MCID: ACQ027
MIFTS: 25

Acquired Cutis Laxa

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Eye diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Mental diseases, Metabolic diseases, Muscle diseases, Nephrological diseases, Neuronal diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Acquired Cutis Laxa

MalaCards integrated aliases for Acquired Cutis Laxa:

Name: Acquired Cutis Laxa 58
Cutis Laxa, Acquired Type 70
Cutis Laxa Acquisita 58

Characteristics:

Orphanet epidemiological data:

58
acquired cutis laxa
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

UMLS via Orphanet 71 C0406549
Orphanet 58 ORPHA228285
UMLS 70 C0406549

Summaries for Acquired Cutis Laxa

MalaCards based summary : Acquired Cutis Laxa, also known as cutis laxa, acquired type, is related to cutis laxa and autosomal recessive cutis laxa type i. An important gene associated with Acquired Cutis Laxa is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include eye and skin.

Related Diseases for Acquired Cutis Laxa

Diseases in the Cutis Laxa family:

Cutis Laxa, Autosomal Dominant 1 Cutis Laxa, Autosomal Recessive, Type Ia
Cutis Laxa, Autosomal Recessive, Type Iiia Cutis Laxa, Autosomal Recessive, Type Iia
Cutis Laxa, Autosomal Recessive, Type Iib Cutis Laxa, Autosomal Recessive, Type Ic
Cutis Laxa, Autosomal Dominant 2 Cutis Laxa, Autosomal Recessive, Type Ib
Cutis Laxa, Autosomal Recessive, Type Iiib Cutis Laxa, Autosomal Dominant 3
Cutis Laxa, Autosomal Recessive, Type Iic Cutis Laxa, Autosomal Recessive, Type Iid
Autosomal Recessive Cutis Laxa Type Iii Autosomal Recessive Cutis Laxa Type I
Atp6v0a2-Related Cutis Laxa Efemp2-Related Cutis Laxa
Fbln5-Related Cutis Laxa Ltbp4-Related Cutis Laxa
Acquired Cutis Laxa Autosomal Recessive Cutis Laxa Type 2

Diseases related to Acquired Cutis Laxa via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 cutis laxa 31.2 FBLN5 ELN
2 autosomal recessive cutis laxa type i 30.0 FBLN5 ELN
3 pulmonary emphysema 29.9 FBLN5 ELN
4 cutis laxa, autosomal dominant 1 29.7 FBLN5 ELN
5 inguinal hernia 29.6 FBLN5 ELN
6 connective tissue disease 29.3 FBLN5 ELN
7 myeloma, multiple 10.6
8 amyloidosis 10.5
9 urticaria 10.5
10 plasma cell neoplasm 10.4
11 heavy chain deposition disease 10.4
12 glomerulonephritis 10.3
13 skin disease 10.3
14 vasculitis 10.3
15 al amyloidosis 10.3
16 marshall syndrome 10.2
17 dermatitis herpetiformis, familial 10.2
18 chronic urticaria 10.2
19 dermatitis 10.2
20 dermatitis herpetiformis 10.2
21 premature aging 10.2
22 lyme disease 10.1
23 hypocomplementemic urticarial vasculitis 10.1
24 autoimmune disease 10.0
25 carpal tunnel syndrome 10.0
26 systemic lupus erythematosus 10.0
27 mastocytosis, cutaneous 10.0
28 dowling-degos disease 1 10.0
29 sarcoidosis 1 10.0
30 leprosy 3 10.0
31 diabetes and deafness, maternally inherited 10.0
32 neutrophilic dermatosis, acute febrile 10.0
33 alpha-1-antitrypsin deficiency 10.0
34 erythema multiforme 10.0
35 inflammatory bowel disease 10.0
36 x-linked recessive disease 10.0
37 nephrotic syndrome 10.0
38 allergic disease 10.0
39 entropion 10.0
40 polyneuropathy 10.0
41 membranoproliferative glomerulonephritis 10.0
42 iga glomerulonephritis 10.0
43 purpura 10.0
44 mastocytosis 10.0
45 plasmacytoma 10.0
46 granuloma annulare 10.0
47 granulomatous dermatitis 10.0
48 aortitis 10.0
49 monoclonal gammopathy of uncertain significance 10.0
50 arthritis 10.0

Graphical network of the top 20 diseases related to Acquired Cutis Laxa:



Diseases related to Acquired Cutis Laxa

Symptoms & Phenotypes for Acquired Cutis Laxa

Drugs & Therapeutics for Acquired Cutis Laxa

Search Clinical Trials , NIH Clinical Center for Acquired Cutis Laxa

Genetic Tests for Acquired Cutis Laxa

Anatomical Context for Acquired Cutis Laxa

MalaCards organs/tissues related to Acquired Cutis Laxa:

40
Eye, Skin

Publications for Acquired Cutis Laxa

Articles related to Acquired Cutis Laxa:

(show top 50) (show all 97)
# Title Authors PMID Year
1
Successful treatment of acquired cutis laxa with urticarial eruption by diphenyl sulfone. 61
33058256 2021
2
Acral localized acquired cutis laxa as presenting sign of underlying systemic amyloidosis. 61
32594539 2020
3
Acquired cutis laxa associated with neutrophilic urticarial dermatosis. 61
33226126 2020
4
Acquired Cutis Laxa 61
32329984 2020
5
Fractional Carbon Dioxide Laser Treatment for Textural Improvement and Symptomatic Relief of Acquired Cutis Laxa of the Neck. 61
32770692 2020
6
Acquired cutis laxa secondary to Sweet syndrome in a child (Marshall syndrome): A rare case report. 61
31437319 2020
7
Type II acquired cutis laxa associated with recurrent urticarial vasculitis: brief report. 61
31911804 2020
8
Generalized Acquired Cutis Laxa Associated with Monoclonal Gammopathy of Dermatological Significance. 61
32099688 2020
9
Acquired Localized Cutis Laxa: A Case Report and the Role of Plastic Surgery. 61
30745636 2019
10
Acquired Cutis Laxa Presenting as Pedunculated Eyelid Plaques in an Adult. 61
30454716 2018
11
A case of generalized acquired cutis laxa. 61
29729021 2018
12
Case of acquired cutis laxa with preceding urticarial eruption treated by diphenyl sulfone. 61
29782046 2018
13
Acquired cutis laxa associated with inflammatory bowel disease, inflammatory arthritis and IgA nephropathy. 61
29536978 2018
14
Swollen hand joints, arthralgia, photosensitivity and generalized acquired cutis laxa-like presentation of leprosy. 61
30117713 2018
15
Acquired Cutis Laxa Associated with Light and Heavy Chain Deposition Disease. 61
29441298 2018
16
Multiple myeloma presenting with acquired cutis laxa and primary systemic amyloidosis. 61
29311044 2017
17
Relapsing bullous amyloidosis of the oral mucosa and acquired cutis laxa in a patient with multiple myeloma: a rare triple association. 61
28247530 2017
18
RESULTS OF MINIMAL INVASIVE TREATMENT IN LOCALIZED ACQUIRED CUTIS LAXA TYPE 1 AND TYPE 2 - CASE REPORT AND DISCUSSION. 61
28726647 2017
19
Generalized acquired cutis laxa type 1: a case report and brief review of literature. 61
27136630 2016
20
Acquired cutis laxa associated with cutaneous mastocytosis. 61
26436968 2015
21
Generalized acquired cutis laxa with papular lesions. 61
25516168 2015
22
Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis. 61
25497952 2015
23
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. 61
25133950 2014
24
Acral acquired cutis laxa associated with IgA multiple myeloma, joint hyperlaxity and urticarial neutrophilic dermatosis. 61
24676529 2014
25
Acquired cutis laxa: diagnostic and therapeutic considerations. 61
25027942 2014
26
Acquired cutis laxa of face with multiple myeloma. 61
25201849 2014
27
[Acquired cutis laxa associated with monoclonal gammopathy and lambda light chain deposition disease]. 61
24852771 2014
28
Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. 61
24346874 2013
29
Acral localized acquired cutis laxa. 61
23675943 2013
30
Cutis laxa: a report of two interesting cases. 61
23919031 2013
31
Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy. 61
23694828 2013
32
Emphysema associated with acquired cutis laxa. 61
23506607 2013
33
Marshall's syndrome. 61
23739715 2013
34
Acquired cutis laxa in a 55-year-old female with multiple myeloma and serologic evidence of systemic lupus erythematosus. 61
21810393 2011
35
Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-λ and IgA-κ gammopathy following treatment of a nodal plasmacytoma. 61
21422340 2011
36
Part III: cutaneous hypersensitivity during selective serotonin reuptake inhibitor therapy resulting in acquired cutis laxa. 61
21283929 2011
37
No mutation of elastin and fibulin-5 genes in a patient with acquired cutis laxa associated with chronic urticaria. 61
20849517 2011
38
Generalized acquired cutis laxa treated with facial plastic surgery. 61
21252033 2011
39
Multiple myeloma-associated amyloidosis presenting with acrolocalized acquired cutis laxa. 61
21173333 2010
40
Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease. 61
21165224 2010
41
Ultrastructural demonstration of a relationship between acquired cutis laxa and monoclonal gammopathy. 61
20574607 2010
42
Acquired cutis laxa type II (Marshall syndrome) in an 18-month-old child: a case report. 61
20199420 2010
43
Clinical presentation of a patient with localized acquired cutis laxa of abdomen: a case report. 61
20585600 2010
44
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. 61
19438565 2009
45
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. 61
19467378 2009
46
Acquired cutis laxa in childhood Sweet's syndrome. 61
19706111 2009
47
Penicillamine-induced elastosis of the mucosal lip. 61
19293020 2009
48
Generalized cutis laxa and fibrillar glomerulopathy resulting from IgG Deposition in IgG-lambda Monoclonal Gammopathy: pulmonary hemorrhage during stem cell mobilization and complete hematological response with bortezomib and dexamethasone therapy. 61
19018863 2009
49
Acquired cutis laxa associated with heavy chain deposition disease. 61
19119136 2008
50
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. 61
18191696 2008

Variations for Acquired Cutis Laxa

Expression for Acquired Cutis Laxa

Search GEO for disease gene expression data for Acquired Cutis Laxa.

Pathways for Acquired Cutis Laxa

Pathways related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 FBLN5 ELN
2
Show member pathways
10.49 FBLN5 ELN

GO Terms for Acquired Cutis Laxa

Cellular components related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 9.16 FBLN5 ELN
2 extracellular matrix GO:0031012 8.96 FBLN5 ELN
3 elastic fiber GO:0071953 8.62 FBLN5 ELN

Biological processes related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 8.62 FBLN5 ELN

Molecular functions related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix constituent conferring elasticity GO:0030023 8.62 FBLN5 ELN

Sources for Acquired Cutis Laxa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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