MCID: ACN001
MIFTS: 49

Acinar Cell Carcinoma

Categories: Rare diseases, Cancer diseases

Aliases & Classifications for Acinar Cell Carcinoma

MalaCards integrated aliases for Acinar Cell Carcinoma:

Name: Acinar Cell Carcinoma 12 15 73
Acinic Cell Carcinoma 12 53
Carcinoma, Acinar Cell 44
Carcinoma Acinar Cell 55
Acinic Cell Tumor 53
Acinar Cell Tumor 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3025
MeSH 44 D018267
NCIt 50 C3768
SNOMED-CT 68 45410002

Summaries for Acinar Cell Carcinoma

Disease Ontology : 12 A carcinoma that has material basis in abnormally proliferating cells, derives from spindle cells and/or derives from giant cells.

MalaCards based summary : Acinar Cell Carcinoma, also known as acinic cell carcinoma, is related to pancreatic acinar cell adenocarcinoma and cowden disease. An important gene associated with Acinar Cell Carcinoma is CHGA (Chromogranin A), and among its related pathways/superpathways are Pathways in cancer and Gastric cancer. The drugs Fluorouracil and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include pancreas, salivary gland and liver, and related phenotypes are Decreased viability in esophageal squamous lineage and Reduced mammosphere formation

Related Diseases for Acinar Cell Carcinoma

Diseases related to Acinar Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 pancreatic acinar cell adenocarcinoma 32.9 AFP BCL10 CHGA
2 cowden disease 30.5 BRCA2 CHGA SMAD4
3 pancreatoblastoma 30.2 AFP CHGA SERPINA1
4 adenoma 29.8 CTNNB1 SMAD4 TP53
5 adenocarcinoma 29.4 CTNNB1 NTRK3 SMAD4 TP53
6 pancreas adenocarcinoma 29.3 BRCA2 CTNNB1 SMAD4 TP53
7 acinar cell carcinoma of pancreas 12.5
8 uterine corpus serous adenocarcinoma 10.8 BRCA2 TP53
9 tetraploidy 10.8 BRCA2 TP53
10 cellular ependymoma 10.8 CHGA TP53
11 pancreatitis 10.8
12 olfactory groove meningioma 10.8 CHGA TP53
13 familial colorectal cancer type x 10.8 BRCA2 SMAD4
14 atypical follicular adenoma 10.8 CHGA TP53
15 synchronous bilateral breast carcinoma 10.8 BRCA2 TP53
16 fallopian tube adenocarcinoma 10.8 BRCA2 TP53
17 adult teratoma 10.7 AFP CHGA
18 anterior cranial fossa meningioma 10.7 CHGA TP53
19 mutyh-associated polyposis 10.7 SMAD4 TP53
20 sclerosing hepatic carcinoma 10.7 AFP CHGA
21 pulmonary blastoma 10.7 CHGA TP53
22 urethral benign neoplasm 10.7 CHGA SMAD4
23 vaginal benign neoplasm 10.6 CHGA KRT7
24 ovarian large-cell neuroendocrine carcinoma 10.6 CHGA KRT7
25 vaginal adenoma 10.6 CHGA KRT7
26 vaginal tubulovillous adenoma 10.6 CHGA KRT7
27 liver sarcoma 10.6 AFP CHGA
28 pleomorphic xanthoastrocytoma 10.6 CHGA TP53
29 gastric lymphoma 10.6 BCL10 TP53
30 small cell carcinoma of the bladder 10.6 CHGA KRT7
31 malignant spiradenoma 10.6 KRT7 TP53
32 colloid carcinoma of the pancreas 10.6 BRCA2 SMAD4
33 orofaciodigital syndrome viii 10.6 AFP BCL10
34 eccrine sweat gland neoplasm 10.6 KRT7 TP53
35 pancreatic serous cystadenoma 10.6 CHGA KRT7
36 scrotal carcinoma 10.6 AFP TP53
37 mature teratoma 10.6 AFP TP53
38 bladder carcinoma in situ 10.6 KRT7 TP53
39 esophagus adenocarcinoma 10.6 SMAD4 TP53
40 acinar cell cystadenocarcinoma 10.6 CHGA SERPINA1
41 papillary serous adenocarcinoma 10.6 KRT7 TP53
42 nasal cavity adenocarcinoma 10.6 KRT7 TP53
43 spiradenoma 10.5 KRT7 TP53
44 intrahepatic bile duct adenoma 10.5 AFP KRT7
45 ampulla of vater adenocarcinoma 10.5 BRCA2 KRT7
46 clear cell adenofibroma 10.5 BRCA2 KRT7
47 renal pelvis adenocarcinoma 10.5 AFP KRT7
48 ovarian germ cell cancer 10.5 AFP KRT7
49 pleomorphic carcinoma 10.5 KRT7 TP53
50 bile duct cystadenocarcinoma 10.5 AFP KRT7

Graphical network of the top 20 diseases related to Acinar Cell Carcinoma:



Diseases related to Acinar Cell Carcinoma

Symptoms & Phenotypes for Acinar Cell Carcinoma

GenomeRNAi Phenotypes related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.56 KRT7 SMAD4 TP53 AFP BCL10 BRCA2
2 Reduced mammosphere formation GR00396-S 9.1 ETV6 KRT7 REG1A SMAD4 AFP CHGA

MGI Mouse Phenotypes related to Acinar Cell Carcinoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.97 BRCA2 TP53 CHGA CTNNB1 ETV6 AFP
2 homeostasis/metabolism MP:0005376 9.91 SMAD4 BRCA2 TP53 CHGA CTNNB1 ETV6
3 embryo MP:0005380 9.85 BCL10 SMAD4 BRCA2 TP53 CTNNB1 ETV6
4 mortality/aging MP:0010768 9.81 SMAD4 BRCA2 TP53 CHGA CTNNB1 ETV6
5 neoplasm MP:0002006 9.43 BRCA2 TP53 CTNNB1 ETV6 AFP SMAD4
6 reproductive system MP:0005389 9.17 SMAD4 BRCA2 TP53 CHGA CTNNB1 AFP

Drugs & Therapeutics for Acinar Cell Carcinoma

Drugs for Acinar Cell Carcinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 113)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Fluorouracil Approved Phase 3,Phase 2,Phase 1,Not Applicable 51-21-8 3385
2
Gemcitabine Approved Phase 3,Phase 2,Phase 1,Not Applicable 95058-81-4 60750
3
Levoleucovorin Approved, Investigational Phase 3,Phase 2,Phase 1 68538-85-2
4
Pancrelipase Approved, Investigational Phase 3,Phase 2,Phase 1,Not Applicable 53608-75-6
5
Doxepin Approved, Investigational Phase 3 1668-19-5 667477 667468
6
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
7
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
8
Capecitabine Approved, Investigational Phase 3,Phase 2,Not Applicable 154361-50-9 60953
9
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3,Phase 2,Phase 1 59-30-3 6037
10
leucovorin Approved, Nutraceutical Phase 3,Phase 2,Phase 1,Not Applicable 58-05-9 143 6006
11 Pancreatic Polypeptide Investigational Phase 3 59763-91-6
12 Immunosuppressive Agents Phase 3,Phase 2,Phase 1,Not Applicable
13 Liver Extracts Phase 3,Phase 1,Not Applicable
14 Antidotes Phase 3,Phase 2,Phase 1
15 Anti-Infective Agents Phase 3,Phase 2,Phase 1,Not Applicable
16 Antimetabolites Phase 3,Phase 2,Phase 1,Not Applicable
17 Antimetabolites, Antineoplastic Phase 3,Phase 2,Phase 1,Not Applicable
18 Antiviral Agents Phase 3,Phase 2,Phase 1,Not Applicable
19 Calcium, Dietary Phase 3,Phase 2,Phase 1
20 Micronutrients Phase 3,Phase 2,Phase 1
21 pancreatin Phase 3,Phase 2,Phase 1,Not Applicable
22 Protective Agents Phase 3,Phase 2,Phase 1
23 Trace Elements Phase 3,Phase 2,Phase 1
24 Vitamin B Complex Phase 3,Phase 2,Phase 1
25 Vitamins Phase 3,Phase 2,Phase 1
26 Antidepressive Agents Phase 3
27 Antidepressive Agents, Tricyclic Phase 3
28 Histamine Antagonists Phase 3
29
Histamine Phosphate Phase 3 51-74-1 65513
30 Neurotransmitter Agents Phase 3
31 Psychotropic Drugs Phase 3
32 Adjuvants, Anesthesia Phase 3
33 Analgesics Phase 3
34 Analgesics, Opioid Phase 3
35 Anesthetics Phase 3
36 Anesthetics, General Phase 3
37 Anesthetics, Intravenous Phase 3
38 Central Nervous System Depressants Phase 3
39 Narcotics Phase 3
40 Peripheral Nervous System Agents Phase 3
41 Protein Kinase Inhibitors Phase 3,Phase 2,Phase 1
42
Erlotinib Hydrochloride Phase 3,Phase 1 183319-69-9 176871
43 Cola Nutraceutical Phase 3,Not Applicable
44 Folate Nutraceutical Phase 3,Phase 2,Phase 1
45 Vitamin B9 Nutraceutical Phase 3,Phase 2,Phase 1
46
Oxaliplatin Approved, Investigational Phase 2,Phase 1,Not Applicable 61825-94-3 5310940 9887054 43805 6857599
47
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
48
Paclitaxel Approved, Vet_approved Phase 2,Phase 1 33069-62-4 36314
49
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860
50
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102

Interventional clinical trials:

(show all 46)
# Name Status NCT ID Phase Drugs
1 Two Chemotherapy Regimens Compared With Observation in Treating Patients With Completely Resected Pancreatic Cancer Completed NCT00058201 Phase 3 fluorouracil;gemcitabine hydrochloride;leucovorin calcium
2 Doxepin Hydrochloride in Treating Oral Mucositis Pain in Patients With Head and Neck Cancer Undergoing Radiation Therapy With or Without Chemotherapy Completed NCT01156142 Phase 3 doxepin hydrochloride
3 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
4 Gemcitabine Hydrochloride With or Without Erlotinib Hydrochloride Followed by the Same Chemotherapy Regimen With or Without Radiation Therapy and Capecitabine or Fluorouracil in Treating Patients With Pancreatic Cancer That Has Been Removed by Surgery Active, not recruiting NCT01013649 Phase 3 Capecitabine;Chemotherapy;Erlotinib Hydrochloride;Fluorouracil;Gemcitabine Hydrochloride
5 Selumetinib and Akt Inhibitor MK2206 or mFOLFOX Therapy Comprising Oxaliplatin and Fluorouracil in Treating Patients With Metastatic Pancreatic Cancer Previously Treated With Chemotherapy Completed NCT01658943 Phase 2 Akt Inhibitor MK2206;Fluorouracil;Oxaliplatin;Selumetinib
6 Carboplatin and Paclitaxel With or Without Viral Therapy in Treating Patients With Recurrent or Metastatic Pancreatic Cancer Completed NCT01280058 Phase 2 Carboplatin;Paclitaxel
7 Bortezomib and Carboplatin in Treating Patients With Metastatic Pancreatic Cancer Completed NCT00416793 Phase 2 bortezomib;carboplatin
8 Gemcitabine in Treating Patients With Advanced Salivary Gland Cancer That Cannot Be Removed During Surgery Completed NCT00003744 Phase 2 gemcitabine
9 Sunitinib in Treating Patients With Metastatic Pancreatic Cancer That Progressed After First-Line Therapy With Gemcitabine Completed NCT00397787 Phase 2 sunitinib malate
10 Triapine as First-Line or Second-Line Therapy in Treating Patients With Locally Advanced or Metastatic Cancer of the Pancreas Completed NCT00085371 Phase 2 triapine
11 Paclitaxel and Bryostatin 1 in Treating Patients With Advanced Pancreatic Cancer Completed NCT00031694 Phase 2 paclitaxel;bryostatin 1
12 Dasatinib and Gemcitabine Hydrochloride or Gemcitabine Hydrochloride Alone in Treating Patients With Pancreatic Cancer Previously Treated With Surgery Completed NCT01234935 Phase 2 dasatinib;gemcitabine hydrochloride
13 Lapatinib in Treating Patients With Recurrent and/or Metastatic Adenoid Cystic Cancer or Other Salivary Gland Cancers Completed NCT00095563 Phase 2 lapatinib ditosylate
14 Trastuzumab in Treating Patients With Advanced Salivary Gland Cancer Completed NCT00004163 Phase 2 Trastuzumab
15 Cisplatin or Carboplatin Combined With Gemcitabine in Treating Patients With Locally Advanced, Recurrent, or Metastatic Malignant Salivary Gland Tumor Completed NCT00079079 Phase 2 carboplatin;cisplatin;gemcitabine hydrochloride
16 Nivolumab and Ipilimumab in Treating Patients With Rare Tumors Recruiting NCT02834013 Phase 2
17 Combination Chemotherapy Before and After Surgery in Treating Patients With Localized Pancreatic Cancer Recruiting NCT02047474 Phase 2 oxaliplatin;leucovorin calcium;irinotecan hydrochloride;fluorouracil
18 Selinexor, Gemcitabine Hydrochloride, and Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Metastatic Pancreatic Cancer Active, not recruiting NCT02178436 Phase 1, Phase 2 gemcitabine hydrochloride;paclitaxel albumin-stabilized nanoparticle formulation;selinexor
19 Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer Active, not recruiting NCT01666730 Phase 2 metformin hydrochloride;oxaliplatin;leucovorin calcium;fluorouracil
20 Mitomycin C and Ifosfamide in Treating Patients With Metastatic Pancreatic Cancer Terminated NCT00967291 Phase 2 ifosfamide;mitomycin C
21 Trastuzumab in Treating Patients With Metastatic or Recurrent Salivary Gland Cancer Terminated NCT00126607 Phase 2
22 Title XELOX FOR SALIVARY GLAND CANCERS Terminated NCT00101075 Phase 2 Capecitabine;Oxaliplatin
23 CPI-613 in Treating Patients With Locally Advanced or Metastatic Pancreatic Cancer Completed NCT01839981 Phase 1 6,8-bis(benzylthio)octanoic acid
24 Sorafenib Tosylate and Everolimus in Treating Patients With Advanced Solid Tumors and Metastatic Pancreatic Cancer That Does Not Respond to Gemcitabine Hydrochloride Completed NCT00981162 Phase 1 sorafenib tosylate;everolimus
25 Vaccine Therapy and Sargramostim in Treating Patients With Pancreas Cancer That Cannot Be Removed By Surgery Active, not recruiting NCT00669734 Phase 1
26 Ultrasound-Guided Photodynamic Therapy With Photofrin & Gemcitabine for Patients With Locally Advanced Pancreatic Cancer Active, not recruiting NCT01770132 Phase 1 porfimer sodium;gemcitabine hydrochloride
27 CPI-613 and Combination Chemotherapy in Treating Patients With Metastatic Pancreatic Cancer Active, not recruiting NCT01835041 Phase 1 6,8-bis(benzylthio)octanoic acid;oxaliplatin;leucovorin calcium;irinotecan hydrochloride;fluorouracil
28 GDC-0449 and Erlotinib Hydrochloride With or Without Gemcitabine Hydrochloride in Treating Patients With Metastatic Pancreatic Cancer or Solid Tumors That Cannot Be Removed by Surgery Active, not recruiting NCT00878163 Phase 1 Erlotinib Hydrochloride;Gemcitabine Hydrochloride;Vismodegib
29 Alisertib and Gemcitabine Hydrochloride in Treating Patients With Solid Tumors or Pancreatic Cancer Active, not recruiting NCT01924260 Phase 1 alisertib;gemcitabine
30 Genotype-guided Dosing of mFOLFIRINOX Chemotherapy in Patients With Previously Untreated Advanced Gastrointestinal Malignancies Active, not recruiting NCT01643499 Phase 1 oxaliplatin;irinotecan hydrochloride;leucovorin calcium;fluorouracil
31 Sirolimus and Vismodegib in Treating Patients With Solid Tumors or Pancreatic Cancer That is Metastatic or Cannot Be Removed By Surgery Suspended NCT01537107 Phase 1 vismodegib;sirolimus
32 Chemoradiation and Radiosurgery Boost in Treating Patients With Locally Advance Pancreatic Cancer That May or May Not be Removed by Surgery Terminated NCT01739439 Phase 1 gemcitabine hydrochloride
33 Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With Metastases to the Liver or Lung Withdrawn NCT01741597 Phase 1
34 MRI Mapping in Planning Radiation Therapy to the Base of Skull and Brain in Patients With Nonmetastatic Head and Neck Cancer Unknown status NCT00984074
35 Cyclophosphamide and Cryoablation in Treating Patients With Advanced or Metastatic Epithelial Cancer Unknown status NCT00499733 Not Applicable cyclophosphamide
36 Chemotherapy and Radiation Therapy Before Surgery Followed by Gemcitabine in Treating Patients With Pancreatic Cancer Completed NCT01821612 Not Applicable oxaliplatin;irinotecan;leucovorin;5-fluorouracil;capecitabine;gemcitabine
37 Growth Factor Levels in the Blood of Patients Undergoing Radiation Therapy for Epithelial Cancer Completed NCT00897793
38 Stereotactic Radiosurgery in Treating Patients With Locally Advanced or Recurrent Head and Neck Cancer Completed NCT00851253 Not Applicable
39 Using Traditional Acupuncture in the Management of Cancer Treatment Related Lymphoedema Completed NCT00828516 Not Applicable
40 PET Scans in Patients With Head And Neck Cancer Who Are Undergoing 3-Dimensional Conformal Radiation Therapy And Intensity-Modulated Radiation Therapy Completed NCT00809016 Not Applicable
41 Head & Neck Cancer Survivorship: Physical and Functional Status Completed NCT00751816 systemic chemotherapy
42 Family Quality of Life Among Families With a Member Who is a Cancer Patient Completed NCT00544336
43 Stereotactic Radiosurgery and Metformin in Patients With Borderline-Resectable or Locally-Advanced Pancreatic Cancer Recruiting NCT02153450 Early Phase 1 metformin hydrochloride
44 High Volume Washing of the Abdomen in Increasing Survival After Surgery in Patients With Pancreatic Cancer That Can Be Removed by Surgery Recruiting NCT02757859 Not Applicable
45 Incidence of POPF in the Resection of the Left Pancreas With RFAT Recruiting NCT03570502
46 Surgery for Pancreatic Tumors and Collection of Tumor Tissue for Study Terminated NCT00100321

Search NIH Clinical Center for Acinar Cell Carcinoma

Cochrane evidence based reviews: carcinoma, acinar cell

Genetic Tests for Acinar Cell Carcinoma

Anatomical Context for Acinar Cell Carcinoma

MalaCards organs/tissues related to Acinar Cell Carcinoma:

41
Pancreas, Salivary Gland, Liver, Brain, Lung, Breast, Skin

Publications for Acinar Cell Carcinoma

Articles related to Acinar Cell Carcinoma:

(show top 50) (show all 239)
# Title Authors Year
1
Curative distal pancreatectomy in patients with acinar cell carcinoma of pancreas diagnosed by endoscopic aspiration via esophago-jejunostomy: A successful case report. ( 29331883 )
2018
2
Hepatobiliary and Pancreatic: Primary acinar cell carcinoma of the liver showing good response to chemotherapy. ( 29659083 )
2018
3
BRAF gene rearrangements can be identified by FISH studies in pancreatic acinar cell carcinoma. ( 29506751 )
2018
4
Pancreatic panniculitis as a presentation symptom of acinar cell carcinoma. ( 29527901 )
2018
5
<i>EGFR</i> amplification induces sensitivity to anti<i>EGFR</i> therapy in pancreatic acinar cell carcinoma. ( 29666669 )
2018
6
Acinar Cell Carcinoma of Pancreas: a Case Report and Review of Literature. ( 28660524 )
2017
7
Bouveret syndrome and pancreatic acinar cell carcinoma. ( 28135730 )
2017
8
Liver Metastases in Pancreatic Acinar Cell Carcinoma Treated with Selective Internal Radiation Therapy with Y-90 Resin Microspheres. ( 29158927 )
2017
9
Pancreatic acinar cell carcinoma presenting with panniculitis, successfully treated with FOLFIRINOX: A case report. ( 28588779 )
2017
10
Pancreatic acinar cell carcinoma with extensive tumor embolism at the trunk of portal vein and pancreatic intraductal infiltration. ( 28921102 )
2017
11
Pancreatic acinar cell carcinoma: A review on molecular profiling of patient tumors. ( 29259370 )
2017
12
A primary pure pancreatic-type acinar cell carcinoma of the stomach: a case report. ( 28103943 )
2017
13
Acinar Cell Carcinoma in the Background of Chronic Calcific Pancreatitis. ( 28952013 )
2017
14
Acinar cell carcinoma of the pancreas presenting as diffuse pancreatic enlargement: Two case reports and literature review. ( 28930825 )
2017
15
Clinical outcomes of patients with resectable pancreatic acinar cell carcinoma. ( 28671770 )
2017
16
Successful chemotherapy with modified FOLFIRINOX for pancreatic acinar cell carcinoma. ( 29052123 )
2017
17
Acinar Cell Carcinoma of the Pancreas: A Case Report. ( 28919629 )
2017
18
Case report: primary acinar cell carcinoma of the liver treated with multimodality therapy. ( 29184698 )
2017
19
Severe panniculitis and polyarthritis caused by acinar cell carcinoma arising from an ectopic pancreas. ( 29167188 )
2017
20
Primary pancreatic-type acinar cell carcinoma of the jejunum with tumor thrombus extending into the mesenteric venous system: a case report and literature review. ( 28662660 )
2017
21
Establishment and characterization of a new human acinar cell carcinoma cell line, Faraz-ICR, from pancreas. ( 28215484 )
2017
22
Murine Pancreatic Acinar Cell Carcinoma Growth Kinetics Are Independent of Dietary Vitamin D Deficiency or Supplementation. ( 28702373 )
2017
23
Metastatic pancreatic acinar cell carcinoma in a younger male with marked AFP production: A potential pitfall on fine needle aspiration biopsy. ( 27634114 )
2016
24
Acinar cell carcinoma of the pancreas: a rare disease with different diagnostic and therapeutic implications than ductal adenocarcinoma. ( 27629876 )
2016
25
KRAS Mutations in Canine and Feline Pancreatic Acinar Cell Carcinoma. ( 27290644 )
2016
26
Efficacy of Chemotherapy in Patients with Unresectable or Metastatic Pancreatic Acinar Cell Carcinoma: Potentially Improved Efficacy with Oxaliplatin-containing Regimen. ( 27857025 )
2016
27
Pancreatic panniculitis in a patient with pancreatic-type acinar cell carcinoma of the liver - case report and review of literature. ( 26895632 )
2016
28
Pancreatic-type Acinar Cell Carcinoma of the Stomach Included in Multiple Primary Carcinomas. ( 27272797 )
2016
29
Acinar cell carcinoma: a report of 19 cases with a brief review of the literature. ( 27352960 )
2016
30
Endoscopic ultrasound in the diagnosis of acinar cell carcinoma of the pancreas: contrast-enhanced endoscopic ultrasound, endoscopic ultrasound elastography, and pathological correlation. ( 27853750 )
2016
31
Pancreatic panniculitis as a paraneoplastic phenomenon of a pancreatic acinar cell carcinoma. ( 27112929 )
2016
32
A comparison study of pancreatic acinar cell carcinoma with ductal adenocarcinoma using computed tomography in Chinese patients. ( 27660464 )
2016
33
TP53 alterations in pancreatic acinar cell carcinoma: new insights into the molecular pathology of this rare cancer. ( 26586531 )
2016
34
Omental acinar cell carcinoma of pancreatic origin in a child: a clinicopathological rarity. ( 26694824 )
2016
35
Cytological findings of an ectopic pancreas of the stomach obtained at endoscopic ultrasound-guided fine needle aspiration, differential diagnosis from acinar cell carcinoma: a case report. ( 26786071 )
2016
36
Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin. ( 27165126 )
2016
37
Cytological findings and BCL10 expression in pancreatic acinar cell carcinoma: A Case Report. ( 27860444 )
2016
38
Pancreatic Acinar Cell Carcinoma. ( 27403122 )
2016
39
Systematic Review and Case Series Report of Acinar Cell Carcinoma of the Pancreas. ( 27842335 )
2016
40
Expression of Albumin mRNA in Primary Hepatic Neoplasms and Acinar Cell Carcinoma. ( 26171921 )
2015
41
Pancreatic acinar cell carcinoma with bilateral ovarian metastases, panniculitis and polyarthritis treated with FOLFIRINOX chemotherapy regimen. A case report and review of the literature. ( 25959244 )
2015
42
ACINAR CELL CARCINOMA OF PANCREAS IN A CHILD: A RADIOLOGICAL PERSPECTIVE. ( 27004357 )
2015
43
Multimodal approach and long-term survival in a patient with recurrent metastatic acinar cell carcinoma of the pancreas: A case report. ( 26456669 )
2015
44
Pancreas-specific activation of mTOR and loss of p53 induce tumors reminiscent of acinar cell carcinoma. ( 26683340 )
2015
45
Acinar Cell Carcinoma of the Pancreas: Overview of Clinicopathologic Features and Insights into the Molecular Pathology. ( 26137463 )
2015
46
E-cadherin-negative acinar cell carcinoma of the pancreas: report of a case showing a solid pseudopapillary growth pattern. ( 25600280 )
2015
47
Prolonged Survival in a Patient with a Pancreatic Acinar Cell Carcinoma. ( 26600777 )
2015
48
Acinar Cell Carcinoma of the Pancreas: A Literature Review and Update. ( 26246707 )
2015
49
Clinical features and CT/MRI findings of pancreatic acinar cell carcinoma. ( 26628966 )
2015
50
Long-term survival following pancreatectomy and s-1 chemotherapy for pancreatic acinar cell carcinoma with peritoneal dissemination: a case report and literature review. ( 25569665 )
2015

Variations for Acinar Cell Carcinoma

Copy number variations for Acinar Cell Carcinoma from CNVD:

7
# CNVD ID Chromosom Start End Type Gene Symbol CNVD Disease
1 107120 19 1205798 1228434 Amplification LKB1 Acinar cell carcinoma
2 118120 17 7571720 7590868 Mutation TP53 Acinar cell carcinoma

Expression for Acinar Cell Carcinoma

Search GEO for disease gene expression data for Acinar Cell Carcinoma.

Pathways for Acinar Cell Carcinoma

GO Terms for Acinar Cell Carcinoma

Biological processes related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.56 BRCA2 CTNNB1 SMAD4 TP53
2 response to gamma radiation GO:0010332 9.51 BRCA2 TP53
3 cell aging GO:0007569 9.49 BRCA2 TP53
4 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:0042771 9.48 BRCA2 TP53
5 female gonad development GO:0008585 9.46 BRCA2 SMAD4
6 positive regulation of apoptotic process GO:0043065 9.46 BCL10 CTNNB1 NTRK3 TP53
7 response to X-ray GO:0010165 9.43 BRCA2 TP53
8 gastrulation with mouth forming second GO:0001702 9.4 CTNNB1 SMAD4
9 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 9.37 BRCA2 TP53
10 positive regulation of transcription, DNA-templated GO:0045893 9.35 BCL10 BRCA2 CTNNB1 SMAD4 TP53
11 positive regulation of histone H3-K4 methylation GO:0051571 9.32 CTNNB1 SMAD4
12 negative regulation of cell death GO:0060548 8.8 CTNNB1 NTRK3 SMAD4

Molecular functions related to Acinar Cell Carcinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.65 BCL10 BRCA2 SERPINA1 SMAD4 TP53
2 protein C-terminus binding GO:0008022 9.5 BCL10 BRCA2 CTNNB1
3 I-SMAD binding GO:0070411 9.16 CTNNB1 SMAD4
4 RNA polymerase II transcription factor binding GO:0001085 9.13 CTNNB1 SMAD4 TP53
5 protease binding GO:0002020 8.92 BCL10 BRCA2 SERPINA1 TP53

Sources for Acinar Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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