Acquired Metabolic Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease ¹¹ ¹⁴ ¹⁶

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases Genetic diseases
Anatomical: Endocrine diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:0060158

EFO ¹⁶ EFO_1000639

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Summaries for Acquired Metabolic Disease

Disease Ontology: ¹¹ A disease of metabolism that has material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary: Acquired Metabolic Disease is related to mineral metabolism disease and hyperprolactinemia. An important gene associated with Acquired Metabolic Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Adipogenesis and Mesenchymal Stem Cells and Lineage-specific Markers. Affiliated tissues include liver, and related phenotypes are immune system and hematopoietic system

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Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder

Metabolic Disease Due to Other Fatty Acid Oxidation Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 471)

#	Related Disease	Score	Top Affiliating Genes
1	mineral metabolism disease	32.4	INS IL6 H2AC18
2	hyperprolactinemia	11.0
3	metabolic acidosis	11.0
4	hyperuricemia	11.0
5	carotenemia	11.0
6	vascular disease	10.6	MIR21 MIR199A1 MIR126 LEP INS IL6
7	gastrointestinal system benign neoplasm	10.6	SERPINA3 MIR21 MIR199A1 MIR17 MIR142 INS
8	lipid metabolism disorder	10.6	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR126
9	lung disease	10.6	SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR126
10	bacterial infectious disease	10.6	SERPINA3 MIR21 MIR155 IL6 H2AC18 CCR6
11	malignant ovarian surface epithelial-stromal neoplasm	10.6	SERPINA3 MIR34A MIR27A MIR21 MIR199A1 MIR17
12	respiratory failure	10.6	SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR142
13	extrinsic cardiomyopathy	10.6	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR142
14	myopathy	10.6	SERPINA3 MIR221 MIR21 MIR199A1 MIR142 MIR140
15	pulmonary disease, chronic obstructive	10.6	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR142
16	thyroid gland disease	10.6	MIR221 MIR199A1 MIR17 MIR142 LEP INS
17	bile duct adenocarcinoma	10.6	SERPINA3 MIR29A MIR221 MIR21 MIR199A1 MIR17
18	mature b-cell neoplasm	10.6	MIR199A1 MIR17 MIR155 MIR142 MIR140 MIR126
19	heart conduction disease	10.6	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR142
20	muscle tissue disease	10.6	SERPINA3 MIR221 MIR21 MIR199A1 MIR142 MIR140
21	chromosomal disease	10.6	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR155
22	autonomic nervous system neoplasm	10.6	MIR34A MIR29A MIR27A MIR21 MIR199A1 MIR17
23	non-alcoholic steatohepatitis	10.6	MIR34A MIR21 MIR199A1 MIR142 MIR122 LEP
24	autoimmune disease of gastrointestinal tract	10.6	SERPINA3 MIR223 MIR21 MIR199A1 MIR142 MIR126
25	interstitial lung disease	10.6	SERPINA3 MIR29A MIR223 MIR21 MIR199A1 MIR155
26	spinal cord disease	10.6	SERPINA3 MIR29A MIR199A1 MIR155 MIR142 MIR126
27	primary bacterial infectious disease	10.6	SERPINA3 MIR223 MIR21 MIR155 MIR142 MIR126
28	colonic benign neoplasm	10.6	SERPINA3 MIR21 MIR199A1 INS IL6 H2AC18
29	peripheral nervous system neoplasm	10.6	SERPINA3 MIR34A MIR29A MIR27A MIR21 MIR199A1
30	intrinsic cardiomyopathy	10.6	SERPINA3 MIR27A MIR223 MIR21 MIR199A1 MIR17
31	heart valve disease	10.6	SERPINA3 MIR34A MIR21 MIR199A1 MIR17 MIR142
32	alcohol use disorder	10.6	SERPINA3 MIR29A MIR199A1 INS IL6 H2AC18
33	aortic aneurysm, familial abdominal, 1	10.6	SERPINA3 MIR21 MIR199A1 MIR126 MIR122 IL6
34	muscular disease	10.6	SERPINA3 MIR221 MIR21 MIR199A1 MIR17 MIR142
35	mature t-cell and nk-cell lymphoma	10.6	MIR21 MIR199A1 MIR17 MIR155 H2AC18 CCR6
36	biliary tract cancer	10.6	MIR29A MIR221 MIR21 MIR199A1 MIR17 MIR142
37	retinal vascular disease	10.6	SERPINA3 MIR27A MIR223 MIR21 MIR199A1 MIR17
38	physical disorder	10.6	SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR140
39	autoimmune disease of skin and connective tissue	10.6	SERPINA3 MIR223 MIR21 MIR17 MIR155 MIR142
40	placenta disease	10.6	SERPINA3 MIR223 MIR199A1 INS IL6 H2AC18
41	nasopharyngeal disease	10.6	MIR27A MIR223 MIR21 MIR199A1 MIR17 MIR155
42	aortic valve disease 2	10.6	SERPINA3 MIR34A MIR21 MIR199A1 MIR17 MIR126
43	intestinal benign neoplasm	10.6	SERPINA3 MIR21 MIR199A1 MIR17 MIR142 IL6
44	bone sarcoma	10.6	SERPINA3 MIR27A MIR223 MIR199A1 MIR17 MIR142
45	mouth disease	10.6	SERPINA3 MIR221 MIR21 MIR199A1 MIR17 MIR155
46	substance abuse	10.6	SERPINA3 MIR199A1 INS IL6 H2AC18 CCR6
47	peripheral t-cell lymphoma	10.6	MIR21 MIR199A1 MIR17 MIR155 H2AC18 CCR6
48	autoimmune disease of endocrine system	10.6	MIR21 MIR142 LEP INS IL6 H2AC18
49	malignant exocrine pancreas neoplasm	10.6	SERPINA3 MIR34A MIR223 MIR221 MIR21 MIR199A1
50	peripheral artery disease	10.6	MIR21 MIR199A1 MIR17 MIR126 INS IL6

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:

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Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.73	ADIPOQ CCR6 IL6 INS LEP MIR122
2	hematopoietic system	MP:0005397	9.4	ADIPOQ CCR6 IL6 INS LEP MIR122

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Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials, NIH Clinical Center for Acquired Metabolic Disease

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Genetic Tests for Acquired Metabolic Disease

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Anatomical Context for Acquired Metabolic Disease

Organs/tissues related to Acquired Metabolic Disease:

MalaCards : Liver

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Publications for Acquired Metabolic Disease

Articles related to Acquired Metabolic Disease:

#	Title	Authors	PMID	Year
1	Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates. ⁶²	Ullah R...Fu J	30745819	2019
2	Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China. ⁶²	Guo M...Liu X	25688884	2015
3	[Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. ⁶²	Fraenkel E...Feher J	17452309	2007

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Genes for Acquired Metabolic Disease

Genes related to Acquired Metabolic Disease (0 elite genes):

(show top 50) (show all 107)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MIR199A1	MicroRNA 199a-1	RNA Gene	13.55	DISEASES inferred ¹⁴ ¹⁴ ¹⁴
2	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	11.49	DISEASES inferred ¹⁴ ¹⁴
3	H2AC18	H2A Clustered Histone 18	Protein Coding	11.45	DISEASES inferred ¹⁴ ¹⁴
4	MIR21	MicroRNA 21	RNA Gene	11.09	DISEASES inferred ¹⁴ ¹⁴
5	INS	Insulin	Protein Coding	10.97	DISEASES inferred ¹⁴
6	LEP	Leptin	Protein Coding	10.7	DISEASES inferred ¹⁴
7	MIR126	MicroRNA 126	RNA Gene	10.66	DISEASES inferred ¹⁴ ¹⁴
8	SERPINA3	Serpin Family A Member 3	Protein Coding	10.62	DISEASES inferred ¹⁴ ¹⁴
9	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	10.22	DISEASES inferred ¹⁴
10	MIR29A	MicroRNA 29a	RNA Gene	10.03	DISEASES inferred ¹⁴ ¹⁴
11	MIR17	MicroRNA 17	RNA Gene	10.02	DISEASES inferred ¹⁴ ¹⁴
12	MIR140	MicroRNA 140	RNA Gene	10	DISEASES inferred ¹⁴ ¹⁴
13	MIR155	MicroRNA 155	RNA Gene	10	DISEASES inferred ¹⁴ ¹⁴
14	MIR122	MicroRNA 122	RNA Gene	9.98	DISEASES inferred ¹⁴ ¹⁴
15	MIR34A	MicroRNA 34a	RNA Gene	9.98	DISEASES inferred ¹⁴ ¹⁴
16	MIR223	MicroRNA 223	RNA Gene	9.81	DISEASES inferred ¹⁴ ¹⁴
17	IL6	Interleukin 6	Protein Coding	9.79	DISEASES inferred ¹⁴
18	MIR142	MicroRNA 142	RNA Gene	9.76	DISEASES inferred ¹⁴ ¹⁴
19	MIR221	MicroRNA 221	RNA Gene	9.69	DISEASES inferred ¹⁴ ¹⁴
20	MIR27A	MicroRNA 27a	RNA Gene	9.68	DISEASES inferred ¹⁴ ¹⁴
21	CRP	C-Reactive Protein	Protein Coding	9.68	DISEASES inferred ¹⁴
22	MIR146A	MicroRNA 146a	RNA Gene	9.67	DISEASES inferred ¹⁴ ¹⁴
23	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	9.61	DISEASES inferred ¹⁴
24	MIR143	MicroRNA 143	RNA Gene	9.58	DISEASES inferred ¹⁴ ¹⁴
25	MIR423	MicroRNA 423	RNA Gene	9.56	DISEASES inferred ¹⁴ ¹⁴
26	PTH	Parathyroid Hormone	Protein Coding	9.55	DISEASES inferred ¹⁴
27	TNF	Tumor Necrosis Factor	Protein Coding	9.46	DISEASES inferred ¹⁴
28	UCP1	Uncoupling Protein 1	Protein Coding	9.42	DISEASES inferred ¹⁴
29	MIR210	MicroRNA 210	RNA Gene	9.4	DISEASES inferred ¹⁴ ¹⁴
30	MIR103A1	MicroRNA 103a-1	RNA Gene	9.4	DISEASES inferred ¹⁴ ¹⁴
31	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	9.39	DISEASES inferred ¹⁴
32	GCG	Glucagon	Protein Coding	9.38	DISEASES inferred ¹⁴
33	MIR483	MicroRNA 483	RNA Gene	9.37	DISEASES inferred ¹⁴ ¹⁴
34	MIR22	MicroRNA 22	RNA Gene	9.36	DISEASES inferred ¹⁴ ¹⁴
35	PRODH	Proline Dehydrogenase 1	Protein Coding	9.33	DISEASES inferred ¹⁴ ¹⁴
36	ALB	Albumin	Protein Coding	9.33	DISEASES inferred ¹⁴
37	MIR33A	MicroRNA 33a	RNA Gene	9.26	DISEASES inferred ¹⁴ ¹⁴
38	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	9.25	DISEASES inferred ¹⁴ ¹⁴
39	MIR378A	MicroRNA 378a	RNA Gene	9.22	DISEASES inferred ¹⁴ ¹⁴
40	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	9.19	DISEASES inferred ¹⁴ ¹⁴
41	PPARA	Peroxisome Proliferator Activated Receptor Alpha	Protein Coding	9.18	DISEASES inferred ¹⁴
42	LEPR	Leptin Receptor	Protein Coding	9.18	DISEASES inferred ¹⁴
43	RETN	Resistin	Protein Coding	9.17	DISEASES inferred ¹⁴
44	IL1B	Interleukin 1 Beta	Protein Coding	9.15	DISEASES inferred ¹⁴
45	MIR144	MicroRNA 144	RNA Gene	9.14	DISEASES inferred ¹⁴ ¹⁴
46	REN	Renin	Protein Coding	9.12	DISEASES inferred ¹⁴
47	MIR486-1	MicroRNA 486-1	RNA Gene	9.11	DISEASES inferred ¹⁴ ¹⁴
48	MIR342	MicroRNA 342	RNA Gene	9.09	DISEASES inferred ¹⁴ ¹⁴
49	MIR23A	MicroRNA 23a	RNA Gene	9.08	DISEASES inferred ¹⁴ ¹⁴
50	MIR196A1	MicroRNA 196a-1	RNA Gene	9.04	DISEASES inferred ¹⁴ ¹⁴

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Variations for Acquired Metabolic Disease

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Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

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Pathways for Acquired Metabolic Disease

Pathways directly related to Acquired Metabolic Disease:

#	Pathway	Source
1	Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)	Reactome ⁶⁶

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Adipogenesis ⁷⁴	11.85	LEP INS IL6 ADIPOQ
2	Mesenchymal Stem Cells and Lineage-specific Markers ⁶⁵	11.68	LEP INS IL6 ADIPOQ
3	Cell differentiation - expanded index ⁷⁴ Show member pathways Cell differentiation - index ⁷⁴	11.45	MIR223 MIR221 MIR199A1 MIR17 MIR155
4	Hepatitis C and hepatocellular carcinoma ⁷⁴	11.37	MIR34A MIR155 IL6
5	Interactions between immune cells and microRNAs in tumor microenvironment ⁷⁴	11.3	MIR34A MIR29A MIR27A MIR21
6	miRNAs involved in DNA damage response ⁷⁴	11.26	MIR29A MIR27A MIR223 MIR221 MIR21 MIR17
7	Nonalcoholic fatty liver disease ⁷⁴	11.22	LEP INS IL6 ADIPOQ
8	Transcription factor regulation in adipogenesis ⁷⁴	10.89	LEP IL6 ADIPOQ
9	miRNAs involvement in the immune response in sepsis ⁷⁴	10.89	MIR21 MIR199A1 MIR155 MIR126 MIR122 IL6

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GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	10.18	SERPINA3 MIR29A MIR27A MIR223 MIR221 MIR21
2	RISC complex	GO:0016442	9.7	MIR29A MIR27A MIR223 MIR221 MIR21 MIR199A1
3	extracellular vesicle	GO:1903561	9.56	MIR122 MIR126 MIR17 MIR21 MIR221 MIR27A

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 36)

#	Name	GO ID	Score	Top Affiliating Genes
1	glucose homeostasis	GO:0042593	10.21	LEP INS IL6 ADIPOQ
2	positive regulation of apoptotic process	GO:0043065	10.14	MIR29A MIR27A MIR221 MIR21 IL6
3	positive regulation of gene expression	GO:0010628	10.14	MIR34A MIR29A MIR27A MIR223 MIR21 MIR17
4	response to activity	GO:0014823	10.13	LEP IL6 ADIPOQ
5	acute-phase response	GO:0006953	10.11	SERPINA3 INS IL6
6	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	10.06	MIR21 MIR126 LEP INS
7	cellular response to lipopolysaccharide	GO:0071222	10.05	MIR223 MIR21 MIR17 MIR140 IL6
8	regulation of angiogenesis	GO:0045765	10.03	IL6 LEP MIR199A1
9	negative regulation of cell migration	GO:0030336	10.03	MIR34A MIR29A MIR21 MIR126 ADIPOQ
10	positive regulation of glucose import	GO:0046326	10.02	ADIPOQ INS MIR223
11	positive regulation of receptor signaling pathway via JAK-STAT	GO:0046427	10.02	MIR221 LEP IL6
12	negative regulation of inflammatory response	GO:0050728	9.98	ADIPOQ MIR126 MIR142 MIR199A1 MIR221 MIR223
13	positive regulation of protein kinase B signaling	GO:0051897	9.97	INS LEP MIR126 MIR199A1 MIR21 MIR221
14	positive regulation of epithelial to mesenchymal transition	GO:0010718	9.96	MIR221 MIR21 IL6
15	cellular response to hypoxia	GO:0071456	9.94	MIR34A MIR17 MIR140 MIR126
16	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.9	MIR21 MIR17 IL6
17	negative regulation of vascular associated smooth muscle cell proliferation	GO:1904706	9.89	MIR34A MIR223 MIR140 ADIPOQ
18	negative regulation of low-density lipoprotein receptor activity	GO:1905598	9.85	MIR27A ADIPOQ
19	negative regulation of gene expression	GO:0010629	9.85	MIR34A MIR29A MIR27A MIR21 MIR199A1 MIR17
20	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.81	MIR27A MIR221 MIR21 MIR17
21	negative regulation of interleukin-1-mediated signaling pathway	GO:2000660	9.78	MIR27A MIR21 IL6
22	positive regulation of vascular endothelial cell proliferation	GO:1905564	9.76	MIR29A MIR27A MIR21 MIR126
23	negative regulation of sprouting angiogenesis	GO:1903671	9.74	MIR34A MIR221 MIR17
24	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	9.73	MIR29A MIR27A MIR221 MIR21 MIR17 MIR126
25	miRNA-mediated gene silencing by mRNA destabilization	GO:0035279	9.72	MIR27A MIR223 MIR140
26	positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	GO:1903589	9.71	MIR126 MIR21 MIR27A
27	negative regulation of low-density lipoprotein particle clearance	GO:0010989	9.7	MIR27A MIR199A1 MIR17
28	positive regulation of connective tissue replacement	GO:1905205	9.67	MIR34A MIR199A1
29	negative regulation of vascular endothelial growth factor production	GO:1904046	9.67	MIR34A MIR199A1 MIR17 MIR140
30	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.65	MIR17 MIR199A1
31	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.65	MIR21 MIR17
32	miRNA-mediated gene silencing	GO:0035195	9.64	MIR34A MIR29A MIR27A MIR223 MIR221 MIR21
33	positive regulation of metalloendopeptidase activity	GO:1904685	9.63	MIR21 MIR17
34	negative regulation of BMP secretion	GO:2001285	9.61	MIR17 MIR140
35	negative regulation of interleukin-21 production	GO:0032705	9.59	MIR21 MIR221
36	negative regulation of vascular associated smooth muscle cell migration	GO:1904753	9.43	ADIPOQ MIR140 MIR21 MIR223 MIR34A

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.7	MIR34A MIR29A MIR27A MIR223 MIR21 MIR199A1
2	mRNA base-pairing translational repressor activity	GO:1903231	9.4	MIR34A MIR29A MIR27A MIR223 MIR221 MIR21

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Sources for Acquired Metabolic Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

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⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

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¹⁵ DrugBank

¹⁶ EFO

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¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

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⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

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⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ACQ009 MIFTS: 30	Acquired Metabolic Disease Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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