MCID: ACC003
MIFTS: 24

Accommodative Esotropia

Categories: Neuronal diseases

Aliases & Classifications for Accommodative Esotropia

MalaCards integrated aliases for Accommodative Esotropia:

Name: Accommodative Esotropia 12 15
Esotropia with Accommodative Compensation 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9839
ICD9CM 34 378.35
SNOMED-CT 67 194112008
ICD10 32 H50.43
UMLS 70 C0155336

Summaries for Accommodative Esotropia

MalaCards based summary : Accommodative Esotropia, also known as esotropia with accommodative compensation, is related to suppression amblyopia and esotropia. An important gene associated with Accommodative Esotropia is CHN1 (Chimerin 1). The drugs Benzocaine and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include eye and cortex, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Accommodative Esotropia

Diseases related to Accommodative Esotropia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 45)
# Related Disease Score Top Affiliating Genes
1 suppression amblyopia 31.2 PHOX2A CHN1
2 esotropia 30.9 SALL4 ROBO3 PHOX2A HOXA1 CHN1
3 anisometropia 30.4 TSPAN10 PHOX2A PDE6G CHN1
4 ametropic amblyopia 29.9 PHOX2A CHN1
5 strabismus 29.9 TSPAN10 SALL4 ROBO3 PHOX2A CHN1
6 exotropia 29.8 SALL4 ROBO3 PHOX2A CHN1
7 hypertropia 29.6 ROBO3 PHOX2A CHN1
8 hypotropia 29.0 SALL4 ROBO3 PHOX2A CHN1
9 monocular esotropia 11.2
10 refractive error 10.9
11 amblyopia 10.9
12 mechanical strabismus 10.9
13 farsightedness 10.7
14 alternating exotropia 10.6
15 astigmatism 10.6
16 myopia 10.4
17 pathologic nystagmus 10.3
18 cycloplegia 10.3
19 diabetes mellitus, ketosis-prone 10.2
20 ptosis 10.2
21 abnormal retinal correspondence 10.2
22 movement disease 10.2
23 cataract 10.2
24 hemifacial spasm, familial 10.0
25 polykaryocytosis inducer 10.0
26 brown syndrome 10.0
27 deficiency anemia 10.0
28 weill-marchesani syndrome 10.0
29 brachydactyly 10.0
30 geleophysic dysplasia 10.0
31 irregular astigmatism 10.0
32 central nervous system disease 10.0
33 nervous system disease 10.0
34 47,xyy 10.0
35 head injury 10.0
36 hemifacial spasm 10.0
37 paralytic squint 9.9 PHOX2A CHN1
38 congenital ptosis 9.8 PHOX2A CHN1
39 exudative vitreoretinopathy 5 9.8 TSPAN10 PDE6G ARL16
40 keratitis, hereditary 9.7 PHOX2A KERA
41 partial third-nerve palsy 9.3 SALL4 ROBO3 PHOX2A CHN1
42 duane-radial ray syndrome 9.3 SALL4 ROBO3 PHOX2A CHN1
43 ocular motility disease 9.3 SALL4 ROBO3 PHOX2A CHN1
44 tukel syndrome 9.1 SALL4 ROBO3 PHOX2A HOXA1 CHN1
45 duane retraction syndrome 9.1 SALL4 ROBO3 PHOX2A HOXA1 CHN1

Graphical network of the top 20 diseases related to Accommodative Esotropia:



Diseases related to Accommodative Esotropia

Symptoms & Phenotypes for Accommodative Esotropia

GenomeRNAi Phenotypes related to Accommodative Esotropia according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-111 9.55 CHN1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-12 9.55 PDE6G
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-125 9.55 PDE6G
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 9.55 CHN1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.55 PDE6G
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.55 CHN1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-166 9.55 CHN1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-173 9.55 ARL16
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.55 PDE6G
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-20 9.55 PDE6G
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.55 CHN1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.55 ARL16
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-4 9.55 CHN1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-6 9.55 PDE6G
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.55 ARL16 PDE6G
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-95 9.55 ARL16

Drugs & Therapeutics for Accommodative Esotropia

Drugs for Accommodative Esotropia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
2
tannic acid Approved 1401-55-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Maximal Tolerable Reduction in Hyperopic Correction in Patients With Refractive Accommodative Esotropia: A 6-month Follow-up Study Completed NCT01179711
2 Augmented Medial Rectus Muscle Recession Versus Medial Rectus Recession With Posterior Scleral Fixation in Partially Accommodative Esotropia Completed NCT02413463
3 An Observational Study of Infantile, Acquired Non-accommodative, and Acquired Partially-accommodative Esotropia Completed NCT00310960

Search NIH Clinical Center for Accommodative Esotropia

Genetic Tests for Accommodative Esotropia

Anatomical Context for Accommodative Esotropia

MalaCards organs/tissues related to Accommodative Esotropia:

40
Eye, Cortex

Publications for Accommodative Esotropia

Articles related to Accommodative Esotropia:

(show top 50) (show all 411)
# Title Authors PMID Year
1
Long-term surgical outcomes of preoperative prism adaptation in patients with partially accommodative esotropia. 61
32678351 2021
2
Is hypermetropia regressing in accommodative esotropia? 61
33567009 2021
3
A smartphone ocular alignment measurement app in school screening for strabismus. 61
33765984 2021
4
The Efficacy of Dose Increments of Botulinum Toxin A in the Treatment of Childhood Esotropia. 61
33469257 2021
5
Effect of prism adaptation in patients with partially accommodative esotropia: clinical findings and surgical outcomes. 61
32827083 2021
6
Outcomes of pediatric accommodative esotropia with botulinum toxin A treatment in Thailand. 61
33404269 2021
7
Outcomes in accommodative esotropia with a high AC/A ratio. 61
33356527 2020
8
Outcome of surgery for near angle in patient with incomitant distance/near esotropia and without manifest deviation at distance. 61
33135499 2020
9
Combined passive and active treatment in strabismic amblyopia with accommodative component. 61
32996215 2020
10
Acute comitant esotropia in a very young child due to combined mechanism: A case report. 61
33120711 2020
11
Augmented medial rectus muscle recession versus medial rectus recession with posterior scleral fixation in partially accommodative esotropia: a randomized clinical trial. 61
33038494 2020
12
Refractive change in children with accommodative esotropia. 61
31806647 2020
13
Systemic and ocular manifestations of a patient with mosaic ARID1A-associated Coffin-Siris syndrome and review of select mosaic conditions with ophthalmic manifestations. 61
32888375 2020
14
Changes in Esodeviation after Inferior Oblique Recession in Patients with Refractive Accommodative Esotropia and Inferior Oblique Overaction. 61
32783423 2020
15
Assessment of Refractive Error Changes and Factors for Decompensation in Patients With Fully Accommodative Esotropia. 61
32687205 2020
16
The Role of Heredity and the Prevalence of Strabismus in Families with Accommodative, Partial Accommodative, and Infantile Esotropia 61
32631000 2020
17
Risk factors for spontaneous consecutive exotropia in children with refractive and nonrefractive accommodative esotropia. 61
32108919 2020
18
Long-term refractive outcomes in children with early diagnosis of moderate to high hyperopia. 61
32316817 2020
19
Prism treatment of acute acquired concomitant esotropia precipitated by visual confusion. 61
32301677 2020
20
A Comparative Study of Prism Adaptation and the Augmented Surgery Formula in the Management of Acquired Comitant Esotropia. 61
32203595 2020
21
Esotropia Outcomes and the Influence of Delay to Wearing Full Hypermetropic Correction. 61
32203591 2020
22
Phoria Adaptation: The Ghost in the Machine. 61
31986106 2020
23
Outcome of Esotropia Surgery in 2 Tertiary Hospitals in Cameroon. 61
32103891 2020
24
Botulinum toxin in the treatment of partially accommodative esotropia with high AC/A ratio. 61
32109950 2020
25
Cycloplegia in Children: An Optometrist's Perspective. 61
32904515 2020
26
Post-operative analysis of pediatric esotropia associated with high hypermetropia. 61
31262252 2019
27
Factors influencing stereopsis in patients with both refractive accommodative esotropia and amblyopia. 61
29704131 2019
28
Novel variants in the KERA gene cause autosomal recessive cornea plana in a Chinese family: A case report. 61
31059048 2019
29
Accommodative esotropia and Brown syndrome in a girl with recessive geleophysic dysplasia. 61
30415012 2019
30
The effects of partial and full correction of refractive errors on sensorial and motor outcomes in children with refractive accommodative esotropia. 61
29549487 2019
31
Lateral rectus sag and recurrent esotropia in children. 61
30797977 2019
32
Photorefractive keratectomy influences the angle of ocular deviation in strabismus patients with hyperopia. 61
29502213 2019
33
Accommodative esotropia: the state of the art. 61
29332227 2019
34
Long-term outcomes of prismatic correction in partially accommodative esotropia. 61
31790473 2019
35
Comparison of surgical dose response between divergence insufficiency esotropia and non-accommodative esotropia without divergence insufficiency. 61
31339954 2019
36
Acquired, Comitant, Non-Accommodative Esotropia (ANAET): Evaluation, Treatment, and Prognosis. 61
30806582 2019
37
Changes in axial length in accommodative esotropia patients with minimal hyperopic correction. 61
30682011 2019
38
Esodeviation without correction for tapering hyperopia in refractive accommodative esotropia. 61
30340709 2018
39
Long-term motor and sensory outcomes after surgery for the nonaccommodative component of partially refractive accommodative esotropia. 61
30217512 2018
40
Immediate Postoperative Alignment Following Bimedial Rectus Recession for Esotropia in Children Compared to Adults. 61
29913023 2018
41
Amblyopia in High Accommodative Convergence/Accommodation Ratio Accommodative Esotropia. Influence of Bifocals on Treatment Outcome. 61
29729255 2018
42
Clinical study of the influence of preoperative wearing time on postoperative effects in children with partially accommodative esotropia. 61
29742698 2018
43
Stereoacuity outcomes following surgical correction of the nonaccommodative component in partially accommodative esotropia. 61
29526713 2018
44
The Role of Dynamic Retinoscopy in Predicting Infantile Accommodative Esotropia and Influencing Emmetropization. 61
30196757 2018
45
Accommodative Esotropia Treatment Plan Utilizing Simultaneous Strabismus Surgery and Photorefractive Keratectomy. 61
29339065 2018
46
Anterior Segment Changes during Accommodation in Accommodative Esotropia. 61
29376230 2018
47
Botulinum toxin chemodenervation for childhood strabismus in England: National and local patterns of practice. 61
29902283 2018
48
The prevalence of strabismus types in strabismic Iranian patients. 61
30214338 2018
49
The relationship between abduction deficit and reoperation among patients with infantile esotropia. 61
29600183 2018
50
Long-term development of refractive error in refractive, nonrefractive and partially accommodative esotropia. 61
30248135 2018

Variations for Accommodative Esotropia

Expression for Accommodative Esotropia

Search GEO for disease gene expression data for Accommodative Esotropia.

Pathways for Accommodative Esotropia

GO Terms for Accommodative Esotropia

Sources for Accommodative Esotropia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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