Acquired Metabolic Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: ACQ009 MIFTS: 34	Acquired Metabolic Disease Categories: Metabolic diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Metabolic diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060158

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Summaries for Acquired Metabolic Disease

Disease Ontology : ¹² A disease of metabolism that has _material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to hyperuricemia and hyperprolactinemia. An important gene associated with Acquired Metabolic Disease is INS (Insulin), and among its related pathways/superpathways are Metabolism of proteins and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.. Affiliated tissues include kidney, liver and heart, and related phenotypes are homeostasis/metabolism and cardiovascular system

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Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)

#	Related Disease	Score	Top Affiliating Genes
1	hyperuricemia	32.1	CRP INS REN
2	hyperprolactinemia	10.9
3	mineral metabolism disease	10.9
4	metabolic acidosis	10.9
5	amyloidosis	10.9
6	malignant otitis externa	10.5	CRP INS
7	pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities	10.5	IGF1 INS
8	severe nonproliferative diabetic retinopathy	10.5	ALB INS
9	idiopathic recurrent pericarditis	10.5	ADIPOQ LEP
10	scleredema adultorum	10.5	INS PTH
11	generalized atherosclerosis	10.5	ACE CRP
12	benign essential hypertension	10.5	ALB REN
13	hyperinsulinemic hypoglycemia, familial, 7	10.5	GCG INS
14	kidney papillary necrosis	10.5	ALB REN
15	type 1 diabetes mellitus 15	10.5	GCG INS
16	secondary adrenal insufficiency	10.5	IGF1 INS
17	renal artery obstruction	10.5	ACE REN
18	cold agglutinin disease	10.5	CRP IL6
19	skin sarcoidosis	10.5	ACE TNF
20	uveoparotid fever	10.5	ACE TNF
21	angioimmunoblastic lymphadenopathy with dysproteinemia	10.4	IL6 TNF
22	drug reaction with eosinophilia and systemic symptoms	10.4	CRP TNF
23	autoimmune myocarditis	10.4	PPARG TNF
24	subacute cutaneous lupus erythematosus	10.4	ACE TNF
25	acute adrenal insufficiency	10.4	IL6 REN
26	severe pre-eclampsia	10.4	ADIPOQ ALB LEP
27	autosomal genetic disease	10.4	INS PSMD9 TRPV1
28	scorpion envenomation	10.4	IL6 TNF
29	leukomalacia	10.4	IL6 TNF
30	disease of mental health	10.4	BACE1 PSMD9 TRPV1
31	aortic valve disease 2	10.4	ACE CRP REN
32	hyperthyroidism	10.4	GHRL INS LEP
33	aortic aneurysm, familial abdominal, 1	10.4	ACE CRP IL6
34	carpal tunnel syndrome	10.4	IL6 INS PSMD9
35	eating disorder	10.4	ADIPOQ GHRL LEP
36	membranous nephropathy	10.4	ACE ALB TNF
37	carotid artery disease	10.4	ACE CRP REN
38	autoimmune disease of central nervous system	10.4	IL6 TNF TRPV1
39	acromegaly	10.4	GHRL IGF1 INS
40	dry eye syndrome	10.4	IL6 TNF TRPV1
41	male reproductive system disease	10.4	IGF1 IL6 TRPV1
42	bronchitis	10.4	ALB CRP TNF
43	bronchial disease	10.4	IL6 TNF TRPV1
44	otitis media	10.4	ALB IL6 TNF
45	craniopharyngioma	10.4	GHRL IGF1 INS
46	alcoholic hepatitis	10.4	ALB IL6 TNF
47	takayasu arteritis	10.4	CRP IL6 TNF
48	gastroesophageal reflux	10.4	GCG GHRL TRPV1
49	female reproductive system disease	10.4	IL6 TNF TRPV1
50	trypanosomiasis	10.4	ALB IL6 TNF

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:

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Symptoms & Phenotypes for Acquired Metabolic Disease

MGI Mouse Phenotypes related to Acquired Metabolic Disease:

⁴⁶ (show all 17)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.43	ACE ADIPOQ ALB BACE1 CRP DPP4
2	cardiovascular system	MP:0005385	10.39	ACE ADIPOQ CRP IGF1 IL6 INS
3	growth/size/body region	MP:0005378	10.39	ACE ADIPOQ BACE1 DPP4 IGF1 IL6
4	endocrine/exocrine gland	MP:0005379	10.37	ACE ADIPOQ ALB DPP4 GHRL IGF1
5	adipose tissue	MP:0005375	10.35	ACE ADIPOQ GHRL IGF1 IL6 INS
6	cellular	MP:0005384	10.35	ADIPOQ ALB BACE1 IGF1 IL6 INS
7	behavior/neurological	MP:0005386	10.3	ACE ADIPOQ BACE1 GHRL IL6 INS
8	immune system	MP:0005387	10.3	ACE ADIPOQ CRP IGF1 IL6 INS
9	hematopoietic system	MP:0005397	10.24	ACE ADIPOQ IGF1 IL6 INS IRS1
10	mortality/aging	MP:0010768	10.21	ACE ADIPOQ ALB BACE1 IGF1 IL6
11	liver/biliary system	MP:0005370	10.14	ACE ADIPOQ ALB IL6 INS IRS1
12	muscle	MP:0005369	10.1	ADIPOQ ALB BACE1 IGF1 IL6 INS
13	integument	MP:0010771	10.09	ADIPOQ BACE1 IGF1 IL6 INS LEP
14	neoplasm	MP:0002006	9.91	ACE ADIPOQ ALB IGF1 IL6 LEP
15	nervous system	MP:0003631	9.9	ADIPOQ BACE1 IGF1 IL6 INS LEP
16	renal/urinary system	MP:0005367	9.65	ACE ADIPOQ ALB IGF1 IL6 INS
17	skeleton	MP:0005390	9.28	ADIPOQ IGF1 IL6 INS IRS1 LEP

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Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

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Genetic Tests for Acquired Metabolic Disease

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Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

⁴¹

Kidney, Liver, Heart, Pancreas

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Publications for Acquired Metabolic Disease

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Genes for Acquired Metabolic Disease

Genes related to Acquired Metabolic Disease (0 elite genes):

(show top 50) (show all 59)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	INS	Insulin	Protein Coding	21.97	DISEASES inferred ¹⁵
2	TRPV1	Transient Receptor Potential Cation Channel Subfamily V Member 1	Protein Coding	21.06	DISEASES inferred ¹⁵ ¹⁵
3	LEP	Leptin	Protein Coding	20.2	DISEASES inferred ¹⁵
4	ADIPOQ	Adiponectin, C1Q And Collagen Domain Containing	Protein Coding	19.84	DISEASES inferred ¹⁵
5	BACE1	Beta-Secretase 1	Protein Coding	19.77	DISEASES inferred ¹⁵ ¹⁵
6	ALB	Albumin	Protein Coding	19.56	DISEASES inferred ¹⁵
7	CRP	C-Reactive Protein	Protein Coding	19.32	DISEASES inferred ¹⁵
8	PPARG	Peroxisome Proliferator Activated Receptor Gamma	Protein Coding	19.3	DISEASES inferred ¹⁵
9	DPP4	Dipeptidyl Peptidase 4	Protein Coding	19.18	DISEASES inferred ¹⁵
10	ACE	Angiotensin I Converting Enzyme	Protein Coding	18.94	DISEASES inferred ¹⁵
11	PTH	Parathyroid Hormone	Protein Coding	18.88	DISEASES inferred ¹⁵
12	SLC2A4	Solute Carrier Family 2 Member 4	Protein Coding	18.85	DISEASES inferred ¹⁵
13	REN	Renin	Protein Coding	18.79	DISEASES inferred ¹⁵
14	IGF1	Insulin Like Growth Factor 1	Protein Coding	18.79	DISEASES inferred ¹⁵
15	IL6	Interleukin 6	Protein Coding	18.78	DISEASES inferred ¹⁵
16	PSMD9	Proteasome 26S Subunit, Non-ATPase 9	Protein Coding	18.72	DISEASES inferred ¹⁵ ¹⁵
17	GHRL	Ghrelin And Obestatin Prepropeptide	Protein Coding	18.64	DISEASES inferred ¹⁵
18	TNF	Tumor Necrosis Factor	Protein Coding	18.57	DISEASES inferred ¹⁵
19	IRS1	Insulin Receptor Substrate 1	Protein Coding	18.56	DISEASES inferred ¹⁵
20	GCG	Glucagon	Protein Coding	10.09	DISEASES inferred ¹⁵
21	IAPP	Islet Amyloid Polypeptide	Protein Coding	8.55	DISEASES inferred ¹⁵
22	RETN	Resistin	Protein Coding	8.51	DISEASES inferred ¹⁵
23	SLC5A2	Solute Carrier Family 5 Member 2	Protein Coding	8.49	DISEASES inferred ¹⁵
24	TTR	Transthyretin	Protein Coding	8.46	DISEASES inferred ¹⁵
25	APOB	Apolipoprotein B	Protein Coding	8.46	DISEASES inferred ¹⁵
26	GIP	Gastric Inhibitory Polypeptide	Protein Coding	8.45	DISEASES inferred ¹⁵
27	SLC5A4	Solute Carrier Family 5 Member 4	Protein Coding	8.45	DISEASES inferred ¹⁵
28	TLR9	Toll Like Receptor 9	Protein Coding	8.43	DISEASES inferred ¹⁵ ¹⁵
29	UCP1	Uncoupling Protein 1	Protein Coding	8.43	DISEASES inferred ¹⁵
30	POMC	Proopiomelanocortin	Protein Coding	8.4	DISEASES inferred ¹⁵
31	COG2	Component Of Oligomeric Golgi Complex 2	Protein Coding	8.36	DISEASES inferred ¹⁵
32	GLP1R	Glucagon Like Peptide 1 Receptor	Protein Coding	8.35	DISEASES inferred ¹⁵
33	IER3IP1	Immediate Early Response 3 Interacting Protein 1	Protein Coding	8.34	DISEASES inferred ¹⁵ ¹⁵
34	AKT1	AKT Serine/Threonine Kinase 1	Protein Coding	8.32	DISEASES inferred ¹⁵
35	FTO	FTO, Alpha-Ketoglutarate Dependent Dioxygenase	Protein Coding	8.28	DISEASES inferred ¹⁵
36	LEPR	Leptin Receptor	Protein Coding	8.25	DISEASES inferred ¹⁵
37	PRL	Prolactin	Protein Coding	8.22	DISEASES inferred ¹⁵
38	HBA2	Hemoglobin Subunit Alpha 2	Protein Coding	8.22	DISEASES inferred ¹⁵
39	NPY	Neuropeptide Y	Protein Coding	8.19	DISEASES inferred ¹⁵
40	MC4R	Melanocortin 4 Receptor	Protein Coding	8.19	DISEASES inferred ¹⁵
41	GCK	Glucokinase	Protein Coding	8.15	DISEASES inferred ¹⁵
42	TNNI3K	TNNI3 Interacting Kinase	Protein Coding	8.15	DISEASES inferred ¹⁵ ¹⁵
43	NOS3	Nitric Oxide Synthase 3	Protein Coding	8.09	DISEASES inferred ¹⁵
44	SST	Somatostatin	Protein Coding	8.08	DISEASES inferred ¹⁵
45	IL1B	Interleukin 1 Beta	Protein Coding	8.07	DISEASES inferred ¹⁵
46	SERPINE1	Serpin Family E Member 1	Protein Coding	8.06	DISEASES inferred ¹⁵
47	GAD2	Glutamate Decarboxylase 2	Protein Coding	8.05	DISEASES inferred ¹⁵
48	SLC2A2	Solute Carrier Family 2 Member 2	Protein Coding	7.94	DISEASES inferred ¹⁵
49	CCL2	C-C Motif Chemokine Ligand 2	Protein Coding	7.9	DISEASES inferred ¹⁵
50	SREBF1	Sterol Regulatory Element Binding Transcription Factor 1	Protein Coding	7.88	DISEASES inferred ¹⁵

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Variations for Acquired Metabolic Disease

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Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

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Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 30)

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of proteins ⁶⁶ Show member pathways Post-translational protein modification ⁶⁶	13.75	ACE BACE1 DPP4 GCG GHRL IGF1
2	Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. ⁶⁶ Show member pathways Alzheimer disease ³⁷ Alzheimers Disease ¹ Complex I biogenesis ⁶⁶ Electron Transport Chain ¹ Formation of ATP by chemiosmotic coupling ⁶⁶ Huntington disease ³⁷ Non-alcoholic fatty liver disease (NAFLD) ³⁷ Oxidative phosphorylation ³⁷ Oxidative phosphorylation ¹ Parkinson disease ³⁷ Respiratory electron transport ⁶⁶ The citric acid (TCA) cycle and respiratory electron transport ⁶⁶ Thermogenesis ³⁷	13.49	ADIPOQ BACE1 GCG IL6 INS IRS1
3	Developmental Biology ⁶⁶ Show member pathways Axon guidance ⁶⁶	13.45	ADIPOQ INS IRS1 LEP PPARG PSMD9
4	p70S6K Signaling ⁶⁴ Show member pathways mTOR Pathway ⁶⁴ Renin-Angiotensin Pathway ⁶⁴	13.01	ACE IGF1 IL6 INS IRS1 REN
5	Common Cytokine Receptor Gamma-Chain Family Signaling Pathways ⁶⁵ Show member pathways Adipokines and Insulin Signaling Pathways ⁶⁵ Development Thrombopoietin-regulated cell processes ²² IL-15 Signaling Pathways ⁶⁵ IL-2 Signaling Pathways ⁶⁵ IL-21 Signaling Pathways ⁶⁵ IL-4 Signaling Pathways ⁶⁵ IL-7 Signaling Pathways ⁶⁵ IL-9 Pathway ⁶⁴ IL-9 Signaling Pathways ⁶⁵ Immune response IL-9 signaling pathway ²²	12.68	ADIPOQ IL6 INS IRS1 LEP SLC2A4
6	Glucose / Energy Metabolism ⁴	12.46	ADIPOQ GCG INS IRS1 PPARG SLC2A4
7	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.29	ALB CRP IL6 INS TNF
8	Circadian rythm related genes ¹	12.26	ADIPOQ GHRL IL6 LEP PPARG
9	AMP-activated Protein Kinase (AMPK) Signaling ¹ Show member pathways AMPK signaling pathway ³⁷ AMPK Signaling Pathway ⁶⁷	12.22	ADIPOQ IGF1 INS IRS1 LEP PPARG
10	Dilated cardiomyopathy (DCM) ³⁷ Show member pathways Hypertrophic cardiomyopathy (HCM) ³⁷	12.16	ACE IGF1 IL6 TNF
11	AMPK Enzyme Complex Pathway ⁶⁴ Show member pathways Chromatin Remodeling ⁶⁴ mitochondrial L-carnitine shuttle ¹	12.15	INS IRS1 LEP SLC2A4
12	Longevity regulating pathway ³⁷ Show member pathways Longevity regulating pathway - multiple species ³⁷	12.09	ADIPOQ IGF1 INS IRS1 PPARG
13	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Insulin processing ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶	12.02	ACE DPP4 GCG GHRL IGF1 INS
14	FoxO signaling pathway ³⁷ Show member pathways PLK2 and PLK4 events ¹ Polo-like kinase signaling events in the cell cycle ¹	12.01	IGF1 IL6 INS IRS1 SLC2A4
15	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12	ALB IGF1 IL6 INS
16	Insulin resistance ³⁷ Show member pathways protein O-[N-acetyl]-glucosylation ¹	11.84	IL6 INS IRS1 SLC2A4 TNF
17	Type II diabetes mellitus ³⁷ ¹ Show member pathways Anti-diabetic Drug Potassium Channel Inhibitors Pathway, Pharmacodynamics ⁶¹	11.75	ADIPOQ INS IRS1 SLC2A4 TNF
18	Adipogenesis ¹	11.73	ADIPOQ IGF1 IL6 INS IRS1 LEP
19	Microglia Activation During Neuroinflammation: Microglia Polarization ⁶⁵	11.68	IGF1 IL6 PPARG TNF
20	Lung fibrosis ¹	11.62	IGF1 IL6 TNF
21	Incretin synthesis, secretion, and inactivation ⁶⁶ Show member pathways Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ⁶⁶ Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) ⁶⁶	11.56	DPP4 GCG LEP
22	Adipocytokine signaling pathway ³⁷	11.56	ADIPOQ IRS1 LEP SLC2A4 TNF
23	Development_Leptin signaling via PI3K-dependent pathway ²²	11.51	IRS1 LEP SLC2A4
24	Signaling events mediated by PTP1B ¹	11.48	INS IRS1 LEP
25	Differentiation Pathway ¹	11.46	IGF1 IL6 INS
26	Transcription_Role of VDR in regulation of genes involved in osteoporosis ²²	11.39	IGF1 IL6 PTH TNF
27	Aldosterone-regulated sodium reabsorption ³⁷	11.34	IGF1 INS IRS1
28	Differentiation of white and brown adipocyte ¹	11.14	ADIPOQ LEP PPARG
29	Overview of nanoparticle effects ¹	10.99	CRP IL6 TNF
30	Transcription factor regulation in adipogenesis ¹	10.51	ADIPOQ IL6 IRS1 LEP PPARG SLC2A4

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GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.8	ACE ADIPOQ ALB CRP DPP4 GCG
2	endoplasmic reticulum lumen	GO:0005788	9.63	ALB BACE1 GCG GHRL IL6 INS
3	membrane raft	GO:0045121	9.56	BACE1 DPP4 SLC2A4 TNF
4	extracellular space	GO:0005615	9.44	ACE ADIPOQ ALB CRP GCG GHRL

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 40)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular protein metabolic process	GO:0044267	9.93	ALB BACE1 IGF1 IL6 INS
2	positive regulation of protein kinase B signaling	GO:0051897	9.92	INS IRS1 LEP TNF
3	positive regulation of MAPK cascade	GO:0043410	9.89	IGF1 IL6 INS LEP
4	response to ethanol	GO:0045471	9.87	ADIPOQ LEP PTH SLC2A4
5	positive regulation of peptidyl-tyrosine phosphorylation	GO:0050731	9.85	ADIPOQ IGF1 IL6
6	positive regulation of peptidyl-serine phosphorylation	GO:0033138	9.85	GCG IL6 TNF
7	response to nutrient	GO:0007584	9.85	ADIPOQ LEP PPARG
8	cellular response to insulin stimulus	GO:0032869	9.85	ADIPOQ IRS1 PPARG SLC2A4
9	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.83	IGF1 IL6 LEP
10	response to glucocorticoid	GO:0051384	9.83	ADIPOQ IL6 TNF
11	positive regulation of protein kinase activity	GO:0045860	9.81	ADIPOQ GCG TNF
12	positive regulation of smooth muscle cell proliferation	GO:0048661	9.81	IGF1 IL6 TNF
13	positive regulation of phosphatidylinositol 3-kinase signaling	GO:0014068	9.81	IGF1 INS LEP TNF
14	hormone-mediated signaling pathway	GO:0009755	9.8	GHRL PPARG REN
15	regulation of insulin secretion	GO:0050796	9.8	DPP4 GCG LEP TNF
16	negative regulation of fat cell differentiation	GO:0045599	9.79	ADIPOQ IL6 TNF
17	glucose metabolic process	GO:0006006	9.77	ADIPOQ GHRL INS LEP TNF
18	acute-phase response	GO:0006953	9.76	CRP IL6 INS
19	regulation of blood pressure	GO:0008217	9.76	ACE LEP PPARG REN
20	negative regulation of insulin secretion	GO:0046676	9.73	GHRL IRS1 PSMD9
21	glucose homeostasis	GO:0042593	9.73	ADIPOQ INS IRS1 LEP PPARG SLC2A4
22	response to nutrient levels	GO:0031667	9.71	ADIPOQ GHRL LEP PTH
23	positive regulation of insulin receptor signaling pathway	GO:0046628	9.7	INS IRS1 LEP
24	regulation of protein secretion	GO:0050708	9.68	INS TNF
25	angiotensin maturation	GO:0002003	9.67	ACE REN
26	adult feeding behavior	GO:0008343	9.67	GHRL LEP
27	negative regulation of blood vessel diameter	GO:0097756	9.66	CRP INS
28	neutrophil mediated immunity	GO:0002446	9.65	ACE IL6
29	amyloid-beta metabolic process	GO:0050435	9.65	ACE BACE1 REN
30	negative regulation of acute inflammatory response	GO:0002674	9.64	INS PPARG
31	positive regulation of neuroinflammatory response	GO:0150078	9.63	IL6 TNF
32	positive regulation of glycogen biosynthetic process	GO:0045725	9.62	IGF1 INS IRS1 PTH
33	bone mineralization involved in bone maturation	GO:0035630	9.61	IGF1 LEP
34	negative regulation of macrophage derived foam cell differentiation	GO:0010745	9.61	ADIPOQ CRP PPARG
35	negative regulation of lipid storage	GO:0010888	9.46	CRP IL6 LEP TNF
36	positive regulation of glucose import	GO:0046326	9.35	ADIPOQ IGF1 INS IRS1 PTH
37	regulation of signaling receptor activity	GO:0010469	9.28	ADIPOQ GCG GHRL IGF1 IL6 INS
38	negative regulation of apoptotic process	GO:0043066	10.08	ALB GCG GHRL IGF1 IL6 LEP
39	positive regulation of cell proliferation	GO:0008284	10.05	DPP4 IGF1 IL6 INS IRS1 LEP
40	positive regulation of gene expression	GO:0010628	10.04	CRP IGF1 IL6 INS TNF

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.81	ADIPOQ ALB CRP DPP4 GCG INS
2	signaling receptor binding	GO:0005102	9.72	ADIPOQ DPP4 GCG LEP REN
3	endopeptidase activity	GO:0004175	9.61	ACE BACE1 REN
4	drug binding	GO:0008144	9.54	ACE ALB PPARG
5	insulin receptor binding	GO:0005158	9.43	IGF1 INS IRS1
6	peptide hormone receptor binding	GO:0051428	9.4	LEP PTH
7	insulin-like growth factor receptor binding	GO:0005159	9.26	IGF1 INS IRS1 REN
8	hormone activity	GO:0005179	9.17	ADIPOQ GCG GHRL IGF1 INS LEP

Sources

Sources for Acquired Metabolic Disease

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

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³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

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⁴⁴ MeSH

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⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia