MCID: ACQ009
MIFTS: 33

Acquired Metabolic Disease

Categories: Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease 12 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0060158

Summaries for Acquired Metabolic Disease

Disease Ontology : 12 A disease of metabolism that has material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to hyperuricemia and hyperprolactinemia. An important gene associated with Acquired Metabolic Disease is INS (Insulin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Developmental Biology. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder Metabolic Disease Due to Other Fatty Acid Oxidation Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 hyperuricemia 33.1 REN INS CRP
2 hyperprolactinemia 11.1
3 mineral metabolism disease 11.1
4 metabolic acidosis 11.1
5 amyloidosis 11.1
6 lipodystrophy, familial partial, type 1 11.1 PPARG LEP INS
7 abdominal obesity-metabolic syndrome quantitative trait locus 2 11.1 SLC2A4 LEP INS
8 lipodystrophy, congenital generalized, type 1 11.1 LEP INS ADIPOQ
9 obesity-hypoventilation syndrome 11.1 LEP IL6 ADIPOQ
10 complete generalized lipodystrophy 11.1 PPARG LEP INS
11 fatty liver disease, nonalcoholic 1 11.1 LEP INS ADIPOQ
12 loeffler syndrome 11.1 ALB ACE
13 microvascular complications of diabetes 3 11.1 INS ALB ACE
14 hypertensive retinopathy 11.1 REN ADIPOQ ACE
15 hypoaldosteronism 11.1 REN ACE
16 malignant otitis externa 11.1 INS CRP
17 orthostatic proteinuria 11.1 REN ALB ACE
18 nontuberculous mycobacterial lung disease 11.1 TNF LEP ADIPOQ
19 acquired generalized lipodystrophy 11.1 PPARG LEP INS ADIPOQ
20 fetal macrosomia 11.1 LEP INS IGF1
21 familial partial lipodystrophy 11.1 PPARG LEP INS
22 mixed cell adenoma 11.1 IRS1 IGF1
23 autoimmune myocarditis 11.1 TNF PPARG IL6
24 anuria 11.1 REN ALB ACE
25 inherited metabolic disorder 11.1 LEP INS CRP ADIPOQ
26 idiopathic edema 11.1 PPARG INS ADIPOQ ACE
27 acute insulin response 11.1 INS GCG CRP
28 acute cystitis 11.1 IL6 CRP ALB
29 sleep disorder 11.1 LEP INS IL6 CRP
30 tuberculous peritonitis 11.1 TNF CRP ALB
31 acute pyelonephritis 11.1 IL6 CRP ALB
32 pyelitis 11.0 REN IL6 CRP
33 hepatorenal syndrome 11.0 REN ALB ACE
34 intermediate coronary syndrome 11.0 IL6 CRP ACE
35 anovulation 11.0 LEP INS IGF1 CRP
36 systolic heart failure 11.0 IL6 CRP ACE
37 renal hypertension 11.0 REN ALB ACE
38 central nervous system vasculitis 11.0 TNF IL6 CRP
39 posterior urethral valves 11.0 TNF IL6 ACE
40 louse-borne relapsing fever 11.0 TNF IL6 CRP
41 angina pectoris 11.0 IL6 CRP ACE
42 paraphimosis 11.0 SLC5A4 SLC5A2 DPP4
43 intermittent claudication 11.0 IL6 CRP ALB ACE
44 mycoplasma pneumoniae pneumonia 11.0 TNF IL6 CRP
45 coronary stenosis 11.0 IL6 CRP ALB ACE
46 interstitial nephritis 11.0 REN CRP ALB ACE
47 balanoposthitis 11.0 SLC5A4 SLC5A2 DPP4
48 severe pre-eclampsia 11.0 LEP ALB ADIPOQ
49 scorpion envenomation 11.0 TNF IL6
50 peripheral artery disease 11.0 IL6 CRP ACE

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:



Diseases related to Acquired Metabolic Disease

Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ACE ADIPOQ ALB CRP DPP4 GHRL
2 cardiovascular system MP:0005385 10.35 ACE ADIPOQ CRP IGF1 IL6 INS
3 growth/size/body region MP:0005378 10.35 ACE ADIPOQ DPP4 IAPP IGF1 IL6
4 endocrine/exocrine gland MP:0005379 10.34 ACE ADIPOQ ALB DPP4 GHRL IGF1
5 adipose tissue MP:0005375 10.33 ACE ADIPOQ GHRL IGF1 IL6 INS
6 immune system MP:0005387 10.28 ACE ADIPOQ CRP IAPP IGF1 IL6
7 cellular MP:0005384 10.26 ADIPOQ ALB IGF1 IL6 INS IRS1
8 hematopoietic system MP:0005397 10.23 ACE ADIPOQ IAPP IGF1 IL6 INS
9 mortality/aging MP:0010768 10.13 ACE ADIPOQ ALB IGF1 IL6 INS
10 digestive/alimentary MP:0005381 10.11 ALB GHRL IL6 INS LEP SLC2A4
11 liver/biliary system MP:0005370 10.07 ACE ADIPOQ ALB IL6 INS IRS1
12 muscle MP:0005369 10 ADIPOQ ALB IGF1 IL6 INS IRS1
13 neoplasm MP:0002006 9.76 ACE ADIPOQ ALB IGF1 IL6 LEP
14 renal/urinary system MP:0005367 9.65 ACE ADIPOQ ALB IGF1 IL6 INS
15 skeleton MP:0005390 9.36 ADIPOQ IAPP IGF1 IL6 INS IRS1

Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

Genetic Tests for Acquired Metabolic Disease

Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

41
Liver

Publications for Acquired Metabolic Disease

Articles related to Acquired Metabolic Disease:

# Title Authors PMID Year
1
Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates. 38
30745819 2019
2
Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China. 38
25688884 2015
3
[Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. 38
17452309 2007

Variations for Acquired Metabolic Disease

Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 TNF PPARG LEP IRS1 INS IL6
2
Show member pathways
13.44 TNF SLC2A4 PPARG LEP IRS1 INS
3
Show member pathways
13 REN IRS1 INS IL6 IGF1 ACE
4
Show member pathways
12.7 TNF SLC2A4 LEP IRS1 INS IL6
5 12.4 SLC5A2 SLC2A4 PPARG IRS1 INS GCG
6
Show member pathways
12.29 TNF INS IL6 CRP ALB
8
Show member pathways
12.21 SLC2A4 PPARG LEP IRS1 INS IGF1
9
Show member pathways
12.18 TNF IL6 IGF1 ACE
10
Show member pathways
12.14 SLC2A4 LEP IRS1 INS
11
Show member pathways
12.09 PPARG IRS1 INS IGF1 ADIPOQ
12
Show member pathways
12.03 SLC2A4 IRS1 INS IL6 IGF1
13
Show member pathways
12.02 REN LEP INS IGF1 GHRL GCG
14 12 INS IL6 IGF1 ALB
15
Show member pathways
11.87 TNF SLC2A4 IRS1 INS IL6
16
Show member pathways
11.78 TNF SLC2A4 IRS1 INS ADIPOQ
17 11.73 TNF SLC2A4 PPARG LEP IRS1 INS
18 11.68 TNF PPARG IL6 IGF1
19 11.61 TNF IL6 IGF1
20 11.56 TNF SLC2A4 LEP IRS1 ADIPOQ
21
Show member pathways
11.55 LEP GCG DPP4
22 11.51 SLC2A4 LEP IRS1
23 11.47 LEP IRS1 INS
24 11.45 INS IL6 IGF1
25 11.41 TNF PTH IL6 IGF1
26 11.33 IRS1 INS IGF1
27 11.14 PPARG LEP ADIPOQ
28 10.99 TNF IL6 CRP
29 10.51 TNF SLC2A4 PPARG LEP IRS1 IL6

GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TNF REN PTH LEP INS IL6
2 endoplasmic reticulum lumen GO:0005788 9.55 INS IL6 GHRL GCG ALB
3 extracellular space GO:0005615 9.47 TNF REN PTH LEP INS IL6

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.95 INS IL6 IGF1 IAPP ALB
2 response to ethanol GO:0045471 9.87 SLC2A4 PTH LEP ADIPOQ
3 cellular response to insulin stimulus GO:0032869 9.86 SLC2A4 PPARG IRS1 ADIPOQ
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 IL6 IGF1 ADIPOQ
5 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 TNF IL6 GCG
6 response to nutrient GO:0007584 9.85 PPARG LEP ADIPOQ
7 positive regulation of protein kinase B signaling GO:0051897 9.85 TNF LEP IRS1 INS IAPP
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 LEP IL6 IGF1
9 response to glucocorticoid GO:0051384 9.82 TNF IL6 ADIPOQ
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.81 TNF LEP INS IGF1
11 positive regulation of protein kinase activity GO:0045860 9.8 TNF GCG ADIPOQ
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 TNF IL6 IGF1
13 regulation of insulin secretion GO:0050796 9.8 TNF LEP GCG DPP4
14 hormone-mediated signaling pathway GO:0009755 9.79 REN PPARG GHRL
15 negative regulation of fat cell differentiation GO:0045599 9.78 TNF IL6 ADIPOQ
16 regulation of blood pressure GO:0008217 9.78 REN PPARG LEP ACE
17 positive regulation of MAPK cascade GO:0043410 9.77 LEP INS IL6 IGF1 IAPP
18 acute-phase response GO:0006953 9.76 INS IL6 CRP
19 glucose metabolic process GO:0006006 9.72 TNF LEP INS GHRL ADIPOQ
20 glucose transmembrane transport GO:1904659 9.71 SLC5A4 SLC5A2 SLC2A4
21 response to nutrient levels GO:0031667 9.71 PTH LEP GHRL ADIPOQ
22 positive regulation of insulin receptor signaling pathway GO:0046628 9.7 LEP IRS1 INS
23 regulation of protein secretion GO:0050708 9.68 TNF INS
24 negative regulation of bone resorption GO:0045779 9.68 IL6 IAPP
25 angiotensin maturation GO:0002003 9.67 REN ACE
26 positive regulation of protein kinase A signaling GO:0010739 9.66 IAPP ADIPOQ
27 negative regulation of blood vessel diameter GO:0097756 9.66 INS CRP
28 adult feeding behavior GO:0008343 9.65 LEP GHRL
29 neutrophil mediated immunity GO:0002446 9.64 IL6 ACE
30 negative regulation of acute inflammatory response GO:0002674 9.63 PPARG INS
31 glucose homeostasis GO:0042593 9.63 SLC2A4 PPARG LEP IRS1 INS ADIPOQ
32 positive regulation of neuroinflammatory response GO:0150078 9.62 TNF IL6
33 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.61 PPARG CRP ADIPOQ
34 bone mineralization involved in bone maturation GO:0035630 9.6 LEP IGF1
35 positive regulation of glycogen biosynthetic process GO:0045725 9.56 PTH IRS1 INS IGF1
36 negative regulation of lipid storage GO:0010888 9.26 TNF LEP IL6 CRP
37 positive regulation of glucose import GO:0046326 9.02 PTH IRS1 INS IGF1 ADIPOQ
38 negative regulation of apoptotic process GO:0043066 10.07 LEP IL6 IGF1 GHRL GCG ALB
39 positive regulation of cell proliferation GO:0008284 10.05 LEP IRS1 INS IL6 IGF1 DPP4
40 positive regulation of gene expression GO:0010628 10.04 TNF INS IL6 IGF1 CRP

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.81 TNF PPARG INS IAPP GCG DPP4
2 signaling receptor binding GO:0005102 9.73 REN LEP IAPP GCG DPP4 ADIPOQ
3 drug binding GO:0008144 9.58 PPARG ALB ACE
4 insulin receptor binding GO:0005158 9.5 IRS1 INS IGF1
5 peptide hormone receptor binding GO:0051428 9.43 PTH LEP
6 glucose:sodium symporter activity GO:0005412 9.37 SLC5A4 SLC5A2
7 insulin-like growth factor receptor binding GO:0005159 9.26 REN IRS1 INS IGF1
8 hormone activity GO:0005179 9.23 PTH LEP INS IGF1 IAPP GHRL

Sources for Acquired Metabolic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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