MCID: ACQ027
MIFTS: 29

Acquired Cutis Laxa

Categories: Skin diseases, Rare diseases, Genetic diseases, Fetal diseases, Neuronal diseases, Eye diseases, Metabolic diseases, Mental diseases, Bone diseases, Gastrointestinal diseases, Nephrological diseases, Cardiovascular diseases

Aliases & Classifications for Acquired Cutis Laxa

MalaCards integrated aliases for Acquired Cutis Laxa:

Name: Acquired Cutis Laxa 59
Cutis Laxa, Acquired Type 73
Cutis Laxa Acquisita 59

Characteristics:

Orphanet epidemiological data:

59
acquired cutis laxa
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA228285
UMLS via Orphanet 74 C0406549
UMLS 73 C0406549

Summaries for Acquired Cutis Laxa

MalaCards based summary : Acquired Cutis Laxa, also known as cutis laxa, acquired type, is related to cutis laxa and myeloma, multiple. An important gene associated with Acquired Cutis Laxa is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include skin, neutrophil and t cells.

Related Diseases for Acquired Cutis Laxa

Diseases in the Cutis Laxa family:

Cutis Laxa, Autosomal Dominant 1 Cutis Laxa, Autosomal Recessive, Type Ia
Cutis Laxa, Autosomal Recessive, Type Iiia Cutis Laxa, Autosomal Recessive, Type Iia
Cutis Laxa, Autosomal Recessive, Type Iib Cutis Laxa, Autosomal Recessive, Type Ic
Cutis Laxa, Autosomal Dominant 2 Cutis Laxa, Autosomal Recessive, Type Ib
Cutis Laxa, Autosomal Recessive, Type Iiib Cutis Laxa, Autosomal Dominant 3
Cutis Laxa, Autosomal Recessive, Type Iic Cutis Laxa, Autosomal Recessive, Type Iid
Autosomal Recessive Cutis Laxa Type Iii Autosomal Recessive Cutis Laxa Type I
Atp6v0a2-Related Cutis Laxa Efemp2-Related Cutis Laxa
Fbln5-Related Cutis Laxa Ltbp4-Related Cutis Laxa
Acquired Cutis Laxa

Diseases related to Acquired Cutis Laxa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 cutis laxa 30.2 ELN FBLN5
2 myeloma, multiple 10.5
3 amyloidosis 10.2
4 arthritis 10.1
5 heavy chain deposition disease 10.1
6 urticaria 10.0
7 dermatitis 10.0
8 al amyloidosis 10.0
9 iga glomerulonephritis 9.9
10 cutaneous mastocytosis 9.9
11 plasmacytoma 9.9
12 systemic lupus erythematosus 9.9
13 granulomatous dermatitis 9.9
14 marshall syndrome 9.9
15 dermatitis herpetiformis 9.9
16 rheumatoid arthritis 9.9
17 vasculitis 9.9
18 lupus erythematosus 9.9
19 dermatitis herpetiformis, familial 9.9
20 alpha-1-antitrypsin deficiency 9.9
21 periodic fever, aphthous stomatitis, pharyngitis and adenitis 9.9
22 inflammatory bowel disease 9.9
23 light and heavy chain deposition disease 9.9
24 lymphoma 9.9
25 nephrotic syndrome 9.9
26 cutis laxa, autosomal dominant 1 9.6 ELN FBLN5
27 mid-dermal elastolysis 9.6 ELN FBLN5
28 supravalvular aortic stenosis 9.5 ELN FBLN5
29 pelvic organ prolapse 9.5 ELN FBLN5
30 pneumothorax 9.4 ELN FBLN5
31 aortic aneurysm 9.2 ELN FBLN5
32 connective tissue disease 9.0 ELN FBLN5

Graphical network of the top 20 diseases related to Acquired Cutis Laxa:



Diseases related to Acquired Cutis Laxa

Symptoms & Phenotypes for Acquired Cutis Laxa

Drugs & Therapeutics for Acquired Cutis Laxa

Search Clinical Trials , NIH Clinical Center for Acquired Cutis Laxa

Genetic Tests for Acquired Cutis Laxa

Anatomical Context for Acquired Cutis Laxa

MalaCards organs/tissues related to Acquired Cutis Laxa:

41
Skin, Neutrophil, T Cells

Publications for Acquired Cutis Laxa

Articles related to Acquired Cutis Laxa:

(show top 50) (show all 66)
# Title Authors Year
1
Acquired Cutis Laxa Associated with Light and Heavy Chain Deposition Disease. ( 29441298 )
2018
2
A case of generalized acquired cutis laxa. ( 29729021 )
2018
3
Case of acquired cutis laxa with preceding urticarial eruption treated by diphenyl sulfone. ( 29782046 )
2018
4
Acquired cutis laxa associated with inflammatory bowel disease, inflammatory arthritis and IgA nephropathy. ( 29536978 )
2018
5
Cutis Laxa Acquisita After Urticarial Vasculitis in SLE Patients. ( 29329127 )
2018
6
Relapsing bullous amyloidosis of the oral mucosa and acquired cutis laxa in a patient with multiple myeloma: a rare triple association. ( 28247530 )
2017
7
Multiple myeloma presenting with acquired cutis laxa and primary systemic amyloidosis. ( 29311044 )
2017
8
RESULTS OF MINIMAL INVASIVE TREATMENT IN LOCALIZED ACQUIRED CUTIS LAXA TYPE 1 AND TYPE 2 - CASE REPORT AND DISCUSSION. ( 28726647 )
2017
9
Generalized acquired cutis laxa type 1: a case report and brief review of literature. ( 27136630 )
2016
10
Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration. ( 27873303 )
2016
11
Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis. ( 25497952 )
2015
12
Acquired cutis laxa associated with cutaneous mastocytosis. ( 26436968 )
2015
13
Generalized acquired cutis laxa with papular lesions. ( 25516168 )
2015
14
Acquired cutis laxa: diagnostic and therapeutic considerations. ( 25027942 )
2014
15
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
16
Acquired cutis laxa of face with multiple myeloma. ( 25201849 )
2014
17
Acral Acquired Cutis Laxa Associated with IgA Multiple Myeloma, Joint Hyperlaxity and Urticarial Neutrophilic Dermatosis. ( 24676529 )
2014
18
Acral localized acquired cutis laxa. ( 23675943 )
2013
19
Emphysema associated with acquired cutis laxa. ( 23506607 )
2013
20
Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy. ( 23694828 )
2013
21
Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. ( 24346874 )
2013
22
Generalized acquired cutis laxa treated with facial plastic surgery. ( 21252033 )
2011
23
Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-I> and IgA-I_ gammopathy following treatment of a nodal plasmacytoma. ( 21422340 )
2011
24
Acquired cutis laxa in a 55-year-old female with multiple myeloma and serologic evidence of systemic lupus erythematosus. ( 21810393 )
2011
25
Part III: cutaneous hypersensitivity during selective serotonin reuptake inhibitor therapy resulting in acquired cutis laxa. ( 21283929 )
2011
26
No mutation of elastin and fibulin-5 genes in a patient with acquired cutis laxa associated with chronic urticaria. ( 20849517 )
2011
27
Ultrastructural demonstration of a relationship between acquired cutis laxa and monoclonal gammopathy. ( 20574607 )
2010
28
Multiple myeloma-associated amyloidosis presenting with acrolocalized acquired cutis laxa. ( 21173333 )
2010
29
Acquired cutis laxa type II (Marshall syndrome) in an 18-month-old child: a case report. ( 20199420 )
2010
30
Clinical presentation of a patient with localized acquired cutis laxa of abdomen: a case report. ( 20585600 )
2010
31
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. ( 19467378 )
2009
32
Acquired cutis laxa in childhood Sweet's syndrome. ( 19706111 )
2009
33
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. ( 19438565 )
2009
34
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. ( 18191696 )
2008
35
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
36
Elastic tissue damage in cephalic acquired cutis laxa. ( 18095996 )
2008
37
Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. ( 16374472 )
2006
38
Cutis laxa acquisita associated with cutaneous mastocytosis. ( 16911382 )
2006
39
[Localized acquired cutis laxa associated with trachyonychia]. ( 16476396 )
2005
40
Acral localized acquired cutis laxa associated with rheumatoid arthritis. ( 11756959 )
2002
41
Ocular findings in cutis laxa acquisita. ( 11897959 )
2002
42
Acquired cutis laxa associated with multiple myeloma. ( 11868975 )
2002
43
Increased fibroblast elastase activity in acquired cutis laxa. ( 10449932 )
1999
44
Post febrile acquired cutis laxa. ( 20885052 )
1999
45
Cutis laxa acquisita: is there any association with Borrelia burgdorferi? ( 10523738 )
1999
46
Acquired cutis laxa associated with cutaneous angiocentric T-cell lymphoma. ( 9372355 )
1997
47
Acrolocalized acquired cutis laxa. ( 8736350 )
1996
48
Generalized acquired cutis laxa associated with coeliac disease: evidence of immunoglobulin A deposits on the dermal elastic fibres. ( 8776377 )
1996
49
Acquired cutis laxa associated with a plasma cell dyscrasia. ( 8902101 )
1996
50
Cutis laxa acquisita associated with multiple myeloma: a case report and review of the literature. ( 8727781 )
1996

Variations for Acquired Cutis Laxa

Expression for Acquired Cutis Laxa

Search GEO for disease gene expression data for Acquired Cutis Laxa.

Pathways for Acquired Cutis Laxa

Pathways related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 ELN FBLN5
2
Show member pathways
10.49 ELN FBLN5

GO Terms for Acquired Cutis Laxa

Cellular components related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 8.96 ELN FBLN5
2 elastic fiber GO:0071953 8.62 ELN FBLN5

Biological processes related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 8.62 ELN FBLN5

Sources for Acquired Cutis Laxa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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