MCID: ACQ047
MIFTS: 27

Acquired Methemoglobinemia

Categories: Blood diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Acquired Methemoglobinemia

MalaCards integrated aliases for Acquired Methemoglobinemia:

Name: Acquired Methemoglobinemia 59 73
Drug-Induced Methemoglobinemia 59 73
Methemoglobinemia Acquired 55

Classifications:



External Ids:

Orphanet 59 ORPHA464453
ICD10 via Orphanet 34 D74.8

Summaries for Acquired Methemoglobinemia

MalaCards based summary : Acquired Methemoglobinemia, also known as drug-induced methemoglobinemia, is related to methemoglobinemia and burns. An important gene associated with Acquired Methemoglobinemia is HBG2 (Hemoglobin Subunit Gamma 2), and among its related pathways/superpathways is Methylene Blue Pathway, Pharmacodynamics. The drug Methylene blue has been mentioned in the context of this disorder. Affiliated tissues include lung and heart, and related phenotype is Increased shRNA abundance.

Related Diseases for Acquired Methemoglobinemia

Diseases in the Methemoglobinemia family:

Methemoglobinemia, Beta Type Methemoglobinemia, Alpha Type
Congenital Methemoglobinemia Hereditary Methemoglobinemia
Acquired Methemoglobinemia

Diseases related to Acquired Methemoglobinemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 14)
# Related Disease Score Top Affiliating Genes
1 methemoglobinemia 29.0 CYB5R3 G6PD HBG2
2 burns 9.9
3 hereditary methemoglobinemia 9.8 CYB5R3 HBG2
4 alkaptonuria 9.7
5 rheumatic heart disease 9.7
6 heart disease 9.7
7 glucosephosphate dehydrogenase deficiency 9.4 G6PD HBG2
8 sickle cell disease 9.4 G6PD HBG2
9 alpha-thalassemia 9.4 G6PD HBG2
10 chronic granulomatous disease 9.3 G6PD HBG2
11 beta-thalassemia 9.2 G6PD HBG2
12 deficiency anemia 9.1 G6PD HBG2
13 congenital methemoglobinemia 8.9 CYB5R3 G6PD HBG2
14 hemolytic anemia 8.9 G6PD HBG2

Graphical network of the top 20 diseases related to Acquired Methemoglobinemia:



Diseases related to Acquired Methemoglobinemia

Symptoms & Phenotypes for Acquired Methemoglobinemia

GenomeRNAi Phenotypes related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.62 G6PD HBG2

Drugs & Therapeutics for Acquired Methemoglobinemia

Drugs for Acquired Methemoglobinemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylene blue Approved, Investigational Phase 4 61-73-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 MEthylene Blue In Patients With Acquired Methemoglobinemia Not yet recruiting NCT03395223 Phase 4 Methylene Blue
2 Acquired Methemoglobinemia Observational Registry Recruiting NCT03542760 Methylene Blue

Search NIH Clinical Center for Acquired Methemoglobinemia

Genetic Tests for Acquired Methemoglobinemia

Anatomical Context for Acquired Methemoglobinemia

MalaCards organs/tissues related to Acquired Methemoglobinemia:

41
Lung, Heart

Publications for Acquired Methemoglobinemia

Articles related to Acquired Methemoglobinemia:

(show all 32)
# Title Authors Year
1
Acquired Methemoglobinemia Associated with Topical Lidocaine Administration: A Case Report. ( 29627919 )
2018
2
Acquired Methemoglobinemia - A Sporadic Holi Disaster. ( 28667718 )
2017
3
Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury. ( 28969436 )
2017
4
Letter in response to "Acquired methemoglobinemia after hydroxocobalamin administration in a patient with burns and inhalation injury". ( 29164951 )
2017
5
Do all patients with acquired methemoglobinemia need treatment? A lesson learnt. ( 26486118 )
2015
6
Patient with terbinafine-induced subacute cutaneous lupus erythematosus followed by thalidomide-induced orofacial neuropathy; Beta blocker use, hypertension, and the risk of psoriasis; eczematous reaction to intravenous immunoglobulin; nicolau syndrome after intra-articular glucocorticoid injection; troponin leak associated with drug-induced methemoglobinemia. ( 25684795 )
2015
7
Understanding acquired methemoglobinemia. ( 24430394 )
2014
8
A rare case of acquired methemoglobinemia associated with alkaptonuria. ( 25130113 )
2014
9
Evaluation and management of acquired methemoglobinemia associated with topical benzocaine use. ( 23696166 )
2013
10
Acquired methemoglobinemia due to contaminated Holi colors - a rare but preventable complication. ( 22700388 )
2013
11
A patient with rheumatic heart disease presented with central cyanosis due to acquired methemoglobinemia during late pregnancy - A rare association. ( 24027374 )
2013
12
Two cases of acquired methemoglobinemia. ( 23136811 )
2012
13
Acquired methemoglobinemia due to application of prilocaine during circumcision. ( 20851555 )
2012
14
Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures. ( 22915889 )
2011
15
Acquired methemoglobinemia in infants. ( 27264127 )
2011
16
[Acquired methemoglobinemia--case report]. ( 20306428 )
2010
17
Acquired methemoglobinemia revisited. ( 20831930 )
2010
18
Acquired methemoglobinemia due to contaminated colours: a preventable disaster. ( 19158164 )
2009
19
Case 1: Chocolate-coloured blood in infant with shock (case presentation). Diagnosis: Acquired methemoglobinemia. ( 18532933 )
2008
20
When brown and blue make red: a case of acquired methemoglobinemia. ( 16701115 )
2006
21
Acquired methemoglobinemia: a retrospective series of 138 cases at 2 teaching hospitals. ( 15342970 )
2004
22
Acquired methemoglobinemia: a rare but serious complication. ( 12971073 )
2003
23
Drug-induced methemoglobinemia during thoracoscopic lung biopsy. ( 11235734 )
2001
24
Acquired methemoglobinemia in anemic cattle infected with Theileria sergenti. ( 11705651 )
2001
25
Acquired methemoglobinemia following benzocaine anesthesia of the pharynx. ( 10800606 )
2000
26
When patients become cyanotic: acquired methemoglobinemia. ( 10377640 )
1999
27
[Congenital and acquired methemoglobinemia and its therapy]. ( 9588101 )
1998
28
Treatment of high-risk, refractory acquired methemoglobinemia with automated red blood cell exchange. ( 9590495 )
1998
29
Acquired methemoglobinemia possibly related to phenazopyridine in a woman with normal renal function. ( 9302157 )
1997
30
Acquired methemoglobinemia from multiple oxidants. ( 8211336 )
1993
31
Drug-induced methemoglobinemia in a healthy 20-year-old soldier undergoing shoulder surgery. ( 8136402 )
1993
32
Acquired methemoglobinemia. The relationship of cause to course of illness. ( 2288611 )
1990

Variations for Acquired Methemoglobinemia

Expression for Acquired Methemoglobinemia

Search GEO for disease gene expression data for Acquired Methemoglobinemia.

Pathways for Acquired Methemoglobinemia

Pathways related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.23 CYB5R3 G6PD

GO Terms for Acquired Methemoglobinemia

Cellular components related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hemoglobin complex GO:0005833 8.62 CYB5R3 HBG2

Biological processes related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipid metabolic process GO:0006629 8.96 CYB5R3 G6PD
2 cholesterol biosynthetic process GO:0006695 8.62 CYB5R3 G6PD

Molecular functions related to Acquired Methemoglobinemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 oxidoreductase activity GO:0016491 8.62 CYB5R3 G6PD

Sources for Acquired Methemoglobinemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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