MCID: ACQ009
MIFTS: 35

Acquired Metabolic Disease

Categories: Metabolic diseases

Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease 12 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0060158

Summaries for Acquired Metabolic Disease

Disease Ontology : 12 A disease of metabolism that has _material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to hyperuricemia and hyperprolactinemia. An important gene associated with Acquired Metabolic Disease is INS (Insulin), and among its related pathways/superpathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. and Developmental Biology. Affiliated tissues include heart, liver and kidney, and related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 hyperuricemia 32.5 CRP INS REN
2 hyperprolactinemia 11.0
3 mineral metabolism disease 11.0
4 metabolic acidosis 11.0
5 amyloidosis 11.0
6 severe nonproliferative diabetic retinopathy 10.7 ALB INS
7 scleredema adultorum 10.7 INS PTH
8 idiopathic recurrent pericarditis 10.7 ADIPOQ LEP
9 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.7 IGF1 INS
10 benign essential hypertension 10.7 ALB REN
11 generalized atherosclerosis 10.7 ACE CRP
12 kidney papillary necrosis 10.7 ALB REN
13 hyperinsulinemic hypoglycemia, familial, 7 10.7 GCG INS
14 secondary adrenal insufficiency 10.7 IGF1 INS
15 renal artery obstruction 10.7 ACE REN
16 cold agglutinin disease 10.7 CRP IL6
17 skin sarcoidosis 10.7 ACE TNF
18 uveoparotid fever 10.7 ACE TNF
19 nonalcoholic fatty liver disease 10.7 ADIPOQ INS LEP
20 drug reaction with eosinophilia and systemic symptoms 10.7 CRP TNF
21 acute adrenal insufficiency 10.7 IL6 REN
22 angioimmunoblastic lymphadenopathy with dysproteinemia 10.7 IL6 TNF
23 subacute cutaneous lupus erythematosus 10.7 ACE TNF
24 leukomalacia 10.7 IL6 TNF
25 hyperthyroidism 10.7 GHRL INS LEP
26 aortic valve disease 2 10.7 ACE CRP REN
27 eating disorder 10.7 ADIPOQ GHRL LEP
28 acromegaly 10.7 GHRL IGF1 INS
29 membranous nephropathy 10.7 ACE ALB TNF
30 bronchitis 10.7 ALB CRP TNF
31 otitis media 10.7 ALB IL6 TNF
32 trypanosomiasis 10.7 ALB IL6 TNF
33 chlamydia 10.7 CRP IL6 TNF
34 gastrointestinal system cancer 10.7 ALB IL6 TNF
35 bronchiolitis 10.7 CRP IL6 TNF
36 synovitis 10.7 CRP IL6 TNF
37 acquired immunodeficiency syndrome 10.7 ALB IL6 TNF
38 purpura 10.7 CRP IL6 TNF
39 insulinoma 10.7 GCG IAPP INS
40 bone inflammation disease 10.7 CRP IL6 TNF
41 mouth disease 10.7 CRP IL6 TNF
42 spondylitis 10.7 CRP IL6 TNF
43 chagas disease 10.7 ACE IL6 TNF
44 juvenile rheumatoid arthritis 10.7 CRP IL6 TNF
45 periodontitis 10.7 CRP IL6 TNF
46 lipodystrophy, familial partial, type 1 10.7 INS LEP PPARG
47 monocytic leukemia 10.7 IL6 PPARG TNF
48 abdominal obesity-metabolic syndrome quantitative trait locus 2 10.7 INS LEP SLC2A4
49 reproductive system disease 10.7 IGF1 IL6 TNF
50 obesity-hypoventilation syndrome 10.7 ADIPOQ IL6 LEP

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:



Diseases related to Acquired Metabolic Disease

Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

47 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ACE ADIPOQ ALB CRP DPP4 GHRL
2 cardiovascular system MP:0005385 10.35 ACE ADIPOQ CRP IGF1 IL6 INS
3 growth/size/body region MP:0005378 10.35 ACE ADIPOQ DPP4 IAPP IGF1 IL6
4 endocrine/exocrine gland MP:0005379 10.34 ACE ADIPOQ ALB DPP4 GHRL IGF1
5 adipose tissue MP:0005375 10.33 ACE ADIPOQ GHRL IGF1 IL6 INS
6 immune system MP:0005387 10.28 ACE ADIPOQ CRP IAPP IGF1 IL6
7 cellular MP:0005384 10.26 ADIPOQ ALB IGF1 IL6 INS IRS1
8 hematopoietic system MP:0005397 10.23 ACE ADIPOQ IAPP IGF1 IL6 INS
9 mortality/aging MP:0010768 10.13 ACE ADIPOQ ALB IGF1 IL6 INS
10 digestive/alimentary MP:0005381 10.11 ALB GHRL IL6 INS LEP SLC2A4
11 liver/biliary system MP:0005370 10.07 ACE ADIPOQ ALB IL6 INS IRS1
12 muscle MP:0005369 10 ADIPOQ ALB IGF1 IL6 INS IRS1
13 neoplasm MP:0002006 9.76 ACE ADIPOQ ALB IGF1 IL6 LEP
14 renal/urinary system MP:0005367 9.65 ACE ADIPOQ ALB IGF1 IL6 INS
15 skeleton MP:0005390 9.36 ADIPOQ IAPP IGF1 IL6 INS IRS1

Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

Genetic Tests for Acquired Metabolic Disease

Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

42
Heart, Liver, Kidney, Bone, Pancreas, Lung, Lymph Node

Publications for Acquired Metabolic Disease

Variations for Acquired Metabolic Disease

Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 ADIPOQ GCG IL6 INS IRS1 LEP
2
Show member pathways
13.44 ADIPOQ IAPP INS IRS1 LEP PPARG
3
Show member pathways
13 ACE IGF1 IL6 INS IRS1 REN
4
Show member pathways
12.7 ADIPOQ IL6 INS IRS1 LEP SLC2A4
5 12.4 ADIPOQ GCG INS IRS1 PPARG SLC2A4
6
Show member pathways
12.29 ALB CRP IL6 INS TNF
8
Show member pathways
12.22 ADIPOQ IGF1 INS IRS1 LEP PPARG
9
Show member pathways
12.16 ACE IGF1 IL6 TNF
10
Show member pathways
12.14 INS IRS1 LEP SLC2A4
11
Show member pathways
12.09 ADIPOQ IGF1 INS IRS1 PPARG
12
Show member pathways
12.03 IGF1 IL6 INS IRS1 SLC2A4
13
Show member pathways
12.02 ACE DPP4 GCG GHRL IGF1 INS
14 12 ALB IGF1 IL6 INS
15
Show member pathways
11.87 IL6 INS IRS1 SLC2A4 TNF
16
Show member pathways
11.78 ADIPOQ INS IRS1 SLC2A4 TNF
17 11.73 ADIPOQ IGF1 IL6 INS IRS1 LEP
18 11.68 IGF1 IL6 PPARG TNF
19 11.61 IGF1 IL6 TNF
20 11.56 ADIPOQ IRS1 LEP SLC2A4 TNF
21
Show member pathways
11.55 DPP4 GCG LEP
22 11.51 IRS1 LEP SLC2A4
23 11.47 INS IRS1 LEP
24 11.45 IGF1 IL6 INS
25 11.41 IGF1 IL6 PTH TNF
26 11.33 IGF1 INS IRS1
27 11.14 ADIPOQ LEP PPARG
28 10.99 CRP IL6 TNF
29 10.51 ADIPOQ IL6 IRS1 LEP PPARG SLC2A4

GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 ACE ADIPOQ ALB CRP DPP4 GCG
2 endoplasmic reticulum lumen GO:0005788 9.55 ALB GCG GHRL IL6 INS
3 extracellular space GO:0005615 9.47 ACE ADIPOQ ALB CRP GCG GHRL

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 41)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.96 ALB IAPP IGF1 IL6 INS
2 response to ethanol GO:0045471 9.88 ADIPOQ LEP PTH SLC2A4
3 positive regulation of protein kinase B signaling GO:0051897 9.88 IAPP INS IRS1 LEP TNF
4 cellular response to insulin stimulus GO:0032869 9.87 ADIPOQ IRS1 PPARG SLC2A4
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.85 ADIPOQ IGF1 IL6
6 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.85 GCG IL6 TNF
7 response to nutrient GO:0007584 9.85 ADIPOQ LEP PPARG
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.83 IGF1 IL6 LEP
9 response to glucocorticoid GO:0051384 9.83 ADIPOQ IL6 TNF
10 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.83 IGF1 INS LEP TNF
11 positive regulation of protein kinase activity GO:0045860 9.81 ADIPOQ GCG TNF
12 regulation of insulin secretion GO:0050796 9.81 DPP4 GCG LEP TNF
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.8 IGF1 IL6 TNF
14 regulation of blood pressure GO:0008217 9.8 ACE LEP PPARG REN
15 positive regulation of MAPK cascade GO:0043410 9.8 IAPP IGF1 IL6 INS LEP
16 hormone-mediated signaling pathway GO:0009755 9.79 GHRL PPARG REN
17 negative regulation of fat cell differentiation GO:0045599 9.79 ADIPOQ IL6 TNF
18 acute-phase response GO:0006953 9.77 CRP IL6 INS
19 glucose metabolic process GO:0006006 9.77 ADIPOQ GHRL INS LEP TNF
20 response to nutrient levels GO:0031667 9.73 ADIPOQ GHRL LEP PTH
21 glucose homeostasis GO:0042593 9.73 ADIPOQ INS IRS1 LEP PPARG SLC2A4
22 glucose transmembrane transport GO:1904659 9.72 SLC2A4 SLC5A2 SLC5A4
23 positive regulation of insulin receptor signaling pathway GO:0046628 9.71 INS IRS1 LEP
24 negative regulation of bone resorption GO:0045779 9.68 IAPP IL6
25 regulation of protein secretion GO:0050708 9.68 INS TNF
26 angiotensin maturation GO:0002003 9.67 ACE REN
27 adult feeding behavior GO:0008343 9.67 GHRL LEP
28 negative regulation of blood vessel diameter GO:0097756 9.66 CRP INS
29 positive regulation of protein kinase A signaling GO:0010739 9.66 ADIPOQ IAPP
30 neutrophil mediated immunity GO:0002446 9.65 ACE IL6
31 negative regulation of acute inflammatory response GO:0002674 9.64 INS PPARG
32 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.63 ADIPOQ CRP PPARG
33 positive regulation of neuroinflammatory response GO:0150078 9.62 IL6 TNF
34 positive regulation of glycogen biosynthetic process GO:0045725 9.62 IGF1 INS IRS1 PTH
35 bone mineralization involved in bone maturation GO:0035630 9.61 IGF1 LEP
36 negative regulation of lipid storage GO:0010888 9.46 CRP IL6 LEP TNF
37 positive regulation of glucose import GO:0046326 9.35 ADIPOQ IGF1 INS IRS1 PTH
38 regulation of signaling receptor activity GO:0010469 9.32 ADIPOQ GCG GHRL IAPP IGF1 IL6
39 negative regulation of apoptotic process GO:0043066 10.08 ALB GCG GHRL IGF1 IL6 LEP
40 positive regulation of cell proliferation GO:0008284 10.06 DPP4 IGF1 IL6 INS IRS1 LEP
41 positive regulation of gene expression GO:0010628 10.04 CRP IGF1 IL6 INS TNF

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.81 ADIPOQ ALB CRP DPP4 GCG IAPP
2 signaling receptor binding GO:0005102 9.73 ADIPOQ DPP4 GCG IAPP LEP REN
3 drug binding GO:0008144 9.58 ACE ALB PPARG
4 insulin receptor binding GO:0005158 9.5 IGF1 INS IRS1
5 peptide hormone receptor binding GO:0051428 9.43 LEP PTH
6 glucose:sodium symporter activity GO:0005412 9.37 SLC5A2 SLC5A4
7 insulin-like growth factor receptor binding GO:0005159 9.26 IGF1 INS IRS1 REN
8 hormone activity GO:0005179 9.23 ADIPOQ GCG GHRL IAPP IGF1 INS

Sources for Acquired Metabolic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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