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MIFTS: 56

Acoustic Neuroma

Categories: Cancer diseases, Ear diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Acoustic Neuroma

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MalaCards integrated aliases for Acoustic Neuroma:

Name: Acoustic Neuroma 12 74 20 58 42 15 71
Vestibular Schwannoma 12 20 58 15
Cerebellopontine Angle Tumor 20 71
Acoustic Neurilemoma 20 58
Acoustic Neurinoma 20 58
Neurinoma of the Acoustic Nerve 20
Vestibular Neurilemmoma 12
Neuroma, Acoustic 44
Neuroma Acoustic 54
Acoustic Tumor 20

Characteristics:

Orphanet epidemiological data:

58
vestibular schwannoma
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases Ear diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12689
MeSH 44 D009464
NCIt 50 C3276
SNOMED-CT 67 269643009
ICD10 via Orphanet 33 D33.3
UMLS via Orphanet 72 C0027859
Orphanet 58 ORPHA252175
UMLS 71 C0027859 C0474740
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Summaries for Acoustic Neuroma

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MedlinePlus : 42 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. The tumor usually grows slowly. As it grows, it presses against the hearing and balance nerves. At first, you may have no symptoms or mild symptoms. They can include Loss of hearing on one side Ringing in ears Dizziness and balance problems The tumor can also eventually cause numbness or paralysis of the face. If it grows large enough, it can press against the brain, becoming life-threatening. Acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. Ear exams, hearing tests, and scans can show if you have it. If the tumor stays small, you may only need to have it checked regularly. If you do need treatment, surgery and radiation are options. If the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. NIH: National Institute on Deafness and Communication Disorders

MalaCards based summary : Acoustic Neuroma, also known as vestibular schwannoma, is related to neuroma and neurofibromatosis, and has symptoms including seizures, tremor and back pain. An important gene associated with Acoustic Neuroma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Chks in Checkpoint Regulation. The drugs Lapatinib and Sirolimus have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and endothelial, and related phenotypes are homeostasis/metabolism and behavior/neurological

GARD : 20 The following summary is from Orphanet, a European reference portal for information on rare diseases and orphan drugs.Orpha Number: 252175DefinitionVestibular schwannoma is a rare tumor of the posterior fossa originating in the Schwann cells of the vestibular transitional zone of the vestibulocochlear nerve that can be benign, small, slow growing and asymptomatic or large, faster growing and aggressive and potentially fatal, presenting with symptoms of hearing and balance impairment, vertigo, ataxia, headache and fifth, sixth or seventh cranial nerve dysfunction and facial numbness.Visit the Orphanet disease page for more resources.

Wikipedia : 74 A vestibular schwannoma (VS) is a benign primary intracranial tumor of the myelin-forming cells of the... more...

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Related Diseases for Acoustic Neuroma

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Diseases related to Acoustic Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 373)
# Related Disease Score Top Affiliating Genes
1 neuroma 31.1 TGFB1 NF2 NF1 MGMT ERCC2 BICRA
2 neurofibromatosis 30.9 RDX NF2 NF1 MSN
3 spinal meningioma 30.8 NF2 NF1 LZTR1
4 neurilemmomatosis 30.4 NF2 NF1 LZTR1
5 communicating hydrocephalus 30.3 TGFB1 AQP4 AQP1
6 olfactory groove meningioma 30.2 NF2 LZTR1
7 pathologic nystagmus 30.2 RDX MSN EZR
8 obstructive hydrocephalus 30.2 NF2 NF1 AQP4 AQP1
9 neurofibromatosis, type ii 30.2 RDX NF2 NF1 MSN EZR
10 meningioma, familial 30.1 RDX PCNA NF2 NF1 MSN EZR
11 neurilemmoma 29.6 RDX NF2 NF1 MSN MIR96 LZTR1
12 brain cancer 29.6 NF2 NF1 MGMT AQP4
13 pilocytic astrocytoma 29.2 NF1 MGMT ERBB3
14 neurofibromatosis, type iv, of riccardi 11.2
15 neurofibromatosis, type i 11.2
16 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.9
17 facial paralysis 10.8
18 sensorineural hearing loss 10.8
19 branchiootic syndrome 1 10.7
20 headache 10.6
21 secretory meningioma 10.6
22 lymphoplasmacyte-rich meningioma 10.6
23 hydrocephalus 10.6
24 cerebrospinal fluid leak 10.6
25 trigeminal neuralgia 10.4
26 ataxia and polyneuropathy, adult-onset 10.4
27 cerebellopontine angle tumor 10.4
28 xeroderma pigmentosum-cockayne syndrome complex 10.4 ERCC4 ERCC2
29 intracranial meningioma 10.4 PCNA MGMT
30 esophageal atresia/tracheoesophageal fistula 10.4 ERCC4 BRIP1
31 meniere disease 10.3
32 glioma 10.3
33 glial tumor 10.3
34 cerebro-oculo-facio-skeletal syndrome 10.3 ERCC4 ERCC2
35 otosclerosis 10.3
36 meningitis 10.3
37 xeroderma pigmentosum, complementation group d 10.3 ERCC4 ERCC2 APEX1
38 xeroderma pigmentosum, complementation group g 10.3 ERCC4 ERCC2 APEX1
39 glioblastoma 10.3
40 47,xyy 10.3
41 sudden sensorineural hearing loss 10.3
42 epidermoid cysts 10.2
43 sarcoma 10.2
44 normal pressure hydrocephalus 10.2
45 spindle cell sarcoma 10.2
46 subependymoma 10.2 AQP4 AQP1
47 myoclonus and ataxia 10.2
48 arachnoid cysts, intracranial 10.2
49 herpes simplex 10.2
50 bacterial meningitis 10.2

Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to Acoustic Neuroma
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Symptoms & Phenotypes for Acoustic Neuroma

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UMLS symptoms related to Acoustic Neuroma:


seizures, tremor, back pain, headache, syncope, tinnitus, pain, chronic pain, sciatica, snoring, sore throat, coughing, vertigo/dizziness, equilibration disorder, sleeplessness

MGI Mouse Phenotypes related to Acoustic Neuroma:

46 (show all 12)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.36 ABCA2 APEX1 AQP1 AQP4 AQP6 BRIP1
2 behavior/neurological MP:0005386 10.29 ABCA2 AQP1 AQP4 BRIP1 ERBB3 ERCC2
3 growth/size/body region MP:0005378 10.29 ABCA2 APEX1 AQP1 AQP4 ERBB3 ERCC2
4 endocrine/exocrine gland MP:0005379 10.24 APEX1 AQP1 AQP4 BRIP1 ERBB3 ERCC2
5 mortality/aging MP:0010768 10.24 ABCA2 APEX1 AQP1 AQP4 ERBB3 ERCC2
6 immune system MP:0005387 10.17 APEX1 AQP1 AQP4 ERBB3 ERCC2 EZR
7 nervous system MP:0003631 10 ABCA2 AQP1 AQP4 BRIP1 ERBB3 ERCC2
8 liver/biliary system MP:0005370 9.95 APEX1 BRIP1 ERCC4 NF1 NF2 RDX
9 neoplasm MP:0002006 9.92 APEX1 BRIP1 ERBB3 ERCC2 MGMT NF1
10 reproductive system MP:0005389 9.85 ABCA2 APEX1 AQP1 BRIP1 ERCC2 NF1
11 respiratory system MP:0005388 9.56 AQP1 AQP4 ERBB3 MGMT MSN NF1
12 vision/eye MP:0005391 9.32 AQP1 AQP4 AQP6 BRIP1 ERCC2 EZR
Sources

Drugs & Therapeutics for Acoustic Neuroma

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Drugs for Acoustic Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 44)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lapatinib Approved, Investigational Phase 2 231277-92-2, 388082-78-8 208908 9941095
2
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030
3
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
4
Crizotinib Approved Phase 2 877399-52-5 11626560 10366136 10366137 10366138 10366139 10366140 10366141
5
Bevacizumab Approved, Investigational Phase 2 216974-75-3
6
Everolimus Approved Phase 2 159351-69-6 6442177 70789204
7
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
8 Endostatins Phase 2 71581480
9 Immunoglobulins Phase 2
10 Antibodies Phase 2
11 Antibodies, Monoclonal Phase 2
12 Immunoglobulins, Intravenous Phase 2
13 Anti-Inflammatory Agents Phase 2
14 Analgesics, Non-Narcotic Phase 2
15 Platelet Aggregation Inhibitors Phase 2
16 Cyclooxygenase Inhibitors Phase 2
17 Fibrinolytic Agents Phase 2
18 Anti-Inflammatory Agents, Non-Steroidal Phase 2
19 Antirheumatic Agents Phase 2
20 Analgesics Phase 2
21 Antipyretics Phase 2
22 Angiogenesis Inhibitors Phase 2
23 Antineoplastic Agents, Immunological Phase 2
24 Immunosuppressive Agents Phase 2
25 Immunologic Factors Phase 2
26 Protein Kinase Inhibitors Phase 2
27 Mitogens Phase 2
28 Endothelial Growth Factors Phase 2
29
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
30
Triamcinolone Approved, Vet_approved Phase 1 124-94-7 31307
31 Alkylating Agents Phase 1
32 triamcinolone acetonide Phase 1
33 Hormones Phase 1
34 Hormone Antagonists Phase 1
35 Triamcinolone hexacetonide Phase 1
36 glucocorticoids Phase 1
37 Triamcinolone diacetate Phase 1
38
tannic acid Approved 1401-55-4
39
Benzocaine Approved, Investigational 1994-09-7, 94-09-7 2337
40
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
41 Neuromuscular Blocking Agents
42 Neuromuscular Nondepolarizing Agents
43 Anesthetics
44 Histone Deacetylase Inhibitors Early Phase 1

Interventional clinical trials:

(show top 50) (show all 67)
# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With Definite Remaining Vestibular Function Withdrawn NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Vestibular Schwannoma Surgery in Patients With no Measurable Remaining Vestibular Function Withdrawn NCT02415257 Phase 4 Gentamicin
3 Randomized Comparison of Steretotactic Radiosurgery and Hypofractionated Steretotactic Radiotherapy in the Treatment of Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Kan tumorvækst Forudsiges Ved RGD-PET/MR af Vestibularis Schwannomer? Unknown status NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
5 Icotinib Hydrochloride Tablets Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
6 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
7 Recombinant Human Endostatin Injection Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors by Continuous Intravenous Pumping Completed NCT02104323 Phase 2 Endostatin
8 Phase 2 Study of Bevacizumab in Children and Adults With Neurofibromatosis Type 2 and Symptomatic Vestibular Schwannoma Completed NCT01207687 Phase 2
9 A Single Arm, Single Center, Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Completed NCT01490476 Phase 2 RAD001
10 Phase II Trial of Bevacizumab in Patients With Recurrent or Progressive Meningiomas Completed NCT01125046 Phase 2
11 Phase II Study of Lapatinib in Children and Adults With Neurofibromatosis Type 2(NF2) and NF2-related Tumors Completed NCT00973739 Phase 2 Lapatinib
12 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
13 Prospective, Randomized, Placebo-Controlled Phase II Trial of Aspirin for Vestibular Schwannomas Recruiting NCT03079999 Phase 2 Aspirin;Placebo
14 Open-label, Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT04283669 Phase 2 Crizotinib
15 Innovative Trial for Understanding the Impact of Targeted Therapies in NF2 (INTUITT-NF2) Recruiting NCT04374305 Phase 2 Brigatinib
16 Phase 2 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
17 A Single Arm, Monocenter Phase II Trial of RAD001 as Monotherapy in the Treatment of Neurofibromatosis Type 2 - Related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
18 Phase II Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
19 Open-label, Phase 2 Study of Bevacizumab in Children and Young Adults With Neurofibromatosis 2 and Progressive Vestibular Schwannomas That Are Poor Candidates for Standard Treatment With Surgery or Radiation Active, not recruiting NCT01767792 Phase 2 Bevacizumab
20 Microscopic Fluorescence-guided Vestibular Schwannoma Resection Using Fluorescein Sodium and YELLOW 560 Not yet recruiting NCT04351373 Phase 2 intravenous fluorescein sodium
21 A Phase II Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
22 Phase 1 Trial of RO4929097 in Combination With Standard Radiotherapy and Temozolomide for Newly Diagnosed Malignant Glioma: A Pharmacokinetic and Pharmacodynamic Study Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
23 Triamcinolone Acetonide Levels in Cochlear Perilymph, Lateral Canal and CSF in Patients With Vestibular Schwannomas Recruiting NCT04658836 Phase 1 Triamcinolone Acetonide 40mg/mL
24 Phase I Trial of Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma (Acoustic Neuroma) Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
25 Evaluation of the Influence of Psychological Factors on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT01743248
26 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma : Feasibility Study Unknown status NCT02948790
27 Saccular Dilatation, Endolymphatic Hydrops and Vestibular Schwannoma : is Vertigo Really Correlated to the Tumor ? A Retrospective Study Based on FIESTA-C Sequence Using a 3 Tesla MRI Unknown status NCT03593577
28 Consequence of Unilateral Vestibular Loss on Visual Abilities Unknown status NCT03581331
29 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Unknown status NCT03520829
30 Assessment of the Preoperative Vestibular Rehabilitation Effectiveness on Balance Control Compensation After Vestibular Schwannoma Surgery Unknown status NCT02275325
31 Response Prediction After Gamma Knife Surgery (GKS) in Patients With Vestibular Schwannoma Using Dynamic Contrast-Enhanced (DCE) MR Imaging Unknown status NCT03097822
32 Vertigo Symptoms, Balance and Vestibular Function in Patients With Vestibular Schwannoma Unknown status NCT03346889
33 NF2 Natural History Consortium Unknown status NCT00004483
34 Vegetative Monitoring During Brainstem-associated Surgery Unknown status NCT03666507
35 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
36 Vestibular Evaluation Before and After Treatment of Vestibular Schwannoma. Comparison of Gamma Knife Radiosurgery and Microsurgical Resection Completed NCT03670589
37 Intraoperative Motor Evoked Potential Monitoring of Facial Nerve in Patients Undergoing Cerbellopontine Angle Tumer Resection Using Partial Versus no Neuromuscular Block Completed NCT04148534 Muscle Relaxants, Non Depolarizing
38 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099
39 Assessment of Visual Sensitivity, Psychiatric Profile and Quality of Life Following Vestibular Schwannoma Surgery in Patients Prehabituated by Chemical Vestibular Ablation Completed NCT03638310
40 Exploration and Estimation of Intratumoral Concentration and Activity of Lapatinib in Vivo in Vestibular Schwannomas Completed NCT00863122 Early Phase 1 lapatinib
41 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma With Pretreatment Prehabituation by Chemical Vestibular Ablation Completed NCT02963896 gentamicin
42 Exploring the Activity of RAD001 in Vestibular Schwannomas and Meningiomas Completed NCT01880749 Early Phase 1 RAD001
43 Whole Exome Sequencing (WES) of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Completed NCT03210285
44 Recovery of Visual Acuity in Vestibular Deficits Completed NCT00411216
45 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726
46 Evaluation of Acupuncture Effects for Complications After Surgery of Cerebellopontine Angle Tumor in Skull Base Recruiting NCT04249921
47 Clinical and Radiological Evaluation of Acoustic Neuromas With Spontaneous Shrinkage Recruiting NCT03970681
48 Acoustic Neuroma: Assessing the Quality of Life by the Scale PANQOL of Patients Operated or Supervised Recruiting NCT04004377
49 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859
50 Cochlear Implantation During Vestibular Schwannoma Removal or During Labyrinthectomy Surgery for Treatment of Meniere's Disease Recruiting NCT03795675

Search NIH Clinical Center for Acoustic Neuroma

Cochrane evidence based reviews: neuroma, acoustic

Sources

Genetic Tests for Acoustic Neuroma

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Anatomical Context for Acoustic Neuroma

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MalaCards organs/tissues related to Acoustic Neuroma:

40
Brain, Pituitary, Endothelial, Temporal Lobe, Bone, Eye, Breast
Sources

Publications for Acoustic Neuroma

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Articles related to Acoustic Neuroma:

(show top 50) (show all 4984)
# Title Authors PMID Year
1
Incidental Findings of a Vestibular Schwannoma on 18F-Choline PET/CT. 61 42
33234934 2021
2
Beyond the ABCs: Hearing Loss and Quality of Life in Vestibular Schwannoma. 42 61
33153632 2020
3
Current Management of Large Vestibular Schwannomas for NF2 Patients in a National Reference Center. 42
33270257 2021
4
BDNF mRNA expression is significantly upregulated in vestibular schwannomas and correlates with proliferative activity. 54 61
19937367 2010
5
Merlin knockdown in human Schwann cells: clues to vestibular schwannoma tumorigenesis. 54 61
20195187 2010
6
Pathogenesis of vestibular schwannoma in ring chromosome 22. 54 61
19772601 2009
7
[Expression of S518 phosphorylated Merlin and its interaction with CD44 in vestibular schwannoma]. 54 61
19141242 2008
8
Compensative shuttling of merlin to phosphorylation on serine 518 in vestibular schwannoma. 54 61
17989580 2008
9
Erythropoietin and erythropoietin receptor expression in vestibular schwannoma: potential role in tumor progression. 61 54
17429338 2007
10
[Neurotrophic factor expression in vestibular schwannoma. An overview]. 61 54
16612755 2006
11
[Expression and localization of merlin in vestibular schwannoma]. 61 54
17007372 2006
12
Expression of ABCA2 protein in human vestibular schwannoma and peripheral nerve. 54 61
15850583 2005
13
Co-expression of transforming growth factor-beta1 and glial cell line-derived neurotrophic factor in vestibular schwannoma. 61 54
15129118 2004
14
Gene discovery using a human vestibular schwannoma cDNA library constructed from a patient with neurofibromatosis type 2 (NF2). 61 54
12646839 2003
15
Immunolocalization of erythropoietin and erythropoietin receptor in vestibular schwannoma. 54 61
11349767 2001
16
Establishment of primary vestibular schwannoma cultures from neurofibromatosis type-2 patients. 54 61
10024671 1999
17
Immunoblotting analysis of schwannomin/merlin in human schwannomas. 54 61
9752976 1998
18
Nerve growth factor receptor expression in heterotransplanted vestibular schwannoma in athymic nude mice. 61 54
8820351 1996
19
Molecular genetic analysis of the mechanism of tumorigenesis in acoustic neuroma. 54 61
8217082 1993
20
Electrode Alternative for Eighth Nerve Monitoring During Vestibular Schwannoma Resection. 61
32692872 2021
21
Prediction of Vestibular Schwannoma Enlargement After Radiosurgery Using Tumor Shape and MRI Texture Features. 61
33065598 2021
22
Intracanalicular Vestibular Schwannoma: A Systematic Review and Meta-analysis of Therapeutics Outcomes. 61
33555742 2021
23
Predictors of 30-day postoperative systemic complications in geriatric patients undergoing elective brain tumor surgery. 61
33581794 2021
24
Prognostic Factors for the Outcome of Translabyrinthine Surgery for Vestibular Schwannomas. 61
33165159 2021
25
The most commonly injured nerves at surgery: A comprehensive review. 61
33090551 2021
26
Predicting Functional Outcomes and Length of Stay Following Acoustic Neuroma Resection. 61
32757415 2021
27
Management and Outcomes of Sporadic Vestibular Schwannoma: A Longitudinal Study Over 12 Years. 61
32710655 2021
28
Facial Nerve Neurophysiologic Assessment in Vestibular Schwannoma Removal with Transcanal Approach: A Pilot Clinical Study. 61
33189920 2021
29
A microscope-assisted endoscopic transcanal transpromontorial approach for vestibular schwannoma resection: a preliminary report. 61
33523282 2021
30
The 100 most-cited articles on vestibular schwannoma: historical perspectives, current limitations, and future research directions. 61
33523339 2021
31
Applying artificial intelligence to longitudinal imaging analysis of vestibular schwannoma following radiosurgery. 61
33542422 2021
32
Automated Detection of Vestibular Schwannoma Growth Using a Two-Dimensional U-Net Convolutional Neural Network. 61
32304338 2021
33
Three-Dimensional (3D) Printed Vestibular Schwannoma for Facial Nerve Tractography Validation. 61
33577241 2021
34
Vestibular Schwannoma Measurements-Is Volumetric Analysis Clinically Necessary? 61
33577243 2021
35
Comparison between retrosigmoid and translabyrinthine approaches for large vestibular schwannoma: focus on cerebellar injury and morbidities. 61
31758338 2021
36
Evolution in Management Trends of Sporadic Vestibular Schwannoma in the United States Over the Last Half-century. 61
33229882 2021
37
Cochleo-facial corridor to the vestibule and fundus of the internal auditory canal through oval window: a minimal invasive and cochlea sparing approach. 61
33595698 2021
38
Transient Subacute Facial Nerve Dysfunction After Dual Modality Treatment of Large Vestibular Schwannomas. 61
33229880 2021
39
Flexible endoscopic assistance in the surgical management of vestibular schwannomas. 61
31768695 2021
40
Prospective Study of Disease-Specific Quality-of-Life in Sporadic Vestibular Schwannoma Comparing Observation, Radiosurgery, and Microsurgery. 61
33177408 2021
41
Vibration-induced nystagmus and head impulse test screening for vestibular schwannoma. 61
33583327 2021
42
Predicting Hearing Outcomes in Conservatively Managed Vestibular Schwannoma Patients Utilizing Magnetic Resonance Imaging. 61
33290358 2021
43
Pre-existing Vestibular Symptoms Are Associated With Acute Vestibular Symptoms After Gamma Knife Therapy for Vestibular Schwannoma. 61
33591068 2021
44
A Protective Cap: Fundal Fluid Cap Facilitates a Reduction in Inner Ear Radiation Dose in the Radiosurgical Treatment of Vestibular Schwannoma. 61
33443360 2021
45
Cerebellopontine Angle and Internal Auditory Canal Lipomas: Case Series and Systematic Review. 61
33567134 2021
46
Dissociation of caloric and head impulse tests: a marker of Meniere's disease. 61
31222419 2021
47
Hypercoagulability in Vestibular Schwannoma Surgery. 61
33065597 2021
48
Reliability of Preoperative Prediction of the Location of the Facial Nerve Using Diffusion Tensor Imaging-Fiber Tracking in Vestibular Schwannoma: A Systematic Review and Meta-Analysis. 61
33130136 2021
49
Delayed awakening with apnea as a sign of cerebellar hemorrhage after vestibular schwannoma surgery: A case report. 61
33598233 2021
50
The emerging role of hearing loss rehabilitation in patients with vestibular schwannoma treated with Gamma Knife radiosurgery: literature review. 61
32030543 2021
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Variations for Acoustic Neuroma

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Expression for Acoustic Neuroma

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Search GEO for disease gene expression data for Acoustic Neuroma.
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Pathways for Acoustic Neuroma

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Pathways related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 15)
# Super pathways Score Top Affiliating Genes
1
DNA Double-Strand Break Repair 65
Show member pathways
 12.97 PCNA MGMT ERCC4 ERCC2 BRIP1 APEX1
2
Chks in Checkpoint Regulation 63
Show member pathways
 12.41 PCNA MGMT ERCC4 ERCC2 APEX1
3
MicroRNAs in cancer 36
12.32 RDX MIR96 EZR ERBB3
4
Cytoskeletal Signaling 4
12.3 RDX NF2 MSN EZR
5
Proteoglycans in cancer 36
11.87 TGFB1 RDX MSN EZR ERBB3
6
Nucleotide excision repair 36
Show member pathways
 11.79 PCNA ERCC4 ERCC2
7
Glioblastoma Multiforme 63
11.76 NF2 NF1 MGMT
8
Spinal Cord Injury 1
11.64 TGFB1 AQP4 AQP1 APEX1
9
Tight junction 36
11.58 RDX PCNA NF2 MSN EZR
10
DNA Damage 4
11.57 PCNA MGMT ERCC4 ERCC2 BRIP1 APEX1
11
Endocytic Trafficking of EGFR 63
Show member pathways
 11.5 RDX MSN EZR
12
RhoA signaling pathway 1
11.16 RDX MSN EZR
13
Syndecan-2-mediated signaling events 1
11.02 TGFB1 NF1 EZR
14
G-protein signaling_Rap2B regulation pathway 23
10.78 TGFB1 RDX MSN EZR ERBB3
15
Cytosolic iron-sulfur cluster assembly 65
10.57 ERCC2 BRIP1
Sources

GO Terms for Acoustic Neuroma

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Cellular components related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 basolateral plasma membrane GO:0016323 9.65 MSN EZR ERBB3 AQP4 AQP1
2 apical part of cell GO:0045177 9.62 NF2 MSN EZR AQP1
3 cell periphery GO:0071944 9.58 RDX MSN EZR
4 filopodium GO:0030175 9.46 RDX NF2 MSN EZR
5 uropod GO:0001931 9.43 MSN EZR
6 cell tip GO:0051286 9.37 RDX EZR
7 microvillus GO:0005902 9.26 TGFB1 RDX MSN EZR
8 apical plasma membrane GO:0016324 9.1 RDX MSN EZR ERBB3 AQP6 AQP1

Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 34)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.02 TGFB1 RDX MSN EZR ERBB3
2 response to drug GO:0042493 9.96 TGFB1 MGMT APEX1 ABCA2
3 cellular response to DNA damage stimulus GO:0006974 9.93 PCNA MGMT ERCC4 ERCC2 BRIP1 APEX1
4 heart development GO:0007507 9.92 TGFB1 PCNA NF1 ERBB3
5 DNA repair GO:0006281 9.88 PCNA MGMT ERCC4 ERCC2 BRIP1 APEX1
6 wound healing GO:0042060 9.83 TGFB1 NF1 ERBB3
7 transcription-coupled nucleotide-excision repair GO:0006283 9.79 PCNA ERCC4 ERCC2
8 cellular response to hydrogen peroxide GO:0070301 9.77 PCNA AQP1 APEX1
9 cellular response to cAMP GO:0071320 9.75 EZR AQP1 APEX1
10 cellular response to UV GO:0034644 9.74 PCNA ERCC4 AQP1
11 telomere maintenance GO:0000723 9.73 PCNA ERCC4 APEX1
12 nucleotide-excision repair GO:0006289 9.69 ERCC4 ERCC2 BRIP1
13 nucleotide-excision repair, DNA incision GO:0033683 9.67 PCNA ERCC4 ERCC2
14 establishment of epithelial cell apical/basal polarity GO:0045198 9.66 MSN EZR
15 negative regulation of cell-cell adhesion GO:0022408 9.65 TGFB1 NF2
16 protein kinase A signaling GO:0010737 9.65 RDX EZR
17 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.65 PCNA ERCC4 ERCC2
18 UV protection GO:0009650 9.64 ERCC4 ERCC2
19 response to cholesterol GO:0070723 9.64 TGFB1 ABCA2
20 lens fiber cell differentiation GO:0070306 9.63 TGFB1 NF2
21 multicellular organismal water homeostasis GO:0050891 9.63 AQP4 AQP1
22 gland morphogenesis GO:0022612 9.61 MSN EZR
23 regulation of cell size GO:0008361 9.61 RDX MSN EZR
24 cellular water homeostasis GO:0009992 9.59 AQP4 AQP1
25 negative regulation of neuroblast proliferation GO:0007406 9.58 TGFB1 NF1
26 central nervous system myelin formation GO:0032289 9.55 ERCC2 ABCA2
27 membrane to membrane docking GO:0022614 9.54 MSN EZR
28 establishment of endothelial barrier GO:0061028 9.54 RDX MSN EZR
29 carbon dioxide transport GO:0015670 9.52 AQP6 AQP1
30 water transport GO:0006833 9.5 AQP6 AQP4 AQP1
31 positive regulation of cellular protein catabolic process GO:1903364 9.43 RDX MSN EZR
32 positive regulation of protein localization to early endosome GO:1902966 9.33 RDX MSN EZR
33 positive regulation of early endosome to late endosome transport GO:2000643 9.13 RDX MSN EZR
34 regulation of organelle assembly GO:1902115 8.8 RDX MSN EZR

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 9.62 PCNA EZR ERCC4 ERCC2
2 protein N-terminus binding GO:0047485 9.61 TGFB1 ERCC4 ERCC2
3 cytoskeletal protein binding GO:0008092 9.46 RDX NF2 MSN EZR
4 channel activity GO:0015267 9.43 AQP6 AQP4 AQP1
5 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides GO:0016818 9.4 ERCC2 BRIP1
6 endodeoxyribonuclease activity GO:0004520 9.37 ERCC4 APEX1
7 water channel activity GO:0015250 9.13 AQP6 AQP4 AQP1
8 damaged DNA binding GO:0003684 8.92 PCNA ERCC4 ERCC2 APEX1
Sources

Sources for Acoustic Neuroma

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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