MCID: ACD001
MIFTS: 32

Acidophil Adenoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Acidophil Adenoma

MalaCards integrated aliases for Acidophil Adenoma:

Name: Acidophil Adenoma 12 15 17
Adenoma, Acidophil 44 71
Eosinophil Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5392
MeSH 44 D000239
NCIt 50 C6780
SNOMED-CT 67 21109002
UMLS 71 C0001433

Summaries for Acidophil Adenoma

MalaCards based summary : Acidophil Adenoma, also known as adenoma, acidophil, is related to acromegaly and adenoma. An important gene associated with Acidophil Adenoma is POMC (Proopiomelanocortin), and among its related pathways/superpathways are cAMP signaling pathway and Peptide hormone metabolism. The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include pituitary, and related phenotypes are homeostasis/metabolism and adipose tissue

Related Diseases for Acidophil Adenoma

Diseases related to Acidophil Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 acromegaly 29.5 TRH SST PRL POMC INS IGF1
2 adenoma 28.3 TRH SST PRL POMC MSH6 MGMT
3 tuberculum sellae meningioma 10.3 PRL POMC
4 sella turcica neoplasm 10.3 PRL POMC
5 bronchial adenomas/carcinoids childhood 10.3 SST POMC
6 fasting hypoglycemia 10.3 POMC IGF1
7 galactorrhea 10.3 PRL IGF1
8 abducens nerve disease 10.3 PRL POMC
9 chiasmal syndrome 10.3 SST POMC
10 hypothyroidism, congenital, nongoitrous, 4 10.3 PRL POMC
11 gangliocytoma 10.3 PRL POMC
12 colon neuroendocrine neoplasm 10.3 SST POMC
13 cranial nerve palsy 10.3 PRL POMC
14 intracranial hypertension, idiopathic 10.2 POMC IGF1
15 secondary adrenal insufficiency 10.2 INS IGF1
16 hypothalamic obesity 10.2 INS IGF1
17 scleredema adultorum 10.2 POMC INS
18 carcinoid syndrome 10.2 SST IGF1
19 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.2 INS IGF1
20 van maldergem syndrome 1 10.2 PRL POMC
21 acth deficiency, isolated 10.2 PRL POMC
22 neurotic disorder 10.2 POMC INS
23 potter's syndrome 10.2 INS IGF1
24 marasmus 10.2 INS IGF1
25 diabetic encephalopathy 10.2 INS IGF1
26 generalized resistance to thyroid hormone 10.2 TRH PRL
27 fetal macrosomia 10.2 INS IGF1
28 postgastrectomy syndrome 10.2 SST INS
29 duodenal somatostatinoma 10.2 SST INS
30 lactocele 10.2 TRH PRL
31 somatostatinoma 10.2 SST INS
32 skin tag 10.2 INS IGF1
33 granulosa cell tumor of the ovary 10.2 PRL INS
34 mixed cerebral palsy 10.2 TRH PRL
35 transient refractive change 10.2 SST INS
36 hypothyroidism, central, with testicular enlargement 10.2 TRH PRL
37 dysthymic disorder 10.2 POMC INS
38 decubitus ulcer 10.2 INS IGF1
39 type 1 diabetes mellitus 20 10.2 INS IGF1
40 breast giant fibroadenoma 10.2 PRL MGMT
41 euthyroid sick syndrome 10.2 TRH POMC
42 functional gastric disease 10.2 SST INS
43 esophageal varix 10.2 SST INS
44 gigantism 10.2
45 thyroid gland medullary carcinoma 10.1 SST POMC
46 pancreatic endocrine carcinoma 10.1 SST INS
47 adrenal cortical hypofunction 10.1 POMC INS
48 donohue syndrome 10.1 INS IGF1
49 suppurative thyroiditis 10.1 TRH INS
50 silent myocardial infarction 10.1 TNNI3 INS

Graphical network of the top 20 diseases related to Acidophil Adenoma:



Diseases related to Acidophil Adenoma

Symptoms & Phenotypes for Acidophil Adenoma

MGI Mouse Phenotypes related to Acidophil Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.97 IGF1 INS LGALS3 MGMT MSH6 POMC
2 adipose tissue MP:0005375 9.77 IGF1 INS LGALS3 POMC SST
3 integument MP:0010771 9.73 IGF1 INS LGALS3 MSH6 POMC PRL
4 neoplasm MP:0002006 9.63 IGF1 LGALS3 MGMT MSH6 POMC PRL
5 nervous system MP:0003631 9.56 IGF1 INS LGALS3 MGMT POMC PRL
6 no phenotypic analysis MP:0003012 9.02 INS MGMT POMC SST TRH

Drugs & Therapeutics for Acidophil Adenoma

Drugs for Acidophil Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
3 Anti-Inflammatory Agents Phase 1
4 Hormones Phase 1
5 Gastrointestinal Agents Phase 1
6 Hormone Antagonists Phase 1
7 BB 1101 Phase 1
8 glucocorticoids Phase 1
9 Antineoplastic Agents, Hormonal Phase 1
10 Antiemetics Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Acidophil Adenoma

Cochrane evidence based reviews: adenoma, acidophil

Genetic Tests for Acidophil Adenoma

Anatomical Context for Acidophil Adenoma

MalaCards organs/tissues related to Acidophil Adenoma:

40
Pituitary

Publications for Acidophil Adenoma

Articles related to Acidophil Adenoma:

(show all 13)
# Title Authors PMID Year
1
Sudden blindness from pituitary apoplexy: a report of two cases. 61
8258474 1993
2
Acromegaly in 14 cats. 61
2401966 1990
3
Functional pituitary acidophil adenoma in a cat with diabetes mellitus and acromegalic features. 61
3018986 1986
4
Pathology of growth hormone-producing tumors of the human pituitary. 61
3303228 1986
5
Growth Hormone-producing Pituitary Adenoma, Elevated Serum Somatomedin C Concentration and Diabetes Mellitus in a Cat. 61
17422532 1985
6
Acidophil adenoma in the pituitary gland of a sheep. 61
6258281 1981
7
Ultrastructural characterization in acidophil adenoma with 2 types of secreting cells. 61
6247415 1980
8
Pathophysiological interpretation of the syndrome of acromegaly (acidophil adenoma of the hypophysis in adults) and of the syndrome of gigantism (acidophil adenoma of the hypophysis in adolescents). 61
233703 1976
9
Unususpected meningioma in a patient with pituitary gigantism. Case report with autopsy findings. 61
1128239 1975
10
Neoplasm to neoplasm metastasis. An acidophil adenoma harbouring metastatic carcinoma: a case report. 61
4322360 1971
11
The Ultrastructure and Histopathology of an Acidophil Adenoma of the Canine Adenohypophysis. 61
29991118 1967
12
Acidophil adenoma of the pituitary gland and other neoplasms in a boxer. 61
4286973 1966
13
Two rate nasopharyngeal lesions: Hodgkin's sarcoma and oncocytoma (acidophil adenoma). 61
13709528 1961

Variations for Acidophil Adenoma

Expression for Acidophil Adenoma

Search GEO for disease gene expression data for Acidophil Adenoma.

Pathways for Acidophil Adenoma

GO Terms for Acidophil Adenoma

Cellular components related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.63 SST PRL POMC LGALS3 INS IGF1
2 extracellular region GO:0005576 9.17 TRH SST PRL POMC LGALS3 INS
3 endosome lumen GO:0031904 8.96 PRL INS

Biological processes related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.58 PRL INS IGF1
2 positive regulation of glucose import GO:0046326 9.48 INS IGF1
3 negative regulation of extrinsic apoptotic signaling pathway GO:2001237 9.46 LGALS3 IGF1
4 activation of protein kinase B activity GO:0032148 9.43 INS IGF1
5 positive regulation of mitotic nuclear division GO:0045840 9.37 INS IGF1
6 regulation of multicellular organism growth GO:0040014 9.32 PRL IGF1
7 positive regulation of glycolytic process GO:0045821 9.26 INS IGF1
8 positive regulation of glycogen biosynthetic process GO:0045725 9.16 INS IGF1
9 negative regulation of feeding behavior GO:2000252 8.96 TRH INS
10 cell-cell signaling GO:0007267 8.92 TRH SST POMC INS

Molecular functions related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 insulin receptor binding GO:0005158 9.16 INS IGF1
2 hormone activity GO:0005179 9.1 TRH SST PRL POMC INS IGF1
3 insulin-like growth factor receptor binding GO:0005159 8.96 INS IGF1

Sources for Acidophil Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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