MCID: ACQ053
MIFTS: 17

Acquired Neutropenia

Categories: Blood diseases, Bone diseases, Cancer diseases, Endocrine diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases
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Aliases & Classifications for Acquired Neutropenia

MalaCards integrated aliases for Acquired Neutropenia:

Name: Acquired Neutropenia 58
Immunologic Neutropenia 58

Classifications:

Orphanet: 58  
Rare immunological diseases


External Ids:

Orphanet 58 ORPHA178996

Summaries for Acquired Neutropenia

MalaCards based summary: Acquired Neutropenia, also known as immunologic neutropenia, is related to neonatal alloimmune neutropenia and neutropenia. The drugs Busulfan and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, kidney and bone.

Related Diseases for Acquired Neutropenia

Graphical network of the top 20 diseases related to Acquired Neutropenia:



Diseases related to Acquired Neutropenia

Symptoms & Phenotypes for Acquired Neutropenia

Drugs & Therapeutics for Acquired Neutropenia

Drugs for Acquired Neutropenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
2
Fludarabine Approved Phase 1, Phase 2 75607-67-9, 21679-14-1 30751 657237
3
Thiotepa Approved, Investigational Phase 1, Phase 2 52-24-4 5453
4 Alkylating Agents Phase 1, Phase 2
5 Antineoplastic Agents, Alkylating Phase 1, Phase 2
6 Antilymphocyte Serum Phase 1, Phase 2
7 Thymoglobulin Phase 1, Phase 2
8 Immunosuppressive Agents Phase 1, Phase 2
9 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 PEDS024, Phase I/II Feasibility Study of Busulfan Fludarabine and Thiotepa Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation (HSCT) for Children With Non-Malignant Disorders Active, not recruiting NCT03513328 Phase 1, Phase 2 Thiotepa--single daily dose;Thiotepa--escalated dose

Search NIH Clinical Center for Acquired Neutropenia

Genetic Tests for Acquired Neutropenia

Anatomical Context for Acquired Neutropenia

Organs/tissues related to Acquired Neutropenia:

MalaCards : Thyroid, Kidney, Bone

Publications for Acquired Neutropenia

Articles related to Acquired Neutropenia:

(show all 31)
# Title Authors PMID Year
1
Clinical Epidemiology Characteristics and Etiology of Febrile Neutropenia in Children: Analysis of 421 Cases. 62
35997401 2022
2
How to Make the Right Diagnosis in Neutropenia. 62
34595466 2021
3
Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients. 62
31383393 2019
4
Quality Comparison of Biosimilar and Copy Filgrastim Products with the Innovator Product. 62
30280277 2018
5
Atraumatic Clostridial Myonecrosis in an Immunocompromised Host. 62
29534840 2018
6
The Infectious and Noninfectious Etiology, Clinical Picture and Outcome of Neutropenia in Immunocompetent Hospitalized Children. 62
29319583 2018
7
Severe Gingival Ulceration and Necrosis Caused by an Antithyroid Drug: One Case Report and Proposed Clinical Approach. 62
32686361 2018
8
[Advances in research on childhood neutropenia]. 62
28407840 2017
9
Autoimmune and other acquired neutropenias. 62
27913460 2016
10
Approach to the patient with neutropenia in childhood. 62
26568688 2015
11
[G-CSF and Its Receptor in Hematonosis]. 62
26117053 2015
12
High Frequency of Thyroid Disorders in Patients Presenting With Neutropenia to an Outpatient Hematology Clinic STROBE-Compliant Article. 62
26061308 2015
13
Autoimmune neutropenia after kidney transplantation: a disregarded entity of posttransplant neutropenia. 62
24598937 2014
14
Transient neutropenia in children with febrile illness and associated infectious agents: 2 years' follow-up. 62
23408310 2013
15
Prevention and control of infections in patients with severe congenital neutropenia; a follow up study. 62
22427476 2012
16
Congenital and acquired neutropenia consensus guidelines on diagnosis from the Neutropenia Committee of the Marrow Failure Syndrome Group of the AIEOP (Associazione Italiana Emato-Oncologia Pediatrica). 62
21448998 2011
17
Severe acquired neutropenia associated with anti-proteinase 3 antibodies. 62
21934294 2011
18
Prolonged acquired neutropenia in children. 62
19711442 2009
19
Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. 62
21082926 2008
20
The clinical significance of non-malignant neutropenia in hospitalized children. 62
17653547 2007
21
Clinical applications of granulocyte-colony stimulating factor. 62
17127437 2007
22
Congenital and acquired neutropenia. 62
15561677 2004
23
[Hematopoietic growth factors in prophylaxis and therapy of infections complications in children with neutropenia]. 62
11528556 2001
24
Granulocyte colony-stimulating factor (G-CSF) induces the production of cytokines in vivo. 62
10792294 2000
25
Invasive pulmonary infection due to Scedosporium apiospermum in two children with chronic granulomatous disease. 62
9868657 1998
26
[Congenital and acquired neutropenia in children]. 62
8685169 1996
27
[Acquired and constitutional neutropenia in children]. 62
7842076 1994
28
Increased bone metabolism in a patient undergoing long-term rhG-CSF treatment for idiopathic acquired neutropenia. 62
7685195 1993
29
Alloimmune neonatal neutropenia: clinical observations and therapeutic consequences. 62
3730181 1986
30
["Immunologic" neutropenia. Inefficacy of high-dose intravenous gamma globulins?]. 62
6190162 1983
31
The Fine page. Drug-induced immunologic neutropenia. 62
730454 1978

Variations for Acquired Neutropenia

Expression for Acquired Neutropenia

Search GEO for disease gene expression data for Acquired Neutropenia.

Pathways for Acquired Neutropenia

GO Terms for Acquired Neutropenia

Sources for Acquired Neutropenia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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