MCID: ACS001
MIFTS: 60

Acoustic Neuroma

Categories: Rare diseases, Neuronal diseases, Cancer diseases

Aliases & Classifications for Acoustic Neuroma

MalaCards integrated aliases for Acoustic Neuroma:

Name: Acoustic Neuroma 12 76 53 59 43 15 73
Vestibular Schwannoma 12 53 59 29
Cerebellopontine Angle Tumor 53 73
Acoustic Neurilemoma 53 59
Acoustic Neurinoma 53 59
Neurinoma of the Acoustic Nerve 53
Vestibular Neurilemmoma 12
Neuroma, Acoustic 44
Neuroma Acoustic 55
Acoustic Tumor 53

Characteristics:

Orphanet epidemiological data:

59
vestibular schwannoma
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12689
MeSH 44 D009464
NCIt 50 C3276
Orphanet 59 ORPHA252175
UMLS via Orphanet 74 C0027859
ICD10 via Orphanet 34 D33.3

Summaries for Acoustic Neuroma

MedlinePlus : 43 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. The tumor usually grows slowly. As it grows, it presses against the hearing and balance nerves. At first, you may have no symptoms or mild symptoms. They can include Loss of hearing on one side Ringing in ears Dizziness and balance problems The tumor can also eventually cause numbness or paralysis of the face. If it grows large enough, it can press against the brain, becoming life-threatening. Acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. Ear exams, hearing tests, and scans can show if you have it. If the tumor stays small, you may only need to have it checked regularly. If you do need treatment, surgery and radiation are options. If the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. NIH: National Institute on Deafness and Communication Disorders

MalaCards based summary : Acoustic Neuroma, also known as vestibular schwannoma, is related to neuroma and facial paralysis, and has symptoms including back pain, coughing and headache. An important gene associated with Acoustic Neuroma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). The drugs Anti-Bacterial Agents and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 A vestibular schwannoma (VS) is a benign primary intracranial tumor of the myelin-forming cells of the... more...

Related Diseases for Acoustic Neuroma

Diseases related to Acoustic Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 84)
# Related Disease Score Top Affiliating Genes
1 neuroma 31.5 BICRA NF1 NF2 TGFB1
2 facial paralysis 31.2 NF2 TGFB1
3 cerebellopontine angle tumor 12.4
4 neurofibromatosis, type iv, of riccardi 11.9
5 neurofibromatosis, type ii 11.6
6 neurofibromatosis, type i 11.3
7 schwannomatosis 1 11.0
8 benign meningioma 10.6 NF2 PCNA
9 malignant ependymoma 10.5 ERCC5 NF2
10 neurofibromatosis, familial spinal 10.4 NF1 NF2
11 neurofibrosarcoma 10.4 NF1 NF2
12 plexiform schwannoma 10.4 NF1 NF2
13 immature cataract 10.4 NF1 NF2
14 plexiform neurofibroma 10.4 NF1 NF2
15 atypical neurofibroma 10.4 NF1 NF2
16 cerebrospinal fluid leak 10.3
17 headache 10.3
18 cerebrooculofacioskeletal syndrome 1 10.3 ERCC2 ERCC5
19 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
20 amyloid tumor 10.3 NF1 NF2
21 spinal meningioma 10.2 NF1 NF2
22 spinal canal and spinal cord meningioma 10.2 NF1 NF2
23 meningitis 10.2
24 glioma 10.2
25 neurilemmomatosis 10.2 NF1 NF2
26 hydrocephalus 10.1
27 optic nerve neoplasm 10.1 NF1 NF2
28 spinal cord ependymoma 10.1 AQP1 NF1 NF2
29 myoclonus and ataxia 10.0
30 sensorineural hearing loss 10.0
31 glioblastoma 10.0
32 depression 10.0
33 aneurysm 10.0
34 meningioma, familial 10.0 NF1 NF2 PCNA
35 exophthalmos 10.0 NF1 TGFB1
36 xeroderma pigmentosum, complementation group g 10.0 ERCC4 ERCC5
37 glioma susceptibility 1 10.0
38 anxiety 10.0
39 mastoiditis 10.0
40 arachnoiditis 10.0
41 glioblastoma multiforme 10.0
42 cerebritis 10.0
43 herpes simplex 10.0
44 cockayne syndrome a 9.9 ERCC2 ERCC4 ERCC5
45 cerebro-oculo-facio-skeletal syndrome 9.9 ERCC2 ERCC4 ERCC5
46 xeroderma pigmentosum, complementation group f 9.9 ERCC2 ERCC4 ERCC5
47 cockayne syndrome 9.9 ERCC2 ERCC4 ERCC5
48 autosomal genetic disease 9.8 ERCC2 NF1 NF2
49 deafness, unilateral 9.8
50 otitis media 9.8

Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to Acoustic Neuroma

Symptoms & Phenotypes for Acoustic Neuroma

UMLS symptoms related to Acoustic Neuroma:


back pain, coughing, headache, pain, sciatica, seizures, snoring, syncope, tinnitus, tremor, chronic pain, sore throat, vertigo/dizziness, equilibration disorder, sleeplessness

GenomeRNAi Phenotypes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.78 LIG1 LIG4 PCNA AQP1 ERCC4 TGFB1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.78 ERCC5 LIG1 LIG4 PCNA AQP1 RAD51
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.7 LIG1 LIG4 PCNA RAD51 ERCC2 ERCC4
4 Synthetic lethal with cisplatin GR00101-A-1 8.96 NF2 RAD51

MGI Mouse Phenotypes related to Acoustic Neuroma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.23 LIG4 ERCC2 NF1 ERCC4 ERCC5 ABCA2
2 endocrine/exocrine gland MP:0005379 10.08 ERCC2 LIG4 NF1 LIG1 AQP1 TGFB1
3 homeostasis/metabolism MP:0005376 10.06 LIG1 AQP1 ERCC2 LIG4 NF1 ERCC5
4 hematopoietic system MP:0005397 10.03 AQP1 ERCC2 LIG4 NF1 ERCC5 LIG1
5 immune system MP:0005387 9.97 ERCC2 LIG4 NF1 ERCC5 LIG1 TGFB1
6 mortality/aging MP:0010768 9.93 LIG4 ERCC2 NF1 ERCC4 ERCC5 ABCA2
7 integument MP:0010771 9.8 LIG1 ERCC2 NF1 ERCC5 TGFB1 NF2
8 liver/biliary system MP:0005370 9.8 LIG4 NF1 ERCC4 ERCC5 LIG1 TGFB1
9 neoplasm MP:0002006 9.43 ERCC2 LIG4 NF1 LIG1 TGFB1 NF2
10 reproductive system MP:0005389 9.17 ERCC2 LIG4 ABCA2 AQP1 TGFB1 NF2

Drugs & Therapeutics for Acoustic Neuroma

Drugs for Acoustic Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 61)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
2 Anti-Infective Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
3 Gentamicins Phase 4,Not Applicable
4
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6 Antiemetics Phase 3
7 Anti-Inflammatory Agents Phase 3,Phase 2
8 Antineoplastic Agents, Hormonal Phase 3,Not Applicable
9 Autonomic Agents Phase 3
10 Gastrointestinal Agents Phase 3,Not Applicable
11 glucocorticoids Phase 3
12 Hormone Antagonists Phase 3
13 Hormones Phase 3
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
15 Methylprednisolone acetate Phase 3
16 Methylprednisolone Hemisuccinate Phase 3
17 Neuroprotective Agents Phase 3
18 Peripheral Nervous System Agents Phase 3,Phase 2
19 Prednisolone acetate Phase 3
20 Prednisolone hemisuccinate Phase 3
21 Prednisolone phosphate Phase 3
22 Protective Agents Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 6442177
25
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 5284616 6436030 46835353
27
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
28
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
29
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
30
Lactitol Investigational Phase 2 585-86-4 3871
31 Protein Kinase Inhibitors Phase 2,Early Phase 1
32 Angiogenesis Inhibitors Phase 2,Phase 1
33 Angiogenesis Modulating Agents Phase 2,Phase 1
34 Antibodies Phase 2
35 Antibodies, Monoclonal Phase 2
36 Immunoglobulins Phase 2
37 Antibiotics, Antitubercular Phase 2,Early Phase 1
38 Antifungal Agents Phase 2,Early Phase 1
39 Immunosuppressive Agents Phase 2,Early Phase 1
40 Endostatins Phase 2 71581480
41 Analgesics Phase 2
42 Analgesics, Non-Narcotic Phase 2
43 Anti-Inflammatory Agents, Non-Steroidal Phase 2
44 Antipyretics Phase 2
45 Antirheumatic Agents Phase 2
46 Cyclooxygenase Inhibitors Phase 2
47 Fibrinolytic Agents Phase 2
48 Platelet Aggregation Inhibitors Phase 2
49
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
50
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394

Interventional clinical trials:

(show top 50) (show all 55)
# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Recruiting NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
5 Vestibular Schwannoma - Radiosurgery or Expectation: V-REX. Recruiting NCT02249572 Phase 2, Phase 3
6 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
7 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
8 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2 RAD001
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2 Endostatin
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
11 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2 Everolimus (RAD001) , Afinitor®
12 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
13 RGD PET/MRI in Sporadic Vestibular Schwannoma Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT02129647 Phase 2 Axitinib
16 Study of Aspirin in Patients With Vestibular Schwannoma Recruiting NCT03079999 Phase 2 Aspirin;Placebo
17 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
18 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Recruiting NCT02934256 Phase 2 Icotinib
19 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2 Bevacizumab
20 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
21 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Active, not recruiting NCT02831257 Phase 2 AZD2014
22 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
23 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
24 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
25 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
26 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
27 Concentration and Activity of Lapatinib in Vestibular Schwannomas Unknown status NCT00863122 Early Phase 1 lapatinib
28 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231 Not Applicable
29 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
30 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896 Not Applicable gentamicin
31 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099 Not Applicable
32 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
33 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
34 A Family Study of Adults With Glioma Completed NCT00339352
35 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
36 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560 Not Applicable
37 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Recruiting NCT02275325 Not Applicable
38 Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma Recruiting NCT02282917 Early Phase 1 AR-42
39 Vestibular Outcomes in Vestibular Schwannoma Recruiting NCT03346889
40 Subtotal Resection of Large Acoustic Neuromas With Possible Stereotactic Radiation Therapy Recruiting NCT01129687
41 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726 Not Applicable
42 Consequence of Unilateral Vestibular Loss on Visual Abilities Recruiting NCT03581331 Not Applicable
43 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Recruiting NCT03520829
44 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Recruiting NCT02811718 Not Applicable
45 Gamma Knife Radiosurgery vs Initial Conservative Treatment for Vestibular Schwannoma Patients With Preserved Hearing, a Prospective Randomized Study Active, not recruiting NCT01938677 Not Applicable
46 Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas Active, not recruiting NCT01880749 Early Phase 1 RAD001
47 Natural History Study of Patients With Neurofibromatosis Type 2 Active, not recruiting NCT00598351
48 Evaluating the Pre-Positioning Frame for Robotic Acoustic Neuroma Removal Surgery Not yet recruiting NCT03057678 Not Applicable
49 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Not yet recruiting NCT02948790 Not Applicable
50 Response Prediction After GKS in Patients With Vestibular Schwannoma Using DCE MR Imaging Not yet recruiting NCT03097822

Search NIH Clinical Center for Acoustic Neuroma

Cochrane evidence based reviews: neuroma, acoustic

Genetic Tests for Acoustic Neuroma

Genetic tests related to Acoustic Neuroma:

# Genetic test Affiliating Genes
1 Vestibular Schwannoma 29

Anatomical Context for Acoustic Neuroma

MalaCards organs/tissues related to Acoustic Neuroma:

41
Brain, Testes, Bone, Temporal Lobe, Pituitary, Lung, Eye

Publications for Acoustic Neuroma

Articles related to Acoustic Neuroma:

(show top 50) (show all 604)
# Title Authors Year
1
Risk of posterior semicircular canal trauma when using a retrosigmoid approach for acoustic neuroma surgery and role of endoscopy: An imaging study. ( 29493720 )
2018
2
Acoustic Neuroma Treated with Stereotactic Radiosurgery: Follow-up of 335 Patients. ( 29715569 )
2018
3
Patient Decision Making in Vestibular Schwannoma: A Survey of the Acoustic Neuroma Association. ( 29436268 )
2018
4
Increased sensibility to acute acoustic and blast trauma among patients with acoustic neuroma. ( 29184217 )
2018
5
Cochlea-sparing acoustic neuroma treatment with 4I8 radiation therapy. ( 29904732 )
2018
6
Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery. ( 29889284 )
2018
7
Acoustic neuroma quality of life: are we missing the point? ( 29948270 )
2018
8
The medium and long-term effect of electrophysiologic monitoring on the facial nerve function in minimally invasive surgery treating acoustic neuroma. ( 29563978 )
2018
9
Long-term outcome after Gamma Knife radiosurgery for acoustic neuroma of all Koos grades: a single-center study. ( 29498575 )
2018
10
Ophthalmic Complications Following Acoustic Neuroma Resection. ( 29253289 )
2018
11
The impact of acoustic neuroma on long-term quality-of-life outcomes in the United Kingdom. ( 29330600 )
2018
12
Transcanal Transpromontorial Acoustic Neuroma Surgery: Results and Facial Nerve Outcomes. ( 29227438 )
2018
13
Operative Mortality Rates of Acoustic Neuroma Surgery: A National Cancer Database Analysis. ( 28187056 )
2017
14
Validation of the facial dysfunction domain of the Penn Acoustic Neuroma Quality-of-Life (PANQOL) Scale. ( 28391530 )
2017
15
The Top 50 Most-Cited Articles on Acoustic Neuroma. ( 29288105 )
2017
16
Evaluation of Auditory Pathways Using DTI in Patients Treated with Gamma Knife Radiosurgery for Acoustic Neuroma: AA Preliminary Report. ( 28258282 )
2017
17
Postoperative Headache after Undergoing Acoustic Neuroma Surgery via the Retrosigmoid Approach. ( 29021412 )
2017
18
Influencing Factors Analysis of Facial Nerve Function after the Microsurgical Resection of Acoustic Neuroma. ( 28264236 )
2017
19
Conservative treatment of vestibular schwannoma: growth and Penn Acoustic Neuroma Quality of Life scale in French language. ( 28872162 )
2017
20
Multistep translation and cultural adaptation of the Penn acoustic neuroma quality-of-life scale for German-speaking patients. ( 28861705 )
2017
21
Impact of insurance status and race on receipt of treatment for acoustic neuroma: A national cancer database analysis. ( 28343920 )
2017
22
Probabilistic Multiple-Bias Modeling Applied to the Canadian Data From the Interphone Study of Mobile Phone Use and Risk of Glioma, Meningioma, Acoustic Neuroma, and Parotid Gland Tumors. ( 28535174 )
2017
23
Peripheral nerve function estimation by linear model of multi-CMAP responses for surgical intervention in acoustic neuroma surgery. ( 29192065 )
2017
24
A systematic review about the position-related complications of acoustic neuroma surgery via suboccipital retrosigmoid approach: Sitting versus lateral. ( 28761510 )
2017
25
Complications of the Middle Cranial Fossa Approach for Acoustic Neuroma Removal. ( 28816690 )
2017
26
Validation of the Penn Acoustic Neuroma Quality-of-Life Scale (PANQOL) for Spanish-Speaking Patients. ( 28116984 )
2017
27
Resection planning for robotic acoustic neuroma surgery. ( 28612038 )
2017
28
Acoustic Neuroma (Vestibular Schwannoma) ( 29262098 )
2017
29
Signs and Symptoms of Acoustic Neuroma at Initial Presentation: An Exploratory Analysis. ( 29348989 )
2017
30
Dorsal displacement of the facial nerve in acoustic neuroma surgery: clinical features and surgical outcomes of 21 consecutive dorsal pattern cases. ( 26621676 )
2016
31
Acoustic neuroma as first sign of inner ear functional disorders. ( 27935543 )
2016
32
SU-F-T-612: Investigation of Acoustic Neuroma Planning for Stereotactic Radiosurgery Utilizing Linac-Based Cone Collimators. ( 28046447 )
2016
33
In vivo visualization of the facial nerve in patients with acoustic neuroma using diffusion tensor imaging-based fiber tracking. ( 26722859 )
2016
34
The Persistence of Tinnitus after Acoustic Neuroma Surgery. ( 27095048 )
2016
35
Summary and consensus in 7th International Conference on acoustic neuroma: An update for the management of sporadic acoustic neuromas. ( 29204572 )
2016
36
Acoustic Neuroma Mimicking Orofacial Pain: A Unique Case Report. ( 28053796 )
2016
37
Surgical treatment of acoustic neuroma: Outcomes and indications. ( 27330426 )
2016
38
Suspected Acoustic Neuroma Demyelinating Lesions. ( 27579562 )
2016
39
Suspected Acoustic Neuroma Demyelinating Lesions. ( 28005807 )
2016
40
Hearing preservation in acoustic neuroma resection: Analysis of petrous bone measurement and intraoperative application. ( 28144470 )
2016
41
Change in tinnitus after acoustic neuroma removal using a translabyrinthine approach. A Prospective study. ( 27067182 )
2016
42
The Fully Endoscopic Acoustic Neuroma Surgery. ( 27565388 )
2016
43
SU-F-T-611: Critical Analysis and Efficacy of Linac Based (Beam Modulator) and Cyberknife Treatment Plans for Acoustic Neuroma/schwannoma. ( 28047111 )
2016
44
Evolution of Patients With Immediate Complete Facial Paralysis Secondary to Acoustic Neuroma Surgery. ( 26719351 )
2016
45
Risk Factors of Acoustic Neuroma: Systematic Review and Meta-Analysis. ( 26996581 )
2016
46
Multifactor Influences of Shared Decision-Making in Acoustic Neuroma Treatment. ( 27930442 )
2016
47
Self-reported symptoms and patient experience: A British Acoustic Neuroma Association survey. ( 26523744 )
2015
48
Electroacupuncture therapy for abducent palsy after acoustic neuroma surgery. ( 25739636 )
2015
49
Abducens nerve schwannoma in cerebellopontine angle mimicking acoustic neuroma. ( 25759926 )
2015
50
Unilateral acoustic neuromas in childhood without evidence of neurofibromatosis: experience in 10 patients at a single institute. ( 27593791 )
2015

Variations for Acoustic Neuroma

Expression for Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for Acoustic Neuroma

Pathways related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.7 ERCC2 ERCC4 ERCC5 LIG1 LIG4 PCNA
2
Show member pathways
12.45 ERCC2 ERCC4 ERCC5 LIG1 PCNA
3 12.13 ERCC2 ERCC4 LIG4 PCNA RAD51
4
Show member pathways
12.11 ERCC2 ERCC4 ERCC5 LIG1 LIG4 PCNA
5
Show member pathways
11.93 ERCC4 PCNA RAD51
6
Show member pathways
11.16 ERCC2 ERCC4 ERCC5 LIG1 LIG4 PCNA
7 10.95 NF1 TGFB1
8 10.87 PCNA RAD51
9 10.83 ERCC2 ERCC4

GO Terms for Acoustic Neuroma

Cellular components related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.7 AQP1 ERCC2 ERCC4 ERCC5 LIG1 LIG4
2 transcription factor TFIID complex GO:0005669 9.37 ERCC2 ERCC4
3 condensed chromosome GO:0000793 9.32 LIG4 RAD51
4 replication fork GO:0005657 9.26 PCNA RAD51
5 holo TFIIH complex GO:0005675 9.16 ERCC2 ERCC5
6 nuclear chromosome, telomeric region GO:0000784 8.92 ERCC4 LIG4 PCNA RAD51

Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 cell proliferation GO:0008283 9.92 ERCC2 LIG4 PCNA TGFB1
2 DNA replication GO:0006260 9.82 LIG1 LIG4 PCNA
3 response to hypoxia GO:0001666 9.82 ERCC2 NF1 TGFB1
4 DNA recombination GO:0006310 9.78 LIG1 LIG4 RAD51
5 positive regulation of fibroblast proliferation GO:0048146 9.71 AQP1 LIG4 TGFB1
6 cellular response to UV GO:0034644 9.7 AQP1 ERCC4 PCNA
7 cellular response to DNA damage stimulus GO:0006974 9.7 ERCC2 ERCC4 ERCC5 LIG1 LIG4 PCNA
8 response to UV GO:0009411 9.69 ERCC2 ERCC4 ERCC5
9 liver regeneration GO:0097421 9.68 PCNA TGFB1
10 DNA biosynthetic process GO:0071897 9.68 LIG1 LIG4
11 mismatch repair GO:0006298 9.67 LIG1 PCNA
12 spinal cord development GO:0021510 9.67 ERCC2 NF1
13 cellular response to ionizing radiation GO:0071479 9.67 RAD51 TGFB1
14 nucleotide-excision repair GO:0006289 9.67 ERCC2 ERCC4 ERCC5
15 global genome nucleotide-excision repair GO:0070911 9.66 ERCC2 ERCC4
16 cellular response to dexamethasone stimulus GO:0071549 9.66 AQP1 TGFB1
17 replication fork processing GO:0031297 9.65 PCNA RAD51
18 nucleotide-excision repair, preincision complex assembly GO:0006294 9.65 ERCC2 ERCC5
19 nucleotide-excision repair, DNA gap filling GO:0006297 9.65 LIG1 LIG4 PCNA
20 negative regulation of MAPK cascade GO:0043409 9.64 NF1 NF2
21 cell-cell junction organization GO:0045216 9.63 NF2 TGFB1
22 negative regulation of DNA replication GO:0008156 9.63 NF2 TGFB1
23 nucleotide-excision repair, DNA incision, 3-to lesion GO:0006295 9.63 ERCC2 ERCC4 ERCC5
24 negative regulation of cell-matrix adhesion GO:0001953 9.62 NF1 NF2
25 nucleotide-excision repair, DNA incision GO:0033683 9.62 ERCC2 ERCC4 ERCC5 PCNA
26 negative regulation of cell-cell adhesion GO:0022408 9.61 NF2 TGFB1
27 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.61 ERCC2 ERCC4 ERCC5
28 lens fiber cell differentiation GO:0070306 9.6 NF2 TGFB1
29 V(D)J recombination GO:0033151 9.59 LIG1 LIG4
30 DNA ligation involved in DNA repair GO:0051103 9.58 LIG1 LIG4
31 response to cholesterol GO:0070723 9.58 ABCA2 TGFB1
32 UV protection GO:0009650 9.58 ERCC2 ERCC4 ERCC5
33 lagging strand elongation GO:0006273 9.57 LIG1 LIG4
34 hair follicle maturation GO:0048820 9.56 ERCC2 NF1
35 nucleotide-excision repair, DNA incision, 5-to lesion GO:0006296 9.56 ERCC2 ERCC4 ERCC5 PCNA
36 negative regulation of neuroblast proliferation GO:0007406 9.55 NF1 TGFB1
37 DNA ligation GO:0006266 9.54 LIG1 LIG4 PCNA
38 transcription-coupled nucleotide-excision repair GO:0006283 9.35 ERCC2 ERCC4 ERCC5 LIG1 PCNA
39 DNA repair GO:0006281 9.17 ERCC2 ERCC4 ERCC5 LIG1 LIG4 PCNA

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.98 ERCC2 ERCC4 ERCC5 LIG1 LIG4 PCNA
2 identical protein binding GO:0042802 9.85 AQP1 ERCC4 PCNA RAD51 TGFB1
3 protein C-terminus binding GO:0008022 9.56 ERCC2 ERCC4 LIG4 RAD51
4 single-stranded DNA binding GO:0003697 9.54 ERCC4 ERCC5 RAD51
5 DNA polymerase binding GO:0070182 9.4 PCNA RAD51
6 DNA ligase (ATP) activity GO:0003910 9.32 LIG1 LIG4
7 DNA ligase activity GO:0003909 9.16 LIG1 LIG4
8 endodeoxyribonuclease activity GO:0004520 9.13 ERCC4 ERCC5 RAD51
9 protein N-terminus binding GO:0047485 8.92 ERCC2 ERCC4 ERCC5 TGFB1

Sources for Acoustic Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
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46 MGI
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54 NINDS
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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