MCID: ACT149
MIFTS: 37

Acetaminophen Metabolism

Categories: Metabolic diseases, Nephrological diseases

Aliases & Classifications for Acetaminophen Metabolism

MalaCards integrated aliases for Acetaminophen Metabolism:

Name: Acetaminophen Metabolism 57 54

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant


HPO:

31
acetaminophen metabolism:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 100675
MedGen 41 C1863486
SNOMED-CT via HPO 68 18165001 263681008

Summaries for Acetaminophen Metabolism

OMIM® : 57 Acetaminophen (paracetamol) is extensively conjugated with glucuronic acid and sulfate before renal excretion. A minor metabolic route involves microsomal oxidation of acetaminophen to a hepatotoxic reactive intermediate, which subsequently undergoes glutathione (GSH) conjugation, yielding cysteine and mercapturate conjugates, both of which are excreted in the urine (Slattery et al., 1987). (100675) (Updated 20-May-2021)

MalaCards based summary : Acetaminophen Metabolism is related to alcohol use disorder and gilbert syndrome. An important gene associated with Acetaminophen Metabolism is CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Acetaminophen and Analgesics, Non-Narcotic have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and tongue, and related phenotypes are jaundice and Decreased viability

Related Diseases for Acetaminophen Metabolism

Diseases related to Acetaminophen Metabolism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 53)
# Related Disease Score Top Affiliating Genes
1 alcohol use disorder 30.0 CYP3A4 CYP2E1 CYP2C19
2 gilbert syndrome 27.3 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
3 angiodysplasia of intestine 10.3 CYP3A4 CYP1A2
4 mixed epithelial stromal tumour 10.3 CYP3A4 CYP1A2
5 conidiobolomycosis 10.3 CYP3A4 CYP2D6
6 female stress incontinence 10.3 CYP2D6 CYP1A2
7 inhibited female orgasm 10.3 CYP3A4 CYP2C19
8 esophageal candidiasis 10.2 CYP3A4 CYP2C19
9 gastrojejunal ulcer 10.2 CYP3A4 CYP1A2
10 halothane hepatitis 10.2 CYP2E1 CYP2A6
11 toxic oil syndrome 10.2 CYP2D6 CYP1A1
12 outlet dysfunction constipation 10.2 CYP3A4 CYP2D6 CYP2C19
13 neonatal abstinence syndrome 10.2 CYP3A4 CYP2D6
14 porphyria cutanea tarda 10.2 CYP2E1 CYP1A2 CYP1A1
15 liver benign neoplasm 10.2 GSTP1 CYP2E1 CYP1A1
16 cardia cancer 10.1 GSTP1 CYP2E1 CYP1A1
17 substance abuse 10.1 CYP2E1 CYP2D6 CYP2C19
18 mucormycosis 10.1 CYP3A4 CYP2C19
19 polyneuropathy due to drug 10.1 GSTP1 CYP2E1
20 tardive dyskinesia 10.1 NQO1 CYP2D6 CYP1A2
21 danubian endemic familial nephropathy 10.1 SULT1A1 CYP1A2 CYP1A1
22 multiple chemical sensitivity 10.1 GSTP1 CYP2D6 CYP2C19
23 clopidogrel resistance 10.1 CYP3A4 CYP2C19 CYP1A2 CYP1A1
24 hypertrophy of tongue papillae 10.1 CYP3A4 CYP2D6 CYP2C19 CYP1A2
25 severe cutaneous adverse reaction 10.0 CYP3A4 CYP2D6 CYP2C19 CYP1A2
26 substance dependence 10.0 GSTP1 CYP2D6 CYP2A6
27 serotonin syndrome 10.0 CYP3A4 CYP2D6
28 pericholangitis 10.0 UGT1A3 UGT1A10
29 anxiety 10.0 CYP3A4 CYP2D6 CYP2C19 CYP1A2
30 childhood acute lymphocytic leukemia 10.0 NQO1 GSTP1 CYP2E1 CYP1A1
31 major depressive disorder 9.9 CYP3A4 CYP2D6 CYP2C19 CYP1A2
32 coumarin resistance 9.9 CYP3A4 CYP2D6 CYP2C19 CYP2A6 CYP1A2
33 tobacco addiction 9.9 GSTP1 CYP2E1 CYP2A6 CYP1A2 CYP1A1
34 cardiomyopathy, dilated, with hypergonadotropic hypogonadism 9.9 UGT1A6 UGT1A1
35 thiopurines, poor metabolism of, 1 9.9 UGT1A6 UGT1A1 CYP2D6
36 hepatocellular adenoma 9.9 NQO1 GSTP1 CYP3A4 CYP1A2 CYP1A1
37 glucosephosphate dehydrogenase deficiency 9.8 UGT1A6 UGT1A1 CYP2D6
38 duodenal ulcer 9.8
39 liver disease 9.8
40 paracetamol poisoning 9.8
41 acute liver failure 9.8
42 aplastic anemia 9.8 NQO1 GSTP1 CYP3A4 CYP2E1 CYP1A1
43 cholelithiasis 9.7 UGT1A6 UGT1A3 UGT1A1
44 drug-induced hepatitis 9.7 UGT1A3 UGT1A1 CYP2E1 CYP2D6 CYP2C19
45 liver cirrhosis 9.6 GSTP1 CYP3A4 CYP2E1 CYP2D6 CYP2A6 CYP1A2
46 sickle cell anemia 9.4 UGT1A6 UGT1A10 UGT1A1
47 kernicterus 9.1 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
48 bilirubin, serum level of, quantitative trait locus 1 9.1 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
49 crigler-najjar syndrome, type ii 9.1 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
50 hyperbilirubinemia, transient familial neonatal 9.1 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1

Graphical network of the top 20 diseases related to Acetaminophen Metabolism:



Diseases related to Acetaminophen Metabolism

Symptoms & Phenotypes for Acetaminophen Metabolism

Human phenotypes related to Acetaminophen Metabolism:

31
# Description HPO Frequency HPO Source Accession
1 jaundice 31 HP:0000952

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Skin:
jaundice

Lab:
impaired acetaminophen glucuronidation in gilbert syndrome (143500)

Clinical features from OMIM®:

100675 (Updated 20-May-2021)

GenomeRNAi Phenotypes related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00249-S 9.47 NQO1 UGT1A3
2 Decreased viability GR00381-A-1 9.47 CYP1A1 CYP2A13 CYP2C19 CYP2D6 NQO1 SULT1A1
3 Decreased viability GR00386-A-1 9.47 CYP1A1 NQO1
4 Decreased viability GR00402-S-2 9.47 CYP2D6 UGT1A9

Drugs & Therapeutics for Acetaminophen Metabolism

Drugs for Acetaminophen Metabolism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved 103-90-2 1983
2 Analgesics, Non-Narcotic
3 Analgesics
4 Antipyretics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect on Acetaminophen Metabolism by Liquid Formulations: Do Excipients in Liquid Formulation Prevent Production of Toxic Metabolites? Completed NCT01246713 Acetaminophen liquid formulation;Acetaminophen solid formulation

Search NIH Clinical Center for Acetaminophen Metabolism

Genetic Tests for Acetaminophen Metabolism

Anatomical Context for Acetaminophen Metabolism

MalaCards organs/tissues related to Acetaminophen Metabolism:

40
Liver, Endothelial, Tongue

Publications for Acetaminophen Metabolism

Articles related to Acetaminophen Metabolism:

(show top 50) (show all 110)
# Title Authors PMID Year
1
Variability of acetaminophen metabolism in Caucasians and Orientals. 61 57
1302042 1992
2
Dose-dependent pharmacokinetics of acetaminophen: evidence of glutathione depletion in humans. 57
3829578 1987
3
Phenytoin as a possible cause of acetaminophen hepatotoxicity: case report and review of the literature. 54 61
10678302 2000
4
Acetaminophen metabolism revisited using non-targeted analyses: Implications for human biomonitoring. 61
33524668 2021
5
Role of Non-coding RNA in Acetaminophen-induced Liver Injury. 61
33757622 2021
6
Acetaminophen Modulates the Expression of Steroidogenesis-Associated Genes and Estradiol Levels in Human Placental JEG-3 Cells. 61
33098425 2021
7
Determination of acetaminophen and its main metabolites in urine by capillary electrophoresis hyphenated to mass spectrometry. 61
31450387 2019
8
A computational model for hepatotoxicity by coupling drug transport and acetaminophen metabolism equations. 61
31254976 2019
9
Ontogeny of Hepatic Sulfotransferases and Prediction of Age-Dependent Fractional Contribution of Sulfation in Acetaminophen Metabolism. 61
31101678 2019
10
Type of endothelial cells affects HepaRG cell acetaminophen metabolism in both 2D and 3D porous scaffold cultures. 61
30307041 2019
11
Acute Liver Failure Induced by Joss Paper Ingestion. 61
31633080 2019
12
A Systematic Review of the Evidence Behind Use of Reduced Doses of Acetaminophen in Chronic Liver Disease. 61
31206302 2018
13
Genetic Association of Single Nucleotide Polymorphisms with Acetaminophen-Induced Hepatotoxicity. 61
30076262 2018
14
Polymorphic Expression of UGT1A9 is Associated with Variable Acetaminophen Glucuronidation in Neonates: A Population Pharmacokinetic and Pharmacogenetic Study. 61
29654492 2018
15
Acetaminophen-induced Acute Liver Failure Is More Common and More Severe in Women. 61
29199145 2018
16
A Model Mechanism-Based Explanation of an In Vitro-In Vivo Disconnect for Improving Extrapolation and Translation. 61
29434053 2018
17
Antcin H Protects Against Acute Liver Injury Through Disruption of the Interaction of c-Jun-N-Terminal Kinase with Mitochondria. 61
27596680 2017
18
Acetaminophen metabolism after liver resection: A prospective case-control study. 61
26362614 2015
19
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. 61
26348886 2015
20
PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. 61
26049587 2015
21
Effect of orally administered cisapride, bethanechol, and erythromycin on the apparent efficiency of colostral IgG absorption in neonatal Holstein-Friesian calves. 61
25641234 2015
22
The role of intestinal microbiota in murine models of acetaminophen-induced hepatotoxicity. 61
25244648 2015
23
Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity. 61
25533740 2015
24
Comparison of the effects of clonidine, loperamide and metoclopramide in two models of gastric emptying in the rat. 61
24920467 2015
25
Modeling the effects of commonly used drugs on human metabolism. 61
25345908 2015
26
Comparison of Bile Acids and Acetaminophen Protein Adducts in Children and Adolescents with Acetaminophen Toxicity. 61
26208104 2015
27
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices. 61
24949552 2014
28
Mathematical modelling of chronic acetaminophen metabolism and liver injury. 61
23788256 2014
29
Population pharmacokinetics of intravenous acetaminophen and its metabolites in major surgical patients. 61
24846170 2014
30
Application of physiologically based pharmacokinetic modeling to predict acetaminophen metabolism and pharmacokinetics in children. 61
24132164 2013
31
Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury. 61
23436315 2013
32
Regulatory review of acetaminophen clinical pharmacology in young pediatric patients. 61
23073837 2012
33
The dual role of osteopontin in acetaminophen hepatotoxicity. 61
22728710 2012
34
Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole. 61
22048645 2012
35
Acetaminophen metabolism after major surgery: a greater challenge with increasing age. 61
21975347 2011
36
Microsomal oxidative damage promoted by acetaminophen metabolism. 61
21569833 2011
37
Acute interstitial nephritis with acetaminophen and alcohol intoxication. 61
21496243 2011
38
Childhood asthma and use during pregnancy of acetaminophen. A critical review. 61
20933592 2010
39
Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen. 61
20211479 2010
40
Potential role of caveolin-1 in acetaminophen-induced hepatotoxicity. 61
20100502 2010
41
Glutathione reductase is inhibited by acetaminophen-glutathione conjugate in vitro. 61
19537930 2010
42
Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. 61
18093979 2008
43
Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse. 61
16611625 2006
44
Disruption of NaS1 sulfate transport function in mice leads to enhanced acetaminophen-induced hepatotoxicity. 61
16729303 2006
45
Drug interactions in dentistry: the importance of knowing your CYPs. 61
15058617 2004
46
Transiently altered acetaminophen metabolism after liver transplantation. 61
12811364 2003
47
Modulation of acetaminophen-induced hepatotoxicity by the xenobiotic receptor CAR. 61
12376703 2002
48
[Alcohol-paracetamol syndrome: a case report]. 61
12184014 2002
49
Effect of long-term multiple nifedipine administration on the antinociceptive activity of acetaminophen. 61
11957744 2001
50
Growth and metabolic activity of immortalized porcine hepatocytes in extracorporeal hollow-fiber liver assist devices. 61
11493274 2001

Variations for Acetaminophen Metabolism

Expression for Acetaminophen Metabolism

Search GEO for disease gene expression data for Acetaminophen Metabolism.

Pathways for Acetaminophen Metabolism

Pathways related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 48)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.12 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
2
Show member pathways
12.87 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
3
Show member pathways
12.79 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
4 12.69 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1 NQO1
5
Show member pathways
12.37 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
6
Show member pathways
12.31 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
7 12.3 UGT1A9 UGT1A6 UGT1A3 UGT1A1 NQO1 GSTP1
8
Show member pathways
12.18 UGT1A9 UGT1A3 UGT1A1 GSTP1 CYP3A4 CYP2D6
9
Show member pathways
12.15 UGT1A3 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP1A2
10
Show member pathways
12.09 CYP2C19 CYP1A2 CYP1A1
11 12.06 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
12
Show member pathways
12.04 CYP3A4 CYP2E1 CYP2C19 CYP1A2
13
Show member pathways
12.01 CYP3A4 CYP2E1 CYP2A13 CYP1A2 CYP1A1
14
Show member pathways
11.93 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
15
Show member pathways
11.93 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
16
Show member pathways
11.9 SULT1A1 CYP2C19 CYP2A6 CYP1A2
17
Show member pathways
11.87 UGT1A9 UGT1A6 UGT1A1 NQO1 CYP3A4 CYP2E1
18
Show member pathways
11.83 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1 CYP3A4
19
Show member pathways
11.78 UGT2B15 UGT1A9 UGT1A3 UGT1A10 UGT1A1 CYP3A4
20
Show member pathways
11.75 CYP3A4 CYP2C19 CYP2A13 CYP1A2 CYP1A1
21 11.72 UGT1A9 UGT1A6 UGT1A3 UGT1A1 NQO1 CYP1A2
22
Show member pathways
11.67 UGT1A1 CYP3A4 CYP2D6 CYP1A1
23
Show member pathways
11.62 UGT1A9 UGT1A6 UGT1A3 UGT1A1 SULT1A1 NQO1
24
Show member pathways
11.59 UGT2B15 UGT1A3 UGT1A10 SULT1A1 CYP3A4 CYP2E1
25 11.57 CYP3A4 CYP2C19 CYP1A2
26
Show member pathways
11.57 UGT2B15 UGT1A9 UGT1A1 CYP3A4 CYP2D6 CYP1A2
27 11.56 UGT1A9 UGT1A6 UGT1A3 UGT1A1 SULT1A1 CYP3A4
28 11.54 NQO1 CYP1A2 CYP1A1
29
Show member pathways
11.53 UGT1A1 CYP3A4 CYP2D6 CYP2C19 CYP1A2 CYP1A1
30 11.52 CYP2D6 CYP2C19 CYP1A2 CYP1A1
31
Show member pathways
11.42 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
32 11.4 CYP3A4 CYP2E1 CYP1A2
33
Show member pathways
11.37 CYP3A4 CYP2E1 CYP2A6 CYP1A2
34 11.37 GSTP1 CYP3A4 CYP2E1 CYP2A6 CYP1A2 CYP1A1
35 11.35 UGT1A6 NQO1 CYP1A1
36 11.21 CYP3A4 CYP2A13 CYP1A2
37 11.15 CYP3A4 CYP2E1 CYP2A6
38
Show member pathways
11.14 CYP3A4 CYP2D6 CYP1A2 CYP1A1
39 11.1 UGT1A9 UGT1A3 CYP2D6 CYP2C19
40 11.06 NQO1 GSTP1
41 11.01 UGT1A3 CYP2D6 CYP2A6
42 11.01 UGT1A1 GSTP1 CYP3A4
43
Show member pathways
11 UGT1A3 CYP2A6
44
Show member pathways
10.96 UGT1A3 UGT1A1 CYP3A4 CYP2D6
45 10.87 UGT1A9 UGT1A10 CYP2D6 CYP1A2
46 10.81 CYP1A2 CYP1A1
47
Show member pathways
10.73 CYP2E1 CYP2A6
48 10.47 NQO1 CYP2E1

GO Terms for Acetaminophen Metabolism

Cellular components related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.2 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
2 intracellular membrane-bounded organelle GO:0043231 10 UGT2B15 UGT1A6 UGT1A1 CYP3A4 CYP2E1 CYP2D6
3 endoplasmic reticulum GO:0005783 10 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
4 organelle membrane GO:0031090 9.56 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6 CYP2A13
5 endoplasmic reticulum membrane GO:0005789 9.47 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1

Biological processes related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 48)
# Name GO ID Score Top Affiliating Genes
1 oxidation-reduction process GO:0055114 10.2 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
2 lipid metabolic process GO:0006629 10.16 UGT2B15 SULT1A1 CYP3A4 CYP2E1 CYP2D6 CYP2C19
3 xenobiotic metabolic process GO:0006805 10.13 UGT2B15 UGT1A9 UGT1A6 SULT1A1 NQO1 GSTP1
4 steroid metabolic process GO:0008202 10.07 SULT1A1 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6
5 fatty acid metabolic process GO:0006631 10.04 CYP1A1 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4
6 response to drug GO:0042493 10.03 UGT1A1 NQO1 CYP2E1 CYP1A2 CYP1A1
7 response to organic cyclic compound GO:0014070 9.94 UGT1A1 NQO1 CYP1A2 CYP1A1
8 response to ethanol GO:0045471 9.94 UGT1A1 NQO1 GSTP1 CYP2E1
9 response to organic substance GO:0010033 9.92 UGT1A1 NQO1 CYP1A2 CYP1A1
10 long-chain fatty acid biosynthetic process GO:0042759 9.92 CYP1A1 CYP1A2 CYP2D6 CYP2E1 CYP3A4
11 retinol metabolic process GO:0042572 9.91 CYP1A1 CYP1A2 CYP2D6 CYP3A4
12 organic acid metabolic process GO:0006082 9.91 CYP2E1 CYP2D6 CYP2C19 CYP2A6 CYP2A13
13 epoxygenase P450 pathway GO:0019373 9.91 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2E1
14 xenobiotic glucuronidation GO:0052697 9.89 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
15 retinoic acid metabolic process GO:0042573 9.88 UGT1A9 UGT1A3 UGT1A1 CYP3A4
16 flavonoid glucuronidation GO:0052696 9.88 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
17 cellular glucuronidation GO:0052695 9.88 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
18 response to estradiol GO:0032355 9.87 NQO1 GSTP1 CYP1A2
19 cholesterol metabolic process GO:0008203 9.87 CYP1A2 CYP2D6 CYP3A4
20 response to toxic substance GO:0009636 9.86 CYP1A1 GSTP1 NQO1
21 monoterpenoid metabolic process GO:0016098 9.85 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4
22 coumarin metabolic process GO:0009804 9.84 CYP2D6 CYP2A6 CYP2A13 CYP1A1
23 heterocycle metabolic process GO:0046483 9.8 UGT1A1 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP1A2
24 oxidative demethylation GO:0070989 9.79 CYP1A2 CYP2D6 CYP3A4
25 omega-hydroxylase P450 pathway GO:0097267 9.79 CYP1A1 CYP1A2 CYP2C19
26 lipid hydroxylation GO:0002933 9.77 CYP1A1 CYP2E1 CYP3A4
27 flavone metabolic process GO:0051552 9.77 UGT1A9 UGT1A10 UGT1A1
28 drug catabolic process GO:0042737 9.76 CYP3A4 CYP2D6 CYP1A2
29 cellular response to copper ion GO:0071280 9.7 CYP1A2 CYP1A1
30 response to immobilization stress GO:0035902 9.7 CYP1A2 CYP1A1
31 cellular response to glucocorticoid stimulus GO:0071385 9.7 GSTP1 UGT1A1
32 exogenous drug catabolic process GO:0042738 9.7 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6 CYP2A13
33 vitamin D metabolic process GO:0042359 9.69 CYP3A4 CYP1A1
34 response to xenobiotic stimulus GO:0009410 9.69 NQO1 CYP1A1
35 amine metabolic process GO:0009308 9.68 SULT1A1 CYP1A1
36 toxin metabolic process GO:0009404 9.68 CYP1A1 CYP1A2
37 hydrogen peroxide biosynthetic process GO:0050665 9.68 CYP1A1 CYP1A2
38 negative regulation of fatty acid metabolic process GO:0045922 9.67 UGT1A1 UGT1A10
39 flavonoid metabolic process GO:0009812 9.67 SULT1A1 CYP1A1
40 porphyrin-containing compound metabolic process GO:0006778 9.67 CYP1A2 CYP1A1
41 steroid catabolic process GO:0006706 9.66 CYP3A4 CYP1A2
42 negative regulation of glucuronosyltransferase activity GO:1904224 9.66 UGT1A10 UGT1A1
43 alkaloid catabolic process GO:0009822 9.65 CYP3A4 CYP2D6
44 dibenzo-p-dioxin metabolic process GO:0018894 9.65 CYP1A1 CYP1A2
45 negative regulation of cellular glucuronidation GO:2001030 9.65 UGT1A1 UGT1A10
46 alkaloid metabolic process GO:0009820 9.63 CYP2D6 CYP1A2
47 drug metabolic process GO:0017144 9.56 UGT1A1 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6
48 estrogen metabolic process GO:0008210 9.23 UGT2B15 UGT1A3 UGT1A1 SULT1A1 CYP3A4 CYP2D6

Molecular functions related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 transferase activity GO:0016740 10.21 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
2 oxidoreductase activity GO:0016491 10.16 NQO1 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6
3 heme binding GO:0020037 10.08 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6 CYP2A13
4 iron ion binding GO:0005506 10.03 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6 CYP2A13
5 transferase activity, transferring glycosyl groups GO:0016757 10.02 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
6 protein homodimerization activity GO:0042803 10.01 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
7 protein heterodimerization activity GO:0046982 9.98 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
8 glucuronosyltransferase activity GO:0015020 9.97 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
9 retinoic acid binding GO:0001972 9.93 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
10 monooxygenase activity GO:0004497 9.92 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6 CYP2A13
11 enzyme binding GO:0019899 9.9 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2E1 CYP3A4
12 aromatase activity GO:0070330 9.88 CYP3A4 CYP2E1 CYP2C19 CYP2A13 CYP1A2 CYP1A1
13 oxygen binding GO:0019825 9.86 CYP3A4 CYP2E1 CYP2C19 CYP1A1
14 UDP-glycosyltransferase activity GO:0008194 9.85 UGT2B15 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
15 arachidonic acid epoxygenase activity GO:0008392 9.83 CYP2E1 CYP2C19 CYP2A6 CYP2A13
16 steroid hydroxylase activity GO:0008395 9.8 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6 CYP2A13
17 estrogen 16-alpha-hydroxylase activity GO:0101020 9.74 CYP3A4 CYP1A2 CYP1A1
18 estrogen 2-hydroxylase activity GO:0101021 9.71 CYP3A4 CYP1A2 CYP1A1
19 demethylase activity GO:0032451 9.6 CYP1A2 CYP1A1
20 caffeine oxidase activity GO:0034875 9.59 CYP3A4 CYP1A2
21 vitamin D 24-hydroxylase activity GO:0070576 9.58 CYP3A4 CYP1A1
22 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.56 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
23 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.23 CYP3A4 CYP2E1 CYP2D6 CYP2C19 CYP2A6 CYP2A13

Sources for Acetaminophen Metabolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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