MCID: ACN003
MIFTS: 41

Acneiform Dermatitis

Categories: Skin diseases

Aliases & Classifications for Acneiform Dermatitis

MalaCards integrated aliases for Acneiform Dermatitis:

Name: Acneiform Dermatitis 12 15 17
Dermatitis Acneiform 74

Classifications:



External Ids:

Disease Ontology 12 DOID:4399
NCIt 51 C35277
UMLS 74 C0234894

Summaries for Acneiform Dermatitis

MalaCards based summary : Acneiform Dermatitis, also known as dermatitis acneiform, is related to sigmoid neoplasm and periampullary adenoma. An important gene associated with Acneiform Dermatitis is MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7), and among its related pathways/superpathways are Innate Immune System and Apoptotic Pathways in Synovial Fibroblasts. The drugs Paclitaxel and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include skin and lung, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Acneiform Dermatitis

Diseases related to Acneiform Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 118)
# Related Disease Score Top Affiliating Genes
1 sigmoid neoplasm 10.4 HRAS KRAS
2 periampullary adenoma 10.3 HRAS KRAS
3 bile duct cysts 10.3 HRAS KRAS
4 appendix disease 10.3 HRAS KRAS
5 nasal cavity adenocarcinoma 10.3 HRAS KRAS
6 secondary hypertrophic osteoarthropathy 10.3 HRAS KRAS
7 anal canal adenocarcinoma 10.3 HRAS KRAS
8 giant congenital nevus 10.2 HRAS NRAS
9 prostate adenoid cystic carcinoma 10.2 HRAS PIK3CA
10 benign struma ovarii 10.2 HRAS NRAS
11 ovarian cystadenocarcinoma 10.2 HRAS KRAS
12 rare adenocarcinoma of the breast 10.2 KRAS PIK3CA
13 ethmoid sinus cancer 10.2 HRAS PIK3CA
14 ethmoid sinus adenocarcinoma 10.2 HRAS PIK3CA
15 melanomatosis 10.2 HRAS NRAS
16 marcus gunn phenomenon 10.2 HRAS NRAS
17 biliary papillomatosis 10.2 HRAS KRAS
18 malignant struma ovarii 10.2 HRAS NRAS
19 nodular malignant melanoma 10.2 HRAS NRAS
20 pulmonary blastoma 10.2 EGFR KRAS
21 fetal adenoma 10.2 HRAS NRAS
22 lung benign neoplasm 10.1 EGFR HRAS KRAS
23 breast intraductal proliferative lesion 10.1 EGFR ERBB2
24 colonic disease 10.1 EGFR HRAS KRAS
25 myelodysplastic myeloproliferative cancer 10.1 HRAS NRAS
26 colorectal adenocarcinoma 10.1 EGFR HRAS KRAS
27 respiratory system disease 10.1 EGFR HRAS KRAS
28 meningeal melanomatosis 10.1 HRAS NRAS
29 progesterone-receptor negative breast cancer 10.1 EGFR ERBB2
30 breast scirrhous carcinoma 10.1 EGFR ERBB2
31 melanocytic nevus syndrome, congenital 10.1 HRAS NRAS
32 malignant conjunctival melanoma 10.1 HRAS MAP2K7 NRAS
33 costello syndrome 10.1 HRAS KRAS MAP2K1
34 pulmonic stenosis 10.1 HRAS KRAS MAP2K1
35 papillary hidradenoma 10.1 ERBB4 PIK3CA
36 colloid carcinoma of the pancreas 10.1 HRAS KRAS
37 apocrine adenoma 10.1 HRAS KRAS PIK3CA
38 rosai-dorfman disease 10.1 KRAS MAP2K1
39 schimmelpenning-feuerstein-mims syndrome 10.1 HRAS KRAS NRAS
40 aggressive digital papillary adenocarcinoma 10.1 HRAS KRAS PIK3CA
41 lung adenoid cystic carcinoma 10.1 HRAS KRAS PIK3CA
42 core binding factor acute myeloid leukemia 10.1 HRAS KRAS NRAS
43 liver angiosarcoma 10.1 HRAS KRAS NRAS
44 paget disease, extramammary 10.1 ERBB2 ERBB4
45 microglandular adenosis 10.1 EGFR ERBB2
46 leukemia, chronic lymphocytic 2 10.1 HRAS KRAS NRAS
47 inflammatory breast carcinoma 10.0 EGFR ERBB2
48 erdheim-chester disease 10.0 NRAS PIK3CA
49 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 10.0 KRAS PIK3CA
50 paronychia 10.0 EGFR HRAS KRAS MAP2K7

Graphical network of the top 20 diseases related to Acneiform Dermatitis:



Diseases related to Acneiform Dermatitis

Symptoms & Phenotypes for Acneiform Dermatitis

GenomeRNAi Phenotypes related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

27 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 11.03 HRAS KRAS PIK3CA EGFR
2 Decreased viability GR00106-A-0 11.03 KRAS
3 Decreased viability GR00107-A-1 11.03 MAP2K1
4 Decreased viability GR00221-A-1 11.03 EIF2AK3 HRAS KRAS PIK3CA MAP2K7 EGFR
5 Decreased viability GR00221-A-2 11.03 EIF2AK3 HRAS KRAS PIK3CA
6 Decreased viability GR00221-A-3 11.03 HRAS MAP2K1 ERBB2 NRAS
7 Decreased viability GR00221-A-4 11.03 EIF2AK3 PIK3CA EGFR ERBB2
8 Decreased viability GR00301-A 11.03 KRAS ERBB4
9 Decreased viability GR00342-S-1 11.03 ERBB4 MAP2K1 MAP2K7
10 Decreased viability GR00342-S-2 11.03 MAP2K1
11 Decreased viability GR00342-S-3 11.03 MAP2K1
12 Decreased viability GR00381-A-1 11.03 KRAS
13 Decreased viability GR00402-S-2 11.03 EIF2AK3 HRAS KRAS PIK3CA ERBB4 MAP2K1
14 Decreased cell migration GR00055-A-1 9.77 EGFR ERBB4 HRAS KRAS PIK3CA
15 Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance GR00210-A 9.72 EGFR ERBB2 ERBB4 HRAS NRAS
16 Increased cell migration GR00055-A-3 9.35 EGFR ERBB4 HRAS KRAS PIK3CA
17 Increased transferrin (TF) endocytosis GR00363-A 9.28 CYP1A1 EGFR EIF2AK3 ERBB2 ERBB4 HRAS
18 Decreased viability in Von Hippel-Lindau (VHL) (-/-) cell line GR00121-A 9.16 ERBB4 MAP2K1

MGI Mouse Phenotypes related to Acneiform Dermatitis:

47 (show all 21)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.33 CYP1A1 EGFR EIF2AK3 ERBB2 ERBB4 HRAS
2 cardiovascular system MP:0005385 10.29 CYP1A1 EGFR ERBB2 ERBB4 HRAS KRAS
3 behavior/neurological MP:0005386 10.25 EIF2AK3 ERBB2 ERBB4 HRAS KRAS MAP2K7
4 cellular MP:0005384 10.24 EGFR EIF2AK3 ERBB2 ERBB4 KRAS MAP2K1
5 growth/size/body region MP:0005378 10.24 CYP1A1 EGFR EIF2AK3 ERBB2 HRAS KRAS
6 homeostasis/metabolism MP:0005376 10.22 CYP1A1 EGFR EIF2AK3 ERBB2 HRAS KRAS
7 mortality/aging MP:0010768 10.21 CYP1A1 EGFR EIF2AK3 ERBB2 ERBB4 HRAS
8 integument MP:0010771 10.19 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
9 craniofacial MP:0005382 10.12 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
10 digestive/alimentary MP:0005381 10.11 EGFR EIF2AK3 ERBB2 HRAS KRAS MAP2K1
11 immune system MP:0005387 10.11 CYP1A1 EGFR EIF2AK3 ERBB4 KRAS NRAS
12 embryo MP:0005380 10.1 EGFR ERBB2 ERBB4 KRAS MAP2K1 NRAS
13 nervous system MP:0003631 10.07 EGFR EIF2AK3 ERBB2 ERBB4 HRAS KRAS
14 neoplasm MP:0002006 10.06 EGFR EIF2AK3 ERBB2 HRAS KRAS MAP2K1
15 liver/biliary system MP:0005370 9.93 CYP1A1 EGFR EIF2AK3 KRAS NRAS SPEN
16 normal MP:0002873 9.91 CYP1A1 EGFR ERBB2 ERBB4 HRAS KRAS
17 limbs/digits/tail MP:0005371 9.88 EGFR EIF2AK3 ERBB2 KRAS NRAS
18 no phenotypic analysis MP:0003012 9.87 CYP1A1 EGFR EIF2AK3 HRAS KRAS NRAS
19 reproductive system MP:0005389 9.7 EGFR ERBB2 ERBB4 KRAS MAP2K1 MAP2K7
20 skeleton MP:0005390 9.56 EGFR EIF2AK3 ERBB2 HRAS KRAS MAP2K1
21 vision/eye MP:0005391 9.1 EGFR KRAS MAP2K1 MAP2K7 NRAS PIK3CA

Drugs & Therapeutics for Acneiform Dermatitis

Drugs for Acneiform Dermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Paclitaxel Approved, Vet_approved Phase 3 33069-62-4 36314
2
Carboplatin Approved Phase 3 41575-94-4 38904 10339178 498142
3
Cetuximab Approved Phase 3 205923-56-4 56842117 2333
4
Docetaxel Approved, Investigational Phase 3 114977-28-5 148124
5 Antineoplastic Agents, Immunological Phase 3,Phase 2
6 Albumin-Bound Paclitaxel Phase 3
7 Antimitotic Agents Phase 3
8 Antineoplastic Agents, Phytogenic Phase 3
9 taxane Phase 3
10
Panitumumab Approved, Investigational Phase 2 339177-26-3 50070211
11
leucovorin Approved Phase 2 58-05-9 6006 143
12
Irinotecan Approved, Investigational Phase 2 100286-90-6, 97682-44-5 60838
13
Hydrocortisone Approved, Vet_approved Phase 2 50-23-7 5754
14
Ciprofloxacin Approved, Investigational Phase 2 85721-33-1 2764
15
Hydroxyzine Approved Phase 2 68-88-2 3658
16
Amoxicillin Approved, Vet_approved Phase 2 26787-78-0 33613
17
Doxycycline Approved, Investigational, Vet_approved Phase 2 564-25-0 54671203
18
Sulfadiazine Approved, Investigational, Vet_approved Phase 2 68-35-9 5215
19
Fluorouracil Approved Phase 2 51-21-8 3385
20
Hydrocortisone acetate Approved, Vet_approved Phase 2 50-03-3
21
Petrolatum Approved, Investigational Phase 2 8009-03-8
22
Silver sulfadiazine Approved, Vet_approved Phase 2 22199-08-2 441244
23
Clindamycin Approved, Vet_approved Phase 2 18323-44-9 29029
24
Clavulanate Approved, Vet_approved Phase 2 58001-44-8 5280980
25
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
26
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
27
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
28
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
29
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
30 Clindamycin phosphate Phase 2
31 Dermatologic Agents Phase 2
32 Radiation-Protective Agents Phase 2
33 Clindamycin palmitate Phase 2
34 Hydrocortisone hemisuccinate Phase 2
35 Histamine Antagonists Phase 2
36 Protective Agents Phase 2
37 Emollients Phase 2
38 Antitubercular Agents Phase 2
39 topoisomerase I inhibitors Phase 2
40 Antibiotics, Antitubercular Phase 2
41 Topoisomerase Inhibitors Phase 2
42 Anti-Infective Agents Phase 2
43 Histamine H1 Antagonists Phase 2
44 Hydrocortisone-17-butyrate Phase 2
45 Anti-Bacterial Agents Phase 2
46 Anti-Inflammatory Agents Phase 2
47 Hydrocortisone 17-butyrate 21-propionate Phase 2
48 Cola Phase 2
49 Sunscreening Agents Phase 2
50 Prednisolone acetate Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Taxane/Carboplatin +/- Cetuximab as First-Line Treatment for Patients With Advanced/Metastatic Non-Small Cell Lung Cancer Completed NCT00112294 Phase 3 Paclitaxel (Taxane);Docetaxel (Taxane);Carboplatin;Cetuximab
2 Skin Toxicity Treatment in Metastatic Colorectal Cancer (mCRC) Patients Receiving Panitumumab + Irinotecan-based Therapy Completed NCT00332163 Phase 2 Irinotecan;FOLFIRI;Pre-emptive Skin Treatment;Reactive Skin Treatment
3 Study Of Dacomitinib (PF-00299804) In Advanced NSCLC Patients (Post Chemo Or Select First Line) To Evaluate Prophylactic Intervention On Derm And GI AEs And PRO Completed NCT01465802 Phase 2 Dacomitinib;Dacomitinib;Doxycycline;Probiotic;Alclometasone cream

Search NIH Clinical Center for Acneiform Dermatitis

Genetic Tests for Acneiform Dermatitis

Anatomical Context for Acneiform Dermatitis

MalaCards organs/tissues related to Acneiform Dermatitis:

42
Skin, Lung

Publications for Acneiform Dermatitis

Variations for Acneiform Dermatitis

Expression for Acneiform Dermatitis

Search GEO for disease gene expression data for Acneiform Dermatitis.

Pathways for Acneiform Dermatitis

Pathways related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.06 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
2
Show member pathways
13.92 EGFR EIF2AK3 ERBB2 ERBB4 HRAS KRAS
3
Show member pathways
13.88 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
4
Show member pathways
13.79 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
5
Show member pathways
13.77 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
6
Show member pathways
13.74 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
7
Show member pathways
13.63 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
8
Show member pathways
13.61 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
9
Show member pathways
13.59 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
10
Show member pathways
13.52 EGFR ERBB2 ERBB4 HRAS KRAS NRAS
11
Show member pathways
13.47 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
12
Show member pathways
13.46 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
13
Show member pathways
13.44 EGFR ERBB2 ERBB4 HRAS KRAS NRAS
14
Show member pathways
13.41 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
15
Show member pathways
13.39 EGFR EIF2AK3 ERBB2 ERBB4 HRAS KRAS
16
Show member pathways
13.35 EGFR ERBB2 HRAS KRAS MAP2K7 NRAS
17
Show member pathways
13.32 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
18
Show member pathways
13.16 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
19
Show member pathways
13.13 EGFR HRAS KRAS MAP2K1 NRAS
20
Show member pathways
13.11 EGFR HRAS KRAS MAP2K1 NRAS
21
Show member pathways
13.1 EGFR HRAS KRAS MAP2K1 NRAS
22
Show member pathways
13.1 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
23
Show member pathways
13.09 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
24
Show member pathways
13.08 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
25
Show member pathways
13.06 HRAS KRAS MAP2K1 MAP2K7 NRAS
26
Show member pathways
13.02 EGFR HRAS KRAS MAP2K1 NRAS PIK3CA
27
Show member pathways
13.02 EGFR EIF2AK3 ERBB2 HRAS KRAS MAP2K1
28
Show member pathways
13.01 EGFR ERBB2 HRAS KRAS MAP2K1 MAP2K7
29
Show member pathways
13 EGFR ERBB2 HRAS KRAS MAP2K1 NRAS
30
Show member pathways
12.99 HRAS KRAS MAP2K1 MAP2K7 NRAS
31
Show member pathways
12.99 HRAS KRAS MAP2K1 MAP2K7 NRAS
32
Show member pathways
12.96 HRAS KRAS MAP2K1 NRAS PIK3CA
33 12.96 EGFR ERBB2 HRAS KRAS MAP2K1 NRAS
34
Show member pathways
12.94 EIF2AK3 HRAS KRAS MAP2K1 NRAS PIK3CA
35
Show member pathways
12.92 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
36
Show member pathways
12.91 HRAS KRAS MAP2K1 NRAS PIK3CA
37
Show member pathways
12.9 HRAS KRAS MAP2K1 MAP2K7 NRAS
38
Show member pathways
12.89 EGFR ERBB2 HRAS KRAS MAP2K1 NRAS
39
Show member pathways
12.88 EGFR HRAS KRAS MAP2K1 NRAS PIK3CA
40
Show member pathways
12.86 EGFR ERBB2 ERBB4 HRAS KRAS NRAS
41
Show member pathways
12.85 EGFR HRAS KRAS MAP2K1 NRAS
42
Show member pathways
12.85 ERBB2 HRAS KRAS MAP2K1 MAP2K7 NRAS
43 12.85 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
44
Show member pathways
12.83 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
45
Show member pathways
12.8 HRAS KRAS MAP2K1 PIK3CA
46
Show member pathways
12.8 EGFR HRAS KRAS MAP2K1 MAP2K7 NRAS
47
Show member pathways
12.78 EGFR HRAS KRAS MAP2K1 NRAS
48 12.78 EGFR HRAS KRAS MAP2K1 NRAS PIK3CA
49
Show member pathways
12.78 EGFR ERBB2 HRAS KRAS MAP2K1 MAP2K7
50
Show member pathways
12.74 EGFR ERBB2 HRAS KRAS NRAS PIK3CA

GO Terms for Acneiform Dermatitis

Cellular components related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.61 CYP1A1 EGFR EIF2AK3 ERBB2 HRAS KRAS
2 basal plasma membrane GO:0009925 8.8 EGFR ERBB2 ERBB4

Biological processes related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 9.97 EIF2AK3 ERBB2 HRAS KRAS MAP2K1
2 cell proliferation GO:0008283 9.93 CYP1A1 EGFR ERBB2 ERBB4 HRAS
3 protein autophosphorylation GO:0046777 9.86 EGFR EIF2AK3 ERBB2 ERBB4
4 positive regulation of protein kinase B signaling GO:0051897 9.85 EGFR ERBB2 ERBB4 PIK3CA
5 negative regulation of neuron apoptotic process GO:0043524 9.81 HRAS KRAS PIK3CA
6 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.8 EGFR ERBB2 ERBB4
7 activation of protein kinase activity GO:0032147 9.8 MAP2K1 MAP2K7 PIK3CA
8 phosphorylation GO:0016310 9.8 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
9 Ras protein signal transduction GO:0007265 9.78 HRAS KRAS NRAS
10 phosphatidylinositol phosphorylation GO:0046854 9.78 EGFR ERBB2 ERBB4 PIK3CA
11 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.77 HRAS KRAS NRAS
12 positive regulation of protein phosphorylation GO:0001934 9.77 EGFR ERBB2 ERBB4 HRAS KRAS
13 positive regulation of epithelial cell proliferation GO:0050679 9.76 EGFR ERBB2 HRAS
14 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.76 EGFR ERBB4 HRAS MAP2K1
15 cellular response to epidermal growth factor stimulus GO:0071364 9.75 EGFR ERBB2 ERBB4
16 liver development GO:0001889 9.73 CYP1A1 EGFR KRAS PIK3CA
17 peptidyl-tyrosine phosphorylation GO:0018108 9.72 EGFR ERBB2 ERBB4 MAP2K1 MAP2K7
18 positive regulation of MAP kinase activity GO:0043406 9.71 EGFR ERBB2 HRAS KRAS
19 protein phosphorylation GO:0006468 9.7 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
20 regulation of cell motility GO:2000145 9.69 EGFR ERBB2 ERBB4
21 cellular senescence GO:0090398 9.65 HRAS MAP2K1
22 regulation of long-term neuronal synaptic plasticity GO:0048169 9.65 HRAS KRAS
23 response to osmotic stress GO:0006970 9.64 EGFR MAP2K7
24 positive regulation of transcription by RNA polymerase I GO:0045943 9.63 EIF2AK3 ERBB2
25 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.62 EGFR MAP2K1
26 response to isolation stress GO:0035900 9.61 HRAS KRAS
27 negative regulation of ERBB signaling pathway GO:1901185 9.6 EGFR ERBB2
28 positive regulation of MAPK cascade GO:0043410 9.52 ERBB2 HRAS
29 ERBB2 signaling pathway GO:0038128 9.26 EGFR ERBB2 ERBB4 PIK3CA
30 MAPK cascade GO:0000165 9.17 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
31 signal transduction GO:0007165 10.1 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1

Molecular functions related to Acneiform Dermatitis according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ATP binding GO:0005524 9.95 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
2 protein kinase activity GO:0004672 9.85 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
3 protein serine/threonine kinase activity GO:0004674 9.84 EIF2AK3 MAP2K1 MAP2K7 PIK3CA
4 enzyme binding GO:0019899 9.8 CYP1A1 EGFR EIF2AK3 MAP2K7
5 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.69 EGFR ERBB2 ERBB4
6 protein phosphatase binding GO:0019903 9.62 EGFR EIF2AK3 ERBB2 MAP2K7
7 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.61 EGFR ERBB2 ERBB4
8 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.56 EGFR ERBB2 ERBB4 PIK3CA
9 protein tyrosine kinase activity GO:0004713 9.55 EGFR ERBB2 ERBB4 MAP2K1 MAP2K7
10 MAP kinase kinase activity GO:0004708 9.52 MAP2K1 MAP2K7
11 kinase activity GO:0016301 9.5 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7
12 nucleotide binding GO:0000166 9.17 EGFR ERBB2 ERBB4 HRAS KRAS MAP2K1
13 protein binding GO:0005515 10.26 CYP1A1 EGFR EIF2AK3 ERBB2 ERBB4 HRAS
14 transferase activity GO:0016740 10 EGFR EIF2AK3 ERBB2 ERBB4 MAP2K1 MAP2K7

Sources for Acneiform Dermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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