AAT
MCID: ACQ041
MIFTS: 20

Acquired Amegakaryocytic Thrombocytopenia (AAT)

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acquired Amegakaryocytic Thrombocytopenia

MalaCards integrated aliases for Acquired Amegakaryocytic Thrombocytopenia:

Name: Acquired Amegakaryocytic Thrombocytopenia 20 71
Acquired Pure Megakaryocytic Aplasia 20 71
Severe Thrombocytopenia and Selective, Marked Decrease or Absence of Megakaryocytes 20
Aat 20

Classifications:



External Ids:

UMLS 71 C2931757 C2931759

Summaries for Acquired Amegakaryocytic Thrombocytopenia

GARD : 20 Acquired amegakaryocytic thrombocytopenia is a rare blood disorder that causes severe thrombocytopenia with no other blood abnormalities. It is so named because the level of large bone marrow cells that produce platelets, called megakaryocytes, are significantly lower or absent. Signs and symptoms of the condition include prolonged bleeding; easy bruising; rash (pinpoint red spots called petechia); bleeding in the mouth and gums; and/or frequent nosebleeds. There are many potential causes of the condition. Although standard treatment guidelines have not been established, various immunosuppressive treatment approaches have been utilized with success in affected people.

MalaCards based summary : Acquired Amegakaryocytic Thrombocytopenia, also known as acquired pure megakaryocytic aplasia, is related to alpha-1-antitrypsin deficiency and thrombocytopenia. An important gene associated with Acquired Amegakaryocytic Thrombocytopenia is LOC107963955 (BCR-ABL Major-Breakpoint Cluster Region). Affiliated tissues include bone marrow.

Related Diseases for Acquired Amegakaryocytic Thrombocytopenia

Diseases in the Acquired Amegakaryocytic Thrombocytopenia family:

Amegakaryocytic Thrombocytopenia, Congenital

Diseases related to Acquired Amegakaryocytic Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 alpha-1-antitrypsin deficiency 11.8
2 thrombocytopenia 10.8
3 aplastic anemia 10.6
4 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.6
5 purpura 10.5
6 pure red-cell aplasia 10.5
7 red cell aplasia 10.5
8 thymoma, familial 10.4
9 myelodysplastic syndrome 10.4
10 thymoma 10.4
11 thrombocytopenic purpura, autoimmune 10.3
12 myasthenia gravis 10.2
13 adult-onset still's disease 10.2
14 thrombocytopenia due to platelet alloimmunization 10.2
15 acquired pure red cell aplasia 10.2
16 lung disease 10.2
17 aphasia 10.1
18 systemic lupus erythematosus 10.1
19 anemia, autoimmune hemolytic 10.1
20 eosinophilic fasciitis 10.1
21 myelofibrosis 10.1
22 hepatitis c virus 10.1
23 immunodeficiency, common variable, 8, with autoimmunity 10.1
24 deficiency anemia 10.1
25 disease by infectious agent 10.1
26 inflammatory bowel disease 10.1
27 neutropenia 10.1
28 pancytopenia 10.1
29 mononeuritis multiplex 10.1
30 hepatitis c 10.1
31 thrombocytosis 10.1
32 hepatitis 10.1
33 liver disease 10.1
34 hemolytic anemia 10.1
35 lupus erythematosus 10.1
36 evans' syndrome 10.1
37 fasciitis 10.1
38 hemophilia 10.1
39 posttransplant acute limbic encephalitis 10.1
40 rare hemorrhagic disorder 10.1
41 large granular lymphocyte leukemia 10.1
42 trypanosomiasis 10.0
43 amyotrophic lateral sclerosis 1 9.9
44 huntington disease 9.9
45 ataxia and polyneuropathy, adult-onset 9.9
46 pulmonary disease, chronic obstructive 9.9
47 respiratory papillomatosis, juvenile recurrent, congenital 9.9
48 sleeping sickness 9.9
49 lateral sclerosis 9.9
50 hemoglobinopathy 9.9

Graphical network of the top 20 diseases related to Acquired Amegakaryocytic Thrombocytopenia:



Diseases related to Acquired Amegakaryocytic Thrombocytopenia

Symptoms & Phenotypes for Acquired Amegakaryocytic Thrombocytopenia

Drugs & Therapeutics for Acquired Amegakaryocytic Thrombocytopenia

Search Clinical Trials , NIH Clinical Center for Acquired Amegakaryocytic Thrombocytopenia

Genetic Tests for Acquired Amegakaryocytic Thrombocytopenia

Anatomical Context for Acquired Amegakaryocytic Thrombocytopenia

MalaCards organs/tissues related to Acquired Amegakaryocytic Thrombocytopenia:

40
Bone Marrow

Publications for Acquired Amegakaryocytic Thrombocytopenia

Articles related to Acquired Amegakaryocytic Thrombocytopenia:

(show all 43)
# Title Authors PMID Year
1
Acquired amegakaryocytic thrombocytopenia after durvalumab administration. 61
33431742 2021
2
Acquired Amegakaryocytic Thrombocytopenia Misdiagnosed as Immune Thrombocytopenia: A Case Report. 61
33482950 2020
3
Pure red cell aplasia and amegakaryocytic thrombocytopenia in thymoma: The uncharted territory. 61
32274018 2020
4
Acquired Amegakaryocytic Thrombocytopenia in Adult-onset Still's Disease: Successful Combination Therapy with Tocilizumab and Cyclosporine. 61
31391399 2019
5
Acquired Pure Red Cell Aplasia and Acquired Amegakaryocytic Thrombocytopenia Associated With Clonal Expansion of T-Cell Large Granular Lymphocytes in a Patient With Lipopolysaccharide-responsive Beige-like Anchor (LRBA) Protein Deficiency. 61
30188351 2019
6
Acquired amegakaryocytic thrombocytopenia as a rare cause of thrombocytopenia during pregnancy. 61
31229978 2019
7
Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation. 61
29409729 2019
8
A Case of Acquired Amegakaryocytic Thrombocytopenia with Anti-c-mpl Autoantibody: Comparison with Idiopathic Thrombocytopenic Purpura. 61
31132762 2019
9
Marked rebound thrombocytosis in response to glucocorticoids in a patient with acquired amegakaryocytic thrombocytopenia. 61
30416171 2018
10
Acquired Amegakaryocytic Thrombocytopenia and Pure Red Cell Aplasia in Thymoma. 61
29713553 2018
11
Amegakaryocytic Thrombocytopenia and Subsequent Aplastic Anemia Associated with Apparent Epstein-Barr Virus Infection. 61
29301129 2018
12
Acquired amegakaryocytic thrombocytopenia previously diagnosed as idiopathic thrombocytopenic purpura in a patient with hepatitis C virus infection. 61
29085203 2017
13
Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia. 61
28053696 2016
14
Mononeuritis multiplex in acquired amegakaryocytic thrombocytopenia. 61
26752909 2015
15
[Acquired amegakaryocytic thrombocytopenia purpura: think of systemic lupus erythematosus]. 61
26090044 2015
16
Thymoma complicated by acquired amegakaryocytic thrombocytopenia and pure red cell aplasia. 61
25361796 2014
17
"Almost bleeding to death": the conundrum of acquired amegakaryocytic thrombocytopenia. 61
24649385 2014
18
Acquired amegakaryocytic thrombocytopenia in a patient with occupational chemical exposure. 61
22314209 2014
19
Eosinophilic fasciitis with paroxysmal nocturnal hemoglobinuria. 61
22999899 2013
20
Good response to cyclosporin in a child with acquired thrombocytopenic purpura. 61
22170114 2012
21
Acquired amegakaryocytic thrombocytopenia purpura in a Rhesus macaque (Macaca mulatta). 61
22776057 2012
22
Successful treatment of amegakaryocytic thrombocytopenia with azathioprine. 61
21701159 2011
23
Effective use of rituximab for acquired amegakaryocytic thrombocytopenia. 61
20981676 2010
24
Acquired pure megakaryocytic aplasia successfully treated with cyclosporine. 61
27263744 2010
25
Acquired amegakaryocytic thrombocytopenia: potential role of thrombopoietin receptor agonists. 61
21326159 2010
26
[Acquired amegakaryocytic thrombocytopenia after thymectomy in a case of pure red cell aplasia associated with thymoma]. 61
20603583 2010
27
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. 61
17915315 2008
28
Acquired pure megakaryocytic aplasia: report of a single case treated with mycophenolate mofetil. 61
17301968 2007
29
Successful treatment of acquired amegakaryocytic thrombocytopenia with cyclosporine in adult onset Still's disease. 61
16957888 2007
30
Acquired amegakaryocytic thrombocytopenic purpura. 61
16432869 2006
31
Rapid progression of acquired amegakaryocytic thrombocytopenia to myelodysplastic syndrome: case report. 61
27265013 2005
32
Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR T-lymphocytes and a BCR-ABL (p210) fusion transcript. 61
15458517 2004
33
Acquired amegakaryocytic thrombocytopenia--four cases and a literature review. 61
15515801 2004
34
Acquired pure megakaryocytic aplasia: a separate haematological disease entity or a syndrome with multiple causes? 61
15128427 2004
35
[Acquired amegakaryocytic thrombocytopenia: three case reports and a literature review]. 61
15503803 2004
36
Acquired amegakaryocytic thrombocytopenia purpura and eosinophilic fasciitis: a long relapsing and remitting course. 61
14978695 2004
37
Successful treatment of acquired pure red cell aplasia and acquired amegakaryocytic thrombocytopenia with anti-thymocyte globulin. 61
11421300 2001
38
Acquired amegakaryocytic thrombocytopenia treated with allogeneic BMT: a case report and review of the literature. 61
10627644 1999
39
Acquired pure megakaryocytic aplasia report of two cases with long-term responses to antithymocyte globulin and cyclosporine. 61
10577280 1999
40
Rapid progression of acquired amegakaryocytic thrombocytopenia to aplastic anemia. 61
9003837 1997
41
Acquired amegakaryocytic thrombocytopenia: report of a case and review of literature. 61
2690174 1989
42
[Acquired amegakaryocytic thrombocytopenia with rapid progression into aplastic anemia]. 61
6479709 1984
43
Acquired pure megakaryocytic aplasia in course of hepatitis in a patient with immune thrombocytopenic purpura. 61
6441418 1984

Variations for Acquired Amegakaryocytic Thrombocytopenia

Expression for Acquired Amegakaryocytic Thrombocytopenia

Search GEO for disease gene expression data for Acquired Amegakaryocytic Thrombocytopenia.

Pathways for Acquired Amegakaryocytic Thrombocytopenia

GO Terms for Acquired Amegakaryocytic Thrombocytopenia

Sources for Acquired Amegakaryocytic Thrombocytopenia

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57 OMIM® (Updated 05-Mar-2021)
61 PubMed
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68 SNOMED-CT via HPO
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70 Tocris
71 UMLS
72 UMLS via Orphanet
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