MCID: ACD001
MIFTS: 32

Acidophil Adenoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Acidophil Adenoma

MalaCards integrated aliases for Acidophil Adenoma:

Name: Acidophil Adenoma 12 15 17
Adenoma, Acidophil 43 71
Eosinophil Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5392
MeSH 43 D000239
NCIt 49 C6780
SNOMED-CT 67 21109002
UMLS 71 C0001433

Summaries for Acidophil Adenoma

MalaCards based summary : Acidophil Adenoma, also known as adenoma, acidophil, is related to galactorrhea and pituitary tumors. An important gene associated with Acidophil Adenoma is STH (Saitohin), and among its related pathways/superpathways are Peptide hormone metabolism and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary and t cells, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Acidophil Adenoma

Diseases related to Acidophil Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 galactorrhea 30.3 PRL IGF1
2 pituitary tumors 30.1 SST PRL POMC IGF1
3 acromegaly 29.4 TRH SST PRL POMC INS IGF1
4 hyperprolactinemia 29.2 TRH SST PRL POMC INS IGF1
5 amenorrhea 29.1 TRH PRL POMC INS IGF1
6 meningioma, familial 29.0 SST PRL POMC MGMT IGF1
7 adenoma 28.4 TRH SST PRL POMC MSH6 MGMT
8 bronchial adenomas/carcinoids childhood 10.4 SST POMC
9 fasting hypoglycemia 10.4 POMC IGF1
10 acth-dependent cushing syndrome 10.4 PRL POMC
11 tuberculum sellae meningioma 10.4 PRL POMC
12 sella turcica neoplasm 10.4 PRL POMC
13 chiasmal syndrome 10.4 SST POMC
14 hypothyroidism, congenital, nongoitrous, 4 10.4 PRL POMC
15 abducens nerve disease 10.4 PRL POMC
16 mammographic density 10.4 PRL IGF1
17 secondary adrenal insufficiency 10.4 INS IGF1
18 hypothalamic obesity 10.4 INS IGF1
19 ectopic cushing syndrome 10.4 SST POMC
20 gangliocytoma 10.3 PRL POMC
21 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.3 INS IGF1
22 carcinoid syndrome 10.3 SST IGF1
23 tsh producing pituitary tumor 10.3 SST PRL
24 intracranial hypertension, idiopathic 10.3 POMC IGF1
25 hypoglycemic coma 10.3 POMC INS
26 cranial nerve palsy 10.3 PRL POMC
27 potter's syndrome 10.3 INS IGF1
28 spinocerebellar degeneration 10.3 SST PRL
29 scleredema adultorum 10.3 POMC INS
30 generalized resistance to thyroid hormone 10.3 TRH PRL
31 marasmus 10.3 INS IGF1
32 gigantism 10.3
33 aromatase excess syndrome 10.3 POMC IGF1
34 diabetic encephalopathy 10.3 INS IGF1
35 autonomic nervous system benign neoplasm 10.3 SST POMC
36 fetal macrosomia 10.3 INS IGF1
37 peripheral nervous system benign neoplasm 10.3 SST POMC
38 duodenal somatostatinoma 10.3 SST INS
39 postgastrectomy syndrome 10.3 SST INS
40 van maldergem syndrome 1 10.3 PRL POMC
41 skin tag 10.3 INS IGF1
42 granulosa cell tumor of the ovary 10.3 PRL INS
43 transient refractive change 10.3 SST INS
44 hypothyroidism, central, with testicular enlargement 10.3 TRH PRL
45 melancholia 10.3 PRL POMC
46 paragonimiasis 10.2 STH CTSL
47 diabetes mellitus, insulin-dependent, 20 10.2 INS IGF1
48 euthyroid sick syndrome 10.2 TRH POMC
49 clonorchiasis 10.2 STH CTSL
50 thyroid hormone resistance, selective pituitary 10.2 TRH SST

Graphical network of the top 20 diseases related to Acidophil Adenoma:



Diseases related to Acidophil Adenoma

Symptoms & Phenotypes for Acidophil Adenoma

MGI Mouse Phenotypes related to Acidophil Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.07 IGF1 INS JAG1 LGALS3 MGMT MSH6
2 endocrine/exocrine gland MP:0005379 9.95 IGF1 INS JAG1 MGMT POMC PRL
3 integument MP:0010771 9.87 IGF1 INS JAG1 LGALS3 MSH6 POMC
4 nervous system MP:0003631 9.81 IGF1 INS JAG1 LGALS3 MGMT POMC
5 neoplasm MP:0002006 9.73 IGF1 LGALS3 MGMT MSH6 POMC PRL
6 no phenotypic analysis MP:0003012 9.43 INS JAG1 MGMT POMC SST TRH
7 renal/urinary system MP:0005367 9.1 IGF1 INS JAG1 LGALS3 POMC TRH

Drugs & Therapeutics for Acidophil Adenoma

Drugs for Acidophil Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3 Gastrointestinal Agents Phase 1
4 Hormones Phase 1
5 Antineoplastic Agents, Hormonal Phase 1
6 Antiemetics Phase 1
7 Hormone Antagonists Phase 1
8 glucocorticoids Phase 1
9 BB 1101 Phase 1
10 Anti-Inflammatory Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Acidophil Adenoma

Cochrane evidence based reviews: adenoma, acidophil

Genetic Tests for Acidophil Adenoma

Anatomical Context for Acidophil Adenoma

MalaCards organs/tissues related to Acidophil Adenoma:

40
Pituitary, T Cells

Publications for Acidophil Adenoma

Articles related to Acidophil Adenoma:

(show all 13)
# Title Authors PMID Year
1
Sudden blindness from pituitary apoplexy: a report of two cases. 61
8258474 1993
2
Acromegaly in 14 cats. 61
2401966 1990
3
Functional pituitary acidophil adenoma in a cat with diabetes mellitus and acromegalic features. 61
3018986 1986
4
Pathology of growth hormone-producing tumors of the human pituitary. 61
3303228 1986
5
Growth Hormone-producing Pituitary Adenoma, Elevated Serum Somatomedin C Concentration and Diabetes Mellitus in a Cat. 61
17422532 1985
6
Acidophil adenoma in the pituitary gland of a sheep. 61
6258281 1981
7
Ultrastructural characterization in acidophil adenoma with 2 types of secreting cells. 61
6247415 1980
8
Pathophysiological interpretation of the syndrome of acromegaly (acidophil adenoma of the hypophysis in adults) and of the syndrome of gigantism (acidophil adenoma of the hypophysis in adolescents). 61
233703 1976
9
Unususpected meningioma in a patient with pituitary gigantism. Case report with autopsy findings. 61
1128239 1975
10
Neoplasm to neoplasm metastasis. An acidophil adenoma harbouring metastatic carcinoma: a case report. 61
4322360 1971
11
The Ultrastructure and Histopathology of an Acidophil Adenoma of the Canine Adenohypophysis. 61
29991118 1967
12
Acidophil adenoma of the pituitary gland and other neoplasms in a boxer. 61
4286973 1966
13
Two rate nasopharyngeal lesions: Hodgkin's sarcoma and oncocytoma (acidophil adenoma). 61
13709528 1961

Variations for Acidophil Adenoma

Expression for Acidophil Adenoma

Search GEO for disease gene expression data for Acidophil Adenoma.

Pathways for Acidophil Adenoma

GO Terms for Acidophil Adenoma

Cellular components related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.5 SST PRL POMC LGALS3 INS IGF1
2 extracellular region GO:0005576 9.28 TRH SST PRL POMC LGALS3 JAG1
3 endosome lumen GO:0031904 9.16 PRL INS

Biological processes related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of mitotic nuclear division GO:0045840 9.37 INS IGF1
2 regulation of multicellular organism growth GO:0040014 9.32 PRL IGF1
3 positive regulation of glycolytic process GO:0045821 9.26 INS IGF1
4 myoblast differentiation GO:0045445 9.16 JAG1 IGF1
5 positive regulation of glycogen biosynthetic process GO:0045725 8.96 INS IGF1
6 cell-cell signaling GO:0007267 8.92 TRH SST POMC INS

Molecular functions related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 INS IGF1
2 hormone activity GO:0005179 9.1 TRH SST PRL POMC INS IGF1
3 insulin-like growth factor receptor binding GO:0005159 8.96 INS IGF1

Sources for Acidophil Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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