MCID: ACQ043
MIFTS: 28

Acquired Lipodystrophy

Categories: Endocrine diseases, Immune diseases, Rare diseases, Skin diseases

Aliases & Classifications for Acquired Lipodystrophy

MalaCards integrated aliases for Acquired Lipodystrophy:

Name: Acquired Lipodystrophy 59

Classifications:



External Ids:

ICD10 via Orphanet 34 E88.1
UMLS via Orphanet 73 C0877192
Orphanet 59 ORPHA98307

Summaries for Acquired Lipodystrophy

MalaCards based summary : Acquired Lipodystrophy is related to acquired generalized lipodystrophy and congenital generalized lipodystrophy. An important gene associated with Acquired Lipodystrophy is LMNB2 (Lamin B2), and among its related pathways/superpathways are Adipogenesis and Sterol Regulatory Element-Binding Proteins (SREBP) signalling. The drugs Pioglitazone and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include skin, adipocyte and liver, and related phenotypes are homeostasis/metabolism and adipose tissue

Related Diseases for Acquired Lipodystrophy

Diseases in the Primary Lipodystrophy family:

Localized Lipodystrophy Acquired Lipodystrophy

Diseases related to Acquired Lipodystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 acquired generalized lipodystrophy 31.7 LMNB2 CAV1 BSCL2
2 congenital generalized lipodystrophy 29.3 CAV1 BSCL2
3 lipodystrophy, partial, acquired 12.2
4 panniculitis 10.1
5 hypertriglyceridemia, familial 10.1
6 mandibular hypoplasia, deafness, progeroid features, and lipodystrophy syndrome 10.1
7 acanthosis nigricans 10.0
8 autoimmune disease 10.0
9 familial partial lipodystrophy 10.0
10 dermatomyositis 10.0
11 polyneuropathy 10.0
12 renal cell carcinoma, nonpapillary 9.8
13 lipodystrophy, familial partial, type 2 9.8
14 myositis 9.8
15 dowling-degos disease 1 9.8
16 werner syndrome 9.8
17 lipodystrophy, familial partial, type 3 9.8
18 lipodystrophy, congenital generalized, type 1 9.8
19 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 9.8
20 fatty liver disease, nonalcoholic 1 9.8
21 exanthem 9.8
22 pancytopenia 9.8
23 childhood type dermatomyositis 9.8
24 calcinosis 9.8
25 autoimmune hepatitis 9.8
26 membranoproliferative glomerulonephritis 9.8
27 glomerulonephritis 9.8
28 lipid metabolism disorder 9.8
29 craniopharyngioma 9.8
30 demyelinating polyneuropathy 9.8
31 hemolytic anemia 9.8
32 juvenile rheumatoid arthritis 9.8
33 diabetes mellitus 9.8
34 chronic inflammatory demyelinating polyneuropathy 9.8
35 premature aging 9.8
36 berardinelli-seip congenital lipodystrophy 9.8 CAV1 BSCL2
37 complete generalized lipodystrophy 9.7 CAV1 BSCL2
38 lipodystrophy, congenital generalized, type 3 9.7 CAV1 BSCL2
39 overnutrition 9.5 SREBF1 FGF21
40 lipodystrophy, congenital generalized, type 4 9.4 CAV1 BSCL2

Graphical network of the top 20 diseases related to Acquired Lipodystrophy:



Diseases related to Acquired Lipodystrophy

Symptoms & Phenotypes for Acquired Lipodystrophy

MGI Mouse Phenotypes related to Acquired Lipodystrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.35 BSCL2 CAV1 FGF21 LMNB2 SREBF1
2 adipose tissue MP:0005375 9.33 BSCL2 CAV1 FGF21
3 liver/biliary system MP:0005370 8.92 BSCL2 CAV1 FGF21 SREBF1

Drugs & Therapeutics for Acquired Lipodystrophy

Drugs for Acquired Lipodystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pioglitazone Approved, Investigational 111025-46-8 4829
2
Cyclophosphamide Approved, Investigational 50-18-0, 6055-19-2 2907
3
2,4-thiazolidinedione Investigational 2295-31-0
4 Hypoglycemic Agents
5 Alkylating Agents
6 Immunologic Factors
7 Immunosuppressive Agents
8 Antirheumatic Agents
9 Antineoplastic Agents, Alkylating

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Human Immunodeficiency Virus Acquired Lipodystrophy (HAL) Classification, Measurement, & Fat Response to a Thiazolidinedione (TZD) Challenge in Differing Adult Phenotypic Presentations Unknown status NCT01023620 Pioglitazone
2 Lipodystrophy Connect Patient Registry Completed NCT02577952
3 Cyclophosphamide in the Treatment of Panniculitis Associated Acquired Lipodystrophy Syndrome With Type 1 Diabetes Recruiting NCT03936829 Cyclophosphamide

Search NIH Clinical Center for Acquired Lipodystrophy

Genetic Tests for Acquired Lipodystrophy

Anatomical Context for Acquired Lipodystrophy

MalaCards organs/tissues related to Acquired Lipodystrophy:

41
Skin, Adipocyte, Liver

Publications for Acquired Lipodystrophy

Articles related to Acquired Lipodystrophy:

(show all 44)
# Title Authors PMID Year
1
Acquired Lipodystrophy Associated With Nivolumab in a Patient With Advanced Renal Cell Carcinoma. 38
30779841 2019
2
Current Diagnosis and Treatment, and Clinical Challenges in the Management of Lipodystrophy Syndromes in Children and Youth 38
31434462 2019
3
Multiple sites acquired lipodystrophy in two siblings: a rare adverse effect of intramuscular triamcinolone. 38
31243027 2019
4
Acquired partial lipodystrophy with metabolic disease in children following hematopoietic stem cell transplantation: a report of two cases and a review of the literature. 38
31075084 2019
5
A novel paraneoplastic syndrome with acquired lipodystrophy and chronic inflammatory demyelinating polyneuropathy in an adolescent male with craniopharyngioma. 38
29455190 2018
6
Potential association of LMNA-associated generalized lipodystrophy with juvenile dermatomyositis. 38
29610677 2018
7
Barraquer-Simons Syndrome. 38
27650233 2016
8
Serum concentrations of fibroblast growth factor 21 are elevated in patients with congenital or acquired lipodystrophy. 38
27179139 2016
9
Barraquer-Simons syndrome: a rare form of acquired lipodystrophy. 38
26987365 2016
10
Lipodystrophies: adipose tissue disorders with severe metabolic implications. 38
25833179 2015
11
Paradoxical adipose hyperplasia secondary to cryolipolysis: An underreported entity? 38
26096832 2015
12
Metreleptin and generalized lipodystrophy and evolving therapeutic perspectives. 38
26063386 2015
13
Leptin in congenital and HIV-associated lipodystrophy. 38
25267014 2015
14
Effects of leptin replacement therapy on pancreatic β-cell function in patients with lipodystrophy. 38
24496806 2014
15
A role for adipocyte-derived lipopolysaccharide-binding protein in inflammation- and obesity-associated adipose tissue dysfunction. 38
23963324 2013
16
The liver diseases of lipodystrophy: the long-term effect of leptin treatment. 38
23439261 2013
17
Leptin as a modulator of neuroendocrine function in humans. 38
22665330 2012
18
Clinical effects of long-term metreleptin treatment in patients with lipodystrophy. 38
22068254 2011
19
Clinical review#: Lipodystrophies: genetic and acquired body fat disorders. 38
21865368 2011
20
Ethanol impairs differentiation of human adipocyte stromal cells in culture. 38
21599713 2011
21
Cardiomyopathy in congenital and acquired generalized lipodystrophy: a clinical assessment. 38
20616664 2010
22
Clinical classification and treatment of congenital and acquired lipodystrophy. 38
20061300 2010
23
HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy? 38
20074077 2010
24
Human lipodystrophies: genetic and acquired diseases of adipose tissue. 38
20551664 2010
25
Acquired generalized lipodystrophy associated with autoimmune hepatitis and low serum C4 level. 38
21274335 2010
26
Leptin in humans: lessons from translational research. 38
19176740 2009
27
Complement abnormalities in acquired lipodystrophy revisited. 38
18854390 2009
28
Predictors of acquired lipodystrophy in juvenile-onset dermatomyositis and a gradient of severity. 38
18344805 2008
29
Adipose tissue distribution and risk of metabolic disease: does thiazolidinedione-induced adipose tissue redistribution provide a clue to the answer? 38
17393135 2007
30
Childhood acquired lipodystrophy: a retrospective study. 38
17097389 2006
31
Role of CD95-mediated adipocyte loss in autoimmune lipodystrophy. 38
16368755 2006
32
Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus. 38
15592481 2004
33
The physiology of cellular liporegulation. 38
12471167 2003
34
[Diabetes and genetic and acquired lipodystrophy syndrome]. 38
12868305 2003
35
Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus. 38
12079864 2002
36
The molecular basis of genetic lipodystrophies. 38
12074822 2002
37
[Lipodystrophies]. 38
12015640 2002
38
Lipodystrophy. 38
11236228 2001
39
[Nonprogressive, late-onset atrophy of the cheek]. 38
11310188 2000
40
Dysregulation of insulin-like growth factors in a case of generalized acquired lipoatrophic diabetes mellitus (Lawrence Syndrome) connected with autoantibodies against adipocyte membranes. 38
9516065 1998
41
Insulin resistance in total lipodystrophy: evidence for a pre-receptor defect in insulin action. 38
3884963 1985
42
Gowers local panatrophy. 38
6530367 1984
43
The effect of diet on thermogenesis in acquired lipodystrophy. 38
481216 1979
44
[Extensive, disseminated acquired lipodystrophy]. 38
4770695 1973

Variations for Acquired Lipodystrophy

Expression for Acquired Lipodystrophy

Search GEO for disease gene expression data for Acquired Lipodystrophy.

Pathways for Acquired Lipodystrophy

Pathways related to Acquired Lipodystrophy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.08 SREBF1 BSCL2
2 10.49 SREBF1 FGF21

GO Terms for Acquired Lipodystrophy

Cellular components related to Acquired Lipodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nuclear envelope GO:0005635 8.96 SREBF1 LMNB2
2 endoplasmic reticulum membrane GO:0005789 8.8 SREBF1 CAV1 BSCL2

Biological processes related to Acquired Lipodystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fat cell differentiation GO:0045444 9.32 SREBF1 BSCL2
2 response to progesterone GO:0032570 9.26 SREBF1 CAV1
3 lipid storage GO:0019915 9.16 CAV1 BSCL2
4 positive regulation of catalytic activity GO:0043085 9.07 CAV1
5 regulation of fatty acid metabolic process GO:0019217 8.96 SREBF1 CAV1
6 positive regulation of cold-induced thermogenesis GO:0120162 8.8 FGF21 CAV1 BSCL2

Sources for Acquired Lipodystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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