Acanthoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Acanthoma

MalaCards integrated aliases for Acanthoma:

Name: Acanthoma ¹¹ ¹⁹ ¹⁴ ⁷¹ ⁷⁵

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Skin diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:174

MeSH ⁴³ D049309

NCIt ⁴⁹ C7419

UMLS ⁷¹ C0846967

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Summaries for Acanthoma

GARD: ¹⁹ "An Acanthoma is a small, reddish bump that usually develops on the skin of an older adult. There are several types of Acanthoma, including ""acantholytic"", ""epidermolytic"", ""clear cell"", and ""melanoAcanthoma"". Though most individuals have only one Acanthoma, some people may develop many. The exact cause of Acanthoma is not known."

MalaCards based summary: Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is KRT10 (Keratin 10), and among its related pathways/superpathways are PIP3 activates AKT signaling and Downstream signaling of activated FGFR2. Affiliated tissues include skin, uterus and cervix, and related phenotypes are growth/size/body region and nervous system

Wikipedia: ⁷⁵ An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

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Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 298)

#	Related Disease	Score	Top Affiliating Genes
1	clear cell acanthoma	32.9	KRT5 KRT10
2	epidermolytic acanthoma	32.6	KRT10 KRT1
3	large cell acanthoma	31.5	TP53 MLANA KRT5 KRT10 CD1B
4	autosomal dominant epidermolytic ichthyosis	31.2	KRT10 KRT1
5	epidermolytic hyperkeratosis	30.8	KRT5 KRT10 KRT1
6	muir-torre syndrome	30.5	TP53 KRT5 CDKN2A
7	keratoacanthoma	30.5	TP53 PIK3CA KRT10
8	lichen planus	30.3	TP53 KRT10 KRT1
9	anogenital venereal wart	30.3	TP53 TMC8 CDKN2A
10	ichthyosis bullosa of siemens	30.2	KRT10 KRT1
11	actinic keratosis	30.1	TP53 TMC8 MLANA KRT10 CDKN2A
12	nevus, epidermal	30.1	PIK3CA KRT10 KRT1 FGFR3 FGFR2
13	eccrine acrospiroma	30.1	KRT5 KRT10
14	keratosis	30.0	TP53 TMC8 PIK3CA KRT5 KRT10 KRT1
15	papilloma	30.0	TP53 KRT5 KRT10 KRT1 FGFR3 CDKN2A
16	epidermodysplasia verruciformis 1	29.9	TP53 TMC8 TMC6 CDKN2A
17	porokeratosis	29.9	TP53 TMC8 KRT10 KRT1 FGFR3 FGFR2
18	anus cancer	29.9	TP53 PIK3CA CDKN2A
19	squamous cell carcinoma	29.8	TP53 PIK3CA FGFR3 FGFR2 CDKN2A
20	common wart	29.8	TP53 TMC8 TMC6
21	skin squamous cell carcinoma	29.7	TP53 KRT5 KRT10 CDKN2A
22	basal cell carcinoma	29.5	TYR TP53 KRT5 KRT10 KRT1 CDKN2A
23	melanoma in congenital melanocytic nevus	29.3	TYR TP53 MLANA CDKN2A
24	skin benign neoplasm	29.1	TYR TP53 MLANA KRT5 KRT1 FGFR3
25	skin carcinoma	28.9	TYR TP53 TMC8 TMC6 MLANA KRT5
26	skin disease	28.0	TYR TP53 PIK3CA MLANA KRT5 KRT10
27	keratosis, seborrheic	27.3	TYR TP53 TMC8 TMC6 PIK3CA MLANA
28	pilar sheath acanthoma	11.5
29	acantholytic acanthoma	11.2
30	onychocytic matricoma	11.1
31	erythrokeratoderma ''en cocardes''	10.4
32	hemifacial hyperplasia	10.4	FGFR3 FGFR2
33	plagiocephaly	10.4	FGFR3 FGFR2
34	posttransplant acute limbic encephalitis	10.3
35	testicular spermatocytic seminoma	10.3	FGFR3 FGFR2
36	ichthyosis with confetti	10.3	KRT10 KRT1
37	anal canal paget's disease	10.3	MLANA CDKN2A
38	vulval paget's disease	10.3	MLANA CDKN2A
39	hypertelorism, microtia, facial clefting syndrome	10.3	FGFR3 FGFR2
40	adult teratoma	10.3	TP53 FGFR2
41	malignant biphasic mesothelioma	10.3	KRT5 KRT10
42	nodular hidradenoma	10.3	KRT5 KRT10
43	muenke syndrome	10.3	FGFR3 FGFR2 FGF10
44	vaginal carcinosarcoma	10.3	TP53 PIK3CA
45	luteoma	10.3	MLANA FGFR3 FGFR2
46	toxicodendron dermatitis	10.3	KRT10 KRT1
47	jackson-weiss syndrome	10.3	FGFR3 FGFR2 FGF10
48	clear cell hidradenoma	10.3	KRT5 KRT10
49	penile urethral cancer	10.3	KRT5 CDKN2A
50	b-lymphoblastic leukemia/lymphoma with t(9;22)(q34.1;q11.2)	10.3	TP53 CDKN2A

Graphical network of the top 20 diseases related to Acanthoma:

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Symptoms & Phenotypes for Acanthoma

GenomeRNAi Phenotypes related to Acanthoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.14	CD1B CDKN2A DPH3 FGF10 FGF7 FGFR2
2	no effect	GR00402-S-2	10.14	CDKN2A DPH3 FGF10 FGF7 FGFR2 FGFR3

MGI Mouse Phenotypes related to Acanthoma:

⁴⁵ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	growth/size/body region	MP:0005378	10.28	CDKN2A DPH3 FGF10 FGFR2 FGFR3 FOXN1
2	nervous system	MP:0003631	10.22	CDKN2A DPH3 FGF10 FGF7 FGFR2 FGFR3
3	immune system	MP:0005387	10.22	CDKN2A FGF10 FGF7 FGFR2 FGFR3 FOXN1
4	neoplasm	MP:0002006	10.11	CDKN2A FGFR2 FGFR3 FOXN1 KRT10 PIK3CA
5	pigmentation	MP:0001186	10.07	CDKN2A FGFR2 FOXN1 KRT1 MLANA TP53
6	limbs/digits/tail	MP:0005371	10.06	FGF10 FGF7 FGFR2 FGFR3 KRT10 KRT5
7	no phenotypic analysis	MP:0003012	10.04	CDKN2A FGFR2 FGFR3 MLANA PIK3CA TP53
8	reproductive system	MP:0005389	10	CDKN2A FGF10 FGF7 FGFR2 FGFR3 FOXN1
9	hearing/vestibular/ear	MP:0005377	9.98	FGF10 FGFR2 FGFR3 FOXN1 KRT10 TP53
10	craniofacial	MP:0005382	9.91	FGF10 FGFR2 FGFR3 KRT10 KRT5 TP53
11	skeleton	MP:0005390	9.85	CDKN2A FGF10 FGFR2 FGFR3 FOXN1 GDA
12	vision/eye	MP:0005391	9.61	CDKN2A FGF10 FGF7 FGFR2 FGFR3 FOXN1
13	integument	MP:0010771	9.5	CDKN2A FGF10 FGF7 FGFR2 FGFR3 FOXN1

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Drugs & Therapeutics for Acanthoma

Search Clinical Trials, NIH Clinical Center for Acanthoma

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Genetic Tests for Acanthoma

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Anatomical Context for Acanthoma

Organs/tissues related to Acanthoma:

MalaCards : Skin, Uterus, Cervix, Ovary, Prostate, Colon, Breast

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Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 455)

#	Title	Authors	PMID	Year
1	Dermoscopic findings and histopathological correlation in large cell acanthoma. ⁶²	Jung JH...Jang MS	36005944	2022
2	[Translated article] Reticulated Acanthoma With Sebaceous Differentiation. ⁶²	Valencia VG...Manrique MJV	36240876	2022
3	Follicular Porokeratoma: Report of a New Variant of Porokeratoma (Porokeratotic Acanthoma) and Literature Review. ⁶²	Kanitakis J...Jullien D	35925572	2022
4	Clear Cell Acanthoma with Malignant Cytologic Features: A Case Report and Review of the Literature. ⁶²	Melson G...Brem CE	36278542	2022
5	Multiple eruptive clear cell acanthomas successfully treated with CO2 laser ablation. ⁶²	Drumm C...Eustace K	35238268	2022
6	Condyloma and coincidental epidermodysplasia verruciformis acanthoma positive for human papillomavirus-14 and -21. ⁶²	Bartley B...Torres-Cabala CA	36039682	2022
7	An unusual case of pilar sheath acanthoma colliding with sebaceous hyperplasia. ⁶²	Zocchi L...Ribero S	34044515	2022
8	Diagnostic Pearls of Vulvar Epidermolytic Acanthoma: Case Report. ⁶²	Farahbakhsh N...Vladimir V	35721331	2022
9	Whole-transcriptome sequencing identifies postzygotic ATP2A2 mutations in a patient misdiagnosed with herpes zoster, confirming the diagnosis of very late-onset segmental Darier disease. ⁶²	Mohaghegh F...Uitto J	35246884	2022
10	Pilomatrical Acanthoma: An Extremely Rare Intraepidermal Variant of Pilomatricoma. ⁶²	He L...Hosler GA	35120037	2022
11	Longitudinal subungual acanthoma. ⁶²	Baran R...Cannata G	34753213	2022
12	Application of Cellular Resolution Full-Field Optical Coherence Tomography in vivo for the Diagnosis of Skin Tumours and Inflammatory Skin Diseases: A Pilot Study. ⁶²	Wang YJ...Wu YH	33946063	2022
13	Hypergranulotic Dyskeratotic Acanthoma: Another Histologically Distinctive Acanthoma. ⁶²	Lee SH...Lee JB	33958516	2021
14	Clear Cell Acanthoma: Sural Nerve Entrapment and Neuropathy After Excision. ⁶²	Bennett M...Sinclair R	34608085	2021
15	Variability in the Histopathological Diagnosis of Non-Melanocytic Lesions Excised to Exclude Melanoma. ⁶²	Katz I...Prow T	35024222	2021
16	Reflectance confocal findings in a large-cell acanthoma with histologic correlation. ⁶²	Blumstein AJ...Correa-Selm L	34522750	2021
17	Bowen's disease occurring on a reticulated acanthoma with sebaceous differentiation: possible malignant transformation. ⁶²	Yoshida A...Yamamoto O	34405809	2021
18	Clinical value of high-resolution dynamic contrast-enhanced (DCE) MRI in diagnosis of cutaneous squamous cell carcinoma. ⁶²	Tang M...Li Y	33141995	2021
19	Hyaline Inclusion Acanthoma. ⁶²	Tran TAN...Linos K	33606370	2021
20	Hidden clear cell acanthoma with uncommon dermoscopic findings. ⁶²	Alvarez-Salafranca M...Ara-Martin M	34006397	2021
21	Clear Cell Acanthoma with Melanophages Simulating a Spitz Nevus. ⁶²	de Oliveira TA...Argenziano G	34414014	2021
22	Non-Invasive Diagnosis of a Facial Tumor Using Dermoscopy and Successful Treatment with 595 nm Pulsed Dye Laser. ⁶²	Ahn GR...Lee HW	34079188	2021
23	Reticulated acanthoma with sebaceous differentiation. ⁶²	Molinelli E...Offidani A	33912638	2021
24	Cutaneous acantholytic dyskeratotic acanthoma accompanying syringofibroadenomatous hyperplasia with proliferation of mature sebocytes: A case report. ⁶²	Tanaka C...Furihata M	33300158	2021
25	Epidermolytic Acanthoma: Findings of a Large Retrospective Study. ⁶²	Roy SF...McNiff JM	33290356	2021
26	Clear cell acanthoma. ⁶²	Wagner G...Sachse MM	32989899	2021
27	Two Cases of Multiple Epidermolytic Acanthomas Mimicking Verruca Vulgaris. ⁶²	Byun HJ...Lee DY	33911795	2020
28	[A case of nasal vestibule acantholytic acanthoma]. ⁶²	Zhu B...Wang J	33254352	2020
29	Development of clear cell acanthoma during adalimumab therapy: Is it a novel paradoxical cutaneous reaction? ⁶²	Polat Ekinci A...Buyukbabani N	32951308	2020
30	Polarizing-specific white lines in a clear cell acanthoma. ⁶²	Deitermann AM...Jaimes JP	32885010	2020
31	Epidermolytic acanthoma in a young woman: a case letter. ⁶²	Zhao P...Chen L	33040803	2020
32	Epidermolytic acanthoma: A case report. ⁶²	Ginsberg AS...Terlizzi JP	33024766	2020
33	Clear Cell Acanthoma: A Review of Clinical and Histologic Variants. ⁶²	Usmani A...Qasim S	32854184	2020
34	Multiple porokeratomas (porokeratotic acanthoma) coexisting with disseminated superficial porokeratosis: Clinical, dermoscopic and pathological observations, and review of published work. ⁶²	Xu X...Li W	32415691	2020
35	The complexity of clear cell acanthoma diagnosis based on the literature review. ⁶²	Pogorzelska-Antkowiak A...Antkowiak ?	32792892	2020
36	Pale (Clear) Cell Acanthoma of the Palate. ⁶²	Argyris PP...Koutlas IG	31230231	2020
37	Mutations in KRT10 in epidermolytic acanthoma. ⁶²	Cheraghlou S...Choate KA	32045015	2020
38	Differences in dermoscopic findings between early and mature clear cell acanthoma. ⁶²	Iseki K...Matsue H	32180264	2020
39	Dermoscopy of subungual acantholytic dyskeratotic acanthoma. ⁶²	Carlioz V...Thomas L	31532837	2020
40	Successful treatment of acanthoma fissuratum with intralesional triamcinolone acetonide. ⁶²	Ramroop S	32274040	2020
41	Onychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases). ⁶²	Perrin C	31436573	2020
42	Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts. ⁶²	Irwin S...McCluggage WG	30480645	2020
43	Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. ⁶²	Argyris PP...Koutlas IG	31078506	2019
44	Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. ⁶²	Fernandez-Flores A...Fonseca E	30839347	2019
45	Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. ⁶²	Jakobiec FA...Mandeville J	31559241	2019
46	Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. ⁶²	Chan MP	30203987	2019
47	Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. ⁶²	Kiyohara T...Tanimura H	30659646	2019
48	In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. ⁶²	Wang YJ...Wu YH	30940575	2019
49	Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. ⁶²	Roy SF...McNiff JM	30663082	2019
50	Epidermolytic Acanthoma Mimicking Condyloma: A Case Report. ⁶²	Dupont A...Kaya G	31700841	2019

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Genes for Acanthoma

Genes related to Acanthoma (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	KRT10	Keratin 10	Protein Coding	13.38	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
2	FGF7	Fibroblast Growth Factor 7	Protein Coding	11.71	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
3	FGFR2	Fibroblast Growth Factor Receptor 2	Protein Coding	11.52	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
4	FGF10	Fibroblast Growth Factor 10	Protein Coding	10.72	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
5	FGFR3	Fibroblast Growth Factor Receptor 3	Protein Coding	6.75	DISEASES inferred ¹⁴
6	MLANA	Melan-A	Protein Coding	6.62	DISEASES inferred ¹⁴
7	TMC8	Transmembrane Channel Like 8	Protein Coding	5.94	DISEASES inferred ¹⁴
8	PIK3CA	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha	Protein Coding	5.68	DISEASES inferred ¹⁴
9	KRT1	Keratin 1	Protein Coding	5.62	DISEASES inferred ¹⁴
10	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	5.56	DISEASES inferred ¹⁴
11	GDA	Guanine Deaminase	Protein Coding	5.53	DISEASES inferred ¹⁴
12	TP53	Tumor Protein P53	Protein Coding	5.42	DISEASES inferred ¹⁴
13	KRT5	Keratin 5	Protein Coding	5.39	DISEASES inferred ¹⁴
14	PHLDA1	Pleckstrin Homology Like Domain Family A Member 1	Protein Coding	5.35	DISEASES inferred ¹⁴
15	TMC6	Transmembrane Channel Like 6	Protein Coding	5.34	DISEASES inferred ¹⁴
16	DPH3	Diphthamide Biosynthesis 3	Protein Coding	5.33	DISEASES inferred ¹⁴
17	CD1B	CD1b Molecule	Protein Coding	5.32	DISEASES inferred ¹⁴
18	TYR	Tyrosinase	Protein Coding	5.31	DISEASES inferred ¹⁴
19	FOXN1	Forkhead Box N1	Protein Coding	5.3	DISEASES inferred ¹⁴

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Variations for Acanthoma

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Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

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Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	PIP3 activates AKT signaling ⁶⁶ Show member pathways Intracellular signaling by second messengers ⁶⁶ PTEN Regulation ⁶⁶ Regulation of PTEN gene transcription ⁶⁶ Regulation of PTEN localization ⁶⁶	12.96	TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
2	Downstream signaling of activated FGFR2 ⁶⁶ Show member pathways Activated NTRK2 signals through CDK5 ⁶⁶ Activated NTRK2 signals through FRS2 and FRS3 ⁶⁶ Activated NTRK2 signals through FYN ⁶⁶ Activated NTRK2 signals through PI3K ⁶⁶ Activated NTRK2 signals through PLCG1 ⁶⁶ Activated NTRK2 signals through RAS ⁶⁶ Activated point mutants of FGFR2 ⁶⁶ BDNF activates NTRK2 (TRKB) signaling ⁶⁶ betaKlotho-mediated ligand binding ⁶⁶ Downstream signaling of activated FGFR1 ⁶⁶ Downstream signaling of activated FGFR3 ⁶⁶ Downstream signaling of activated FGFR4 ⁶⁶ FGFR2c ligand binding and activation ⁶⁶ FGFR4 ligand binding and activation ⁶⁶ FGFR4 mutant receptor activation ⁶⁶ FRS-mediated FGFR1 signaling ⁶⁶ FRS-mediated FGFR2 signaling ⁶⁶ FRS-mediated FGFR3 signaling ⁶⁶ FRS-mediated FGFR4 signaling ⁶⁶ Inhibition of Ribosome Biogenesis by p19(ARF) ⁶⁴ NTF3 activates NTRK2 (TRKB) signaling ⁶⁶ NTF4 activates NTRK2 (TRKB) signaling ⁶⁶ NTRK2 activates RAC1 ⁶⁶ Phospholipase C-mediated cascade: FGFR1 ⁶⁶ Phospholipase C-mediated cascade; FGFR2 ⁶⁶ Phospholipase C-mediated cascade; FGFR3 ⁶⁶ Phospholipase C-mediated cascade; FGFR4 ⁶⁶ PI-3K cascade:FGFR1 ⁶⁶ PI-3K cascade:FGFR2 ⁶⁶ PI-3K cascade:FGFR3 ⁶⁶ PI-3K cascade:FGFR4 ⁶⁶ SHC-mediated cascade:FGFR1 ⁶⁶ SHC-mediated cascade:FGFR2 ⁶⁶ SHC-mediated cascade:FGFR3 ⁶⁶ SHC-mediated cascade:FGFR4 ⁶⁶ Signaling by FGFR3 in disease ⁶⁶ Signaling by FGFR4 in disease ⁶⁶ Signaling by NTRK2 (TRKB) ⁶⁶	12.81	PIK3CA FGFR3 FGFR2 FGF7 FGF10
3	PI3K-Akt signaling pathway ⁷⁴ Show member pathways Focal adhesion: PI3K-Akt-mTOR-signaling pathway ⁷⁴	12.78	TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
4	Signaling by Receptor Tyrosine Kinases ⁶⁶	12.73	PIK3CA FGFR3 FGFR2 FGF7 FGF10
5	Insulin receptor signalling cascade ⁶⁶ Show member pathways Glucose homeostasis ⁷⁴ IGF1R signaling cascade ⁶⁶ IRS activation ⁶⁶ IRS-mediated signalling ⁶⁶ IRS-related events triggered by IGF1R ⁶⁶ PI3K Cascade ⁶⁶ SHC-related events triggered by IGF1R ⁶⁶ Signal attenuation ⁶⁶ Signaling by Insulin receptor ⁶⁶ Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) ⁶⁶ SOS-mediated signalling ⁶⁶	12.58	PIK3CA FGFR3 FGFR2 FGF7 FGF10
6	Endometrial cancer ⁷⁴ Show member pathways Chromosomal and microsatellite instability in colorectal cancer ⁷⁴ Melanoma ⁷⁴ Non-small cell lung cancer ⁷⁴ Pancreatic adenocarcinoma pathway ⁷⁴ Signal transduction PTEN pathway ²²	12.57	TP53 PIK3CA FGFR3 FGFR2 CDKN2A
7	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ⁶⁶ Show member pathways Constitutive Signaling by Aberrant PI3K in Cancer ⁶⁶ Negative regulation of the PI3K/AKT network ⁶⁶ PI3K/AKT Signaling in Cancer ⁶⁶	12.54	FGF10 FGF7 FGFR2 FGFR3 PIK3CA
8	Overview of interferons-mediated signaling pathway ⁷⁴ Show member pathways all-trans-Retinoic Acid Mediated Apoptosis ⁶⁴ Cytokine Network ⁶⁴ Immune response IFN alpha/beta signaling pathway ²² Interferon alpha/beta signaling ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵ Regulation of IFNA/IFNB signaling ⁶⁶ Type III interferon signaling ⁷⁴	12.44	TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
9	Negative regulation of FGFR1 signaling ⁶⁶ Show member pathways FGFR1 ligand binding and activation ⁶⁶ FGFR1b ligand binding and activation ⁶⁶ FGFR1c and Klotho ligand binding and activation ⁶⁶ FGFR1c ligand binding and activation ⁶⁶ FGFRL1 modulation of FGFR1 signaling ⁶⁶ Negative regulation of FGFR2 signaling ⁶⁶ Negative regulation of FGFR3 signaling ⁶⁶ Negative regulation of FGFR4 signaling ⁶⁶ Signaling by activated point mutants of FGFR1 ⁶⁶ Signaling by FGFR1 ⁶⁶ Signaling by FGFR1 amplification mutants ⁶⁶ Signaling by FGFR3 ⁶⁶ Signaling by FGFR4 ⁶⁶ Spry regulation of FGF signaling ⁶⁶	12.4	PIK3CA FGFR3 FGFR2 FGF7 FGF10
10	NF-kappaB Pathway ⁷⁰ Show member pathways Akt Pathway ⁷⁰ Apoptosis Pathway ⁷⁰	12.34	TP53 PIK3CA FGFR3 FGFR2
11	RhoGDI Pathway ⁶⁴ Show member pathways Fc-GammaR-Mediated Phagocytosis in Macrophages ⁶⁴	12.3	FGFR3 FGFR2 FGF7 FGF10
12	G-protein signaling RAC1 in cellular process ²² Show member pathways CDC42 signaling events ⁶¹ Cytoskeleton remodeling CDC42 in cellular processes ²² RAC1 signaling pathway ⁶¹	12.29	FGF10 FGF7 FGFR2 FGFR3 PIK3CA
13	MAPK signaling pathway ⁷⁴	12.22	TP53 FGFR3 FGFR2 FGF7 FGF10
14	Development FGFR signaling pathway ²² Show member pathways Development FGF-family signaling ²² Development Flt3 signaling ²² FGF Pathway ⁶⁴	12.21	FGF10 FGF7 FGFR2 FGFR3 PIK3CA
15	MAPK Signaling: Mitogens ⁶⁵ Show member pathways Akt Signaling Pathway ⁶⁵	12.12	TP53 PIK3CA FGFR3 FGFR2
16	Malignant pleural mesothelioma ⁷⁴	12.11	TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
17	Breast cancer pathway ⁷⁴ Show member pathways Embryonic stem cell pluripotency pathways ⁷⁴	12.06	TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
18	Signaling by FGFR2 ⁶⁶ Show member pathways FGFR2 ligand binding and activation ⁶⁶ FGFR2b ligand binding and activation ⁶⁶ Signaling by FGFR ⁶⁶	12.04	PIK3CA FGFR3 FGFR2 FGF7 FGF10
19	Signaling by FGFR2 in disease ⁶⁶ Show member pathways FGFR2 mutant receptor activation ⁶⁶ Signaling by FGFR in disease ⁶⁶ Signaling by FGFR2 IIIa TM ⁶⁶	11.92	PIK3CA FGFR3 FGFR2 FGF7 FGF10
20	Regulation of actin cytoskeleton ⁷⁴	11.83	PIK3CA FGFR3 FGFR2 FGF7 FGF10
21	Burn wound healing ⁷⁴	11.66	TP53 FGFR3 FGFR2
22	G-protein signaling_RhoA regulation pathway ²²	11.63	FGFR3 FGFR2 FGF7 FGF10
23	Osteoblast differentiation and related diseases ⁷⁴	11.57	PIK3CA FGFR3 FGFR2
24	Prader-Willi and Angelman syndrome ⁷⁴	11.55	TYR TP53 CDKN2A
25	SHP2 signaling ⁶¹	11.48	PIK3CA FGFR3 FGFR2
26	FGF signaling pathway ⁶¹	11.48	PIK3CA FGFR3 FGFR2
27	Vemurafenib Pathway, Pharmacodynamics ⁶⁰	11.33	FGFR3 FGFR2 FGF7
28	Bladder cancer ⁷⁴	11.29	TP53 FGFR3 CDKN2A
29	Head and neck squamous cell carcinoma ⁷⁴	10.88	TP53 PIK3CA FGFR3 FGFR2 CDKN2A

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GO Terms for Acanthoma

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 21)

#	Name	GO ID	Score	Top Affiliating Genes
1	animal organ morphogenesis	GO:0009887	10.17	FGF10 FGF7 FGFR2 FOXN1
2	hair follicle morphogenesis	GO:0031069	9.97	FGF10 FGF7 FGFR2
3	thymus development	GO:0048538	9.95	TYR FOXN1 FGF10
4	positive regulation of phospholipase activity	GO:0010518	9.9	FGFR3 FGFR2
5	bud elongation involved in lung branching	GO:0060449	9.89	FGFR2 FGF10
6	lacrimal gland development	GO:0032808	9.88	FGFR2 FGF10
7	otic vesicle formation	GO:0030916	9.88	FGFR2 FGF10
8	T cell lineage commitment	GO:0002360	9.84	TP53 FOXN1
9	epithelial cell proliferation involved in salivary gland morphogenesis	GO:0060664	9.83	FGFR2 FGF10
10	positive regulation of epithelial cell proliferation involved in lung morphogenesis	GO:0060501	9.81	FGFR2 FGF7
11	secretion by lung epithelial cell involved in lung growth	GO:0061033	9.78	FGF7 FGF10
12	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	GO:0060665	9.76	FGF7 FGF10
13	fibroblast growth factor receptor signaling pathway	GO:0008543	9.76	FGFR3 FGFR2 FGF7 FGF10
14	epidermis morphogenesis	GO:0048730	9.73	FGFR2 FGF10
15	fibroblast growth factor receptor signaling pathway involved in mammary gland specification	GO:0060595	9.73	FGF10 FGFR2
16	mammary gland bud formation	GO:0060615	9.71	FGF10 FGFR2
17	branch elongation involved in salivary gland morphogenesis	GO:0060667	9.67	FGF10 FGFR2
18	mesenchymal cell differentiation involved in lung development	GO:0060915	9.62	FGF10 FGFR2
19	branching involved in salivary gland morphogenesis	GO:0060445	9.35	FGFR2 FGF7 FGF10
20	epidermis development	GO:0008544	9.28	KRT5 KRT10 FOXN1 FGF7 FGF10
21	cellular response to endogenous stimulus	GO:0071495	9.26	FGFR2 FGFR3

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	type 2 fibroblast growth factor receptor binding	GO:0005111	9.46	FGF7 FGF10
2	fibroblast growth factor receptor activity	GO:0005007	9.26	FGFR3 FGFR2
3	structural constituent of skin epidermis	GO:0030280	9.1	KRT5 KRT10 KRT1

Sources

Sources for Acanthoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ACN010 MIFTS: 39	Acanthoma Categories: Cancer diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Expand all tables