MCID: ACD001
MIFTS: 29

Acidophil Adenoma

Categories: Cancer diseases, Endocrine diseases, Blood diseases

Aliases & Classifications for Acidophil Adenoma

MalaCards integrated aliases for Acidophil Adenoma:

Name: Acidophil Adenoma 12 15
Adenoma, Acidophil 44 73
Eosinophil Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5392
MeSH 44 D000239
NCIt 50 C6780
SNOMED-CT 68 21109002
UMLS 73 C0001433

Summaries for Acidophil Adenoma

MalaCards based summary : Acidophil Adenoma, also known as adenoma, acidophil, is related to adenoma and acromegaly. An important gene associated with Acidophil Adenoma is SST (Somatostatin), and among its related pathways/superpathways is Peptide hormone metabolism. The drugs Hormones and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary and t cells, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Acidophil Adenoma

Diseases related to Acidophil Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 adenoma 29.2 IGF1 POMC SST
2 acromegaly 28.8 IGF1 POMC SST
3 bronchus adenoma 10.1 POMC SST
4 chiasmal syndrome 10.1 POMC SST
5 pituitary carcinoma 10.1 POMC SST
6 nelson syndrome 10.1 POMC SST
7 gigantism 10.1
8 functioning pituitary adenoma 10.0 POMC SST
9 adrenal cortex disease 10.0 POMC SST
10 adrenal gland disease 10.0 POMC SST
11 ectopic cushing syndrome 10.0 POMC SST
12 pituitary-dependent cushing's disease 10.0 POMC SST
13 adrenal gland hyperfunction 10.0 POMC SST
14 oncocytoma 9.9
15 diabetes mellitus 9.9
16 nasopharyngitis 9.9
17 sarcoma 9.9
18 thyroid carcinoma, familial medullary 9.9 POMC SST
19 empty sella syndrome 9.8 IGF1 POMC
20 sheehan syndrome 9.8 IGF1 POMC
21 hypothyroidism, congenital, nongoitrous, 4 9.8 IGF1 POMC
22 fasting hypoglycemia 9.8 IGF1 POMC
23 central nervous system organ benign neoplasm 9.8 IGF1 POMC
24 thyroid cancer, nonmedullary, 2 9.8 POMC SST
25 persistent fetal circulation syndrome 9.8 IGF1 POMC
26 opiate dependence 9.8 IGF1 POMC
27 pituitary hormone deficiency, combined, 2 9.8 IGF1 POMC
28 hormone producing pituitary cancer 9.7 IGF1 SST
29 pituitary adenoma 1, multiple types 9.7 IGF1 SST
30 thyroid gland disease 9.7 IGF1 POMC
31 small cell cancer of the lung 9.7 POMC SST
32 gonadal disease 9.7 IGF1 POMC
33 hyperandrogenism 9.7 IGF1 POMC
34 carcinoid syndrome 9.7 IGF1 SST
35 hypopituitarism 9.7 IGF1 POMC
36 chronic fatigue syndrome 9.7 IGF1 POMC
37 pheochromocytoma 9.7 POMC SST
38 mccune-albright syndrome 9.6 IGF1 SST
39 overnutrition 9.6 IGF1 POMC
40 fibrous dysplasia 9.6 IGF1 SST
41 short bowel syndrome 9.6 IGF1 SST
42 microvascular complications of diabetes 1 9.6 IGF1 SST
43 anorexia nervosa 9.6 IGF1 POMC
44 hyperinsulinism 9.5 IGF1 SST
45 hyperglycemia 9.4 IGF1 SST
46 prader-willi syndrome 9.3 IGF1 POMC
47 hypothyroidism 9.2 IGF1 POMC
48 pituitary infarct 9.2 IGF1 POMC SST
49 hyperpituitarism 9.2 IGF1 POMC SST
50 endocrine pancreas disease 9.2 IGF1 POMC SST

Graphical network of the top 20 diseases related to Acidophil Adenoma:



Diseases related to Acidophil Adenoma

Symptoms & Phenotypes for Acidophil Adenoma

GenomeRNAi Phenotypes related to Acidophil Adenoma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.88 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.88 IGF1 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.88 IGF1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.88 POMC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.88 IGF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.88 IGF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.88 IGF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.88 IGF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.88 IGF1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.88 IGF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.88 IGF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.88 POMC IGF1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.88 POMC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.88 POMC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.88 POMC
16 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.88 IGF1

Drugs & Therapeutics for Acidophil Adenoma

Drugs for Acidophil Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 2,Phase 1
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3 Antiemetics Phase 1
4 Anti-Inflammatory Agents Phase 1
5 Antineoplastic Agents, Hormonal Phase 1
6 Autonomic Agents Phase 1
7 BB 1101 Phase 1
8 Dexamethasone acetate Phase 1 1177-87-3
9 Gastrointestinal Agents Phase 1
10 glucocorticoids Phase 1
11 HIV Protease Inhibitors Phase 1
12 Hormone Antagonists Phase 1
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
14 Peripheral Nervous System Agents Phase 1
15
protease inhibitors Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
2 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Acidophil Adenoma

Cochrane evidence based reviews: adenoma, acidophil

Genetic Tests for Acidophil Adenoma

Anatomical Context for Acidophil Adenoma

MalaCards organs/tissues related to Acidophil Adenoma:

41
Pituitary, T Cells

Publications for Acidophil Adenoma

Articles related to Acidophil Adenoma:

# Title Authors Year
1
Functional pituitary acidophil adenoma in a cat with diabetes mellitus and acromegalic features. ( 3018986 )
1986
2
Acidophil adenoma in the pituitary gland of a sheep. ( 6258281 )
1981
3
Ultrastructural characterization in acidophil adenoma with 2 types of secreting cells. ( 6247415 )
1980
4
Pathophysiological interpretation of the syndrome of acromegaly (acidophil adenoma of the hypophysis in adults) and of the syndrome of gigantism (acidophil adenoma of the hypophysis in adolescents). ( 233703 )
1976
5
Neoplasm to neoplasm metastasis. An acidophil adenoma harbouring metastatic carcinoma: a case report. ( 4322360 )
1971
6
Acidophil adenoma of the pituitary gland and other neoplasms in a boxer. ( 4286973 )
1966
7
Two rate nasopharyngeal lesions: Hodgkin's sarcoma and oncocytoma (acidophil adenoma). ( 13709528 )
1961

Variations for Acidophil Adenoma

Expression for Acidophil Adenoma

Search GEO for disease gene expression data for Acidophil Adenoma.

Pathways for Acidophil Adenoma

Pathways related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.88 IGF1 POMC

GO Terms for Acidophil Adenoma

Cellular components related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 IGF1 POMC SST

Biological processes related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.26 POMC SST
2 glucose homeostasis GO:0042593 9.16 IGF1 POMC
3 response to heat GO:0009408 8.96 IGF1 SST
4 regulation of signaling receptor activity GO:0010469 8.8 IGF1 POMC SST

Molecular functions related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 IGF1 POMC SST

Sources for Acidophil Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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