MCID: ACQ047
MIFTS: 28

Acquired Methemoglobinemia

Categories: Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Acquired Methemoglobinemia

MalaCards integrated aliases for Acquired Methemoglobinemia:

Name: Acquired Methemoglobinemia 60 74
Drug-Induced Methemoglobinemia 60 74
Methemoglobinemia Acquired 56

Classifications:



External Ids:

ICD10 via Orphanet 35 D74.8
Orphanet 60 ORPHA464453

Summaries for Acquired Methemoglobinemia

MalaCards based summary : Acquired Methemoglobinemia, also known as drug-induced methemoglobinemia, is related to methemoglobinemia and hemolytic anemia. An important gene associated with Acquired Methemoglobinemia is HBG2 (Hemoglobin Subunit Gamma 2), and among its related pathways/superpathways is Methylene Blue Pathway, Pharmacodynamics. The drug Methylene blue has been mentioned in the context of this disorder. Affiliated tissues include lung and heart, and related phenotype is Increased shRNA abundance.

Related Diseases for Acquired Methemoglobinemia

Graphical network of the top 20 diseases related to Acquired Methemoglobinemia:



Diseases related to Acquired Methemoglobinemia

Symptoms & Phenotypes for Acquired Methemoglobinemia

GenomeRNAi Phenotypes related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.62 G6PD HBG2

Drugs & Therapeutics for Acquired Methemoglobinemia

Drugs for Acquired Methemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 4 61-73-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MEthylene Blue In Patients With Acquired Methemoglobinemia Recruiting NCT03395223 Phase 4 Methylene Blue
2 Acquired Methemoglobinemia Observational Registry Recruiting NCT03542760 Methylene Blue

Search NIH Clinical Center for Acquired Methemoglobinemia

Genetic Tests for Acquired Methemoglobinemia

Anatomical Context for Acquired Methemoglobinemia

MalaCards organs/tissues related to Acquired Methemoglobinemia:

42
Lung, Heart

Publications for Acquired Methemoglobinemia

Articles related to Acquired Methemoglobinemia:

(show all 49)
# Title Authors Year
1
Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report. ( 29627919 )
2018
2
Acquired Methemoglobinemia - A Sporadic Holi Disaster. ( 28667718 )
2017
3
Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury. ( 28969436 )
2017
4
Letter in response to "Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury". ( 29164951 )
2017
5
Do all patients with acquired methemoglobinemia need treatment? A lesson learnt. ( 26486118 )
2015
6
Patient with terbinafine-induced subacute cutaneous lupus erythematosus followed by thalidomide-induced orofacial neuropathy; Beta blocker use, hypertension, and the risk of psoriasis; eczematous reaction to intravenous immunoglobulin; nicolau syndrome after intra-articular glucocorticoid injection; troponin leak associated with drug-induced methemoglobinemia. ( 25684795 )
2015
7
Understanding acquired methemoglobinemia. ( 24430394 )
2014
8
A rare case of acquired methemoglobinemia associated with alkaptonuria. ( 25130113 )
2014
9
Troponin leak associated with drug-induced methemoglobinemia. ( 24686024 )
2014
10
Evaluation and management of acquired methemoglobinemia associated with topical benzocaine use. ( 23696166 )
2013
11
Acquired methemoglobinemia due to contaminated Holi colors - a rare but preventable complication. ( 22700388 )
2013
12
A patient with rheumatic heart disease presented with central cyanosis due to acquired methemoglobinemia during late pregnancy - A rare association. ( 24027374 )
2013
13
Two cases of acquired methemoglobinemia. ( 23136811 )
2012
14
Acquired methemoglobinemia due to application of prilocaine during circumcision. ( 20851555 )
2012
15
Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures. ( 22915889 )
2011
16
Acquired methemoglobinemia in infants. ( 27264127 )
2011
17
[Acquired methemoglobinemia--case report]. ( 20306428 )
2010
18
Acquired methemoglobinemia revisited. ( 20831930 )
2010
19
Acquired methemoglobinemia due to contaminated colours: a preventable disaster. ( 19158164 )
2009
20
Case 1: Chocolate-coloured blood in infant with shock (case presentation). Diagnosis: Acquired methemoglobinemia. ( 18532933 )
2008
21
When brown and blue make red: a case of acquired methemoglobinemia. ( 16701115 )
2006
22
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. ( 15342970 )
2004
23
Acquired methemoglobinemia: a rare but serious complication. ( 12971073 )
2003
24
Drug-induced methemoglobinemia during thoracoscopic lung biopsy. ( 11235734 )
2001
25
Acquired methemoglobinemia in anemic cattle infected with Theileria sergenti. ( 11705651 )
2001
26
Acquired methemoglobinemia following benzocaine anesthesia of the pharynx. ( 10800606 )
2000
27
When patients become cyanotic: acquired methemoglobinemia. ( 10377640 )
1999
28
[Congenital and acquired methemoglobinemia and its therapy]. ( 9588101 )
1998
29
Treatment of high-risk, refractory acquired methemoglobinemia with automated red blood cell exchange. ( 9590495 )
1998
30
Acquired methemoglobinemia possibly related to phenazopyridine in a woman with normal renal function. ( 9302157 )
1997
31
Acquired methemoglobinemia from multiple oxidants. ( 8211336 )
1993
32
Drug-induced methemoglobinemia in a healthy 20-year-old soldier undergoing shoulder surgery. ( 8136402 )
1993
33
Acquired methemoglobinemia from amyl nitrate inhalation. ( 1346813 )
1992
34
Acquired methemoglobinemia. The relationship of cause to course of illness. ( 2288611 )
1990
35
Acquired methemoglobinemia. A case report. ( 3509124 )
1987
36
A resuscitation puzzle: acute acquired methemoglobinemia. ( 3568733 )
1987
37
Acquired methemoglobinemia and hemolytic anemia after usual doses of phenazopyridine. ( 7075467 )
1982
38
Acquired methemoglobinemia in leukemia: its etiopathogenesis and possible effects on red cell structure and function. ( 6943400 )
1981
39
Acquired methemoglobinemia. ( 7210666 )
1981
40
Phenazopyridine hydrochloride toxicity: a cause of drug-induced methemoglobinemia. ( 385954 )
1979
41
Effect of selenite on drug-induced methemoglobinemia in rats. ( 497001 )
1979
42
The importance of direct measurements of arterial blood gases in drug-induced methemoglobinemia. ( 244478 )
1978
43
The importance of direct measurements of arterial blood gases in drug-induced methemoglobinemia. ( 246866 )
1978
44
The importance of direct measurements of arterial blood gases in drug-induced methemoglobinemia. ( 248376 )
1978
45
Acquired methemoglobinemia. A case report. ( 4710727 )
1973
46
Drug-induced methemoglobinemia. ( 4577648 )
1973
47
Acquired methemoglobinemia and hemolytic anemia following excessive pyridium (phenazopyridine hydrochloride) ingestion. ( 5095165 )
1971
48
Acquired methemoglobinemia due to ingestion of acetophenetidin. Report of a case in a small infant. ( 14494183 )
1962
49
Acquired methemoglobinemia in an infant due to benzocaine suppository. ( 14432244 )
1960

Variations for Acquired Methemoglobinemia

Expression for Acquired Methemoglobinemia

Search GEO for disease gene expression data for Acquired Methemoglobinemia.

Pathways for Acquired Methemoglobinemia

Pathways related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.23 CYB5R3 G6PD

GO Terms for Acquired Methemoglobinemia

Cellular components related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin complex GO:0005833 8.62 CYB5R3 HBG2

Biological processes related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 8.96 CYB5R3 G6PD
2 cholesterol biosynthetic process GO:0006695 8.62 CYB5R3 G6PD

Molecular functions related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.62 CYB5R3 G6PD

Sources for Acquired Methemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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