Aliases & Classifications for Acetaminophen Metabolism

MalaCards integrated aliases for Acetaminophen Metabolism:

Name: Acetaminophen Metabolism 57 29 55

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
acetaminophen metabolism:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 100675
MedGen 42 C1863486
SNOMED-CT via HPO 69 263681008 18165001

Summaries for Acetaminophen Metabolism

MalaCards based summary : Acetaminophen Metabolism is related to pericholangitis and mammographic density. An important gene associated with Acetaminophen Metabolism is CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Acetaminophen and Analgesics have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotypes are jaundice and Decreased viability

Description from OMIM: 100675

Related Diseases for Acetaminophen Metabolism

Graphical network of the top 20 diseases related to Acetaminophen Metabolism:



Diseases related to Acetaminophen Metabolism

Symptoms & Phenotypes for Acetaminophen Metabolism

Symptoms via clinical synopsis from OMIM:

57
Skin:
jaundice

Lab:
impaired acetaminophen glucuronidation in gilbert syndrome (143500)


Clinical features from OMIM:

100675

Human phenotypes related to Acetaminophen Metabolism:

32
# Description HPO Frequency HPO Source Accession
1 jaundice 32 HP:0000952

GenomeRNAi Phenotypes related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.53 CYP1A1 CYP2A13 CYP2C19 CYP2D6 NQO1 SULT1A1
2 Decreased viability GR00402-S-2 9.53 CYP1A1 CYP2A13 CYP2C19 CYP2D6 NQO1 SULT1A1

Drugs & Therapeutics for Acetaminophen Metabolism

Drugs for Acetaminophen Metabolism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Not Applicable 103-90-2 1983
2 Analgesics Phase 4,Not Applicable
3 Analgesics, Non-Narcotic Phase 4,Not Applicable
4 Antipyretics Phase 4,Not Applicable
5 Peripheral Nervous System Agents Phase 4,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Race/Ethnicity and Genes on Acetaminophen Pharmacokinetics Completed NCT00768716 Phase 4 Acetaminophen
2 Effect on Acetaminophen Metabolism by Liquid Formulations Completed NCT01246713 Not Applicable Acetaminophen liquid formulation;Acetaminophen solid formulation

Search NIH Clinical Center for Acetaminophen Metabolism

Genetic Tests for Acetaminophen Metabolism

Genetic tests related to Acetaminophen Metabolism:

# Genetic test Affiliating Genes
1 Acetaminophen Metabolism 29

Anatomical Context for Acetaminophen Metabolism

MalaCards organs/tissues related to Acetaminophen Metabolism:

41
Liver

Publications for Acetaminophen Metabolism

Articles related to Acetaminophen Metabolism:

(show all 23)
# Title Authors Year
1
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. ( 26348886 )
2015
2
Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity. ( 25533740 )
2015
3
Acetaminophen metabolism after liver resection: A prospective case-control study. ( 26362614 )
2015
4
PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. ( 26049587 )
2015
5
Mathematical modelling of chronic acetaminophen metabolism and liver injury. ( 23788256 )
2014
6
Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury. ( 23436315 )
2013
7
Application of physiologically based pharmacokinetic modeling to predict acetaminophen metabolism and pharmacokinetics in children. ( 24132164 )
2013
8
Acetaminophen metabolism after major surgery: a greater challenge with increasing age. ( 21975347 )
2011
9
Microsomal oxidative damage promoted by acetaminophen metabolism. ( 21569833 )
2011
10
Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. ( 18093979 )
2008
11
Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse. ( 16611625 )
2006
12
Transiently altered acetaminophen metabolism after liver transplantation. ( 12811364 )
2003
13
Alteration of acetaminophen metabolism by sulfate and steroids in primary monolayer hepatocyte cultures of rats and mice. ( 10220281 )
1999
14
Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. ( 9714300 )
1998
15
Effects of phenethyl isothiocyanate on acetaminophen metabolism and hepatotoxicity in mice. ( 9194414 )
1997
16
Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1. ( 9253715 )
1997
17
The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. ( 9246016 )
1997
18
Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes. ( 8659683 )
1996
19
Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. ( 7956731 )
1994
20
Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes. ( 8466546 )
1993
21
Acetaminophen metabolism in recovering alcoholics. ( 2087153 )
1990
22
In vivo microdialysis sampling coupled to liquid chromatography for the study of acetaminophen metabolism. ( 2376606 )
1990
23
Interaction of ethanol with acetaminophen metabolism in the baboon. ( 6540564 )
1984

Variations for Acetaminophen Metabolism

Expression for Acetaminophen Metabolism

Search GEO for disease gene expression data for Acetaminophen Metabolism.

Pathways for Acetaminophen Metabolism

Pathways related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 43)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.08 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
2
Show member pathways
13.31 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
3
Show member pathways
12.96 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
4 12.69 CYP1A2 CYP2D6 CYP3A4 NQO1 UGT1A1 UGT1A10
5
Show member pathways
12.44 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
6
Show member pathways
12.38 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2E1
7 12.28 CYP2A6 GSTP1 NQO1 UGT1A1 UGT1A3 UGT1A6
8
Show member pathways
12.23 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2D6 CYP2E1
9
Show member pathways
12.08 CYP1A1 CYP1A2 CYP2C19
10
Show member pathways
12.01 CYP1A2 CYP2C19 CYP2E1 CYP3A4
11
Show member pathways
12 CYP2C19 CYP2D6 CYP3A4 UGT1A1 UGT1A3 UGT1A9
12
Show member pathways
11.96 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4 UGT1A3
13
Show member pathways
11.92 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2D6 CYP2E1
14
Show member pathways
11.84 CYP1A1 CYP1A2 CYP2C19 CYP2D6 CYP3A4 UGT1A1
15
Show member pathways
11.78 CYP3A4 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
16
Show member pathways
11.73 CYP1A1 CYP1A2 CYP2A13 CYP2C19 CYP3A4
17
Show member pathways
11.7 CYP1A2 CYP2A6 CYP2C19 CYP2D6 CYP2E1 CYP3A4
18 11.68 CYP1A1 CYP1A2 NQO1 UGT1A1 UGT1A3 UGT1A6
19
Show member pathways
11.67 CYP1A1 CYP1A2 CYP2E1 CYP3A4 UGT1A1 UGT1A10
20 11.55 CYP1A2 CYP2C19 CYP3A4
21 11.52 CYP1A1 CYP1A2 NQO1
22 11.49 CYP1A1 CYP1A2 CYP2C19 CYP2D6
23
Show member pathways
11.41 CYP2D6 CYP3A4 UGT1A1
24 11.37 CYP1A2 CYP2E1 CYP3A4
25
Show member pathways
11.37 CYP1A1 CYP1A2 CYP3A4 UGT1A1 UGT1A9 UGT2B15
26 11.35 CYP1A1 CYP1A2 CYP2A6 CYP2E1 CYP3A4 GSTP1
27
Show member pathways
11.34 CYP1A2 CYP2A6 CYP2E1 CYP3A4
28 11.32 CYP1A1 NQO1 UGT1A6
29 11.28 CYP2A6 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
30 11.18 CYP1A2 CYP2A13 CYP3A4
31 11.15 GSTP1 NQO1
32
Show member pathways
11.14 CYP1A1 CYP1A2 CYP3A4 NQO1 SULT1A1 UGT1A1
33 11.11 CYP2A6 CYP2E1 CYP3A4
34 11.06 GSTP1 NQO1
35
Show member pathways
11.01 CYP2A13 CYP2A6 UGT1A9
36 10.98 CYP3A4 GSTP1 UGT1A1
37 10.94 CYP2D6 UGT1A3 UGT1A9
38 10.8 CYP1A1 CYP1A2
39 10.79 CYP2A6 UGT1A3
40 10.73 CYP2A6 CYP2C19 CYP3A4 SULT1A1 UGT1A1 UGT1A3
41
Show member pathways
10.72 CYP2A6 CYP2E1
42 10.45 CYP2E1 NQO1
43 10.36 CYP3A4 UGT1A1

GO Terms for Acetaminophen Metabolism

Cellular components related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endoplasmic reticulum membrane GO:0005789 9.8 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
2 organelle membrane GO:0031090 9.28 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
3 membrane GO:0016020 10.17 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
4 endoplasmic reticulum GO:0005783 10.07 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
5 intracellular membrane-bounded organelle GO:0043231 10 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6

Biological processes related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.97 CYP1A1 CYP1A2 CYP2E1 UGT1A1
2 steroid metabolic process GO:0008202 9.96 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2D6 CYP2E1
3 response to organic cyclic compound GO:0014070 9.91 CYP1A1 CYP1A2 NQO1 UGT1A1
4 epoxygenase P450 pathway GO:0019373 9.91 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2E1
5 response to ethanol GO:0045471 9.9 CYP2E1 GSTP1 NQO1 UGT1A1
6 organic acid metabolic process GO:0006082 9.89 CYP2A13 CYP2A6 CYP2C19 CYP2D6 CYP2E1
7 xenobiotic glucuronidation GO:0052697 9.88 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
8 response to toxic substance GO:0009636 9.85 CYP1A1 GSTP1 NQO1
9 flavonoid glucuronidation GO:0052696 9.85 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
10 cellular glucuronidation GO:0052695 9.85 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
11 response to estradiol GO:0032355 9.84 CYP1A2 GSTP1 NQO1
12 response to organic substance GO:0010033 9.83 CYP1A1 CYP1A2 UGT1A1
13 coumarin metabolic process GO:0009804 9.81 CYP1A1 CYP2A13 CYP2A6 CYP2D6
14 monoterpenoid metabolic process GO:0016098 9.8 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4
15 retinoic acid metabolic process GO:0042573 9.76 UGT1A1 UGT1A3 UGT1A9
16 drug metabolic process GO:0017144 9.76 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2D6 CYP2E1
17 oxidative demethylation GO:0070989 9.75 CYP1A2 CYP2D6 CYP3A4
18 omega-hydroxylase P450 pathway GO:0097267 9.74 CYP1A1 CYP1A2 CYP2C19
19 drug catabolic process GO:0042737 9.72 CYP1A2 CYP2D6 CYP3A4
20 flavone metabolic process GO:0051552 9.71 UGT1A1 UGT1A10 UGT1A9
21 cellular response to copper ion GO:0071280 9.68 CYP1A1 CYP1A2
22 cellular response to glucocorticoid stimulus GO:0071385 9.68 GSTP1 UGT1A1
23 response to immobilization stress GO:0035902 9.68 CYP1A1 CYP1A2
24 vitamin D metabolic process GO:0042359 9.67 CYP1A1 CYP3A4
25 estrogen metabolic process GO:0008210 9.65 SULT1A1 UGT1A1
26 toxin metabolic process GO:0009404 9.65 CYP1A1 CYP1A2
27 amine metabolic process GO:0009308 9.65 CYP1A1 SULT1A1
28 hydrogen peroxide biosynthetic process GO:0050665 9.64 CYP1A1 CYP1A2
29 lipid hydroxylation GO:0002933 9.64 CYP1A1 CYP3A4
30 flavonoid metabolic process GO:0009812 9.63 CYP1A1 SULT1A1
31 steroid catabolic process GO:0006706 9.63 CYP1A2 CYP3A4
32 porphyrin-containing compound metabolic process GO:0006778 9.62 CYP1A1 CYP1A2
33 dibenzo-p-dioxin metabolic process GO:0018894 9.62 CYP1A1 CYP1A2
34 alkaloid catabolic process GO:0009822 9.61 CYP2D6 CYP3A4
35 alkaloid metabolic process GO:0009820 9.59 CYP1A2 CYP2D6
36 heterocycle metabolic process GO:0046483 9.5 CYP1A1 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4
37 exogenous drug catabolic process GO:0042738 9.17 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6 CYP2E1
38 oxidation-reduction process GO:0055114 10.18 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
39 xenobiotic metabolic process GO:0006805 10.13 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6 CYP2E1
40 metabolic process GO:0008152 10.1 GSTP1 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9

Molecular functions related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 monooxygenase activity GO:0004497 9.97 CYP1A1 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4
2 transferase activity, transferring hexosyl groups GO:0016758 9.95 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
3 glucuronosyltransferase activity GO:0015020 9.91 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
4 retinoic acid binding GO:0001972 9.85 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
5 aromatase activity GO:0070330 9.84 CYP1A1 CYP1A2 CYP2A13 CYP2D6
6 arachidonic acid epoxygenase activity GO:0008392 9.83 CYP2A13 CYP2A6 CYP2C19 CYP2E1
7 UDP-glycosyltransferase activity GO:0008194 9.8 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
8 oxygen binding GO:0019825 9.8 CYP1A1 CYP1A2 CYP2A13 CYP2C19 CYP2D6 CYP2E1
9 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.76 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
10 estrogen 16-alpha-hydroxylase activity GO:0101020 9.6 CYP1A1 CYP3A4
11 demethylase activity GO:0032451 9.59 CYP1A1 CYP1A2
12 caffeine oxidase activity GO:0034875 9.58 CYP1A2 CYP3A4
13 vitamin D 24-hydroxylase activity GO:0070576 9.58 CYP1A1 CYP3A4
14 coumarin 7-hydroxylase activity GO:0008389 9.57 CYP2A13 CYP2A6
15 steroid hydroxylase activity GO:0008395 9.5 CYP1A1 CYP2A13 CYP2A6 CYP2C19 CYP2D6 CYP2E1
16 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.23 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
17 transferase activity GO:0016740 10.21 GSTP1 SULT1A1 UGT1A1 UGT1A10 UGT1A3 UGT1A6
18 oxidoreductase activity GO:0016491 10.16 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
19 enzyme binding GO:0019899 10.09 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2E1 CYP3A4
20 iron ion binding GO:0005506 10.06 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
21 transferase activity, transferring glycosyl groups GO:0016757 10.03 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
22 protein homodimerization activity GO:0042803 10.02 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
23 protein heterodimerization activity GO:0046982 10.01 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
24 heme binding GO:0020037 10.01 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6

Sources for Acetaminophen Metabolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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