MCID: ACQ027
MIFTS: 31

Acquired Cutis Laxa

Categories: Blood diseases, Bone diseases, Cardiovascular diseases, Eye diseases, Fetal diseases, Gastrointestinal diseases, Genetic diseases, Mental diseases, Metabolic diseases, Muscle diseases, Nephrological diseases, Neuronal diseases, Rare diseases, Skin diseases

Aliases & Classifications for Acquired Cutis Laxa

MalaCards integrated aliases for Acquired Cutis Laxa:

Name: Acquired Cutis Laxa 60
Cutis Laxa, Acquired Type 74
Cutis Laxa Acquisita 60

Characteristics:

Orphanet epidemiological data:

60
acquired cutis laxa
Inheritance: Not applicable; Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

UMLS via Orphanet 75 C0406549
Orphanet 60 ORPHA228285
UMLS 74 C0406549

Summaries for Acquired Cutis Laxa

MalaCards based summary : Acquired Cutis Laxa, also known as cutis laxa, acquired type, is related to cutis laxa and myeloma, multiple. An important gene associated with Acquired Cutis Laxa is ELN (Elastin), and among its related pathways/superpathways are Degradation of the extracellular matrix and Elastic fibre formation. Affiliated tissues include skin, neutrophil and t cells.

Related Diseases for Acquired Cutis Laxa

Diseases in the Cutis Laxa family:

Cutis Laxa, Autosomal Dominant 1 Cutis Laxa, Autosomal Recessive, Type Ia
Cutis Laxa, Autosomal Recessive, Type Iiia Cutis Laxa, Autosomal Recessive, Type Iia
Cutis Laxa, Autosomal Recessive, Type Iib Cutis Laxa, Autosomal Recessive, Type Ic
Cutis Laxa, Autosomal Dominant 2 Cutis Laxa, Autosomal Recessive, Type Ib
Cutis Laxa, Autosomal Recessive, Type Iiib Cutis Laxa, Autosomal Dominant 3
Cutis Laxa, Autosomal Recessive, Type Iic Cutis Laxa, Autosomal Recessive, Type Iid
Autosomal Recessive Cutis Laxa Type Iii Autosomal Recessive Cutis Laxa Type I
Atp6v0a2-Related Cutis Laxa Efemp2-Related Cutis Laxa
Fbln5-Related Cutis Laxa Ltbp4-Related Cutis Laxa
Acquired Cutis Laxa

Diseases related to Acquired Cutis Laxa via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 36)
# Related Disease Score Top Affiliating Genes
1 cutis laxa 31.1 ELN FBLN5
2 myeloma, multiple 10.6
3 amyloidosis 10.4
4 arthritis 10.3
5 heavy chain deposition disease 10.3
6 urticaria 10.2
7 dermatitis 10.2
8 al amyloidosis 10.2
9 systemic lupus erythematosus 10.1
10 marshall syndrome 10.1
11 rheumatoid arthritis 10.1
12 leprosy 3 10.1
13 dermatitis herpetiformis, familial 10.1
14 alpha-1-antitrypsin deficiency 10.1
15 inflammatory bowel disease 10.1
16 lymphoma 10.1
17 nephrotic syndrome 10.1
18 iga glomerulonephritis 10.1
19 mastocytosis 10.1
20 plasmacytoma 10.1
21 granulomatous dermatitis 10.1
22 kidney disease 10.1
23 dermatitis herpetiformis 10.1
24 vasculitis 10.1
25 lupus erythematosus 10.1
26 hansen's disease 10.1
27 periodic fever, aphthous stomatitis, pharyngitis and adenitis 10.1
28 light and heavy chain deposition disease 10.1
29 cutis laxa, autosomal dominant 2 9.8 ELN FBLN5
30 mid-dermal elastolysis 9.8 ELN FBLN5
31 autosomal recessive cutis laxa type i 9.8 ELN FBLN5
32 supravalvular aortic stenosis 9.7 ELN FBLN5
33 pelvic organ prolapse 9.7 ELN FBLN5
34 cutis laxa, autosomal dominant 1 9.7 ELN FBLN5
35 aortic aneurysm 9.6 ELN FBLN5
36 connective tissue disease 9.5 ELN FBLN5

Graphical network of the top 20 diseases related to Acquired Cutis Laxa:



Diseases related to Acquired Cutis Laxa

Symptoms & Phenotypes for Acquired Cutis Laxa

Drugs & Therapeutics for Acquired Cutis Laxa

Search Clinical Trials , NIH Clinical Center for Acquired Cutis Laxa

Genetic Tests for Acquired Cutis Laxa

Anatomical Context for Acquired Cutis Laxa

MalaCards organs/tissues related to Acquired Cutis Laxa:

42
Skin, Neutrophil, T Cells, Kidney, Bone, Eye

Publications for Acquired Cutis Laxa

Articles related to Acquired Cutis Laxa:

(show top 50) (show all 69)
# Title Authors Year
1
Acquired Cutis Laxa Associated with Light and Heavy Chain Deposition Disease. ( 29441298 )
2018
2
Acquired cutis laxa associated with inflammatory bowel disease, inflammatory arthritis and IgA nephropathy. ( 29536978 )
2018
3
A case of generalized acquired cutis laxa. ( 29729021 )
2018
4
Case of acquired cutis laxa with preceding urticarial eruption treated by diphenyl sulfone. ( 29782046 )
2018
5
Swollen hand joints, arthralgia, photosensitivity and generalized acquired cutis laxa-like presentation of leprosy. ( 30117713 )
2018
6
Acquired Cutis Laxa Presenting as Pedunculated Eyelid Plaques in an Adult. ( 30454716 )
2018
7
Cutis Laxa Acquisita After Urticarial Vasculitis in SLE Patients. ( 29329127 )
2018
8
Relapsing bullous amyloidosis of the oral mucosa and acquired cutis laxa in a patient with multiple myeloma: a rare triple association. ( 28247530 )
2017
9
RESULTS OF MINIMAL INVASIVE TREATMENT IN LOCALIZED ACQUIRED CUTIS LAXA TYPE 1 AND TYPE 2 - CASE REPORT AND DISCUSSION. ( 28726647 )
2017
10
Multiple myeloma presenting with acquired cutis laxa and primary systemic amyloidosis. ( 29311044 )
2017
11
Cutis laxa acquisita: novel insights into impaired elastic fibre regeneration. ( 27873303 )
2017
12
Generalized acquired cutis laxa type 1: a case report and brief review of literature. ( 27136630 )
2016
13
Acral localized acquired cutis laxa: report of a case associated with inflammatory arthritis. ( 25497952 )
2015
14
Generalized acquired cutis laxa with papular lesions. ( 25516168 )
2015
15
Acquired cutis laxa associated with cutaneous mastocytosis. ( 26436968 )
2015
16
Acral acquired cutis laxa associated with IgA multiple myeloma, joint hyperlaxity and urticarial neutrophilic dermatosis. ( 24676529 )
2014
17
Acquired cutis laxa: diagnostic and therapeutic considerations. ( 25027942 )
2014
18
Acquired cutis laxa associated with heavy chain deposition disease involving dermal elastic fibers. ( 25133950 )
2014
19
Acquired cutis laxa of face with multiple myeloma. ( 25201849 )
2014
20
Emphysema associated with acquired cutis laxa. ( 23506607 )
2013
21
Acral localized acquired cutis laxa. ( 23675943 )
2013
22
Acquired cutis laxa with an interstitial granulomatous reaction associated with IgG lambda monoclonal gammopathy. ( 23694828 )
2013
23
Primary systemic amyloidosis, acquired cutis laxa and cutaneous mucinosis in a patient with multiple myeloma. ( 24346874 )
2013
24
No mutation of elastin and fibulin-5 genes in a patient with acquired cutis laxa associated with chronic urticaria. ( 20849517 )
2011
25
Generalized acquired cutis laxa treated with facial plastic surgery. ( 21252033 )
2011
26
Part III: cutaneous hypersensitivity during selective serotonin reuptake inhibitor therapy resulting in acquired cutis laxa. ( 21283929 )
2011
27
Generalized acquired cutis laxa associated with multiple myeloma with biphenotypic IgG-λ and IgA-κ gammopathy following treatment of a nodal plasmacytoma. ( 21422340 )
2011
28
Acquired cutis laxa in a 55-year-old female with multiple myeloma and serologic evidence of systemic lupus erythematosus. ( 21810393 )
2011
29
Acquired cutis laxa type II (Marshall syndrome) in an 18-month-old child: a case report. ( 20199420 )
2010
30
Ultrastructural demonstration of a relationship between acquired cutis laxa and monoclonal gammopathy. ( 20574607 )
2010
31
Clinical presentation of a patient with localized acquired cutis laxa of abdomen: a case report. ( 20585600 )
2010
32
Multiple myeloma-associated amyloidosis presenting with acrolocalized acquired cutis laxa. ( 21173333 )
2010
33
Localized acquired cutis laxa secondary to interstitial granulomatous dermatitis. ( 19438565 )
2009
34
Acquired cutis laxa following urticarial vasculitis associated with IgA myeloma. ( 19467378 )
2009
35
Acquired cutis laxa in childhood Sweet's syndrome. ( 19706111 )
2009
36
Elastic tissue damage in cephalic acquired cutis laxa. ( 18095996 )
2008
37
Multiple myeloma-associated amyloidosis and acral localized acquired cutis laxa. ( 18191696 )
2008
38
Acquired cutis laxa associated with heavy chain deposition disease. ( 19119136 )
2008
39
Inflammatory destruction of elastic fibers in acquired cutis laxa is associated with missense alleles in the elastin and fibulin-5 genes. ( 16374472 )
2006
40
Cutis laxa acquisita associated with cutaneous mastocytosis. ( 16911382 )
2006
41
[Localized acquired cutis laxa associated with trachyonychia]. ( 16476396 )
2005
42
Acral localized acquired cutis laxa associated with rheumatoid arthritis. ( 11756959 )
2002
43
Acquired cutis laxa associated with multiple myeloma. ( 11868975 )
2002
44
Ocular findings in cutis laxa acquisita. ( 11897959 )
2002
45
Increased fibroblast elastase activity in acquired cutis laxa. ( 10449932 )
1999
46
Post febrile acquired cutis laxa. ( 20885052 )
1999
47
Cutis laxa acquisita: is there any association with Borrelia burgdorferi? ( 10523738 )
1999
48
Acquired cutis laxa associated with cutaneous angiocentric T-cell lymphoma. ( 9372355 )
1997
49
Acrolocalized acquired cutis laxa. ( 8736350 )
1996
50
Generalized acquired cutis laxa associated with coeliac disease: evidence of immunoglobulin A deposits on the dermal elastic fibres. ( 8776377 )
1996

Variations for Acquired Cutis Laxa

Expression for Acquired Cutis Laxa

Search GEO for disease gene expression data for Acquired Cutis Laxa.

Pathways for Acquired Cutis Laxa

Pathways related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.61 ELN FBLN5
2
Show member pathways
10.49 ELN FBLN5

GO Terms for Acquired Cutis Laxa

Cellular components related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.16 ELN FBLN5
2 collagen-containing extracellular matrix GO:0062023 8.96 ELN FBLN5
3 elastic fiber GO:0071953 8.62 ELN FBLN5

Biological processes related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 8.62 ELN FBLN5

Molecular functions related to Acquired Cutis Laxa according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix constituent conferring elasticity GO:0030023 8.62 ELN FBLN5

Sources for Acquired Cutis Laxa

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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