MCID: ACQ010
MIFTS: 43

Acquired Polycythemia

Categories: Blood diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acquired Polycythemia

Summaries for Acquired Polycythemia

MalaCards based summary : Acquired Polycythemia, also known as secondary polycythemia, is related to polycythemia and polycythemia vera. An important gene associated with Acquired Polycythemia is EPO (Erythropoietin), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Pathways in cancer. The drug Iron has been mentioned in the context of this disorder. Affiliated tissues include bone, lung and kidney, and related phenotypes are obesity and hypertension

Related Diseases for Acquired Polycythemia

Diseases in the Polycythemia family:

Primary Polycythemia Acquired Polycythemia
Polycythemia Due to Hypoxia Autosomal Dominant Secondary Polycythemia

Diseases related to Acquired Polycythemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 78)
# Related Disease Score Top Affiliating Genes
1 polycythemia 30.3 EPO EPOR JAK2
2 polycythemia vera 30.0 EPO EPOR JAK2
3 hemangioblastoma 29.7 EPO EPOR
4 iron metabolism disease 29.7 EPO TF
5 iron deficiency anemia 29.6 EPO TF
6 deficiency anemia 29.4 EPO EPOR TF
7 autosomal recessive secondary polycythemia not associated with vhl gene 12.3
8 autosomal dominant secondary polycythemia 12.2
9 erythropoietin polycythemia 11.2
10 erythrocytosis, familial, 2 10.1 EPO EPOR
11 neonatal anemia 10.1 EPO EPOR
12 erythroleukemia, familial 10.1 EPO EPOR
13 ewing's family of tumors 10.1 EPO EPOR
14 anemia of prematurity 10.1 EPO EPOR
15 retinitis pigmentosa and erythrocytic microcytosis 10.1 EPO JAK2
16 folic acid deficiency anemia 10.1 EPO TF
17 refractory anemia 10.1 EPO JAK2
18 plethora of newborn 10.1 EPO TF
19 pure red-cell aplasia 10.1 EPO TF
20 splenomegaly 10.1 EPO JAK2
21 analbuminemia 10.1 EPO TF
22 vitamin b12 deficiency 10.1 EPO TF
23 hemosiderosis 10.1 EPO TF
24 hemoglobin h disease 10.1 EPO TF
25 hemoglobinopathy 10.0 EPO TF
26 atransferrinemia 10.0 EPOR TF
27 thrombocytosis 10.0 EPO JAK2
28 nutritional deficiency disease 10.0 EPO TF
29 congenital hemolytic anemia 10.0 EPO TF
30 end stage renal failure 10.0 EPO TF
31 renal cell carcinoma, nonpapillary 10.0
32 uremia 10.0 EPO TF
33 urinary system disease 10.0 EPO TF
34 thalassemia 10.0 EPO TF
35 respiratory failure 9.9
36 beta-thalassemia 9.9 EPO TF
37 erythrocytosis, familial, 1 9.9 EPO EPOR JAK2
38 primary polycythemia 9.9 EPO EPOR JAK2
39 bone marrow cancer 9.9 EPO EPOR JAK2
40 essential thrombocythemia 9.9 EPO EPOR JAK2
41 chronic kidney failure 9.9 EPO EPOR TF
42 restless legs syndrome 9.9 ACO1 EPO
43 microcytic anemia 9.9 ACO1 EPO TF
44 membranous nephropathy 9.9
45 arteriovenous fistula 9.9
46 hemangioma 9.9
47 pulmonary emphysema 9.9
48 thrombosis 9.9
49 pulmonary arterio-veinous fistula 9.9
50 hemochromatosis, type 1 9.8 ACO1 TF

Comorbidity relations with Acquired Polycythemia via Phenotypic Disease Network (PDN):


Bronchitis Chronic Pulmonary Heart Disease
Familial Atrial Fibrillation Heart Disease
Hypertension, Essential Postinflammatory Pulmonary Fibrosis
Primary Polycythemia Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Polycythemia:



Diseases related to Acquired Polycythemia

Symptoms & Phenotypes for Acquired Polycythemia

Human phenotypes related to Acquired Polycythemia:

32 (show all 15)
# Description HPO Frequency HPO Source Accession
1 obesity 32 hallmark (90%) HP:0001513
2 hypertension 32 hallmark (90%) HP:0000822
3 hypotension 32 hallmark (90%) HP:0002615
4 acrocyanosis 32 hallmark (90%) HP:0001063
5 venous thrombosis 32 hallmark (90%) HP:0004936
6 visceral angiomatosis 32 hallmark (90%) HP:0100761
7 erythema 32 hallmark (90%) HP:0010783
8 stroke 32 hallmark (90%) HP:0001297
9 arterial thrombosis 32 hallmark (90%) HP:0004420
10 lethargy 32 hallmark (90%) HP:0001254
11 headache 32 hallmark (90%) HP:0002315
12 venous insufficiency 32 hallmark (90%) HP:0005293
13 gastrointestinal infarctions 32 hallmark (90%) HP:0005244
14 clubbing 32 frequent (33%) HP:0001217
15 abnormal leukocyte morphology 32 hallmark (90%) HP:0001881

MGI Mouse Phenotypes related to Acquired Polycythemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.73 ACO1 EPO EPOR JAK2 SLC2A9 TF
2 liver/biliary system MP:0005370 9.46 EPO EPOR JAK2 SLC2A9
3 mortality/aging MP:0010768 9.43 ACO1 EPO EPOR JAK2 SLC2A9 TF
4 normal MP:0002873 9.02 ACO1 EPO EPOR JAK2 SLC2A9

Drugs & Therapeutics for Acquired Polycythemia

Drugs for Acquired Polycythemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iron Approved Not Applicable 7439-89-6 23925

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Influence of Umbilical Cord Clamping Time in the Newborn Completed NCT03624335 Not Applicable
2 CO-Rebreathing in Comparison to Isotopic Red Cell Volume Determination in the Diagnosis of Primitive and Secondary Polycythemia Not yet recruiting NCT03008642 Not Applicable

Search NIH Clinical Center for Acquired Polycythemia

Genetic Tests for Acquired Polycythemia

Anatomical Context for Acquired Polycythemia

MalaCards organs/tissues related to Acquired Polycythemia:

41
Bone, Lung, Kidney, Endothelial, Bone Marrow, Testes, T Cells

Publications for Acquired Polycythemia

Articles related to Acquired Polycythemia:

(show top 50) (show all 82)
# Title Authors Year
1
Severe Secondary Polycythemia in a Female-to-Male Transgender Patient While Using Lifelong Hormonal Therapy: A Patient's Perspective. ( 29396819 )
2018
2
Ischemic Stroke Caused by Secondary Polycythemia and Incidentally-Found Renal Cell Carcinoma: A Case Report. ( 29861497 )
2018
3
Association of subcutaneous testosterone pellet therapy with developing secondary polycythemia. ( 29205178 )
2017
4
Case: Secondary polycythemia due to pazopanib in patients with metastatic renal cell carcinoma. ( 29072563 )
2017
5
A Comparison of Secondary Polycythemia in Hypogonadal MenA Treated with Clomiphene Citrate versus Testosterone Replacement: A Multi-institutional Study. ( 27984109 )
2016
6
[Inherited primitive and secondary polycythemia]. ( 26827274 )
2016
7
Cerebral venous thrombosis and secondary polycythemia in a case of nephrotic syndrome. ( 26997397 )
2016
8
Obstructive sleep apnea syndrome and secondary polycythemia: analysis of the nationwide inpatient sample. ( 25534581 )
2015
9
Symptomatic Secondary Polycythemia Induced by Anti-VEGF Therapy for the Treatment of Metastatic Renal Cell Carcinoma: A Case Series and Review. ( 26303589 )
2015
10
Bilateral renal T-cell lymphoma with hepatic infiltration and secondary polycythemia in a dog: Utility of cytology slides. ( 26663927 )
2015
11
Secondary polycythemia and the risk of venous thromboembolism. ( 25110547 )
2014
12
Leukemia kidney infiltration can cause secondary polycythemia by activating hypoxia-inducible factor (HIF) pathway. ( 23677251 )
2013
13
Pulmonary embolism in chronic hypoxemic patients with and without secondary polycythemia--analysis of risk factors in prospective clinical study. ( 23892842 )
2013
14
Left main coronary thrombotic occlusion due to secondary polycythemia in a normal sinus of valsalva. ( 23913610 )
2013
15
Prevalence of venous thromboembolism in patients with secondary polycythemia. ( 23007895 )
2013
16
A classification system based on a new wrapper feature selection algorithm for the diagnosis of primary and secondary polycythemia. ( 24290929 )
2013
17
Coexistence of a myeloproliferative disorder and secondary polycythemia in the same patient. ( 22473461 )
2012
18
Sporadic CNS hemangioblastomatosis, response to sunitinib and secondary polycythemia. ( 22076450 )
2012
19
Images in clinical medicine. Nonobstructive hydronephrosis with secondary polycythemia. ( 21732830 )
2011
20
Spontaneous aortic thrombosis causing left main coronary occlusion in a man with secondary polycythemia. ( 21851910 )
2011
21
Hookah (narghile) smoking: a new emerging cause of secondary polycythemia. ( 21761441 )
2011
22
Phlebotomy for rapid weaning and extubation in COPD patient with secondary polycythemia and respiratory failure. ( 20539767 )
2010
23
Novel somatic mutations of the VHL gene in an erythropoietin-producing renal carcinoma associated with secondary polycythemia and elevated circulating endothelial progenitor cells. ( 17696210 )
2008
24
Secondary polycythemia caused by ureteropelvic junction obstruction successfully treated by laparoscopic nephrectomy. ( 16750248 )
2006
25
You're the flight surgeon: mesangiocapillary glomerulonephritis (MPGN) with secondary polycythemia. ( 16313149 )
2005
26
Secondary polycythemia as a paraneoplastic syndrome of testicular seminoma. ( 12923663 )
2004
27
Portal-hypertensive-gastropathy-like changes in a patient with secondary polycythemia: reversal of endoscopic and histopathologic changes with phlebotomy. ( 15173815 )
2004
28
Homozygous hemoglobin Tak causes symptomatic secondary polycythemia in a Thai boy. ( 12621249 )
2003
29
Paradoxical secondary polycythemia in von Hippel-Lindau patients treated with anti-vascular endothelial growth factor receptor therapy. ( 11986247 )
2002
30
Secondary polycythemia associated with idiopathic membranous nephropathy. ( 10970991 )
2000
31
Polycythemia vera megakaryocytes store and release lysozyme to a higher extent than megakaryocytes in secondary polycythemia (polyglobuly). ( 10071085 )
1999
32
Erythropoietin mRNA in hepatocellular carcinomas and kidney in male B6C3F1 mice with secondary polycythemia. ( 9789956 )
1998
33
Secondary polycythemia in male B6C3F1 mice with spontaneously occurring hepatocellular carcinomas. ( 9323843 )
1997
34
Polyuria and polydipsia and disturbed vasopressin release in 2 dogs with secondary polycythemia. ( 9348498 )
1997
35
Giant uterine fibromyoma producing secondary polycythemia. ( 9205464 )
1994
36
In vitro sensitivity of human erythroid progenitors to hemopoietic growth factors: studies on primary and secondary polycythemia. ( 7806084 )
1994
37
Effects of phlebotomy on a patient with secondary polycythemia and angina pectoris. ( 8045664 )
1994
38
Markedly decreased coronary blood flow in secondary polycythemia. ( 1736590 )
1992
39
Immunohistochemical study of erythropoietin in cerebellar hemangioblastomas associated with secondary polycythemia. ( 1994278 )
1991
40
Secondary polycythemia does not increase the risk of perioperative hemorrhagic or thrombotic complications. ( 2039651 )
1991
41
Secondary polycythemia associated with membranous nephropathy. ( 2182232 )
1990
42
Secondary polycythemia associated with multiple myeloma. ( 2739150 )
1989
43
Erythropoietin-induced secondary polycythemia in a patient with a renal cell carcinoma. A case report. ( 3046641 )
1988
44
Control of breathing in patients with chronic obstructive lung diseases and secondary polycythemia after venesection. ( 3715211 )
1986
45
Secondary polycythemia: a boon or a burden? ( 6543649 )
1984
46
Nephroblastoma with secondary polycythemia in a New Zealand white rabbit. ( 6285079 )
1982
47
Cigarette smoking and secondary polycythemia in hypoxic cor pulmonale. ( 7081807 )
1982
48
Optimal hematocrit and blood viscosity in secondary polycythemia as determined from cerebral blood flow. ( 7285399 )
1981
49
Effects of isovolumetric venesection on blood viscosity, on red cell deformability, and on arterial flow velocity in chronic respiratory failure with secondary polycythemia. ( 7313342 )
1981
50
Electrophysiological study of peripheral nerves in secondary polycythemia. ( 6250979 )
1980

Variations for Acquired Polycythemia

Expression for Acquired Polycythemia

Search GEO for disease gene expression data for Acquired Polycythemia.

Pathways for Acquired Polycythemia

GO Terms for Acquired Polycythemia

Biological processes related to Acquired Polycythemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.26 EPO JAK2
2 cellular iron ion homeostasis GO:0006879 9.16 ACO1 TF
3 erythrocyte differentiation GO:0030218 8.96 EPO JAK2
4 erythropoietin-mediated signaling pathway GO:0038162 8.62 EPO EPOR

Sources for Acquired Polycythemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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