MCID: ACQ008
MIFTS: 22

Acquired Hyperkeratosis

Categories: Skin diseases

Aliases & Classifications for Acquired Hyperkeratosis

MalaCards integrated aliases for Acquired Hyperkeratosis:

Name: Acquired Hyperkeratosis 12 15
Keratosis Blennorrhagica 71
Keratoderma - Acquired 12
Keratoderma, Acquired 12
Acquired Keratoderma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:13072
ICD9CM 34 701.1
NCIt 49 C34746
SNOMED-CT 67 400166009
UMLS 71 C0022581 C0022594

Summaries for Acquired Hyperkeratosis

MalaCards based summary : Acquired Hyperkeratosis, also known as keratosis blennorrhagica, is related to keratosis and netherton syndrome. An important gene associated with Acquired Hyperkeratosis is SMPD1 (Sphingomyelin Phosphodiesterase 1), and among its related pathways/superpathways are EGF/EGFR Signaling Pathway and UVA-Induced MAPK Signaling. Affiliated tissues include skin, and related phenotypes are integument and nervous system

Related Diseases for Acquired Hyperkeratosis

Diseases related to Acquired Hyperkeratosis via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 keratosis 9.9
2 netherton syndrome 9.7 KLK7 DSG1
3 hypotrichosis 9.4 DSG1 CTSV
4 skin disease 9.0 MAPK14 KLK7 DSG1

Symptoms & Phenotypes for Acquired Hyperkeratosis

MGI Mouse Phenotypes related to Acquired Hyperkeratosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 integument MP:0010771 9.26 CTSV DSG1 MAPK14 PXDN
2 nervous system MP:0003631 9.02 CTSV KLK7 MAPK14 PXDN SMPD1

Drugs & Therapeutics for Acquired Hyperkeratosis

Search Clinical Trials , NIH Clinical Center for Acquired Hyperkeratosis

Genetic Tests for Acquired Hyperkeratosis

Anatomical Context for Acquired Hyperkeratosis

MalaCards organs/tissues related to Acquired Hyperkeratosis:

40
Skin

Publications for Acquired Hyperkeratosis

Articles related to Acquired Hyperkeratosis:

(show all 27)
# Title Authors PMID Year
1
Topical Selenium Sulfide for the Treatment of Hyperkeratosis. 61
30203232 2018
2
Carcinoma of the stomach with hyperkeratosis palmaris et plantaris and acanthosis of the esophagus. 61
9517655 1998
3
Unusual acquired hyperkeratosis: a case report. 61
6628807 1983
4
[Keratosis blennorrhagica and circinate vulvitis as a manifestation of Reiter's disease in women]. 61
6449794 1980
5
Psoriasis and Reiter's syndrome. 61
11850911 1965
6
THE OCCURRENCE OF THE MUCOCUTANEOUS LESIONS OF REITER'S SYNDROME ("KERATOSIS BLENNORRHAGICA") IN A PATIENT WITH CLASSICAL RHEUMATOID ARTHRITIS. 61
14150748 1964
7
Reiter's syndrome complicated by universal keratosis blennorrhagica. 61
14481460 1961
8
Reiter's syndrome and keratosis blennorrhagica. 61
14445617 1960
9
Reiter's syndrome versus keratosis blennorrhagica sine blennorrhea. 61
13668736 1959
10
Keratosis blennorrhagica (Reiter's disease?) and its treatment. 61
13636450 1959
11
Keratosis blennorrhagica: report of 2 cases successfully treated with corticotropin (ACTH). 61
13352982 1955
12
Keratosis blennorrhagica or Reiter's syndrome? 61
13165995 1954
13
Keratosis blennorrhagica. 61
13007191 1953
14
Keratosis blennorrhagica successfully treated with corticotropin (ACTH); report of a case. 61
14927467 1952
15
Keratosis blennorrhagica. 61
14829065 1951
16
Case of keratosis blennorrhagica. 61
14789421 1950
17
Severe keratosis blennorrhagica complicating Reiter's disease. 61
15394920 1949
18
Reiter's disease with keratosis blennorrhagica. 61
18141021 1949
19
Response of keratosis blennorrhagica to penicillin. 61
18137675 1949
20
Keratosis blennorrhagica; report of a case treated with penicillin and hyperpyrexia. 61
18135298 1949
21
Keratosis blennorrhagica; response to streptomycin; report of a case. 61
18115012 1949
22
Keratosis Blennorrhagica. A Case Report with a Review of the Literature. 61
29014755 1948
23
Cutaneous manifestations of gonococcic infection; keratosis blennorrhagica treated with penicillin. 61
18912473 1948
24
Reiter's disease; a comparison with keratosis blennorrhagica and with psoriasis arthropathica. 61
20257236 1947
25
Penicillin in the treatment of keratosis blennorrhagica with polyarthritis. 61
20285224 1947
26
Etiologic considerations of keratosis blennorrhagica; report of a case in which penicillin was used. 61
20995034 1946
27
Keratosis blennorrhagica; its response to penicillin. 61
21023716 1946

Variations for Acquired Hyperkeratosis

Expression for Acquired Hyperkeratosis

Search GEO for disease gene expression data for Acquired Hyperkeratosis.

Pathways for Acquired Hyperkeratosis

Pathways related to Acquired Hyperkeratosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.54 PXDN MAPK14
2
Show member pathways
11.37 SMPD1 MAPK14
3 11.26 SMPD1 CTSV
4
Show member pathways
11.05 SMPD1 MAPK14
5 10.7 SMPD1 MAPK14

GO Terms for Acquired Hyperkeratosis

Cellular components related to Acquired Hyperkeratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 SMPD1 PXDN KLK7 CTSV
2 secretory granule GO:0030141 9.16 KLK7 CTSV
3 extracellular region GO:0005576 9.02 SMPD1 PXDN MAPK14 KLK7 CTSV
4 lysosomal lumen GO:0043202 8.96 SMPD1 CTSV

Biological processes related to Acquired Hyperkeratosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix disassembly GO:0022617 8.62 KLK7 CTSV

Sources for Acquired Hyperkeratosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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