MCID: ACQ009
MIFTS: 30

Acquired Metabolic Disease

Categories: Endocrine diseases, Genetic diseases, Metabolic diseases, Rare diseases
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Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease 11 14 16

Classifications:



External Ids:

Disease Ontology 11 DOID:0060158

Summaries for Acquired Metabolic Disease

Disease Ontology: 11 A disease of metabolism that has material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary: Acquired Metabolic Disease is related to mineral metabolism disease and hyperprolactinemia. An important gene associated with Acquired Metabolic Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Adipogenesis and Mesenchymal Stem Cells and Lineage-specific Markers. Affiliated tissues include liver, and related phenotypes are immune system and hematopoietic system

Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder Metabolic Disease Due to Other Fatty Acid Oxidation Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 471)
# Related Disease Score Top Affiliating Genes
1 mineral metabolism disease 32.4 INS IL6 H2AC18
2 hyperprolactinemia 11.0
3 metabolic acidosis 11.0
4 hyperuricemia 11.0
5 carotenemia 11.0
6 vascular disease 10.6 MIR21 MIR199A1 MIR126 LEP INS IL6
7 gastrointestinal system benign neoplasm 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 INS
8 lipid metabolism disorder 10.6 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR126
9 lung disease 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR126
10 bacterial infectious disease 10.6 SERPINA3 MIR21 MIR155 IL6 H2AC18 CCR6
11 malignant ovarian surface epithelial-stromal neoplasm 10.6 SERPINA3 MIR34A MIR27A MIR21 MIR199A1 MIR17
12 respiratory failure 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR142
13 extrinsic cardiomyopathy 10.6 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR142
14 myopathy 10.6 SERPINA3 MIR221 MIR21 MIR199A1 MIR142 MIR140
15 pulmonary disease, chronic obstructive 10.6 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR142
16 thyroid gland disease 10.6 MIR221 MIR199A1 MIR17 MIR142 LEP INS
17 bile duct adenocarcinoma 10.6 SERPINA3 MIR29A MIR221 MIR21 MIR199A1 MIR17
18 mature b-cell neoplasm 10.6 MIR199A1 MIR17 MIR155 MIR142 MIR140 MIR126
19 heart conduction disease 10.6 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR142
20 muscle tissue disease 10.6 SERPINA3 MIR221 MIR21 MIR199A1 MIR142 MIR140
21 chromosomal disease 10.6 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR155
22 autonomic nervous system neoplasm 10.6 MIR34A MIR29A MIR27A MIR21 MIR199A1 MIR17
23 non-alcoholic steatohepatitis 10.6 MIR34A MIR21 MIR199A1 MIR142 MIR122 LEP
24 autoimmune disease of gastrointestinal tract 10.6 SERPINA3 MIR223 MIR21 MIR199A1 MIR142 MIR126
25 interstitial lung disease 10.6 SERPINA3 MIR29A MIR223 MIR21 MIR199A1 MIR155
26 spinal cord disease 10.6 SERPINA3 MIR29A MIR199A1 MIR155 MIR142 MIR126
27 primary bacterial infectious disease 10.6 SERPINA3 MIR223 MIR21 MIR155 MIR142 MIR126
28 colonic benign neoplasm 10.6 SERPINA3 MIR21 MIR199A1 INS IL6 H2AC18
29 peripheral nervous system neoplasm 10.6 SERPINA3 MIR34A MIR29A MIR27A MIR21 MIR199A1
30 intrinsic cardiomyopathy 10.6 SERPINA3 MIR27A MIR223 MIR21 MIR199A1 MIR17
31 heart valve disease 10.6 SERPINA3 MIR34A MIR21 MIR199A1 MIR17 MIR142
32 alcohol use disorder 10.6 SERPINA3 MIR29A MIR199A1 INS IL6 H2AC18
33 aortic aneurysm, familial abdominal, 1 10.6 SERPINA3 MIR21 MIR199A1 MIR126 MIR122 IL6
34 muscular disease 10.6 SERPINA3 MIR221 MIR21 MIR199A1 MIR17 MIR142
35 mature t-cell and nk-cell lymphoma 10.6 MIR21 MIR199A1 MIR17 MIR155 H2AC18 CCR6
36 biliary tract cancer 10.6 MIR29A MIR221 MIR21 MIR199A1 MIR17 MIR142
37 retinal vascular disease 10.6 SERPINA3 MIR27A MIR223 MIR21 MIR199A1 MIR17
38 physical disorder 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR140
39 autoimmune disease of skin and connective tissue 10.6 SERPINA3 MIR223 MIR21 MIR17 MIR155 MIR142
40 placenta disease 10.6 SERPINA3 MIR223 MIR199A1 INS IL6 H2AC18
41 nasopharyngeal disease 10.6 MIR27A MIR223 MIR21 MIR199A1 MIR17 MIR155
42 aortic valve disease 2 10.6 SERPINA3 MIR34A MIR21 MIR199A1 MIR17 MIR126
43 intestinal benign neoplasm 10.6 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 IL6
44 bone sarcoma 10.6 SERPINA3 MIR27A MIR223 MIR199A1 MIR17 MIR142
45 mouth disease 10.6 SERPINA3 MIR221 MIR21 MIR199A1 MIR17 MIR155
46 substance abuse 10.6 SERPINA3 MIR199A1 INS IL6 H2AC18 CCR6
47 peripheral t-cell lymphoma 10.6 MIR21 MIR199A1 MIR17 MIR155 H2AC18 CCR6
48 autoimmune disease of endocrine system 10.6 MIR21 MIR142 LEP INS IL6 H2AC18
49 malignant exocrine pancreas neoplasm 10.6 SERPINA3 MIR34A MIR223 MIR221 MIR21 MIR199A1
50 peripheral artery disease 10.6 MIR21 MIR199A1 MIR17 MIR126 INS IL6

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:



Diseases related to Acquired Metabolic Disease

Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.73 ADIPOQ CCR6 IL6 INS LEP MIR122
2 hematopoietic system MP:0005397 9.4 ADIPOQ CCR6 IL6 INS LEP MIR122

Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials, NIH Clinical Center for Acquired Metabolic Disease

Genetic Tests for Acquired Metabolic Disease

Anatomical Context for Acquired Metabolic Disease

Organs/tissues related to Acquired Metabolic Disease:

MalaCards : Liver

Publications for Acquired Metabolic Disease

Articles related to Acquired Metabolic Disease:

# Title Authors PMID Year
1
Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates. 62
30745819 2019
2
Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China. 62
25688884 2015
3
[Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. 62
17452309 2007

Variations for Acquired Metabolic Disease

Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

Pathways for Acquired Metabolic Disease



Pathways directly related to Acquired Metabolic Disease:

# Pathway Source
1 Defective SLC22A12 causes renal hypouricemia 1 (RHUC1) Reactome 66

GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 10.18 SERPINA3 MIR29A MIR27A MIR223 MIR221 MIR21
2 RISC complex GO:0016442 9.7 MIR29A MIR27A MIR223 MIR221 MIR21 MIR199A1
3 extracellular vesicle GO:1903561 9.56 MIR122 MIR126 MIR17 MIR21 MIR221 MIR27A

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 glucose homeostasis GO:0042593 10.21 LEP INS IL6 ADIPOQ
2 positive regulation of apoptotic process GO:0043065 10.14 MIR29A MIR27A MIR221 MIR21 IL6
3 positive regulation of gene expression GO:0010628 10.14 MIR34A MIR29A MIR27A MIR223 MIR21 MIR17
4 response to activity GO:0014823 10.13 LEP IL6 ADIPOQ
5 acute-phase response GO:0006953 10.11 SERPINA3 INS IL6
6 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 10.06 MIR21 MIR126 LEP INS
7 cellular response to lipopolysaccharide GO:0071222 10.05 MIR223 MIR21 MIR17 MIR140 IL6
8 regulation of angiogenesis GO:0045765 10.03 IL6 LEP MIR199A1
9 negative regulation of cell migration GO:0030336 10.03 MIR34A MIR29A MIR21 MIR126 ADIPOQ
10 positive regulation of glucose import GO:0046326 10.02 ADIPOQ INS MIR223
11 positive regulation of receptor signaling pathway via JAK-STAT GO:0046427 10.02 MIR221 LEP IL6
12 negative regulation of inflammatory response GO:0050728 9.98 ADIPOQ MIR126 MIR142 MIR199A1 MIR221 MIR223
13 positive regulation of protein kinase B signaling GO:0051897 9.97 INS LEP MIR126 MIR199A1 MIR21 MIR221
14 positive regulation of epithelial to mesenchymal transition GO:0010718 9.96 MIR221 MIR21 IL6
15 cellular response to hypoxia GO:0071456 9.94 MIR34A MIR17 MIR140 MIR126
16 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.9 MIR21 MIR17 IL6
17 negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 9.89 MIR34A MIR223 MIR140 ADIPOQ
18 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.85 MIR27A ADIPOQ
19 negative regulation of gene expression GO:0010629 9.85 MIR34A MIR29A MIR27A MIR21 MIR199A1 MIR17
20 positive regulation of vascular associated smooth muscle cell proliferation GO:1904707 9.81 MIR27A MIR221 MIR21 MIR17
21 negative regulation of interleukin-1-mediated signaling pathway GO:2000660 9.78 MIR27A MIR21 IL6
22 positive regulation of vascular endothelial cell proliferation GO:1905564 9.76 MIR29A MIR27A MIR21 MIR126
23 negative regulation of sprouting angiogenesis GO:1903671 9.74 MIR34A MIR221 MIR17
24 miRNA-mediated gene silencing by inhibition of translation GO:0035278 9.73 MIR29A MIR27A MIR221 MIR21 MIR17 MIR126
25 miRNA-mediated gene silencing by mRNA destabilization GO:0035279 9.72 MIR27A MIR223 MIR140
26 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.71 MIR126 MIR21 MIR27A
27 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.7 MIR27A MIR199A1 MIR17
28 positive regulation of connective tissue replacement GO:1905205 9.67 MIR34A MIR199A1
29 negative regulation of vascular endothelial growth factor production GO:1904046 9.67 MIR34A MIR199A1 MIR17 MIR140
30 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.65 MIR17 MIR199A1
31 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.65 MIR21 MIR17
32 miRNA-mediated gene silencing GO:0035195 9.64 MIR34A MIR29A MIR27A MIR223 MIR221 MIR21
33 positive regulation of metalloendopeptidase activity GO:1904685 9.63 MIR21 MIR17
34 negative regulation of BMP secretion GO:2001285 9.61 MIR17 MIR140
35 negative regulation of interleukin-21 production GO:0032705 9.59 MIR21 MIR221
36 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.43 ADIPOQ MIR140 MIR21 MIR223 MIR34A

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.7 MIR34A MIR29A MIR27A MIR223 MIR21 MIR199A1
2 mRNA base-pairing translational repressor activity GO:1903231 9.4 MIR34A MIR29A MIR27A MIR223 MIR221 MIR21

Sources for Acquired Metabolic Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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