MCID: ACQ042
MIFTS: 44

Acquired Hemophilia a

Categories: Blood diseases, Genetic diseases, Immune diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Acquired Hemophilia a

MalaCards integrated aliases for Acquired Hemophilia a:

Name: Acquired Hemophilia a 53
Acquired Factor Viii Deficiency Disease 29
Acquired Factor Vii Deficiency Disease 73
Acquired Factor Vii Deficiency 53
Factor 8 Deficiency, Acquired 73
Acquired Factor 8 Deficiency 53
Acquired Hemophilia 73

Classifications:



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Summaries for Acquired Hemophilia a

NIH Rare Diseases : 53 Acquired hemophilia A is a bleeding disorder that interferes with the body's blood clotting process. Although the condition can affect people of all ages, it generally occurs in older people (the median age of diagnosis is between 60 and 67 years). Signs and symptoms include prolonged bleeding, frequent nosebleeds, bruising throughout the body, solid swellings of congealed blood (hematomas), hematuria, and gastrointestinal or urologic bleeding. Acquired hemophilia A occurs when the body's immune system attacks and disables a certain protein that helps the blood clot (called coagulation factor VIII). About half of the cases are associated with other conditions, such as pregnancy, autoimmune disease, cancer, skin diseases, or allergic reactions to medications. Treatment is aimed at controlling bleeding episodes and addressing the underlying cause of the condition.

MalaCards based summary : Acquired Hemophilia a, also known as acquired factor viii deficiency disease, is related to factor vii deficiency and hemophilia. An important gene associated with Acquired Hemophilia a is F8 (Coagulation Factor VIII), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Prednisolone phosphate and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include skin, lung and prostate.

Related Diseases for Acquired Hemophilia a

Diseases in the Hemophilia family:

Hemophilia a Hemophilia B
Acquired Hemophilia Acquired Hemophilia a

Diseases related to Acquired Hemophilia a via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 factor vii deficiency 32.4 F3 F8 F9
2 hemophilia 31.2 F3 F8 F9
3 hemophilia a 30.4 F11 F3 F5 F8 F9
4 factor viii deficiency 30.2 F11 F5 F8
5 acquired hemophilia 30.1 F11 F3 F5 F8 F8A1 F9
6 hemarthrosis 29.7 F8 F9
7 thrombosis 29.2 F3 F5 F8 F9
8 von willebrand's disease 28.7 F11 F3 F5 F8 F9
9 fournier gangrene 10.1 F3 F8
10 von willebrand disease, type 1 10.1 F3 F8
11 cardiac tamponade 10.1 F8 F9
12 arthritis 10.1
13 von willebrand disease, type 2 10.0 F3 F8
14 factor v and factor viii, combined deficiency of, 2 10.0 F5 F8
15 thrombasthenia 10.0 F3 F5
16 cerebral sinovenous thrombosis 10.0 F3 F5
17 thrombophlebitis 10.0 F5 F8
18 sagittal sinus thrombosis 10.0 F3 F5
19 catastrophic antiphospholipid syndrome 10.0 F3 F5
20 carotid artery occlusion 10.0 F5 F8
21 antiphospholipid syndrome 10.0 F3 F5
22 post-thrombotic syndrome 10.0 F5 F8
23 rheumatoid arthritis 10.0
24 myeloma, multiple 10.0
25 pancreatitis 10.0
26 peripheral vertigo 10.0 F3 F5
27 blood protein disease 10.0 F3 F5
28 pulmonary artery disease 10.0 F3 F5
29 protein s deficiency 10.0 F3 F5
30 blood platelet disease 10.0 F3 F8
31 intracranial hypertension 9.9 F3 F5
32 inherited blood coagulation disease 9.9 F3 F8 F9
33 placenta disease 9.9 F3 F5
34 protein c deficiency 9.9 F5 F9
35 glanzmann thrombasthenia 9.9 F3 F8 F9
36 lemierre's syndrome 9.9 F11 F3
37 budd-chiari syndrome 9.9 F3 F5
38 systemic lupus erythematosus 9.9
39 prostate cancer 9.9
40 diabetes mellitus 9.9
41 leukemia 9.9
42 autoimmune pancreatitis 9.9
43 bullous pemphigoid 9.9
44 lupus erythematosus 9.9
45 pemphigus 9.9
46 arthropathy 9.9 F8 F9
47 factor xiii deficiency 9.9 F3 F5 F8
48 intracranial thrombosis 9.9 F3 F5 F8
49 colorectal cancer 9.9
50 leukemia, acute myeloid 9.9

Graphical network of the top 20 diseases related to Acquired Hemophilia a:



Diseases related to Acquired Hemophilia a

Symptoms & Phenotypes for Acquired Hemophilia a

Drugs & Therapeutics for Acquired Hemophilia a

Drugs for Acquired Hemophilia a (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2 6055-19-2, 50-18-0 2907
3
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
4
rituximab Approved Phase 3,Phase 2 174722-31-7 10201696
5
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
6
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
7
Prednisone Approved, Vet_approved Phase 2, Phase 3 53-03-2 5865
8
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
9 Coagulants Phase 2, Phase 3,Phase 3
10 Autoantibodies Phase 2, Phase 3
11 Immunoglobulins Phase 2, Phase 3,Phase 3
12 Factor VIII Phase 2, Phase 3,Phase 3
13 Antibodies Phase 2, Phase 3,Phase 3
14 Antineoplastic Agents, Alkylating Phase 3,Phase 2
15 Alkylating Agents Phase 3,Phase 2
16 Methylprednisolone acetate Phase 3
17 Antirheumatic Agents Phase 3,Phase 2
18 Antineoplastic Agents, Hormonal Phase 3,Phase 2
19 Prednisolone acetate Phase 3
20 Anti-Inflammatory Agents Phase 3,Phase 2
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3,Phase 2
22 Protective Agents Phase 3
23 Antiemetics Phase 3
24 Immunologic Factors Phase 3,Phase 2
25 Hormones Phase 3,Phase 2
26 Neuroprotective Agents Phase 3
27 Immunosuppressive Agents Phase 3,Phase 2
28 Peripheral Nervous System Agents Phase 3
29 Hormone Antagonists Phase 3,Phase 2
30 Gastrointestinal Agents Phase 3
31 glucocorticoids Phase 3,Phase 2
32 Autonomic Agents Phase 3
33
Bortezomib Approved, Investigational Phase 2 179324-69-7 387447 93860

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Study of Modified Recombinant Factor VIII (OBI-1) in Subjects With Acquired Hemophilia A Completed NCT01178294 Phase 2, Phase 3
2 Trial of Acquired Haemophilia With Steroid Combined With Cyclophosphamide Versus Steroid Combined With Rituximab Recruiting NCT03384277 Phase 3 Steroid;Rituximab;Cyclophosphamide
3 Trial of Rituximab Versus Oral Cyclophosphamide to Eradicate or Suppress Autoimmune Anti-Factor VIII Antibodies in Acquired Hemophilia A Terminated NCT00306670 Phase 2, Phase 3 Rituxan;prednisone
4 Study to Evaluate Rituximab and Bortezomib in Patients With Newly Diagnosed Acquired Hemophilia A Recruiting NCT03700229 Phase 2 Bortezomib;Rituximab
5 Post-Marketing Non-Interventional Safety Evaluation of Obizur in the Treatment of Bleeding Episodes for Patients With Acquired Hemophilia A Recruiting NCT02610127
6 Prospective, Non-interventional Study to Evaluate the Safety and Effectiveness of Obizur in Real-life Practice Recruiting NCT03199794
7 Expanded Access to B-Domain Deleted Recombinant Porcine Factor VIII (OBI-1) in the Treatment of Acquired Hemophilia A Due to Factor VIII Inhibitory Auto-antibodies No longer available NCT01968655

Search NIH Clinical Center for Acquired Hemophilia a

Genetic Tests for Acquired Hemophilia a

Genetic tests related to Acquired Hemophilia a:

# Genetic test Affiliating Genes
1 Acquired Factor Viii Deficiency Disease 29

Anatomical Context for Acquired Hemophilia a

MalaCards organs/tissues related to Acquired Hemophilia a:

41
Skin, Lung, Prostate, Heart, Neutrophil, Myeloid, Placenta

Publications for Acquired Hemophilia a

Articles related to Acquired Hemophilia a:

(show top 50) (show all 189)
# Title Authors Year
1
A Case of Acquired Hemophilia A: Usefulness of Various Methods for Judging Mixing Test Results for Monitoring the Effect of Immunosuppressive Therapy. ( 29739073 )
2018
2
The Development of Acute Systemic Multiple Thrombosis after Achieving Remission during Systemic Glucocorticoid Therapy for Acquired Hemophilia A. ( 29526954 )
2018
3
Can the plasmaderived factor VIII still play a role in the treatment of acquired hemophilia A at the time of new drugs? ( 29608457 )
2018
4
Successful management of concurrent acquired hemophilia A and a lupus anticoagulant in a pediatric hematopoietic stem cell transplant patient. ( 29330401 )
2018
5
Targeting Acquired Hemophilia A with Rheumatoid Arthritis by a Rituximab Shot: A Case Report and Review of the Literature. ( 29780157 )
2018
6
Acquired hemophilia A associated with autoimmune pancreatitis with serum IgG4 elevation. ( 29582334 )
2018
7
Newly Diagnosed Acquired Hemophilia A Manifesting as Massive Intracranial Hemorrhage Following a Neurosurgical Procedure. ( 29253693 )
2018
8
Acquired Hemophilia A in Aged People: A Systematic Review of Case Reports and Case Series. ( 30502847 )
2018
9
Management of Acquired Hemophilia A in Elderly Patients. ( 30538871 )
2018
10
Prevention and Management of Bleeding Episodes in Patients with Acquired Hemophilia A. ( 30542801 )
2018
11
Acquired Hemophilia A: Experience of a Tertiary Care Institute from North India. ( 30127565 )
2018
12
A case of acquired hemophilia A in an elderly female. ( 30181835 )
2018
13
Successful treatment of acquired hemophilia A associated with immune thrombocytopenia and joint hemarthrosis: A case report and literature review. ( 30235659 )
2018
14
Disseminated microinfarctions of the right kidney requiring nephrectomy: an unusual complication of acquired hemophilia A. ( 30280718 )
2018
15
Acquired hemophilia A developing cerebral infarction 36 days after the frequent administration of bypass hemostatic agents. ( 30283617 )
2018
16
Management of acquired hemophilia A: Review of current evidence. ( 30396835 )
2018
17
Acquired hemophilia A in solid cancer: Two case reports and review of the literature. ( 30510943 )
2018
18
Acquired factor VII deficiency causing severe bleeding disorder secondary to AL amyloidosis of the liver. ( 30344985 )
2018
19
Acquired Factor VII Deficiency in Association with Pyelonephritis. ( 30477072 )
2018
20
Acquired Hemophilia A After Hepatic Yttrium-90 Radioembolization: A Case Report. ( 28767473 )
2017
21
Autoimmune bullous disease and Hashimoto's disease complicated by acquired hemophilia A. ( 28381691 )
2017
22
Acquired Hemophilia A in an advanced age patient of hispanic origin: a case report. ( 28870236 )
2017
23
Treatment and complications in acquired hemophilia A. Experience from a single center. ( 28919213 )
2017
24
Clinical characteristics and outcomes of acquired hemophilia A: experience at a single center in Japan. ( 28299631 )
2017
25
Acquired hemophilia A: a review of recent data and new therapeutic options. ( 28441921 )
2017
26
Successful Management of Acquired Hemophilia A Associated with Bullous Pemphigoid: A Case Report and Review of the Literature. ( 28458935 )
2017
27
Disappearance of acquired hemophilia A after complete remission in a Multiple Myeloma patient. ( 28077343 )
2017
28
Acquired Hemophilia A in a Patient with Non-Small Cell Lung Carcinoma: A Rare Paraneoplastic Phenomenon. ( 28457068 )
2017
29
First report of real-time monitoring of coagulation function potential and IgG subtype of anti-FVIII autoantibodies in a child with acquired hemophilia A associated with streptococcal infection and amoxicillin. ( 28597369 )
2017
30
Successful management of recurrent bleeding with tocilizumab in an acquired hemophilia A patient with rheumatoid arthritis. ( 28781267 )
2017
31
Acquired hemophilia A following generalized pustular psoriasis of pregnancy. ( 28771773 )
2017
32
Acquired hemophilia A in a patient treated by Ginkgo-dipyridamolum. ( 28174634 )
2017
33
Acquired hemophilia A resolution in a hepatitis C virus/human immunodeficiency virus-coinfected patient with cure of hepatitis C by direct-acting antiviral agents. ( 28960371 )
2017
34
Hemorrhagic pericardial effusion as the debut of acquired hemophilia in a chronic lymphocytic leukemia patient: A case report, and a review of acquired hemophilia A-related hematological malignancies. ( 29381944 )
2017
35
Acquired hemophilia A: Updated review of evidence and treatment guidance. ( 28470674 )
2017
36
Initial Manifestation of Acquired Hemophilia A After a Routine Tooth Extraction. A Case Report and Literature Review. ( 28886353 )
2017
37
An extra X does not prevent acquired hemophilia - Pregnancy-associated acquired hemophilia A. ( 28262242 )
2017
38
Acquired hemophilia A manifesting as plasma transfusion-uncontrolled severe bleeding 2 weeks after chorioamnionitis-induced abortion. ( 28150393 )
2017
39
Two elderly patients with difficult-to-treat acquired hemophilia A. ( 27885231 )
2016
40
Immunoglobulin G4-related acquired hemophilia: A case report. ( 28105131 )
2016
41
Myelofibrosis and acquired hemophilia A: a case report. ( 27154067 )
2016
42
Acquired hemophilia A in a patient with hepatocellular carcinoma: a case report and literature review. ( 27666283 )
2016
43
Coexistence of acquired hemophilia A and epidermolysis bullosa acquisita: Two case reports and published work review. ( 27511892 )
2016
44
Remission of acquired hemophilia A following radiation therapy for esophageal cancer. ( 27169449 )
2016
45
Unusual Initial Manifestation of Acquired Hemophilia A: A Normal Activated Partial Thromboplastin Time, Intramuscular Hematoma and Cerebral Hemorrhage. ( 27853081 )
2016
46
Life-threatening hemorrhage from acquired hemophilia A as a presenting manifestation of prostate cancer. ( 27609734 )
2016
47
Bleeding due to acquired hemophilia A in acute pancreatitis: a case report. ( 26743559 )
2016
48
Acquired Hemophilia A May Be Associated with Ticagrelor Therapy in a 52-Year-Old Man After a Recent Percutaneous Transluminal Coronary Angioplasty. ( 27660505 )
2016
49
Acquired factor VII deficiency following FOLFOX in a patient with colorectal cancer who was also DPD deficient. ( 26770273 )
2016
50
Acquired hemophilia A that developed during the induction of hemodialysis: the use of double-filtration plasmapheresisa8c. ( 27545905 )
2016

Variations for Acquired Hemophilia a

Expression for Acquired Hemophilia a

Search GEO for disease gene expression data for Acquired Hemophilia a.

Pathways for Acquired Hemophilia a

GO Terms for Acquired Hemophilia a

Cellular components related to Acquired Hemophilia a according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.55 F11 F3 F5 F8 F9
2 endoplasmic reticulum-Golgi intermediate compartment membrane GO:0033116 9.37 F5 F8
3 platelet alpha granule lumen GO:0031093 9.32 F5 F8
4 COPII-coated ER to Golgi transport vesicle GO:0030134 9.26 F5 F8
5 endoplasmic reticulum lumen GO:0005788 9.13 F5 F8 F9
6 extracellular space GO:0005615 9.02 F11 F3 F5 F8 F9

Biological processes related to Acquired Hemophilia a according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ER to Golgi vesicle-mediated transport GO:0006888 9.43 F5 F8 F9
2 platelet degranulation GO:0002576 9.37 F5 F8
3 blood coagulation GO:0007596 9.35 F11 F3 F5 F8 F9
4 blood coagulation, intrinsic pathway GO:0007597 9.33 F11 F8 F9
5 COPII vesicle coating GO:0048208 9.32 F5 F8
6 hemostasis GO:0007599 9.02 F11 F3 F5 F8 F9

Molecular functions related to Acquired Hemophilia a according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.96 F5 F8
2 serine-type endopeptidase activity GO:0004252 8.8 F11 F3 F9

Sources for Acquired Hemophilia a

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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