MCID: ACN010
MIFTS: 38

Acanthoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Acanthoma

MalaCards integrated aliases for Acanthoma:

Name: Acanthoma 12 20 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:174
MeSH 44 D049309
NCIt 50 C7419
UMLS 71 C0846967

Summaries for Acanthoma

GARD : 20 An acanthoma is a small, reddish bump that usually develops on the skin of an older adult. There are several types of acanthoma, including "acantholytic", "epidermolytic", "clear cell", and "melanoacanthoma". Though most individuals have only one acanthoma, there have been rare reports of individuals who have developed many. The exact cause of acanthoma is not known; it is sometimes called a benign tumor, and sometimes described as the result of inflammation. Acanthomas are not considered dangerous and do not require treatment, but they may be removed for cosmetic reasons or to relieve any associated symptoms.

MalaCards based summary : Acanthoma is related to clear cell acanthoma and epidermolytic acanthoma. An important gene associated with Acanthoma is FGF7 (Fibroblast Growth Factor 7), and among its related pathways/superpathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Affiliated tissues include skin, ovary and uterus, and related phenotypes are integument and digestive/alimentary

Wikipedia : 74 An acanthoma is a skin neoplasm composed of squamous or epidermal cells. It is located in the prickle... more...

Related Diseases for Acanthoma

Diseases related to Acanthoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 299)
# Related Disease Score Top Affiliating Genes
1 clear cell acanthoma 32.8 KRT10 FGFR2 FGF7 FGF10
2 epidermolytic acanthoma 31.8 TCHH KRT10 KRT1 CDKN2A
3 pilar sheath acanthoma 30.9 TCHH KRT5 CD1E CD1C CD1B CD1A
4 large cell acanthoma 30.7 TP53 TCHH MLANA KRT5 KRT17 KRT10
5 squamous cell papilloma 30.2 TP53 CDKN2A
6 ichthyosis bullosa of siemens 30.1 KRT10 KRT1
7 lichen planus 30.0 TP53 KRT10 KRT1 CD1A
8 nevus, epidermal 29.9 PIK3CA KRT10 KRT1 FGFR3 FGFR2
9 actinic keratosis 29.9 TP53 KRT17 CDKN2A
10 keratoacanthoma 29.9 TP53 KRT17 KRT10 CD1A
11 porokeratosis 29.8 TP53 TCHH KRT1 FGFR3 FGFR2
12 epidermolytic hyperkeratosis 29.8 TCHH KRT5 KRT17 KRT10 KRT1
13 psoriasis 29.6 KRT5 KRT17 KRT10 KRT1 FGF7
14 eccrine acrospiroma 29.6 KRT5 KRT17 KRT10
15 anus cancer 29.6 TP53 PIK3CA CDKN2A
16 papilloma 29.3 TP53 KRT5 KRT10 KRT1 FGFR3 CDKN2A
17 keratosis 29.1 TP53 PIK3CA KRT5 KRT17 KRT10 KRT1
18 in situ carcinoma 28.9 TP53 PIK3CA KRT5 KRT17 CDKN2A
19 basal cell carcinoma 28.7 TP53 TCHH KRT5 KRT17 KRT10 KRT1
20 skin carcinoma 28.1 TP53 PIK3CA MLANA KRT5 KRT17 KRT10
21 skin disease 27.5 TP53 TCHH KRT5 KRT17 KRT10 KRT1
22 keratosis, seborrheic 27.1 TP53 TCHH PIK3CA MLANA KRT5 KRT17
23 acantholytic acanthoma 11.2
24 onychocytic matricoma 11.1
25 erythrokeratoderma ''en cocardes'' 10.4
26 fgfr craniosynostosis syndromes 10.4 FGFR3 FGFR2
27 hemifacial hyperplasia 10.4 FGFR3 FGFR2
28 inverted follicular keratosis 10.4
29 autosomal dominant epidermolytic ichthyosis 10.4
30 plagiocephaly 10.4 FGFR3 FGFR2
31 syndromic craniosynostosis 10.4 FGFR3 FGFR2
32 testicular spermatocytic seminoma 10.4 FGFR3 FGFR2
33 keratinopathic ichthyosis 10.4 KRT10 KRT1
34 hypertelorism, microtia, facial clefting syndrome 10.3 FGFR3 FGFR2
35 posttransplant acute limbic encephalitis 10.3
36 erythroderma, ichthyosiform, congenital reticular 10.3 KRT10 KRT1
37 striate palmoplantar keratoderma 10.3 KRT10 KRT1
38 aplasia of lacrimal and salivary glands 10.3 FGFR2 FGF7 FGF10
39 dacryocystocele 10.3 FGFR3 FGFR2 FGF10
40 chronic inflammation of lacrimal passage 10.3 FGFR3 FGFR2 FGF10
41 breast juvenile papillomatosis 10.3 PIK3CA FGFR3
42 deafness, autosomal recessive 71 10.3 FGFR3 FGFR2 FGF10
43 dermatosis papulosa nigra 10.3 PIK3CA FGFR3
44 muenke syndrome 10.3 FGFR3 FGFR2 FGF10
45 luteoma 10.3 FGFR3 FGFR2
46 jackson-weiss syndrome 10.3 FGFR3 FGFR2 FGF10
47 adult teratoma 10.3 TP53 FGFR2
48 actinic cheilitis 10.3 TP53 FGFR3
49 sarcomatoid transitional cell carcinoma 10.3 TP53 MLANA
50 cholesteatoma of middle ear 10.2 KRT10 FGFR2 FGF7

Graphical network of the top 20 diseases related to Acanthoma:



Diseases related to Acanthoma

Symptoms & Phenotypes for Acanthoma

MGI Mouse Phenotypes related to Acanthoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.9 CDKN2A FGF10 FGF7 FGFR2 FGFR3 KRT1
2 digestive/alimentary MP:0005381 9.8 CDKN2A FGF10 FGFR2 FGFR3 KRT17 KRT5
3 no phenotypic analysis MP:0003012 9.5 CDKN2A FGFR2 FGFR3 KRT17 MLANA PIK3CA
4 pigmentation MP:0001186 9.1 CDKN2A FGFR2 KRT1 KRT17 MLANA TP53

Drugs & Therapeutics for Acanthoma

Search Clinical Trials , NIH Clinical Center for Acanthoma

Genetic Tests for Acanthoma

Anatomical Context for Acanthoma

MalaCards organs/tissues related to Acanthoma:

40
Skin, Ovary, Uterus, Cervix, Colon, Prostate

Publications for Acanthoma

Articles related to Acanthoma:

(show top 50) (show all 435)
# Title Authors PMID Year
1
Hyaline Inclusion Acanthoma. 61
33606370 2021
2
Epidermolytic Acanthoma: Findings of a Large Retrospective Study. 61
33290356 2021
3
Clear cell acanthoma. 61
32989899 2021
4
[A case of nasal vestibule acantholytic acanthoma]. 61
33254352 2020
5
Cutaneous acantholytic dyskeratotic acanthoma accompanying syringofibroadenomatous hyperplasia with proliferation of mature sebocytes: A case report. 61
33300158 2020
6
Development of clear cell acanthoma during adalimumab therapy: Is it a novel paradoxical cutaneous reaction? 61
32951308 2020
7
Clinical value of high-resolution dynamic contrast-enhanced (DCE) MRI in diagnosis of cutaneous squamous cell carcinoma. 61
33141995 2020
8
Epidermolytic acanthoma in a young woman: a case letter. 61
33040803 2020
9
Epidermolytic acanthoma: A case report. 61
33024766 2020
10
Polarizing-specific white lines in a clear cell acanthoma. 61
32885010 2020
11
Clear Cell Acanthoma: A Review of Clinical and Histologic Variants. 61
32854184 2020
12
Multiple porokeratomas (porokeratotic acanthoma) coexisting with disseminated superficial porokeratosis: Clinical, dermoscopic and pathological observations, and review of published work. 61
32415691 2020
13
Pale (Clear) Cell Acanthoma of the Palate. 61
31230231 2020
14
The complexity of clear cell acanthoma diagnosis based on the literature review. 61
32792892 2020
15
Mutations in KRT10 in epidermolytic acanthoma. 61
32045015 2020
16
Differences in dermoscopic findings between early and mature clear cell acanthoma. 61
32180264 2020
17
Successful treatment of acanthoma fissuratum with intralesional triamcinolone acetonide. 61
32274040 2020
18
Dermoscopy of subungual acantholytic dyskeratotic acanthoma. 61
31532837 2020
19
Onychomatricoma Micropapilliferum, a New Variant of Onychomatricoma: Clinical, Dermoscopical, and Histological Correlations (Report of 4 Cases). 61
31436573 2020
20
Multiple Epidermolytic Acanthomas: Rare Vulval Lesions Which May be Mistaken for Viral Warts. 61
30480645 2020
21
Solitary oral epidermolytic acanthoma: Case report of a rarely diagnosed entity. 61
31078506 2019
22
Expression of Connexin 43 (Cx43) in Benign Cutaneous Tumors With Follicular Differentiation. 61
30839347 2019
23
Large Cell Acanthoma of the Conjunctiva: Clinicopathologic and Immunohistochemical Features. 61
31559241 2019
24
Verruciform and Condyloma-like Squamous Proliferations in the Anogenital Region. 61
30203987 2019
25
Pigmented clear cell acanthoma with a string of pearls pattern on dermoscopy: The first case demonstrating visualization. 61
30659646 2019
26
In vivo characterization of large cell acanthoma by cellular resolution optical coherent tomography. 61
30940575 2019
27
Solitary and multiple epidermolytic acanthoma: A demographic and clinical study of 131 cases. 61
30663082 2019
28
Multiple acantholytic dyskeratotic acanthomas in a liver-transplant recipient. 61
31046909 2019
29
Epidermolytic Acanthoma Mimicking Condyloma: A Case Report. 61
31700841 2019
30
Onychocytic matricoma. 61
31090828 2019
31
Onychocytic matricoma. 61
33261798 2019
32
Clear cell acanthoma (CCA)-like lesions of the nipple/areola: A clinicopathological study of 12 cases supporting a nonneoplastic eczematous disease. 61
30558902 2019
33
Image Gallery: Red coral vascular pattern as a new dermoscopic clue for clear cell acanthoma. 61
30604543 2019
34
Clear Cell Acanthoma with Atypical Location -Case Report and Literature Review. 61
31123619 2018
35
Longitudinal subungual acanthoma: one denomination for various clinical presentations. 61
29705997 2018
36
Giant clear cell acanthoma with dermatoscopic white lines. 61
30116672 2018
37
Two cases of large cell acanthoma successfully treated with photodynamic therapy. 61
29633447 2018
38
Clear Cell Acanthoma on the Areola. 61
30261576 2018
39
Dermoscopic features of clear cell acanthoma. 61
29924237 2018
40
Subungual acantholytic dyskeratotic acanthoma: an unusual cause of longitudinal erythronychia. 61
29735169 2018
41
Dermoscopic features of clear cell acanthoma. 61
33288102 2018
42
Multiple Eruptive Clear Cell Acanthoma. 61
29692468 2018
43
Plaque-Like Pilar Sheath Acanthoma: Histopathologic and Immunohistochemical Study of 3 Unusual Cases. 61
28609346 2018
44
Acanthoma planoepitheliale hyperkeratoticum, lesions associated with BRAF inhibitor in metastatic melanoma. 61
28857272 2018
45
Case of podoplanin-positive clear cell acanthoma. 61
28266032 2018
46
Multiple epidermolytic acanthomas mimicking condyloma: a retrospective study of 8 cases. 61
29090469 2018
47
Familial seborrhoeic keratosis associated with multiple 'pure reticulated acanthomas' and infundibulocystic basal cell carcinomas. 61
28627087 2017
48
Acantholytic dyskeratotic acanthoma: a possible skin adverse event of vemurafenib treatment. 61
28426905 2017
49
Case of reticulated acanthoma with sebaceous differentiation with clinicopathological surveillance. 61
28470879 2017
50
Germinotropic Onychocytic Matricoma: A New Histopathologic Subtype of Onychocytic Matricoma in the Light of the Microanatomy of the Normal Nail Unit, With Special Reference to Nail Mesenchyme. 61
28169867 2017

Variations for Acanthoma

Expression for Acanthoma

Search GEO for disease gene expression data for Acanthoma.

Pathways for Acanthoma

Pathways related to Acanthoma according to GeneCards Suite gene sharing:

(show all 40)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TP53 PIK3CA KRT1 FGFR3 FGFR2 FGF7
2
Show member pathways
13.15 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
3
Show member pathways
13.03 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
4
Show member pathways
12.89 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
5
Show member pathways
12.87 TCHH PIK3CA KRT5 KRT17 KRT10 KRT1
6
Show member pathways
12.77 PIK3CA FGFR3 FGFR2 FGF7 FGF10
7 12.68 TP53 FGFR3 FGFR2 FGF7 FGF10
8
Show member pathways
12.65 PIK3CA FGFR3 FGFR2 FGF7 FGF10
9
Show member pathways
12.64 TP53 PIK3CA FGFR2 FGF7 FGF10 CDKN2A
10
Show member pathways
12.59 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
11 12.55 PIK3CA FGFR3 FGFR2 FGF7 FGF10
12
Show member pathways
12.51 TP53 PIK3CA FGFR2 FGF7 FGF10 CDKN2A
13
Show member pathways
12.47 PIK3CA FGFR3 FGFR2 FGF7 FGF10
14 12.46 TP53 PIK3CA FGFR3 CDKN2A
15
Show member pathways
12.43 TP53 PIK3CA FGFR3 FGFR2
16
Show member pathways
12.42 TP53 PIK3CA FGFR3 FGFR2
17 12.42 TP53 PIK3CA FGFR3 FGFR2 FGF7 FGF10
18
Show member pathways
12.39 TCHH KRT5 KRT17 KRT10 KRT1
19
Show member pathways
12.38 TP53 PIK3CA FGFR3 FGFR2
20
Show member pathways
12.33 FGFR3 FGFR2 FGF7 FGF10
21 12.32 FGFR3 FGFR2 FGF7 FGF10
22
Show member pathways
12.32 PIK3CA FGFR3 FGFR2 FGF7 FGF10
23
Show member pathways
12.31 PIK3CA FGFR3 FGFR2 FGF7 FGF10
24
Show member pathways
12.27 PIK3CA FGFR3 FGFR2 FGF7 FGF10
25
Show member pathways
12.17 TP53 FGFR3 FGFR2 FGF7 FGF10
26
Show member pathways
12.16 TP53 PIK3CA FGFR3 FGFR2
27 12.12 CD1E CD1C CD1B CD1A
28
Show member pathways
12.09 PIK3CA FGFR3 FGFR2 FGF7 FGF10
29 11.92 TP53 PIK3CA CDKN2A
30
Show member pathways
11.89 KRT5 KRT17 KRT1
31
Show member pathways
11.85 PIK3CA FGFR3 FGFR2 FGF7 FGF10
32 11.82 CD1E CD1C CD1B CD1A
33 11.74 TP53 KRT5 KRT17
34 11.67 TP53 PIK3CA CDKN2A
35 11.67 TP53 FGFR3 CDKN2A
36 11.66 FGFR3 FGFR2 FGF7 FGF10
37 11.51 TP53 PIK3CA FGFR3 FGFR2
38 11.48 TP53 FGF7 CDKN2A
39 11.38 FGFR3 FGFR2 FGF7
40 11.03 PIK3CA CD1E CD1C CD1B CD1A

GO Terms for Acanthoma

Cellular components related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 KRT10 KRT1 FGF7 FGF10 CD1E CD1C
2 cell surface GO:0009986 9.65 KRT10 FGFR3 FGFR2 FGF10 CD1B
3 intermediate filament GO:0005882 9.26 KRT5 KRT17 KRT10 KRT1
4 cornified envelope GO:0001533 8.8 TCHH KRT10 KRT1

Biological processes related to Acanthoma according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.93 FGFR3 FGFR2 FGF7 FGF10
2 epidermis development GO:0008544 9.83 KRT5 FGF7 FGF10
3 keratinization GO:0031424 9.83 TCHH KRT5 KRT17 KRT10 KRT1
4 lung development GO:0030324 9.82 FGFR2 FGF7 FGF10
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.82 TP53 FGF7 FGF10
6 positive regulation of protein kinase B signaling GO:0051897 9.8 PIK3CA FGFR3 FGFR2 FGF7 FGF10
7 fibroblast growth factor receptor signaling pathway GO:0008543 9.76 FGFR3 FGFR2 FGF7 FGF10
8 positive regulation of epithelial cell proliferation GO:0050679 9.75 FGFR2 FGF7 FGF10
9 cornification GO:0070268 9.72 TCHH KRT5 KRT17 KRT10 KRT1
10 replicative senescence GO:0090399 9.67 TP53 CDKN2A
11 embryonic digestive tract morphogenesis GO:0048557 9.66 FGFR2 FGF10
12 positive regulation of keratinocyte proliferation GO:0010838 9.66 FGF7 FGF10
13 protein heterotetramerization GO:0051290 9.65 KRT10 KRT1
14 positive regulation of keratinocyte migration GO:0051549 9.64 FGF7 FGF10
15 limb bud formation GO:0060174 9.63 FGFR2 FGF10
16 organ growth GO:0035265 9.62 FGFR2 FGF10
17 positive regulation of phospholipase activity GO:0010518 9.62 FGFR3 FGFR2
18 endochondral bone growth GO:0003416 9.61 FGFR3 FGFR2
19 bud elongation involved in lung branching GO:0060449 9.61 FGFR2 FGF10
20 epidermis morphogenesis GO:0048730 9.6 FGFR2 FGF10
21 lacrimal gland development GO:0032808 9.59 FGFR2 FGF10
22 otic vesicle formation GO:0030916 9.58 FGFR2 FGF10
23 epithelial cell proliferation involved in salivary gland morphogenesis GO:0060664 9.57 FGFR2 FGF10
24 positive regulation of epithelial cell proliferation involved in lung morphogenesis GO:0060501 9.56 FGFR2 FGF7
25 hair follicle morphogenesis GO:0031069 9.56 KRT17 FGFR2 FGF7 FGF10
26 secretion by lung epithelial cell involved in lung growth GO:0061033 9.55 FGF7 FGF10
27 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling GO:0060665 9.54 FGF7 FGF10
28 branching involved in salivary gland morphogenesis GO:0060445 9.54 FGFR2 FGF7 FGF10
29 mesenchymal cell differentiation involved in lung development GO:0060915 9.52 FGFR2 FGF10
30 branch elongation involved in salivary gland morphogenesis GO:0060667 9.51 FGFR2 FGF10
31 mammary gland bud formation GO:0060615 9.49 FGFR2 FGF10
32 fibroblast growth factor receptor signaling pathway involved in mammary gland specification GO:0060595 9.48 FGFR2 FGF10
33 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 CD1E CD1C CD1B CD1A
34 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.26 CD1E CD1C CD1B CD1A
35 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.92 CD1E CD1C CD1B CD1A

Molecular functions related to Acanthoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.46 CD1E CD1C CD1B CD1A
2 structural constituent of epidermis GO:0030280 9.4 KRT10 KRT1
3 MDM2/MDM4 family protein binding GO:0097371 9.37 TP53 CDKN2A
4 type 2 fibroblast growth factor receptor binding GO:0005111 9.32 FGF7 FGF10
5 fibroblast growth factor-activated receptor activity GO:0005007 9.26 FGFR3 FGFR2
6 exogenous lipid antigen binding GO:0030884 9.26 CD1E CD1C CD1B CD1A
7 endogenous lipid antigen binding GO:0030883 8.92 CD1E CD1C CD1B CD1A

Sources for Acanthoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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