MCID: ACS001
MIFTS: 56

Acoustic Neuroma

Categories: Cancer diseases, Ear diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acoustic Neuroma

MalaCards integrated aliases for Acoustic Neuroma:

Name: Acoustic Neuroma 12 73 20 58 42 15 70
Vestibular Schwannoma 12 20 58 15
Cerebellopontine Angle Tumor 20 70
Acoustic Neurilemoma 20 58
Acoustic Neurinoma 20 58
Neurinoma of the Acoustic Nerve 20
Vestibular Neurilemmoma 12
Neuroma, Acoustic 44
Neuroma Acoustic 54
Acoustic Tumor 20

Characteristics:

Orphanet epidemiological data:

58
vestibular schwannoma
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000;

Classifications:

Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12689
MeSH 44 D009464
NCIt 50 C3276
SNOMED-CT 67 269643009
ICD10 via Orphanet 33 D33.3
UMLS via Orphanet 71 C0027859
Orphanet 58 ORPHA252175
UMLS 70 C0027859 C0474740

Summaries for Acoustic Neuroma

MedlinePlus : 42 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. The tumor usually grows slowly. As it grows, it presses against the hearing and balance nerves. At first, you may have no symptoms or mild symptoms. They can include Loss of hearing on one side Ringing in ears Dizziness and balance problems The tumor can also eventually cause numbness or paralysis of the face. If it grows large enough, it can press against the brain, becoming life-threatening. Acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. Ear exams, hearing tests, and scans can show if you have it. If the tumor stays small, you may only need to have it checked regularly. If you do need treatment, surgery and radiation are options. If the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. NIH: National Institute on Deafness and Communication Disorders

MalaCards based summary : Acoustic Neuroma, also known as vestibular schwannoma, is related to intracranial meningioma and neurofibromatosis, and has symptoms including seizures, tremor and back pain. An important gene associated with Acoustic Neuroma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Chks in Checkpoint Regulation. The drugs Bevacizumab and Lapatinib have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and pituitary, and related phenotypes are homeostasis/metabolism and behavior/neurological

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs. Orpha Number: 252175 Definition Vestibular schwannoma is a rare tumor of the posterior fossa originating in the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve that can be benign, small, slow growing and asymptomatic or large, faster growing and aggressive and potentially fatal, presenting with symptoms of hearing and balance impairment, vertigo, ataxia, headache and fifth, sixth or seventh cranial nerve dysfunction and facial numbness.

Wikipedia : 73 A vestibular schwannoma (VS) is a benign primary intracranial tumor of the myelin-forming cells of the... more...

Related Diseases for Acoustic Neuroma

Diseases related to Acoustic Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 381)
# Related Disease Score Top Affiliating Genes
1 intracranial meningioma 31.4 PCNA MGMT
2 neurofibromatosis 31.2 RDX NF2 NF1
3 neuroma 31.2 TGFB1 NF2 NF1 MGMT ERCC2 BICRA
4 neurilemmomatosis 30.4 NF2 NF1 LZTR1
5 communicating hydrocephalus 30.3 TGFB1 AQP4 AQP1
6 obstructive hydrocephalus 30.3 NF2 NF1 AQP4 AQP1
7 olfactory groove meningioma 30.2 NF2 LZTR1
8 pathologic nystagmus 30.2 RDX MSN EZR
9 neurofibromatosis, type ii 30.2 RDX NF2 NF1 MSN EZR
10 meningioma, familial 30.1 RDX PCNA NF2 NF1 MSN EZR
11 brain cancer 29.6 NF2 NF1 MGMT AQP4
12 neurilemmoma 29.6 RDX NF2 NF1 MSN MIR96 LZTR1
13 pilocytic astrocytoma 29.2 NF1 MGMT ERBB3
14 neurofibromatosis, type iv, of riccardi 11.2
15 neurofibromatosis, type i 11.2
16 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.9
17 facial paralysis 10.8
18 sensorineural hearing loss 10.8
19 branchiootic syndrome 1 10.7
20 headache 10.6
21 hydrocephalus 10.6
22 secretory meningioma 10.6
23 lymphoplasmacyte-rich meningioma 10.6
24 cerebrospinal fluid leak 10.6
25 trigeminal neuralgia 10.4
26 ataxia and polyneuropathy, adult-onset 10.4
27 cerebellopontine angle tumor 10.4
28 xeroderma pigmentosum-cockayne syndrome complex 10.4 ERCC4 ERCC2
29 meniere disease 10.3
30 glioma 10.3
31 glial tumor 10.3
32 cerebro-oculo-facio-skeletal syndrome 10.3 ERCC4 ERCC2
33 otosclerosis 10.3
34 meningitis 10.3
35 xeroderma pigmentosum, complementation group d 10.3 ERCC4 ERCC2 APEX1
36 glioblastoma 10.3
37 47,xyy 10.3
38 sudden sensorineural hearing loss 10.3
39 xeroderma pigmentosum, complementation group g 10.3 ERCC4 ERCC2 APEX1
40 epidermoid cysts 10.2
41 sarcoma 10.2
42 normal pressure hydrocephalus 10.2
43 spindle cell sarcoma 10.2
44 subependymoma 10.2 AQP4 AQP1
45 myoclonus and ataxia 10.2
46 herpes simplex 10.2
47 bacterial meningitis 10.2
48 paresthesia 10.2
49 epithelioid neurofibroma 10.2 NF2 NF1
50 intraorbital meningioma 10.2 NF2 LZTR1

Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to Acoustic Neuroma

Symptoms & Phenotypes for Acoustic Neuroma

UMLS symptoms related to Acoustic Neuroma:


seizures; tremor; back pain; headache; syncope; tinnitus; pain; chronic pain; sciatica; snoring; sore throat; coughing; vertigo/dizziness; equilibration disorder; sleeplessness

MGI Mouse Phenotypes related to Acoustic Neuroma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ABCA2 APEX1 AQP1 AQP4 AQP6 BRIP1
2 behavior/neurological MP:0005386 10.29 ABCA2 AQP1 AQP4 BRIP1 ERBB3 ERCC2
3 growth/size/body region MP:0005378 10.29 ABCA2 APEX1 AQP1 AQP4 ERBB3 ERCC2
4 endocrine/exocrine gland MP:0005379 10.24 APEX1 AQP1 AQP4 BRIP1 ERBB3 ERCC2
5 mortality/aging MP:0010768 10.24 ABCA2 APEX1 AQP1 AQP4 ERBB3 ERCC2
6 immune system MP:0005387 10.17 APEX1 AQP1 AQP4 ERBB3 ERCC2 EZR
7 nervous system MP:0003631 10 ABCA2 AQP1 AQP4 BRIP1 ERBB3 ERCC2
8 liver/biliary system MP:0005370 9.95 APEX1 BRIP1 ERCC4 NF1 NF2 RDX
9 neoplasm MP:0002006 9.92 APEX1 BRIP1 ERBB3 ERCC2 MGMT NF1
10 reproductive system MP:0005389 9.85 ABCA2 APEX1 AQP1 BRIP1 ERCC2 NF1
11 respiratory system MP:0005388 9.56 AQP1 AQP4 ERBB3 MGMT MSN NF1
12 vision/eye MP:0005391 9.32 AQP1 AQP4 AQP6 BRIP1 ERCC2 EZR

Drugs & Therapeutics for Acoustic Neuroma

Drugs for Acoustic Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 52)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3
2
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
3
Sirolimus Approved, Investigational Phase 2 53123-88-9 6436030 5284616
4
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
5
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
6
Crizotinib Approved Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
7
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
8
Nimodipine Approved, Investigational Phase 2 66085-59-4 4497
9 Angiogenesis Inhibitors Phase 2
10 Antineoplastic Agents, Immunological Phase 2
11 Immunoglobulins Phase 2
12 Antibodies Phase 2
13 Immunoglobulins, Intravenous Phase 2
14 Antibodies, Monoclonal Phase 2
15 Endostatins Phase 2 71581480
16 Mitogens Phase 2
17 Endothelial Growth Factors Phase 2
18 Anti-Inflammatory Agents Phase 2
19 Analgesics, Non-Narcotic Phase 2
20 Analgesics Phase 2
21 Fibrinolytic Agents Phase 2
22 Antirheumatic Agents Phase 2
23 Cyclooxygenase Inhibitors Phase 2
24 Anti-Inflammatory Agents, Non-Steroidal Phase 2
25 Antipyretics Phase 2
26 Platelet Aggregation Inhibitors Phase 2
27 Protein Kinase Inhibitors Phase 2
28 Immunosuppressive Agents Phase 2
29 Immunologic Factors Phase 2
30 Pharmaceutical Solutions Phase 2
31 Vasodilator Agents Phase 2
32 Gelatin Sponge, Absorbable Phase 2
33 Hormones Phase 2
34 calcium channel blockers Phase 2
35 Antihypertensive Agents Phase 2
36 Calcium, Dietary Phase 2
37
Calcium Nutraceutical Phase 2 7440-70-2 271
38
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
39
Triamcinolone Approved, Vet_approved Phase 1 124-94-7 31307
40 Alkylating Agents Phase 1
41 Hormone Antagonists Phase 1
42 Triamcinolone diacetate Phase 1
43 glucocorticoids Phase 1
44 triamcinolone acetonide Phase 1
45 Triamcinolone hexacetonide Phase 1
46
tannic acid Approved 1401-55-4
47
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
48
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
49 Neuromuscular Nondepolarizing Agents
50 Neuromuscular Blocking Agents

Interventional clinical trials:

(show top 50) (show all 68)
# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With Definite Remaining Vestibular Function Withdrawn NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function Withdrawn NCT02415257 Phase 4 Gentamicin
3 Randomized Comparison of Steretotactic Radiosurgery and Hypofractionated Steretotactic Radiotherapy in the Treatment of Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Kan tumorvækst Forudsiges Ved RGD-PET/MR af Vestibularis Schwannomer? Unknown status NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
5 Icotinib Hydrochloride Tablets Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
6 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
7 Phase 2 Study of Bevacizumab in Children and Adults With Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma Completed NCT01207687 Phase 2
8 Recombinant Human Endostatin Injection Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors by Continuous Intravenous Pumping Completed NCT02104323 Phase 2 Endostatin
9 A Single Arm, Single Center, Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Completed NCT01490476 Phase 2 RAD001
10 Open-label, Phase 2 Study of Bevacizumab in Children and Young Adults With Neurofibromatosis 2 and Progressive Vestibular Schwannomas That Are Poor Candidates for Standard Treatment With Surgery or Radiation Completed NCT01767792 Phase 2 Bevacizumab
11 Phase II Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Completed NCT02129647 Phase 2 Axitinib
12 Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas Completed NCT01125046 Phase 2
13 Phase II Study of Lapatinib in Children and Adults With Neurofibromatosis Type 2(NF2) and NF2-related Tumors Completed NCT00973739 Phase 2 Lapatinib
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Prospective, Randomized, Placebo-Controlled Phase II Trial of Aspirin for Vestibular Schwannomas Recruiting NCT03079999 Phase 2 Aspirin;Placebo
16 Open-label, Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT04283669 Phase 2 Crizotinib
17 Phase 2 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
18 Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2) Recruiting NCT04374305 Phase 2 Brigatinib
19 A Single Arm, Monocenter Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
20 Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560 Not yet recruiting NCT04351373 Phase 2 intravenous fluorescein sodium
21 Intraoperative Application of Nimodipine to the Facial and Cochlear Nerves During Vestibular Schwannoma Resection to Avoid Spasm-related Postoperative Facial Paralysis and Deafness - a Prospective Randomized Pilot Study Not yet recruiting NCT04801953 Phase 2 NiMODipine Injectable Solution
22 A Phase II Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
23 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
24 Triamcinolone Acetonide Levels in Cochlear Perilymph, Lateral Canal and CSF in Patients With Vestibular Schwannomas Recruiting NCT04658836 Phase 1 Triamcinolone Acetonide 40mg/mL
25 Phase I Trial of Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma (Acoustic Neuroma) Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
26 Evaluation of the Influence of Psychological Factors on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT01743248
27 Evaluation of Endoscopic-assisted Microsurgical Removal of Cerebellopontine Angle Lesions Unknown status NCT03228511
28 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma : Feasibility Study Unknown status NCT02948790
29 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Unknown status NCT03520829
30 Saccular Dilatation, Endolymphatic Hydrops and Vestibular Schwannoma : is Vertigo Really Correlated to the Tumor ? A Retrospective Study Based on FIESTA-C Sequence Using a 3 Tesla MRI Unknown status NCT03593577
31 Consequence of Unilateral Vestibular Loss on Visual Abilities Unknown status NCT03581331
32 Assessment of the Preoperative Vestibular Rehabilitation Effectiveness on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT02275325
33 Response Prediction After Gamma Knife Surgery (GKS) in Patients With Vestibular Schwannoma Using Dynamic Contrast-Enhanced (DCE) MR Imaging Unknown status NCT03097822
34 Vegetative Monitoring During Brainstem-associated Surgery Unknown status NCT03666507
35 NF2 Natural History Consortium Unknown status NCT00004483
36 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
37 Vestibular Evaluation Before and After Treatment of Vestibular Schwannoma. Comparison of Gamma Knife Radiosurgery and Microsurgical Resection Completed NCT03670589
38 Intraoperative Motor Evoked Potential Monitoring of Facial Nerve in Patients Undergoing Cerbellopontine Angle Tumer Resection Using Partial Versus no Neuromuscular Block Completed NCT04148534 Muscle Relaxants, Non Depolarizing
39 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099
40 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma With Pretreatment Prehabituation by Chemical Vestibular Ablation Completed NCT02963896 gentamicin
41 Assessment of Visual Sensitivity, Psychiatric Profile and Quality of Life Following Vestibular Schwannoma Surgery in Patients Prehabituated by Chemical Vestibular Ablation Completed NCT03638310
42 Exploration and Estimation of Intratumoral Concentration and Activity of Lapatinib in Vivo in Vestibular Schwannomas Completed NCT00863122 Early Phase 1 lapatinib
43 Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas Completed NCT01880749 Early Phase 1 RAD001
44 Whole Exome Sequencing (WES) of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Completed NCT03210285
45 Recovery of Visual Acuity in Vestibular Deficits Completed NCT00411216
46 Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base Recruiting NCT04249921
47 Clinical and Radiological Evaluation of Acoustic Neuromas With Spontaneous Shrinkage Recruiting NCT03970681
48 Acoustic Neuroma: Assessing the Quality of Life by the Scale PANQOL of Patients Operated or Supervised Recruiting NCT04004377
49 Cochlear Implantation During Vestibular Schwannoma Removal or During Labyrinthectomy Surgery for Treatment of Meniere's Disease Recruiting NCT03795675
50 Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results - a Pilot Study Recruiting NCT03745560

Search NIH Clinical Center for Acoustic Neuroma

Cochrane evidence based reviews: neuroma, acoustic

Genetic Tests for Acoustic Neuroma

Anatomical Context for Acoustic Neuroma

MalaCards organs/tissues related to Acoustic Neuroma:

40
Brain, Bone, Pituitary, Endothelial, Temporal Lobe, Eye, Breast

Publications for Acoustic Neuroma

Articles related to Acoustic Neuroma:

(show top 50) (show all 5042)
# Title Authors PMID Year
1
Manual segmentation versus semi-automated segmentation for quantifying vestibular schwannoma volume on MRI. 61 42
32676869 2020
2
Management of transmodiolar and transmacular cochleovestibular schwannomas with and without cochlear implantation. 42
33044580 2021
3
MRI based volumetric measurements of vestibular schwannomas in patients with neurofibromatosis type 2: comparison of three different software tools. 42
32665659 2020
4
BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. 54 61
19937367 2010
5
Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis. 54 61
20195187 2010
6
Pathogenesis of vestibular schwannoma in ring chromosome 22. 54 61
19772601 2009
7
[Expression of S518 phosphorylated Merlin and its interaction with CD44 in vestibular schwannoma]. 61 54
19141242 2008
8
Compensative shuttling of merlin to phosphorylation on serine 518 in vestibular schwannoma. 61 54
17989580 2008
9
Erythropoietin and erythropoietin receptor expression in vestibular schwannoma: potential role in tumor progression. 54 61
17429338 2007
10
[Neurotrophic factor expression in vestibular schwannoma. An overview]. 61 54
16612755 2006
11
[Expression and localization of merlin in vestibular schwannoma]. 61 54
17007372 2006
12
Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. 54 61
15850583 2005
13
Co-expression of transforming growth factor-beta1 and glial cell line-derived neurotrophic factor in vestibular schwannoma. 61 54
15129118 2004
14
Gene discovery using a human vestibular schwannoma cDNA library constructed from a patient with neurofibromatosis type 2 (NF2). 61 54
12646839 2003
15
Immunolocalization of erythropoietin and erythropoietin receptor in vestibular schwannoma. 54 61
11349767 2001
16
Establishment of primary vestibular schwannoma cultures from neurofibromatosis type-2 patients. 61 54
10024671 1999
17
Immunoblotting analysis of schwannomin/merlin in human schwannomas. 61 54
9752976 1998
18
Nerve growth factor receptor expression in heterotransplanted vestibular schwannoma in athymic nude mice. 61 54
8820351 1996
19
Molecular genetic analysis of the mechanism of tumorigenesis in acoustic neuroma. 61 54
8217082 1993
20
Gamma Knife Treatment of Vestibular Schwannoma Planned With Computed Tomography Cisternography. 61
33748544 2021
21
Clinical evaluation of a real-time inverse planning for Gamma Knife radiosurgery by convex optimization: a prospective comparative trial in a series of vestibular schwannoma patients. 61
33398540 2021
22
Identification of factors associated with tinnitus outcomes following the microsurgical treatment of vestibular schwannoma patients. 61
33439063 2021
23
Predictive Ability of Direct Electrical Stimulation on Facial Nerve Function Following Vestibular Schwannoma Surgery: A Systematic Review and Meta-analysis. 61
33394939 2021
24
Fluorescent Detection of Vestibular Schwannoma Using Intravenous Sodium Fluorescein In Vivo. 61
33492057 2021
25
The Association of Vestibular Schwannoma Volume With Facial Nerve Outcomes After Surgical Resection. 61
33006401 2021
26
Postural Sway Predicts Growth in Untreated Vestibular Schwannoma: A Retrospective Volumetric Study. 61
33443976 2021
27
Vestibular Schwannoma Surgery: Outcome and Complications in Lateral Decubitus Position versus Semi-sitting Position-A Personal Learning Curve in a Series of 544 Cases over 3 Decades. 61
33383200 2021
28
Treatment Analysis and Overall Survival Outcomes of Patients With Bilateral Vestibular Schwannoma. 61
33351555 2021
29
Sporadic vestibular schwannoma: a molecular testing summary. 61
32576656 2021
30
Increased Radiosurgery Toxicity Associated With Treatment of Vestibular Schwannoma in Multiple Sclerosis. 61
33351559 2021
31
The Stanford stereotactic radiosurgery experience on 7000 patients over 2 decades (1999-2018): looking far beyond the scalpel. 61
33799297 2021
32
Cochlear Implantation in Sporadic Vestibular Schwannoma and Other Retrocochlear Pathology: A Case Series. 61
33351558 2021
33
Vibration-induced nystagmus and head impulse test screening for vestibular schwannoma. 61
33583327 2021
34
Cochlear Implant Outcomes in Neurofibromatosis Type 2: Implications for Management. 61
33351557 2021
35
Can an Imaging Marker of Consistency Predict Intraoperative Experience and Clinical Outcomes for Vestibular Schwannomas? A Retrospective Review. 61
33777640 2021
36
Facial nerve length influence on vestibular schwannoma microsurgery outcomes. 61
33737256 2021
37
Malignant vestibular schwannoma with intracerebral metastasis. 61
33686895 2021
38
Vestibular dose correlates with dizziness after radiosurgery for the treatment of vestibular schwannoma. 61
33771181 2021
39
COX2 expression is associated with preoperative tumor volume but not with volumetric tumor growth in vestibular schwannoma. 61
33641674 2021
40
Management and Outcomes of Sporadic Vestibular Schwannoma: A Longitudinal Study Over 12 Years. 61
32710655 2021
41
Vestibular schwannoma: care for soft tissues and subperineural dissection: how I do it. 61
33704585 2021
42
Useful hearing preservation is improved in vestibular schwannoma patients who undergo stereotactic radiosurgery before further hearing deterioration ensues. 61
33733428 2021
43
Intracanalicular Vestibular Schwannoma: A Systematic Review and Meta-analysis of Therapeutics Outcomes. 61
33555742 2021
44
Prediction of Vestibular Schwannoma Enlargement After Radiosurgery Using Tumor Shape and MRI Texture Features. 61
33065598 2021
45
Comparing the impact of upfront radiosurgery versus expectation in vestibular schwannoma (the V-REX study): protocol for a randomised, observer-blinded, 4-year, parallel-group, single-centre, superiority study. 61
33737417 2021
46
Electrode Alternative for Eighth Nerve Monitoring During Vestibular Schwannoma Resection. 61
32692872 2021
47
MiR-205 Inhibits Sporadic Vestibular Schwannoma Cell Proliferation by Targeting Cyclin-Dependent Kinase 14. 61
33217595 2021
48
A case of vestibular schwannoma mimicking burning mouth syndrome. 61
33743774 2021
49
Efficacy of aspirin for sporadic vestibular schwannoma: a meta-analysis. 61
33772351 2021
50
Head movement kinematics are altered during gaze stability exercises in vestibular schwannoma patients. 61
33785796 2021

Variations for Acoustic Neuroma

Expression for Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for Acoustic Neuroma

Pathways related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.97 PCNA MGMT ERCC4 ERCC2 BRIP1 APEX1
2
Show member pathways
12.41 PCNA MGMT ERCC4 ERCC2 APEX1
3 12.32 RDX MIR96 EZR ERBB3
4 12.3 RDX NF2 MSN EZR
5 11.87 TGFB1 RDX MSN EZR ERBB3
6
Show member pathways
11.79 PCNA ERCC4 ERCC2
7 11.76 NF2 NF1 MGMT
8 11.64 TGFB1 AQP4 AQP1 APEX1
9 11.58 RDX PCNA NF2 MSN EZR
10 11.57 PCNA MGMT ERCC4 ERCC2 BRIP1 APEX1
11
Show member pathways
11.5 RDX MSN EZR
12 11.16 RDX MSN EZR
13 11.02 TGFB1 NF1 EZR
14 10.78 TGFB1 RDX MSN EZR ERBB3
15 10.57 ERCC2 BRIP1

GO Terms for Acoustic Neuroma

Cellular components related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 9.65 MSN EZR ERBB3 AQP4 AQP1
2 apical part of cell GO:0045177 9.62 NF2 MSN EZR AQP1
3 cell periphery GO:0071944 9.58 RDX MSN EZR
4 filopodium GO:0030175 9.46 RDX NF2 MSN EZR
5 uropod GO:0001931 9.43 MSN EZR
6 cell tip GO:0051286 9.37 RDX EZR
7 microvillus GO:0005902 9.26 TGFB1 RDX MSN EZR
8 apical plasma membrane GO:0016324 9.1 RDX MSN EZR ERBB3 AQP6 AQP1

Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.03 TGFB1 RDX MSN EZR ERBB3
2 response to drug GO:0042493 9.96 TGFB1 MGMT APEX1 ABCA2
3 cellular response to DNA damage stimulus GO:0006974 9.93 PCNA MGMT ERCC4 ERCC2 BRIP1 APEX1
4 heart development GO:0007507 9.92 TGFB1 PCNA NF1 ERBB3
5 DNA repair GO:0006281 9.88 PCNA MGMT ERCC4 ERCC2 BRIP1 APEX1
6 wound healing GO:0042060 9.83 TGFB1 NF1 ERBB3
7 transcription-coupled nucleotide-excision repair GO:0006283 9.79 PCNA ERCC4 ERCC2
8 cellular response to hydrogen peroxide GO:0070301 9.77 PCNA AQP1 APEX1
9 cellular response to cAMP GO:0071320 9.75 EZR AQP1 APEX1
10 cellular response to UV GO:0034644 9.74 PCNA ERCC4 AQP1
11 telomere maintenance GO:0000723 9.73 PCNA ERCC4 APEX1
12 nucleotide-excision repair GO:0006289 9.69 ERCC4 ERCC2 BRIP1
13 nucleotide-excision repair, DNA incision GO:0033683 9.67 PCNA ERCC4 ERCC2
14 establishment of epithelial cell apical/basal polarity GO:0045198 9.66 MSN EZR
15 negative regulation of cell-cell adhesion GO:0022408 9.65 TGFB1 NF2
16 protein kinase A signaling GO:0010737 9.65 RDX EZR
17 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.65 PCNA ERCC4 ERCC2
18 UV protection GO:0009650 9.64 ERCC4 ERCC2
19 response to cholesterol GO:0070723 9.64 TGFB1 ABCA2
20 lens fiber cell differentiation GO:0070306 9.63 TGFB1 NF2
21 multicellular organismal water homeostasis GO:0050891 9.62 AQP4 AQP1
22 gland morphogenesis GO:0022612 9.61 MSN EZR
23 regulation of cell size GO:0008361 9.61 RDX MSN EZR
24 cellular water homeostasis GO:0009992 9.59 AQP4 AQP1
25 negative regulation of neuroblast proliferation GO:0007406 9.58 TGFB1 NF1
26 central nervous system myelin formation GO:0032289 9.55 ERCC2 ABCA2
27 membrane to membrane docking GO:0022614 9.54 MSN EZR
28 establishment of endothelial barrier GO:0061028 9.54 RDX MSN EZR
29 carbon dioxide transport GO:0015670 9.52 AQP6 AQP1
30 water transport GO:0006833 9.5 AQP6 AQP4 AQP1
31 positive regulation of cellular protein catabolic process GO:1903364 9.43 RDX MSN EZR
32 positive regulation of protein localization to early endosome GO:1902966 9.33 RDX MSN EZR
33 positive regulation of early endosome to late endosome transport GO:2000643 9.13 RDX MSN EZR
34 regulation of organelle assembly GO:1902115 8.8 RDX MSN EZR

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 9.62 PCNA EZR ERCC4 ERCC2
2 protein N-terminus binding GO:0047485 9.61 TGFB1 ERCC4 ERCC2
3 cytoskeletal protein binding GO:0008092 9.46 RDX NF2 MSN EZR
4 channel activity GO:0015267 9.43 AQP6 AQP4 AQP1
5 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0016818 9.4 ERCC2 BRIP1
6 endodeoxyribonuclease activity GO:0004520 9.37 ERCC4 APEX1
7 water channel activity GO:0015250 9.13 AQP6 AQP4 AQP1
8 damaged DNA binding GO:0003684 8.92 PCNA ERCC4 ERCC2 APEX1

Sources for Acoustic Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....