MCID: ACS001
MIFTS: 62

Acoustic Neuroma

Categories: Cancer diseases, Ear diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acoustic Neuroma

MalaCards integrated aliases for Acoustic Neuroma:

Name: Acoustic Neuroma 12 77 54 60 44 15 74
Vestibular Schwannoma 12 54 60 30 15
Cerebellopontine Angle Tumor 54 74
Acoustic Neurilemoma 54 60
Acoustic Neurinoma 54 60
Neurinoma of the Acoustic Nerve 54
Vestibular Neurilemmoma 12
Neuroma, Acoustic 45
Neuroma Acoustic 56
Acoustic Tumor 54

Characteristics:

Orphanet epidemiological data:

60
vestibular schwannoma
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12689
MeSH 45 D009464
NCIt 51 C3276
SNOMED-CT 69 985004
ICD10 via Orphanet 35 D33.3
UMLS via Orphanet 75 C0027859
Orphanet 60 ORPHA252175

Summaries for Acoustic Neuroma

MedlinePlus : 44 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. The tumor usually grows slowly. As it grows, it presses against the hearing and balance nerves. At first, you may have no symptoms or mild symptoms. They can include Loss of hearing on one side Ringing in ears Dizziness and balance problems The tumor can also eventually cause numbness or paralysis of the face. If it grows large enough, it can press against the brain, becoming life-threatening. Acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. Ear exams, hearing tests, and scans can show if you have it. If the tumor stays small, you may only need to have it checked regularly. If you do need treatment, surgery and radiation are options. If the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. NIH: National Institute on Deafness and Communication Disorders

MalaCards based summary : Acoustic Neuroma, also known as vestibular schwannoma, is related to neurilemmomatosis and neuroma, and has symptoms including seizures, tremor and back pain. An important gene associated with Acoustic Neuroma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Transcription-Coupled Nucleotide Excision Repair (TC-NER). The drugs Gentamicins and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 252175Disease definitionVestibular schwannoma is a rare tumor of the posterior fossa originating in the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve that can be benign, small, slow growing and asymptomatic or large, faster growing and aggressive and potentially fatal, presenting with symptoms of hearing and balance impairment, vertigo, ataxia, headache and fifth, sixth or seventh cranial nerve dysfunction and facial numbness.Visit the Orphanet disease page for more resources.

Wikipedia : 77 A vestibular schwannoma (VS) is a benign primary intracranial tumor of the myelin-forming cells of the... more...

Related Diseases for Acoustic Neuroma

Diseases related to Acoustic Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 192)
# Related Disease Score Top Affiliating Genes
1 neurilemmomatosis 32.5 NF1 NF2
2 neuroma 32.5 BICRA NF2 TGFB1
3 facial paralysis 31.1 NF2 TGFB1
4 spinal meningioma 30.8 NF1 NF2
5 meningioma, familial 30.7 NF1 NF2 PCNA
6 neurofibrosarcoma 30.5 NF1 NF2
7 neurofibromatosis, type iv, of riccardi 12.3
8 neurofibromatosis, type ii 11.5
9 neurofibromatosis, type i 11.5
10 schwannomatosis 1 11.2
11 schwannomatosis 2 11.2
12 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
13 headache 10.5
14 cerebrospinal fluid leak 10.4
15 secretory meningioma 10.4
16 hydrocephalus 10.3
17 sensorineural hearing loss 10.3
18 benign meningioma 10.3 NF2 PCNA
19 meningitis 10.3
20 glioma 10.3
21 heritable pulmonary arterial hypertension 10.3 AQP1 TGFB1
22 malignant ependymoma 10.3 ERCC5 NF2
23 otosclerosis 10.3
24 cockayne syndrome a 10.3 ERCC4 ERCC5
25 neurofibromatosis, familial spinal 10.2 NF1 NF2
26 otosclerosis 1 10.2
27 arteriovenous malformation 10.2
28 glioblastoma 10.2
29 plexiform schwannoma 10.2 NF1 NF2
30 immature cataract 10.2 NF1 NF2
31 cerebro-oculo-facio-skeletal syndrome 10.2 ERCC4 ERCC5
32 plexiform neurofibroma 10.2 NF1 NF2
33 atypical neurofibroma 10.2 NF1 NF2
34 trigeminal nerve neoplasm 10.2 NF1 NF2
35 neurilemmoma of the fifth cranial nerve 10.2 NF1 NF2
36 amyloid tumor 10.2 NF1 NF2
37 sarcoma 10.2
38 congenital hydrocephalus 10.2
39 lattice corneal dystrophy 10.2 TGFB1 TGIF1
40 meniere disease 10.2
41 myoclonus and ataxia 10.2
42 trigeminal neuralgia 10.2
43 glioblastoma multiforme 10.2
44 depression 10.2
45 spinal canal and spinal cord meningioma 10.1 NF1 NF2
46 camurati-engelmann disease 10.1 TGFB1 TGIF1
47 astrocytoma 10.1
48 malignant peripheral nerve sheath tumor 10.1
49 neuropathy 10.1
50 ependymoma 10.1

Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to Acoustic Neuroma

Symptoms & Phenotypes for Acoustic Neuroma

UMLS symptoms related to Acoustic Neuroma:


seizures, tremor, back pain, pain, headache, tinnitus, syncope, snoring, chronic pain, sciatica, sore throat, coughing, vertigo/dizziness, equilibration disorder, sleeplessness

GenomeRNAi Phenotypes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.78 AQP1 ERCC4 ERCC5 PCNA TGFB1 XRCC1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.78 AQP1 ERCC4 ERCC5 PCNA TGFB1 XRCC1
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.63 BRIP1 ERCC4 ERCC5 PCNA XRCC1 XRCC3
4 Synthetic lethal with cisplatin GR00101-A-1 9.13 BRIP1 NF2 XRCC3

MGI Mouse Phenotypes related to Acoustic Neuroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.1 ABCA2 AQP1 ERCC4 ERCC5 NF1 NF2
2 homeostasis/metabolism MP:0005376 10.02 ABCA2 AQP1 BRIP1 ERCC5 NF1 NF2
3 mortality/aging MP:0010768 10 ABCA2 AQP1 ERCC4 ERCC5 NF1 NF2
4 liver/biliary system MP:0005370 9.8 BRIP1 ERCC4 ERCC5 NF1 NF2 TGFB1
5 nervous system MP:0003631 9.56 ABCA2 AQP1 BRIP1 NF1 NF2 TGFB1
6 neoplasm MP:0002006 9.55 BRIP1 NF1 NF2 TGFB1 XRCC1
7 reproductive system MP:0005389 9.17 ABCA2 AQP1 BRIP1 NF2 PCNA TGFB1

Drugs & Therapeutics for Acoustic Neuroma

Drugs for Acoustic Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Gentamicins Phase 4,Not Applicable
2 Anti-Infective Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
3 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
4
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
5
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
6
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
7
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
8
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
9 Peripheral Nervous System Agents Phase 3,Phase 2
10 Neuroprotective Agents Phase 3
11 Antineoplastic Agents, Hormonal Phase 3,Not Applicable
12 glucocorticoids Phase 3
13 Autonomic Agents Phase 3
14 Prednisolone acetate Phase 3
15 Hormones Phase 3
16 Anti-Inflammatory Agents Phase 3,Phase 2
17 Methylprednisolone Acetate Phase 3
18 Protective Agents Phase 3
19 Hormone Antagonists Phase 3
20 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
21 Gastrointestinal Agents Phase 3,Not Applicable
22 Antiemetics Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 6442177 70789204
25
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
26
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 46835353 6436030 5284616
27
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
28
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
29
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 388082-78-8, 231277-92-2 208908 9941095
30
Lactitol Investigational Phase 2 585-86-4, 585-88-6 493591
31 Antibodies, Monoclonal Phase 2
32 Immunoglobulins Phase 2
33 Antibodies Phase 2
34 Immunologic Factors Phase 2,Early Phase 1
35 Angiogenesis Inhibitors Phase 2,Phase 1
36 Antineoplastic Agents, Immunological Phase 2,Phase 1
37 Angiogenesis Modulating Agents Phase 2,Phase 1
38 Antifungal Agents Phase 2,Early Phase 1
39 Immunosuppressive Agents Phase 2,Early Phase 1
40 Antibiotics, Antitubercular Phase 2,Early Phase 1
41 Endostatins Phase 2 71581480
42 Protein Kinase Inhibitors Phase 2,Early Phase 1
43 Fibrinolytic Agents Phase 2
44 Analgesics, Non-Narcotic Phase 2
45 Antirheumatic Agents Phase 2
46 Antipyretics Phase 2
47 Platelet Aggregation Inhibitors Phase 2
48 Cyclooxygenase Inhibitors Phase 2
49 Anti-Inflammatory Agents, Non-Steroidal Phase 2
50 Analgesics Phase 2

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Unknown status NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
5 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
6 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
7 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
8 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2 RAD001
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2 Endostatin
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
11 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2 Everolimus (RAD001) , Afinitor®
12 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
13 RGD PET/MRI in Sporadic Vestibular Schwannoma Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Study of Aspirin in Patients With Vestibular Schwannoma Recruiting NCT03079999 Phase 2 Aspirin;Placebo
16 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
17 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2 Bevacizumab
18 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
19 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
20 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Active, not recruiting NCT02831257 Phase 2 AZD2014
21 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
22 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
23 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
24 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
25 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
26 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Unknown status NCT02275325 Not Applicable
27 Response Prediction After GKS in Patients With Vestibular Schwannoma Using DCE MR Imaging Unknown status NCT03097822
28 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231 Not Applicable
29 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
30 Role of Psychiatric Profile in Prehabituated Patients After Vestibular Schwannoma Surgery Completed NCT03638310 Not Applicable
31 Vestibular Evaluation After Vestibular Schwannoma Treatment Completed NCT03670589
32 Concentration and Activity of Lapatinib in Vestibular Schwannomas Completed NCT00863122 Early Phase 1 lapatinib
33 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896 Not Applicable gentamicin
34 WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Completed NCT03210285
35 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099 Not Applicable
36 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
37 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Completed NCT02811718 Not Applicable
38 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
39 A Family Study of Adults With Glioma Completed NCT00339352
40 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
41 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560 Not Applicable
42 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Recruiting NCT02948790 Not Applicable
43 Vestibular Outcomes in Vestibular Schwannoma Recruiting NCT03346889
44 Secondary Endolymphatic Hydrops and Vestibular Schwannomas on 3 Tesla MRI Recruiting NCT03593577
45 Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results Recruiting NCT03745560
46 CI Following VS Removal or Labyrinthectomy Recruiting NCT03795675 Not Applicable
47 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726 Not Applicable
48 Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study Recruiting NCT03745534
49 Consequence of Unilateral Vestibular Loss on Visual Abilities Recruiting NCT03581331 Not Applicable
50 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Recruiting NCT03520829

Search NIH Clinical Center for Acoustic Neuroma

Cochrane evidence based reviews: neuroma, acoustic

Genetic Tests for Acoustic Neuroma

Genetic tests related to Acoustic Neuroma:

# Genetic test Affiliating Genes
1 Vestibular Schwannoma 30

Anatomical Context for Acoustic Neuroma

MalaCards organs/tissues related to Acoustic Neuroma:

42
Brain, Testes, Bone, Pituitary, Lung, Neutrophil, Temporal Lobe

Publications for Acoustic Neuroma

Articles related to Acoustic Neuroma:

(show top 50) (show all 2418)
# Title Authors Year
1
Spontaneous Shrinkage of Cystic Acoustic Neuroma: A Case Report. ( 30685372 )
2019
2
Influence of Selection Bias in Survey Studies Derived From a Patient-Focused Organization: A Comparison of Response Data From a Single Tertiary Care Center and the Acoustic Neuroma Association. ( 30807524 )
2019
3
Influence of Selection Bias in Survey Studies Derived From a Patient-Focused Organization: A Comparison of Response Data From a Single Tertiary Care Center and the Acoustic Neuroma Association. ( 30870367 )
2019
4
Coexistent Vestibular Schwannoma and Creutzfeldt-Jakob Disease: Recognition and Infection Control. ( 30742601 )
2019
5
Sensorineural hearing loss in patients with vestibular schwannoma correlates with the presence of utricular hydrops as diagnosed on heavily T2-weighted MRI. ( 30773403 )
2019
6
Improvement or Recovery From Sudden Sensorineural Hearing Loss With Steroid Therapy Does Not Preclude the Need for MRI to Rule Out Vestibular Schwannoma. ( 30807520 )
2019
7
Acute sensorineural hearing loss in patients with vestibular schwannoma early after cyberknife radiosurgery. ( 30769220 )
2019
8
Trigeminal neuralgia in vestibular schwannoma: Atypical presentation and neuroanatomical correlations. ( 30905383 )
2019
9
Intraoperative Monitoring of the Cochlear Nerve during Neurofibromatosis Type-2 Vestibular Schwannoma Surgery and Description of a "Test Intracochlear Electrode". ( 30723658 )
2019
10
Tumor-to-Tumor Metastasis From a Breast Carcinoma to a Vestibular Schwannoma. ( 30531647 )
2019
11
An international comparison of diagnostic and management strategies for vestibular schwannoma. ( 30421174 )
2019
12
Perioperative Recording of Cochlear Implant Evoked Brain Stem Responses After Removal of the Intralabyrinthine Portion of a Vestibular Schwannoma in a Patient with NF2. ( 30531638 )
2019
13
Brazilein induces apoptosis and G1/G0 phase cell cycle arrest by up-regulation of miR-133a in human vestibular schwannoma cells. ( 30610843 )
2019
14
Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study. ( 30614502 )
2019
15
A cerebellopontine angle mouse model for the investigation of tumor biology, hearing, and neurological function in NF2-related vestibular schwannoma. ( 30617350 )
2019
16
Tumor growth rate: A new prognostic indicator of hearing preservation in vestibular schwannoma surgery. ( 30623429 )
2019
17
Malignant Transformation of Vestibular Schwannoma after Stereotactic Radiosurgery. ( 30639496 )
2019
18
Ocular Tilt Reaction in Compensated Vestibular Schwannoma. ( 30640312 )
2019
19
Cochlear FLAIR Signal Changes in Hearing Preservation Vestibular Schwannoma Surgery. ( 30664035 )
2019
20
Prevalence of sporadic vestibular schwannoma: Reconciling temporal bone, radiologic, and population-based studies. ( 30688755 )
2019
21
Comparison of balance outcomes according to treatment modality of vestibular schwannoma. ( 30693520 )
2019
22
Management of jugular bulb injury during drilling of the internal auditory canal (ICA) for vestibular schwannoma surgery. ( 30704809 )
2019
23
Impact of Aspirin and Other NSAID Use on Volumetric and Linear Growth in Vestibular Schwannoma. ( 30717626 )
2019
24
Chances of Improvement in Cases of Vestibular Schwannoma Presenting with Facial Nerve Weakness: Presentation of Two Cases and Literature Review. ( 30733899 )
2019
25
Variation in Coding Practices for Vestibular Schwannoma Surgery. ( 30733907 )
2019
26
Variation in Coding Practices for Vestibular Schwannoma Surgery. ( 30733908 )
2019
27
Changes in tinnitus after vestibular schwannoma surgery. ( 30742012 )
2019
28
Medical Malpractice of Vestibular Schwannoma: A 40-Year Review of the United States Legal Databases. ( 30742599 )
2019
29
Short-Term Surgical Outcome for Vestibular Schwannoma in Sweden: A Nation-Wide Registry Study. ( 30761075 )
2019
30
LINAC radiosurgery treatment for vestibular schwannoma. ( 30770322 )
2019
31
Audiologic prognostic factors for hearing preservation following vestibular schwannoma surgery. ( 30784239 )
2019
32
Optic nerve sheath fenestration in patients with visual failure associated with vestibular schwannoma. ( 30829548 )
2019
33
The shrinking vestibular schwannoma. ( 30829550 )
2019
34
Vestibular schwannoma extending into the tympanic cavity and jugular fossa by invasion of the petrous bone. ( 30856348 )
2019
35
Recent Trends in Vestibular Schwannoma Management: An 11-Year Analysis of the National Cancer Database. ( 30857474 )
2019
36
Sketching the facial nerve on vestibular schwannoma. ( 30860097 )
2019
37
Impact of Gkrs on Vestibular Schwannoma with Serviceable Hearing: A Single Center Indian Study. ( 30862586 )
2019
38
In search of the most cost-effective monitoring strategy for vestibular schwannoma: a decision analytical modelling study. ( 30864276 )
2019
39
Video Head Impulse Test in Vestibular Schwannoma: Relevance of Size and Cystic Component on Vestibular Impairment. ( 30870368 )
2019
40
Cochlear Implantation in Patients With Single-sided Deafness After the Translabyrinthine Resection of the Vestibular Schwannoma-Presented at the Annual Meeting of ADANO 2016 in Berlin. ( 30870381 )
2019
41
Risk Recall of Complications Associated with Vestibular Schwannoma Treatment. ( 30885097 )
2019
42
A-train clusters and the intermedius nerve in vestibular schwannoma patients. ( 30901633 )
2019
43
Associations of Video Head Impulse Test and Caloric Testing among Patients with Vestibular Schwannoma. ( 30909803 )
2019
44
Risk of posterior semicircular canal trauma when using a retrosigmoid approach for acoustic neuroma surgery and role of endoscopy: An imaging study. ( 29493720 )
2018
45
Acoustic Neuroma Treated with Stereotactic Radiosurgery: Follow-up of 335 Patients. ( 29715569 )
2018
46
Patient Decision Making in Vestibular Schwannoma: A Survey of the Acoustic Neuroma Association. ( 29436268 )
2018
47
Increased sensibility to acute acoustic and blast trauma among patients with acoustic neuroma. ( 29184217 )
2018
48
Cochlea-sparing acoustic neuroma treatment with 4I8 radiation therapy. ( 29904732 )
2018
49
Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery. ( 29889284 )
2018
50
Acoustic neuroma quality of life: are we missing the point? ( 29948270 )
2018

Variations for Acoustic Neuroma

Expression for Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for Acoustic Neuroma

Pathways related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.44 BRIP1 ERCC4 ERCC5 PCNA XRCC1 XRCC3
2
Show member pathways
12.4 ERCC4 ERCC5 PCNA XRCC1
3
Show member pathways
12.23 ERCC4 ERCC5 PCNA XRCC1
4 11.93 BRIP1 ERCC4 PCNA XRCC1
5
Show member pathways
11.5 ERCC4 ERCC5 PCNA
6
Show member pathways
11.22 BRIP1 ERCC4 PCNA XRCC3
7 10.92 NF1 TGFB1

GO Terms for Acoustic Neuroma

Cellular components related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 AQP1 BICRA BRIP1 ERCC4 ERCC5 NF1
2 replication fork GO:0005657 9.32 PCNA XRCC3
3 nucleotide-excision repair complex GO:0000109 9.26 ERCC4 ERCC5
4 ERCC4-ERCC1 complex GO:0070522 9.16 ERCC4 XRCC1
5 nuclear chromosome, telomeric region GO:0000784 8.92 ERCC4 PCNA XRCC1 XRCC3

Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.89 BRIP1 NF1 NF2 TGFB1
2 regulation of cell proliferation GO:0042127 9.8 NF1 NF2 TGFB1
3 response to hypoxia GO:0001666 9.79 NF1 TGFB1 XRCC1
4 response to organic substance GO:0010033 9.72 TGFB1 XRCC1 XRCC3
5 double-strand break repair via homologous recombination GO:0000724 9.7 ERCC4 XRCC1 XRCC3
6 cellular response to UV GO:0034644 9.67 AQP1 ERCC4 PCNA
7 response to drug GO:0042493 9.65 ABCA2 AQP1 TGFB1 TGIF1 XRCC1
8 liver regeneration GO:0097421 9.64 PCNA TGFB1
9 cellular response to dexamethasone stimulus GO:0071549 9.63 AQP1 TGFB1
10 nucleotide-excision repair GO:0006289 9.63 BRIP1 ERCC4 ERCC5
11 cellular response to DNA damage stimulus GO:0006974 9.63 BRIP1 ERCC4 ERCC5 PCNA XRCC1 XRCC3
12 negative regulation of MAPK cascade GO:0043409 9.62 NF1 NF2
13 cell-cell junction organization GO:0045216 9.61 NF2 TGFB1
14 nucleotide-excision repair, DNA gap filling GO:0006297 9.61 PCNA XRCC1
15 negative regulation of cell-matrix adhesion GO:0001953 9.6 NF1 NF2
16 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.58 ERCC4 ERCC5
17 negative regulation of cell-cell adhesion GO:0022408 9.58 NF2 TGFB1
18 lens fiber cell differentiation GO:0070306 9.57 NF2 TGFB1
19 UV protection GO:0009650 9.56 ERCC4 ERCC5
20 response to cholesterol GO:0070723 9.54 ABCA2 TGFB1
21 nucleotide-excision repair, DNA incision GO:0033683 9.54 ERCC4 ERCC5 PCNA
22 negative regulation of neuroblast proliferation GO:0007406 9.51 NF1 TGFB1
23 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.5 ERCC4 ERCC5 PCNA
24 nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006295 9.48 ERCC4 ERCC5
25 negative regulation of protection from non-homologous end joining at telomere GO:1905765 9.43 ERCC4 XRCC1
26 telomeric DNA-containing double minutes formation GO:0061819 9.4 ERCC4 XRCC1
27 transcription-coupled nucleotide-excision repair GO:0006283 9.26 ERCC4 ERCC5 PCNA XRCC1
28 DNA repair GO:0006281 9.1 BRIP1 ERCC4 ERCC5 PCNA XRCC1 XRCC3

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.33 ERCC4 ERCC5 TGFB1
2 endodeoxyribonuclease activity GO:0004520 9.26 ERCC4 ERCC5
3 damaged DNA binding GO:0003684 9.13 ERCC4 PCNA XRCC1
4 3' overhang single-stranded DNA endodeoxyribonuclease activity GO:1990599 8.62 ERCC4 XRCC1
5 protein binding GO:0005515 10.1 AQP1 BICRA BRIP1 ERCC4 ERCC5 NF1

Sources for Acoustic Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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