Acquired Amegakaryocytic Thrombocytopenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

AAT MCID: ACQ041 MIFTS: 21	Acquired Amegakaryocytic Thrombocytopenia (AAT) Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Rare diseases
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Aliases & Classifications for Acquired Amegakaryocytic Thrombocytopenia

MalaCards integrated aliases for Acquired Amegakaryocytic Thrombocytopenia:

Name: Acquired Amegakaryocytic Thrombocytopenia ⁵² ⁷¹

Acquired Pure Megakaryocytic Aplasia ⁵² ⁷¹

Severe Thrombocytopenia and Selective, Marked Decrease or Absence of Megakaryocytes ⁵²

Aat ⁵²

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases
Anatomical: Immune diseases Blood diseases Bone diseases

See all MalaCards categories (disease lists)

External Ids:

UMLS ⁷¹ C2931757 C2931759

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Summaries for Acquired Amegakaryocytic Thrombocytopenia

NIH Rare Diseases : ⁵² Acquired amegakaryocytic thrombocytopenia is a rare blood disorder that causes severe thrombocytopenia with no other blood abnormalities. It is so named because the level of large bone marrow cells that produce platelets , called megakaryocytes, are significantly lower or absent. Signs and symptoms of the condition include prolonged bleeding; easy bruising; rash (pinpoint red spots called petechia); bleeding in the mouth and gums; and/or frequent nosebleeds. There are many potential causes of the condition. Although standard treatment guidelines have not been established, various immunosuppressive treatment approaches have been utilized with success in affected people.

MalaCards based summary : Acquired Amegakaryocytic Thrombocytopenia, also known as acquired pure megakaryocytic aplasia, is related to alpha-1-antitrypsin deficiency and thrombocytopenia. An important gene associated with Acquired Amegakaryocytic Thrombocytopenia is LOC107963955 (BCR-ABL Major-Breakpoint Cluster Region). Affiliated tissues include bone marrow, bone and t cells.

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Related Diseases for Acquired Amegakaryocytic Thrombocytopenia

Diseases in the Acquired Amegakaryocytic Thrombocytopenia family:

Amegakaryocytic Thrombocytopenia, Congenital

Diseases related to Acquired Amegakaryocytic Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 112)

#	Related Disease	Score
1	alpha-1-antitrypsin deficiency	12.6
2	thrombocytopenia	10.8
3	aplastic anemia	10.6
4	pulmonary fibrosis and/or bone marrow failure, telomere-related, 2	10.6
5	pure red-cell aplasia	10.5
6	purpura	10.5
7	red cell aplasia	10.5
8	heart valve disease	10.5
9	thymoma, familial	10.4
10	thymoma	10.4
11	lung disease	10.4
12	thrombocytopenic purpura, autoimmune	10.4
13	myelodysplastic syndrome	10.4
14	liver disease	10.3
15	systemic lupus erythematosus	10.3
16	myasthenia gravis	10.3
17	anemia, x-linked, with or without neutropenia and/or platelet abnormalities	10.3
18	deficiency anemia	10.3
19	adult-onset still's disease	10.3
20	acquired pure red cell aplasia	10.3
21	aphasia	10.2
22	aortic disease	10.2
23	pulmonary disease, chronic obstructive	10.2
24	trypanosomiasis	10.2
25	anemia, autoimmune hemolytic	10.1
26	eosinophilic fasciitis	10.1
27	hepatitis c virus	10.1
28	immunodeficiency, common variable, 8, with autoimmunity	10.1
29	inflammatory bowel disease	10.1
30	neutropenia	10.1
31	pancytopenia	10.1
32	mononeuritis multiplex	10.1
33	thrombocytosis	10.1
34	hemolytic anemia	10.1
35	lupus erythematosus	10.1
36	evans' syndrome	10.1
37	fasciitis	10.1
38	hemophilia	10.1
39	posttransplant acute limbic encephalitis	10.1
40	large granular lymphocyte leukemia	10.1
41	amyotrophic lateral sclerosis 1	10.1
42	huntington disease	10.1
43	pseudoxanthoma elasticum	10.1
44	ataxia and polyneuropathy, adult-onset	10.1
45	hyperlipoproteinemia, type iii	10.1
46	lipoprotein quantitative trait locus	10.1
47	infective endocarditis	10.1
48	atrial fibrillation	10.1
49	sleeping sickness	10.1
50	thalassemia	10.1

Graphical network of the top 20 diseases related to Acquired Amegakaryocytic Thrombocytopenia:

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Symptoms & Phenotypes for Acquired Amegakaryocytic Thrombocytopenia

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Drugs & Therapeutics for Acquired Amegakaryocytic Thrombocytopenia

Search Clinical Trials , NIH Clinical Center for Acquired Amegakaryocytic Thrombocytopenia

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Genetic Tests for Acquired Amegakaryocytic Thrombocytopenia

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Anatomical Context for Acquired Amegakaryocytic Thrombocytopenia

MalaCards organs/tissues related to Acquired Amegakaryocytic Thrombocytopenia:

⁴⁰

Bone Marrow, Bone, T Cells

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Publications for Acquired Amegakaryocytic Thrombocytopenia

Articles related to Acquired Amegakaryocytic Thrombocytopenia:

(show all 41)

#	Title	Authors	PMID	Year
1	Pure red cell aplasia and amegakaryocytic thrombocytopenia in thymoma: The uncharted territory. ⁶¹	Dragani M...Rege-Cambrin G	32274018	2020
2	Acquired Amegakaryocytic Thrombocytopenia in Adult-onset Still's Disease: Successful Combination Therapy with Tocilizumab and Cyclosporine. ⁶¹	Ichikawa T...Sekijima Y	31391399	2019
3	Acquired Pure Red Cell Aplasia and Acquired Amegakaryocytic Thrombocytopenia Associated With Clonal Expansion of T-Cell Large Granular Lymphocytes in a Patient With Lipopolysaccharide-responsive Beige-like Anchor (LRBA) Protein Deficiency. ⁶¹	Rajpurkar M...Savasan S	30188351	2019
4	Acquired amegakaryocytic thrombocytopenia as a rare cause of thrombocytopenia during pregnancy. ⁶¹	Zimmerman BS...Renteria AS	31229978	2019
5	Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation. ⁶¹	Simkins A...Oo TH	29409729	2019
6	A Case of Acquired Amegakaryocytic Thrombocytopenia with Anti-c-mpl Autoantibody: Comparison with Idiopathic Thrombocytopenic Purpura. ⁶¹	Son B...Kwon J	31132762	2019
7	Marked rebound thrombocytosis in response to glucocorticoids in a patient with acquired amegakaryocytic thrombocytopenia. ⁶¹	Nishino S...Takahashi T	30416171	2018
8	Amegakaryocytic Thrombocytopenia and Subsequent Aplastic Anemia Associated with Apparent Epstein-Barr Virus Infection. ⁶¹	Levy I...Tadmor T	29301129	2018
9	Acquired Amegakaryocytic Thrombocytopenia and Pure Red Cell Aplasia in Thymoma. ⁶¹	Dahal S...Bhattarai B	29713553	2018
10	Acquired amegakaryocytic thrombocytopenia previously diagnosed as idiopathic thrombocytopenic purpura in a patient with hepatitis C virus infection. ⁶¹	Ichimata S...Kanno H	29085203	2017
11	Invasive Thymoma with Pure Red Cell Aplasia and Amegakaryocytic Thrombocytopenia. ⁶¹	Onuki T...Inagaki M	28053696	2016
12	Mononeuritis multiplex in acquired amegakaryocytic thrombocytopenia. ⁶¹	Khan F...Mukundan L	26752909	2015
13	[Acquired amegakaryocytic thrombocytopenia purpura: think of systemic lupus erythematosus]. ⁶¹	Ernestho-ghoud IM...Rabenja FR	26090044	2015
14	Thymoma complicated by acquired amegakaryocytic thrombocytopenia and pure red cell aplasia. ⁶¹	Gay CM...Oo TH	25361796	2014
15	"Almost bleeding to death": the conundrum of acquired amegakaryocytic thrombocytopenia. ⁶¹	Brown GE...Krishnadasan R	24649385	2014
16	Acquired amegakaryocytic thrombocytopenia in a patient with occupational chemical exposure. ⁶¹	Patel M...Devereux L	22314209	2014
17	Eosinophilic fasciitis with paroxysmal nocturnal hemoglobinuria. ⁶¹	de Boysson H...Geffray L	22999899	2013
18	Good response to cyclosporin in a child with acquired thrombocytopenic purpura. ⁶¹	Jain S...Jain S	22170114	2012
19	Acquired amegakaryocytic thrombocytopenia purpura in a Rhesus macaque (Macaca mulatta). ⁶¹	Hanley PW...Barnhart KF	22776057	2012
20	Successful treatment of amegakaryocytic thrombocytopenia with azathioprine. ⁶¹	Chang H...Tang TC	21701159	2011
21	Effective use of rituximab for acquired amegakaryocytic thrombocytopenia. ⁶¹	Deeren D...Dorpe JV	20981676	2010
22	Acquired pure megakaryocytic aplasia successfully treated with cyclosporine. ⁶¹	Omri HE...Baden H	27263744	2010
23	Acquired amegakaryocytic thrombocytopenia: potential role of thrombopoietin receptor agonists. ⁶¹	Lown R...Stasi R	21326159	2010
24	[Acquired amegakaryocytic thrombocytopenia after thymectomy in a case of pure red cell aplasia associated with thymoma]. ⁶¹	Cho AR...Cha EJ	20603583	2010
25	Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. ⁶¹	Lai DW...Paquette RL	17915315	2008
26	Acquired pure megakaryocytic aplasia: report of a single case treated with mycophenolate mofetil. ⁶¹	Bulchandani D...Hinton S	17301968	2007
27	Successful treatment of acquired amegakaryocytic thrombocytopenia with cyclosporine in adult onset Still's disease. ⁶¹	Her MY...Yoo DH	16957888	2007
28	Acquired amegakaryocytic thrombocytopenic purpura. ⁶¹	Agarwal N...Rodgers GM	16432869	2006
29	Rapid progression of acquired amegakaryocytic thrombocytopenia to myelodysplastic syndrome: case report. ⁶¹	Erkurt MA...Aydogdu I	27265013	2005
30	Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR T-lymphocytes and a BCR-ABL (p210) fusion transcript. ⁶¹	Colovic M...Tosic N	15458517	2004
31	Acquired amegakaryocytic thrombocytopenia--four cases and a literature review. ⁶¹	Lachowicz JL...Mooney SC	15515801	2004
32	Acquired pure megakaryocytic aplasia: a separate haematological disease entity or a syndrome with multiple causes? ⁶¹	Felderbauer P...Baier JE	15128427	2004
33	[Acquired amegakaryocytic thrombocytopenia: three case reports and a literature review]. ⁶¹	Antonijevic N...Elezovic I	15503803	2004
34	Acquired amegakaryocytic thrombocytopenia purpura and eosinophilic fasciitis: a long relapsing and remitting course. ⁶¹	Chaudhary UB...Hege KM	14978695	2004
35	Successful treatment of acquired pure red cell aplasia and acquired amegakaryocytic thrombocytopenia with anti-thymocyte globulin. ⁶¹	Ueda K...Hosaka T	11421300	2001
36	Acquired amegakaryocytic thrombocytopenia treated with allogeneic BMT: a case report and review of the literature. ⁶¹	Lonial S...Waller EK	10627644	1999
37	Acquired pure megakaryocytic aplasia report of two cases with long-term responses to antithymocyte globulin and cyclosporine. ⁶¹	Leach JW...George JN	10577280	1999
38	Rapid progression of acquired amegakaryocytic thrombocytopenia to aplastic anemia. ⁶¹	King JA...Latour LF	9003837	1997
39	Acquired amegakaryocytic thrombocytopenia: report of a case and review of literature. ⁶¹	Manoharan A...Sparrow R	2690174	1989
40	[Acquired amegakaryocytic thrombocytopenia with rapid progression into aplastic anemia]. ⁶¹	Meytes D...Fried D	6479709	1984
41	Acquired pure megakaryocytic aplasia in course of hepatitis in a patient with immune thrombocytopenic purpura. ⁶¹	Iannelli S...Petrini MT	6441418	1984

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Genes for Acquired Amegakaryocytic Thrombocytopenia

Genes related to Acquired Amegakaryocytic Thrombocytopenia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	LOC107963955	BCR-ABL Major-Breakpoint Cluster Region	Biological Region	6.87	GeneCards inferred via : Publications (show sections)
2	LOC107980440	ABL Breakpoint Recombination Region	Biological Region	6.87	GeneCards inferred via : Publications (show sections)

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Variations for Acquired Amegakaryocytic Thrombocytopenia

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Expression for Acquired Amegakaryocytic Thrombocytopenia

Search GEO for disease gene expression data for Acquired Amegakaryocytic Thrombocytopenia.

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Pathways for Acquired Amegakaryocytic Thrombocytopenia

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GO Terms for Acquired Amegakaryocytic Thrombocytopenia

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Acquired Amegakaryocytic Thrombocytopenia (AAT)

Aliases & Classifications for Acquired Amegakaryocytic Thrombocytopenia

MalaCards integrated aliases for Acquired Amegakaryocytic Thrombocytopenia:

Classifications:

External Ids:

Summaries for Acquired Amegakaryocytic Thrombocytopenia

Related Diseases for Acquired Amegakaryocytic Thrombocytopenia

Diseases in the Acquired Amegakaryocytic Thrombocytopenia family:

Diseases related to Acquired Amegakaryocytic Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

Graphical network of the top 20 diseases related to Acquired Amegakaryocytic Thrombocytopenia:

Symptoms & Phenotypes for Acquired Amegakaryocytic Thrombocytopenia

Drugs & Therapeutics for Acquired Amegakaryocytic Thrombocytopenia

Genetic Tests for Acquired Amegakaryocytic Thrombocytopenia

Anatomical Context for Acquired Amegakaryocytic Thrombocytopenia

MalaCards organs/tissues related to Acquired Amegakaryocytic Thrombocytopenia:

Publications for Acquired Amegakaryocytic Thrombocytopenia

Articles related to Acquired Amegakaryocytic Thrombocytopenia:

Genes for Acquired Amegakaryocytic Thrombocytopenia

Genes related to Acquired Amegakaryocytic Thrombocytopenia (0 elite genes):

Variations for Acquired Amegakaryocytic Thrombocytopenia

Expression for Acquired Amegakaryocytic Thrombocytopenia

Pathways for Acquired Amegakaryocytic Thrombocytopenia

GO Terms for Acquired Amegakaryocytic Thrombocytopenia

Sources for Acquired Amegakaryocytic Thrombocytopenia