MCID: ACQ010
MIFTS: 39

Acquired Polycythemia

Categories: Blood diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acquired Polycythemia

Summaries for Acquired Polycythemia

MalaCards based summary : Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and polycythemia vera. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Development Angiotensin activation of ERK. The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and lung, and related phenotypes are obesity and hypertension

Related Diseases for Acquired Polycythemia

Diseases in the Polycythemia family:

Primary Polycythemia Acquired Polycythemia
Polycythemia Due to Hypoxia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 polycythemia 30.3 EPO EPOR JAK2
2 polycythemia vera 29.9 EPO EPOR JAK2
3 hemangioblastoma 29.5 EPO EPOR
4 bone marrow cancer 29.3 EPO EPOR JAK2
5 deficiency anemia 29.2 EPO EPOR
6 autosomal recessive secondary polycythemia not associated with vhl gene 12.3
7 autosomal dominant secondary polycythemia 12.3
8 erythropoietin polycythemia 11.3
9 erythrocytosis, familial, 2 10.1 EPO EPOR
10 neonatal anemia 10.1 EPO EPOR
11 erythroleukemia, familial 10.1 EPO EPOR
12 retinitis pigmentosa and erythrocytic microcytosis 10.1 EPO JAK2
13 ewing's family of tumors 10.1 EPO EPOR
14 refractory anemia 10.0 EPO JAK2
15 anemia of prematurity 10.0 EPO EPOR
16 renal cell carcinoma, nonpapillary 10.0
17 splenomegaly 10.0 EPO JAK2
18 respiratory failure 10.0
19 microcytic anemia 9.9 ACO1 EPO
20 pheochromocytoma 9.9
21 membranous nephropathy 9.9
22 arteriovenous fistula 9.9
23 hemangioma 9.9
24 pulmonary emphysema 9.9
25 thrombosis 9.9
26 lung disease 9.9
27 pulmonary arterio-veinous fistula 9.9
28 thrombocytosis 9.9 EPO JAK2
29 erythrocytosis, familial, 1 9.8 EPO EPOR JAK2
30 primary polycythemia 9.8 EPO EPOR JAK2
31 essential thrombocythemia 9.8 EPO EPOR JAK2
32 apnea, obstructive sleep 9.7
33 congenital anomalies of kidney and urinary tract 2 9.7
34 thrombophilia due to thrombin defect 9.7
35 wilms tumor 1 9.7
36 myelofibrosis 9.7
37 myeloma, multiple 9.7
38 aging 9.7
39 pulmonary disease, chronic obstructive 9.7
40 patent ductus arteriosus 1 9.7
41 angina pectoris 9.7
42 glomerulonephritis 9.7
43 leukemia 9.7
44 sleep apnea 9.7
45 lymphoma 9.7
46 hydronephrosis 9.7
47 sarcoma 9.7
48 heart disease 9.7
49 iron deficiency anemia 9.7
50 nephrotic syndrome 9.7

Comorbidity relations with Acquired Polycythemia via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to Acquired Polycythemia

Symptoms & Phenotypes for Acquired Polycythemia

Human phenotypes related to Acquired Polycythemia:

33 (show all 15)
# Description HPO Frequency HPO Source Accession
1 obesity 33 hallmark (90%) HP:0001513
2 hypertension 33 hallmark (90%) HP:0000822
3 hypotension 33 hallmark (90%) HP:0002615
4 acrocyanosis 33 hallmark (90%) HP:0001063
5 venous thrombosis 33 hallmark (90%) HP:0004936
6 visceral angiomatosis 33 hallmark (90%) HP:0100761
7 headache 33 hallmark (90%) HP:0002315
8 erythema 33 hallmark (90%) HP:0010783
9 stroke 33 hallmark (90%) HP:0001297
10 arterial thrombosis 33 hallmark (90%) HP:0004420
11 lethargy 33 hallmark (90%) HP:0001254
12 venous insufficiency 33 hallmark (90%) HP:0005293
13 gastrointestinal infarctions 33 hallmark (90%) HP:0005244
14 abnormal leukocyte morphology 33 hallmark (90%) HP:0001881
15 clubbing 33 frequent (33%) HP:0001217

MGI Mouse Phenotypes related to Acquired Polycythemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.26 EGLN2 EPO EPOR JAK2
2 liver/biliary system MP:0005370 8.92 EGLN2 EPO EPOR JAK2

Drugs & Therapeutics for Acquired Polycythemia

Drugs for Acquired Polycythemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved, Experimental Not Applicable 7439-89-6, 15438-31-0 27284 23925

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Umbilical Cord Clamping Time in the Newborn Completed NCT03624335 Not Applicable
2 CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primitive and Secondary Polycythemia Not yet recruiting NCT03008642 Not Applicable

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

Anatomical Context for Acquired Polycythemia

MalaCards organs/tissues related to Acquired Polycythemia:

42
Kidney, Bone, Lung, Bone Marrow, Endothelial, Testes, T Cells

Publications for Acquired Polycythemia

Articles related to Acquired Polycythemia:

(show top 50) (show all 83)
# Title Authors Year
1
Secondary polycythemia in a sarcoma patient: a commentary about cediranib. ( 30853801 )
2019
2
Association of subcutaneous testosterone pellet therapy with developing secondary polycythemia. ( 29205178 )
2018
3
Severe Secondary Polycythemia in a Female-to-Male Transgender Patient While Using Lifelong Hormonal Therapy: A Patient's Perspective. ( 29396819 )
2018
4
Ischemic Stroke Caused by Secondary Polycythemia and Incidentally-Found Renal Cell Carcinoma: A Case Report. ( 29861497 )
2018
5
Case: Secondary polycythemia due to pazopanib in patients with metastatic renal cell carcinoma. ( 29072563 )
2017
6
A Comparison of Secondary Polycythemia in Hypogonadal Men Treated with Clomiphene Citrate versus Testosterone Replacement: A Multi-Institutional Study. ( 27984109 )
2017
7
Cerebral venous thrombosis and secondary polycythemia in a case of nephrotic syndrome. ( 26997397 )
2016
8
[Inherited primitive and secondary polycythemia]. ( 26827274 )
2016
9
Symptomatic Secondary Polycythemia Induced by Anti-VEGF Therapy for the Treatment of Metastatic Renal Cell Carcinoma: A Case Series and Review. ( 26303589 )
2015
10
Bilateral renal T-cell lymphoma with hepatic infiltration and secondary polycythemia in a dog: Utility of cytology slides. ( 26663927 )
2015
11
Obstructive sleep apnea syndrome and secondary polycythemia: analysis of the nationwide inpatient sample. ( 25534581 )
2015
12
Secondary polycythemia and the risk of venous thromboembolism. ( 25110547 )
2014
13
Leukemia kidney infiltration can cause secondary polycythemia by activating hypoxia-inducible factor (HIF) pathway. ( 23677251 )
2013
14
Prevalence of venous thromboembolism in patients with secondary polycythemia. ( 23007895 )
2013
15
A classification system based on a new wrapper feature selection algorithm for the diagnosis of primary and secondary polycythemia. ( 24290929 )
2013
16
Left main coronary thrombotic occlusion due to secondary polycythemia in a normal sinus of valsalva. ( 23913610 )
2013
17
Pulmonary embolism in chronic hypoxemic patients with and without secondary polycythemia--analysis of risk factors in prospective clinical study. ( 23892842 )
2013
18
Sporadic CNS hemangioblastomatosis, response to sunitinib and secondary polycythemia. ( 22076450 )
2012
19
Coexistence of a myeloproliferative disorder and secondary polycythemia in the same patient. ( 22473461 )
2012
20
Images in clinical medicine. Nonobstructive hydronephrosis with secondary polycythemia. ( 21732830 )
2011
21
Hookah (narghile) smoking: a new emerging cause of secondary polycythemia. ( 21761441 )
2011
22
Spontaneous aortic thrombosis causing left main coronary occlusion in a man with secondary polycythemia. ( 21851910 )
2011
23
Phlebotomy for rapid weaning and extubation in COPD patient with secondary polycythemia and respiratory failure. ( 20539767 )
2010
24
Novel somatic mutations of the VHL gene in an erythropoietin-producing renal carcinoma associated with secondary polycythemia and elevated circulating endothelial progenitor cells. ( 17696210 )
2008
25
Secondary polycythemia caused by ureteropelvic junction obstruction successfully treated by laparoscopic nephrectomy. ( 16750248 )
2006
26
You're the flight surgeon: mesangiocapillary glomerulonephritis (MPGN) with secondary polycythemia. ( 16313149 )
2005
27
Secondary polycythemia as a paraneoplastic syndrome of testicular seminoma. ( 12923663 )
2004
28
Portal-hypertensive-gastropathy-like changes in a patient with secondary polycythemia: reversal of endoscopic and histopathologic changes with phlebotomy. ( 15173815 )
2004
29
Homozygous hemoglobin Tak causes symptomatic secondary polycythemia in a Thai boy. ( 12621249 )
2003
30
Paradoxical secondary polycythemia in von Hippel-Lindau patients treated with anti-vascular endothelial growth factor receptor therapy. ( 11986247 )
2002
31
Secondary polycythemia associated with idiopathic membranous nephropathy. ( 10970991 )
2000
32
Polycythemia vera megakaryocytes store and release lysozyme to a higher extent than megakaryocytes in secondary polycythemia (polyglobuly). ( 10071085 )
1999
33
Erythropoietin mRNA in hepatocellular carcinomas and kidney in male B6C3F1 mice with secondary polycythemia. ( 9789956 )
1998
34
Polyuria and polydipsia and disturbed vasopressin release in 2 dogs with secondary polycythemia. ( 9348498 )
1997
35
Secondary polycythemia in male B6C3F1 mice with spontaneously occurring hepatocellular carcinomas. ( 9323843 )
1997
36
In vitro sensitivity of human erythroid progenitors to hemopoietic growth factors: studies on primary and secondary polycythemia. ( 7806084 )
1994
37
Giant uterine fibromyoma producing secondary polycythemia. ( 9205464 )
1994
38
Effects of phlebotomy on a patient with secondary polycythemia and angina pectoris. ( 8045664 )
1994
39
Markedly decreased coronary blood flow in secondary polycythemia. ( 1736590 )
1992
40
Immunohistochemical study of erythropoietin in cerebellar hemangioblastomas associated with secondary polycythemia. ( 1994278 )
1991
41
Secondary polycythemia does not increase the risk of perioperative hemorrhagic or thrombotic complications. ( 2039651 )
1991
42
Secondary polycythemia associated with membranous nephropathy. ( 2182232 )
1990
43
Secondary polycythemia associated with multiple myeloma. ( 2739150 )
1989
44
Erythropoietin-induced secondary polycythemia in a patient with a renal cell carcinoma. A case report. ( 3046641 )
1988
45
Control of breathing in patients with chronic obstructive lung diseases and secondary polycythemia after venesection. ( 3715211 )
1986
46
Secondary polycythemia: a boon or a burden? ( 6543649 )
1984
47
Nephroblastoma with secondary polycythemia in a New Zealand white rabbit. ( 6285079 )
1982
48
Cigarette smoking and secondary polycythemia in hypoxic cor pulmonale. ( 7081807 )
1982
49
Optimal hematocrit and blood viscosity in secondary polycythemia as determined from cerebral blood flow. ( 7285399 )
1981
50
Effects of isovolumetric venesection on blood viscosity, on red cell deformability, and on arterial flow velocity in chronic respiratory failure with secondary polycythemia. ( 7313342 )
1981

Variations for Acquired Polycythemia

Expression for Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for Acquired Polycythemia

Pathways related to Acquired Polycythemia according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 EPO EPOR JAK2
2
Show member pathways
12.47 EPO EPOR JAK2
3
Show member pathways
12.35 EPO EPOR JAK2
4 12.28 EGLN2 EPO EPOR JAK2
5
Show member pathways
11.97 EPO EPOR JAK2
6
Show member pathways
11.7 EPO EPOR JAK2
7 11.51 EGLN2 EPO
8 11.48 EPO EPOR
9 11.28 EPO EPOR JAK2
10 11.19 EGLN2 EPO
11
Show member pathways
11.12 EPO EPOR JAK2
12 10.94 EGLN2 EPO
13 10.8 EPO EPOR
14
Show member pathways
10.44 EPO EPOR JAK2

GO Terms for Acquired Polycythemia

Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 EPO JAK2
2 erythrocyte differentiation GO:0030218 9.16 EPO JAK2
3 regulation of transcription from RNA polymerase II promoter in response to hypoxia GO:0061418 8.96 EGLN2 EPO
4 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Sources for Acquired Polycythemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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