MCID: ACN003
MIFTS: 36

Acneiform Dermatitis

Categories: Skin diseases

Aliases & Classifications for Acneiform Dermatitis

MalaCards integrated aliases for Acneiform Dermatitis:

Name: Acneiform Dermatitis 12 15
Dermatitis Acneiform 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4399
NCIt 50 C35277
UMLS 73 C0234894

Summaries for Acneiform Dermatitis

MalaCards based summary : Acneiform Dermatitis, also known as dermatitis acneiform, is related to sigmoid neoplasm and periampullary adenoma. An important gene associated with Acneiform Dermatitis is UBR5 (Ubiquitin Protein Ligase E3 Component N-Recognin 5), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Docetaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and breast, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Acneiform Dermatitis

Diseases related to Acneiform Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 sigmoid neoplasm 10.2 HRAS KRAS
2 periampullary adenoma 10.2 HRAS KRAS
3 giant congenital nevus 10.2 HRAS NRAS
4 bile duct cysts 10.2 HRAS KRAS
5 appendix disease 10.2 HRAS KRAS
6 benign struma ovarii 10.2 HRAS NRAS
7 nasal cavity adenocarcinoma 10.2 HRAS KRAS
8 secondary hypertrophic osteoarthropathy 10.2 HRAS KRAS
9 melanomatosis 10.2 HRAS NRAS
10 anal canal adenocarcinoma 10.2 HRAS KRAS
11 marcus gunn phenomenon 10.2 HRAS NRAS
12 malignant struma ovarii 10.2 HRAS NRAS
13 nodular malignant melanoma 10.2 HRAS NRAS
14 prostate adenoid cystic carcinoma 10.1 HRAS PIK3CA
15 rare adenocarcinoma of the breast 10.1 KRAS PIK3CA
16 fetal adenoma 10.1 HRAS NRAS
17 ethmoid sinus cancer 10.1 HRAS PIK3CA
18 malignant conjunctival melanoma 10.1 HRAS MAP2K7 NRAS
19 ethmoid sinus adenocarcinoma 10.1 HRAS PIK3CA
20 schimmelpenning-feuerstein-mims syndrome 10.1 HRAS KRAS NRAS
21 myelodysplastic myeloproliferative cancer 10.1 HRAS NRAS
22 core binding factor acute myeloid leukemia 10.1 HRAS KRAS NRAS
23 liver angiosarcoma 10.1 HRAS KRAS NRAS
24 leukemia, chronic lymphocytic 2 10.1 HRAS KRAS NRAS
25 meningeal melanomatosis 10.1 HRAS NRAS
26 costello syndrome 10.1 HRAS KRAS MAP2K1
27 ovarian cystadenocarcinoma 10.1 HRAS KRAS
28 pulmonic stenosis 10.1 HRAS KRAS MAP2K1
29 melanocytic nevus syndrome, congenital 10.1 HRAS NRAS
30 autoimmune lymphoproliferative syndrome 10.1 HRAS KRAS NRAS
31 ovarian melanoma 10.1 HRAS MAP2K1 NRAS
32 lung benign neoplasm 10.1 EGFR HRAS KRAS
33 colonic disease 10.1 EGFR HRAS KRAS
34 apocrine adenoma 10.1 HRAS KRAS PIK3CA
35 colorectal adenocarcinoma 10.1 EGFR HRAS KRAS
36 aggressive digital papillary adenocarcinoma 10.1 HRAS KRAS PIK3CA
37 respiratory system disease 10.1 EGFR HRAS KRAS
38 breast intraductal proliferative lesion 10.1 EGFR ERBB2
39 lung adenoid cystic carcinoma 10.1 HRAS KRAS PIK3CA
40 erdheim-chester disease 10.1 NRAS PIK3CA
41 progesterone-receptor negative breast cancer 10.0 EGFR ERBB2
42 breast scirrhous carcinoma 10.0 EGFR ERBB2
43 biliary papillomatosis 10.0 HRAS KRAS
44 papillary hidradenoma 10.0 ERBB4 PIK3CA
45 vulvar melanoma 10.0 EIF2AK3 HRAS NRAS
46 cardiofaciocutaneous syndrome 1 10.0 HRAS KRAS MAP2K1 MAP2K7
47 paget disease, extramammary 10.0 ERBB2 ERBB4
48 pulmonary blastoma 10.0 EGFR KRAS
49 uterine corpus serous adenocarcinoma 10.0 ERBB2 PIK3CA
50 paronychia 10.0 EGFR HRAS KRAS MAP2K7

Graphical network of the top 20 diseases related to Acneiform Dermatitis:



Diseases related to Acneiform Dermatitis

Symptoms & Phenotypes for Acneiform Dermatitis

GenomeRNAi Phenotypes related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

26 (show all 24)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 11.03 HRAS KRAS PIK3CA EGFR
2 Decreased viability GR00106-A-0 11.03 KRAS
3 Decreased viability GR00107-A-1 11.03 MAP2K1
4 Decreased viability GR00221-A-1 11.03 EIF2AK3 HRAS KRAS PIK3CA EGFR MAP2K7
5 Decreased viability GR00221-A-2 11.03 EIF2AK3 HRAS KRAS PIK3CA
6 Decreased viability GR00221-A-3 11.03 HRAS ERBB2 MAP2K1 NRAS
7 Decreased viability GR00221-A-4 11.03 EIF2AK3 PIK3CA EGFR ERBB2
8 Decreased viability GR00301-A 11.03 KRAS ERBB4
9 Decreased viability GR00342-S-1 11.03 ERBB4 MAP2K1 MAP2K7
10 Decreased viability GR00342-S-2 11.03 MAP2K1
11 Decreased viability GR00342-S-3 11.03 MAP2K1
12 Decreased viability GR00381-A-1 11.03 KRAS
13 Decreased viability GR00402-S-2 11.03 EIF2AK3 HRAS KRAS PIK3CA EGFR ERBB2
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.92 UBR5
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.92 EIF2AK3
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.92 UBR5
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.92 EGFR EIF2AK3 UBR5
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.92 EIF2AK3
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.92 EGFR
20 Decreased cell migration GR00055-A-1 9.8 EGFR ERBB4 HRAS KRAS PIK3CA
21 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.77 EGFR ERBB2 ERBB4 HRAS NRAS
22 Increased cell migration GR00055-A-3 9.35 EGFR ERBB4 HRAS KRAS PIK3CA
23 Increased transferrin (TF) endocytosis GR00363-A 9.28 CYP1A1 EGFR EIF2AK3 ERBB2 ERBB4 HRAS
24 Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line GR00121-A 9.16 ERBB4 MAP2K1

MGI Mouse Phenotypes related to Acneiform Dermatitis:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.32 CYP1A1 EGFR ERBB2 ERBB4 HRAS KRAS
2 endocrine/exocrine gland MP:0005379 10.3 CYP1A1 EGFR EIF2AK3 ERBB2 ERBB4 HRAS
3 cellular MP:0005384 10.27 EGFR EIF2AK3 ERBB2 ERBB4 KRAS MAP2K1
4 growth/size/body region MP:0005378 10.25 CYP1A1 EGFR EIF2AK3 ERBB2 HRAS KRAS
5 behavior/neurological MP:0005386 10.24 EIF2AK3 ERBB2 ERBB4 HRAS KRAS MAP2K7
6 homeostasis/metabolism MP:0005376 10.24 CYP1A1 EGFR EIF2AK3 ERBB2 HRAS KRAS
7 mortality/aging MP:0010768 10.22 CYP1A1 EGFR EIF2AK3 ERBB2 ERBB4 HRAS
8 craniofacial MP:0005382 10.16 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
9 integument MP:0010771 10.16 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
10 embryo MP:0005380 10.14 EGFR ERBB2 ERBB4 KRAS MAP2K1 NRAS
11 digestive/alimentary MP:0005381 10.09 EGFR EIF2AK3 ERBB2 HRAS KRAS MAP2K1
12 immune system MP:0005387 10.08 CYP1A1 EGFR EIF2AK3 ERBB4 KRAS NRAS
13 nervous system MP:0003631 10.06 EGFR EIF2AK3 ERBB2 ERBB4 HRAS KRAS
14 neoplasm MP:0002006 10.02 EGFR EIF2AK3 ERBB2 HRAS KRAS MAP2K1
15 liver/biliary system MP:0005370 9.91 CYP1A1 EGFR EIF2AK3 KRAS NRAS SPEN
16 normal MP:0002873 9.81 CYP1A1 EGFR ERBB2 ERBB4 HRAS KRAS
17 no phenotypic analysis MP:0003012 9.8 CYP1A1 EGFR EIF2AK3 HRAS KRAS NRAS
18 reproductive system MP:0005389 9.5 EGFR ERBB2 ERBB4 KRAS MAP2K1 MAP2K7
19 skeleton MP:0005390 9.23 EGFR EIF2AK3 ERBB2 HRAS KRAS MAP2K1

Drugs & Therapeutics for Acneiform Dermatitis

Drugs for Acneiform Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 67)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
2
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
3
Cetuximab Approved Phase 3 205923-56-4 56842117 2333
4
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
5 Albumin-Bound Paclitaxel Phase 3
6 Antineoplastic Agents, Phytogenic Phase 3,Phase 2
7 Antimitotic Agents Phase 3
8 taxane Phase 3
9
Petrolatum Approved, Investigational Phase 2 8009-03-8
10
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
11
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
12
Hydroxyzine Approved Phase 2 68-88-2 3658
13
Clindamycin Approved, Vet_approved Phase 2 18323-44-9 29029
14
leucovorin Approved Phase 2 58-05-9 6006 143
15
Silver sulfadiazine Approved, Vet_approved Phase 2 22199-08-2 441244
16
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
17
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
18
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
19
Sulfadiazine Approved, Investigational, Vet_approved Phase 2 68-35-9 5215
20
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
21
Fluorouracil Approved Phase 2 51-21-8 3385
22
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
23
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
24
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
25
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
26
Camptothecin Experimental Phase 2 7689-03-4
27
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
28 Cortisol succinate Phase 2
29 Anti-Bacterial Agents Phase 2
30 Cola Phase 2
31 Anti-Infective Agents Phase 2
32 Antibiotics, Antitubercular Phase 2
33 Emollients Phase 2
34 Immunologic Factors Phase 2
35 Hydrocortisone-17-butyrate Phase 2
36 Antibodies, Monoclonal Phase 2
37 topoisomerase I inhibitors Phase 2
38 Sunscreening Agents Phase 2
39 Topoisomerase Inhibitors Phase 2
40 Radiation-Protective Agents Phase 2
41 Anti-Inflammatory Agents Phase 2
42 Histamine Antagonists Phase 2
43 Hydrocortisone 17-butyrate 21-propionate Phase 2
44 Clindamycin palmitate Phase 2
45 Clindamycin phosphate Phase 2
46 Histamine H1 Antagonists Phase 2
47 Clavulanic Acids Phase 2
48 Antibodies Phase 2
49 Dermatologic Agents Phase 2
50 Protective Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Taxane/Carboplatin +/- Cetuximab as First-Line Treatment for Patients With Advanced/Metastatic Non-Small Cell Lung Cancer Completed NCT00112294 Phase 3 Paclitaxel (Taxane);Docetaxel (Taxane);Carboplatin;Cetuximab
2 Skin Toxicity Treatment in Metastatic Colorectal Cancer (mCRC) Patients Receiving Panitumumab + Irinotecan-based Therapy Completed NCT00332163 Phase 2 Irinotecan;FOLFIRI;Pre-emptive Skin Treatment;Reactive Skin Treatment
3 Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO Completed NCT01465802 Phase 2 Dacomitinib;Dacomitinib;Doxycycline;Probiotic;Alclometasone cream

Search NIH Clinical Center for Acneiform Dermatitis

Genetic Tests for Acneiform Dermatitis

Anatomical Context for Acneiform Dermatitis

MalaCards organs/tissues related to Acneiform Dermatitis:

41
Skin, Lung, Breast, Ovary, Pancreas, Thyroid, Myeloid

Publications for Acneiform Dermatitis

Variations for Acneiform Dermatitis

Expression for Acneiform Dermatitis

Search GEO for disease gene expression data for Acneiform Dermatitis.

Pathways for Acneiform Dermatitis

Pathways related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 179)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
2
Show member pathways
13.93 EGFR EIF2AK3 ERBB2 ERBB4 HRAS KRAS
3
Show member pathways
13.89 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
4
Show member pathways
13.8 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
5
Show member pathways
13.78 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
6
Show member pathways
13.75 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
7
Show member pathways
13.64 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
8
Show member pathways
13.61 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
9
Show member pathways
13.6 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
10
Show member pathways
13.53 EGFR ERBB2 ERBB4 HRAS KRAS NRAS
11
Show member pathways
13.48 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
12
Show member pathways
13.48 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
13
Show member pathways
13.45 EGFR ERBB2 ERBB4 HRAS KRAS NRAS
14
Show member pathways
13.42 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
15
Show member pathways
13.4 EGFR EIF2AK3 ERBB2 ERBB4 HRAS KRAS
16
Show member pathways
13.36 EGFR ERBB2 HRAS KRAS MAP2K7 NRAS
17
Show member pathways
13.33 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
18
Show member pathways
13.19 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
19
Show member pathways
13.17 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
20
Show member pathways
13.11 EGFR HRAS KRAS MAP2K1 NRAS
21
Show member pathways
13.11 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
22
Show member pathways
13.1 EGFR HRAS KRAS MAP2K1 NRAS
23
Show member pathways
13.09 EGFR HRAS KRAS MAP2K1 NRAS
24
Show member pathways
13.09 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
25
Show member pathways
13.07 HRAS KRAS MAP2K1 MAP2K7 NRAS
26
Show member pathways
13.03 EGFR HRAS KRAS MAP2K1 NRAS PIK3CA
27
Show member pathways
13.03 EGFR EIF2AK3 ERBB2 HRAS KRAS MAP2K1
28
Show member pathways
13.02 EGFR ERBB2 HRAS KRAS MAP2K1 NRAS
29
Show member pathways
13.02 EGFR ERBB2 HRAS KRAS MAP2K1 MAP2K7
30
Show member pathways
13 HRAS KRAS MAP2K1 MAP2K7 NRAS
31
Show member pathways
12.99 HRAS KRAS MAP2K1 MAP2K7 NRAS
32 12.98 EGFR ERBB2 HRAS KRAS MAP2K1 NRAS
33
Show member pathways
12.97 HRAS KRAS MAP2K1 NRAS PIK3CA
34
Show member pathways
12.95 EIF2AK3 HRAS KRAS MAP2K1 NRAS PIK3CA
35
Show member pathways
12.93 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
36
Show member pathways
12.92 HRAS KRAS MAP2K1 NRAS PIK3CA
37
Show member pathways
12.9 HRAS KRAS MAP2K1 MAP2K7 NRAS
38
Show member pathways
12.9 EGFR ERBB2 HRAS KRAS MAP2K1 NRAS
39
Show member pathways
12.88 EGFR HRAS KRAS MAP2K1 NRAS PIK3CA
40
Show member pathways
12.87 EGFR ERBB2 ERBB4 HRAS KRAS NRAS
41
Show member pathways
12.86 EGFR ERBB2 HRAS KRAS MAP2K1 MAP2K7
42
Show member pathways
12.85 ERBB2 HRAS KRAS MAP2K1 MAP2K7 NRAS
43 12.85 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
44
Show member pathways
12.84 EGFR HRAS KRAS MAP2K1 NRAS
45
Show member pathways
12.83 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
46
Show member pathways
12.81 HRAS KRAS MAP2K1 PIK3CA
47
Show member pathways
12.81 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
48
Show member pathways
12.78 EGFR HRAS KRAS MAP2K1 NRAS
49 12.78 EGFR HRAS KRAS MAP2K1 NRAS PIK3CA
50
Show member pathways
12.75 EGFR ERBB2 HRAS KRAS NRAS PIK3CA

GO Terms for Acneiform Dermatitis

Cellular components related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perinuclear region of cytoplasm GO:0048471 9.35 EGFR EIF2AK3 ERBB2 HRAS UBR5
2 basal plasma membrane GO:0009925 8.8 EGFR ERBB2 ERBB4

Biological processes related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.93 EIF2AK3 ERBB2 HRAS KRAS MAP2K1 UBR5
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.89 EGFR ERBB2 ERBB4 HRAS MAP2K1
3 protein autophosphorylation GO:0046777 9.87 EGFR EIF2AK3 ERBB2 ERBB4
4 positive regulation of protein kinase B signaling GO:0051897 9.86 EGFR ERBB2 ERBB4 PIK3CA
5 positive regulation of MAPK cascade GO:0043410 9.84 EGFR ERBB2 ERBB4 HRAS
6 negative regulation of neuron apoptotic process GO:0043524 9.82 HRAS KRAS PIK3CA
7 negative regulation of signal transduction GO:0009968 9.81 EGFR ERBB2 ERBB4
8 phosphatidylinositol phosphorylation GO:0046854 9.81 EGFR ERBB2 ERBB4 PIK3CA
9 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.8 EGFR ERBB2 ERBB4
10 activation of protein kinase activity GO:0032147 9.8 MAP2K1 MAP2K7 PIK3CA
11 positive regulation of protein phosphorylation GO:0001934 9.8 EGFR ERBB2 ERBB4 HRAS KRAS
12 cell proliferation GO:0008283 9.8 CYP1A1 EGFR ERBB2 ERBB4 HRAS UBR5
13 phosphorylation GO:0016310 9.8 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
14 Ras protein signal transduction GO:0007265 9.78 HRAS KRAS NRAS
15 liver development GO:0001889 9.78 CYP1A1 EGFR KRAS PIK3CA
16 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.77 HRAS KRAS NRAS
17 peptidyl-tyrosine phosphorylation GO:0018108 9.77 EGFR ERBB2 ERBB4 MAP2K1 MAP2K7
18 positive regulation of epithelial cell proliferation GO:0050679 9.76 EGFR ERBB2 HRAS
19 cellular response to epidermal growth factor stimulus GO:0071364 9.75 EGFR ERBB2 ERBB4
20 positive regulation of MAP kinase activity GO:0043406 9.73 EGFR ERBB2 HRAS KRAS
21 regulation of cell motility GO:2000145 9.7 EGFR ERBB2 ERBB4
22 protein phosphorylation GO:0006468 9.7 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
23 cellular senescence GO:0090398 9.65 HRAS MAP2K1
24 regulation of long-term neuronal synaptic plasticity GO:0048169 9.65 HRAS KRAS
25 response to osmotic stress GO:0006970 9.65 EGFR MAP2K7
26 positive regulation of transcription by RNA polymerase I GO:0045943 9.63 EIF2AK3 ERBB2
27 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.62 EGFR MAP2K1
28 response to isolation stress GO:0035900 9.61 HRAS KRAS
29 negative regulation of ERBB signaling pathway GO:1901185 9.59 EGFR ERBB2
30 ERBB2 signaling pathway GO:0038128 9.26 EGFR ERBB2 ERBB4 PIK3CA
31 MAPK cascade GO:0000165 9.17 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
32 signal transduction GO:0007165 10.15 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1

Molecular functions related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.85 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
2 protein serine/threonine kinase activity GO:0004674 9.84 EIF2AK3 MAP2K1 MAP2K7 PIK3CA
3 enzyme binding GO:0019899 9.81 CYP1A1 EGFR EIF2AK3 MAP2K7
4 kinase activity GO:0016301 9.7 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.67 EGFR ERBB2 ERBB4
6 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.63 EGFR ERBB2 ERBB4
7 protein phosphatase binding GO:0019903 9.62 EGFR EIF2AK3 ERBB2 MAP2K7
8 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.56 EGFR ERBB2 ERBB4 PIK3CA
9 MAP kinase kinase activity GO:0004708 9.52 MAP2K1 MAP2K7
10 protein tyrosine kinase activity GO:0004713 9.35 EGFR ERBB2 ERBB4 MAP2K1 MAP2K7
11 nucleotide binding GO:0000166 9.17 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
12 protein binding GO:0005515 10.25 CYP1A1 EGFR EIF2AK3 ERBB2 ERBB4 HRAS
13 ATP binding GO:0005524 10.02 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
14 transferase activity GO:0016740 10.01 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7

Sources for Acneiform Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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