Acquired Metabolic Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACQ009 MIFTS: 35	Acquired Metabolic Disease Categories: Metabolic diseases
Genes Tissues Related diseases Pathways Expand all tables

Sources

Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease ¹² ¹⁵ ¹⁷

Classifications:

MalaCards categories:
Global: Metabolic diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060158

EFO ¹⁷ EFO_1000639

Sources

Summaries for Acquired Metabolic Disease

Disease Ontology : ¹² A disease of metabolism that has _material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to hyperuricemia and hyperprolactinemia. An important gene associated with Acquired Metabolic Disease is INS (Insulin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Developmental Biology. Affiliated tissues include heart, liver and kidney, and related phenotypes are homeostasis/metabolism and cardiovascular system

Sources

Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)

#	Related Disease	Score	Top Affiliating Genes
1	hyperuricemia	32.5	CRP INS REN
2	hyperprolactinemia	11.0
3	mineral metabolism disease	11.0
4	metabolic acidosis	11.0
5	amyloidosis	11.0
6	severe nonproliferative diabetic retinopathy	10.7	ALB INS
7	scleredema adultorum	10.7	INS PTH
8	idiopathic recurrent pericarditis	10.7	ADIPOQ LEP
9	pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	10.7	IGF1 INS
10	benign essential hypertension	10.7	ALB REN
11	generalized atherosclerosis	10.7	ACE CRP
12	kidney papillary necrosis	10.7	ALB REN
13	hyperinsulinemic hypoglycemia, familial, 7	10.7	GCG INS
14	secondary adrenal insufficiency	10.7	IGF1 INS
15	renal artery obstruction	10.7	ACE REN
16	cold agglutinin disease	10.7	CRP IL6
17	skin sarcoidosis	10.7	ACE TNF
18	uveoparotid fever	10.7	ACE TNF
19	nonalcoholic fatty liver disease	10.7	ADIPOQ INS LEP
20	drug reaction with eosinophilia and systemic symptoms	10.7	CRP TNF
21	acute adrenal insufficiency	10.7	IL6 REN
22	angioimmunoblastic lymphadenopathy with dysproteinemia	10.7	IL6 TNF
23	subacute cutaneous lupus erythematosus	10.7	ACE TNF
24	leukomalacia	10.7	IL6 TNF
25	hyperthyroidism	10.7	GHRL INS LEP
26	aortic valve disease 2	10.7	ACE CRP REN
27	eating disorder	10.7	ADIPOQ GHRL LEP
28	acromegaly	10.7	GHRL IGF1 INS
29	membranous nephropathy	10.7	ACE ALB TNF
30	bronchitis	10.7	ALB CRP TNF
31	otitis media	10.7	ALB IL6 TNF
32	trypanosomiasis	10.7	ALB IL6 TNF
33	chlamydia	10.7	CRP IL6 TNF
34	gastrointestinal system cancer	10.7	ALB IL6 TNF
35	bronchiolitis	10.7	CRP IL6 TNF
36	synovitis	10.7	CRP IL6 TNF
37	acquired immunodeficiency syndrome	10.7	ALB IL6 TNF
38	purpura	10.7	CRP IL6 TNF
39	insulinoma	10.7	GCG IAPP INS
40	bone inflammation disease	10.7	CRP IL6 TNF
41	mouth disease	10.7	CRP IL6 TNF
42	spondylitis	10.7	CRP IL6 TNF
43	chagas disease	10.7	ACE IL6 TNF
44	juvenile rheumatoid arthritis	10.7	CRP IL6 TNF
45	periodontitis	10.7	CRP IL6 TNF
46	lipodystrophy, familial partial, type 1	10.7	INS LEP PPARG
47	monocytic leukemia	10.7	IL6 PPARG TNF
48	abdominal obesity-metabolic syndrome quantitative trait locus 2	10.7	INS LEP SLC2A4
49	reproductive system disease	10.7	IGF1 IL6 TNF
50	obesity-hypoventilation syndrome	10.7	ADIPOQ IL6 LEP

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:

Sources

Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

⁴⁷ (show all 15)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.39	ACE ADIPOQ ALB CRP DPP4 GHRL
2	cardiovascular system	MP:0005385	10.35	ACE ADIPOQ CRP IGF1 IL6 INS
3	growth/size/body region	MP:0005378	10.35	ACE ADIPOQ DPP4 IAPP IGF1 IL6
4	endocrine/exocrine gland	MP:0005379	10.34	ACE ADIPOQ ALB DPP4 GHRL IGF1
5	adipose tissue	MP:0005375	10.33	ACE ADIPOQ GHRL IGF1 IL6 INS
6	immune system	MP:0005387	10.28	ACE ADIPOQ CRP IAPP IGF1 IL6
7	cellular	MP:0005384	10.26	ADIPOQ ALB IGF1 IL6 INS IRS1
8	hematopoietic system	MP:0005397	10.23	ACE ADIPOQ IAPP IGF1 IL6 INS
9	mortality/aging	MP:0010768	10.13	ACE ADIPOQ ALB IGF1 IL6 INS
10	digestive/alimentary	MP:0005381	10.11	ALB GHRL IL6 INS LEP SLC2A4
11	liver/biliary system	MP:0005370	10.07	ACE ADIPOQ ALB IL6 INS IRS1
12	muscle	MP:0005369	10	ADIPOQ ALB IGF1 IL6 INS IRS1
13	neoplasm	MP:0002006	9.76	ACE ADIPOQ ALB IGF1 IL6 LEP
14	renal/urinary system	MP:0005367	9.65	ACE ADIPOQ ALB IGF1 IL6 INS
15	skeleton	MP:0005390	9.36	ADIPOQ IAPP IGF1 IL6 INS IRS1

Sources

Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

Sources

Genetic Tests for Acquired Metabolic Disease

Sources

Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

⁴²

Heart, Liver, Kidney, Bone, Pancreas, Lung, Lymph Node

Sources

Publications for Acquired Metabolic Disease

Sources

Genes for Acquired Metabolic Disease

Genes related to Acquired Metabolic Disease (0 elite genes):

(show top 50) (show all 60)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	INS	Insulin	Protein Coding	21.97	DISEASES inferred ¹⁵
2	LEP	Leptin	Protein Coding	20.2	DISEASES inferred ¹⁵
3	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	19.84	DISEASES inferred ¹⁵
4	ALB	Albumin	Protein Coding	19.57	DISEASES inferred ¹⁵
5	CRP	C-Reactive Protein	Protein Coding	19.34	DISEASES inferred ¹⁵
6	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	19.3	DISEASES inferred ¹⁵
7	DPP4	Dipeptidyl Peptidase 4	Protein Coding	19.19	DISEASES inferred ¹⁵
8	PTH	Parathyroid Hormone	Protein Coding	19.05	DISEASES inferred ¹⁵
9	ACE	Angiotensin I Converting Enzyme	Protein Coding	18.95	DISEASES inferred ¹⁵
10	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	18.85	DISEASES inferred ¹⁵
11	REN	Renin	Protein Coding	18.81	DISEASES inferred ¹⁵
12	IL6	Interleukin 6	Protein Coding	18.81	DISEASES inferred ¹⁵
13	IGF1	Insulin Like Growth Factor 1	Protein Coding	18.79	DISEASES inferred ¹⁵
14	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	18.66	DISEASES inferred ¹⁵
15	IRS1	Insulin Receptor Substrate 1	Protein Coding	18.56	DISEASES inferred ¹⁵
16	SLC5A2	Solute Carrier Family 5 Member 2	Protein Coding	18.56	DISEASES inferred ¹⁵
17	IAPP	Islet Amyloid Polypeptide	Protein Coding	18.52	DISEASES inferred ¹⁵
18	TNF	Tumor Necrosis Factor	Protein Coding	18.52	DISEASES inferred ¹⁵
19	GCG	Glucagon	Protein Coding	10.12	DISEASES inferred ¹⁵
20	SLC5A4	Solute Carrier Family 5 Member 4	Protein Coding	8.53	DISEASES inferred ¹⁵
21	RETN	Resistin	Protein Coding	8.52	DISEASES inferred ¹⁵
22	TTR	Transthyretin	Protein Coding	8.49	DISEASES inferred ¹⁵
23	UCP1	Uncoupling Protein 1	Protein Coding	8.46	DISEASES inferred ¹⁵
24	APOB	Apolipoprotein B	Protein Coding	8.46	DISEASES inferred ¹⁵
25	GIP	Gastric Inhibitory Polypeptide	Protein Coding	8.44	DISEASES inferred ¹⁵
26	POMC	Proopiomelanocortin	Protein Coding	8.41	DISEASES inferred ¹⁵
27	COG2	Component Of Oligomeric Golgi Complex 2	Protein Coding	8.4	DISEASES inferred ¹⁵
28	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	8.39	DISEASES inferred ¹⁵
29	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	8.36	DISEASES inferred ¹⁵
30	FTO	FTO Alpha-Ketoglutarate Dependent Dioxygenase	Protein Coding	8.29	DISEASES inferred ¹⁵
31	LEPR	Leptin Receptor	Protein Coding	8.26	DISEASES inferred ¹⁵
32	PRL	Prolactin	Protein Coding	8.22	DISEASES inferred ¹⁵
33	MC4R	Melanocortin 4 Receptor	Protein Coding	8.22	DISEASES inferred ¹⁵
34	HBA1	Hemoglobin Subunit Alpha 1	Protein Coding	8.2	DISEASES inferred ¹⁵
35	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	8.2	DISEASES inferred ¹⁵
36	NPY	Neuropeptide Y	Protein Coding	8.19	DISEASES inferred ¹⁵
37	GCK	Glucokinase	Protein Coding	8.14	DISEASES inferred ¹⁵
38	NOS3	Nitric Oxide Synthase 3	Protein Coding	8.12	DISEASES inferred ¹⁵
39	IL1B	Interleukin 1 Beta	Protein Coding	8.1	DISEASES inferred ¹⁵
40	APOA1	Apolipoprotein A1	Protein Coding	8.09	DISEASES inferred ¹⁵
41	SST	Somatostatin	Protein Coding	8.07	DISEASES inferred ¹⁵
42	SERPINE1	Serpin Family E Member 1	Protein Coding	8.06	DISEASES inferred ¹⁵
43	GAD2	Glutamate Decarboxylase 2	Protein Coding	8.05	DISEASES inferred ¹⁵
44	KCNJ11	Potassium Voltage-Gated Channel Subfamily J Member 11	Protein Coding	8.02	DISEASES inferred ¹⁵
45	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	7.94	DISEASES inferred ¹⁵
46	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	7.92	DISEASES inferred ¹⁵
47	MGAM	Maltase-Glucoamylase	Protein Coding	7.9	DISEASES inferred ¹⁵
48	LPA	Lipoprotein(A)	Protein Coding	7.9	DISEASES inferred ¹⁵
49	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	7.9	DISEASES inferred ¹⁵
50	GPT	Glutamic--Pyruvic Transaminase	Protein Coding	7.88	DISEASES inferred ¹⁵

Sources

Variations for Acquired Metabolic Disease

Sources

Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

Sources

Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 29)

#	Super pathways	Score	Top Affiliating Genes
1	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁷ Show member pathways Alzheimer disease ³⁸ Alzheimers Disease ¹ Complex I biogenesis ⁶⁷ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁷ Huntington disease ³⁸ Non-alcoholic fatty liver disease (NAFLD) ³⁸ Oxidative phosphorylation ¹ Oxidative phosphorylation ³⁸ Parkinson disease ³⁸ Respiratory electron transport ⁶⁷ The citric acid (TCA) cycle and respiratory electron transport ⁶⁷ Thermogenesis ³⁸	13.5	ADIPOQ GCG IL6 INS IRS1 LEP
2	Developmental Biology ⁶⁷ Show member pathways Axon guidance ⁶⁷	13.44	ADIPOQ IAPP INS IRS1 LEP PPARG
3	p70S6K Signaling ⁶⁵ Show member pathways mTOR Pathway ⁶⁵ Renin-Angiotensin Pathway ⁶⁵	13	ACE IGF1 IL6 INS IRS1 REN
4	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁶ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁶ Development Thrombopoietin-regulated cell processes ²³ IL-15 Signaling Pathways ⁶⁶ IL-2 Signaling Pathways ⁶⁶ IL-21 Signaling Pathways ⁶⁶ IL-4 Signaling Pathways ⁶⁶ IL-7 Signaling Pathways ⁶⁶ IL-9 Pathway ⁶⁵ IL-9 Signaling Pathways ⁶⁶ Immune response IL-9 signaling pathway ²³	12.7	ADIPOQ IL6 INS IRS1 LEP SLC2A4
5	Glucose / Energy Metabolism ⁴	12.4	ADIPOQ GCG INS IRS1 PPARG SLC2A4
6	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁷ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.29	ALB CRP IL6 INS TNF
7	Circadian rythm related genes ¹	12.26	ADIPOQ GHRL IL6 LEP PPARG
8	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁸ AMPK Signaling Pathway ⁶⁸	12.22	ADIPOQ IGF1 INS IRS1 LEP PPARG
9	Dilated cardiomyopathy (DCM) ³⁸ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁸	12.16	ACE IGF1 IL6 TNF
10	AMPK Enzyme Complex Pathway ⁶⁵ Show member pathways Chromatin Remodeling ⁶⁵ mitochondrial L-carnitine shuttle ¹	12.14	INS IRS1 LEP SLC2A4
11	Longevity regulating pathway ³⁸ Show member pathways Longevity regulating pathway - multiple species ³⁸	12.09	ADIPOQ IGF1 INS IRS1 PPARG
12	FoxO signaling pathway ³⁸ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	12.03	IGF1 IL6 INS IRS1 SLC2A4
13	Peptide hormone metabolism ⁶⁷ Show member pathways Glycoprotein hormones ⁶⁷ Insulin processing ⁶⁷ Metabolism of Angiotensinogen to Angiotensins ⁶⁷ Peptide hormone biosynthesis ⁶⁷ Synthesis, secretion, and deacylation of Ghrelin ⁶⁷	12.02	ACE DPP4 GCG GHRL IGF1 INS
14	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁶	12	ALB IGF1 IL6 INS
15	Insulin resistance ³⁸ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.87	IL6 INS IRS1 SLC2A4 TNF
16	Type II diabetes mellitus ¹ ³⁸ Show member pathways Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶²	11.78	ADIPOQ INS IRS1 SLC2A4 TNF
17	Adipogenesis ¹	11.73	ADIPOQ IGF1 IL6 INS IRS1 LEP
18	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁶	11.68	IGF1 IL6 PPARG TNF
19	Lung fibrosis ¹	11.61	IGF1 IL6 TNF
20	Adipocytokine signaling pathway ³⁸	11.56	ADIPOQ IRS1 LEP SLC2A4 TNF
21	Incretin synthesis, secretion, and inactivation ⁶⁷ Show member pathways Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ⁶⁷ Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) ⁶⁷	11.55	DPP4 GCG LEP
22	Development_Leptin signaling via PI3K-dependent pathway ²³	11.51	IRS1 LEP SLC2A4
23	Signaling events mediated by PTP1B ¹	11.47	INS IRS1 LEP
24	Differentiation Pathway ¹	11.45	IGF1 IL6 INS
25	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²³	11.41	IGF1 IL6 PTH TNF
26	Aldosterone-regulated sodium reabsorption ³⁸	11.33	IGF1 INS IRS1
27	Differentiation of white and brown adipocyte ¹	11.14	ADIPOQ LEP PPARG
28	Overview of nanoparticle effects ¹	10.99	CRP IL6 TNF
29	Transcription factor regulation in adipogenesis ¹	10.51	ADIPOQ IL6 IRS1 LEP PPARG SLC2A4

Sources

GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.83	ACE ADIPOQ ALB CRP DPP4 GCG
2	endoplasmic reticulum lumen	GO:0005788	9.55	ALB GCG GHRL IL6 INS
3	extracellular space	GO:0005615	9.47	ACE ADIPOQ ALB CRP GCG GHRL

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 41)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein metabolic process	GO:0044267	9.96	ALB IAPP IGF1 IL6 INS
2	response to ethanol	GO:0045471	9.88	ADIPOQ LEP PTH SLC2A4
3	positive regulation of protein kinase B signaling	GO:0051897	9.88	IAPP INS IRS1 LEP TNF
4	cellular response to insulin stimulus	GO:0032869	9.87	ADIPOQ IRS1 PPARG SLC2A4
5	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.85	ADIPOQ IGF1 IL6
6	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.85	GCG IL6 TNF
7	response to nutrient	GO:0007584	9.85	ADIPOQ LEP PPARG
8	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.83	IGF1 IL6 LEP
9	response to glucocorticoid	GO:0051384	9.83	ADIPOQ IL6 TNF
10	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.83	IGF1 INS LEP TNF
11	positive regulation of protein kinase activity	GO:0045860	9.81	ADIPOQ GCG TNF
12	regulation of insulin secretion	GO:0050796	9.81	DPP4 GCG LEP TNF
13	positive regulation of smooth muscle cell proliferation	GO:0048661	9.8	IGF1 IL6 TNF
14	regulation of blood pressure	GO:0008217	9.8	ACE LEP PPARG REN
15	positive regulation of MAPK cascade	GO:0043410	9.8	IAPP IGF1 IL6 INS LEP
16	hormone-mediated signaling pathway	GO:0009755	9.79	GHRL PPARG REN
17	negative regulation of fat cell differentiation	GO:0045599	9.79	ADIPOQ IL6 TNF
18	acute-phase response	GO:0006953	9.77	CRP IL6 INS
19	glucose metabolic process	GO:0006006	9.77	ADIPOQ GHRL INS LEP TNF
20	response to nutrient levels	GO:0031667	9.73	ADIPOQ GHRL LEP PTH
21	glucose homeostasis	GO:0042593	9.73	ADIPOQ INS IRS1 LEP PPARG SLC2A4
22	glucose transmembrane transport	GO:1904659	9.72	SLC2A4 SLC5A2 SLC5A4
23	positive regulation of insulin receptor signaling pathway	GO:0046628	9.71	INS IRS1 LEP
24	negative regulation of bone resorption	GO:0045779	9.68	IAPP IL6
25	regulation of protein secretion	GO:0050708	9.68	INS TNF
26	angiotensin maturation	GO:0002003	9.67	ACE REN
27	adult feeding behavior	GO:0008343	9.67	GHRL LEP
28	negative regulation of blood vessel diameter	GO:0097756	9.66	CRP INS
29	positive regulation of protein kinase A signaling	GO:0010739	9.66	ADIPOQ IAPP
30	neutrophil mediated immunity	GO:0002446	9.65	ACE IL6
31	negative regulation of acute inflammatory response	GO:0002674	9.64	INS PPARG
32	negative regulation of macrophage derived foam cell differentiation	GO:0010745	9.63	ADIPOQ CRP PPARG
33	positive regulation of neuroinflammatory response	GO:0150078	9.62	IL6 TNF
34	positive regulation of glycogen biosynthetic process	GO:0045725	9.62	IGF1 INS IRS1 PTH
35	bone mineralization involved in bone maturation	GO:0035630	9.61	IGF1 LEP
36	negative regulation of lipid storage	GO:0010888	9.46	CRP IL6 LEP TNF
37	positive regulation of glucose import	GO:0046326	9.35	ADIPOQ IGF1 INS IRS1 PTH
38	regulation of signaling receptor activity	GO:0010469	9.32	ADIPOQ GCG GHRL IAPP IGF1 IL6
39	negative regulation of apoptotic process	GO:0043066	10.08	ALB GCG GHRL IGF1 IL6 LEP
40	positive regulation of cell proliferation	GO:0008284	10.06	DPP4 IGF1 IL6 INS IRS1 LEP
41	positive regulation of gene expression	GO:0010628	10.04	CRP IGF1 IL6 INS TNF

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.81	ADIPOQ ALB CRP DPP4 GCG IAPP
2	signaling receptor binding	GO:0005102	9.73	ADIPOQ DPP4 GCG IAPP LEP REN
3	drug binding	GO:0008144	9.58	ACE ALB PPARG
4	insulin receptor binding	GO:0005158	9.5	IGF1 INS IRS1
5	peptide hormone receptor binding	GO:0051428	9.43	LEP PTH
6	glucose:sodium symporter activity	GO:0005412	9.37	SLC5A2 SLC5A4
7	insulin-like growth factor receptor binding	GO:0005159	9.26	IGF1 INS IRS1 REN
8	hormone activity	GO:0005179	9.23	ADIPOQ GCG GHRL IAPP IGF1 INS

Sources

Sources for Acquired Metabolic Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FDA Approved Drugs

²⁰ FMA

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ Genetics Home Reference

²⁷ GenomeRNAi

²⁸ GEO DataSets

²⁹ GO

³⁰ GTR

³¹ HGMD

³² HMDB

³³ HPO

³⁴ ICD10

³⁵ ICD10 via Orphanet

³⁶ ICD9CM

³⁷ IUPHAR

³⁸ KEGG

³⁹ LifeMap

⁴⁰ LncRNADisease

⁴¹ LOVD

⁴² MalaCards

⁴³ MedGen

⁴⁴ MedlinePlus

⁴⁵ MeSH

⁴⁶ MESH via Orphanet

⁴⁷ MGI

⁴⁸ miR2Disease

⁴⁹ NCBI Bookshelf

⁵⁰ NCI

⁵¹ NCIt

⁵² NDF-RT

⁵³ NIH Clinical Center

⁵⁴ NIH Rare Diseases

⁵⁵ NINDS

⁵⁶ Novoseek

⁵⁷ Novus Biologicals

⁵⁸ OMIM

⁵⁹ OMIM via Orphanet

⁶⁰ Orphanet

⁶¹ PathCards

⁶² PharmGKB

⁶³ PubMed

⁶⁴ PubMed Health

⁶⁵ QIAGEN

⁶⁶ R&D Systems

⁶⁷ Reactome

⁶⁸ Sino Biological

⁶⁹ SNOMED-CT

⁷⁰ SNOMED-CT via HPO

⁷¹ SNOMED-CT via Orphanet

⁷² TGDB

⁷³ Tocris

⁷⁴ UMLS

⁷⁵ UMLS via Orphanet

⁷⁶ UniProtKB/Swiss-Prot

⁷⁷ Wikipedia