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AIDS
MCID: ACQ007
MIFTS: 63

Acquired Immunodeficiency Syndrome (AIDS)

Categories: Immune diseases, Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acquired Immunodeficiency Syndrome

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MalaCards integrated aliases for Acquired Immunodeficiency Syndrome:

Name: Acquired Immunodeficiency Syndrome 12 3 44 15 73
Acquired Immune Deficiency Syndrome 12 76 3 15
Aids 12 48
Acquired Immune Deficiency 12

Classifications:

MalaCards categories:
Global: Infectious diseases
Anatomical: Immune diseases
See all MalaCards categories (disease lists)
ICD10: 33


External Ids:

Disease Ontology 12 DOID:635
ICD10 33 B20
MeSH 44 D000163
NCIt 50 C2851
SNOMED-CT 68 62479008
UMLS 73 C0001175
Sources

Summaries for Acquired Immunodeficiency Syndrome

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Disease Ontology : 12 A Human immunodeficiency virus infectious disease that results in reduction in the numbers of CD4-bearing helper T cells below 200 per ��L of blood or 14% of all lymphocytes thereby rendering the subject highly vulnerable to life-threatening infections and cancers, has material basis in Human immunodeficiency virus 1 or has material basis in Human immunodeficiency virus 2, which are transmitted by sexual contact, transmitted by transfer of blood, semen, vaginal fluid, pre-ejaculate, or breast milk, transmitted by congenital method, and transmitted by contaminated needles. Opportunistic infections are common in people with AIDS.

MalaCards based summary : Acquired Immunodeficiency Syndrome, also known as acquired immune deficiency syndrome, is related to human immunodeficiency virus type 1 and cytomegalovirus retinitis. An important gene associated with Acquired Immunodeficiency Syndrome is HCP5 (HLA Complex P5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Rilpivirine and Darunavir have been mentioned in the context of this disorder. Affiliated tissues include t cells, testes and bone, and related phenotypes are cellular and homeostasis/metabolism

CDC : 3 Help

Wikipedia : 76 Human immunodeficiency virus infection and acquired immune deficiency syndrome (HIV/AIDS) is a spectrum... more...

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Related Diseases for Acquired Immunodeficiency Syndrome

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Diseases related to Acquired Immunodeficiency Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1840)
# Related Disease Score Top Affiliating Genes
1 human immunodeficiency virus type 1 32.3 B2M CCR2 CCR5 CD38 CD4 IFNG
2 cytomegalovirus retinitis 31.1 CCR2 CCR5 CSF2 IFNG TNF
3 pneumocystosis 31.1 ALB CD4 TNF
4 meningitis 30.8 ALB IFNG IL10 IL6 TNF
5 cytomegalovirus infection 30.8 B2M IL6 TNF
6 toxoplasmosis 30.7 CCR5 IFNG IL10 IL6 TNF
7 uveitis 30.5 IFNG IL10 TNF
8 viral infectious disease 30.5 CCR5 CD4 IFNG IL10 IL2 IL6
9 cholangitis 30.5 ALB IL6 TNF
10 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 30.4 CCR5 CD4 IFNG IL10 IL2 ITIH4
11 aspergillosis 30.4 CSF2 IFNG IL10 TNF
12 cutaneous leishmaniasis 30.3 IFNG IL10 TNF
13 lymphadenitis 30.3 IFNG IL10 TNF
14 colitis 30.3 IFNG IL10 IL2 IL6 TNF
15 lymphoma, non-hodgkin, familial 30.2 B2M CD38 CSF2 IL2 MYC
16 arthritis 30.2 CSF2 IFNG IL10 IL6 TNF
17 meningoencephalitis 30.2 ALB B2M IL6
18 paracoccidioidomycosis 30.2 IFNG IL10 IL2 IL6 TNF
19 appendicitis 30.1 ALB IL10 IL6 TNF
20 hypersplenism 30.1 ALB CSF2 IFNG
21 mucocutaneous leishmaniasis 30.1 CCR5 IL10 TNF
22 visceral leishmaniasis 30.1 ALB IFNG IL10 IL2 TNF
23 aids dementia complex 30.1 B2M ITIH4 TNF
24 peritonitis 30.1 ALB B2M IL10 IL6 TNF
25 chagas disease 30.1 CCR5 IFNG IL10 IL2 IL6 TNF
26 angioimmunoblastic lymphadenopathy with dysproteinemia 30.1 IL6 TNF
27 osteomyelitis 30.0 IFNG IL10 IL6 TNF
28 chlamydia 30.0 IFNG IL10 IL6 TNF
29 leishmaniasis 30.0 CCR5 IFNG IL10 IL2 IL6 RN7SL1
30 smallpox 30.0 CSF2 IFNG IL2 TNF
31 hemophagocytic lymphohistiocytosis 30.0 B2M IFNG IL10 TNF
32 demyelinating disease 30.0 IFNG IL10 TNF
33 adult respiratory distress syndrome 30.0 IL10 IL6 TNF
34 pericarditis 30.0 IFNG IL6 TNF
35 rheumatic heart disease 30.0 IL10 IL6 TNF
36 peripheral nervous system disease 29.9 ALB IL6 TNF
37 lung disease 29.9 CSF2 IL10 IL6 TNF
38 trichosporonosis 29.9 CSF2 IFNG TNF
39 herpes zoster 29.9 HCP5 IFNG IL10 IL2
40 keratoconjunctivitis 29.9 IFNG IL2 TNF
41 skin disease 29.9 B2M IFNG IL10 TNF
42 tuberculous peritonitis 29.9 ALB IFNG TNF
43 arteries, anomalies of 29.8 ALB IL6 TNF
44 diabetes mellitus 29.8 ALB CCR5 IFNG IL2 IL6 TNF
45 echinococcosis 29.8 IFNG IL10 IL6 TNF
46 bronchiolitis 29.8 IFNG IL10 IL6 TNF
47 bronchiolitis obliterans 29.8 IFNG IL10 IL6 TNF
48 trypanosomiasis 29.8 ALB IFNG IL10 IL2 IL6 TNF
49 multiple sclerosis 29.8 CCR5 IFNG IL10 IL2 IL6 TNF
50 posterior uveitis 29.8 IFNG IL2 IL6 TNF

Graphical network of the top 20 diseases related to Acquired Immunodeficiency Syndrome:



Diseases related to Acquired Immunodeficiency Syndrome
Sources

Symptoms & Phenotypes for Acquired Immunodeficiency Syndrome

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MGI Mouse Phenotypes related to Acquired Immunodeficiency Syndrome:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.36 ALB B2M CCR2 CCR5 CD38 CD4
2 homeostasis/metabolism MP:0005376 10.28 ALB B2M CCR2 CCR5 CD38 CD4
3 hematopoietic system MP:0005397 10.27 B2M CCR2 CCR5 CD38 CD4 CSF2
4 cardiovascular system MP:0005385 10.26 B2M CCR2 CCR5 CSF2 F9 IFNG
5 digestive/alimentary MP:0005381 10.24 ALB B2M CCR2 CCR5 CD4 IFNG
6 endocrine/exocrine gland MP:0005379 10.22 ALB B2M CD38 CD4 CSF2 IFNG
7 immune system MP:0005387 10.22 B2M CCR2 CCR5 CD38 CD4 CSF2
8 liver/biliary system MP:0005370 10.1 ALB B2M CCR2 CCR5 F9 IFNG
9 mortality/aging MP:0010768 10.07 ALB B2M CCR2 CCR5 CD4 CSF2
10 integument MP:0010771 9.97 B2M CD4 CSF2 IFNG IL10 IL6
11 neoplasm MP:0002006 9.93 ALB B2M CCR2 CCR5 CSF2 IFNG
12 no phenotypic analysis MP:0003012 9.56 CCR2 CCR5 CD4 IFNG IL10 IL2
13 reproductive system MP:0005389 9.28 B2M CCR5 CSF2 IFNG IL10 IL2
Sources

Drugs & Therapeutics for Acquired Immunodeficiency Syndrome

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Drugs for Acquired Immunodeficiency Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1257)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Rilpivirine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 500287-72-9
2
Darunavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 206361-99-1, 635728-49-3 213039
3
Cobicistat Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1004316-88-4
4
Emtricitabine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 143491-57-0 60877
5
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 52485-79-7 40400 644073
6
Pentoxifylline Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 6493-05-6 4740
7
Ribavirin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 36791-04-5 37542
8
Lamivudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 134678-17-4 60825
9
Abacavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 136470-78-5 65140 441300
10
Stavudine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 3056-17-5 18283
11
Rifabutin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 72559-06-9 6323490
12
Ritonavir Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 155213-67-5 392622
13 Dolutegravir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1051375-16-6 54726191
14
Lopinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 192725-17-0 92727
15
Zidovudine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 30516-87-1 35370
16
Efavirenz Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 154598-52-4 64139
17
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 22916-47-8 4189
18
Isoniazid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 54-85-3 3767
19
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Not Applicable,Early Phase 1 564-25-0 54671203
20
Trimethoprim Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 738-70-5 5578
21
Sulfamethoxazole Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 723-46-6 5329
22
Maraviroc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 376348-65-1 3002977
23
Guaifenesin Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 93-14-1 3516
24
Methadone Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 76-99-3 4095
25
Artemether Approved Phase 4,Phase 3,Phase 1,Not Applicable 71963-77-4 119380 68911
26
Rifampicin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 13292-46-1 5458213 5381226
27
Nevirapine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 129618-40-2 4463
28
Lumefantrine Approved Phase 4,Phase 3,Phase 1,Not Applicable 82186-77-4 6437380
29
Didanosine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69655-05-6 50599
30
Nelfinavir Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 159989-64-7 64143
31
Candesartan cilexetil Approved Phase 4 145040-37-5 2540
32
Angiotensin II Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 11128-99-7, 68521-88-0, 4474-91-3 172198 65143
33
Lercanidipine Approved, Investigational Phase 4 100427-26-7 65866
34
Amprenavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 161814-49-9 65016
35
Mycophenolic acid Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 24280-93-1 446541
36 tannic acid Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 94-09-7, 1994-09-7 2337
38
Fenofibrate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 49562-28-9 3339
39
Pravastatin Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 81093-37-0 54687
40
Ezetimibe Approved Phase 4,Phase 1,Not Applicable 163222-33-1 150311
41
Peginterferon alfa-2a Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 198153-51-4 5360545
42
Pyrazinamide Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 98-96-4 1046
43
Ethambutol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 74-55-5 3279 14052
44
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 1397-89-3 5280965 14956
45
Calcium Carbonate Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 471-34-1
46
Alendronate Approved Phase 4,Phase 3,Phase 2 66376-36-1, 121268-17-5 2088
47
Entecavir Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 142217-69-4 153941
48
Desogestrel Approved Phase 4,Phase 2,Not Applicable 54024-22-5 40973
49
Ethinyl Estradiol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 57-63-6 5991
50
Estradiol Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-28-2 5757

Interventional clinical trials:

(show top 50) (show all 9308)
# Name Status NCT ID Phase Drugs
1 A Comparison of Virco®TYPE HIV-1 Testing Versus Expert Interpretation of Genotypic Results for Control of HIV-1 Replication Unknown status NCT00840762 Phase 4
2 Open Label, Pilot Study of Darunavir Boosted by Cobicistat in Combination With Rilpivirine to Treat HIV+ Naïve Subjects Unknown status NCT02404233 Phase 4 darunavir/cobicistat;rilpivirine
3 HIV Persistence and Viral Reservoirs Unknown status NCT01025427 Phase 4 Raltegravir, tenofovir/emtricitabine
4 Integrating Buprenorphine Into HIV Treatment Unknown status NCT00241930 Phase 4
5 Efficacy of PTX+IFN Alpha+ RBV on Hepatitis C Virus Coinfected HIV Patients Unknown status NCT02008214 Phase 4 Pentoxifylline;Placebo
6 Pilot Study With Isentress (Raltegravir) and Epzicom (Abacavir/Lamivudine) in Treatment Naive HIV-Infected Subjects Unknown status NCT00740064 Phase 4 Raltegravir and Abacavir/Lamivudine
7 Study on the Antiviral Therapy and Immune Reconstitution of Chinese HIV/AIDS Patients Unknown status NCT00872417 Phase 4 first line ARV (3TC+NVP+D4T or 3TC+NVP+AZT);second line ARV therapy (3TC+TDF+LPV/RTV)
8 Efficacy and Safety of Raltegravir (RAL) in Treatment-experienced HIV-1 Infected Adult Chinese Patients Unknown status NCT01201239 Phase 4 raltegravir
9 Buprenorphine and Integrated HIV Care Evaluation Unknown status NCT00124358 Phase 4 Buprenorphine
10 Raltegravir + Lamivudine/Abacavir in HIV/Tuberculosis Co-Infected Patients Unknown status NCT01059422 Phase 4 Raltegravir; Abacavir/Lamivudine
11 Comparing a Nucleoside-Analogue-Sparing Regimen and a Protease-Inhibitor-Sparing Regimen in HIV Infected Patients Unknown status NCT00135460 Phase 4 nucleoside analogue sparing HAART regimen
12 RAL+ATV/r in Comparison With TDF/FTC (or 3TC) +ATV/r in HIV Infected Patients Unknown status NCT01829802 Phase 4 Ritonavir boosted Atazanavir;Raltegravir;TDF/FTC (or 3TC)
13 Botswana Combination Prevention Project Unknown status NCT01965470 Phase 4
14 Impact of Starting a Dolutegravir-based Regimen on HIV-1 Proviral DNA Reservoir Of Treatment Naïve and Experienced Patients Unknown status NCT02370979 Phase 4
15 Immune Reconstitution as a Determinant of Adverse Effects to New Antiretroviral Therapy in Persons With Advanced HIV Infection Unknown status NCT00885664 Phase 4 Truvada (tenofovir/emitricitabine);Kaletra (lopinavir/ritonavir)
16 PI Vs. NNRTI Based Therapy for HIV Advanced Disease Unknown status NCT00162643 Phase 4 zidovudine+lamivudine+lopinavir/ritonavir;zidovudine + lamivudine + efavirenz
17 Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus Unknown status NCT00797030 Phase 4 cyclosporine and sodium carboximethycellulose;sodium carboximethycellulose
18 Diagnosis and Treatment of Co-infection With Human Immunodeficiency Virus /Latent Tuberculosis Infection (HIV/TBL) Unknown status NCT01875952 Phase 4 Isoniazid
19 Tenofovir/Emtricitabine With Doxycycline for Combination HIV and Syphilis Pre-exposure Prophylaxis in HIV-negative MSM Unknown status NCT02844634 Phase 4 Doxycycline 100mg PO daily x 12 months;Tenofovir/emtricitabine 200/300mg PO daily;Doxycycline 100mg PO daily x 6 months
20 Cotrimoxazole Prophylaxis Cessation Study Among Stabilized HIV-Infected Adult Patients on HAART in Entebbe, Uganda Unknown status NCT00674921 Phase 4 cotrimoxazole;Placebo
21 Maraviroc (Celsentri) With Raltegravir and Darunavir/Ritonavir for the Treatment of Triple Class Failure in Adult HIV-1 Infected Patients Unknown status NCT01013987 Phase 4 maraviroc;Raltegravir;Darunavir/ritonavir
22 Safety and Efficacy Study Comparing Raltegravir to a Protease Inhibitor in Treatment-naïve, HIV/Hepatitis C Drug Users Unknown status NCT01105611 Phase 4 Raltegravir;Atazanavir/Ritonavir
23 A Pilot Study of Triple NtRTI/NsRTI Therapy in Antiretroviral Naive HIV-1 Infected Patients Unknown status NCT00199121 Phase 4 Zidovudine (drug)
24 Lopinavir/Ritonavir or Efavirenz as First-line Antiretroviral Therapy Unknown status NCT01049685 Phase 4 First-line Antiretroviral Therapy
25 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
26 Drug Interaction Between Coartem® and Nevirapine, Efavirenz or Rifampicin in HIV Positive Ugandan Patients Unknown status NCT00620438 Phase 4 Lumefantrine-artemether and nevirapine;lumefantrine-artemether and efavirenz;Lumefantrine-artemether and rifampicin
27 Effect of Maraviroc (MCV) on the Immunological Recovery of HIV-1 Discordant Patients With CD4 Lymphocyte Counts Below 200 Cells/mm3 Unknown status NCT01235013 Phase 4 Maraviroc
28 Treatment With Nelfinavir or Efavirenz of HIV-Infected Patients Who Have Never Received Anti-HIV Drugs Unknown status NCT00005000 Phase 4 Nelfinavir mesylate;Efavirenz;Lamivudine;Keyhole-Limpet Hemocyanin;Stavudine;Zidovudine;Didanosine
29 Effect of a Non-tenofovir, Non-efavirenz-based HIV Regimen on Bone Density and Vitamin D Levels in African-American Patients With HIV Infection Unknown status NCT01343225 Phase 4 atripla;darunavir ritonavir raltegravir
30 Safety and Effectiveness of TRIZIVIR (Abacavir/Lamivudine/Zidovudine) With Efavirenz in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs Unknown status NCT00011895 Phase 4 Abacavir sulfate, Lamivudine and Zidovudine;Efavirenz
31 Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine Unknown status NCT00564057 Phase 4 candesartan;lercanidipine
32 Effectiveness and Safety of Epivir/Ziagen/Zerit (3TC/ABC/d4T) Versus Epivir/Ziagen/Sustiva (3TC/ABC/EFV) Versus Epivir/Ziagen/Agenerase/Norvir (3TC/ABC/APV/RTV) in HIV Patients Who Have Never Received Treatment Unknown status NCT00005017 Phase 4 Ritonavir;Abacavir sulfate;Amprenavir;Efavirenz;Lamivudine;Stavudine
33 Effects of Mycophenolate Mofetil (MMF) on Surrogate Markers for Cardiovascular Disease in HIV-1 Infected Patients Unknown status NCT00247494 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
34 PrEP Demonstration Project (PRELUDE Study) Unknown status NCT02206555 Phase 4 emtricitabine/tenofovir disoproxil fumarate
35 Does Rosuvastatin Delay Progression of Atherosclerosis in HIV Unknown status NCT01813357 Phase 4 Rosuvastatin
36 Once Daily 3TC, Efavirenz and ddI for HIV Infection Unknown status NCT00214435 Phase 4 once daily minimum 3-drug regimen of anti-retroviral medications
37 Safety and Immune Response to Adjuvanted A(H1N1)v Influenza Vaccine in HIV-1 Infected and Immunosuppressed Adult Patients Unknown status NCT01017172 Phase 4
38 Atazanavir/r + Lamivudine Dual Therapy Unknown status NCT01599364 Phase 4 Atazanavir, ritonavir, lamivudine
39 Simplification From Protease Inhibitors to Raltegravir Unknown status NCT00941083 Phase 4 Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy);Raltegravir (Use RAL as a simplification strategy)
40 Coadministration of Ezetimibe With Fenofibrate Versus Pravastatin Monotherapy for the Treatment of Hyperlipidaemia in HIV-infected Patients Unknown status NCT00843661 Phase 4 ezetimibe;fenofibrate;pravastatin
41 RAltegravir Switch STudy: Effects on Endothelial Recovery Unknown status NCT01453933 Phase 4 raltegravir
42 Equivalence of Boosted Atazanavir Based Regimens and Currently Effective HAART Regimens Unknown status NCT00940771 Phase 4 Boosted Atazanavir
43 Evaluation of Safety and Immunogenicity of a Human Papillomavirus (HPV) Vaccine in Human Immunodeficiency Virus (HIV) Infected Females Unknown status NCT01031069 Phase 4
44 Two Different Treatments 24 vs 48 Weeks Chronic Hepatitis C Genotypes 2 and/or 3 in co-Infected HIV-HCV Unknown status NCT00611819 Phase 4 Peg interferon + Ribavirin;Peg interferon + Ribavirin
45 Mycophenolate Mofetil in Antiretroviral Naïve Patients 2 (MAN2 Study) Unknown status NCT00120419 Phase 4 mycophenol mofetil (MMF, Cellcept®) 500 mg BID
46 Effects of 2 Initial Standard Antiretroviral Combinations Therapies on Lipid Metabolism Unknown status NCT00759070 Phase 4 Tenofovir + emtricitabine + efavirenz;Tenofovir + emtricitabine + lopinavir/ritonavir
47 Raltegravir and Atazanavir Replacing Current Suppressive Treatment Because of Side Effects in Current Treatment Unknown status NCT00751153 Phase 4 Raltegravir and Atazanavir
48 MEDICLAS Study (Metabolic Effects of Different Classes of AntiretroviralS) Unknown status NCT00122226 Phase 4 Lopinavir/ritonavir + zidovudine + lamivudine;Lopinavir/ritonavir + nevirapine
49 Immunogenicity of Influenza Vaccines in HIV-infected Persons in Thailand Unknown status NCT01538940 Phase 4
50 Evaluation of the Pharmacokinetics of Antituberculosis Drugs and Tuberculosis Treatment Outcomes Unknown status NCT01782950 Phase 4 Rifampicin, Isoniazid, Ethambutol, Pyrazinamide

Search NIH Clinical Center for Acquired Immunodeficiency Syndrome

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: acquired immunodeficiency syndrome

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Genetic Tests for Acquired Immunodeficiency Syndrome

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Sources

Anatomical Context for Acquired Immunodeficiency Syndrome

About this section

MalaCards organs/tissues related to Acquired Immunodeficiency Syndrome:

41
T Cells, Testes, Bone, Brain, Lung, Breast, Bone Marrow
Sources

Publications for Acquired Immunodeficiency Syndrome

About this section

Articles related to Acquired Immunodeficiency Syndrome:

(show top 50) (show all 2440)
# Title Authors Year
1
Correlation between Lymphocyte CD4 Count, Treatment Duration, Opportunistic Infection and Cognitive Function in Human Immunodeficiency Virus-Acquired Immunodeficiency Syndrome (HIV-AIDS) Patients. ( 29731931 )
2018
2
Disseminated toxoplasmosis in a patient with advanced acquired immunodeficiency syndrome. ( 29588907 )
2018
3
Self-care of elderly people after the diagnosis of acquired immunodeficiency syndrome. ( 29791625 )
2018
4
The Role of Faith-Based Organizations in the Education, Support, and Services for Persons Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. ( 29362058 )
2018
5
Association of Retinal Vascular Caliber and Age-Related Macular Degeneration in Patients With the Acquired Immunodeficiency Syndrome. ( 29435590 )
2018
6
Total dystrophic onychomycosis caused by<i>Talaromyces marneffei</i>in a patient with Acquired immunodeficiency syndrome on combined anti-retroviral therapy. ( 29251280 )
2018
7
Prevalence and variables associated with an abnormal ankle-brachial index among patients with human immunodeficiency virus/acquired immunodeficiency syndrome. ( 29649953 )
2018
8
Positive Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. ( 29362065 )
2018
9
Epidemiological situation of acquired immunodeficiency syndrome (AIDS)-related mortality in a municipality in northeastern Brazil. A retrospective cross-sectional study. ( 29340503 )
2018
10
Intestinal isosporiasis in patients with acquired immunodeficiency syndrome (AIDS). Pathologic diagnosis in small intestinal mucosal biopsies. ( 29566942 )
2018
11
Multiple Extradural Spinal Meningiomas in a Patient with Acquired Immunodeficiency Syndrome: Case Report and Literature Review. ( 29966786 )
2018
12
Fecal microbiota transplantation for severe complicated C. difficile colitis in a patient with acquired immunodeficiency syndrome. ( 29449093 )
2018
13
Lower likelihood of cardiac procedures after acute coronary syndrome in patients with human immunodeficiency virus/acquired immunodeficiency syndrome. ( 29419696 )
2018
14
Inpatient Outcomes After Elective Lumbar Spinal Fusion for Patients with Human Immunodeficiency Virus in the Absence of Acquired Immunodeficiency Syndrome. ( 29852306 )
2018
15
A Case of Jejunal Intussusception caused by Burkitt Lymphoma in an Acquired Immunodeficiency Syndrome Patient. ( 29637755 )
2018
16
Hemophagocytic lymphohistiocytosis (HLH) secondary to disseminated histoplasmosis in the setting of Acquired Immunodeficiency Syndrome (AIDS). ( 29657917 )
2018
17
Promoting Cardiovascular Health in Patients Living with Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome. ( 29362060 )
2018
18
Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome. ( 30101134 )
2018
19
Consecutive hypoglycemia attacks induced by co-trimoxazole followed by pentamidine in a patient with acquired immunodeficiency syndrome. ( 30170528 )
2018
20
Prevalence and factors associated with the use of traditional medicines among human immunodeficiency virus and acquired immunodeficiency syndrome patients in Sokoto, Nigeria. ( 30185681 )
2018
21
Cardiac complications in people living with human immunodeficiency virus/acquired immunodeficiency syndrome and their association with CD4+ T-cell count - A cross sectional study. ( 30187022 )
2018
22
Successful prevention of perinatal HIV transmission utilizing direct observation therapy in the setting of Acquired Immunodeficiency Syndrome (AIDS) and progressive multifocal leukoencephalopathy. ( 30245972 )
2018
23
Functional capacity and ventilatory efficiency are preserved in well-controlled people living with human immunodeficiency virus/acquired immunodeficiency syndrome. ( 30276193 )
2018
24
Blood pressure responses after resistance exercise session in women living with human immunodeficiency virus/acquired immunodeficiency syndrome. ( 30276194 )
2018
25
Adult T-cell leukemia/lymphoma and acquired immunodeficiency syndrome - CD4+ T-cell malignancy in CD4+ T-cell deficient status: A paradox. ( 30303147 )
2018
26
Prevalence of arterial hypertension and risk factors among people with acquired immunodeficiency syndrome. ( 30379250 )
2018
27
Endoscopic resection using argon plasma coagulation for treating esophageal mucosal bridge in a patient with acquired immunodeficiency syndrome. ( 30460905 )
2018
28
Restriction Fragment Length Polymorphism-based Genotyping of Toxoplasma gondii from Autopsy-Proven Cases of Acquired Immunodeficiency Syndrome-associated Cerebral Toxoplasmosis. ( 30532352 )
2018
29
Case Report: First Coinfection Report of Mixed Leishmania infantum/Leishmania major and Human Immunodeficiency Virus-Acquired Immune Deficiency Syndrome: Report of a Case of Disseminated Cutaneous Leishmaniasis in Iran. ( 29165208 )
2018
30
Histoplasmosis-induced ileal perforation in a patient with acquired immune deficiency syndrome: Case report. ( 30483583 )
2018
31
Esophagectomy in Patients with Human Immunodeficiency Virus and Acquired Immune Deficiency Syndrome: A Viable Option. ( 29747950 )
2018
32
Human immunodeficiency virus/acquired immune deficiency syndrome: A survey on the knowledge, attitude, and practice among medical professionals at a tertiary health-care institution in Uttarakhand, India. ( 29563671 )
2018
33
Risky sexual behaviour and human immunodeficiency virus (HIV) and acquired immune deficiency syndrome (AIDS) among healthcare workers. ( 29568646 )
2018
34
Alterations in the gut microbiota of patients with acquired immune deficiency syndrome. ( 29411528 )
2018
35
Social Representations of health care professionals on Acquired Immune Deficiency Syndrome. ( 30156680 )
2018
36
A retrospective analysis of seven patients with acquired immunodeficiency syndrome and pharyngeal and/or laryngeal Talaromyces marneffei infection. ( 28130931 )
2017
37
Point process methods in epidemiology: application to the analysis of human immunodeficiency virus/acquired immunodeficiency syndrome mortality in urban areas. ( 28555483 )
2017
38
The Complete Remission of Acquired Immunodeficiency Syndrome-associated Isolated Central Nervous System Lymphomatoid Granulomatosis: A Case Report and Review of the Literature. ( 28824078 )
2017
39
Imaging Findings of Common Opportunistic Infections and Malignant Tumors in Acquired Immunodeficiency Syndrome Patients. ( 29338829 )
2017
40
Double Morphology: Tertiary Syphilis and Acquired Immunodeficiency Syndrome-A Rare Association. ( 29225977 )
2017
41
Factors affecting antiretroviral treatment adherence among people living with human immunodeficiency virus/acquired immunodeficiency syndrome: A prospective study. ( 29416993 )
2017
42
Toxoplasmic Encephalitis in Patient with Acquired Immunodeficiency Syndrome. ( 28516077 )
2017
43
The End of Acquired Immunodeficiency Syndrome (AIDS) in Singapore - Are We There Yet? ( 29355281 )
2017
44
Advantages of Chinese medicine for patients with acquired immunodeficiency syndrome in rural central China. ( 28887810 )
2017
45
Cytomegalovirus Retinitis in Patients With Acquired Immunodeficiency Syndrome After Initiating Antiretroviral Therapy. ( 27984023 )
2017
46
Case Report: Disseminated Talaromyces (Penicillium) marneffei and Mycobacterium tuberculosis Coinfection in a Japanese Patient with Acquired Immunodeficiency Syndrome. ( 28719322 )
2017
47
Reproductive aspects and knowledge of family planning among women with Acquired Immunodeficiency Syndrome. ( 28562743 )
2017
48
Extensive brain masses and cavitary lung lesions associated with toxoplasmosis and acquired immunodeficiency syndrome. ( 28632476 )
2017
49
Uveitis as an initial manifestation of acquired immunodeficiency syndrome. ( 28201950 )
2017
50
Comparative analysis of cytomegalovirus retinitis and microvascular retinopathy in patients with acquired immunodeficiency syndrome. ( 28944199 )
2017
Sources

Variations for Acquired Immunodeficiency Syndrome

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Expression for Acquired Immunodeficiency Syndrome

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Search GEO for disease gene expression data for Acquired Immunodeficiency Syndrome.
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Pathways for Acquired Immunodeficiency Syndrome

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Pathways related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Super pathways Score Top Affiliating Genes
1
Innate Immune System 66
Show member pathways
 14.06 B2M CCR2 CCR5 CD4 CSF2 IFNG
2
PEDF Induced Signaling 64
Show member pathways
 13.72 CCR2 CCR5 CD4 CSF2 IFNG IL10
3
Akt Signaling 64
Show member pathways
 13.44 CCR2 CCR5 CD4 CSF2 IL10 IL2
4
PAK Pathway 64
Show member pathways
 13.34 CCR2 CCR5 CD4 CSF2 IL10 IL2
5
Cytokine Signaling in Immune system 66
Show member pathways
 13.33 B2M CCR2 CCR5 CD4 CSF2 IFNG
6
Human cytomegalovirus infection 37
Show member pathways
 13.09 B2M CCR5 CD4 CSF2 IL6 MYC
7
Allograft rejection 1 37
Show member pathways
 12.93 B2M CD4 IFNG IL10 IL2 IL6
8
Immune response NFAT in immune response 22
Show member pathways
 12.66 CD4 IFNG IL10 IL2 TNF
9
Th17 cell differentiation 37
Show member pathways
 12.64 CD4 IFNG IL10 IL2 IL6 MYC
10
Immune response IL-23 signaling pathway 22
Show member pathways
 12.62 CD4 IFNG IL10 IL2 IL6 MYC
11
NF-kappaB Signaling 4
12.58 B2M CCR2 CD38 IFNG IL10 IL2
12
Human T-cell leukemia virus 1 infection 37
12.48 CSF2 IL2 IL6 MYC TNF
13
Selenium Micronutrient Network 1
Show member pathways
 12.39 ALB IFNG IL2 IL6 TNF
14
JAK-STAT signaling pathway (KEGG) 37
Show member pathways
 12.37 CCR2 CCR5 CSF2 IFNG IL10 IL2
15
IL-17 Family Signaling Pathways 65
Show member pathways
 12.35 CSF2 IFNG IL6 TNF
16
T cell receptor signaling pathway 37
Show member pathways
 12.33 CCR5 CD4 CSF2 IFNG IL10 IL2
17
Epstein-Barr virus infection 37
12.32 B2M IL6 MYC TNF
18
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.32 IFNG IL10 IL2 IL6 MYC TNF
19
Toxoplasmosis 37
Show member pathways
 12.29 CCR5 IFNG IL10 TNF
20
Tuberculosis 37
12.27 IFNG IL10 IL6 TNF
21
C-type lectin receptor signaling pathway 37
Show member pathways
 12.24 IL10 IL2 IL6 TNF
22
Colorectal Cancer Metastasis 64
12.22 IFNG IL6 MYC TNF
23
Immune response IFN gamma signaling pathway 22
Show member pathways
 12.13 CD4 IFNG IL10 IL2 IL6 MYC
24
Microglia Activation During Neuroinflammation: Overview 65
Show member pathways
 12.09 CSF2 IFNG IL6 TNF
25
Th1 Differentiation Pathway 65
Show member pathways
 12.09 CD4 IFNG IL10 IL2 IL6 TNF
26
IL12-mediated signaling events 1
Show member pathways
 12.05 B2M CCR5 CD4 IFNG IL2
27
Interleukin-4 and 13 signaling 66
12.04 IL10 IL6 MYC TNF
28
Spinal Cord Injury 1
11.99 CCR2 IFNG IL2 IL6 MYC TNF
29
Hematopoietic cell lineage 37
11.96 CD38 CD4 CSF2 IL6 TNF
30
Amoebiasis 37
11.95 CSF2 IFNG IL10 IL6 TNF
31
Rheumatoid arthritis 37
11.92 CSF2 IFNG IL6 TNF
32
Jak-Stat Signaling Pathway (sino) 67
11.88 CCR2 CCR5 IFNG IL10 IL2 IL6
33
Glucocorticoid receptor regulatory network 1
11.87 CSF2 IFNG IL2 IL6
34
Salmonella infection (KEGG) 37
11.84 CSF2 IFNG IL6
35
Innate Lymphoid Cell Differentiation Pathways 65
11.84 CD4 IFNG IL10 IL2 TNF
36
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.83 CSF2 IFNG IL2 TNF
37
TGF-beta signaling pathway (KEGG) 37
11.82 IFNG MYC TNF
38
Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.82 CD38 CD4 CSF2 IFNG IL10 IL2
39
Pertussis 37
11.78 IL10 IL6 TNF
40
Lung fibrosis 1
11.73 CCR2 CSF2 IL6 TNF
41
Regulation of Telomerase 1
11.71 IFNG IL2 MYC
42
Downstream signaling in naive CD8+ T cells 1
Show member pathways
 11.71 B2M IFNG IL2 TNF
43
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.71 CSF2 IFNG IL2 IL6 TNF
44
Microglia Activation During Neuroinflammation: Microglia Polarization 65
11.7 CSF2 IFNG IL10 IL2 IL6 TNF
45
Photodynamic therapy-induced AP-1 survival signaling. 1
11.63 IFNG IL2 IL6 TNF
46
B Cell Development Pathways 65
11.61 CD38 CD4 IL10
47
Malaria 37
11.6 IFNG IL10 IL6 TNF
48
Th2 Differentiation Pathway 65
11.57 CD4 IFNG IL10 IL2
49
Aryl Hydrocarbon Receptor Pathway 1
11.56 IFNG IL2 TNF
50
MSP-RON Signaling 64
11.56 CCR2 IFNG TNF
Sources

GO Terms for Acquired Immunodeficiency Syndrome

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Cellular components related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.81 ALB B2M CSF2 F9 IFNG IL10
2 external side of plasma membrane GO:0009897 9.65 B2M CCR2 CCR5 CD4 TNF
3 extracellular region GO:0005576 9.65 ALB B2M CSF2 F9 IFNG IL10
4 endoplasmic reticulum lumen GO:0005788 9.02 ALB B2M CD4 F9 IL6

Biological processes related to Acquired Immunodeficiency Syndrome according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.99 CCR2 CCR5 IL10 IL6 TNF
2 positive regulation of protein phosphorylation GO:0001934 9.91 CD4 IFNG IL2 TNF
3 regulation of signaling receptor activity GO:0010469 9.91 CSF2 IFNG IL10 IL2 IL6 TNF
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.88 CCR2 CCR5 CD38 IL2
5 positive regulation of inflammatory response GO:0050729 9.83 CCR2 IL2 TNF
6 response to glucocorticoid GO:0051384 9.82 IL10 IL6 TNF
7 positive regulation of T cell proliferation GO:0042102 9.8 CD4 IL2 IL6
8 MAPK cascade GO:0000165 9.8 CCR5 CSF2 IL2 MYC TNF
9 positive regulation of smooth muscle cell proliferation GO:0048661 9.79 IL6 MYC TNF
10 positive regulation of interferon-gamma production GO:0032729 9.73 CCR2 IL2 TNF
11 negative regulation of bone resorption GO:0045779 9.67 CD38 IL6
12 positive regulation of immunoglobulin secretion GO:0051024 9.67 IL2 IL6
13 positive regulation of podosome assembly GO:0071803 9.66 CSF2 TNF
14 response to molecule of bacterial origin GO:0002237 9.66 B2M IL10
15 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097011 9.65 CD4 CSF2
16 negative regulation of lipid storage GO:0010888 9.65 IL6 TNF
17 cellular response to lipopolysaccharide GO:0071222 9.65 CCR5 CSF2 IL10 IL6 TNF
18 immune response GO:0006955 9.65 B2M CCR2 CCR5 CD4 CSF2 IFNG
19 endothelial cell apoptotic process GO:0072577 9.64 IL10 TNF
20 fusion of virus membrane with host plasma membrane GO:0019064 9.62 CCR5 CD4
21 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.62 CSF2 IFNG IL2 IL6
22 negative regulation of cytokine secretion involved in immune response GO:0002740 9.61 IL10 TNF
23 positive regulation of neuroinflammatory response GO:0150078 9.6 IL6 TNF
24 positive regulation of interleukin-23 production GO:0032747 9.58 CSF2 IFNG
25 entry into host cell GO:0030260 9.55 CCR5 CD4
26 positive regulation of glial cell proliferation GO:0060252 9.54 IL6 MYC TNF
27 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.51 IFNG TNF
28 receptor biosynthetic process GO:0032800 9.49 IL10 TNF
29 regulation of vascular endothelial growth factor production GO:0010574 9.48 CCR2 IL6
30 positive regulation of vitamin D biosynthetic process