Acquired Metabolic Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACQ009 MIFTS: 28	Acquired Metabolic Disease Categories: Genetic diseases, Metabolic diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease ¹² ¹⁵ ¹⁷

Classifications:

MalaCards categories:
Global: Metabolic diseases Rare diseases Genetic diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060158

EFO ¹⁷ EFO_1000639

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Summaries for Acquired Metabolic Disease

Disease Ontology : ¹² A disease of metabolism that has material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to mineral metabolism disease and hyperuricemia. An important gene associated with Acquired Metabolic Disease is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways is MicroRNAs in cancer. Affiliated tissues include liver, bone and heart.

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Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder

Metabolic Disease Due to Other Fatty Acid Oxidation Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)

#	Related Disease	Score	Top Affiliating Genes
1	mineral metabolism disease	32.9	INS H2AC18 ALB
2	hyperuricemia	32.7	LEP INS ALB
3	hyperprolactinemia	11.1
4	metabolic acidosis	11.1
5	amyloidosis	11.1
6	prostate disease	11.0	SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR146A
7	connective tissue cancer	11.0	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR140
8	peripheral nervous system disease	11.0	SERPINA3 MIR21 MIR126 INS ICOSLG H2AC18
9	autosomal genetic disease	11.0	SERPINA3 MIR21 MIR199A1 MIR17 MIR140 MIR126
10	gonadal disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
11	bone inflammation disease	11.0	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR155
12	cervix disease	11.0	SERPINA3 MIR21 MIR199A1 MIR17 MIR146A MIR140
13	breast disease	11.0	SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
14	endocrine system disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
15	disease of mental health	11.0	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR140
16	bronchial disease	11.0	SERPINA3 MIR21 MIR17 MIR155 MIR140 MIR126
17	bone marrow cancer	11.0	MIR21 MIR199A1 MIR17 MIR155 MIR140 MIR126
18	inherited metabolic disorder	11.0	SERPINA3 MIR21 MIR199A1 MIR17 MIR126 LEP
19	nervous system disease	11.0	SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR155
20	gastrointestinal system benign neoplasm	11.0	SERPINA3 MIR21 MIR199A1 MIR17 INS H2AC18
21	thoracic cancer	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
22	eye disease	11.0	SERPINA3 MIR21 MIR199A1 MIR17 MIR140 MIR126
23	male reproductive system disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
24	stomach disease	11.0	SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR146A
25	reproductive system disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
26	autoimmune disease of musculoskeletal system	11.0	SERPINA3 MIR223 MIR21 MIR155 MIR146A MIR140
27	male reproductive organ cancer	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
28	connective tissue disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
29	gastrointestinal system cancer	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
30	immune system disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
31	hematologic cancer	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
32	female reproductive system disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
33	leukocyte disease	11.0	SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
34	cardiovascular system disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
35	cell type cancer	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
36	thyroid gland disease	11.0	MIR423 MIR21 MIR199A1 MIR17 MIR146A MIR140
37	uterine anomalies	11.0	SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR146A
38	respiratory system cancer	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
39	bladder disease	11.0	MIR423 MIR21 MIR199A1 MIR17 MIR146A MIR140
40	endocrine organ benign neoplasm	11.0	SERPINA3 MIR21 MIR199A1 MIR17 MIR126 INS
41	arteries, anomalies of	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
42	colonic disease	11.0	MIR423 MIR21 MIR199A1 MIR17 MIR155 MIR140
43	nervous system cancer	11.0	SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
44	diabetes mellitus, noninsulin-dependent	11.0	SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR146A
45	gastrointestinal system disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
46	intestinal disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
47	urinary system disease	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
48	upper respiratory tract disease	11.0	SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR140
49	leukemia, chronic lymphocytic	11.0	MIR423 MIR223 MIR21 MIR199A1 MIR17 MIR155
50	endocrine gland cancer	11.0	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:

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Symptoms & Phenotypes for Acquired Metabolic Disease

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Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

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Genetic Tests for Acquired Metabolic Disease

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Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

⁴⁰

Liver, Bone, Heart, Skin, Lung, Thyroid, B Cells

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Publications for Acquired Metabolic Disease

Articles related to Acquired Metabolic Disease:

#	Title	Authors	PMID	Year
1	Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates. ⁶¹	Ullah R...Fu J	30745819	2019
2	Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China. ⁶¹	Guo M...Liu X	25688884	2015
3	[Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. ⁶¹	Fraenkel E...Feher J	17452309	2007

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Genes for Acquired Metabolic Disease

Genes related to Acquired Metabolic Disease (0 elite genes):

(show top 50) (show all 111)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	H2AC18	H2A Clustered Histone 18	Protein Coding	12.54	DISEASES inferred ¹⁵ ¹⁵
2	CCR6	C-C Motif Chemokine Receptor 6	Protein Coding	12.48	DISEASES inferred ¹⁵ ¹⁵
3	INS	Insulin	Protein Coding	11.98	DISEASES inferred ¹⁵
4	MIR21	MicroRNA 21	RNA Gene	11.84	DISEASES inferred ¹⁵ ¹⁵
5	MIR126	MicroRNA 126	RNA Gene	11.74	DISEASES inferred ¹⁵ ¹⁵
6	SERPINA3	Serpin Family A Member 3	Protein Coding	11.58	DISEASES inferred ¹⁵ ¹⁵
7	ICOSLG	Inducible T Cell Costimulator Ligand	Protein Coding	11.57	DISEASES inferred ¹⁵ ¹⁵
8	MIR199A1	MicroRNA 199a-1	RNA Gene	10.99	DISEASES inferred ¹⁵ ¹⁵
9	MIR146A	MicroRNA 146a	RNA Gene	10.65	DISEASES inferred ¹⁵ ¹⁵
10	LEP	Leptin	Protein Coding	10.64	DISEASES inferred ¹⁵
11	MIR155	MicroRNA 155	RNA Gene	10.63	DISEASES inferred ¹⁵ ¹⁵
12	MIR17	MicroRNA 17	RNA Gene	10.6	DISEASES inferred ¹⁵ ¹⁵
13	MIR223	MicroRNA 223	RNA Gene	10.52	DISEASES inferred ¹⁵ ¹⁵
14	GCG	Glucagon	Protein Coding	10.44	DISEASES inferred ¹⁵
15	EPRS1	Glutamyl-Prolyl-TRNA Synthetase 1	Protein Coding	10.35	DISEASES inferred ¹⁵ ¹⁵
16	MIR140	MicroRNA 140	RNA Gene	10.34	DISEASES inferred ¹⁵ ¹⁵
17	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	10.31	DISEASES inferred ¹⁵
18	MIR103A1	MicroRNA 103a-1	RNA Gene	10.26	DISEASES inferred ¹⁵ ¹⁵
19	MIR423	MicroRNA 423	RNA Gene	10.24	DISEASES inferred ¹⁵ ¹⁵
20	ALB	Albumin	Protein Coding	10.2	DISEASES inferred ¹⁵
21	MIR142	MicroRNA 142	RNA Gene	10.19	DISEASES inferred ¹⁵ ¹⁵
22	PRODH	Proline Dehydrogenase 1	Protein Coding	10.17	DISEASES inferred ¹⁵ ¹⁵
23	CRP	C-Reactive Protein	Protein Coding	10.17	DISEASES inferred ¹⁵
24	MIR28	MicroRNA 28	RNA Gene	10.15	DISEASES inferred ¹⁵ ¹⁵
25	MIR29A	MicroRNA 29a	RNA Gene	10.05	DISEASES inferred ¹⁵ ¹⁵
26	MIR143	MicroRNA 143	RNA Gene	9.99	DISEASES inferred ¹⁵ ¹⁵
27	MIR222	MicroRNA 222	RNA Gene	9.95	DISEASES inferred ¹⁵ ¹⁵
28	IL6	Interleukin 6	Protein Coding	9.95	DISEASES inferred ¹⁵
29	MIR210	MicroRNA 210	RNA Gene	9.89	DISEASES inferred ¹⁵ ¹⁵
30	ACE	Angiotensin I Converting Enzyme	Protein Coding	9.84	DISEASES inferred ¹⁵
31	MIR483	MicroRNA 483	RNA Gene	9.84	DISEASES inferred ¹⁵ ¹⁵
32	MIR181A1	MicroRNA 181a-1	RNA Gene	9.81	DISEASES inferred ¹⁵ ¹⁵
33	MIR144	MicroRNA 144	RNA Gene	9.79	DISEASES inferred ¹⁵ ¹⁵
34	MIR9-1	MicroRNA 9-1	RNA Gene	9.79	DISEASES inferred ¹⁵ ¹⁵
35	MIR30A	MicroRNA 30a	RNA Gene	9.76	DISEASES inferred ¹⁵ ¹⁵
36	MIR486-1	MicroRNA 486-1	RNA Gene	9.73	DISEASES inferred ¹⁵ ¹⁵
37	CRYAA	Crystallin Alpha A	Protein Coding	9.73	DISEASES inferred ¹⁵ ¹⁵
38	MIR27A	MicroRNA 27a	RNA Gene	9.7	DISEASES inferred ¹⁵ ¹⁵
39	MIR196A1	MicroRNA 196a-1	RNA Gene	9.68	DISEASES inferred ¹⁵ ¹⁵
40	REN	Renin	Protein Coding	9.65	DISEASES inferred ¹⁵
41	DPP4	Dipeptidyl Peptidase 4	Protein Coding	9.64	DISEASES inferred ¹⁵
42	PTH	Parathyroid Hormone	Protein Coding	9.61	DISEASES inferred ¹⁵
43	TNF	Tumor Necrosis Factor	Protein Coding	9.59	DISEASES inferred ¹⁵
44	IGF1	Insulin Like Growth Factor 1	Protein Coding	9.57	DISEASES inferred ¹⁵
45	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	9.54	DISEASES inferred ¹⁵
46	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	9.51	DISEASES inferred ¹⁵
47	MIR22	MicroRNA 22	RNA Gene	9.51	DISEASES inferred ¹⁵ ¹⁵
48	MIR342	MicroRNA 342	RNA Gene	9.49	DISEASES inferred ¹⁵ ¹⁵
49	MIR146B	MicroRNA 146b	RNA Gene	9.47	DISEASES inferred ¹⁵ ¹⁵
50	BLOC1S1	Biogenesis Of Lysosomal Organelles Complex 1 Subunit 1	Protein Coding	9.45	DISEASES inferred ¹⁵ ¹⁵

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Variations for Acquired Metabolic Disease

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Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

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Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	MicroRNAs in cancer ³⁶	11.77	MIR423 MIR223 MIR21 MIR199A1 MIR17 MIR155

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GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular space	GO:0005615	9.53	SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 30)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of gene expression	GO:0010629	9.95	MIR146A MIR155 MIR17 MIR21
2	positive regulation of gene expression	GO:0010628	9.95	INS MIR140 MIR146A MIR155 MIR21 MIR223
3	cellular response to lipopolysaccharide	GO:0071222	9.88	MIR140 MIR146A MIR17 MIR21
4	cellular response to insulin stimulus	GO:0032869	9.82	ADIPOQ EPRS1 MIR103A1
5	positive regulation of inflammatory response	GO:0050729	9.8	MIR126 MIR155 MIR21
6	positive regulation of protein kinase B signaling	GO:0051897	9.8	INS LEP MIR126 MIR199A1 MIR21
7	glucose metabolic process	GO:0006006	9.77	ADIPOQ INS LEP
8	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.76	INS LEP MIR126 MIR21
9	negative regulation of inflammatory response	GO:0050728	9.72	ADIPOQ MIR126 MIR146A MIR155 MIR223
10	negative regulation of vascular smooth muscle cell proliferation	GO:1904706	9.71	ADIPOQ MIR140 MIR223
11	positive regulation of glucose import	GO:0046326	9.7	ADIPOQ INS MIR223
12	negative regulation of NIK/NF-kappaB signaling	GO:1901223	9.69	MIR146A MIR21 MIR223
13	positive regulation of activated T cell proliferation	GO:0042104	9.67	ICOSLG MIR155 MIR21
14	cellular response to hypoxia	GO:0071456	9.65	MIR126 MIR140 MIR146A MIR155 MIR17
15	positive regulation of connective tissue replacement	GO:1905205	9.64	MIR155 MIR199A1
16	negative regulation of toll-like receptor 4 signaling pathway	GO:0034144	9.63	MIR140 MIR146A
17	cellular response to oxidised low-density lipoprotein particle stimulus	GO:0140052	9.62	MIR146A MIR155
18	negative regulation of cartilage development	GO:0061037	9.62	LEP MIR21
19	positive regulation of metalloendopeptidase activity	GO:1904685	9.61	MIR17 MIR21
20	negative regulation of regulatory T cell differentiation	GO:0045590	9.61	MIR155 MIR21
21	negative regulation of low-density lipoprotein particle clearance	GO:0010989	9.61	MIR155 MIR17 MIR199A1
22	negative regulation of leukocyte adhesion to vascular endothelial cell	GO:1904995	9.59	MIR146A MIR155
23	negative regulation of vascular associated smooth muscle cell apoptotic process	GO:1905460	9.58	MIR17 MIR21
24	positive regulation of necroptotic process	GO:0060545	9.57	MIR103A1 MIR155
25	negative regulation of protein oligomerization	GO:0032460	9.56	ALB INS
26	negative regulation of necrotic cell death	GO:0060547	9.55	MIR155 MIR223
27	miRNA mediated inhibition of translation	GO:0035278	9.55	MIR103A1 MIR146A MIR155 MIR17 MIR21
28	positive regulation of cardiac muscle hypertrophy in response to stress	GO:1903244	9.54	MIR155 MIR17 MIR199A1
29	gene silencing by miRNA	GO:0035195	9.32	MIR103A1 MIR126 MIR140 MIR146A MIR155 MIR17
30	negative regulation of vascular associated smooth muscle cell migration	GO:1904753	9.26	ADIPOQ MIR140 MIR21 MIR223

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA binding involved in posttranscriptional gene silencing	GO:1903231	9.32	MIR423 MIR223 MIR21 MIR199A1 MIR17 MIR155
2	hormone activity	GO:0005179	9.26	LEP INS GCG ADIPOQ

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Sources for Acquired Metabolic Disease

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