MCID: ACQ009
MIFTS: 32

Acquired Metabolic Disease

Categories: Metabolic diseases

Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060158

Summaries for Acquired Metabolic Disease

Disease Ontology : 12 A disease of metabolism that has _material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to hyperuricemia and obesity-hypoventilation syndrome. An important gene associated with Acquired Metabolic Disease is INS (Insulin), and among its related pathways/superpathways are Metabolism of proteins and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Related phenotypes are homeostasis/metabolism and cardiovascular system

Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 234)
# Related Disease Score Top Affiliating Genes
1 hyperuricemia 33.0 CRP INS REN
2 obesity-hypoventilation syndrome 11.4 ADIPOQ IL6 LEP
3 malignant otitis externa 11.4 CRP INS
4 fetal macrosomia 11.3 IGF1 INS LEP
5 familial partial lipodystrophy 11.3 INS LEP PPARG
6 burns 11.3 ALB INS TNF
7 hyporeninemic hypoaldosteronism 11.3 ACE REN
8 background diabetic retinopathy 11.3 ALB INS TLR9
9 orthostatic proteinuria 11.3 ACE ALB REN
10 nontuberculous mycobacterial lung disease 11.3 ADIPOQ LEP TNF
11 abdominal obesity-metabolic syndrome quantitative trait locus 2 11.3 CRP INS LEP SLC2A4
12 hypersensitivity reaction type iii disease 11.3 ALB CRP IL6
13 acute insulin response 11.3 CRP GCG INS
14 angina pectoris 11.3 ACE CRP IL6
15 idiopathic edema 11.3 ACE ADIPOQ INS PPARG
16 inherited metabolic disorder 11.3 ADIPOQ CRP INS LEP
17 anuria 11.3 ACE ALB REN
18 acquired generalized lipodystrophy 11.3 ADIPOQ LEP
19 tuberculous peritonitis 11.3 ALB CRP TNF
20 acute cystitis 11.3 ALB CRP IL6
21 nonalcoholic steatohepatitis 11.3 ADIPOQ INS LEP TNF
22 renal hypertension 11.3 ACE ALB REN
23 coronary heart disease 1 11.3 ACE ADIPOQ CRP INS
24 hepatorenal syndrome 11.3 ACE ALB REN
25 anovulation 11.3 IGF1 INS LEP
26 acute pyelonephritis 11.3 ALB CRP IL6
27 intermediate coronary syndrome 11.3 ACE CRP IL6
28 bladder disease 11.3 CRP IL6 TRPV1
29 burning mouth syndrome 11.3 IL6 TNF TRPV1
30 viral pneumonia 11.3 CRP IL6 TLR9
31 pleural disease 11.3 ALB CRP TNF
32 sleep disorder 11.3 CRP IL6 LEP
33 gestational diabetes 11.3 ADIPOQ INS LEP SLC2A4
34 microvascular complications of diabetes 3 11.3 ACE ALB INS REN
35 louse-borne relapsing fever 11.3 CRP IL6 TNF
36 posterior urethral valves 11.3 ACE IL6 TNF
37 nutritional deficiency disease 11.3 ALB CRP GHRL LEP
38 scorpion envenomation 11.3 IL6 TNF
39 hemorrhagic fever 11.3 ALB IL6 TNF
40 thyroid gland disease 11.3 IGF1 INS PTH
41 rosacea 11.3 IL6 TNF TRPV1
42 pulpitis 11.3 IL6 TNF TRPV1
43 peripheral artery disease 11.3 ACE CRP IL6
44 microvascular complications of diabetes 5 11.3 ACE ALB IGF1 INS
45 interstitial nephritis 11.3 ACE ALB CRP REN
46 severe pre-eclampsia 11.3 ADIPOQ ALB LEP
47 cold agglutinin disease 11.3 CRP IL6
48 intermittent claudication 11.3 ACE ALB CRP IL6
49 anca-associated vasculitis 11.3 GHRL IL6 TNF
50 hypertensive retinopathy 11.3 ACE ADIPOQ PSMD9 REN

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:



Diseases related to Acquired Metabolic Disease

Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 CRP DPP4 IL6 LEP GHRL IGF1
2 cardiovascular system MP:0005385 10.35 CRP ADIPOQ IL6 LEP ACE IGF1
3 cellular MP:0005384 10.34 IGF1 INS ADIPOQ IL6 LEP ALB
4 growth/size/body region MP:0005378 10.32 IGF1 INS DPP4 ADIPOQ IL6 LEP
5 endocrine/exocrine gland MP:0005379 10.31 ADIPOQ DPP4 IL6 GHRL LEP ALB
6 adipose tissue MP:0005375 10.3 ADIPOQ IL6 LEP GHRL IGF1 ACE
7 behavior/neurological MP:0005386 10.29 BACE1 INS GHRL ADIPOQ IL6 ACE
8 immune system MP:0005387 10.25 CRP ADIPOQ IL6 LEP ACE IGF1
9 hematopoietic system MP:0005397 10.2 IGF1 INS ADIPOQ IL6 ACE PPARG
10 digestive/alimentary MP:0005381 10.11 INS GHRL IL6 LEP ALB SLC2A4
11 mortality/aging MP:0010768 10.1 IGF1 INS ADIPOQ IL6 LEP ALB
12 integument MP:0010771 10.02 BACE1 IGF1 INS ADIPOQ IL6 LEP
13 liver/biliary system MP:0005370 10.02 ADIPOQ IL6 LEP ALB ACE INS
14 muscle MP:0005369 9.9 ADIPOQ IL6 LEP ALB BACE1 IGF1
15 neoplasm MP:0002006 9.61 ADIPOQ IL6 LEP ALB ACE IGF1
16 renal/urinary system MP:0005367 9.36 ADIPOQ IL6 LEP ALB ACE IGF1

Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

Genetic Tests for Acquired Metabolic Disease

Anatomical Context for Acquired Metabolic Disease

Publications for Acquired Metabolic Disease

Variations for Acquired Metabolic Disease

Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 26)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.73 ACE BACE1 DPP4 GCG GHRL IGF1
2
Show member pathways
13.49 ADIPOQ BACE1 GCG IL6 INS LEP
3
Show member pathways
12.82 ADIPOQ IL6 INS LEP SLC2A4 TNF
4 12.44 ADIPOQ GCG INS PPARG SLC2A4
5
Show member pathways
12.19 ALB CRP IL6 INS TNF
7
Show member pathways
12.15 ADIPOQ IGF1 INS LEP PPARG SLC2A4
8
Show member pathways
12.14 ACE IGF1 IL6 TNF
9
Show member pathways
12.06 ADIPOQ IGF1 INS PPARG
10
Show member pathways
12.02 ACE DPP4 GCG GHRL IGF1 INS
11
Show member pathways
12 IGF1 IL6 INS SLC2A4
12 11.96 ALB IGF1 IL6 INS
13
Show member pathways
11.85 IL6 INS SLC2A4 TNF
14
Show member pathways
11.76 ADIPOQ INS SLC2A4 TNF
15 11.68 ADIPOQ IGF1 IL6 INS LEP PPARG
16 11.67 IL6 TLR9 TNF
17 11.59 IGF1 IL6 TNF
18
Show member pathways
11.54 DPP4 GCG LEP
19 11.51 ADIPOQ LEP SLC2A4 TNF
20 11.46 IL6 TLR9 TNF
21 11.44 IGF1 IL6 INS
22 11.28 IGF1 IL6 PTH TNF
23 11.24 IL6 TLR9 TNF
24 11.07 ADIPOQ LEP PPARG
25 10.86 CRP IL6 TNF
26 10.44 ADIPOQ IL6 LEP PPARG SLC2A4 TNF

GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 ACE ADIPOQ ALB CRP DPP4 GCG
2 endoplasmic reticulum lumen GO:0005788 9.63 ALB BACE1 GCG GHRL IL6 INS
3 membrane raft GO:0045121 9.56 BACE1 DPP4 SLC2A4 TNF
4 extracellular space GO:0005615 9.47 ACE ADIPOQ ALB CRP GCG GHRL

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 47)
# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.97 ALB BACE1 IGF1 IL6 INS
2 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.92 IL6 INS TLR9 TNF
3 activation of MAPK activity GO:0000187 9.91 GHRL IGF1 INS TNF
4 response to ethanol GO:0045471 9.9 ADIPOQ LEP PTH SLC2A4
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.88 ADIPOQ IGF1 IL6 INS
6 cellular response to insulin stimulus GO:0032869 9.87 ADIPOQ PPARG SLC2A4
7 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.86 GCG IL6 TNF
8 response to nutrient GO:0007584 9.86 ADIPOQ LEP PPARG
9 response to glucose GO:0009749 9.86 ADIPOQ IGF1 INS
10 response to insulin GO:0032868 9.85 IGF1 INS LEP
11 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.84 IGF1 INS LEP
12 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.84 IGF1 IL6 LEP
13 regulation of blood pressure GO:0008217 9.84 ACE LEP PPARG REN
14 response to glucocorticoid GO:0051384 9.83 ADIPOQ IL6 TNF
15 positive regulation of protein kinase activity GO:0045860 9.83 ADIPOQ GCG TNF
16 positive regulation of MAPK cascade GO:0043410 9.83 IGF1 IL6 INS LEP TLR9
17 positive regulation of smooth muscle cell proliferation GO:0048661 9.82 IGF1 IL6 TNF
18 positive regulation of interleukin-6 production GO:0032755 9.81 IL6 TLR9 TNF
19 regulation of insulin secretion GO:0050796 9.81 DPP4 GCG LEP TNF
20 negative regulation of fat cell differentiation GO:0045599 9.8 ADIPOQ IL6 TNF
21 hormone-mediated signaling pathway GO:0009755 9.8 GHRL PPARG REN
22 response to organic substance GO:0010033 9.8 IGF1 INS PPARG REN TNF
23 acute-phase response GO:0006953 9.79 CRP IL6 INS
24 positive regulation of interleukin-8 production GO:0032757 9.77 ADIPOQ TLR9 TNF
25 positive regulation of chemokine production GO:0032722 9.74 IL6 TLR9 TNF
26 glucose homeostasis GO:0042593 9.73 ADIPOQ IGF1 INS LEP PPARG SLC2A4
27 positive regulation of insulin receptor signaling pathway GO:0046628 9.72 IGF1 INS LEP
28 glucose metabolic process GO:0006006 9.72 ADIPOQ GHRL INS LEP TNF
29 negative regulation of gluconeogenesis GO:0045721 9.7 ADIPOQ INS
30 positive regulation of glycogen biosynthetic process GO:0045725 9.7 IGF1 INS PTH
31 angiotensin maturation GO:0002003 9.69 ACE REN
32 negative regulation of glucose import GO:0046325 9.69 LEP TNF
33 adult feeding behavior GO:0008343 9.68 GHRL LEP
34 neutrophil mediated immunity GO:0002446 9.68 ACE IL6
35 negative regulation of blood vessel diameter GO:0097756 9.67 CRP INS
36 amyloid-beta metabolic process GO:0050435 9.67 ACE BACE1 REN
37 positive regulation of glucose import GO:0046326 9.67 ADIPOQ IGF1 INS PTH
38 negative regulation of acute inflammatory response GO:0002674 9.65 INS PPARG
39 bone mineralization involved in bone maturation GO:0035630 9.63 IGF1 LEP
40 negative regulation of macrophage derived foam cell differentiation GO:0010745 9.63 ADIPOQ CRP PPARG
41 regulation of signaling receptor activity GO:0010469 9.61 ADIPOQ GCG GHRL IGF1 IL6 INS
42 negative regulation of lipid storage GO:0010888 9.46 CRP IL6 LEP TNF
43 response to nutrient levels GO:0031667 9.1 ADIPOQ GHRL IGF1 INS LEP PTH
44 positive regulation of cell proliferation GO:0008284 10.1 DPP4 IGF1 IL6 INS LEP
45 inflammatory response GO:0006954 10.04 CRP IL6 TLR9 TNF TRPV1
46 positive regulation of gene expression GO:0010628 10.03 CRP IGF1 IL6 INS TLR9 TNF
47 negative regulation of apoptotic process GO:0043066 10.02 ALB GCG GHRL IGF1 IL6 INS

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.72 ADIPOQ DPP4 GCG LEP REN
2 endopeptidase activity GO:0004175 9.61 ACE BACE1 REN
3 identical protein binding GO:0042802 9.61 ADIPOQ ALB CRP DPP4 GCG INS
4 drug binding GO:0008144 9.54 ACE ALB PPARG
5 peptide hormone receptor binding GO:0051428 9.4 LEP PTH
6 insulin-like growth factor receptor binding GO:0005159 9.33 IGF1 INS REN
7 receptor activator activity GO:0030546 9.26 IGF1 INS
8 hormone activity GO:0005179 9.17 ADIPOQ GCG GHRL IGF1 INS LEP

Sources for Acquired Metabolic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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