MCID: ACQ002
MIFTS: 20

Acquired Night Blindness

Categories: Eye diseases, Metabolic diseases, Neuronal diseases

Aliases & Classifications for Acquired Night Blindness

MalaCards integrated aliases for Acquired Night Blindness:

Name: Acquired Night Blindness 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:11491
ICD9CM 34 368.62
SNOMED-CT 67 53808001
ICD10 32 H53.62
UMLS 71 C0152202

Summaries for Acquired Night Blindness

Disease Ontology : 12 A nutritional deficiency disease that is characterized by vitamin A deficiency causing poor adaptation of the eyes to low levels of light, and has material basis in lack of vitamin A such that rhodopsin, a light sensitive retinal pigment, cannot be regenerated.

MalaCards based summary : Acquired Night Blindness is related to night blindness and retinal disease. An important gene associated with Acquired Night Blindness is RCVRN (Recoverin), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Phototransduction. Related phenotype is vision/eye.

Related Diseases for Acquired Night Blindness

Diseases in the Night Blindness family:

Acquired Night Blindness

Diseases related to Acquired Night Blindness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 night blindness 30.4 NR2E3 KCNV2
2 retinal disease 29.2 TULP1 NR2E3
3 yemenite deaf-blind hypopigmentation syndrome 10.3
4 keratomalacia 10.2
5 anorexia nervosa 10.0
6 xerophthalmia 10.0
7 keratoconjunctivitis sicca 10.0
8 nutritional deficiency disease 10.0
9 eating disorder 10.0
10 nutritional optic neuropathy 9.9 RGS9BP KCNV2
11 vertebral artery insufficiency 9.9 RGS9BP KCNV2
12 scotoma 9.9 RCVRN KCNV2
13 enhanced s-cone syndrome 9.9 RGS9BP NR2E3
14 nephronophthisis 4 9.9 RGS9BP KCNV2
15 cancer-associated retinopathy 9.8 TULP1 RCVRN
16 retinitis pigmentosa 7 9.7 TULP1 RGS9BP
17 prolonged electroretinal response suppression 9.6 RGS9BP NR2E3 KCNV2
18 stargardt disease 1 9.6 TULP1 KCNV2
19 usher syndrome type 2 9.6 TULP1 NR2E3
20 pathologic nystagmus 9.6 TULP1 KCNV2
21 macular dystrophy, dominant cystoid 9.6 TULP1 RCVRN NR2E3
22 eye degenerative disease 9.5 TULP1 RCVRN NR2E3
23 fundus albipunctatus 9.5 TULP1 RGS9BP NR2E3
24 retinal degeneration 9.5 TULP1 RCVRN NR2E3
25 stargardt disease 9.4 TULP1 NR2E3 KCNV2
26 cone dystrophy 9.4 TULP1 NR2E3 KCNV2
27 congenital stationary night blindness 9.3 TULP1 RGS9BP RCVRN NR2E3
28 cone-rod dystrophy 2 9.2 TULP1 NR2E3 KCNV2
29 achromatopsia 9.2 TULP1 RGS9BP NR2E3 KCNV2
30 leber plus disease 9.0 TULP1 RGS9BP RCVRN NR2E3 KCNV2
31 fundus dystrophy 8.9 TULP1 RGS9BP RCVRN NR2E3 KCNV2
32 retinitis pigmentosa 8.9 TULP1 RGS9BP RCVRN NR2E3 KCNV2

Graphical network of the top 20 diseases related to Acquired Night Blindness:



Diseases related to Acquired Night Blindness

Symptoms & Phenotypes for Acquired Night Blindness

MGI Mouse Phenotypes related to Acquired Night Blindness:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 vision/eye MP:0005391 9.02 KCNV2 NR2E3 RCVRN RGS9BP TULP1

Drugs & Therapeutics for Acquired Night Blindness

Search Clinical Trials , NIH Clinical Center for Acquired Night Blindness

Genetic Tests for Acquired Night Blindness

Anatomical Context for Acquired Night Blindness

Publications for Acquired Night Blindness

Articles related to Acquired Night Blindness:

# Title Authors PMID Year
1
Acquired night blindness due to bad eating patterns. 61
25804276 2015
2
Case of acquired night blindness in a hemodialysis patient. 61
24314428 2013
3
Xerophthalmia and acquired night blindness in a patient with a history of gastrointestinal neoplasia and normal serum vitamin A levels. 61
23334438 2013
4
Fundus white spots and acquired night blindness due to vitamin A deficiency. 61
19809843 2009
5
Acquired unilateral night blindness associated with a negative electroretinogram waveform. 61
8628566 1996
6
Paraneoplastic night blindness with malignant melanoma. 61
2971322 1988

Variations for Acquired Night Blindness

Expression for Acquired Night Blindness

Search GEO for disease gene expression data for Acquired Night Blindness.

Pathways for Acquired Night Blindness

GO Terms for Acquired Night Blindness

Cellular components related to Acquired Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 8.96 TULP1 RCVRN
2 photoreceptor outer segment GO:0001750 8.8 TULP1 RGS9BP RCVRN

Biological processes related to Acquired Night Blindness according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retina development in camera-type eye GO:0060041 9.37 TULP1 NR2E3
2 phototransduction GO:0007602 9.32 RCVRN NR2E3
3 detection of light stimulus involved in visual perception GO:0050908 9.26 TULP1 RGS9BP
4 response to stimulus GO:0050896 9.26 TULP1 RGS9BP RCVRN NR2E3
5 eye photoreceptor cell development GO:0042462 9.16 TULP1 NR2E3
6 visual perception GO:0007601 8.92 TULP1 RGS9BP RCVRN NR2E3

Sources for Acquired Night Blindness

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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