MCID: ACT149
MIFTS: 41

Acetaminophen Metabolism

Categories: Metabolic diseases

Aliases & Classifications for Acetaminophen Metabolism

MalaCards integrated aliases for Acetaminophen Metabolism:

Name: Acetaminophen Metabolism 57 29 55

Characteristics:

OMIM:

57
Inheritance:
autosomal dominant


HPO:

32
acetaminophen metabolism:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM 57 100675
MedGen 42 C1863486
SNOMED-CT via HPO 69 263681008 18165001

Summaries for Acetaminophen Metabolism

MalaCards based summary : Acetaminophen Metabolism is related to amelogenesis imperfecta, type ib and danubian endemic familial nephropathy. An important gene associated with Acetaminophen Metabolism is CYP3A4 (Cytochrome P450 Family 3 Subfamily A Member 4), and among its related pathways/superpathways are Metabolism and Cytochrome P450 - arranged by substrate type. The drugs Acetaminophen and Peripheral Nervous System Agents have been mentioned in the context of this disorder. Affiliated tissues include liver, endothelial and colon, and related phenotypes are jaundice and Decreased shRNA abundance (Z-score < -2)

Description from OMIM: 100675

Related Diseases for Acetaminophen Metabolism

Diseases related to Acetaminophen Metabolism via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 27)
# Related Disease Score Top Affiliating Genes
1 amelogenesis imperfecta, type ib 10.2 CYP2D6 CYP1A2
2 danubian endemic familial nephropathy 10.2 CYP1A2 CYP1A1
3 conjunctival degeneration 10.2 CYP2E1 CYP1A1
4 female stress incontinence 10.2 CYP2D6 CYP1A2
5 halothane hepatitis 10.1 CYP2E1 CYP2A6
6 esophageal candidiasis 10.1 CYP3A4 CYP2C19
7 antidepressant or antipsychotic toxicity or dose selection 10.1 CYP2D6 CYP2C19
8 toxic oil syndrome 10.1 CYP2D6 CYP1A1
9 multiple chemical sensitivity 10.1 CYP2D6 CYP2C19
10 descending colon cancer 10.1 UGT1A6 UGT1A1
11 kleptomania 10.0 CYP3A4 CYP2C19 CYP1A2
12 hepatocellular adenoma 10.0 GSTP1 CYP3A4 CYP1A2 CYP1A1
13 crigler-najjar syndrome, type i 10.0 UGT1A9 UGT1A6 UGT1A1
14 pericholangitis 10.0 UGT1A3 UGT1A10
15 kernicterus 10.0 UGT1A9 UGT1A6 UGT1A1
16 dihydropyrimidine dehydrogenase deficiency 10.0 UGT1A6 UGT1A1
17 tardive dyskinesia 10.0 NQO1 CYP2D6 CYP1A2
18 clopidogrel resistance 10.0 CYP3A4 CYP2C19 CYP1A2 CYP1A1
19 anxiety 9.9 CYP1A2 CYP3A4 CYP2D6 CYP2C19
20 pigmentation disease 9.9 UGT1A6 UGT1A1
21 metabolic acidosis 9.8
22 hypoxia 9.8
23 drug-induced hepatitis 9.7 UGT1A3 CYP2E1 CYP2D6 CYP2C19
24 bilirubin, serum level of, quantitative trait locus 1 9.6 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
25 crigler-najjar syndrome, type ii 9.6 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
26 leber congenital amaurosis 4 9.6 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1
27 gilbert syndrome 9.6 UGT1A9 UGT1A6 UGT1A3 UGT1A10 UGT1A1

Graphical network of the top 20 diseases related to Acetaminophen Metabolism:



Diseases related to Acetaminophen Metabolism

Symptoms & Phenotypes for Acetaminophen Metabolism

Symptoms via clinical synopsis from OMIM:

57
Skin:
jaundice

Lab:
impaired acetaminophen glucuronidation in gilbert syndrome (143500)


Clinical features from OMIM:

100675

Human phenotypes related to Acetaminophen Metabolism:

32
# Description HPO Frequency HPO Source Accession
1 jaundice 32 HP:0000952

GenomeRNAi Phenotypes related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

26 (show all 15)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.86 GSTP1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-104 9.86 CYP2A13 CYP3A4 GSTP1 NQO1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-153 9.86 CYP3A4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.86 CYP3A4
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.86 GSTP1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.86 CYP3A4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-212 9.86 CYP3A4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.86 GSTP1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-26 9.86 CYP2A13
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.86 CYP2A13
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.86 CYP2A13
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.86 NQO1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-71 9.86 NQO1
14 Decreased viability GR00381-A-1 9.53 CYP1A1 CYP2A13 CYP2C19 CYP2D6 NQO1 SULT1A1
15 Decreased viability GR00402-S-2 9.53 CYP1A1 CYP2A13 CYP2C19 CYP2D6 NQO1 SULT1A1

Drugs & Therapeutics for Acetaminophen Metabolism

Drugs for Acetaminophen Metabolism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetaminophen Approved Phase 4,Not Applicable 103-90-2 1983
2 Peripheral Nervous System Agents Phase 4,Not Applicable
3 Analgesics Phase 4,Not Applicable
4 Antipyretics Phase 4,Not Applicable
5 Analgesics, Non-Narcotic Phase 4,Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Race/Ethnicity and Genes on Acetaminophen Pharmacokinetics Completed NCT00768716 Phase 4 Acetaminophen
2 Effect on Acetaminophen Metabolism by Liquid Formulations Completed NCT01246713 Not Applicable Acetaminophen liquid formulation;Acetaminophen solid formulation

Search NIH Clinical Center for Acetaminophen Metabolism

Genetic Tests for Acetaminophen Metabolism

Genetic tests related to Acetaminophen Metabolism:

# Genetic test Affiliating Genes
1 Acetaminophen Metabolism 29

Anatomical Context for Acetaminophen Metabolism

MalaCards organs/tissues related to Acetaminophen Metabolism:

41
Liver, Endothelial, Colon

Publications for Acetaminophen Metabolism

Articles related to Acetaminophen Metabolism:

(show all 48)
# Title Authors Year
1
Type of endothelial cells affects HepaRG cell acetaminophen metabolism in both 2D and 3D porous scaffold cultures. ( 30307041 )
2018
2
Timescale analysis of a mathematical model of acetaminophen metabolism and toxicity. ( 26348886 )
2015
3
Metabolic phenotyping applied to pre-clinical and clinical studies of acetaminophen metabolism and hepatotoxicity. ( 25533740 )
2015
4
PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. ( 26049587 )
2015
5
Acetaminophen metabolism after liver resection: A prospective case-control study. ( 26362614 )
2015
6
Mathematical modelling of chronic acetaminophen metabolism and liver injury. ( 23788256 )
2014
7
Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury. ( 23436315 )
2013
8
Application of physiologically based pharmacokinetic modeling to predict acetaminophen metabolism and pharmacokinetics in children. ( 24132164 )
2013
9
Acetaminophen metabolism after major surgery: a greater challenge with increasing age. ( 21975347 )
2011
10
Microsomal oxidative damage promoted by acetaminophen metabolism. ( 21569833 )
2011
11
Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice. ( 18093979 )
2008
12
Acetaminophen metabolism does not contribute to gender difference in its hepatotoxicity in mouse. ( 16611625 )
2006
13
Transiently altered acetaminophen metabolism after liver transplantation. ( 12811364 )
2003
14
Alteration of acetaminophen metabolism by sulfate and steroids in primary monolayer hepatocyte cultures of rats and mice. ( 10220281 )
1999
15
Role of CYP2A5 and 2G1 in acetaminophen metabolism and toxicity in the olfactory mucosa of the Cyp1a2(-/-) mouse. ( 9714300 )
1998
16
Effects of phenethyl isothiocyanate on acetaminophen metabolism and hepatotoxicity in mice. ( 9194414 )
1997
17
Acetaminophen metabolism and cytotoxicity in PC12 cells transfected with cytochrome P4502E1. ( 9253715 )
1997
18
The effect of omeprazole pretreatment on acetaminophen metabolism in rapid and slow metabolizers of S-mephenytoin. ( 9246016 )
1997
19
Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes. ( 8659683 )
1996
20
Effects of flavonoids on cytochrome P450-dependent acetaminophen metabolism in rats and human liver microsomes. ( 7956731 )
1994
21
Zonation of acetaminophen metabolism and cytochrome P450 2E1-mediated toxicity studied in isolated periportal and perivenous hepatocytes. ( 8466546 )
1993
22
Utilizing urinary metabolite data in studying the variability of acetaminophen metabolism. ( 8485587 )
1993
23
Variability of acetaminophen metabolism in Caucasians and Orientals. ( 1302042 )
1992
24
Changes in conjugative enzyme activity and acetaminophen metabolism in young and senescent male F-344 rats following prolonged exposure to buthionine sulfoximine. ( 1521595 )
1992
25
Phenacetin and acetaminophen metabolism in the isolated perfused rat liver. Precursor concentration influences the selection of kinetic parameters to assess hypoxic impairment. ( 1676648 )
1991
26
Increased serum sulfate concentrations in man due to environmental factors: effects on acetaminophen metabolism. ( 1746133 )
1991
27
Effect of chronic hypoxia on acetaminophen metabolism in the rat. ( 1872890 )
1991
28
The influence of disulfiram on acetaminophen metabolism in man. ( 2058179 )
1991
29
Acetaminophen metabolism in recovering alcoholics. ( 2087153 )
1990
30
In vivo microdialysis sampling coupled to liquid chromatography for the study of acetaminophen metabolism. ( 2376606 )
1990
31
Acetaminophen metabolism in vivo by pregnant, fetal, and neonatal guinea pigs. ( 2634094 )
1989
32
Acetaminophen metabolism by cytochrome P450 monooxygenases in Parkinson's disease. ( 2774516 )
1989
33
Effect of chronic treatment with cyclosporine and prednisone on acetaminophen metabolism in renal transplant patients. ( 2799927 )
1989
34
Effects of sulfur-amino acid-deficient diets on acetaminophen metabolism and hepatotoxicity in rats. ( 2815088 )
1989
35
Identification of S-(2,5-dihydroxyphenyl)-cysteine and S-(2,5-dihydroxyphenyl)-N-acetyl-cysteine as urinary metabolites of acetaminophen in the mouse. Evidence for p-benzoquinone as a reactive intermediate in acetaminophen metabolism. ( 3203410 )
1988
36
Effects of methionine deficiency and ethanol ingestion on acetaminophen metabolism in mice. ( 3572569 )
1987
37
Effect of acute and chronic cimetidine administration on acetaminophen metabolism in humans. ( 3661511 )
1987
38
Acetaminophen metabolism, cytotoxicity, and genotoxicity in rat primary hepatocyte cultures. ( 3923657 )
1985
39
Acetaminophen metabolism by the perfused rat liver twelve hours after acetaminophen overdose. ( 4052111 )
1985
40
Interaction of ethanol with acetaminophen metabolism in the baboon. ( 6540564 )
1984
41
Interaction of acute ethanol administration with acetaminophen metabolism and toxicity in rats fed alcohol chronically. ( 6385764 )
1984
42
Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways. ( 6705446 )
1984
43
Effects of oral contraceptive steroids on acetaminophen metabolism and elimination. ( 6861437 )
1983
44
Acetaminophen metabolism in subjects fed charcoal-broiled beef. ( 6883912 )
1983
45
Influence of nutritional status on acetaminophen metabolism in man. ( 7085025 )
1982
46
Age- and sex-related differences in acetaminophen metabolism in the rat. ( 7321767 )
1981
47
Evidence for the involvement of N-acetyl-p- quinoneimine in acetaminophen metabolism. ( 526335 )
1979
48
Acetaminophen metabolism in man, as determined by high-resolution liquid chromatography. ( 4850385 )
1974

Variations for Acetaminophen Metabolism

Expression for Acetaminophen Metabolism

Search GEO for disease gene expression data for Acetaminophen Metabolism.

Pathways for Acetaminophen Metabolism

Pathways related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 44)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.1 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
2
Show member pathways
13.31 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
3
Show member pathways
12.97 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
4 12.7 CYP1A2 CYP2D6 CYP3A4 NQO1 UGT1A1 UGT1A10
5
Show member pathways
12.45 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
6
Show member pathways
12.39 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2E1
7 12.28 CYP2A6 GSTP1 NQO1 UGT1A1 UGT1A3 UGT1A6
8
Show member pathways
12.23 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2D6 CYP2E1
9
Show member pathways
12.08 CYP1A1 CYP1A2 CYP2C19
10
Show member pathways
12.02 CYP1A2 CYP2C19 CYP2E1 CYP3A4
11
Show member pathways
12 CYP2C19 CYP2D6 CYP3A4 UGT1A1 UGT1A3 UGT1A9
12
Show member pathways
11.95 CYP1A1 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4
13
Show member pathways
11.92 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4 UGT1A3
14
Show member pathways
11.78 CYP3A4 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
15
Show member pathways
11.76 CYP1A2 CYP2A6 CYP2C19 CYP2D6 CYP2E1 CYP3A4
16
Show member pathways
11.73 CYP1A1 CYP1A2 CYP2A13 CYP2C19 CYP3A4
17 11.68 CYP1A1 CYP1A2 NQO1 UGT1A1 UGT1A3 UGT1A6
18
Show member pathways
11.67 CYP1A1 CYP1A2 CYP2E1 CYP3A4 UGT1A1 UGT1A10
19
Show member pathways
11.65 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2D6 CYP2E1
20 11.56 CYP1A2 CYP2C19 CYP3A4
21 11.52 CYP1A1 CYP1A2 NQO1
22 11.49 CYP1A1 CYP1A2 CYP2C19 CYP2D6
23
Show member pathways
11.42 CYP2D6 CYP3A4 UGT1A1
24 11.38 CYP1A2 CYP2E1 CYP3A4
25
Show member pathways
11.37 CYP1A1 CYP1A2 CYP3A4 UGT1A1 UGT1A9 UGT2B15
26 11.35 CYP1A1 CYP1A2 CYP2A6 CYP2E1 CYP3A4 GSTP1
27
Show member pathways
11.34 CYP1A2 CYP2A6 CYP2E1 CYP3A4
28 11.32 CYP1A1 NQO1 UGT1A6
29 11.28 CYP2A6 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
30 11.18 CYP1A2 CYP2A13 CYP3A4
31 11.16 GSTP1 NQO1
32
Show member pathways
11.14 CYP1A1 CYP1A2 CYP3A4 NQO1 SULT1A1 UGT1A1
33 11.12 CYP2A6 CYP2E1 CYP3A4
34
Show member pathways
11.08 CYP1A1 CYP1A2 CYP2D6 CYP3A4
35 11.07 GSTP1 NQO1
36
Show member pathways
11.02 CYP2A13 CYP2A6 UGT1A9
37 10.99 CYP3A4 GSTP1 UGT1A1
38 10.95 CYP2D6 UGT1A3 UGT1A9
39 10.8 CYP1A1 CYP1A2
40 10.8 CYP2A6 UGT1A3
41 10.73 CYP2A6 CYP2C19 CYP3A4 SULT1A1 UGT1A1 UGT1A3
42
Show member pathways
10.72 CYP2A6 CYP2E1
43 10.45 CYP2E1 NQO1
44 10.37 CYP3A4 UGT1A1

GO Terms for Acetaminophen Metabolism

Cellular components related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular membrane-bounded organelle GO:0043231 9.8 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
2 organelle membrane GO:0031090 9.28 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
3 membrane GO:0016020 10.17 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
4 endoplasmic reticulum GO:0005783 10.07 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
5 endoplasmic reticulum membrane GO:0005789 10 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6

Biological processes related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.97 CYP1A1 CYP1A2 CYP2E1 UGT1A1
2 steroid metabolic process GO:0008202 9.96 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2D6 CYP2E1
3 response to organic cyclic compound GO:0014070 9.91 CYP1A1 CYP1A2 NQO1 UGT1A1
4 organic acid metabolic process GO:0006082 9.91 CYP2A13 CYP2A6 CYP2C19 CYP2D6 CYP2E1
5 response to ethanol GO:0045471 9.9 CYP2E1 GSTP1 NQO1 UGT1A1
6 long-chain fatty acid biosynthetic process GO:0042759 9.89 CYP1A1 CYP1A2 CYP2D6 CYP2E1 CYP3A4
7 xenobiotic glucuronidation GO:0052697 9.88 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
8 epoxygenase P450 pathway GO:0019373 9.88 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2E1
9 response to lipopolysaccharide GO:0032496 9.86 CYP1A1 CYP1A2 UGT1A1
10 response to estradiol GO:0032355 9.85 CYP1A2 GSTP1 NQO1
11 flavonoid glucuronidation GO:0052696 9.85 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
12 cellular glucuronidation GO:0052695 9.85 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
13 response to toxic substance GO:0009636 9.84 CYP1A1 GSTP1 NQO1
14 response to organic substance GO:0010033 9.83 CYP1A1 CYP1A2 UGT1A1
15 coumarin metabolic process GO:0009804 9.83 CYP1A1 CYP2A13 CYP2A6 CYP2D6
16 monoterpenoid metabolic process GO:0016098 9.83 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4
17 retinoic acid metabolic process GO:0042573 9.76 UGT1A1 UGT1A3 UGT1A9
18 drug metabolic process GO:0017144 9.76 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2D6 CYP2E1
19 omega-hydroxylase P450 pathway GO:0097267 9.75 CYP1A1 CYP1A2 CYP2C19
20 oxidative demethylation GO:0070989 9.74 CYP1A2 CYP2D6 CYP3A4
21 drug catabolic process GO:0042737 9.73 CYP1A2 CYP2D6 CYP3A4
22 flavone metabolic process GO:0051552 9.72 UGT1A1 UGT1A10 UGT1A9
23 cellular response to copper ion GO:0071280 9.68 CYP1A1 CYP1A2
24 response to immobilization stress GO:0035902 9.68 CYP1A1 CYP1A2
25 cellular response to glucocorticoid stimulus GO:0071385 9.68 GSTP1 UGT1A1
26 estrogen metabolic process GO:0008210 9.66 SULT1A1 UGT1A1
27 vitamin D metabolic process GO:0042359 9.66 CYP1A1 CYP3A4
28 toxin metabolic process GO:0009404 9.65 CYP1A1 CYP1A2
29 amine metabolic process GO:0009308 9.65 CYP1A1 SULT1A1
30 hydrogen peroxide biosynthetic process GO:0050665 9.64 CYP1A1 CYP1A2
31 flavonoid metabolic process GO:0009812 9.64 CYP1A1 SULT1A1
32 lipid hydroxylation GO:0002933 9.63 CYP1A1 CYP3A4
33 porphyrin-containing compound metabolic process GO:0006778 9.63 CYP1A1 CYP1A2
34 steroid catabolic process GO:0006706 9.62 CYP1A2 CYP3A4
35 dibenzo-p-dioxin metabolic process GO:0018894 9.62 CYP1A1 CYP1A2
36 alkaloid catabolic process GO:0009822 9.61 CYP2D6 CYP3A4
37 alkaloid metabolic process GO:0009820 9.59 CYP1A2 CYP2D6
38 exogenous drug catabolic process GO:0042738 9.5 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6 CYP2E1
39 heterocycle metabolic process GO:0046483 9.17 CYP1A1 CYP1A2 CYP2C19 CYP2D6 CYP2E1 CYP3A4
40 oxidation-reduction process GO:0055114 10.19 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
41 xenobiotic metabolic process GO:0006805 10.13 CYP1A2 CYP2A13 CYP2C19 CYP2D6 NQO1 GSTP1

Molecular functions related to Acetaminophen Metabolism according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 transferase activity, transferring hexosyl groups GO:0016758 9.95 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
2 glucuronosyltransferase activity GO:0015020 9.93 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
3 monooxygenase activity GO:0004497 9.87 CYP1A1 CYP1A2 CYP2A13 CYP2C19 CYP2D6 CYP2E1
4 oxygen binding GO:0019825 9.86 CYP1A1 CYP2C19 CYP2E1 CYP3A4
5 retinoic acid binding GO:0001972 9.85 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
6 aromatase activity GO:0070330 9.83 CYP1A1 CYP1A2 CYP2A13 CYP2D6
7 arachidonic acid epoxygenase activity GO:0008392 9.81 CYP2A13 CYP2A6 CYP2C19 CYP2E1
8 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016705 9.76 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
9 UDP-glycosyltransferase activity GO:0008194 9.73 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
10 steroid binding GO:0005496 9.62 CYP3A4 UGT1A1
11 estrogen 16-alpha-hydroxylase activity GO:0101020 9.6 CYP1A1 CYP3A4
12 demethylase activity GO:0032451 9.59 CYP1A1 CYP1A2
13 caffeine oxidase activity GO:0034875 9.58 CYP1A2 CYP3A4
14 coumarin 7-hydroxylase activity GO:0008389 9.58 CYP2A13 CYP2A6
15 vitamin D 24-hydroxylase activity GO:0070576 9.57 CYP1A1 CYP3A4
16 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen GO:0016712 9.56 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
17 steroid hydroxylase activity GO:0008395 9.17 CYP1A1 CYP2A13 CYP2A6 CYP2C19 CYP2D6 CYP2E1
18 transferase activity GO:0016740 10.21 GSTP1 SULT1A1 UGT1A1 UGT1A10 UGT1A3 UGT1A6
19 oxidoreductase activity GO:0016491 10.15 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
20 enzyme binding GO:0019899 10.08 CYP1A1 CYP1A2 CYP2A6 CYP2C19 CYP2E1 CYP3A4
21 heme binding GO:0020037 10.03 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6
22 protein homodimerization activity GO:0042803 10.02 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
23 transferase activity, transferring glycosyl groups GO:0016757 10.02 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9 UGT2B15
24 protein heterodimerization activity GO:0046982 10.01 UGT1A1 UGT1A10 UGT1A3 UGT1A6 UGT1A9
25 iron ion binding GO:0005506 10.01 CYP1A1 CYP1A2 CYP2A13 CYP2A6 CYP2C19 CYP2D6

Sources for Acetaminophen Metabolism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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