MCID: ACS001
MIFTS: 61

Acoustic Neuroma

Categories: Cancer diseases, Ear diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acoustic Neuroma

MalaCards integrated aliases for Acoustic Neuroma:

Name: Acoustic Neuroma 12 77 54 60 44 15 74
Vestibular Schwannoma 12 54 60 15
Cerebellopontine Angle Tumor 54 74
Acoustic Neurilemoma 54 60
Acoustic Neurinoma 54 60
Neurinoma of the Acoustic Nerve 54
Vestibular Neurilemmoma 12
Neuroma, Acoustic 45
Neuroma Acoustic 56
Acoustic Tumor 54

Characteristics:

Orphanet epidemiological data:

60
vestibular schwannoma
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12689
MeSH 45 D009464
NCIt 51 C3276
SNOMED-CT 69 985004
ICD10 via Orphanet 35 D33.3
UMLS via Orphanet 75 C0027859
Orphanet 60 ORPHA252175

Summaries for Acoustic Neuroma

MedlinePlus : 44 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. The tumor usually grows slowly. As it grows, it presses against the hearing and balance nerves. At first, you may have no symptoms or mild symptoms. They can include Loss of hearing on one side Ringing in ears Dizziness and balance problems The tumor can also eventually cause numbness or paralysis of the face. If it grows large enough, it can press against the brain, becoming life-threatening. Acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. Ear exams, hearing tests, and scans can show if you have it. If the tumor stays small, you may only need to have it checked regularly. If you do need treatment, surgery and radiation are options. If the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. NIH: National Institute on Deafness and Communication Disorders

MalaCards based summary : Acoustic Neuroma, also known as vestibular schwannoma, is related to neurilemmomatosis and neuroma, and has symptoms including seizures, tremor and back pain. An important gene associated with Acoustic Neuroma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Transcription-Coupled Nucleotide Excision Repair (TC-NER) and DNA Double-Strand Break Repair. The drugs Anti-Infective Agents and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Synthetic lethal with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

NIH Rare Diseases : 54 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 252175Disease definitionVestibular schwannoma is a rare tumor of the posterior fossa originating in the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve that can be benign, small, slow growing and asymptomatic or large, faster growing and aggressive and potentially fatal, presenting with symptoms of hearing and balance impairment, vertigo, ataxia, headache and fifth, sixth or seventh cranial nerve dysfunction and facial numbness.Visit the Orphanet disease page for more resources.

Wikipedia : 77 A vestibular schwannoma (VS) is a benign primary intracranial tumor of the myelin-forming cells of the... more...

Related Diseases for Acoustic Neuroma

Diseases related to Acoustic Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 198)
# Related Disease Score Top Affiliating Genes
1 neurilemmomatosis 32.6 NF1 NF2
2 neuroma 32.5 BICRA NF2 TGFB1
3 facial paralysis 31.3 NF2 TGFB1
4 spinal meningioma 30.5 NF1 NF2
5 neurofibrosarcoma 30.5 NF1 NF2
6 meningioma, familial 30.4 NF1 NF2 PCNA
7 neurofibromatosis, type iv, of riccardi 12.3
8 neurofibromatosis, type ii 11.5
9 neurofibromatosis, type i 11.5
10 schwannomatosis 1 11.3
11 schwannomatosis 2 11.3
12 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.7
13 headache 10.5
14 cerebrospinal fluid leak 10.4
15 neurilemmoma 10.4
16 meniere disease 10.3
17 hydrocephalus 10.3
18 sensorineural hearing loss 10.3
19 meningitis 10.3
20 glioma 10.3
21 benign meningioma 10.3 NF2 PCNA
22 heritable pulmonary arterial hypertension 10.3 AQP1 TGFB1
23 malignant ependymoma 10.3 ERCC5 NF2
24 otosclerosis 10.3
25 cockayne syndrome a 10.3 ERCC4 ERCC5
26 neurofibromatosis, familial spinal 10.2 NF1 NF2
27 arteriovenous malformation 10.2
28 secretory meningioma 10.2
29 glioblastoma 10.2
30 plexiform schwannoma 10.2 NF1 NF2
31 immature cataract 10.2 NF1 NF2
32 cerebro-oculo-facio-skeletal syndrome 10.2 ERCC4 ERCC5
33 plexiform neurofibroma 10.2 NF1 NF2
34 atypical neurofibroma 10.2 NF1 NF2
35 trigeminal nerve neoplasm 10.2 NF1 NF2
36 neurilemmoma of the fifth cranial nerve 10.2 NF1 NF2
37 sarcoma 10.2
38 amyloid tumor 10.2 NF1 NF2
39 pediatric ependymoma 10.2 APEX1 ERCC5
40 lattice corneal dystrophy 10.2 TGFB1 TGIF1
41 myoclonus and ataxia 10.2
42 trigeminal neuralgia 10.2
43 glioblastoma multiforme 10.2
44 depression 10.2
45 spinal canal and spinal cord meningioma 10.1 NF1 NF2
46 astrocytoma 10.1
47 benign ependymoma 10.1
48 malignant peripheral nerve sheath tumor 10.1
49 neuropathy 10.1
50 ependymoma 10.1

Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to Acoustic Neuroma

Symptoms & Phenotypes for Acoustic Neuroma

UMLS symptoms related to Acoustic Neuroma:


seizures, tremor, back pain, pain, headache, tinnitus, syncope, snoring, chronic pain, sciatica, sore throat, coughing, vertigo/dizziness, equilibration disorder, sleeplessness

GenomeRNAi Phenotypes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.77 AQP1 ERCC4 ERCC5 PCNA TGFB1 XRCC1
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.77 AQP1 ERCC4 ERCC5 PCNA TGFB1 XRCC1
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.63 APEX1 ERCC4 ERCC5 PCNA XRCC1 XRCC3
4 Synthetic lethal with cisplatin GR00101-A-1 8.96 NF2 XRCC3

MGI Mouse Phenotypes related to Acoustic Neuroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.14 ABCA2 APEX1 AQP1 ERCC4 ERCC5 NF1
2 homeostasis/metabolism MP:0005376 10.02 ABCA2 APEX1 AQP1 ERCC5 NF1 NF2
3 mortality/aging MP:0010768 9.93 ABCA2 APEX1 AQP1 ERCC4 ERCC5 NF1
4 immune system MP:0005387 9.92 APEX1 ERCC5 NF1 NF2 PCNA TGFB1
5 embryo MP:0005380 9.91 APEX1 NF1 NF2 TGFB1 TGIF1 XRCC1
6 liver/biliary system MP:0005370 9.73 APEX1 ERCC4 ERCC5 NF1 NF2 TGFB1
7 neoplasm MP:0002006 9.35 APEX1 NF1 NF2 TGFB1 XRCC1
8 reproductive system MP:0005389 9.17 ABCA2 APEX1 AQP1 NF2 PCNA TGFB1

Drugs & Therapeutics for Acoustic Neuroma

Drugs for Acoustic Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 68)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
2 Gentamicins Phase 4,Not Applicable
3 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
4
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
8
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
9 Antineoplastic Agents, Hormonal Phase 3,Not Applicable
10 glucocorticoids Phase 3
11 Antiemetics Phase 3
12 Hormone Antagonists Phase 3
13 Peripheral Nervous System Agents Phase 3,Phase 2
14 Gastrointestinal Agents Phase 3,Not Applicable
15 Hormones Phase 3
16 Methylprednisolone Acetate Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
18 Anti-Inflammatory Agents Phase 3,Phase 2
19 Protective Agents Phase 3
20 Neuroprotective Agents Phase 3
21 Autonomic Agents Phase 3
22 Prednisolone acetate Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 46835353 5284616 6436030
25
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
26
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 70789204 6442177
27
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
28
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
29
Histamine Approved, Investigational Phase 2 51-45-6 774
30
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
31
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
32
Lactitol Investigational Phase 2 585-88-6, 585-86-4 493591
33 Antibodies, Monoclonal Phase 2
34 Antineoplastic Agents, Immunological Phase 2,Phase 1
35 Antibodies Phase 2
36 Immunologic Factors Phase 2,Early Phase 1
37 Angiogenesis Inhibitors Phase 2,Phase 1
38 Immunoglobulins Phase 2
39 Angiogenesis Modulating Agents Phase 2,Phase 1
40 Immunosuppressive Agents Phase 2,Early Phase 1
41 Antibiotics, Antitubercular Phase 2,Early Phase 1
42 Antifungal Agents Phase 2,Early Phase 1
43 Endostatins Phase 2 71581480
44 Protein Kinase Inhibitors Phase 2,Early Phase 1
45 Analgesics Phase 2
46 Anti-Inflammatory Agents, Non-Steroidal Phase 2
47 Analgesics, Non-Narcotic Phase 2
48 Antipyretics Phase 2
49 Fibrinolytic Agents Phase 2
50 Cyclooxygenase Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 64)
# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Unknown status NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
5 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
6 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
7 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
8 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2 RAD001
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2 Endostatin
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
11 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2 Everolimus (RAD001) , Afinitor®
12 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
13 RGD PET/MRI in Sporadic Vestibular Schwannoma Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Study of Aspirin in Patients With Vestibular Schwannoma Recruiting NCT03079999 Phase 2 Aspirin;Placebo
16 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
17 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2 Bevacizumab
18 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
19 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
20 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Active, not recruiting NCT02831257 Phase 2 AZD2014
21 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
22 AM-125 in the Treatment of Acute Peripheral Vertigo Following Vestibular Schwannoma Resection Not yet recruiting NCT03908567 Phase 2 Intranasal Drug;Oral Tablet
23 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
24 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
25 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
26 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
27 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Unknown status NCT02275325 Not Applicable
28 Response Prediction After GKS in Patients With Vestibular Schwannoma Using DCE MR Imaging Unknown status NCT03097822
29 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231 Not Applicable
30 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
31 Role of Psychiatric Profile in Prehabituated Patients After Vestibular Schwannoma Surgery Completed NCT03638310 Not Applicable
32 Vestibular Evaluation After Vestibular Schwannoma Treatment Completed NCT03670589
33 Concentration and Activity of Lapatinib in Vestibular Schwannomas Completed NCT00863122 Early Phase 1 lapatinib
34 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896 Not Applicable gentamicin
35 WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Completed NCT03210285
36 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099 Not Applicable
37 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
38 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Completed NCT02811718 Not Applicable
39 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
40 A Family Study of Adults With Glioma Completed NCT00339352
41 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
42 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560 Not Applicable
43 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Recruiting NCT02948790 Not Applicable
44 Vestibular Outcomes in Vestibular Schwannoma Recruiting NCT03346889
45 Secondary Endolymphatic Hydrops and Vestibular Schwannomas on 3 Tesla MRI Recruiting NCT03593577
46 Simultaneous Cochlear Implantation During Translabyrinthine Resection of Vestibular Schwannoma Recruiting NCT03958006 Not Applicable
47 Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results Recruiting NCT03745560
48 CI Following VS Removal or Labyrinthectomy Recruiting NCT03795675 Not Applicable
49 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726 Not Applicable
50 Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study Recruiting NCT03745534

Search NIH Clinical Center for Acoustic Neuroma

Cochrane evidence based reviews: neuroma, acoustic

Genetic Tests for Acoustic Neuroma

Anatomical Context for Acoustic Neuroma

MalaCards organs/tissues related to Acoustic Neuroma:

42
Brain, Testes, Bone, Pituitary, Lung, Spinal Cord, Temporal Lobe

Publications for Acoustic Neuroma

Articles related to Acoustic Neuroma:

(show top 50) (show all 2527)
# Title Authors Year
1
Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery. ( 29889284 )
2019
2
Acoustic neuroma quality of life: are we missing the point? ( 29948270 )
2019
3
Topical insulin in neurotrophic keratopathy after resection of acoustic neuroma. ( 30025986 )
2019
4
Primary Glioblastoma of Cerebellopontine Angle in Adult Mimicking Acoustic Neuroma. ( 30347301 )
2019
5
Long-Term Tumor Control Rates Following Gamma Knife Radiosurgery for Acoustic Neuroma. ( 30447465 )
2019
6
Hearing preservation in small acoustic neuroma: observation or active therapy? Literature review and institutional experience. ( 30535851 )
2019
7
Spontaneous Shrinkage of Cystic Acoustic Neuroma: A Case Report. ( 30685372 )
2019
8
Influence of Selection Bias in Survey Studies Derived From a Patient-Focused Organization: A Comparison of Response Data From a Single Tertiary Care Center and the Acoustic Neuroma Association. ( 30807524 )
2019
9
Influence of Selection Bias in Survey Studies Derived From a Patient-Focused Organization: A Comparison of Response Data From a Single Tertiary Care Center and the Acoustic Neuroma Association. ( 30870367 )
2019
10
Hand-Held Thulium Laser Fiber And Ultrasonic Aspirator For Opening The Internal Auditory Canal During Acoustic Neuroma Microneurosurgery: Operative Technique. ( 30928583 )
2019
11
Noise exposure as a risk factor for acoustic neuroma: a systematic review and meta-analysis. ( 31012775 )
2019
12
Validation of self-reported occupational noise exposure in participants of a French case-control study on acoustic neuroma. ( 31028471 )
2019
13
Is endoscopic inspection necessary to detect residual disease in acoustic neuroma surgery? ( 31028535 )
2019
14
An investigation of life quality of patients after two different acoustic neuroma resections. ( 31050576 )
2019
15
De novo cavernous malformation arising in the wall of vestibular schwannoma following stereotactic radiosurgery: case report and review of the literature. ( 30430258 )
2019
16
Coexistent Vestibular Schwannoma and Creutzfeldt-Jakob Disease: Recognition and Infection Control. ( 30742601 )
2019
17
Improvement or Recovery From Sudden Sensorineural Hearing Loss With Steroid Therapy Does Not Preclude the Need for MRI to Rule Out Vestibular Schwannoma. ( 30807520 )
2019
18
Improvement or Recovery From Sudden Sensorineural Hearing Loss With Steroid Therapy Does Not Preclude the Need for MRI to Rule Out Vestibular Schwannoma. ( 31083098 )
2019
19
Acute sensorineural hearing loss in patients with vestibular schwannoma early after cyberknife radiosurgery. ( 30769220 )
2019
20
Sensorineural hearing loss in patients with vestibular schwannoma correlates with the presence of utricular hydrops as diagnosed on heavily T2-weighted MRI. ( 30773403 )
2019
21
Contralateral sensorineural hearing loss after vestibular schwannoma surgery. ( 29929725 )
2019
22
The prevalence of vestibular schwannoma among patients treated as sudden sensorineural hearing loss. ( 30042019 )
2019
23
[18F]fluorothymidine and [18F]fluorodeoxyglucose PET Imaging Demonstrates Uptake and Differentiates Growth in Neurofibromatosis 2 Related Vestibular Schwannoma. ( 31033921 )
2019
24
Surgical management of collision-tumors between vestibular schwannoma and meningioma in the cerebellopontine angle in patients with neurofibromatosis type 2. ( 31044279 )
2019
25
Intraoperative Monitoring of the Cochlear Nerve during Neurofibromatosis Type-2 Vestibular Schwannoma Surgery and Description of a "Test Intracochlear Electrode". ( 30723658 )
2019
26
Tumor-to-Tumor Metastasis From a Breast Carcinoma to a Vestibular Schwannoma. ( 30531647 )
2019
27
An international comparison of diagnostic and management strategies for vestibular schwannoma. ( 30421174 )
2019
28
Changing trends in management of vestibular schwannoma: A National Cancer Database study. ( 30450631 )
2019
29
Treatment of small and medium-sized vestibular schwannoma-a need for better evidence. ( 30467734 )
2019
30
Sudden neurological deterioration due to repeated intratumoral hemorrhage in a patient with a vestibular schwannoma. ( 30381158 )
2019
31
Evaluation of Vertical Semicircular Canal Function in Patients With Vestibular Schwannoma. ( 30360640 )
2019
32
Impact of Motor-Evoked Potential Monitoring on Facial Nerve Outcomes after Vestibular Schwannoma Resection. ( 30343584 )
2019
33
Familial unilateral vestibular schwannoma is rarely caused by inherited variants in the NF2 gene. ( 30325044 )
2019
34
Challenging Anterior Inferior Cerebellar Artery in Retrosigmoid Vestibular Schwannoma Removal. ( 30261396 )
2019
35
Relationship of a "Fundal Fluid Cap" and Vestibular Schwannoma Volume: Analysis of Preoperative Radiographic Findings and Outcomes. ( 30239432 )
2019
36
Acute Presentation of Vestibular Schwannoma Secondary to Intratumoral Hemorrhage: A Case Report and Literature Review. ( 31103763 )
2019
37
Vestibular schwannoma resection in a consecutive series of 502 cases via the retrosigmoid approach: technical aspects, complications and functional outcome. ( 31100515 )
2019
38
Non-Vestibular Schwannoma Radiosurgery. ( 31096238 )
2019
39
Severity of Tinnitus Distress Negatively Impacts Quality of Life in Patients With Vestibular Schwannoma and Mimics Primary Tinnitus. ( 31068888 )
2019
40
A critical comparison between the semisitting and the supine positioning in vestibular schwannoma surgery: subgroup analysis of a randomized, multicenter trial. ( 31051465 )
2019
41
De Novo Vestibular Schwannoma: A Report of Three Cases. ( 31016100 )
2019
42
Prognostic factors of facial nerve function after vestibular schwannoma removal via translabyrinthine approach. ( 30987492 )
2019
43
Ki-67 index as a predictor of vestibular schwannoma regrowth or recurrence. ( 30983565 )
2019
44
Is There a Need for a 6-Month Postradiosurgery Magnetic Resonance Imaging in the Treatment of Vestibular Schwannoma? ( 30980077 )
2019
45
The changing landscape of vestibular schwannoma diagnosis and management: A cross-sectional study. ( 30953401 )
2019
46
Gene expression profiles between cystic and solid vestibular schwannoma indicate susceptible molecules and pathways in the cystic formation of vestibular schwannoma. ( 30953268 )
2019
47
Facial Nerve Paralysis Occurring 4 Days following Stereotactic Radiosurgery for a Vestibular Schwannoma. ( 30937049 )
2019
48
Translabyrinthine Excision of Vestibular Schwannoma with Concurrent Cochlear Implantation: Systematic Review. ( 30931227 )
2019
49
Systematic Review of Hearing Preservation in Observed Vestibular Schwannoma. ( 30931224 )
2019
50
Hearing Preservation in Stereotactic Radiosurgery for Vestibular Schwannoma. ( 30931223 )
2019

Variations for Acoustic Neuroma

Expression for Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for Acoustic Neuroma

Pathways related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.47 ERCC4 ERCC5 PCNA XRCC1
2
Show member pathways
12.44 APEX1 ERCC4 ERCC5 PCNA XRCC1 XRCC3
3
Show member pathways
11.93 ERCC4 PCNA XRCC3
4 11.93 APEX1 ERCC4 PCNA XRCC1
5 11.66 APEX1 TGFB1 TGIF1
6
Show member pathways
11.63 APEX1 ERCC4 ERCC5 PCNA XRCC1
7 11.58 APEX1 AQP1 TGFB1
8
Show member pathways
11.5 ERCC4 ERCC5 PCNA
9 11.28 APEX1 TGFB1 TGIF1
10 11 NF1 TGFB1

GO Terms for Acoustic Neuroma

Cellular components related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.73 APEX1 AQP1 BICRA ERCC4 ERCC5 NF1
2 replication fork GO:0005657 9.32 PCNA XRCC3
3 nucleotide-excision repair complex GO:0000109 9.26 ERCC4 ERCC5
4 ERCC4-ERCC1 complex GO:0070522 9.16 ERCC4 XRCC1
5 nuclear chromosome, telomeric region GO:0000784 9.02 APEX1 ERCC4 PCNA XRCC1 XRCC3

Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.8 NF1 NF2 TGFB1
2 response to hypoxia GO:0001666 9.79 NF1 TGFB1 XRCC1
3 response to organic substance GO:0010033 9.73 TGFB1 XRCC1 XRCC3
4 cellular response to DNA damage stimulus GO:0006974 9.73 APEX1 ERCC4 ERCC5 PCNA XRCC1 XRCC3
5 double-strand break repair via homologous recombination GO:0000724 9.71 ERCC4 XRCC1 XRCC3
6 cellular response to hydrogen peroxide GO:0070301 9.69 APEX1 AQP1 PCNA
7 cellular response to UV GO:0034644 9.67 AQP1 ERCC4 PCNA
8 base-excision repair GO:0006284 9.64 APEX1 XRCC1
9 liver regeneration GO:0097421 9.64 PCNA TGFB1
10 cellular response to dexamethasone stimulus GO:0071549 9.63 AQP1 TGFB1
11 telomere maintenance GO:0000723 9.63 APEX1 ERCC4 PCNA
12 negative regulation of MAPK cascade GO:0043409 9.62 NF1 NF2
13 cell-cell junction organization GO:0045216 9.61 NF2 TGFB1
14 nucleotide-excision repair, DNA gap filling GO:0006297 9.61 PCNA XRCC1
15 negative regulation of cell-matrix adhesion GO:0001953 9.6 NF1 NF2
16 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.59 ERCC4 ERCC5
17 negative regulation of cell-cell adhesion GO:0022408 9.58 NF2 TGFB1
18 lens fiber cell differentiation GO:0070306 9.58 NF2 TGFB1
19 UV protection GO:0009650 9.57 ERCC4 ERCC5
20 response to cholesterol GO:0070723 9.55 ABCA2 TGFB1
21 nucleotide-excision repair, DNA incision GO:0033683 9.54 ERCC4 ERCC5 PCNA
22 negative regulation of neuroblast proliferation GO:0007406 9.52 NF1 TGFB1
23 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.5 ERCC4 ERCC5 PCNA
24 nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006295 9.48 ERCC4 ERCC5
25 transcription-coupled nucleotide-excision repair GO:0006283 9.46 ERCC4 ERCC5 PCNA XRCC1
26 negative regulation of protection from non-homologous end joining at telomere GO:1905765 9.43 ERCC4 XRCC1
27 DNA repair GO:0006281 9.43 APEX1 ERCC4 ERCC5 PCNA XRCC1 XRCC3
28 telomeric DNA-containing double minutes formation GO:0061819 9.4 ERCC4 XRCC1
29 response to drug GO:0042493 9.1 ABCA2 APEX1 AQP1 TGFB1 TGIF1 XRCC1

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclease activity GO:0004518 9.54 APEX1 ERCC4 ERCC5
2 protein N-terminus binding GO:0047485 9.5 ERCC4 ERCC5 TGFB1
3 endonuclease activity GO:0004519 9.43 APEX1 ERCC4 ERCC5
4 3' overhang single-stranded DNA endodeoxyribonuclease activity GO:1990599 9.16 ERCC4 XRCC1
5 endodeoxyribonuclease activity GO:0004520 9.13 APEX1 ERCC4 ERCC5
6 damaged DNA binding GO:0003684 8.92 APEX1 ERCC4 PCNA XRCC1
7 protein binding GO:0005515 10.18 APEX1 AQP1 BICRA ERCC4 ERCC5 NF1

Sources for Acoustic Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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