Acquired Night Blindness disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Acquired Night Blindness

MalaCards integrated aliases for Acquired Night Blindness:

Name: Acquired Night Blindness ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Metabolic diseases
Anatomical: Eye diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:11491

ICD9CM ³⁴ 368.62

SNOMED-CT ⁶⁷ 53808001

ICD10 ³² H53.62

UMLS ⁷¹ C0152202

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Summaries for Acquired Night Blindness

Disease Ontology : ¹² A nutritional deficiency disease that is characterized by vitamin A deficiency causing poor adaptation of the eyes to low levels of light, and has material basis in lack of vitamin A such that rhodopsin, a light sensitive retinal pigment, cannot be regenerated.

MalaCards based summary : Acquired Night Blindness is related to night blindness and retinal disease. An important gene associated with Acquired Night Blindness is RCVRN (Recoverin), and among its related pathways/superpathways are Metabolism of fat-soluble vitamins and Phototransduction. Related phenotype is vision/eye.

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Related Diseases for Acquired Night Blindness

Diseases in the Night Blindness family:

Acquired Night Blindness

Diseases related to Acquired Night Blindness via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

#	Related Disease	Score	Top Affiliating Genes
1	night blindness	30.4	NR2E3 KCNV2
2	retinal disease	29.2	TULP1 NR2E3
3	yemenite deaf-blind hypopigmentation syndrome	10.3
4	keratomalacia	10.2
5	anorexia nervosa	10.0
6	xerophthalmia	10.0
7	keratoconjunctivitis sicca	10.0
8	nutritional deficiency disease	10.0
9	eating disorder	10.0
10	nutritional optic neuropathy	9.9	RGS9BP KCNV2
11	vertebral artery insufficiency	9.9	RGS9BP KCNV2
12	scotoma	9.9	RCVRN KCNV2
13	enhanced s-cone syndrome	9.9	RGS9BP NR2E3
14	nephronophthisis 4	9.9	RGS9BP KCNV2
15	cancer-associated retinopathy	9.8	TULP1 RCVRN
16	retinitis pigmentosa 7	9.7	TULP1 RGS9BP
17	prolonged electroretinal response suppression	9.6	RGS9BP NR2E3 KCNV2
18	stargardt disease 1	9.6	TULP1 KCNV2
19	usher syndrome type 2	9.6	TULP1 NR2E3
20	pathologic nystagmus	9.6	TULP1 KCNV2
21	macular dystrophy, dominant cystoid	9.6	TULP1 RCVRN NR2E3
22	eye degenerative disease	9.5	TULP1 RCVRN NR2E3
23	fundus albipunctatus	9.5	TULP1 RGS9BP NR2E3
24	retinal degeneration	9.5	TULP1 RCVRN NR2E3
25	stargardt disease	9.4	TULP1 NR2E3 KCNV2
26	cone dystrophy	9.4	TULP1 NR2E3 KCNV2
27	congenital stationary night blindness	9.3	TULP1 RGS9BP RCVRN NR2E3
28	cone-rod dystrophy 2	9.2	TULP1 NR2E3 KCNV2
29	achromatopsia	9.2	TULP1 RGS9BP NR2E3 KCNV2
30	leber plus disease	9.0	TULP1 RGS9BP RCVRN NR2E3 KCNV2
31	fundus dystrophy	8.9	TULP1 RGS9BP RCVRN NR2E3 KCNV2
32	retinitis pigmentosa	8.9	TULP1 RGS9BP RCVRN NR2E3 KCNV2

Graphical network of the top 20 diseases related to Acquired Night Blindness:

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Symptoms & Phenotypes for Acquired Night Blindness

MGI Mouse Phenotypes related to Acquired Night Blindness:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	vision/eye	MP:0005391	9.02	KCNV2 NR2E3 RCVRN RGS9BP TULP1

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Drugs & Therapeutics for Acquired Night Blindness

Search Clinical Trials , NIH Clinical Center for Acquired Night Blindness

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Genetic Tests for Acquired Night Blindness

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Anatomical Context for Acquired Night Blindness

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Publications for Acquired Night Blindness

Articles related to Acquired Night Blindness:

#	Title	Authors	PMID	Year
1	Acquired night blindness due to bad eating patterns. ⁶¹	Parafita-Fernandez A...Fernandez-Vila PC	25804276	2015
2	Case of acquired night blindness in a hemodialysis patient. ⁶¹	Nishida T...Hayakawa K	24314428	2013
3	Xerophthalmia and acquired night blindness in a patient with a history of gastrointestinal neoplasia and normal serum vitamin A levels. ⁶¹	Anastasakis A...Tsilimbaris MK	23334438	2013
4	Fundus white spots and acquired night blindness due to vitamin A deficiency. ⁶¹	Genead MA...Lindeman M	19809843	2009
5	Acquired unilateral night blindness associated with a negative electroretinogram waveform. ⁶¹	Fishman GA...Derlacki DJ	8628566	1996
6	Paraneoplastic night blindness with malignant melanoma. ⁶¹	Berson EL...Lessell S	2971322	1988

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Genes for Acquired Night Blindness

Genes related to Acquired Night Blindness (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RCVRN	Recoverin	Protein Coding	6.02	DISEASES inferred ¹⁵
2	RGS9BP	Regulator Of G Protein Signaling 9 Binding Protein	Protein Coding	5.76	DISEASES inferred ¹⁵
3	KCNV2	Potassium Voltage-Gated Channel Modifier Subfamily V Member 2	Protein Coding	5.51	DISEASES inferred ¹⁵
4	TULP1	TUB Like Protein 1	Protein Coding	5.05	DISEASES inferred ¹⁵
5	NR2E3	Nuclear Receptor Subfamily 2 Group E Member 3	Protein Coding	4.88	DISEASES inferred ¹⁵

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Variations for Acquired Night Blindness

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Expression for Acquired Night Blindness

Search GEO for disease gene expression data for Acquired Night Blindness.

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Pathways for Acquired Night Blindness

Pathways related to Acquired Night Blindness according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Metabolism of fat-soluble vitamins ⁶⁵ Show member pathways Metabolism of vitamin K ⁶⁵ Retinoid metabolism and transport ⁶⁵ The retinoid cycle in cones (daylight vision) ⁶⁵ Visual phototransduction ⁶⁵ Vitamin D (calciferol) metabolism ⁶⁵	11.29	RGS9BP RCVRN
2	Phototransduction ³⁶ Show member pathways Activation of the phototransduction cascade ⁶⁵ Inactivation, recovery and regulation of the phototransduction cascade ⁶⁵ The phototransduction cascade ⁶⁵ Visual signal transduction- Cones ¹ Visual signal transduction- Rods ¹	10.82	RGS9BP RCVRN

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GO Terms for Acquired Night Blindness

Cellular components related to Acquired Night Blindness according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	photoreceptor inner segment	GO:0001917	8.96	TULP1 RCVRN
2	photoreceptor outer segment	GO:0001750	8.8	TULP1 RGS9BP RCVRN

Biological processes related to Acquired Night Blindness according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	retina development in camera-type eye	GO:0060041	9.37	TULP1 NR2E3
2	phototransduction	GO:0007602	9.32	RCVRN NR2E3
3	detection of light stimulus involved in visual perception	GO:0050908	9.26	TULP1 RGS9BP
4	response to stimulus	GO:0050896	9.26	TULP1 RGS9BP RCVRN NR2E3
5	eye photoreceptor cell development	GO:0042462	9.16	TULP1 NR2E3
6	visual perception	GO:0007601	8.92	TULP1 RGS9BP RCVRN NR2E3

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Sources for Acquired Night Blindness

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Mar-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia