Acquired Metabolic Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACQ009 MIFTS: 33	Acquired Metabolic Disease Categories: Genetic diseases, Metabolic diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease ¹² ¹⁵ ¹⁷

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases Genetic diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060158

EFO ¹⁷ EFO_1000639

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Summaries for Acquired Metabolic Disease

Disease Ontology : ¹² A disease of metabolism that has material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to hyperuricemia and hyperprolactinemia. An important gene associated with Acquired Metabolic Disease is INS (Insulin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Developmental Biology. Affiliated tissues include liver, and related phenotypes are homeostasis/metabolism and cardiovascular system

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Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder

Metabolic Disease Due to Other Fatty Acid Oxidation Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)

#	Related Disease	Score	Top Affiliating Genes
1	hyperuricemia	33.1	REN INS CRP
2	hyperprolactinemia	11.1
3	mineral metabolism disease	11.1
4	metabolic acidosis	11.1
5	amyloidosis	11.1
6	lipodystrophy, familial partial, type 1	11.1	PPARG LEP INS
7	abdominal obesity-metabolic syndrome quantitative trait locus 2	11.1	SLC2A4 LEP INS
8	lipodystrophy, congenital generalized, type 1	11.1	LEP INS ADIPOQ
9	obesity-hypoventilation syndrome	11.1	LEP IL6 ADIPOQ
10	complete generalized lipodystrophy	11.1	PPARG LEP INS
11	fatty liver disease, nonalcoholic 1	11.1	LEP INS ADIPOQ
12	loeffler syndrome	11.1	ALB ACE
13	microvascular complications of diabetes 3	11.1	INS ALB ACE
14	hypertensive retinopathy	11.1	REN ADIPOQ ACE
15	hypoaldosteronism	11.1	REN ACE
16	malignant otitis externa	11.1	INS CRP
17	orthostatic proteinuria	11.1	REN ALB ACE
18	nontuberculous mycobacterial lung disease	11.1	TNF LEP ADIPOQ
19	acquired generalized lipodystrophy	11.1	PPARG LEP INS ADIPOQ
20	fetal macrosomia	11.1	LEP INS IGF1
21	familial partial lipodystrophy	11.1	PPARG LEP INS
22	mixed cell adenoma	11.1	IRS1 IGF1
23	autoimmune myocarditis	11.1	TNF PPARG IL6
24	anuria	11.1	REN ALB ACE
25	inherited metabolic disorder	11.1	LEP INS CRP ADIPOQ
26	idiopathic edema	11.1	PPARG INS ADIPOQ ACE
27	acute insulin response	11.1	INS GCG CRP
28	acute cystitis	11.1	IL6 CRP ALB
29	sleep disorder	11.1	LEP INS IL6 CRP
30	tuberculous peritonitis	11.1	TNF CRP ALB
31	acute pyelonephritis	11.1	IL6 CRP ALB
32	pyelitis	11.0	REN IL6 CRP
33	hepatorenal syndrome	11.0	REN ALB ACE
34	intermediate coronary syndrome	11.0	IL6 CRP ACE
35	anovulation	11.0	LEP INS IGF1 CRP
36	systolic heart failure	11.0	IL6 CRP ACE
37	renal hypertension	11.0	REN ALB ACE
38	central nervous system vasculitis	11.0	TNF IL6 CRP
39	posterior urethral valves	11.0	TNF IL6 ACE
40	louse-borne relapsing fever	11.0	TNF IL6 CRP
41	angina pectoris	11.0	IL6 CRP ACE
42	paraphimosis	11.0	SLC5A4 SLC5A2 DPP4
43	intermittent claudication	11.0	IL6 CRP ALB ACE
44	mycoplasma pneumoniae pneumonia	11.0	TNF IL6 CRP
45	coronary stenosis	11.0	IL6 CRP ALB ACE
46	interstitial nephritis	11.0	REN CRP ALB ACE
47	balanoposthitis	11.0	SLC5A4 SLC5A2 DPP4
48	severe pre-eclampsia	11.0	LEP ALB ADIPOQ
49	scorpion envenomation	11.0	TNF IL6
50	peripheral artery disease	11.0	IL6 CRP ACE

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:

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Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

⁴⁶ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.39	ACE ADIPOQ ALB CRP DPP4 GHRL
2	cardiovascular system	MP:0005385	10.35	ACE ADIPOQ CRP IGF1 IL6 INS
3	growth/size/body region	MP:0005378	10.35	ACE ADIPOQ DPP4 IAPP IGF1 IL6
4	endocrine/exocrine gland	MP:0005379	10.34	ACE ADIPOQ ALB DPP4 GHRL IGF1
5	adipose tissue	MP:0005375	10.33	ACE ADIPOQ GHRL IGF1 IL6 INS
6	immune system	MP:0005387	10.28	ACE ADIPOQ CRP IAPP IGF1 IL6
7	cellular	MP:0005384	10.26	ADIPOQ ALB IGF1 IL6 INS IRS1
8	hematopoietic system	MP:0005397	10.23	ACE ADIPOQ IAPP IGF1 IL6 INS
9	mortality/aging	MP:0010768	10.13	ACE ADIPOQ ALB IGF1 IL6 INS
10	digestive/alimentary	MP:0005381	10.11	ALB GHRL IL6 INS LEP SLC2A4
11	liver/biliary system	MP:0005370	10.07	ACE ADIPOQ ALB IL6 INS IRS1
12	muscle	MP:0005369	10	ADIPOQ ALB IGF1 IL6 INS IRS1
13	neoplasm	MP:0002006	9.76	ACE ADIPOQ ALB IGF1 IL6 LEP
14	renal/urinary system	MP:0005367	9.65	ACE ADIPOQ ALB IGF1 IL6 INS
15	skeleton	MP:0005390	9.36	ADIPOQ IAPP IGF1 IL6 INS IRS1

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Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

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Genetic Tests for Acquired Metabolic Disease

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Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

⁴¹

Liver

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Publications for Acquired Metabolic Disease

Articles related to Acquired Metabolic Disease:

#	Title	Authors	PMID	Year
1	Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates. ³⁸	Ullah R...Fu J	30745819	2019
2	Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China. ³⁸	Guo M...Liu X	25688884	2015
3	[Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. ³⁸	Fraenkel E...Feher J	17452309	2007

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Genes for Acquired Metabolic Disease

Genes related to Acquired Metabolic Disease (0 elite genes):

(show top 50) (show all 62)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	INS	Insulin	Protein Coding	21.97	DISEASES inferred ¹⁵
2	LEP	Leptin	Protein Coding	20.2	DISEASES inferred ¹⁵
3	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	19.84	DISEASES inferred ¹⁵
4	ALB	Albumin	Protein Coding	19.55	DISEASES inferred ¹⁵
5	CRP	C-Reactive Protein	Protein Coding	19.33	DISEASES inferred ¹⁵
6	DPP4	Dipeptidyl Peptidase 4	Protein Coding	19.2	DISEASES inferred ¹⁵
7	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	19.11	DISEASES inferred ¹⁵
8	PTH	Parathyroid Hormone	Protein Coding	19.03	DISEASES inferred ¹⁵
9	ACE	Angiotensin I Converting Enzyme	Protein Coding	18.93	DISEASES inferred ¹⁵
10	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	18.84	DISEASES inferred ¹⁵
11	IL6	Interleukin 6	Protein Coding	18.81	DISEASES inferred ¹⁵
12	REN	Renin	Protein Coding	18.8	DISEASES inferred ¹⁵
13	IGF1	Insulin Like Growth Factor 1	Protein Coding	18.76	DISEASES inferred ¹⁵
14	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	18.64	DISEASES inferred ¹⁵
15	SLC5A2	Solute Carrier Family 5 Member 2	Protein Coding	18.58	DISEASES inferred ¹⁵
16	IRS1	Insulin Receptor Substrate 1	Protein Coding	18.55	DISEASES inferred ¹⁵
17	TNF	Tumor Necrosis Factor	Protein Coding	18.53	DISEASES inferred ¹⁵
18	IAPP	Islet Amyloid Polypeptide	Protein Coding	18.51	DISEASES inferred ¹⁵
19	GCG	Glucagon	Protein Coding	10.1	DISEASES inferred ¹⁵
20	SLC5A4	Solute Carrier Family 5 Member 4	Protein Coding	8.56	DISEASES inferred ¹⁵
21	RETN	Resistin	Protein Coding	8.51	DISEASES inferred ¹⁵
22	UCP1	Uncoupling Protein 1	Protein Coding	8.47	DISEASES inferred ¹⁵
23	APOB	Apolipoprotein B	Protein Coding	8.44	DISEASES inferred ¹⁵
24	GIP	Gastric Inhibitory Polypeptide	Protein Coding	8.43	DISEASES inferred ¹⁵
25	TTR	Transthyretin	Protein Coding	8.43	DISEASES inferred ¹⁵
26	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	8.41	DISEASES inferred ¹⁵
27	POMC	Proopiomelanocortin	Protein Coding	8.38	DISEASES inferred ¹⁵
28	COG2	Component Of Oligomeric Golgi Complex 2	Protein Coding	8.36	DISEASES inferred ¹⁵
29	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	8.35	DISEASES inferred ¹⁵
30	CNBP	CCHC-Type Zinc Finger Nucleic Acid Binding Protein	Protein Coding	8.29	DISEASES inferred ¹⁵
31	FTO	FTO Alpha-Ketoglutarate Dependent Dioxygenase	Protein Coding	8.28	DISEASES inferred ¹⁵
32	LEPR	Leptin Receptor	Protein Coding	8.24	DISEASES inferred ¹⁵
33	MC4R	Melanocortin 4 Receptor	Protein Coding	8.21	DISEASES inferred ¹⁵
34	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	8.2	DISEASES inferred ¹⁵
35	PRL	Prolactin	Protein Coding	8.15	DISEASES inferred ¹⁵
36	NPY	Neuropeptide Y	Protein Coding	8.15	DISEASES inferred ¹⁵
37	GCK	Glucokinase	Protein Coding	8.13	DISEASES inferred ¹⁵
38	IL1B	Interleukin 1 Beta	Protein Coding	8.11	DISEASES inferred ¹⁵
39	NOS3	Nitric Oxide Synthase 3	Protein Coding	8.1	DISEASES inferred ¹⁵
40	APOA1	Apolipoprotein A1	Protein Coding	8.08	DISEASES inferred ¹⁵
41	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	8.06	DISEASES inferred ¹⁵
42	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	8.06	DISEASES inferred ¹⁵
43	SERPINE1	Serpin Family E Member 1	Protein Coding	8.03	DISEASES inferred ¹⁵
44	GAD2	Glutamate Decarboxylase 2	Protein Coding	8.01	DISEASES inferred ¹⁵
45	KCNJ11	Potassium Inwardly Rectifying Channel Subfamily J Member 11	Protein Coding	8.01	DISEASES inferred ¹⁵
46	SST	Somatostatin	Protein Coding	7.98	DISEASES inferred ¹⁵
47	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	7.92	DISEASES inferred ¹⁵
48	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	7.91	DISEASES inferred ¹⁵
49	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	7.88	DISEASES inferred ¹⁵
50	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	7.87	DISEASES inferred ¹⁵

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Variations for Acquired Metabolic Disease

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Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

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Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁶ Show member pathways Alzheimer disease ³⁷ Alzheimers Disease ¹ Complex I biogenesis ⁶⁶ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁶ Huntington disease ³⁷ Non-alcoholic fatty liver disease (NAFLD) ³⁷ Oxidative phosphorylation ¹ Oxidative phosphorylation ³⁷ Parkinson disease ³⁷ Respiratory electron transport ⁶⁶ The citric acid (TCA) cycle and respiratory electron transport ⁶⁶ Thermogenesis ³⁷	13.5	TNF PPARG LEP IRS1 INS IL6
2	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.44	TNF SLC2A4 PPARG LEP IRS1 INS
3	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	13	REN IRS1 INS IL6 IGF1 ACE
4	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ IL-9 Signaling Pathways ⁶⁵ Immune response IL-9 signaling pathway ²²	12.7	TNF SLC2A4 LEP IRS1 INS IL6
5	Glucose / Energy Metabolism ⁴	12.4	SLC5A2 SLC2A4 PPARG IRS1 INS GCG
6	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.29	TNF INS IL6 CRP ALB
7	Circadian rythm related genes ¹	12.26	PPARG LEP IL6 GHRL ADIPOQ
8	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁷ AMPK Signaling Pathway ⁶⁷	12.21	SLC2A4 PPARG LEP IRS1 INS IGF1
9	Dilated cardiomyopathy (DCM) ³⁷ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁷	12.18	TNF IL6 IGF1 ACE
10	AMPK Enzyme Complex Pathway ⁶⁴ Show member pathways Chromatin Remodeling ⁶⁴ mitochondrial L-carnitine shuttle ¹	12.14	SLC2A4 LEP IRS1 INS
11	Longevity regulating pathway ³⁷ Show member pathways Longevity regulating pathway - multiple species ³⁷	12.09	PPARG IRS1 INS IGF1 ADIPOQ
12	FoxO signaling pathway ³⁷ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	12.03	SLC2A4 IRS1 INS IL6 IGF1
13	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Insulin processing ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶	12.02	REN LEP INS IGF1 GHRL GCG
14	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12	INS IL6 IGF1 ALB
15	Insulin resistance ³⁷ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.87	TNF SLC2A4 IRS1 INS IL6
16	Type II diabetes mellitus ¹ ³⁷ Show member pathways Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶¹	11.78	TNF SLC2A4 IRS1 INS ADIPOQ
17	Adipogenesis ¹	11.73	TNF SLC2A4 PPARG LEP IRS1 INS
18	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.68	TNF PPARG IL6 IGF1
19	Lung fibrosis ¹	11.61	TNF IL6 IGF1
20	Adipocytokine signaling pathway ³⁷	11.56	TNF SLC2A4 LEP IRS1 ADIPOQ
21	Incretin synthesis, secretion, and inactivation ⁶⁶ Show member pathways Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ⁶⁶ Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) ⁶⁶	11.55	LEP GCG DPP4
22	Development_Leptin signaling via PI3K-dependent pathway ²²	11.51	SLC2A4 LEP IRS1
23	Signaling events mediated by PTP1B ¹	11.47	LEP IRS1 INS
24	Differentiation Pathway ¹	11.45	INS IL6 IGF1
25	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.41	TNF PTH IL6 IGF1
26	Aldosterone-regulated sodium reabsorption ³⁷	11.33	IRS1 INS IGF1
27	Differentiation of white and brown adipocyte ¹	11.14	PPARG LEP ADIPOQ
28	Overview of nanoparticle effects ¹	10.99	TNF IL6 CRP
29	Transcription factor regulation in adipogenesis ¹	10.51	TNF SLC2A4 PPARG LEP IRS1 IL6

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GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.83	TNF REN PTH LEP INS IL6
2	endoplasmic reticulum lumen	GO:0005788	9.55	INS IL6 GHRL GCG ALB
3	extracellular space	GO:0005615	9.47	TNF REN PTH LEP INS IL6

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 40)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein metabolic process	GO:0044267	9.95	INS IL6 IGF1 IAPP ALB
2	response to ethanol	GO:0045471	9.87	SLC2A4 PTH LEP ADIPOQ
3	cellular response to insulin stimulus	GO:0032869	9.86	SLC2A4 PPARG IRS1 ADIPOQ
4	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.85	IL6 IGF1 ADIPOQ
5	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.85	TNF IL6 GCG
6	response to nutrient	GO:0007584	9.85	PPARG LEP ADIPOQ
7	positive regulation of protein kinase B signaling	GO:0051897	9.85	TNF LEP IRS1 INS IAPP
8	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.83	LEP IL6 IGF1
9	response to glucocorticoid	GO:0051384	9.82	TNF IL6 ADIPOQ
10	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.81	TNF LEP INS IGF1
11	positive regulation of protein kinase activity	GO:0045860	9.8	TNF GCG ADIPOQ
12	positive regulation of smooth muscle cell proliferation	GO:0048661	9.8	TNF IL6 IGF1
13	regulation of insulin secretion	GO:0050796	9.8	TNF LEP GCG DPP4
14	hormone-mediated signaling pathway	GO:0009755	9.79	REN PPARG GHRL
15	negative regulation of fat cell differentiation	GO:0045599	9.78	TNF IL6 ADIPOQ
16	regulation of blood pressure	GO:0008217	9.78	REN PPARG LEP ACE
17	positive regulation of MAPK cascade	GO:0043410	9.77	LEP INS IL6 IGF1 IAPP
18	acute-phase response	GO:0006953	9.76	INS IL6 CRP
19	glucose metabolic process	GO:0006006	9.72	TNF LEP INS GHRL ADIPOQ
20	glucose transmembrane transport	GO:1904659	9.71	SLC5A4 SLC5A2 SLC2A4
21	response to nutrient levels	GO:0031667	9.71	PTH LEP GHRL ADIPOQ
22	positive regulation of insulin receptor signaling pathway	GO:0046628	9.7	LEP IRS1 INS
23	regulation of protein secretion	GO:0050708	9.68	TNF INS
24	negative regulation of bone resorption	GO:0045779	9.68	IL6 IAPP
25	angiotensin maturation	GO:0002003	9.67	REN ACE
26	positive regulation of protein kinase A signaling	GO:0010739	9.66	IAPP ADIPOQ
27	negative regulation of blood vessel diameter	GO:0097756	9.66	INS CRP
28	adult feeding behavior	GO:0008343	9.65	LEP GHRL
29	neutrophil mediated immunity	GO:0002446	9.64	IL6 ACE
30	negative regulation of acute inflammatory response	GO:0002674	9.63	PPARG INS
31	glucose homeostasis	GO:0042593	9.63	SLC2A4 PPARG LEP IRS1 INS ADIPOQ
32	positive regulation of neuroinflammatory response	GO:0150078	9.62	TNF IL6
33	negative regulation of macrophage derived foam cell differentiation	GO:0010745	9.61	PPARG CRP ADIPOQ
34	bone mineralization involved in bone maturation	GO:0035630	9.6	LEP IGF1
35	positive regulation of glycogen biosynthetic process	GO:0045725	9.56	PTH IRS1 INS IGF1
36	negative regulation of lipid storage	GO:0010888	9.26	TNF LEP IL6 CRP
37	positive regulation of glucose import	GO:0046326	9.02	PTH IRS1 INS IGF1 ADIPOQ
38	negative regulation of apoptotic process	GO:0043066	10.07	LEP IL6 IGF1 GHRL GCG ALB
39	positive regulation of cell proliferation	GO:0008284	10.05	LEP IRS1 INS IL6 IGF1 DPP4
40	positive regulation of gene expression	GO:0010628	10.04	TNF INS IL6 IGF1 CRP

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.81	TNF PPARG INS IAPP GCG DPP4
2	signaling receptor binding	GO:0005102	9.73	REN LEP IAPP GCG DPP4 ADIPOQ
3	drug binding	GO:0008144	9.58	PPARG ALB ACE
4	insulin receptor binding	GO:0005158	9.5	IRS1 INS IGF1
5	peptide hormone receptor binding	GO:0051428	9.43	PTH LEP
6	glucose:sodium symporter activity	GO:0005412	9.37	SLC5A4 SLC5A2
7	insulin-like growth factor receptor binding	GO:0005159	9.26	REN IRS1 INS IGF1
8	hormone activity	GO:0005179	9.23	PTH LEP INS IGF1 IAPP GHRL

Sources

Sources for Acquired Metabolic Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

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³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

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⁴¹ MalaCards

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⁴⁸ NCBI Bookshelf

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⁵¹ NDF-RT

⁵² NIH Clinical Center

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⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ TGDB

⁷¹ Tocris

⁷² UMLS

⁷³ UMLS via Orphanet

⁷⁴ UniProtKB/Swiss-Prot

⁷⁵ Wikipedia