of FGFR3 signaling 65
Show member pathways
 12.2 FGFR2 FGF7 FGF10
4
RhoGDI Pathway 63
Show member pathways
 11.99 FGFR2 FGF7 FGF10
5
mTOR signalling 65
Show member pathways
 11.98 FGFR2 FGF7 FGF10
6
Development FGFR signaling pathway 22
Show member pathways
 11.96 FGFR2 FGF7 FGF10
7
Ras signaling pathway 36
Show member pathways
 11.9 FGFR2 FGF7 FGF10 CALML3
8
Signaling by FGFR2 65
Show member pathways
 11.79 FGFR2 FGF7 FGF10
9
Signaling by FGFR2 in disease 65
Show member pathways
 11.53 FGFR2 FGF7 FGF10
10
Glioma 36
Show member pathways
 11.52 FGFR2 FGF7 FGF10 CALML3
11
G-protein signaling_RhoA regulation pathway 22
11.36 FGFR2 FGF7 FGF10
12
Vemurafenib Pathway, Pharmacodynamics 60
11.09 FGFR2 FGF7
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GO Terms for Acanthoma

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Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornified envelope GO:0001533 8.62 TCHH KRT1

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 33)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.82 FGFR2 FGF7 FGF10
2 positive regulation of protein kinase B signaling GO:0051897 9.79 FGFR2 FGF7 FGF10
3 lung development GO:0030324 9.74 FGFR2 FGF10 CCDC39
4 fibroblast growth factor receptor signaling pathway GO:0008543 9.73 FGFR2 FGF7 FGF10
5 actin cytoskeleton reorganization GO:0031532 9.66 FGF7 FGF10
6 positive chemotaxis GO:0050918 9.65 FGF7 FGF10
7 positive regulation of cell division GO:0051781 9.65 FGFR2 FGF7
8 positive regulation of epithelial cell proliferation GO:0050679 9.65 FGFR2 FGF7 FGF10
9 positive regulation of Wnt signaling pathway GO:0030177 9.64 FGFR2 FGF10
10 lung alveolus development GO:0048286 9.64 FGFR2 FGF10
11 digestive tract development GO:0048565 9.63 FGFR2 FGF10
12 protein localization to cell surface GO:0034394 9.63 FGF7 FGF10
13 regulation of smoothened signaling pathway GO:0008589 9.62 FGFR2 FGF10
14 embryonic pattern specification GO:0009880 9.61 FGFR2 FGF10
15 embryonic digestive tract morphogenesis GO:0048557 9.61 FGFR2 FGF10
16 positive regulation of keratinocyte proliferation GO:0010838 9.6 FGF7 FGF10
17 positive regulation of keratinocyte migration GO:0051549 9.59 FGF7 FGF10
18 organ growth GO:0035265 9.58 FGFR2 FGF10
19 limb bud formation GO:0060174 9.58 FGFR2 FGF10
20 bud elongation involved in lung branching GO:0060449 9.55 FGFR2 FGF10
21 epidermis morphogenesis GO:0048730 9.54 FGFR2 FGF10
22 lacrimal gland development GO:0032808 9.52 FGFR2 FGF10
23 otic vesicle formation GO:0030916 9.51 FGFR2 FGF10
24 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.49 FGFR2 FGF7
25 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.46 FGFR2 FGF10
26 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.43 FGF7 FGF10
27 secretion by lung epithelial cell involved in lung growth GO:0061033 9.4 FGF7 FGF10
28 mesenchymal cell differentiation involved in lung development GO:0060915 9.37 FGFR2 FGF10
29 branch elongation involved in salivary gland morphogenesis GO:0060667 9.32 FGFR2 FGF10
30 mammary gland bud formation GO:0060615 9.26 FGFR2 FGF10
31 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.16 FGFR2 FGF10
32 hair follicle morphogenesis GO:0031069 9.13 FGFR2 FGF7 FGF10
33 branching involved in salivary gland morphogenesis GO:0060445 8.8 FGFR2 FGF7 FGF10

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.46 TCHH OCM2 OCM CALML3
2 chemoattractant activity GO:0042056 9.26 FGF7 FGF10
3 fibroblast growth factor receptor binding GO:0005104 8.96 FGF7 FGF10
4 heparin binding GO:0008201 8.8 FGFR2 FGF7 FGF10
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Sources for Acanthoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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