Acquired Purpura Fulminans disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

Orphanet: ⁵⁸ A life-threatening, rapidly progressive thrombotic disorder affecting mainly neonates and children that is characterized by purpuric skin lesions and disseminated intravascular coagulation. It may progress rapidly to multi-organ failure caused by thrombotic occlusion of small and medium-sized blood vessels. There are two forms of the disorder that are classified according to triggering mechanisms: acute infectious (the most common form), and idiopathic purpura fulminans.

MalaCards based summary: Acquired Purpura Fulminans is related to purpura fulminans and purpura. Affiliated tissues include skin, and related phenotypes are acrocyanosis and thrombocytopenia

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Related Diseases for Acquired Purpura Fulminans

Diseases in the Purpura Fulminans family:

Acquired Purpura Fulminans

Diseases related to Acquired Purpura Fulminans via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score
1	purpura fulminans	10.4
2	purpura	10.4
3	disseminated intravascular coagulation	10.2
4	alcohol dependence	10.0
5	exanthem	10.0
6	vitamin k deficiency bleeding	10.0
7	alcohol use disorder	10.0
8	viral exanthem	10.0
9	meningococcemia	10.0

Graphical network of the top 20 diseases related to Acquired Purpura Fulminans:

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Symptoms & Phenotypes for Acquired Purpura Fulminans

Human phenotypes related to Acquired Purpura Fulminans:

⁵⁸ ³⁰ (show all 26)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	acrocyanosis ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001063
2	thrombocytopenia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001873
3	skin rash ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000988
4	prolonged prothrombin time ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0008151
5	decreased erythrocyte sedimentation rate ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025022
6	gangrene ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0100758
7	abnormal blistering of the skin ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0008066
8	disseminated intravascular coagulation ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0005521
9	reduced protein c activity ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0005543
10	erythematous macule ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0025475
11	shock ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031273
12	prolonged partial thromboplastin time ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0003645
13	immune dysregulation ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002958
14	hypofibrinogenemia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0011900
15	reduced protein s activity ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0004855
16	macular purpura ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0031365
17	elevated circulating c-reactive protein concentration ³⁰	Frequent (33%)		HP:0011227
18	neoplasm ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002664
19	sepsis ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0100806
20	intracranial hemorrhage ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002170
21	hepatic failure ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001399
22	pyoderma gangrenosum ⁵⁸ ³⁰	Very rare (1%)	Very rare (<4-1%)	HP:0025452
23	macule ⁵⁸		Frequent (79-30%)
24	internal hemorrhage ⁵⁸		Occasional (29-5%)
25	elevated c-reactive protein level ⁵⁸		Frequent (79-30%)
26	abnormal thrombosis ⁵⁸		Frequent (79-30%)

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Drugs & Therapeutics for Acquired Purpura Fulminans

Search Clinical Trials, NIH Clinical Center for Acquired Purpura Fulminans

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Genetic Tests for Acquired Purpura Fulminans

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Anatomical Context for Acquired Purpura Fulminans

Organs/tissues related to Acquired Purpura Fulminans:

MalaCards : Skin

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Publications for Acquired Purpura Fulminans

Articles related to Acquired Purpura Fulminans:

#	Title	Authors	PMID	Year
1	Severe acquired purpura fulminans in a child. ⁶²	Liniger S...Kartal-Kaess M	34417189	2022
2	Acquired purpura fulminans induced by alcohol and acetaminophen. Successful treatment with heparin and vitamin K. ⁶²	Guccione JL...Neldner KH	8215490	1993
3	Rapid recovery of acquired purpura fulminans in a patient with familial C4bBP deficiency. ⁶²	Lemesle FG...Arich C	8486865	1993
4	Acquired purpura fulminans. ⁶²	Francis RB	2281320	1990
5	Protein C and protein S levels in two patients with acquired purpura fulminans. ⁶²	Madden RM...Marlar RA	2142890	1990

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Genes for Acquired Purpura Fulminans

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Variations for Acquired Purpura Fulminans

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Expression for Acquired Purpura Fulminans

Search GEO for disease gene expression data for Acquired Purpura Fulminans.

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Pathways for Acquired Purpura Fulminans

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GO Terms for Acquired Purpura Fulminans

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MCID: ACQ039 MIFTS: 18	Acquired Purpura Fulminans Categories: Blood diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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