MCID: ACQ009
MIFTS: 34

Acquired Metabolic Disease

Categories: Metabolic diseases

Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060158

Summaries for Acquired Metabolic Disease

Disease Ontology : 12 A disease of metabolism that has _material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to hyperuricemia and hyperprolactinemia. An important gene associated with Acquired Metabolic Disease is INS (Insulin), and among its related pathways/superpathways are Metabolism of proteins and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Affiliated tissues include kidney, liver and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 hyperuricemia 32.1 CRP INS REN
2 hyperprolactinemia 10.9
3 mineral metabolism disease 10.9
4 metabolic acidosis 10.9
5 amyloidosis 10.9
6 malignant otitis externa 10.5 CRP INS
7 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.5 IGF1 INS
8 severe nonproliferative diabetic retinopathy 10.5 ALB INS
9 idiopathic recurrent pericarditis 10.5 ADIPOQ LEP
10 scleredema adultorum 10.5 INS PTH
11 generalized atherosclerosis 10.5 ACE CRP
12 benign essential hypertension 10.5 ALB REN
13 hyperinsulinemic hypoglycemia, familial, 7 10.5 GCG INS
14 kidney papillary necrosis 10.5 ALB REN
15 type 1 diabetes mellitus 15 10.5 GCG INS
16 secondary adrenal insufficiency 10.5 IGF1 INS
17 renal artery obstruction 10.5 ACE REN
18 cold agglutinin disease 10.5 CRP IL6
19 skin sarcoidosis 10.5 ACE TNF
20 uveoparotid fever 10.5 ACE TNF
21 angioimmunoblastic lymphadenopathy with dysproteinemia 10.4 IL6 TNF
22 drug reaction with eosinophilia and systemic symptoms 10.4 CRP TNF
23 autoimmune myocarditis 10.4 PPARG TNF
24 subacute cutaneous lupus erythematosus 10.4 ACE TNF
25 acute adrenal insufficiency 10.4 IL6 REN
26 severe pre-eclampsia 10.4 ADIPOQ ALB LEP
27 autosomal genetic disease 10.4 INS PSMD9 TRPV1
28 scorpion envenomation 10.4 IL6 TNF
29 leukomalacia 10.4 IL6 TNF
30 disease of mental health 10.4 BACE1 PSMD9 TRPV1
31 aortic valve disease 2 10.4 ACE CRP REN
32 hyperthyroidism 10.4 GHRL INS LEP
33 aortic aneurysm, familial abdominal, 1 10.4 ACE CRP IL6
34 carpal tunnel syndrome 10.4 IL6 INS PSMD9
35 eating disorder 10.4 ADIPOQ GHRL LEP
36 membranous nephropathy 10.4 ACE ALB TNF
37 carotid artery disease 10.4 ACE CRP REN
38 autoimmune disease of central nervous system 10.4 IL6 TNF TRPV1
39 acromegaly 10.4 GHRL IGF1 INS
40 dry eye syndrome 10.4 IL6 TNF TRPV1
41 male reproductive system disease 10.4 IGF1 IL6 TRPV1
42 bronchitis 10.4 ALB CRP TNF
43 bronchial disease 10.4 IL6 TNF TRPV1
44 otitis media 10.4 ALB IL6 TNF
45 craniopharyngioma 10.4 GHRL IGF1 INS
46 alcoholic hepatitis 10.4 ALB IL6 TNF
47 takayasu arteritis 10.4 CRP IL6 TNF
48 gastroesophageal reflux 10.4 GCG GHRL TRPV1
49 female reproductive system disease 10.4 IL6 TNF TRPV1
50 trypanosomiasis 10.4 ALB IL6 TNF

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:



Diseases related to Acquired Metabolic Disease

Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.43 ACE ADIPOQ ALB BACE1 CRP DPP4
2 cardiovascular system MP:0005385 10.39 ACE ADIPOQ CRP IGF1 IL6 INS
3 growth/size/body region MP:0005378 10.39 ACE ADIPOQ BACE1 DPP4 IGF1 IL6
4 endocrine/exocrine gland MP:0005379 10.37 ACE ADIPOQ ALB DPP4 GHRL IGF1
5 adipose tissue MP:0005375 10.35 ACE ADIPOQ GHRL IGF1 IL6 INS
6 cellular MP:0005384 10.35 ADIPOQ ALB BACE1 IGF1 IL6 INS
7 behavior/neurological MP:0005386 10.3 ACE ADIPOQ BACE1 GHRL IL6 INS
8 immune system MP:0005387 10.3 ACE ADIPOQ CRP IGF1 IL6 INS
9 hematopoietic system MP:0005397 10.24 ACE ADIPOQ IGF1 IL6 INS IRS1
10 mortality/aging MP:0010768 10.21 ACE ADIPOQ ALB BACE1 IGF1 IL6
11 liver/biliary system MP:0005370 10.14 ACE ADIPOQ ALB IL6 INS IRS1
12 muscle MP:0005369 10.1 ADIPOQ ALB BACE1 IGF1 IL6 INS
13 integument MP:0010771 10.09 ADIPOQ BACE1 IGF1 IL6 INS LEP
14 neoplasm MP:0002006 9.91 ACE ADIPOQ ALB IGF1 IL6 LEP
15 nervous system MP:0003631 9.9 ADIPOQ BACE1 IGF1 IL6 INS LEP
16 renal/urinary system MP:0005367 9.65 ACE ADIPOQ ALB IGF1 IL6 INS
17 skeleton MP:0005390 9.28 ADIPOQ IGF1 IL6 INS IRS1 LEP

Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

Genetic Tests for Acquired Metabolic Disease

Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

41
Kidney, Liver, Heart, Pancreas

Publications for Acquired Metabolic Disease

Variations for Acquired Metabolic Disease

Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 30)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.75 ACE BACE1 DPP4 GCG GHRL IGF1
2
Show member pathways
13.49 ADIPOQ BACE1 GCG IL6 INS IRS1
3
Show member pathways
13.45 ADIPOQ INS IRS1 LEP PPARG PSMD9
4
Show member pathways
13.01 ACE IGF1 IL6 INS IRS1 REN
5
Show member pathways
12.68 ADIPOQ IL6 INS IRS1 LEP SLC2A4
6 12.46 ADIPOQ GCG INS IRS1 PPARG SLC2A4
7
Show member pathways
12.29 ALB CRP IL6 INS TNF
9
Show member pathways
12.22 ADIPOQ IGF1 INS IRS1 LEP PPARG
10
Show member pathways
12.16 ACE IGF1 IL6 TNF
11
Show member pathways
12.15 INS IRS1 LEP SLC2A4
12
Show member pathways
12.09 ADIPOQ IGF1 INS IRS1 PPARG
13
Show member pathways
12.02 ACE DPP4 GCG GHRL IGF1 INS
14
Show member pathways
12.01 IGF1 IL6 INS IRS1 SLC2A4
15 12 ALB IGF1 IL6 INS
16
Show member pathways
11.84 IL6 INS IRS1 SLC2A4 TNF
17
Show member pathways
11.75 ADIPOQ INS IRS1 SLC2A4 TNF
18 11.73 ADIPOQ IGF1 IL6 INS IRS1 LEP
19 11.68 IGF1 IL6 PPARG TNF
20 11.62 IGF1 IL6 TNF
21
Show member pathways
11.56 DPP4 GCG LEP
22 11.56 ADIPOQ IRS1 LEP SLC2A4 TNF
23 11.51 IRS1 LEP SLC2A4
24 11.48 INS IRS1 LEP
25 11.46 IGF1 IL6 INS
26 11.39 IGF1 IL6 PTH TNF
27 11.34 IGF1 INS IRS1
28 11.14 ADIPOQ LEP PPARG
29 10.99 CRP IL6 TNF
30 10.51 ADIPOQ IL6 IRS1 LEP PPARG SLC2A4

GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.8 ACE ADIPOQ ALB CRP DPP4 GCG
2 endoplasmic reticulum lumen GO:0005788 9.63 ALB BACE1 GCG GHRL IL6 INS
3 membrane raft GO:0045121 9.56 BACE1 DPP4 SLC2A4 TNF
4 extracellular space GO:0005615 9.44 ACE ADIPOQ ALB CRP GCG GHRL

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.93 ALB BACE1 IGF1 IL6 INS
2 positive regulation of protein kinase B signaling GO:0051897 9.92 INS IRS1 LEP TNF
3 positive regulation of MAPK cascade GO:0043410 9.89 IGF1 IL6 INS LEP
4 response to ethanol GO:0045471 9.87 ADIPOQ LEP PTH SLC2A4
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 ADIPOQ IGF1 IL6
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 GCG IL6 TNF
7 response to nutrient GO:0007584 9.85 ADIPOQ LEP PPARG
8 cellular response to insulin stimulus GO:0032869 9.85 ADIPOQ IRS1 PPARG SLC2A4
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IGF1 IL6 LEP
10 response to glucocorticoid GO:0051384 9.83 ADIPOQ IL6 TNF
11 positive regulation of protein kinase activity GO:0045860 9.81 ADIPOQ GCG TNF
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.81 IGF1 IL6 TNF
13 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.81 IGF1 INS LEP TNF
14 hormone-mediated signaling pathway GO:0009755 9.8 GHRL PPARG REN
15 regulation of insulin secretion GO:0050796 9.8 DPP4 GCG LEP TNF
16 negative regulation of fat cell differentiation GO:0045599 9.79 ADIPOQ IL6 TNF
17 glucose metabolic process GO:0006006 9.77 ADIPOQ GHRL INS LEP TNF
18 acute-phase response GO:0006953 9.76 CRP IL6 INS
19 regulation of blood pressure GO:0008217 9.76 ACE LEP PPARG REN
20 negative regulation of insulin secretion GO:0046676 9.73 GHRL IRS1 PSMD9
21 glucose homeostasis GO:0042593 9.73 ADIPOQ INS IRS1 LEP PPARG SLC2A4
22 response to nutrient levels GO:0031667 9.71 ADIPOQ GHRL LEP PTH
23 positive regulation of insulin receptor signaling pathway GO:0046628 9.7 INS IRS1 LEP
24 regulation of protein secretion GO:0050708 9.68 INS TNF
25 angiotensin maturation GO:0002003 9.67 ACE REN
26 adult feeding behavior GO:0008343 9.67 GHRL LEP
27 negative regulation of blood vessel diameter GO:0097756 9.66 CRP INS
28 neutrophil mediated immunity GO:0002446 9.65 ACE IL6
29 amyloid-beta metabolic process GO:0050435 9.65 ACE BACE1 REN
30 negative regulation of acute inflammatory response GO:0002674 9.64 INS PPARG
31 positive regulation of neuroinflammatory response GO:0150078 9.63 IL6 TNF
32 positive regulation of glycogen biosynthetic process GO:0045725 9.62 IGF1 INS IRS1 PTH
33 bone mineralization involved in bone maturation GO:0035630 9.61 IGF1 LEP
34 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.61 ADIPOQ CRP PPARG
35 negative regulation of lipid storage GO:0010888 9.46 CRP IL6 LEP TNF
36 positive regulation of glucose import GO:0046326 9.35 ADIPOQ IGF1 INS IRS1 PTH
37 regulation of signaling receptor activity GO:0010469 9.28 ADIPOQ GCG GHRL IGF1 IL6 INS
38 negative regulation of apoptotic process GO:0043066 10.08 ALB GCG GHRL IGF1 IL6 LEP
39 positive regulation of cell proliferation GO:0008284 10.05 DPP4 IGF1 IL6 INS IRS1 LEP
40 positive regulation of gene expression GO:0010628 10.04 CRP IGF1 IL6 INS TNF

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.81 ADIPOQ ALB CRP DPP4 GCG INS
2 signaling receptor binding GO:0005102 9.72 ADIPOQ DPP4 GCG LEP REN
3 endopeptidase activity GO:0004175 9.61 ACE BACE1 REN
4 drug binding GO:0008144 9.54 ACE ALB PPARG
5 insulin receptor binding GO:0005158 9.43 IGF1 INS IRS1
6 peptide hormone receptor binding GO:0051428 9.4 LEP PTH
7 insulin-like growth factor receptor binding GO:0005159 9.26 IGF1 INS IRS1 REN
8 hormone activity GO:0005179 9.17 ADIPOQ GCG GHRL IGF1 INS LEP

Sources for Acquired Metabolic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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