MCID: ACN001
MIFTS: 49

Acinar Cell Carcinoma

Categories: Cancer diseases, Rare diseases

Aliases & Classifications for Acinar Cell Carcinoma

MalaCards integrated aliases for Acinar Cell Carcinoma:

Name: Acinar Cell Carcinoma 12 15 73
Acinic Cell Carcinoma 12 53
Carcinoma, Acinar Cell 44
Carcinoma Acinar Cell 55
Acinic Cell Tumor 53
Acinar Cell Tumor 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3025
MeSH 44 D018267
NCIt 50 C3768
SNOMED-CT 68 45410002

Summaries for Acinar Cell Carcinoma

Disease Ontology : 12 A carcinoma that has material basis in abnormally proliferating cells, derives from spindle cells and/or derives from giant cells.

MalaCards based summary : Acinar Cell Carcinoma, also known as acinic cell carcinoma, is related to pancreatic acinar cell adenocarcinoma and adenoma. An important gene associated with Acinar Cell Carcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. The drugs Pancrelipase and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, salivary gland and breast, and related phenotypes are Decreased viability in esophageal squamous lineage and Reduced mammosphere formation

Related Diseases for Acinar Cell Carcinoma

Diseases related to Acinar Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 pancreatic acinar cell adenocarcinoma 32.7 AFP BCL10 CHGA
2 adenoma 30.3 CTNNB1 SMAD4 TP53
3 pancreatoblastoma 30.2 AFP CHGA SERPINA1
4 cowden disease 30.1 BRCA2 CHGA SMAD4
5 carcinosarcoma 29.8 CTNNB1 KRT7 TP53
6 pancreas adenocarcinoma 29.6 BRCA2 CTNNB1 SMAD4 TP53
7 hepatocellular carcinoma 28.9 AFP CTNNB1 KRT7 SERPINA1 SMAD4 TP53
8 acinar cell carcinoma of pancreas 12.6
9 panniculitis 10.5
10 adenocarcinoma 10.3
11 papillary carcinoma 10.3
12 pancreatitis 10.3
13 cellular ependymoma 10.2 CHGA TP53
14 synchronous bilateral breast carcinoma 10.2 BRCA2 TP53
15 fibroepithelial basal cell carcinoma 10.2 CHGA TP53
16 familial colorectal cancer type x 10.2 BRCA2 SMAD4
17 atypical follicular adenoma 10.2 CHGA TP53
18 olfactory groove meningioma 10.2 CHGA TP53
19 gastric lymphoma 10.2 BCL10 TP53
20 anterior cranial fossa meningioma 10.2 CHGA TP53
21 pulmonary blastoma 10.2 CHGA TP53
22 mutyh-associated polyposis 10.2 SMAD4 TP53
23 pleomorphic xanthoastrocytoma 10.2 CHGA TP53
24 urethral benign neoplasm 10.2 CHGA SMAD4
25 adult teratoma 10.2 AFP CHGA
26 colloid carcinoma of the pancreas 10.2 BRCA2 SMAD4
27 sclerosing hepatic carcinoma 10.2 AFP CHGA
28 esophagus adenocarcinoma 10.2 SMAD4 TP53
29 cervix small cell carcinoma 10.2 CHGA TP53
30 orofaciodigital syndrome viii 10.2 AFP BCL10
31 liver sarcoma 10.2 AFP CHGA
32 scrotal carcinoma 10.2 AFP TP53
33 malignant teratoma 10.2 AFP TP53
34 gastric cardia carcinoma 10.2 CHGA SMAD4
35 small cell carcinoma of the bladder 10.2 CHGA KRT7
36 mature teratoma 10.2 AFP TP53
37 cerebellar liponeurocytoma 10.2 CHGA TP53
38 malignant spiradenoma 10.2 KRT7 TP53
39 spiradenoma 10.2 KRT7 TP53
40 vulvar intraepithelial neoplasia 10.2 KRT7 TP53
41 pancreatic serous cystadenoma 10.2 CHGA KRT7
42 clear cell adenofibroma 10.2 BRCA2 KRT7
43 peritoneum cancer 10.2 BRCA2 KRT7
44 bladder carcinoma in situ 10.2 KRT7 TP53
45 ampulla of vater adenocarcinoma 10.2 BRCA2 KRT7
46 vulvar disease 10.1 KRT7 TP53
47 papillary serous adenocarcinoma 10.1 KRT7 TP53
48 gastric squamous cell carcinoma 10.1 CHGA KRT7
49 nasal cavity adenocarcinoma 10.1 KRT7 TP53
50 rh isoimmunization 10.1 AFP BCL10

Graphical network of the top 20 diseases related to Acinar Cell Carcinoma:



Diseases related to Acinar Cell Carcinoma

Symptoms & Phenotypes for Acinar Cell Carcinoma

GenomeRNAi Phenotypes related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.56 AFP BCL10 BRCA2 CHGA CTNNB1 KRT7
2 Reduced mammosphere formation GR00396-S 9.1 AFP CHGA ETV6 KRT7 REG1A SMAD4

MGI Mouse Phenotypes related to Acinar Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.91 AFP BCL10 BRCA2 CHGA CTNNB1 ETV6
2 homeostasis/metabolism MP:0005376 9.81 AFP BRCA2 CHGA CTNNB1 ETV6 KRT7
3 embryo MP:0005380 9.8 BCL10 BRCA2 CTNNB1 ETV6 SMAD4 TP53
4 neoplasm MP:0002006 9.43 AFP BRCA2 CTNNB1 ETV6 SMAD4 TP53
5 reproductive system MP:0005389 9.17 AFP BRCA2 CHGA CTNNB1 REG1A SMAD4

Drugs & Therapeutics for Acinar Cell Carcinoma

Drugs for Acinar Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 115)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pancrelipase Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 53608-75-6
2
Gemcitabine Approved Phase 3,Phase 2,Phase 1,Early Phase 1 95058-81-4 60750
3
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1 68538-85-2
4
Fluorouracil Approved Phase 3,Phase 2,Phase 1,Early Phase 1 51-21-8 3385
5
leucovorin Approved Phase 3,Phase 2,Phase 1,Early Phase 1 58-05-9 6006 143
6
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
7
Doxepin Approved, Investigational Phase 3 1668-19-5 667477 667468
8
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
9
Capecitabine Approved, Investigational Phase 3,Phase 2,Early Phase 1 154361-50-9 60953
10
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
11 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
12 Antidotes Phase 3,Phase 2,Phase 1
13 Antiviral Agents Phase 3,Phase 2,Phase 1,Early Phase 1
14 Calcium, Dietary Phase 3,Phase 2,Phase 1
15 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Early Phase 1
16 Vitamin B Complex Phase 3,Phase 2,Phase 1
17 Trace Elements Phase 3,Phase 2,Phase 1
18 Vitamins Phase 3,Phase 2,Phase 1
19 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Early Phase 1
20 Micronutrients Phase 3,Phase 2,Phase 1
21 Antimetabolites Phase 3,Phase 2,Phase 1,Early Phase 1
22 Immunologic Factors Phase 3,Phase 2,Phase 1,Early Phase 1
23 pancreatin Phase 3,Phase 2,Phase 1,Not Applicable
24 Folate Phase 3,Phase 2,Phase 1
25 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Early Phase 1
26 Protective Agents Phase 3,Phase 2,Phase 1
27 Vitamin B9 Phase 3,Phase 2,Phase 1
28 Neurotransmitter Agents Phase 3
29 Histamine Antagonists Phase 3
30 Psychotropic Drugs Phase 3
31 Antidepressive Agents Phase 3
32
Histamine Phosphate Phase 3 51-74-1 65513
33 Antidepressive Agents, Tricyclic Phase 3
34 Cola Phase 3,Early Phase 1
35 Central Nervous System Depressants Phase 3
36 Adjuvants, Anesthesia Phase 3
37 Liver Extracts Phase 3,Phase 1,Early Phase 1
38 Anesthetics, Intravenous Phase 3
39 Analgesics, Opioid Phase 3
40 Peripheral Nervous System Agents Phase 3
41 Anesthetics, General Phase 3
42 Analgesics Phase 3
43 Narcotics Phase 3
44 Anesthetics Phase 3
45 Protein Kinase Inhibitors Phase 3,Phase 2,Phase 1
46 Phosphoramidic acid Phase 2, Phase 3
47
Erlotinib Hydrochloride Phase 3,Phase 1 183319-69-9 176871
48
Oxaliplatin Approved, Investigational Phase 2,Phase 1,Early Phase 1 61825-94-3 43805 6857599 5310940 9887054
49
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
50
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142

Interventional clinical trials:

(show all 47)
# Name Status NCT ID Phase Drugs
1 Two Chemotherapy Regimens Compared With Observation in Treating Patients With Completely Resected Pancreatic Cancer Completed NCT00058201 Phase 3 fluorouracil;gemcitabine hydrochloride;leucovorin calcium
2 Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Completed NCT01156142 Phase 3 doxepin hydrochloride
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Acelarin First Line Randomised Pancreatic Study Recruiting NCT03610100 Phase 2, Phase 3 Acelarin;Gemcitabine
5 Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery Active, not recruiting NCT01013649 Phase 3 Capecitabine;Chemotherapy;Erlotinib Hydrochloride;Fluorouracil;Gemcitabine Hydrochloride
6 Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy Completed NCT01658943 Phase 2 Akt Inhibitor MK2206;Fluorouracil;Oxaliplatin;Selumetinib
7 Carboplatin and Paclitaxel With or Without Viral Therapy in Treating Patients With Recurrent or Metastatic Pancreatic Cancer Completed NCT01280058 Phase 2 Carboplatin;Paclitaxel
8 Bortezomib and Carboplatin in Treating Patients With Metastatic Pancreatic Cancer Completed NCT00416793 Phase 2 bortezomib;carboplatin
9 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine
10 Sunitinib in Treating Patients With Metastatic Pancreatic Cancer That Progressed After First-Line Therapy With Gemcitabine Completed NCT00397787 Phase 2 sunitinib malate
11 Triapine as First-Line or Second-Line Therapy in Treating Patients With Locally Advanced or Metastatic Cancer of the Pancreas Completed NCT00085371 Phase 2 triapine
12 Paclitaxel and Bryostatin 1 in Treating Patients With Advanced Pancreatic Cancer Completed NCT00031694 Phase 2 paclitaxel;bryostatin 1
13 Dasatinib and Gemcitabine Hydrochloride or Gemcitabine Hydrochloride Alone in Treating Patients With Pancreatic Cancer Previously Treated With Surgery Completed NCT01234935 Phase 2 dasatinib;gemcitabine hydrochloride
14 Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers Completed NCT00095563 Phase 2 lapatinib ditosylate
15 Trastuzumab in Treating Patients With Advanced Salivary Gland Cancer Completed NCT00004163 Phase 2 Trastuzumab
16 Cisplatin or Carboplatin Combined With Gemcitabine in Treating Patients With Locally Advanced, Recurrent, or Metastatic Malignant Salivary Gland Tumor Completed NCT00079079 Phase 2 carboplatin;cisplatin;gemcitabine hydrochloride
17 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
18 Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer Recruiting NCT02047474 Phase 2 oxaliplatin;leucovorin calcium;irinotecan hydrochloride;fluorouracil
19 Selinexor, Gemcitabine Hydrochloride, and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Metastatic Pancreatic Cancer Active, not recruiting NCT02178436 Phase 1, Phase 2 gemcitabine hydrochloride;paclitaxel albumin-stabilized nanoparticle formulation;selinexor
20 Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer Active, not recruiting NCT01666730 Phase 2 metformin hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
21 Mitomycin C and Ifosfamide in Treating Patients With Metastatic Pancreatic Cancer Terminated NCT00967291 Phase 2 ifosfamide;mitomycin C
22 Trastuzumab in Treating Patients With Metastatic or Recurrent Salivary Gland Cancer Terminated NCT00126607 Phase 2
23 Title XELOX FOR SALIVARY GLAND CANCERS Terminated NCT00101075 Phase 2 Capecitabine;Oxaliplatin
24 Ultrasound-Guided Photodynamic Therapy With Photofrin & Gemcitabine for Patients With Locally Advanced Pancreatic Cancer Completed NCT01770132 Phase 1 porfimer sodium;gemcitabine hydrochloride
25 CPI-613 in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer Completed NCT01839981 Phase 1 6,8-bis(benzylthio)octanoic acid
26 Sorafenib Tosylate and Everolimus in Treating Patients With Advanced Solid Tumors and Metastatic Pancreatic Cancer That Does Not Respond to Gemcitabine Hydrochloride Completed NCT00981162 Phase 1 sorafenib tosylate;everolimus
27 Vaccine Therapy and Sargramostim in Treating Patients With Pancreas Cancer That Cannot Be Removed By Surgery Active, not recruiting NCT00669734 Phase 1
28 CPI-613 and Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer Active, not recruiting NCT01835041 Phase 1 6,8-bis(benzylthio)octanoic acid;oxaliplatin;leucovorin calcium;irinotecan hydrochloride;fluorouracil
29 GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery Active, not recruiting NCT00878163 Phase 1 Erlotinib Hydrochloride;Gemcitabine Hydrochloride;Vismodegib
30 Alisertib and Gemcitabine Hydrochloride in Treating Patients With Solid Tumors or Pancreatic Cancer Active, not recruiting NCT01924260 Phase 1 alisertib;gemcitabine
31 Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies Active, not recruiting NCT01643499 Phase 1 oxaliplatin;irinotecan hydrochloride;leucovorin calcium;fluorouracil
32 Sirolimus and Vismodegib in Treating Patients With Solid Tumors or Pancreatic Cancer That is Metastatic or Cannot Be Removed By Surgery Suspended NCT01537107 Phase 1 vismodegib;sirolimus
33 Chemoradiation and Radiosurgery Boost in Treating Patients With Locally Advance Pancreatic Cancer That May or May Not be Removed by Surgery Terminated NCT01739439 Phase 1 gemcitabine hydrochloride
34 Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With Metastases to the Liver or Lung Withdrawn NCT01741597 Phase 1
35 MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer Unknown status NCT00984074
36 Chemotherapy and Radiation Therapy Before Surgery Followed by Gemcitabine in Treating Patients With Pancreatic Cancer Completed NCT01821612 Early Phase 1 oxaliplatin;irinotecan;leucovorin;5-fluorouracil;capecitabine;gemcitabine
37 Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer Completed NCT00897793
38 Stereotactic Radiosurgery in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer Completed NCT00851253 Not Applicable
39 Using Traditional Acupuncture in the Management of Cancer Treatment Related Lymphoedema Completed NCT00828516 Not Applicable
40 PET Scans in Patients With Head And Neck Cancer Who Are Undergoing 3-Dimensional Conformal Radiation Therapy And Intensity-Modulated Radiation Therapy Completed NCT00809016 Not Applicable
41 Head & Neck Cancer Survivorship: Physical and Functional Status Completed NCT00751816 systemic chemotherapy
42 Family Quality of Life Among Families With a Member Who is a Cancer Patient Completed NCT00544336
43 Stereotactic Radiosurgery and Metformin in Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer Recruiting NCT02153450 Early Phase 1 metformin hydrochloride
44 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable
45 Incidence of POPF in the Resection of the Left Pancreas With RFAT Recruiting NCT03570502
46 Surgery for Pancreatic Tumors and Collection of Tumor Tissue for Study Terminated NCT00100321
47 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Terminated NCT00499733 Early Phase 1 cyclophosphamide

Search NIH Clinical Center for Acinar Cell Carcinoma

Cochrane evidence based reviews: carcinoma, acinar cell

Genetic Tests for Acinar Cell Carcinoma

Anatomical Context for Acinar Cell Carcinoma

MalaCards organs/tissues related to Acinar Cell Carcinoma:

41
Pancreas, Salivary Gland, Breast, Liver, Lung, Ovary, Pituitary

Publications for Acinar Cell Carcinoma

Articles related to Acinar Cell Carcinoma:

(show top 50) (show all 528)
# Title Authors Year
1
Curative distal pancreatectomy in patients with acinar cell carcinoma of pancreas diagnosed by endoscopic aspiration via esophago-jejunostomy: A successful case report. ( 29331883 )
2018
2
Hepatobiliary and Pancreatic: Primary acinar cell carcinoma of the liver showing good response to chemotherapy. ( 29659083 )
2018
3
BRAF gene rearrangements can be identified by FISH studies in pancreatic acinar cell carcinoma. ( 29506751 )
2018
4
Pancreatic panniculitis as a presentation symptom of acinar cell carcinoma. ( 29527901 )
2018
5
<i>EGFR</i> amplification induces sensitivity to anti<i>EGFR</i> therapy in pancreatic acinar cell carcinoma. ( 29666669 )
2018
6
Surgical resection of hepatic and rectal metastases of pancreatic acinar cell carcinoma (PACC): a case report. ( 30075727 )
2018
7
Pancreatic Acinar Cell Carcinoma with Multiple Liver Metastases Effectively Treated by S-1 Chemotherapy. ( 30101903 )
2018
8
Pancreatic acinar cell carcinoma-induced panniculitis. ( 30128347 )
2018
9
Prevention of pancreatic acinar cell carcinoma by Roux-en-Y Gastric Bypass Surgery. ( 30305629 )
2018
10
Response of germline BRCA2-mutated advanced pancreatic acinar cell carcinoma to olaparib: A case report. ( 30407325 )
2018
11
Pancreatic acinar cell carcinoma-case report and literature review. ( 30409114 )
2018
12
Underutilization of surgical resection in patients with pancreatic acinar cell carcinoma. ( 30514625 )
2018
13
Nomogram to Predict Cancer-Specific Survival in Patients with Pancreatic Acinar Cell Carcinoma: A Competing Risk Analysis. ( 30519311 )
2018
14
Acinic Cell Carcinoma of the Parotid Gland in Children and Adolescents. ( 29240035 )
2018
15
Papillary Pattern in Acinic Cell Carcinoma of Parotid Gland: A Potential Diagnostic Pitfall on FNAC. ( 29403174 )
2018
16
MR imaging features of mammary analogue secretory carcinoma and acinic cell carcinoma of the salivary gland: a preliminary report. ( 29493279 )
2018
17
Central Acinic Cell Carcinoma of the Mandible Simulating as Benign Odontogenic Lesion: A Case Report. ( 29749993 )
2018
18
Synchronous Parotid (Mammary Analog) Secretory Carcinoma and Acinic Cell Carcinoma: Report of a Case. ( 29876739 )
2018
19
Outcomes and prognostic factors for parotid acinic cell Carcinoma: A National Cancer Database study of 2362 cases. ( 29909902 )
2018
20
Four-Year Survival of a Patient With Spinal Metastatic Acinic Cell Carcinoma After a Total En Bloc Spondylectomy and Reconstruction With a Frozen Tumor-Bearing Bone Graft. ( 29913031 )
2018
21
Close Margins and Adjuvant Radiotherapy in Acinic Cell Carcinoma of the Parotid Gland. ( 29978180 )
2018
22
Acinic cell carcinoma of the parotid gland in pregnancy: an approach to cancer in pregnancy. ( 30042101 )
2018
23
Hemorrhage of MRI and Immunohistochemical Panels Distinguish Secretory Carcinoma From Acinic Cell Carcinoma. ( 30186957 )
2018
24
Primary acinic cell carcinoma of the breast: A case report with a clinicopathological and immunohistochemical study of a rare breast cancer subtype. ( 30305896 )
2018
25
Acinic cell carcinoma of parotid gland with cavernous sinus metastasis: A case report. ( 30488869 )
2018
26
The HTN3-MSANTD3 Fusion Gene Defines a Subset of Acinic Cell Carcinoma of the Salivary Gland. ( 30520817 )
2018
27
Primary acinic cell carcinoma of the esophagus. ( 30552027 )
2018
28
Acinar Cell Carcinoma of Pancreas: a Case Report and Review of Literature. ( 28660524 )
2017
29
Bouveret syndrome and pancreatic acinar cell carcinoma. ( 28135730 )
2017
30
Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres. ( 29158927 )
2017
31
Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: A case report. ( 28588779 )
2017
32
Pancreatic acinar cell carcinoma with extensive tumor embolism at the trunk of portal vein and pancreatic intraductal infiltration. ( 28921102 )
2017
33
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors. ( 29259370 )
2017
34
A primary pure pancreatic-type acinar cell carcinoma of the stomach: a case report. ( 28103943 )
2017
35
Acinar Cell Carcinoma in the Background of Chronic Calcific Pancreatitis. ( 28952013 )
2017
36
Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement: Two case reports and literature review. ( 28930825 )
2017
37
Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma. ( 28671770 )
2017
38
Successful chemotherapy with modified FOLFIRINOX for pancreatic acinar cell carcinoma. ( 29052123 )
2017
39
Acinar Cell Carcinoma of the Pancreas: A Case Report. ( 28919629 )
2017
40
Case report: primary acinar cell carcinoma of the liver treated with multimodality therapy. ( 29184698 )
2017
41
Severe panniculitis and polyarthritis caused by acinar cell carcinoma arising from an ectopic pancreas. ( 29167188 )
2017
42
Primary pancreatic-type acinar cell carcinoma of the jejunum with tumor thrombus extending into the mesenteric venous system: a case report and literature review. ( 28662660 )
2017
43
Establishment and characterization of a new human acinar cell carcinoma cell line, Faraz-ICR, from pancreas. ( 28215484 )
2017
44
Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation. ( 28702373 )
2017
45
Minor Salivary Gland Acinic Cell Carcinoma With Orbital Extension. ( 26068556 )
2017
46
Prognostic Factors Associated With Decreased Survival in Patients With Acinic Cell Carcinoma of the Parotid Gland. ( 27474461 )
2017
47
Ultrastructural Characterization of Mammary Analogue Secretory Carcinoma of the Salivary Glands: A Distinct Entity from Acinic Cell Carcinoma? ( 28194567 )
2017
48
Primary acinic cell carcinoma of the lung with psammoma bodies: A case report and review of literature. ( 28214199 )
2017
49
Ultrasound features of acinic cell carcinoma of the tongue: a rare case report. ( 28396757 )
2017
50
Utility of Immunohistochemistry and ETV6 (12p13) Gene Rearrangement in Identifying Secretory Carcinoma of Salivary Gland among Previously Diagnosed Cases of Acinic Cell Carcinoma. ( 28484662 )
2017

Variations for Acinar Cell Carcinoma

Copy number variations for Acinar Cell Carcinoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107120 19 1205798 1228434 Amplification LKB1 Acinar cell carcinoma
2 118120 17 7571720 7590868 Mutation TP53 Acinar cell carcinoma

Expression for Acinar Cell Carcinoma

Search GEO for disease gene expression data for Acinar Cell Carcinoma.

Pathways for Acinar Cell Carcinoma

GO Terms for Acinar Cell Carcinoma

Cellular components related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex GO:0032991 9.02 BCL10 BRCA2 CTNNB1 REG1A TP53

Biological processes related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.62 CTNNB1 REG1A SMAD4 TP53
2 response to gamma radiation GO:0010332 9.48 BRCA2 TP53
3 cell aging GO:0007569 9.46 BRCA2 TP53
4 cell proliferation GO:0008283 9.46 BRCA2 CTNNB1 SMAD4 TP53
5 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.43 BRCA2 TP53
6 female gonad development GO:0008585 9.4 BRCA2 SMAD4
7 gastrulation with mouth forming second GO:0001702 9.37 CTNNB1 SMAD4
8 positive regulation of histone H3-K4 methylation GO:0051571 9.26 CTNNB1 SMAD4
9 positive regulation of transcription, DNA-templated GO:0045893 9.02 BCL10 BRCA2 CTNNB1 SMAD4 TP53
10 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 8.96 BRCA2 TP53

Molecular functions related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.63 BCL10 BRCA2 REG1A SERPINA1 SMAD4 TP53
2 protein C-terminus binding GO:0008022 9.54 BCL10 BRCA2 CTNNB1
3 protein phosphatase binding GO:0019903 9.43 CTNNB1 REG1A TP53
4 I-SMAD binding GO:0070411 9.32 CTNNB1 SMAD4
5 RNA polymerase II transcription factor binding GO:0001085 9.13 CTNNB1 SMAD4 TP53
6 protease binding GO:0002020 8.92 BCL10 BRCA2 SERPINA1 TP53

Sources for Acinar Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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