MCID: ACS001
MIFTS: 62

Acoustic Neuroma

Categories: Cancer diseases, Ear diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acoustic Neuroma

MalaCards integrated aliases for Acoustic Neuroma:

Name: Acoustic Neuroma 12 76 53 59 43 15 73
Vestibular Schwannoma 12 53 59 29 15
Cerebellopontine Angle Tumor 53 73
Acoustic Neurilemoma 53 59
Acoustic Neurinoma 53 59
Neurinoma of the Acoustic Nerve 53
Vestibular Neurilemmoma 12
Neuroma, Acoustic 44
Neuroma Acoustic 55
Acoustic Tumor 53

Characteristics:

Orphanet epidemiological data:

59
vestibular schwannoma
Prevalence: 1-9/100000 (Denmark),1-9/100000 (United States),1-9/1000000;

Classifications:

Orphanet: 59  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:12689
MeSH 44 D009464
NCIt 50 C3276
SNOMED-CT 68 985004
Orphanet 59 ORPHA252175
UMLS via Orphanet 74 C0027859
ICD10 via Orphanet 34 D33.3

Summaries for Acoustic Neuroma

MedlinePlus : 43 An acoustic neuroma is a benign tumor that develops on the nerve that connects the ear to the brain. The tumor usually grows slowly. As it grows, it presses against the hearing and balance nerves. At first, you may have no symptoms or mild symptoms. They can include Loss of hearing on one side Ringing in ears Dizziness and balance problems The tumor can also eventually cause numbness or paralysis of the face. If it grows large enough, it can press against the brain, becoming life-threatening. Acoustic neuroma can be difficult to diagnose, because the symptoms are similar to those of middle ear problems. Ear exams, hearing tests, and scans can show if you have it. If the tumor stays small, you may only need to have it checked regularly. If you do need treatment, surgery and radiation are options. If the tumors affect both hearing nerves, it is often because of a genetic disorder called neurofibromatosis. NIH: National Institute on Deafness and Communication Disorders

MalaCards based summary : Acoustic Neuroma, also known as vestibular schwannoma, is related to neurilemmomatosis and neuroma, and has symptoms including seizures, tremor and back pain. An important gene associated with Acoustic Neuroma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are DNA Double-Strand Break Repair and Homologous DNA Pairing and Strand Exchange. The drugs Gentamicins and Anti-Bacterial Agents have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and bone, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Synthetic lethal with MLN4924 (a NAE inhibitor)

Wikipedia : 76 A vestibular schwannoma (VS) is a benign primary intracranial tumor of the myelin-forming cells of the... more...

Related Diseases for Acoustic Neuroma

Diseases related to Acoustic Neuroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 neurilemmomatosis 32.5 NF1 NF2
2 neuroma 32.3 BICRA NF2 TGFB1
3 facial paralysis 31.0 NF2 TGFB1
4 spinal meningioma 30.5 NF1 NF2
5 meningioma, familial 30.4 NF1 NF2 PCNA
6 neurofibrosarcoma 30.4 NF1 NF2
7 neurofibromatosis, type iv, of riccardi 12.3
8 neurofibromatosis, type ii 11.5
9 neurofibromatosis, type i 11.5
10 schwannomatosis 1 11.2
11 schwannomatosis 2 11.2
12 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.6
13 headache 10.5
14 cerebrospinal fluid leak 10.4
15 hydrocephalus 10.3
16 sensorineural hearing loss 10.3
17 meningitis 10.3
18 otosclerosis 10.3
19 glioma 10.3
20 pathologic nystagmus 10.3
21 secretory meningioma 10.2
22 otosclerosis 1 10.2
23 glioblastoma 10.2
24 benign meningioma 10.2 NF2 PCNA
25 heritable pulmonary arterial hypertension 10.2 AQP1 TGFB1
26 malignant ependymoma 10.2 ERCC5 NF2
27 cockayne syndrome a 10.2 ERCC4 ERCC5
28 myoclonus and ataxia 10.2
29 glioblastoma multiforme 10.2
30 depression 10.2
31 neurofibromatosis, familial spinal 10.2 NF1 NF2
32 plexiform schwannoma 10.1 NF1 NF2
33 cerebro-oculo-facio-skeletal syndrome 10.1 ERCC4 ERCC5
34 immature cataract 10.1 NF1 NF2
35 plexiform neurofibroma 10.1 NF1 NF2
36 atypical neurofibroma 10.1 NF1 NF2
37 trigeminal nerve neoplasm 10.1 NF1 NF2
38 neurilemmoma of the fifth cranial nerve 10.1 NF1 NF2
39 amyloid tumor 10.1 NF1 NF2
40 sarcoma 10.1
41 astrocytoma 10.1
42 malignant peripheral nerve sheath tumor 10.1
43 spinal canal and spinal cord meningioma 10.1 NF1 NF2
44 xeroderma pigmentosum, complementation group g 10.1 ERCC4 ERCC5
45 optic nerve neoplasm 10.1 NF1 NF2
46 exophthalmos 10.1 NF1 TGFB1
47 xeroderma pigmentosum, complementation group f 10.1 ERCC4 ERCC5
48 glioma susceptibility 1 10.1
49 trigeminal neuralgia 10.1
50 anxiety 10.1

Graphical network of the top 20 diseases related to Acoustic Neuroma:



Diseases related to Acoustic Neuroma

Symptoms & Phenotypes for Acoustic Neuroma

UMLS symptoms related to Acoustic Neuroma:


seizures, tremor, back pain, pain, headache, tinnitus, syncope, chronic pain, sciatica, snoring, coughing, sore throat, vertigo/dizziness, equilibration disorder, sleeplessness

GenomeRNAi Phenotypes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.73 ERCC4 ERCC5 PCNA RAD51 RAD52 XRCC4
2 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-1 9.64 AQP1 ERCC4 ERCC5 PCNA TGFB1
3 Synthetic lethal with MLN4924 (a NAE inhibitor) GR00250-A-2 9.64 AQP1 ERCC4 ERCC5 PCNA TGFB1 RAD51
4 Reduced mammosphere formation GR00396-S 9.63 ERCC5 PCNA POLB RAD51 RAD52 TGFB1
5 Synthetic lethal with cisplatin GR00101-A-1 8.96 NF2 RAD51

MGI Mouse Phenotypes related to Acoustic Neuroma:

46 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.23 ABCA2 AQP1 ERCC4 ERCC5 NF1 NF2
2 homeostasis/metabolism MP:0005376 10.06 ABCA2 AQP1 ERCC5 NF1 NF2 POLB
3 hematopoietic system MP:0005397 10.03 AQP1 ERCC5 NF1 PCNA POLB RAD52
4 endocrine/exocrine gland MP:0005379 10.02 AQP1 NF1 NF2 PCNA POLB TGFB1
5 immune system MP:0005387 9.97 ERCC5 NF1 NF2 PCNA POLB RAD52
6 mortality/aging MP:0010768 9.93 ABCA2 AQP1 ERCC4 ERCC5 NF1 NF2
7 craniofacial MP:0005382 9.89 NF1 NF2 POLB TGFB1 XRCC4
8 integument MP:0010771 9.8 ERCC5 NF1 NF2 POLB TGFB1 XRCC4
9 liver/biliary system MP:0005370 9.73 ERCC4 ERCC5 NF1 NF2 POLB TGFB1
10 neoplasm MP:0002006 9.35 NF1 NF2 RAD52 TGFB1 XRCC4
11 reproductive system MP:0005389 9.17 ABCA2 AQP1 NF2 PCNA RAD52 TGFB1

Drugs & Therapeutics for Acoustic Neuroma

Drugs for Acoustic Neuroma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 62)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Gentamicins Phase 4,Not Applicable
2 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
3 Anti-Infective Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
4
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
7
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
8
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
9 Antineoplastic Agents, Hormonal Phase 3,Not Applicable
10 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
11 Hormones Phase 3
12 Antiemetics Phase 3
13 Anti-Inflammatory Agents Phase 3,Phase 2
14 Peripheral Nervous System Agents Phase 3,Phase 2
15 Methylprednisolone acetate Phase 3
16 Prednisolone acetate Phase 3
17 Gastrointestinal Agents Phase 3,Not Applicable
18 glucocorticoids Phase 3
19 Hormone Antagonists Phase 3
20 Protective Agents Phase 3
21 Autonomic Agents Phase 3
22 Neuroprotective Agents Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 6442177
25
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 46835353 6436030 5284616
26
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
27
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
28
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
29
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 388082-78-8, 231277-92-2 208908 9941095
30
Lactitol Investigational Phase 2 585-86-4 3871
31 Immunologic Factors Phase 2,Early Phase 1
32 Antibodies Phase 2
33 Angiogenesis Modulating Agents Phase 2,Phase 1
34 Angiogenesis Inhibitors Phase 2,Phase 1
35 Immunoglobulins Phase 2
36 Antibodies, Monoclonal Phase 2
37 Antibiotics, Antitubercular Phase 2,Early Phase 1
38 Immunosuppressive Agents Phase 2,Early Phase 1
39 Antifungal Agents Phase 2,Early Phase 1
40 Endostatins Phase 2 71581480
41 Protein Kinase Inhibitors Phase 2,Early Phase 1
42 Analgesics Phase 2
43 Anti-Inflammatory Agents, Non-Steroidal Phase 2
44 Cyclooxygenase Inhibitors Phase 2
45 Antirheumatic Agents Phase 2
46 Analgesics, Non-Narcotic Phase 2
47 Antipyretics Phase 2
48 Fibrinolytic Agents Phase 2
49 Platelet Aggregation Inhibitors Phase 2
50
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394

Interventional clinical trials:

(show top 50) (show all 62)
# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Unknown status NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
5 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
6 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
7 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2 RAD001
8 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2 Endostatin
9 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
10 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2 Everolimus (RAD001) , Afinitor®
11 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
12 RGD PET/MRI in Sporadic Vestibular Schwannoma Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
13 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
14 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Recruiting NCT02129647 Phase 2 Axitinib
15 Study of Aspirin in Patients With Vestibular Schwannoma Recruiting NCT03079999 Phase 2 Aspirin;Placebo
16 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
17 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Recruiting NCT02934256 Phase 2 Icotinib
18 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2 Bevacizumab
19 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
20 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Active, not recruiting NCT02831257 Phase 2 AZD2014
21 Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas Active, not recruiting NCT01125046 Phase 2
22 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
23 RO4929097, Temozolomide, and Radiation Therapy in Treating Patients With Newly Diagnosed Malignant Glioma Completed NCT01119599 Phase 1 Gamma-Secretase Inhibitor RO4929097;Temozolomide
24 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
25 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
26 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231 Not Applicable
27 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
28 Role of Psychiatric Profile in Prehabituated Patients After Vestibular Schwannoma Surgery Completed NCT03638310 Not Applicable
29 Vestibular Evaluation After Vestibular Schwannoma Treatment Completed NCT03670589
30 Concentration and Activity of Lapatinib in Vestibular Schwannomas Completed NCT00863122 Early Phase 1 lapatinib
31 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896 Not Applicable gentamicin
32 WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Completed NCT03210285
33 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099 Not Applicable
34 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
35 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Completed NCT02811718 Not Applicable
36 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
37 A Family Study of Adults With Glioma Completed NCT00339352
38 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
39 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560 Not Applicable
40 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Recruiting NCT02948790 Not Applicable
41 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Recruiting NCT02275325 Not Applicable
42 Vestibular Outcomes in Vestibular Schwannoma Recruiting NCT03346889
43 Secondary Endolymphatic Hydrops and Vestibular Schwannomas on 3 Tesla MRI Recruiting NCT03593577
44 Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results Recruiting NCT03745560
45 CI Following VS Removal or Labyrinthectomy Recruiting NCT03795675 Not Applicable
46 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726 Not Applicable
47 Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study Recruiting NCT03745534
48 Consequence of Unilateral Vestibular Loss on Visual Abilities Recruiting NCT03581331 Not Applicable
49 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Recruiting NCT03520829
50 Vegetative Monitoring During Brainstem-associated Surgery Recruiting NCT03666507

Search NIH Clinical Center for Acoustic Neuroma

Cochrane evidence based reviews: neuroma, acoustic

Genetic Tests for Acoustic Neuroma

Genetic tests related to Acoustic Neuroma:

# Genetic test Affiliating Genes
1 Vestibular Schwannoma 29

Anatomical Context for Acoustic Neuroma

MalaCards organs/tissues related to Acoustic Neuroma:

41
Brain, Testes, Bone, Pituitary, Lung, Breast, Spinal Cord

Publications for Acoustic Neuroma

Articles related to Acoustic Neuroma:

(show top 50) (show all 1925)
# Title Authors Year
1
Tumor-to-Tumor Metastasis From a Breast Carcinoma to a Vestibular Schwannoma. ( 30531647 )
2019
2
Perioperative Recording of Cochlear Implant Evoked Brain Stem Responses After Removal of the Intralabyrinthine Portion of a Vestibular Schwannoma in a Patient with NF2. ( 30531638 )
2019
3
Risk of posterior semicircular canal trauma when using a retrosigmoid approach for acoustic neuroma surgery and role of endoscopy: An imaging study. ( 29493720 )
2018
4
Acoustic Neuroma Treated with Stereotactic Radiosurgery: Follow-up of 335 Patients. ( 29715569 )
2018
5
Patient Decision Making in Vestibular Schwannoma: A Survey of the Acoustic Neuroma Association. ( 29436268 )
2018
6
Increased sensibility to acute acoustic and blast trauma among patients with acoustic neuroma. ( 29184217 )
2018
7
Cochlea-sparing acoustic neuroma treatment with 4I8 radiation therapy. ( 29904732 )
2018
8
Increased Hospital Surgical Volume Reduces Rate of 30- and 90-Day Readmission After Acoustic Neuroma Surgery. ( 29889284 )
2018
9
Acoustic neuroma quality of life: are we missing the point? ( 29948270 )
2018
10
The medium and long-term effect of electrophysiologic monitoring on the facial nerve function in minimally invasive surgery treating acoustic neuroma. ( 29563978 )
2018
11
Long-term outcome after Gamma Knife radiosurgery for acoustic neuroma of all Koos grades: a single-center study. ( 29498575 )
2018
12
Ophthalmic Complications Following Acoustic Neuroma Resection. ( 29253289 )
2018
13
The impact of acoustic neuroma on long-term quality-of-life outcomes in the United Kingdom. ( 29330600 )
2018
14
Transcanal Transpromontorial Acoustic Neuroma Surgery: Results and Facial Nerve Outcomes. ( 29227438 )
2018
15
Patterns of stereotactic radiotherapy utilization and fractionation for acoustic neuroma in the United States. ( 29988251 )
2018
16
Trough-Shaped Audiograms Are Common in Patients with Acoustic Neuroma and Sudden Sensorineural Hearing Loss. ( 30021194 )
2018
17
Pearls for the middle fossa approach in acoustic neuroma surgery. ( 30024419 )
2018
18
Topical insulin in neurotrophic keratopathy after resection of acoustic neuroma. ( 30025986 )
2018
19
Electrical stimulation-based nerve location prediction for cranial nerve VII localization in acoustic neuroma surgery. ( 30106250 )
2018
20
Non-contrast magnetic resonance imaging for monitoring patients with acoustic neuroma. ( 30117408 )
2018
21
Perioperative Care of the Patient With Acoustic Neuroma. ( 30117553 )
2018
22
Multi-option therapy vs observation for small acoustic neuroma: hearing-focused management. ( 30197430 )
2018
23
The Method for Placement of an Intraoperative Continuous Facial Nerve Stimulating Electrode in Acoustic Neuroma Surgery: Technical Note. ( 30249920 )
2018
24
Primary glioblastoma of the cerebellopontine angle in an adult mimicking an acoustic neuroma. ( 30347301 )
2018
25
Long-Term Tumor Control Rates Following Gamma Knife Radiosurgery for Acoustic Neuroma. ( 30447465 )
2018
26
Incidence of Prolonged Systemic Steroid Treatment after Surgery for Acoustic Neuroma and Its Implications. ( 30456025 )
2018
27
Hearing preservation in small acoustic neuroma: observation or active therapy? Literature review and institutional experience. ( 30535851 )
2018
28
De novo cavernous malformation arising in the wall of vestibular schwannoma following stereotactic radiosurgery: case report and review of the literature. ( 30430258 )
2018
29
Unusual Delayed Presentation of Posterior Reversible Encephalopathy Syndrome Following Vestibular Schwannoma Surgery: A Rare Neurologic Emergency. ( 30261399 )
2018
30
Postoperative headache following treatment of vestibular schwannoma: A literature review. ( 29656878 )
2018
31
Spontaneous Transformation of Vestibular Schwannoma into Malignant Peripheral Nerve Sheath Tumor. ( 30283553 )
2018
32
Unusual discovery of a vestibular schwannoma following eradication therapy for Mycobacterium abscessus. ( 30158267 )
2018
33
Unilateral vestibular schwannoma and meningiomas in a patient with PIK3CA-related segmental overgrowth: Co-occurrence of mosaicism for 2 rare disorders. ( 28737257 )
2018
34
The prevalence of vestibular schwannoma among patients treated as sudden sensorineural hearing loss. ( 30042019 )
2018
35
Cerebral venous sinus thrombosis after vestibular schwannoma surgery: a call for evidence-based management guidelines. ( 29961375 )
2018
36
The tethered effect of vestibular schwannoma tumor shrinkage following stereotactic radiosurgery in secondary trigeminal neuralgia. ( 30553070 )
2018
37
Contralateral trigeminal neuralgia in a rapidly growing vestibular schwannoma: A case report. ( 29107410 )
2018
38
Bilateral Spontaneous Regression of Vestibular Schwannoma in Neurofibromatosis Type 2. ( 29477000 )
2018
39
Contralateral Hearing Loss After Resection of Vestibular Schwannoma in a Patient with Neurofibromatosis 2: Case Report and Literature Review. ( 29902600 )
2018
40
Comparison of cervical vestibular evoked potentials evoked by air-conducted sound and bone-conducted vibration in vestibular Schwannoma patients. ( 30261801 )
2018
41
The proteome of perilymph in patients with vestibular schwannoma. A possibility to identify biomarkers for tumor associated hearing loss? ( 29856847 )
2018
42
A Xenograft Model of Vestibular Schwannoma and Hearing Loss. ( 29557843 )
2018
43
Rapidly growing cystic vestibular schwannoma with sudden onset facial palsy, ten years after subtotal excision. ( 28722232 )
2018
44
Preserved Cochlear CISS Signal is a Predictor for Hearing Preservation in Patients Treated for Vestibular Schwannoma With Stereotactic Radiosurgery. ( 29561382 )
2018
45
Hearing aids in patients with vestibular schwannoma: Interest of the auditory brainstem responses. ( 29575711 )
2018
46
National Trends in Vestibular Schwannoma Surgery: Influence of Patient Characteristics on Outcomes. ( 29584554 )
2018
47
Postoperative Tinnitus After Vestibular Schwannoma Surgery Depends on Preoperative Tinnitus and Both Pre- and Postoperative Hearing Function. ( 29593635 )
2018
48
The Role of Fast Imaging Employing Steady-State Acquisition (FIESTA) Magnetic Resonance Imaging for Assessment of Delayed Enhancement of Fat Graft Packing on Postoperative Imaging After Vestibular Schwannoma Surgery. ( 29605696 )
2018
49
Place of Gamma Knife Stereotactic Radiosurgery in Grade 4 Vestibular Schwannoma Based on Case Series of 86 Patients with Long-Term Follow-Up. ( 29614352 )
2018
50
Computational repositioning and preclinical validation of mifepristone for human vestibular schwannoma. ( 29615643 )
2018

Variations for Acoustic Neuroma

Expression for Acoustic Neuroma

Search GEO for disease gene expression data for Acoustic Neuroma.

Pathways for Acoustic Neuroma

Pathways related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 ERCC4 ERCC5 PCNA POLB RAD51 RAD52
2
Show member pathways
11.76 ERCC4 PCNA RAD51 RAD52
3
Show member pathways
11.71 ERCC4 ERCC5 PCNA POLB RAD51 XRCC4
4
Show member pathways
11.5 ERCC4 ERCC5 PCNA
5 11.18 PCNA POLB RAD51
6 10.95 NF1 TGFB1
7 10.83 PCNA RAD51
8 10.78 ERCC4 POLB

GO Terms for Acoustic Neuroma

Cellular components related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.4 AQP1 BICRA ERCC4 ERCC5 NF1 NF2
2 nuclear chromosome, telomeric region GO:0000784 9.33 ERCC4 PCNA RAD51
3 condensed chromosome GO:0000793 9.26 RAD51 XRCC4
4 nucleotide-excision repair complex GO:0000109 8.96 ERCC4 ERCC5

Biological processes related to Acoustic Neuroma according to GeneCards Suite gene sharing:

(show all 28)
# Name GO ID Score Top Affiliating Genes
1 regulation of cell proliferation GO:0042127 9.79 NF1 NF2 TGFB1
2 DNA recombination GO:0006310 9.73 RAD51 RAD52 XRCC4
3 double-strand break repair via homologous recombination GO:0000724 9.65 ERCC4 RAD51 RAD52
4 liver regeneration GO:0097421 9.64 PCNA TGFB1
5 cellular response to dexamethasone stimulus GO:0071549 9.63 AQP1 TGFB1
6 cellular response to ionizing radiation GO:0071479 9.63 RAD51 TGFB1
7 transcription-coupled nucleotide-excision repair GO:0006283 9.63 ERCC4 ERCC5 PCNA
8 replication fork processing GO:0031297 9.62 PCNA RAD51
9 negative regulation of MAPK cascade GO:0043409 9.61 NF1 NF2
10 cell-cell junction organization GO:0045216 9.61 NF2 TGFB1
11 nucleotide-excision repair, DNA gap filling GO:0006297 9.6 PCNA POLB
12 negative regulation of cell-matrix adhesion GO:0001953 9.59 NF1 NF2
13 nucleotide-excision repair, preincision complex stabilization GO:0006293 9.58 ERCC4 ERCC5
14 lymph node development GO:0048535 9.58 POLB TGFB1
15 cellular response to UV GO:0034644 9.58 AQP1 ERCC4 PCNA
16 negative regulation of cell-cell adhesion GO:0022408 9.57 NF2 TGFB1
17 lens fiber cell differentiation GO:0070306 9.55 NF2 TGFB1
18 UV protection GO:0009650 9.54 ERCC4 ERCC5
19 response to cholesterol GO:0070723 9.52 ABCA2 TGFB1
20 salivary gland morphogenesis GO:0007435 9.51 POLB TGFB1
21 cellular response to DNA damage stimulus GO:0006974 9.5 ERCC4 ERCC5 PCNA POLB RAD51 RAD52
22 mitotic recombination GO:0006312 9.49 RAD51 RAD52
23 negative regulation of neuroblast proliferation GO:0007406 9.43 NF1 TGFB1
24 nucleotide-excision repair, DNA incision GO:0033683 9.43 ERCC4 ERCC5 PCNA
25 DNA recombinase assembly GO:0000730 9.37 RAD51 RAD52
26 nucleotide-excision repair, DNA incision, 5'-to lesion GO:0006296 9.33 ERCC4 ERCC5 PCNA
27 nucleotide-excision repair, DNA incision, 3'-to lesion GO:0006295 9.32 ERCC4 ERCC5
28 DNA repair GO:0006281 9.17 ERCC4 ERCC5 PCNA POLB RAD51 RAD52

Molecular functions related to Acoustic Neuroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein C-terminus binding GO:0008022 9.63 ERCC4 RAD51 XRCC4
2 enzyme binding GO:0019899 9.62 PCNA POLB RAD51 TGFB1
3 identical protein binding GO:0042802 9.5 AQP1 ERCC4 PCNA RAD51 RAD52 TGFB1
4 protein N-terminus binding GO:0047485 9.43 ERCC4 ERCC5 TGFB1
5 DNA polymerase binding GO:0070182 9.4 PCNA RAD51
6 endodeoxyribonuclease activity GO:0004520 9.37 ERCC4 ERCC5
7 damaged DNA binding GO:0003684 9.33 ERCC4 PCNA POLB
8 single-stranded DNA binding GO:0003697 8.92 ERCC4 ERCC5 RAD51 RAD52
9 protein binding GO:0005515 10.21 AQP1 BICRA ERCC4 ERCC5 NF1 NF2

Sources for Acoustic Neuroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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