MCID: ACQ002
MIFTS: 21

Acquired Night Blindness

Categories: Eye diseases, Metabolic diseases, Neuronal diseases

Aliases & Classifications for Acquired Night Blindness

MalaCards integrated aliases for Acquired Night Blindness:

Name: Acquired Night Blindness 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11491
ICD9CM 34 368.62
SNOMED-CT 67 53808001
ICD10 32 H53.62
UMLS 71 C0152202

Summaries for Acquired Night Blindness

Disease Ontology : 12 A nutritional deficiency disease that is characterized by vitamin A deficiency causing poor adaptation of the eyes to low levels of light, and has material basis in lack of vitamin A such that rhodopsin, a light sensitive retinal pigment, cannot be regenerated.

MalaCards based summary : Acquired Night Blindness is related to night blindness and yemenite deaf-blind hypopigmentation syndrome. An important gene associated with Acquired Night Blindness is RCVRN (Recoverin), and among its related pathways/superpathways are Phototransduction and TRP channels. Affiliated tissues include eye, and related phenotype is vision/eye.

Related Diseases for Acquired Night Blindness

Graphical network of the top 20 diseases related to Acquired Night Blindness:



Diseases related to Acquired Night Blindness

Symptoms & Phenotypes for Acquired Night Blindness

MGI Mouse Phenotypes related to Acquired Night Blindness:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 KCNV2 RCVRN RGS9BP TRPM1 TULP1

Drugs & Therapeutics for Acquired Night Blindness

Search Clinical Trials , NIH Clinical Center for Acquired Night Blindness

Genetic Tests for Acquired Night Blindness

Anatomical Context for Acquired Night Blindness

MalaCards organs/tissues related to Acquired Night Blindness:

40
Eye

Publications for Acquired Night Blindness

Articles related to Acquired Night Blindness:

# Title Authors PMID Year
1
Acquired night blindness due to bad eating patterns. 61
25804276 2015
2
Case of acquired night blindness in a hemodialysis patient. 61
24314428 2013
3
Xerophthalmia and acquired night blindness in a patient with a history of gastrointestinal neoplasia and normal serum vitamin A levels. 61
23334438 2013
4
Fundus white spots and acquired night blindness due to vitamin A deficiency. 61
19809843 2009
5
Acquired unilateral night blindness associated with a negative electroretinogram waveform. 61
8628566 1996
6
Paraneoplastic night blindness with malignant melanoma. 61
2971322 1988

Variations for Acquired Night Blindness

Expression for Acquired Night Blindness

Search GEO for disease gene expression data for Acquired Night Blindness.

Pathways for Acquired Night Blindness

Pathways related to Acquired Night Blindness according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.15 RGS9BP RCVRN
2 10.02 TRPM3 TRPM1

GO Terms for Acquired Night Blindness

Cellular components related to Acquired Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 8.96 TULP1 RCVRN
2 photoreceptor outer segment GO:0001750 8.8 TULP1 RGS9BP RCVRN

Biological processes related to Acquired Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.63 TRPM3 TRPM1 KCNV2
2 transmembrane transport GO:0055085 9.61 TRPM3 TRPM1 KCNV2
3 calcium ion transmembrane transport GO:0070588 9.48 TRPM3 TRPM1
4 cation transmembrane transport GO:0098655 9.4 TRPM3 TRPM1
5 protein tetramerization GO:0051262 9.37 TRPM3 TRPM1
6 detection of light stimulus involved in visual perception GO:0050908 9.32 TULP1 RGS9BP
7 cellular response to light stimulus GO:0071482 9.26 TRPM3 TRPM1
8 response to stimulus GO:0050896 9.26 TULP1 TRPM1 RGS9BP RCVRN
9 G protein-coupled glutamate receptor signaling pathway GO:0007216 9.16 TRPM3 TRPM1
10 visual perception GO:0007601 8.92 TULP1 TRPM1 RGS9BP RCVRN

Molecular functions related to Acquired Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium channel activity GO:0005262 9.16 TRPM3 TRPM1
2 cation channel activity GO:0005261 8.96 TRPM3 TRPM1
3 ion channel activity GO:0005216 8.8 TRPM3 TRPM1 KCNV2

Sources for Acquired Night Blindness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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