MCID: ACD001
MIFTS: 29

Acidophil Adenoma

Categories: Blood diseases, Cancer diseases, Endocrine diseases

Aliases & Classifications for Acidophil Adenoma

MalaCards integrated aliases for Acidophil Adenoma:

Name: Acidophil Adenoma 12 15 17
Adenoma, Acidophil 44 72
Eosinophil Adenoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5392
MeSH 44 D000239
NCIt 50 C6780
SNOMED-CT 68 21109002
UMLS 72 C0001433

Summaries for Acidophil Adenoma

MalaCards based summary : Acidophil Adenoma, also known as adenoma, acidophil, is related to galactorrhea and amenorrhea. An important gene associated with Acidophil Adenoma is STH (Saitohin), and among its related pathways/superpathways is Glucocorticoid receptor regulatory network. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include pituitary and t cells, and related phenotype is nervous system.

Related Diseases for Acidophil Adenoma

Diseases related to Acidophil Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 102)
# Related Disease Score Top Affiliating Genes
1 galactorrhea 29.8 PRL IGF1
2 amenorrhea 29.5 PRL POMC
3 adenoma 29.3 SST PRL POMC IGF1
4 acromegaly 28.6 SST PRL POMC IGF1
5 pituitary tumors 28.4 SST PRL POMC IGF1
6 gigantism 10.3
7 pseudopapilledema 10.2 JAG1 IGF1
8 withdrawal disorder 10.2 POMC JAG1
9 fasting hypoglycemia 10.1 POMC IGF1
10 adenohypophysitis 10.1 PRL POMC
11 hypothalamic disease 10.1 PRL POMC
12 pseudohypoparathyroidism, type ia 10.1 PRL IGF1
13 oncocytoma 10.1
14 sarcoma 10.1
15 polyneuropathy 10.1
16 hyperglycemia 10.1
17 spindle cell sarcoma 10.1
18 neuropathy 10.1
19 diabetes mellitus 10.1
20 pituitary apoplexy 10.1 PRL POMC
21 tuberculum sellae meningioma 10.0 PRL POMC
22 sella turcica neoplasm 10.0 PRL POMC
23 opiate dependence 10.0 POMC IGF1
24 mammographic density 10.0 PRL IGF1
25 acth-secreting pituitary adenoma 10.0 PRL POMC
26 abducens nerve disease 10.0 PRL POMC
27 diabetes insipidus, neurohypophyseal 10.0 PRL POMC
28 diabetes insipidus 10.0 PRL POMC
29 fibromyalgia 10.0 PRL IGF1
30 premenstrual tension 10.0 PRL POMC
31 chronic fatigue syndrome 10.0 POMC IGF1
32 adrenal rest tumor 10.0 PRL POMC
33 gynecomastia 9.9 PRL POMC
34 overnutrition 9.9 POMC IGF1
35 ocular motor apraxia 9.9
36 anovulation 9.9 PRL IGF1
37 acanthosis nigricans 9.9 PRL IGF1
38 bronchial adenomas/carcinoids childhood 9.9 SST POMC
39 bronchus adenoma 9.9 SST POMC
40 craniopharyngioma 9.9 PRL IGF1
41 hormone producing pituitary cancer 9.9 SST IGF1
42 pancreatic endocrine carcinoma 9.9 SST POMC
43 carcinoid syndrome 9.8 SST IGF1
44 ectopic cushing syndrome 9.8 SST POMC
45 endocrine pancreas disease 9.8 SST IGF1
46 adrenal gland disease 9.8 SST POMC
47 amenorrhea-galactorrhea syndrome 9.8
48 meningioma, radiation-induced 9.8
49 meningioma, familial 9.8
50 spinal meningioma 9.8

Graphical network of the top 20 diseases related to Acidophil Adenoma:



Diseases related to Acidophil Adenoma

Symptoms & Phenotypes for Acidophil Adenoma

MGI Mouse Phenotypes related to Acidophil Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.02 IGF1 JAG1 POMC PRL SST

Drugs & Therapeutics for Acidophil Adenoma

Drugs for Acidophil Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3
3 Hormone Antagonists Phase 1
4 Antiemetics Phase 1
5 Gastrointestinal Agents Phase 1
6 HIV Protease Inhibitors Phase 1
7 Anti-Inflammatory Agents Phase 1
8 glucocorticoids Phase 1
9 Hormones Phase 1
10
protease inhibitors Phase 1
11 Peripheral Nervous System Agents Phase 1
12 Antineoplastic Agents, Hormonal Phase 1
13 BB 1101 Phase 1
14 Autonomic Agents Phase 1
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Acidophil Adenoma

Cochrane evidence based reviews: adenoma, acidophil

Genetic Tests for Acidophil Adenoma

Anatomical Context for Acidophil Adenoma

MalaCards organs/tissues related to Acidophil Adenoma:

41
Pituitary, T Cells

Publications for Acidophil Adenoma

Articles related to Acidophil Adenoma:

(show all 13)
# Title Authors PMID Year
1
Sudden blindness from pituitary apoplexy: a report of two cases. 38
8258474 1993
2
Acromegaly in 14 cats. 38
2401966 1990
3
Functional pituitary acidophil adenoma in a cat with diabetes mellitus and acromegalic features. 38
3018986 1986
4
Pathology of growth hormone-producing tumors of the human pituitary. 38
3303228 1986
5
Growth Hormone-producing Pituitary Adenoma, Elevated Serum Somatomedin C Concentration and Diabetes Mellitus in a Cat. 38
17422532 1985
6
Acidophil adenoma in the pituitary gland of a sheep. 38
6258281 1981
7
Ultrastructural characterization in acidophil adenoma with 2 types of secreting cells. 38
6247415 1980
8
Pathophysiological interpretation of the syndrome of acromegaly (acidophil adenoma of the hypophysis in adults) and of the syndrome of gigantism (acidophil adenoma of the hypophysis in adolescents). 38
233703 1976
9
Unususpected meningioma in a patient with pituitary gigantism. Case report with autopsy findings. 38
1128239 1975
10
Neoplasm to neoplasm metastasis. An acidophil adenoma harbouring metastatic carcinoma: a case report. 38
4322360 1971
11
The Ultrastructure and Histopathology of an Acidophil Adenoma of the Canine Adenohypophysis. 38
29991118 1967
12
Acidophil adenoma of the pituitary gland and other neoplasms in a boxer. 38
4286973 1966
13
Two rate nasopharyngeal lesions: Hodgkin's sarcoma and oncocytoma (acidophil adenoma). 38
13709528 1961

Variations for Acidophil Adenoma

Expression for Acidophil Adenoma

Search GEO for disease gene expression data for Acidophil Adenoma.

Pathways for Acidophil Adenoma

Pathways related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 PRL POMC

GO Terms for Acidophil Adenoma

Cellular components related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.02 SST PRL POMC JAG1 IGF1
2 secretory granule GO:0030141 8.65 POMC

Biological processes related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of osteoblast differentiation GO:0045669 9.26 JAG1 IGF1
2 response to heat GO:0009408 9.16 SST IGF1
3 response to nutrient GO:0007584 9.07 SST
4 positive regulation of epithelial cell proliferation GO:0050679 9.02 IGF1
5 regulation of multicellular organism growth GO:0040014 8.96 PRL IGF1
6 myoblast differentiation GO:0045445 8.62 JAG1 IGF1

Molecular functions related to Acidophil Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.92 SST PRL POMC IGF1

Sources for Acidophil Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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