AAT
MCID: ACQ041
MIFTS: 23

Acquired Amegakaryocytic Thrombocytopenia (AAT)

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acquired Amegakaryocytic Thrombocytopenia

MalaCards integrated aliases for Acquired Amegakaryocytic Thrombocytopenia:

Name: Acquired Amegakaryocytic Thrombocytopenia 54 74
Acquired Pure Megakaryocytic Aplasia 54 74
Severe Thrombocytopenia and Selective, Marked Decrease or Absence of Megakaryocytes 54
Aat 54

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Summaries for Acquired Amegakaryocytic Thrombocytopenia

NIH Rare Diseases : 54 Acquired amegakaryocytic thrombocytopenia is a rare blood disorder that causes severe thrombocytopenia with no other blood abnormalities. It is so named because the level of large bone marrow cells that produce platelets, called megakaryocytes, are significantly lower or absent. Signs and symptoms of the condition include prolonged bleeding; easy bruising; rash (pinpoint red spots called petechia); bleeding in the mouth and gums; and/or frequent nosebleeds. There are many potential causes of the condition. Although standard treatment guidelines have not been established, various immunosuppressive treatment approaches have been utilized with success in affected people. 

MalaCards based summary : Acquired Amegakaryocytic Thrombocytopenia, also known as acquired pure megakaryocytic aplasia, is related to alpha-1-antitrypsin deficiency and thrombocytopenia. An important gene associated with Acquired Amegakaryocytic Thrombocytopenia is LOC107963955 (BCR-ABL Major-Breakpoint Cluster Region). Affiliated tissues include bone, bone marrow and t cells.

Related Diseases for Acquired Amegakaryocytic Thrombocytopenia

Diseases in the Acquired Amegakaryocytic Thrombocytopenia family:

Amegakaryocytic Thrombocytopenia, Congenital

Diseases related to Acquired Amegakaryocytic Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 alpha-1-antitrypsin deficiency 12.5
2 thrombocytopenia 10.7
3 heart disease 10.5
4 pure red-cell aplasia 10.4
5 ischemic heart disease 10.4
6 thymoma 10.3
7 purpura 10.3
8 aplastic anemia 10.2
9 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 10.2
10 acquired pure red cell aplasia 10.2
11 aortic disease 10.2
12 trypanosomiasis 10.1
13 thrombocytopenic purpura, autoimmune 10.1
14 eosinophilic fasciitis 10.1
15 hepatitis c virus 10.1
16 myelodysplastic syndrome 10.1
17 hepatitis 10.1
18 leukemia 10.1
19 adult-onset still's disease 10.1
20 mononeuritis multiplex 10.1
21 hepatitis c 10.1
22 thrombocytosis 10.1
23 fasciitis 10.1
24 large granular lymphocyte leukemia 10.1
25 arteries, anomalies of 10.0
26 pulmonary disease, chronic obstructive 10.0
27 myocardial infarction 10.0
28 coronary artery anomaly 10.0
29 liver disease 10.0
30 thalassemia 10.0
31 aphasia 10.0
32 sleeping sickness 10.0
33 adenocarcinoma 10.0
34 bladder adenocarcinoma 10.0
35 lung disease 10.0
36 mycobacterium abscessus 10.0
37 trypanosomiasis, human east-african 10.0
38 multiple sclerosis 9.9
39 schizophrenia 9.9
40 autism 9.9
41 graves disease 1 9.9
42 asthma 9.9
43 allergic rhinitis 9.9
44 alpha-2-macroglobulin deficiency 9.9
45 infective endocarditis 9.9
46 endocarditis 9.9
47 lymphocytic leukemia 9.9
48 dementia 9.9
49 lymphadenitis 9.9
50 rhinitis 9.9

Graphical network of the top 20 diseases related to Acquired Amegakaryocytic Thrombocytopenia:



Diseases related to Acquired Amegakaryocytic Thrombocytopenia

Symptoms & Phenotypes for Acquired Amegakaryocytic Thrombocytopenia

Drugs & Therapeutics for Acquired Amegakaryocytic Thrombocytopenia

Search Clinical Trials , NIH Clinical Center for Acquired Amegakaryocytic Thrombocytopenia

Genetic Tests for Acquired Amegakaryocytic Thrombocytopenia

Anatomical Context for Acquired Amegakaryocytic Thrombocytopenia

MalaCards organs/tissues related to Acquired Amegakaryocytic Thrombocytopenia:

42
Bone, Bone Marrow, T Cells

Publications for Acquired Amegakaryocytic Thrombocytopenia

Articles related to Acquired Amegakaryocytic Thrombocytopenia:

(show all 27)
# Title Authors Year
1
Acquired Amegakaryocytic Thrombocytopenia and Pure Red Cell Aplasia in Thymoma. ( 29713553 )
2018
2
Acquired amegakaryocytic thrombocytopenia and red cell aplasia in a patient with thymoma progressing to aplastic anemia successfully treated with allogenic stem cell transplantation. ( 29409729 )
2018
3
Acquired Pure Red Cell Aplasia and Acquired Amegakaryocytic Thrombocytopenia Associated With Clonal Expansion of T-Cell Large Granular Lymphocytes in a Patient With Lipopolysaccharide-responsive Beige-like Anchor (LRBA) Protein Deficiency. ( 30188351 )
2018
4
Marked rebound thrombocytosis in response to glucocorticoids in a patient with acquired amegakaryocytic thrombocytopenia. ( 30416171 )
2018
5
Acquired amegakaryocytic thrombocytopenia previously diagnosed as idiopathic thrombocytopenic purpura in a patient with hepatitis C virus infection. ( 29085203 )
2017
6
Mononeuritis multiplex in acquired amegakaryocytic thrombocytopenia. ( 26752909 )
2015
7
Acquired amegakaryocytic thrombocytopenia in a patient with occupational chemical exposure. ( 22314209 )
2014
8
"Almost bleeding to death": the conundrum of acquired amegakaryocytic thrombocytopenia. ( 24649385 )
2014
9
Thymoma complicated by acquired amegakaryocytic thrombocytopenia and pure red cell aplasia. ( 25361796 )
2014
10
Acquired amegakaryocytic thrombocytopenia purpura in a Rhesus macaque (Macaca mulatta). ( 22776057 )
2012
11
Acquired amegakaryocytic thrombocytopenia: potential role of thrombopoietin receptor agonists. ( 21326159 )
2010
12
Effective use of rituximab for acquired amegakaryocytic thrombocytopenia. ( 20981676 )
2010
13
Acquired pure megakaryocytic aplasia successfully treated with cyclosporine. ( 27263744 )
2010
14
Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia. ( 17915315 )
2008
15
Successful treatment of acquired amegakaryocytic thrombocytopenia with cyclosporine in adult onset Still's disease. ( 16957888 )
2007
16
Acquired pure megakaryocytic aplasia: report of a single case treated with mycophenolate mofetil. ( 17301968 )
2007
17
Rapid progression of acquired amegakaryocytic thrombocytopenia to myelodysplastic syndrome: case report. ( 27265013 )
2005
18
Acquired amegakaryocytic thrombocytopenia associated with proliferation of gamma/delta TCR T-lymphocytes and a BCR-ABL (p210) fusion transcript. ( 15458517 )
2004
19
Acquired amegakaryocytic thrombocytopenia purpura and eosinophilic fasciitis: a long relapsing and remitting course. ( 14978695 )
2004
20
Acquired amegakaryocytic thrombocytopenia--four cases and a literature review. ( 15515801 )
2004
21
Acquired pure megakaryocytic aplasia: a separate haematological disease entity or a syndrome with multiple causes? ( 15128427 )
2004
22
Successful treatment of acquired pure red cell aplasia and acquired amegakaryocytic thrombocytopenia with anti-thymocyte globulin. ( 11421300 )
2001
23
Acquired amegakaryocytic thrombocytopenia treated with allogeneic BMT: a case report and review of the literature. ( 10627644 )
1999
24
Acquired pure megakaryocytic aplasia report of two cases with long-term responses to antithymocyte globulin and cyclosporine. ( 10577280 )
1999
25
Rapid progression of acquired amegakaryocytic thrombocytopenia to aplastic anemia. ( 9003837 )
1997
26
Acquired amegakaryocytic thrombocytopenia: report of a case and review of literature. ( 2690174 )
1989
27
Acquired pure megakaryocytic aplasia in course of hepatitis in a patient with immune thrombocytopenic purpura. ( 6441418 )
1984

Variations for Acquired Amegakaryocytic Thrombocytopenia

Expression for Acquired Amegakaryocytic Thrombocytopenia

Search GEO for disease gene expression data for Acquired Amegakaryocytic Thrombocytopenia.

Pathways for Acquired Amegakaryocytic Thrombocytopenia

GO Terms for Acquired Amegakaryocytic Thrombocytopenia

Sources for Acquired Amegakaryocytic Thrombocytopenia

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