MCID: ACD001
MIFTS: 30

Acidophil Adenoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Acidophil Adenoma

MalaCards integrated aliases for Acidophil Adenoma:

Name: Acidophil Adenoma 12 15 17
Adenoma, Acidophil 45 74
Eosinophil Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5392
MeSH 45 D000239
NCIt 51 C6780
SNOMED-CT 69 21109002
UMLS 74 C0001433

Summaries for Acidophil Adenoma

MalaCards based summary : Acidophil Adenoma, also known as adenoma, acidophil, is related to adenoma and acromegaly. An important gene associated with Acidophil Adenoma is SST (Somatostatin), and among its related pathways/superpathways is Peptide hormone metabolism. The drugs Hormones and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, thyroid and pancreas, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Acidophil Adenoma

Diseases related to Acidophil Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.2 IGF1 POMC SST
2 acromegaly 29.7 IGF1 POMC SST
3 pituitary tumors 29.5 IGF1 POMC SST
4 carcinoid syndrome 29.4 IGF1 SST
5 gigantism 10.2
6 oncocytoma 10.1
7 diabetes mellitus 10.1
8 sarcoma 10.1
9 bronchus adenoma 10.0 POMC SST
10 bronchial adenomas/carcinoids childhood 10.0 POMC SST
11 chiasmal syndrome 10.0 POMC SST
12 pituitary carcinoma 10.0 POMC SST
13 pancreatic endocrine carcinoma 10.0 POMC SST
14 nelson syndrome 10.0 POMC SST
15 tsh producing pituitary tumor 10.0 POMC SST
16 functioning pituitary adenoma 10.0 POMC SST
17 ectopic cushing syndrome 10.0 POMC SST
18 adrenal cortex disease 10.0 POMC SST
19 pituitary-dependent cushing's disease 10.0 POMC SST
20 adrenal gland disease 10.0 POMC SST
21 thyroid gland disease 10.0 POMC SST
22 thyroid carcinoma, familial medullary 9.9 POMC SST
23 empty sella syndrome 9.9 IGF1 POMC
24 sheehan syndrome 9.9 IGF1 POMC
25 fasting hypoglycemia 9.9 IGF1 POMC
26 thyroid cancer, nonmedullary, 2 9.9 POMC SST
27 hypothyroidism, congenital, nongoitrous, 4 9.9 IGF1 POMC
28 small cell cancer of the lung 9.9 POMC SST
29 hypothyroidism 9.9 IGF1 POMC
30 opiate dependence 9.9 IGF1 POMC
31 pituitary hormone deficiency, combined, 2 9.9 IGF1 POMC
32 conn's syndrome 9.9 POMC SST
33 hormone producing pituitary cancer 9.9 IGF1 SST
34 hyperandrogenism 9.9 IGF1 POMC
35 hypopituitarism 9.9 IGF1 POMC
36 chronic fatigue syndrome 9.9 IGF1 POMC
37 overnutrition 9.9 IGF1 POMC
38 pituitary adenoma 1, multiple types 9.9 IGF1 SST
39 gonadal disease 9.8 IGF1 POMC
40 endocrine pancreas disease 9.8 IGF1 SST
41 isolated growth hormone deficiency, type ii 9.8 IGF1 SST
42 mccune-albright syndrome 9.8 IGF1 SST
43 fibrous dysplasia 9.8 IGF1 SST
44 short bowel syndrome 9.8 IGF1 SST
45 anorexia nervosa 9.8 IGF1 POMC
46 microvascular complications of diabetes 1 9.8 IGF1 SST
47 insulin-like growth factor i 9.8 IGF1 SST
48 hyperinsulinism 9.8 IGF1 SST
49 breast disease 9.7 IGF1 POMC
50 hyperglycemia 9.7 IGF1 SST

Graphical network of the top 20 diseases related to Acidophil Adenoma:



Diseases related to Acidophil Adenoma

Symptoms & Phenotypes for Acidophil Adenoma

GenomeRNAi Phenotypes related to Acidophil Adenoma according to GeneCards Suite gene sharing:

27 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.88 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.88 IGF1 POMC
3 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.88 IGF1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.88 POMC
5 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.88 IGF1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-161 9.88 IGF1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-163 9.88 IGF1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-164 9.88 IGF1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.88 IGF1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.88 IGF1
11 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.88 IGF1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.88 IGF1 POMC
13 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.88 POMC
14 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.88 POMC
15 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.88 POMC
16 Increased shRNA abundance (Z-score > 2) GR00366-A-99 9.88 IGF1

Drugs & Therapeutics for Acidophil Adenoma

Drugs for Acidophil Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Hormones Phase 2,Phase 1
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
4
protease inhibitors Phase 1
5 Peripheral Nervous System Agents Phase 1
6 Hormone Antagonists Phase 1
7 Antiemetics Phase 1
8 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1
9 Gastrointestinal Agents Phase 1
10 Autonomic Agents Phase 1
11 HIV Protease Inhibitors Phase 1
12 glucocorticoids Phase 1
13 BB 1101 Phase 1
14 Anti-Inflammatory Agents Phase 1
15 Antineoplastic Agents, Hormonal Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
2 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Acidophil Adenoma

Cochrane evidence based reviews: adenoma, acidophil

Genetic Tests for Acidophil Adenoma

Anatomical Context for Acidophil Adenoma

MalaCards organs/tissues related to Acidophil Adenoma:

42
Pituitary, Thyroid, Pancreas, T Cells, Lung, Cortex, Adrenal Gland

Publications for Acidophil Adenoma

Articles related to Acidophil Adenoma:

# Title Authors Year
1
Functional pituitary acidophil adenoma in a cat with diabetes mellitus and acromegalic features. ( 3018986 )
1986
2
Acidophil adenoma in the pituitary gland of a sheep. ( 6258281 )
1981
3
Ultrastructural characterization in acidophil adenoma with 2 types of secreting cells. ( 6247415 )
1980
4
Pathophysiological interpretation of the syndrome of acromegaly (acidophil adenoma of the hypophysis in adults) and of the syndrome of gigantism (acidophil adenoma of the hypophysis in adolescents). ( 233703 )
1976
5
Neoplasm to neoplasm metastasis. An acidophil adenoma harbouring metastatic carcinoma: a case report. ( 4322360 )
1971
6
The Ultrastructure and Histopathology of an Acidophil Adenoma of the Canine Adenohypophysis. ( 29991118 )
1967
7
Acidophil adenoma of the pituitary gland and other neoplasms in a boxer. ( 4286973 )
1966
8
Two rate nasopharyngeal lesions: Hodgkin's sarcoma and oncocytoma (acidophil adenoma). ( 13709528 )
1961

Variations for Acidophil Adenoma

Expression for Acidophil Adenoma

Search GEO for disease gene expression data for Acidophil Adenoma.

Pathways for Acidophil Adenoma

Pathways related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.88 IGF1 POMC

GO Terms for Acidophil Adenoma

Cellular components related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 8.8 IGF1 POMC SST

Biological processes related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.16 POMC SST
2 response to heat GO:0009408 8.96 IGF1 SST
3 regulation of signaling receptor activity GO:0010469 8.8 IGF1 POMC SST

Molecular functions related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 IGF1 POMC SST

Sources for Acidophil Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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