MCID: ACQ039
MIFTS: 18

Acquired Purpura Fulminans

Categories: Blood diseases, Rare diseases, Skin diseases
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Aliases & Classifications for Acquired Purpura Fulminans

MalaCards integrated aliases for Acquired Purpura Fulminans:

Name: Acquired Purpura Fulminans 58

Characteristics:


Age Of Onset:

Infancy,Neonatal 58

Age Of Death:

early childhood 58

Classifications:

Orphanet: 58  
Rare haematological diseases


External Ids:

MESH via Orphanet 44 D014884 D055665
ICD10 via Orphanet 32 D65
UMLS via Orphanet 72 C0043068 C0085650
Orphanet 58 ORPHA49566

Summaries for Acquired Purpura Fulminans

Orphanet: 58 A life-threatening, rapidly progressive thrombotic disorder affecting mainly neonates and children that is characterized by purpuric skin lesions and disseminated intravascular coagulation. It may progress rapidly to multi-organ failure caused by thrombotic occlusion of small and medium-sized blood vessels. There are two forms of the disorder that are classified according to triggering mechanisms: acute infectious (the most common form), and idiopathic purpura fulminans.

MalaCards based summary: Acquired Purpura Fulminans is related to purpura fulminans and purpura. Affiliated tissues include skin, and related phenotypes are acrocyanosis and thrombocytopenia

Related Diseases for Acquired Purpura Fulminans

Diseases in the Purpura Fulminans family:

Acquired Purpura Fulminans

Diseases related to Acquired Purpura Fulminans via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 purpura fulminans 10.4
2 purpura 10.4
3 disseminated intravascular coagulation 10.2
4 alcohol dependence 10.0
5 exanthem 10.0
6 vitamin k deficiency bleeding 10.0
7 alcohol use disorder 10.0
8 viral exanthem 10.0
9 meningococcemia 10.0

Graphical network of the top 20 diseases related to Acquired Purpura Fulminans:



Diseases related to Acquired Purpura Fulminans

Symptoms & Phenotypes for Acquired Purpura Fulminans

Human phenotypes related to Acquired Purpura Fulminans:

58 30 (show all 26)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 acrocyanosis 58 30 Frequent (33%) Frequent (79-30%)
HP:0001063
2 thrombocytopenia 58 30 Frequent (33%) Frequent (79-30%)
HP:0001873
3 skin rash 58 30 Frequent (33%) Frequent (79-30%)
HP:0000988
4 prolonged prothrombin time 58 30 Frequent (33%) Frequent (79-30%)
HP:0008151
5 decreased erythrocyte sedimentation rate 58 30 Frequent (33%) Frequent (79-30%)
HP:0025022
6 gangrene 58 30 Frequent (33%) Frequent (79-30%)
HP:0100758
7 abnormal blistering of the skin 58 30 Frequent (33%) Frequent (79-30%)
HP:0008066
8 disseminated intravascular coagulation 58 30 Frequent (33%) Frequent (79-30%)
HP:0005521
9 reduced protein c activity 58 30 Frequent (33%) Frequent (79-30%)
HP:0005543
10 erythematous macule 58 30 Frequent (33%) Frequent (79-30%)
HP:0025475
11 shock 58 30 Frequent (33%) Frequent (79-30%)
HP:0031273
12 prolonged partial thromboplastin time 58 30 Frequent (33%) Frequent (79-30%)
HP:0003645
13 immune dysregulation 58 30 Frequent (33%) Frequent (79-30%)
HP:0002958
14 hypofibrinogenemia 58 30 Frequent (33%) Frequent (79-30%)
HP:0011900
15 reduced protein s activity 58 30 Frequent (33%) Frequent (79-30%)
HP:0004855
16 macular purpura 58 30 Frequent (33%) Frequent (79-30%)
HP:0031365
17 elevated circulating c-reactive protein concentration 30 Frequent (33%) HP:0011227
18 neoplasm 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002664
19 sepsis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100806
20 intracranial hemorrhage 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002170
21 hepatic failure 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001399
22 pyoderma gangrenosum 58 30 Very rare (1%) Very rare (<4-1%)
HP:0025452
23 macule 58 Frequent (79-30%)
24 internal hemorrhage 58 Occasional (29-5%)
25 elevated c-reactive protein level 58 Frequent (79-30%)
26 abnormal thrombosis 58 Frequent (79-30%)

Drugs & Therapeutics for Acquired Purpura Fulminans

Search Clinical Trials, NIH Clinical Center for Acquired Purpura Fulminans

Genetic Tests for Acquired Purpura Fulminans

Anatomical Context for Acquired Purpura Fulminans

Organs/tissues related to Acquired Purpura Fulminans:

MalaCards : Skin

Publications for Acquired Purpura Fulminans

Articles related to Acquired Purpura Fulminans:

# Title Authors PMID Year
1
Severe acquired purpura fulminans in a child. 62
34417189 2022
2
Acquired purpura fulminans induced by alcohol and acetaminophen. Successful treatment with heparin and vitamin K. 62
8215490 1993
3
Rapid recovery of acquired purpura fulminans in a patient with familial C4bBP deficiency. 62
8486865 1993
4
Acquired purpura fulminans. 62
2281320 1990
5
Protein C and protein S levels in two patients with acquired purpura fulminans. 62
2142890 1990

Variations for Acquired Purpura Fulminans

Expression for Acquired Purpura Fulminans

Search GEO for disease gene expression data for Acquired Purpura Fulminans.

Pathways for Acquired Purpura Fulminans

GO Terms for Acquired Purpura Fulminans

Sources for Acquired Purpura Fulminans

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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