MCID: ACQ009
MIFTS: 28

Acquired Metabolic Disease

Categories: Genetic diseases, Metabolic diseases, Rare diseases

Aliases & Classifications for Acquired Metabolic Disease

MalaCards integrated aliases for Acquired Metabolic Disease:

Name: Acquired Metabolic Disease 12 15 17

Classifications:



External Ids:

Disease Ontology 12 DOID:0060158

Summaries for Acquired Metabolic Disease

Disease Ontology : 12 A disease of metabolism that has material basis in enzyme deficiency or accumulation of enzymes or toxins which interfere with normal function due to an endocrine organ disease, organ malfunction, inadequate intake, dietary deficiency, or malabsorption.

MalaCards based summary : Acquired Metabolic Disease is related to mineral metabolism disease and hyperuricemia. An important gene associated with Acquired Metabolic Disease is H2AC18 (H2A Clustered Histone 18), and among its related pathways/superpathways is MicroRNAs in cancer. Affiliated tissues include liver, bone and heart.

Related Diseases for Acquired Metabolic Disease

Diseases in the Acquired Metabolic Disease family:

Inherited Metabolic Disorder Metabolic Disease Due to Other Fatty Acid Oxidation Disorder

Diseases related to Acquired Metabolic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 323)
# Related Disease Score Top Affiliating Genes
1 mineral metabolism disease 32.9 INS H2AC18 ALB
2 hyperuricemia 32.7 LEP INS ALB
3 hyperprolactinemia 11.1
4 metabolic acidosis 11.1
5 amyloidosis 11.1
6 prostate disease 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR155 MIR146A
7 connective tissue cancer 11.0 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR140
8 peripheral nervous system disease 11.0 SERPINA3 MIR21 MIR126 INS ICOSLG H2AC18
9 autosomal genetic disease 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR140 MIR126
10 gonadal disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
11 bone inflammation disease 11.0 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR155
12 cervix disease 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR146A MIR140
13 breast disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
14 endocrine system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
15 disease of mental health 11.0 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR140
16 bronchial disease 11.0 SERPINA3 MIR21 MIR17 MIR155 MIR140 MIR126
17 bone marrow cancer 11.0 MIR21 MIR199A1 MIR17 MIR155 MIR140 MIR126
18 inherited metabolic disorder 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR126 LEP
19 nervous system disease 11.0 SERPINA3 MIR223 MIR21 MIR199A1 MIR17 MIR155
20 gastrointestinal system benign neoplasm 11.0 SERPINA3 MIR21 MIR199A1 MIR17 INS H2AC18
21 thoracic cancer 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
22 eye disease 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR140 MIR126
23 male reproductive system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
24 stomach disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR146A
25 reproductive system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
26 autoimmune disease of musculoskeletal system 11.0 SERPINA3 MIR223 MIR21 MIR155 MIR146A MIR140
27 male reproductive organ cancer 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
28 connective tissue disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
29 gastrointestinal system cancer 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
30 immune system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
31 hematologic cancer 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
32 female reproductive system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
33 leukocyte disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
34 cardiovascular system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
35 cell type cancer 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
36 thyroid gland disease 11.0 MIR423 MIR21 MIR199A1 MIR17 MIR146A MIR140
37 uterine anomalies 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR146A
38 respiratory system cancer 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
39 bladder disease 11.0 MIR423 MIR21 MIR199A1 MIR17 MIR146A MIR140
40 endocrine organ benign neoplasm 11.0 SERPINA3 MIR21 MIR199A1 MIR17 MIR126 INS
41 arteries, anomalies of 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
42 colonic disease 11.0 MIR423 MIR21 MIR199A1 MIR17 MIR155 MIR140
43 nervous system cancer 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR155
44 diabetes mellitus, noninsulin-dependent 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR146A
45 gastrointestinal system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
46 intestinal disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
47 urinary system disease 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17
48 upper respiratory tract disease 11.0 SERPINA3 MIR423 MIR21 MIR199A1 MIR17 MIR140
49 leukemia, chronic lymphocytic 11.0 MIR423 MIR223 MIR21 MIR199A1 MIR17 MIR155
50 endocrine gland cancer 11.0 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17

Graphical network of the top 20 diseases related to Acquired Metabolic Disease:



Diseases related to Acquired Metabolic Disease

Symptoms & Phenotypes for Acquired Metabolic Disease

Drugs & Therapeutics for Acquired Metabolic Disease

Search Clinical Trials , NIH Clinical Center for Acquired Metabolic Disease

Genetic Tests for Acquired Metabolic Disease

Anatomical Context for Acquired Metabolic Disease

MalaCards organs/tissues related to Acquired Metabolic Disease:

40
Liver, Bone, Heart, Skin, Lung, Thyroid, B Cells

Publications for Acquired Metabolic Disease

Articles related to Acquired Metabolic Disease:

# Title Authors PMID Year
1
Role of Nutrition in the Pathogenesis and Prevention of Non-alcoholic Fatty Liver Disease: Recent Updates. 61
30745819 2019
2
Polymorphism of rs7688672 and rs10033237 in cGKII/PRKG2 and gout susceptibility of Han population in northern China. 61
25688884 2015
3
[Common occurrence of non-alcoholic fatty liver disease and cholecystolithiasis]. 61
17452309 2007

Variations for Acquired Metabolic Disease

Expression for Acquired Metabolic Disease

Search GEO for disease gene expression data for Acquired Metabolic Disease.

Pathways for Acquired Metabolic Disease

Pathways related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.77 MIR423 MIR223 MIR21 MIR199A1 MIR17 MIR155

GO Terms for Acquired Metabolic Disease

Cellular components related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.53 SERPINA3 MIR423 MIR223 MIR21 MIR199A1 MIR17

Biological processes related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

(show all 30)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of gene expression GO:0010629 9.95 MIR146A MIR155 MIR17 MIR21
2 positive regulation of gene expression GO:0010628 9.95 INS MIR140 MIR146A MIR155 MIR21 MIR223
3 cellular response to lipopolysaccharide GO:0071222 9.88 MIR140 MIR146A MIR17 MIR21
4 cellular response to insulin stimulus GO:0032869 9.82 ADIPOQ EPRS1 MIR103A1
5 positive regulation of inflammatory response GO:0050729 9.8 MIR126 MIR155 MIR21
6 positive regulation of protein kinase B signaling GO:0051897 9.8 INS LEP MIR126 MIR199A1 MIR21
7 glucose metabolic process GO:0006006 9.77 ADIPOQ INS LEP
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 INS LEP MIR126 MIR21
9 negative regulation of inflammatory response GO:0050728 9.72 ADIPOQ MIR126 MIR146A MIR155 MIR223
10 negative regulation of vascular smooth muscle cell proliferation GO:1904706 9.71 ADIPOQ MIR140 MIR223
11 positive regulation of glucose import GO:0046326 9.7 ADIPOQ INS MIR223
12 negative regulation of NIK/NF-kappaB signaling GO:1901223 9.69 MIR146A MIR21 MIR223
13 positive regulation of activated T cell proliferation GO:0042104 9.67 ICOSLG MIR155 MIR21
14 cellular response to hypoxia GO:0071456 9.65 MIR126 MIR140 MIR146A MIR155 MIR17
15 positive regulation of connective tissue replacement GO:1905205 9.64 MIR155 MIR199A1
16 negative regulation of toll-like receptor 4 signaling pathway GO:0034144 9.63 MIR140 MIR146A
17 cellular response to oxidised low-density lipoprotein particle stimulus GO:0140052 9.62 MIR146A MIR155
18 negative regulation of cartilage development GO:0061037 9.62 LEP MIR21
19 positive regulation of metalloendopeptidase activity GO:1904685 9.61 MIR17 MIR21
20 negative regulation of regulatory T cell differentiation GO:0045590 9.61 MIR155 MIR21
21 negative regulation of low-density lipoprotein particle clearance GO:0010989 9.61 MIR155 MIR17 MIR199A1
22 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.59 MIR146A MIR155
23 negative regulation of vascular associated smooth muscle cell apoptotic process GO:1905460 9.58 MIR17 MIR21
24 positive regulation of necroptotic process GO:0060545 9.57 MIR103A1 MIR155
25 negative regulation of protein oligomerization GO:0032460 9.56 ALB INS
26 negative regulation of necrotic cell death GO:0060547 9.55 MIR155 MIR223
27 miRNA mediated inhibition of translation GO:0035278 9.55 MIR103A1 MIR146A MIR155 MIR17 MIR21
28 positive regulation of cardiac muscle hypertrophy in response to stress GO:1903244 9.54 MIR155 MIR17 MIR199A1
29 gene silencing by miRNA GO:0035195 9.32 MIR103A1 MIR126 MIR140 MIR146A MIR155 MIR17
30 negative regulation of vascular associated smooth muscle cell migration GO:1904753 9.26 ADIPOQ MIR140 MIR21 MIR223

Molecular functions related to Acquired Metabolic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.32 MIR423 MIR223 MIR21 MIR199A1 MIR17 MIR155
2 hormone activity GO:0005179 9.26 LEP INS GCG ADIPOQ

Sources for Acquired Metabolic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....