MCID: ACQ047
MIFTS: 30

Acquired Methemoglobinemia

Categories: Blood diseases, Genetic diseases, Rare diseases

Aliases & Classifications for Acquired Methemoglobinemia

Summaries for Acquired Methemoglobinemia

MalaCards based summary : Acquired Methemoglobinemia, also known as drug-induced methemoglobinemia, is related to methemoglobinemia and hemolytic anemia. An important gene associated with Acquired Methemoglobinemia is HBG2 (Hemoglobin Subunit Gamma 2), and among its related pathways/superpathways is Methylene Blue Pathway, Pharmacodynamics. The drug Methylene blue has been mentioned in the context of this disorder. Related phenotypes are methemoglobinemia and vomiting

Related Diseases for Acquired Methemoglobinemia

Diseases in the Methemoglobinemia family:

Methemoglobinemia, Beta Type Methemoglobinemia, Alpha Type
Congenital Methemoglobinemia Acquired Methemoglobinemia

Diseases related to Acquired Methemoglobinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 methemoglobinemia 30.3 HBG2 G6PD CYB5R3
2 hemolytic anemia 29.9 HBG2 G6PD
3 glucosephosphate dehydrogenase deficiency 29.7 HBG2 G6PD
4 bilirubin metabolic disorder 29.3 HBG2 G6PD
5 cyanosis, transient neonatal 10.4
6 ocular motor apraxia 10.0
7 cutaneous lupus erythematosus 10.0
8 cystitis 10.0
9 pustulosis of palm and sole 10.0
10 neuropathy 10.0
11 psoriasis 10.0
12 tremor 10.0
13 subacute cutaneous lupus erythematosus 10.0
14 alkaptonuria 9.9
15 methemoglobin reductase deficiency 9.9
16 metabolic acidosis 9.9
17 rheumatic heart disease 9.9
18 respiratory failure 9.9
19 heart disease 9.9
20 theileriasis 9.9
21 pulmonary embolism 9.9
22 posttransplant acute limbic encephalitis 9.9
23 iron deficiency anemia 9.7 HBG2 G6PD
24 deficiency anemia 9.7 HBG2 G6PD
25 hemoglobin h disease 9.7 HBG2 G6PD
26 sickle cell disease 9.7 HBG2 G6PD
27 hereditary spherocytosis 9.6 HBG2 G6PD
28 sickle cell anemia 9.6 HBG2 G6PD
29 alpha-thalassemia 9.6 HBG2 G6PD
30 chronic granulomatous disease 9.5 HBG2 G6PD
31 congenital methemoglobinemia 9.5 HBG2 G6PD CYB5R3
32 congenital hemolytic anemia 9.5 HBG2 G6PD CYB5R3
33 hemoglobinopathy 9.4 HBG2 G6PD CYB5R3
34 beta-thalassemia 9.4 HBG2 G6PD

Graphical network of the top 20 diseases related to Acquired Methemoglobinemia:



Diseases related to Acquired Methemoglobinemia

Symptoms & Phenotypes for Acquired Methemoglobinemia

Human phenotypes related to Acquired Methemoglobinemia:

58 31 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 methemoglobinemia 58 31 hallmark (90%) Very frequent (99-80%) HP:0012119
2 vomiting 58 31 frequent (33%) Frequent (79-30%) HP:0002013
3 fatigue 58 31 frequent (33%) Frequent (79-30%) HP:0012378
4 anxiety 58 31 frequent (33%) Frequent (79-30%) HP:0000739
5 vertigo 58 31 frequent (33%) Frequent (79-30%) HP:0002321
6 headache 58 31 frequent (33%) Frequent (79-30%) HP:0002315
7 hypoxemia 58 31 frequent (33%) Frequent (79-30%) HP:0012418
8 cyanosis 58 31 frequent (33%) Frequent (79-30%) HP:0000961
9 confusion 58 31 frequent (33%) Frequent (79-30%) HP:0001289
10 acidosis 58 31 frequent (33%) Frequent (79-30%) HP:0001941
11 palpitations 58 31 frequent (33%) Frequent (79-30%) HP:0001962
12 abdominal pain 58 31 occasional (7.5%) Occasional (29-5%) HP:0002027
13 syncope 58 31 occasional (7.5%) Occasional (29-5%) HP:0001279
14 tachycardia 58 31 occasional (7.5%) Occasional (29-5%) HP:0001649
15 coma 58 31 occasional (7.5%) Occasional (29-5%) HP:0001259
16 loss of consciousness 58 31 occasional (7.5%) Occasional (29-5%) HP:0007185
17 drowsiness 58 31 occasional (7.5%) Occasional (29-5%) HP:0002329
18 respiratory distress 58 31 very rare (1%) Very rare (<4-1%) HP:0002098
19 seizure 31 very rare (1%) HP:0001250
20 seizures 58 Very rare (<4-1%)
21 dyspnea 58 Frequent (79-30%)
22 arrhythmia 58 Occasional (29-5%)

GenomeRNAi Phenotypes related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.62 G6PD HBG2

Drugs & Therapeutics for Acquired Methemoglobinemia

Drugs for Acquired Methemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 4 61-73-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open Label Clinical Study to Evaluate the Safety and Efficacy of ProvayBlueTM (Methylene Blue) for the Treatment of Acquired Methemoglobinemia Completed NCT03395223 Phase 4 Methylene Blue
2 Use of Methylene Blue in Acquired Methemoglobinemia: Prospective Observational Registry (metHb) Unknown status NCT03542760 Methylene Blue

Search NIH Clinical Center for Acquired Methemoglobinemia

Genetic Tests for Acquired Methemoglobinemia

Anatomical Context for Acquired Methemoglobinemia

Publications for Acquired Methemoglobinemia

Articles related to Acquired Methemoglobinemia:

(show top 50) (show all 132)
# Title Authors PMID Year
1
Heterogeneity of the molecular biology of methemoglobinemia: a study of eight consecutive patients. 54 61
15921385 2005
2
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. 61 54
15342970 2004
3
Metoclopramide-induced methemoglobinemia in an adult. 61 54
10870338 2000
4
Treatment of high-risk, refractory acquired methemoglobinemia with automated red blood cell exchange. 61 54
9590495 1998
5
Acute Acquired Methemoglobinemia Following Nitrobenzene Poisoning. 61
33510533 2021
6
Pediatric Toxidrome Simulation Curriculum: Lidocaine-Induced Methemoglobinemia. 61
33537407 2021
7
Unusual cause of persistent dyspnea in a patient with nephrotic syndrome: dapsone-induced methemoglobinemia. 61
33417185 2021
8
Effect of organo-selenium anticancer drugs on nitrite induced methemoglobinemia: A spectroscopic study. 61
32979808 2021
9
Dapsone-induced methemoglobinemia in pediatrics post-renal transplant. 61
33280223 2020
10
Acquired methemoglobinemia presenting to the pediatric emergency department: a clinical challenge. 61
32396060 2020
11
Methemoglobinemia Unmasked by Use of Sodium Nitroprusside and Hypothermia in a Case of Chronic Thromboembolic Pulmonary Hypertension During Pulmonary Endarterectomy: A Case Report. 61
32985847 2020
12
Unexplained Methemoglobinemia in Coronavirus Disease 2019: A Case Report. 61
32909713 2020
13
Methemoglobinemia: A Life-threatening Complication of Topical Pharyngeal Anesthetics. 61
32494515 2020
14
The Dose Makes the Poison: A Case Report of Acquired Methemoglobinemia. 61
32178428 2020
15
Altered Mental Status and Cyanosis in a Pediatric Patient with Methemoglobinemia. 61
33274100 2020
16
Hospital-acquired methemoglobinemia. 61
33380153 2020
17
Neonatal Acquired Methemoglobinemia - Can Broad Spectrum Antibiotics be Implicated?: Correspondence. 61
31300952 2019
18
Cetirizine as a Causative Agent for Drug Induced Methemoglobinemia: A Case Report and Review. 61
31719817 2019
19
Acquired Methemoglobinemia. 61
31532963 2019
20
Neonatal Acquired Methemoglobinemia - Can Broad Spectrum Antibiotics be Implicated? 61
31111441 2019
21
Exon sequencing of the alpha-2-globin gene for the differential diagnosis of central cyanosis in newborns: a case report. 61
31269924 2019
22
Code Blue: Life-threatening Methemoglobinemia. 61
31061960 2019
23
Methemoglobinemia: Infants at risk. 61
30956100 2019
24
Life-Threatening Extreme Methemoglobinemia during Standard Dose Nitric Oxide Therapy. 61
31454813 2019
25
'Acute leukemia in congenital methehemoglobinemia - an enigma to explore'. 61
30788079 2019
26
Effect of Zamzam water on blood methemoglobin level in young rats. 61
30697102 2019
27
Acquired methemoglobinemia from phenazopyridine use. 61
31179913 2018
28
A Case Report of Benzocaine-Induced Methemoglobinemia. 61
28803519 2018
29
Methemoglobinemia - The Cryptic Cause of Dyspnoea. 61
31321942 2018
30
Letter in response to "Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury". 61
29164951 2018
31
Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury. 61
28969436 2018
32
Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report. 61
29627919 2018
33
A new mutation of congenital methemoglobinemia exacerbated after methylene blue treatment. 61
29657736 2018
34
Methemoglobinemia Following Monolinuron Ingestion: A Case Report in a Child. 61
27253655 2018
35
Role of Automated Therapeutic Red Cell Exchange in the Setting of Acute Methemoglobinemia: Our Experience. 61
29398814 2018
36
Upward trend of dapsone-induced methemoglobinemia in renal transplant community‚Ä©. 61
28699887 2017
37
Plasmapheresis in severe methemoglobinemia following occupational exposure. 61
28259531 2017
38
Acquired Methemoglobinemia - A Sporadic Holi Disaster. 61
28667718 2017
39
Severe methemoglobinemia caused by continuous lidocaine infusion in a term neonate. 61
28082013 2017
40
Central Nervous System Symptoms Due to Transient Methemoglobinemia in a Child With G6PD Deficiency. 61
27879542 2017
41
A 12-Day-Old Boy with Methemoglobinemia After Circumcision with Local Anesthesia (Lidocaine/Prilocaine). 61
27747692 2016
42
Difference of the clinical course and outcome between dapsone-induced methemoglobinemia and other toxic-agent-induced methemoglobinemia. 61
27412886 2016
43
Methemoglobinemia caused by dapsone overdose: Which treatment is best? 61
27239625 2015
44
Visual Diagnosis: A 7-Month-Old Girl With Cyanotic Spells. 61
26430211 2015
45
[Association of benzocaine and paracetamol with neonatal-acquired methemoglobinemia]. 61
29421147 2015
46
Patient with terbinafine-induced subacute cutaneous lupus erythematosus followed by thalidomide-induced orofacial neuropathy; Beta blocker use, hypertension, and the risk of psoriasis; eczematous reaction to intravenous immunoglobulin; nicolau syndrome after intra-articular glucocorticoid injection; troponin leak associated with drug-induced methemoglobinemia. 61
25684795 2015
47
Do all patients with acquired methemoglobinemia need treatment? A lesson learnt. 61
26486118 2015
48
An Atypical Case of Methemoglobinemia due to Self-Administered Benzocaine. 61
25874137 2015
49
P-chloroaniline poisoning causing methemoglobinemia: a case report and review of the literature. 61
25861488 2015
50
Methemoglobinemia due to quinine causing severe acute kidney injury in a child. 61
25484537 2014

Variations for Acquired Methemoglobinemia

Expression for Acquired Methemoglobinemia

Search GEO for disease gene expression data for Acquired Methemoglobinemia.

Pathways for Acquired Methemoglobinemia

Pathways related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.23 G6PD CYB5R3

GO Terms for Acquired Methemoglobinemia

Cellular components related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin complex GO:0005833 8.62 HBG2 CYB5R3

Biological processes related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol biosynthetic process GO:0006695 8.62 G6PD CYB5R3

Sources for Acquired Methemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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