MCID: ACQ009
MIFTS: 26

Acquired Metabolic Disease

Categories: Metabolic diseases, Rare diseases

Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease 12 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0060158

Summaries for Acquired Metabolic Disease

Disease Ontology : 12 A disease of metabolism that has material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to hyperprolactinemia and mineral metabolism disease. An important gene associated with Acquired Metabolic Disease is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways is MicroRNAs in cancer. Affiliated tissues include liver.

Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder Metabolic Disease Due to Other Fatty Acid Oxidation Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 289)
# Related Disease Score Top Affiliating Genes
1 hyperprolactinemia 11.1
2 mineral metabolism disease 11.1
3 metabolic acidosis 11.1
4 hyperuricemia 11.1
5 amyloidosis 11.1
6 skin disease 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR146A
7 bone inflammation disease 11.0 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR155
8 autosomal genetic disease 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR146A MIR142
9 central nervous system cancer 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR142
10 leukocyte disease 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR142
11 contractures, pterygia, and spondylocarpotarsal fusion syndrome 1a 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR140
12 arteries, anomalies of 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
13 breast disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
14 integumentary system disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
15 cardiovascular system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
16 pulmonary disease, chronic obstructive 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
17 upper respiratory tract disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
18 eye disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
19 spinal disease 11.0 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR155
20 cell type benign neoplasm 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR142
21 urinary system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
22 connective tissue cancer 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
23 bronchial disease 11.0 SERPINA3 MIR21 MIR17 MIR155 MIR142 MIR140
24 mouth disease 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR142
25 connective tissue disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
26 thyroid gland disease 11.0 SERPINA3 MIR199A1 MIR17 MIR142 LEP INS
27 autonomic nervous system neoplasm 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR126
28 peripheral nervous system neoplasm 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 MIR126
29 female reproductive system disease 11.0 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1
30 peripheral nervous system disease 11.0 SERPINA3 MIR21 MIR146A MIR142 MIR126 LEP
31 nervous system disease 11.0 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1
32 leukemia, acute myeloid 11.0 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1
33 esophageal disease 11.0 MIR423 MIR223 MIR21 MIR199A1 MIR17 MIR146A
34 inherited metabolic disorder 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR142
35 muscular disease 11.0 SERPINA3 MIR199A1 MIR142 MIR140 MIR126 INS
36 extrinsic cardiomyopathy 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR142
37 heart conduction disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR146A MIR142
38 colonic disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
39 pharynx cancer 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR142
40 prostate disease 11.0 SERPINA3 MIR29A MIR223 MIR21 MIR199A1 MIR17
41 disease of mental health 11.0 SERPINA3 MIR29A MIR223 MIR21 MIR199A1 MIR17
42 gastrointestinal system benign neoplasm 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR142 INS
43 lipid storage disease 11.0 SERPINA3 MIR21 MIR199A1 MIR155 MIR142 LEP
44 reproductive system disease 11.0 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1
45 immune system disease 11.0 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1
46 autoimmune disease of musculoskeletal system 11.0 SERPINA3 MIR423 MIR21 MIR155 MIR146A MIR142
47 lymphatic system disease 11.0 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1
48 diabetes mellitus, noninsulin-dependent 11.0 SERPINA3 MIR423 MIR29A MIR21 MIR199A1 MIR17
49 thoracic cancer 11.0 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1
50 male reproductive system disease 11.0 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:



Diseases related to Acquired Metabolic Disease

Symptoms & Phenotypes for Acquired Metabolic Disease

Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

Genetic Tests for Acquired Metabolic Disease

Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

40
Liver

Publications for Acquired Metabolic Disease

Articles related to Acquired Metabolic Disease:

# Title Authors PMID Year
1
Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates. 61
30745819 2019
2
Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China. 61
25688884 2015
3
[Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. 61
17452309 2007

Variations for Acquired Metabolic Disease

Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 MIR423 MIR29A MIR223 MIR21 MIR199A1 MIR17

GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.53 SERPINA3 MIR423 MIR29A MIR223 MIR21 MIR199A1
2 extracellular vesicle GO:1903561 9.35 MIR29A MIR21 MIR17 MIR126 MIR103A1

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 36)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.97 MIR146A MIR155 MIR17 MIR21 MIR29A
2 cellular response to lipopolysaccharide GO:0071222 9.91 MIR140 MIR146A MIR17 MIR21
3 positive regulation of gene expression GO:0010628 9.91 INS MIR140 MIR146A MIR155 MIR21 MIR223
4 positive regulation of angiogenesis GO:0045766 9.88 MIR126 MIR199A1 MIR21 MIR29A
5 positive regulation of inflammatory response GO:0050729 9.84 MIR126 MIR155 MIR21
6 negative regulation of inflammatory response GO:0050728 9.8 MIR126 MIR142 MIR146A MIR155 MIR223
7 positive regulation of endothelial cell migration GO:0010595 9.79 MIR199A1 MIR21 MIR29A
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.78 INS LEP MIR126 MIR21
9 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.77 MIR146A MIR155 MIR199A1
10 negative regulation of cytokine production involved in inflammatory response GO:1900016 9.73 MIR140 MIR146A MIR155
11 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.72 MIR146A MIR21 MIR223
12 cellular response to hypoxia GO:0071456 9.72 MIR126 MIR140 MIR146A MIR155 MIR17
13 positive regulation of activated T cell proliferation GO:0042104 9.71 ICOSLG MIR155 MIR21
14 positive regulation of vascular endothelial cell proliferation GO:1905564 9.7 MIR126 MIR21 MIR29A
15 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903589 9.69 MIR126 MIR146A MIR21
16 negative regulation of hydrogen peroxide-induced cell death GO:1903206 9.67 MIR155 MIR17
17 positive regulation of connective tissue replacement GO:1905205 9.67 MIR155 MIR199A1
18 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.67 MIR140 MIR21 MIR223
19 negative regulation of toll-like receptor 4 signaling pathway GO:0034144 9.66 MIR140 MIR146A
20 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.65 MIR146A MIR155
21 positive regulation of microglial cell activation GO:1903980 9.65 MIR142 MIR155
22 negative regulation of matrix metallopeptidase secretion GO:1904465 9.65 MIR146A MIR199A1
23 negative regulation of interleukin-8 production GO:0032717 9.64 MIR146A MIR155
24 negative regulation of cartilage development GO:0061037 9.64 LEP MIR21
25 positive regulation of metalloendopeptidase activity GO:1904685 9.63 MIR17 MIR21
26 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.63 MIR146A MIR155
27 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.63 MIR155 MIR17 MIR199A1
28 positive regulation of protein kinase B signaling GO:0051897 9.63 INS LEP MIR126 MIR199A1 MIR21 MIR29A
29 negative regulation of regulatory T cell differentiation GO:0045590 9.62 MIR155 MIR21
30 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.62 MIR17 MIR21
31 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.61 MIR155 MIR17 MIR199A1
32 positive regulation of necroptotic process GO:0060545 9.6 MIR103A1 MIR155
33 negative regulation of necrotic cell death GO:0060547 9.58 MIR155 MIR223
34 negative regulation of vascular endothelial growth factor production GO:1904046 9.56 MIR140 MIR146A MIR17 MIR199A1
35 miRNA mediated inhibition of translation GO:0035278 9.43 MIR103A1 MIR146A MIR155 MIR17 MIR21 MIR29A
36 gene silencing by miRNA GO:0035195 9.4 MIR103A1 MIR126 MIR140 MIR142 MIR146A MIR155

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.4 MIR423 MIR29A MIR223 MIR21 MIR199A1 MIR17

Sources for Acquired Metabolic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
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43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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