Acquired Neutropenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Aliases & Classifications for Acquired Neutropenia

MalaCards integrated aliases for Acquired Neutropenia:

Name: Acquired Neutropenia ⁵⁸

Immunologic Neutropenia ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Genetic diseases Cancer diseases Infectious diseases
Anatomical: Blood diseases Immune diseases Neuronal diseases Respiratory diseases Bone diseases Endocrine diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare immunological diseases

External Ids:

Orphanet ⁵⁸ ORPHA178996

Sources

Summaries for Acquired Neutropenia

MalaCards based summary: Acquired Neutropenia, also known as immunologic neutropenia, is related to neonatal alloimmune neutropenia and neutropenia. The drugs Busulfan and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include thyroid, kidney and bone.

Sources

Related Diseases for Acquired Neutropenia

Diseases in the Neutropenia family:

Neutropenia, Chronic Familial	Neutropenia, Severe Congenital, 1, Autosomal Dominant
Neutropenia, Severe Congenital, 3, Autosomal Recessive	Neutropenia, Severe Congenital, 4, Autosomal Recessive
Neutropenia, Severe Congenital, 2, Autosomal Dominant	Neutropenia, Severe Congenital, 5, Autosomal Recessive
Neutropenia, Severe Congenital, 6, Autosomal Recessive	Neutropenia, Severe Congenital, 7, Autosomal Recessive
Neutropenia, Severe Congenital, 8, Autosomal Dominant	Neutropenia, Severe Congenital, 9, Autosomal Dominant
Severe Congenital Neutropenia	Severe Congenital Neutropenia 1
Severe Congenital Neutropenia 7	Autosomal Dominant Severe Congenital Neutropenia
Severe Congenital Neutropenia 2	Severe Congenital Neutropenia 5
Severe Congenital Neutropenia 3	Severe Congenital Neutropenia 6
Severe Congenital Neutropenia 8	Severe Congenital Neutropenia 4
Elane-Related Neutropenia	Acquired Neutropenia
Autosomal Recessive Severe Congenital Neutropenia

Diseases related to Acquired Neutropenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)

#	Related Disease	Score
1	neonatal alloimmune neutropenia	11.0
2	neutropenia	10.2
3	severe congenital neutropenia	10.0
4	felty syndrome	9.8
5	cyclic neutropenia	9.8
6	myelodysplastic syndrome	9.8
7	severe congenital neutropenia 3	9.8
8	thrombocytosis	9.8
9	hermansky-pudlak syndrome	9.8
10	collagen disease	9.8
11	granulocytopenia	9.8

Graphical network of the top 20 diseases related to Acquired Neutropenia:

Sources

Symptoms & Phenotypes for Acquired Neutropenia

Sources

Drugs & Therapeutics for Acquired Neutropenia

Drugs for Acquired Neutropenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Busulfan

Approved, Investigational

Phase 1, Phase 2

55-98-1

2478

2

Fludarabine

Approved

Phase 1, Phase 2

75607-67-9, 21679-14-1

30751 657237

3

Thiotepa

Approved, Investigational

Phase 1, Phase 2

52-24-4

5453

4

Alkylating Agents

Phase 1, Phase 2

5

Antineoplastic Agents, Alkylating

Phase 1, Phase 2

6

Antilymphocyte Serum

Phase 1, Phase 2

7

Thymoglobulin

Phase 1, Phase 2

8

Immunosuppressive Agents

Phase 1, Phase 2

9

Immunologic Factors

Phase 1, Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	PEDS024, Phase I/II Feasibility Study of Busulfan Fludarabine and Thiotepa Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation (HSCT) for Children With Non-Malignant Disorders	Active, not recruiting	NCT03513328	Phase 1, Phase 2	Thiotepa--single daily dose;Thiotepa--escalated dose

Search NIH Clinical Center for Acquired Neutropenia

Sources

Genetic Tests for Acquired Neutropenia

Sources

Anatomical Context for Acquired Neutropenia

Organs/tissues related to Acquired Neutropenia:

MalaCards : Thyroid, Kidney, Bone

Sources

Publications for Acquired Neutropenia

Articles related to Acquired Neutropenia:

(show all 31)

#	Title	Authors	PMID	Year
1	Clinical Epidemiology Characteristics and Etiology of Febrile Neutropenia in Children: Analysis of 421 Cases. ⁶²	Nguyen SN...Dinh VTT	35997401	2022
2	How to Make the Right Diagnosis in Neutropenia. ⁶²	Solomou EE...Lagadinou M	34595466	2021
3	Metamizole-associated neutropenia: Comparison of patients with neutropenia and metamizole-tolerant patients. ⁶²	Rudin D...Haschke M	31383393	2019
4	Quality Comparison of Biosimilar and Copy Filgrastim Products with the Innovator Product. ⁶²	Halim LA...Schellekens H	30280277	2018
5	Atraumatic Clostridial Myonecrosis in an Immunocompromised Host. ⁶²	Thompson KM...Hedges MAS	29534840	2018
6	The Infectious and Noninfectious Etiology, Clinical Picture and Outcome of Neutropenia in Immunocompetent Hospitalized Children. ⁶²	David O...Leibovitz E	29319583	2018
7	Severe Gingival Ulceration and Necrosis Caused by an Antithyroid Drug: One Case Report and Proposed Clinical Approach. ⁶²	Chang YY...Yuan K	32686361	2018
8	[Advances in research on childhood neutropenia]. ⁶²	Feng JH...Qian Y	28407840	2017
9	Autoimmune and other acquired neutropenias. ⁶²	Newburger PE	27913460	2016
10	Approach to the patient with neutropenia in childhood. ⁶²	Celkan T...Koc BS	26568688	2015
11	[G-CSF and Its Receptor in Hematonosis]. ⁶²	Zhao SQ...Li JM	26117053	2015
12	High Frequency of Thyroid Disorders in Patients Presenting With Neutropenia to an Outpatient Hematology Clinic STROBE-Compliant Article. ⁶²	Kyritsi EMA...Angelopoulou MK	26061308	2015
13	Autoimmune neutropenia after kidney transplantation: a disregarded entity of posttransplant neutropenia. ⁶²	Aubert O...De Fontbrune FS	24598937	2014
14	Transient neutropenia in children with febrile illness and associated infectious agents: 2 years' follow-up. ⁶²	Alexandropoulou O...Karavanaki K	23408310	2013
15	Prevention and control of infections in patients with severe congenital neutropenia; a follow up study. ⁶²	Salehi T...Moin M	22427476	2012
16	Congenital and acquired neutropenia consensus guidelines on diagnosis from the Neutropenia Committee of the Marrow Failure Syndrome Group of the AIEOP (Associazione Italiana Emato-Oncologia Pediatrica). ⁶²	Fioredda F...Dufour C	21448998	2011
17	Severe acquired neutropenia associated with anti-proteinase 3 antibodies. ⁶²	Loschi M...Jardin F	21934294	2011
18	Prolonged acquired neutropenia in children. ⁶²	Sheen JM...Yang KD	19711442	2009
19	Pathophysiologic mechanisms, clinical features and treatment of idiopathic neutropenia. ⁶²	Papadaki HA...Pontikoglou C	21082926	2008
20	The clinical significance of non-malignant neutropenia in hospitalized children. ⁶²	Vlacha V...Feketea G	17653547	2007
21	Clinical applications of granulocyte-colony stimulating factor. ⁶²	Sung L...Dror Y	17127437	2007
22	Congenital and acquired neutropenia. ⁶²	Berliner N...Loughran TP	15561677	2004
23	[Hematopoietic growth factors in prophylaxis and therapy of infections complications in children with neutropenia]. ⁶²	Lehrnbecher T	11528556	2001
24	Granulocyte colony-stimulating factor (G-CSF) induces the production of cytokines in vivo. ⁶²	Xu S...Venge P	10792294	2000
25	Invasive pulmonary infection due to Scedosporium apiospermum in two children with chronic granulomatous disease. ⁶²	Jabado N...Blanche S	9868657	1998
26	[Congenital and acquired neutropenia in children]. ⁶²	Donadieu J	8685169	1996
27	[Acquired and constitutional neutropenia in children]. ⁶²	Donadieu J...Griscelli C	7842076	1994
28	Increased bone metabolism in a patient undergoing long-term rhG-CSF treatment for idiopathic acquired neutropenia. ⁶²	Woermann UJ...Tobler A	7685195	1993
29	Alloimmune neonatal neutropenia: clinical observations and therapeutic consequences. ⁶²	Hinkel GK...Leverenz S	3730181	1986
30	["Immunologic" neutropenia. Inefficacy of high-dose intravenous gamma globulins?]. ⁶²	Desablens B...Messerschmitt J	6190162	1983
31	The Fine page. Drug-induced immunologic neutropenia. ⁶²	Fine RM	730454	1978

Sources

Genes for Acquired Neutropenia

Sources

Variations for Acquired Neutropenia

Sources

Expression for Acquired Neutropenia

Search GEO for disease gene expression data for Acquired Neutropenia.

Sources

Pathways for Acquired Neutropenia

Sources

GO Terms for Acquired Neutropenia

Sources

Sources for Acquired Neutropenia

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: ACQ053 MIFTS: 17	Acquired Neutropenia Categories: Blood diseases, Bone diseases, Cancer diseases, Endocrine diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
Tissues Related diseases Publications Drugs Expand all tables