Acquired Night Blindness disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Acquired Night Blindness

MalaCards integrated aliases for Acquired Night Blindness:

Name: Acquired Night Blindness ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Eye diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:11491

ICD9CM ³⁴ 368.62

SNOMED-CT ⁶⁷ 53808001

ICD10 ³² H53.62

UMLS ⁷¹ C0152202

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Summaries for Acquired Night Blindness

Disease Ontology : ¹² A nutritional deficiency disease that is characterized by vitamin A deficiency causing poor adaptation of the eyes to low levels of light, and has material basis in lack of vitamin A such that rhodopsin, a light sensitive retinal pigment, cannot be regenerated.

MalaCards based summary : Acquired Night Blindness is related to night blindness and yemenite deaf-blind hypopigmentation syndrome. An important gene associated with Acquired Night Blindness is RCVRN (Recoverin), and among its related pathways/superpathways are Phototransduction and TRP channels. Affiliated tissues include eye, and related phenotype is vision/eye.

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Related Diseases for Acquired Night Blindness

Diseases in the Night Blindness family:

Acquired Night Blindness

Diseases related to Acquired Night Blindness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 28)

#	Related Disease	Score	Top Affiliating Genes
1	night blindness	29.9	TRPM1 KCNV2
2	yemenite deaf-blind hypopigmentation syndrome	10.2
3	hypercarotenemia and vitamin a deficiency, autosomal dominant	10.2
4	keratomalacia	10.2
5	vertebral artery insufficiency	10.0	RGS9BP KCNV2
6	scotoma	9.9	RCVRN KCNV2
7	anorexia nervosa	9.9
8	xerophthalmia	9.9
9	keratoconjunctivitis sicca	9.9
10	nutritional deficiency disease	9.9
11	retinal disease	9.9
12	eating disorder	9.9
13	nephronophthisis 4	9.9	RGS9BP KCNV2
14	cancer-associated retinopathy	9.9	TULP1 RCVRN
15	prolonged electroretinal response suppression	9.9	RGS9BP KCNV2
16	retinitis pigmentosa 7	9.8	TULP1 RGS9BP
17	neuroretinitis	9.8	TRPM1 RCVRN
18	fundus albipunctatus	9.7	TULP1 RGS9BP
19	abnormal threshold of rods	9.7	TRPM1 RGS9BP
20	pathologic nystagmus	9.7	TULP1 KCNV2
21	eye degenerative disease	9.6	TULP1 RCVRN
22	stargardt disease	9.6	TULP1 KCNV2
23	achromatopsia	9.5	TULP1 RGS9BP KCNV2
24	leber plus disease	9.2	TULP1 RGS9BP RCVRN KCNV2
25	inherited retinal disorder	8.8	TULP1 TRPM1 KCNV2
26	congenital stationary night blindness	8.6	TULP1 TRPM3 TRPM1 RGS9BP RCVRN
27	fundus dystrophy	8.6	TULP1 TRPM1 RGS9BP RCVRN KCNV2
28	retinitis pigmentosa	8.5	TULP1 TRPM1 RGS9BP RCVRN KCNV2

Graphical network of the top 20 diseases related to Acquired Night Blindness:

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Symptoms & Phenotypes for Acquired Night Blindness

MGI Mouse Phenotypes related to Acquired Night Blindness:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	vision/eye	MP:0005391	9.02	KCNV2 RCVRN RGS9BP TRPM1 TULP1

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Drugs & Therapeutics for Acquired Night Blindness

Search Clinical Trials , NIH Clinical Center for Acquired Night Blindness

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Genetic Tests for Acquired Night Blindness

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Anatomical Context for Acquired Night Blindness

MalaCards organs/tissues related to Acquired Night Blindness:

⁴⁰

Eye

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Publications for Acquired Night Blindness

Articles related to Acquired Night Blindness:

#	Title	Authors	PMID	Year
1	Acquired night blindness due to bad eating patterns. ⁶¹	Parafita-Fernandez A...Fernandez-Vila PC	25804276	2015
2	Case of acquired night blindness in a hemodialysis patient. ⁶¹	Nishida T...Hayakawa K	24314428	2013
3	Xerophthalmia and acquired night blindness in a patient with a history of gastrointestinal neoplasia and normal serum vitamin A levels. ⁶¹	Anastasakis A...Tsilimbaris MK	23334438	2013
4	Fundus white spots and acquired night blindness due to vitamin A deficiency. ⁶¹	Genead MA...Lindeman M	19809843	2009
5	Acquired unilateral night blindness associated with a negative electroretinogram waveform. ⁶¹	Fishman GA...Derlacki DJ	8628566	1996
6	Paraneoplastic night blindness with malignant melanoma. ⁶¹	Berson EL...Lessell S	2971322	1988

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Genes for Acquired Night Blindness

Genes related to Acquired Night Blindness (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RCVRN	Recoverin	Protein Coding	6.09	DISEASES inferred ¹⁵
2	RGS9BP	Regulator Of G Protein Signaling 9 Binding Protein	Protein Coding	5.82	DISEASES inferred ¹⁵
3	KCNV2	Potassium Voltage-Gated Channel Modifier Subfamily V Member 2	Protein Coding	5.58	DISEASES inferred ¹⁵
4	TULP1	TUB Like Protein 1	Protein Coding	5.11	DISEASES inferred ¹⁵
5	TRPM1	Transient Receptor Potential Cation Channel Subfamily M Member 1	Protein Coding	4.97	DISEASES inferred ¹⁵
6	TRPM3	Transient Receptor Potential Cation Channel Subfamily M Member 3	Protein Coding	4.93	DISEASES inferred ¹⁵

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Variations for Acquired Night Blindness

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Expression for Acquired Night Blindness

Search GEO for disease gene expression data for Acquired Night Blindness.

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Pathways for Acquired Night Blindness

Pathways related to Acquired Night Blindness according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phototransduction ³⁶ Show member pathways Activation of the phototransduction cascade ⁶⁵ Inactivation, recovery and regulation of the phototransduction cascade ⁶⁵ The phototransduction cascade ⁶⁵ Visual signal transduction- Cones ¹ Visual signal transduction- Rods ¹	11.15	RGS9BP RCVRN
2	TRP channels ⁶⁵	10.02	TRPM3 TRPM1

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GO Terms for Acquired Night Blindness

Cellular components related to Acquired Night Blindness according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	photoreceptor inner segment	GO:0001917	8.96	TULP1 RCVRN
2	photoreceptor outer segment	GO:0001750	8.8	TULP1 RGS9BP RCVRN

Biological processes related to Acquired Night Blindness according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ion transport	GO:0006811	9.63	TRPM3 TRPM1 KCNV2
2	transmembrane transport	GO:0055085	9.61	TRPM3 TRPM1 KCNV2
3	calcium ion transmembrane transport	GO:0070588	9.48	TRPM3 TRPM1
4	cation transmembrane transport	GO:0098655	9.4	TRPM3 TRPM1
5	protein tetramerization	GO:0051262	9.37	TRPM3 TRPM1
6	detection of light stimulus involved in visual perception	GO:0050908	9.32	TULP1 RGS9BP
7	cellular response to light stimulus	GO:0071482	9.26	TRPM3 TRPM1
8	response to stimulus	GO:0050896	9.26	TULP1 TRPM1 RGS9BP RCVRN
9	G protein-coupled glutamate receptor signaling pathway	GO:0007216	9.16	TRPM3 TRPM1
10	visual perception	GO:0007601	8.92	TULP1 TRPM1 RGS9BP RCVRN

Molecular functions related to Acquired Night Blindness according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	calcium channel activity	GO:0005262	9.16	TRPM3 TRPM1
2	cation channel activity	GO:0005261	8.96	TRPM3 TRPM1
3	ion channel activity	GO:0005216	8.8	TRPM3 TRPM1 KCNV2

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Sources for Acquired Night Blindness

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³² ICD10

³³ ICD10 via Orphanet

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³⁵ IUPHAR

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³⁷ LifeMap

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

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⁵⁶ OMIM

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⁶¹ PubMed

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

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⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia