Acquired Thrombocytopenia disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Acquired Thrombocytopenia

MalaCards integrated aliases for Acquired Thrombocytopenia:

Name: Acquired Thrombocytopenia ¹² ¹⁵ ⁷³

Secondary Thrombocytopenia ¹² ⁵⁵

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Immune diseases Blood diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism

Coagulation defects, purpura and other haemorrhagic conditions

Purpura and other haemorrhagic conditions

Secondary thrombocytopenia

External Ids:

Disease Ontology ¹² DOID:11126

ICD10 ³³ D69.5

ICD9CM ³⁵ 287.4

SNOMED-CT ⁶⁸ 154826009 191325008 267537007 more

UMLS ⁷³ C0154301

Sources

Summaries for Acquired Thrombocytopenia

MalaCards based summary : Acquired Thrombocytopenia, also known as secondary thrombocytopenia, is related to thrombocytopenia and thrombocytopenic purpura, autoimmune. An important gene associated with Acquired Thrombocytopenia is THPO (Thrombopoietin), and among its related pathways/superpathways are PAK Pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Bivalirudin and Heparin have been mentioned in the context of this disorder. Affiliated tissues include heart.

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Related Diseases for Acquired Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 2	Thrombocytopenia 3
Thrombocytopenia 1	Thrombocytopenia 4
Thrombocytopenia 5	Thrombocytopenia 6
Acquired Thrombocytopenia	Thrombocytopenia Due to Platelet Alloimmunization
Primary Thrombocytopenia	Myh9 Related Thrombocytopenia

Diseases related to Acquired Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)

#	Related Disease	Score	Top Affiliating Genes
1	thrombocytopenia	29.9	IL11 THPO
2	thrombocytopenic purpura, autoimmune	10.1	IL11 THPO
3	dengue disease	10.1	IL11 THPO
4	thrombocytosis	10.0	IL11 THPO
5	hemorrhagic disease	10.0	F11 THPO
6	megakaryocytic leukemia	10.0	IL11 THPO
7	bone marrow cancer	9.9	IL11 THPO
8	essential thrombocythemia	9.9	IL11 THPO
9	ischemia	9.8
10	hematologic cancer	9.7	IL11 THPO
11	myocardial infarction	9.6
12	acute myocardial infarction	9.6
13	heparin-induced thrombocytopenia	9.6
14	aplastic anemia	9.4	IL11 THPO
15	myelodysplastic syndrome	9.3	CTNNA1 IL11 THPO

Comorbidity relations with Acquired Thrombocytopenia via Phenotypic Disease Network (PDN): (show all 26)

Active Peptic Ulcer Disease	Acute Cystitis
Acute Kidney Failure	Alcoholic Liver Cirrhosis
Anemia, Autoimmune Hemolytic	Aortic Valve Disease 1
Chronic Kidney Failure	Decubitus Ulcer
Deficiency Anemia	Disseminated Intravascular Coagulation
Familial Atrial Fibrillation	Heart Disease
Hepatic Encephalopathy	Hypersplenism
Intermediate Coronary Syndrome	Ischemic Heart Disease
Leukemia, Chronic Lymphocytic	Megakaryocytic Leukemia
Mitral Valve Disease	Neutropenia
Oral Candidiasis	Portal Hypertension
Primary Thrombocytopenia	Protein-Energy Malnutrition
Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2	Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Thrombocytopenia:

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Symptoms & Phenotypes for Acquired Thrombocytopenia

Sources

Drugs & Therapeutics for Acquired Thrombocytopenia

Drugs for Acquired Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Bivalirudin

Approved, Investigational

Phase 3

128270-60-0

16129704

Synonyms:

(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-4-amino-2-[[2-[[2-[[2-[[2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2R)-2-amino-3-cyclohexylpropanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]acetyl]amino]-4-oxobutanoyl]amino]acetyl]amino]-4-hydroxy-4-oxobutanoyl]amino]-3-cyclohexylpropanoyl]amino]-5-hydroxy-5-oxopentanoyl]amino]-5-hydroxy-5-oxopentanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-hydroxy-5-oxopentanoyl]amino]-5-hydroxy-5-oxopentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-4-methylpentanoic acid

128270-60-0

Angiomax

BG 8967

BG8967

BG-8967

Bivalirudin

Bivalirudin [USAN:BAN:INN]

bivalirudina

Bivalirudina

bivalirudine

bivalirudinum

Bivalirudinum

C074619

C9H11NO.C2H6.CH4

CHEBI:59173

DB02351

D-Phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-L-leucine

Hirulog

Hirulog-1

HS-2004

LS-172701

Phe-Pro-Arg-Pro-(Gly)4 desulfato-Tyr63'-hirugen

Phe-Pro-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu

Phe-Pro-Arg-Pro-(Gly)4-desulfohirudin-(53-64)

The Medicines Company brand of bivalirudin

UNII-TN9BEX005G

2

Heparin

Approved, Investigational

Phase 3

9005-49-6

772 46507594

Synonyms:

101921-26-0

102785-31-9

102-94-3

104521-37-1

11078-24-3

11129-39-8

12656-11-0

37324-73-5

9041-08-1

9045-22-1

9075-96-1

913079-23-9

91449-79-5

AC1L1ROY

ALFA 87-120

ALFA 87-163

ALFA 87-198

ALFA 87-81

ALFA 88-247

Allocinnamic acid

alpha-Heparin

Alpha-Heparin

Ardeparin

Ardeparin sodium

Ariven

Arteven

Bemiparin

Bemiparin sodium

Calcilean

Calciparine

Certoparin

CID8784

cis-.beta.-Carboxystyrene

cis-Cinnamic acid

Clexane

Clivarin

Clivarine

CY 216

Cy 222

Dalteparin

Dalteparin sodium

Depo-Heparin

EINECS 232-681-7

Enoxaparin

Enoxaparin sodium

Eparina

Eparina [DCIT]

Fluxum

FR 860

Fragmin A

Fragmin B

Fragmin IV

Fraxiparin

H 2149

Hed-heparin

Hed-Heparin

Hep Flush Kit in plastic container

Hepalean

heparin

Heparin Cy 216

Heparin CY 216

Heparin Leo

Heparin Lock Flush

Heparin Lock Flush in plastic container

Heparin Lock Flush preservative free

Heparin Lock Flush preservative free in plastic container

Heparin natrium

Heparin sodium

Heparin sodium 1,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 1,000 units in dextrose 5% in plastic container

Heparin sodium 1,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 10,000 units in dextrose 5%

Heparin sodium 10,000 units in dextrose 5% in plastic container

Heparin sodium 10,000 units in sodium chloride 0.45%

Heparin sodium 10,000 units in sodium chloride 0.9%

Heparin sodium 12,500 units in dextrose 5%

Heparin sodium 12,500 units in dextrose 5% in plastic container

Heparin sodium 12,500 units in sodium chloride 0.45% in plastic container

Heparin sodium 12,500 units in sodium chloride 0.9%

Heparin sodium 2,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 2,000 units in dextrose 5% in plastic container

Heparin sodium 2,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 20,000 units and dextrose 5% in plastic container

Heparin sodium 20,000 units in dextrose 5% in plastic container

Heparin sodium 25,000 units and dextrose 5% in plastic container

Heparin sodium 25,000 units in dextrose 5%

Heparin sodium 25,000 units in dextrose 5% in plastic container

Heparin sodium 25,000 units in sodium chloride 0.45% in plastic container

Heparin sodium 25,000 units in sodium chloride 0.9%

Heparin sodium 25,000 units in sodium chloride 0.9% in plastic container

Heparin sodium 5,000 units and sodium chloride 0.9% in plastic container

Heparin sodium 5,000 units in dextrose 5% in plastic container

Heparin sodium 5,000 units in sodium chloride 0.45%

Heparin sodium 5,000 units in sodium chloride 0.9%

Heparin sodium 5,000 units in sodium chloride 0.9% in plastic container

Heparin sodium in plastic container

Heparin sodium preservative Free

Heparin sodium salt

Heparin sulfate

Heparin sulphate

Heparin, sodium salt

Heparina

Heparina [INN-Spanish]

Heparinate

Heparine

Heparine [INN-French]

Heparinic acid

Heparinsodiumsalt

Heparinum

Heparinum [INN-Latin]

Heparinum natricum

Hepathrom

Hepflush-10

Hep-Lock

Hep-Lock U/P

HSDB 3094

Innohep

Inno-Hep

Isocinnamic acid

Kabi 2165

KB 101

Leparan

LHN 1

Lioton 1000

Lipo-hepin

Lipo-Hepin

Liquaemin

Liquaemin Lock Flush

Liquaemin Sodium

Liquaemin sodium preservative free

Liquemin

Logiparin

Low molecular weight heparin sodium

Minolteparin sodium

MolPort-003-760-257

Multiparin

Nadroparin

Nadroparine

Novoheparin

NSC174025

Octaparin

OP 386

OP 622

Pabyrin

Panheprin

Parnaparin

Parnaparin sodium

Parvoparin

Pularin

Reviparin

Reviparin sodium

Ro 11

Sandoparin

Sodium acid heparin

Sodium heparin

Sodium heparinate

Subeparin

Sublingula

Thromboliquine

Tinzaparin

Tinzaparin sodium

Triofiban

Unfractionated heparin

UNII-12M44VTJ7B

UNII-3S182ET3UA

UNII-E47C0NF7LV

UNII-T2410KM04A

UNII-ZZ45AB24CA

Vetren

Vitrum AB

WY 90493RD

3

Thrombin

Approved, Investigational

Phase 3

4

Serine

Approved, Nutraceutical

Phase 3

56-45-1

5951

Synonyms:

(-)-Serine

(2S)-2-amino-3-Hydroxypropanoate

(2S)-2-amino-3-Hydroxypropanoic acid

(S)-(-)-Serine

(S)-2-amino-3-Hydroxypropanoate

(S)-2-amino-3-Hydroxy-propanoate

(S)-2-amino-3-Hydroxypropanoic acid

(S)-2-amino-3-Hydroxy-propanoic acid

(S)-2-Amino-3-hydroxypropanoic acid

(S)-a-amino-b-Hydroxypropionate

(S)-a-amino-b-Hydroxypropionic acid

(S)-alpha-amino-beta-Hydroxypropionate

(S)-alpha-amino-beta-Hydroxypropionic acid

(S)-b-amino-3-Hydroxypropionate

(S)-b-amino-3-Hydroxypropionic acid

(S)-beta-amino-3-Hydroxypropionate

(S)-beta-amino-3-Hydroxypropionic acid

(S)-Serine

(S)-α-amino-β-hydroxypropionate

(S)-α-amino-β-hydroxypropionic acid

2-amino-3-Hydroxypropanoate

2-amino-3-Hydroxypropanoic acid

3-Hydroxy-L-alanine

alpha-Amino-beta-hydroxypropionic acid

beta-Hydroxyalanine

beta-Hydroxy-L-alanine

b-Hydroxyalanine

b-Hydroxy-L-alanine

L Serine

L-(-)-Serine

L-2-amino-3-Hydroxypropionate

L-2-amino-3-Hydroxypropionic acid

L-3-Hydroxy-2-aminopropionate

L-3-Hydroxy-2-aminopropionic acid

L-3-Hydroxy-alanine

L-Ser

L-Serin

L-Serine

S

Ser

Serina

SERINE

Serinum

β-hydroxyalanine

β-hydroxy-L-alanine

5

Anticoagulants

Phase 3

6

Antithrombin III

Phase 3

7

Antithrombins

Phase 3

8

calcium heparin

Phase 3

9

Calcium, Dietary

Phase 3

10

Fibrinolytic Agents

Phase 3

11

Hirudins

Phase 3

12

HIV Protease Inhibitors

Phase 3

13

protease inhibitors

Phase 3

14

Serine Proteinase Inhibitors

Phase 3

15

Cytarabine

Approved, Investigational

Phase 2

147-94-4

6253

Synonyms:

(beta-D-Arabinofuranosyl)cytosine

1-.beta.-D-arabinofuranosyl-cytosine

147-94-4

1-Arabinofuranosylcytosine

1-b-D-Arabinofuranosylcytosine

1beta -Arabinofuranasylcytosine

1-beta -D-Arabinofaranosylcytosine

1-beta -D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone

1beta -D-Arabinofuranosylcytosine

1-beta -D-Arabinofuranosylcytosine

1beta -D-Arabinosylcytosine

1beta-Arabinofuranasylcytosine

1-beta-D-Arabinofaranosylcytosine

1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone

1beta-D-Arabinofuranosylcytosine

1-beta-D-Arabinofuranosylcytosine

1-beta-D-Arabinofuranosyl-cytosine

1-beta-D-Arabinofuranosylcytosine, cytosine arabinoside

1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside

1beta-D-Arabinosylcytosine

1-beta-D-Arabinosylcytosine

1-beta-D-Arabinosyl-cytosine

1-β-D-arabinofuranosylcytosine

2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl- [CAS]

2(1H)-Pyrimidinone, 4-amino-1- -D-arabinofuranosyl

30399_FLUKA

4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one

4-amino-1-Arabinofuranosyl-2-oxo-1,2-dihydropyrimidin

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]

4-amino-1-Arabinofuranosyl-2-oxo-1,2-dihydropyrimidine

4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine

4-amino-1-b-D-Arabinofuranosyl-2(1H)-pyrimidinone

4-amino-1-b-D-Arabinofuranosyl-2-(1H)-pyrimidinone

4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]

4-amino-1-beta-D-Arabinofuranosyl-2(1H)-pyrimidinone

4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone

4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one

4-amino-1-beta-D-Arabinofuranosylpyrimidin-2(1H)-one

4-amino-1-β-D-arabinofuranosyl-2(1H)-pyrimidinone

69-74-9 (hydrochloride)

AC-1075

AC1L1M4F

AC1Q52OJ

AI3-52329

Alexan

AR3

Arabinocytidine

Arabinofuranosylcytosine

Arabinoside, cytosine

Arabinosyl Cytosine

Arabinosylcytosine

Arabitin

AraC

Ara-C

Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine

Aracytidine

Ara-Cytidine

Aracytin

Aracytine

Arafcyt

beta -Arabinosylcytosine

beta -Cytosine arabinoside

beta -D-Arabinosylcytosine

beta-Ara c

beta-Ara C

beta-Arabinosylcytosine

beta-Cytosine arabinoside

Beta-cytosine arabinoside

beta-D-Arabinosylcytosine

BIDD:GT0371

BIDD:PXR0139

BTB15125

C02961

C1768_SIGMA

C2035

C9H13N3O5

CCRIS 913

CHEBI:28680

CHEMBL803

CHX 3311

CID6253

Citarabina

Citarabina [INN-Spanish]

CPD000449317

Cytarabin

Cytarabina

cytarabine

Cytarabine (JP15/USP/INN)

CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9)

Cytarabine [USAN:INN:BAN:JAN]

Cytarabine hydrochloride

cytarabine liposome injection

Cytarabine liposome injection

Cytarabinoside

Cytarabinum

Cytarabinum [INN-Latin]

Cytarbel

Cytonal

Cytosar

Cytosar u

Cytosar-u

CytosarU

Cytosar-U

Cytosine 1-beta-D-arabinofuranoside

Cytosine arabinofuranoside

Cytosine arabinose

Cytosine arabinoside

Cytosine arabinoside (VAN)

Cytosine beta-D-arabinofuranoside

Cytosine beta-D-arabinofuranoside hydrochloride

Cytosine beta-D-arabinoside

Cytosine, beta -D-arabinoside

Cytosine, beta-D-arabinoside

Cytosine-1-b-D-arabinofuranoside

Cytosine-1-beta-D-arabinofuranoside

Cytosine-1-beta-D-arabinofuranoside hydrochloride

Cytosine-1-β-D-arabinofuranoside

Cytosinearabinoside

Cytosine-b-D-arabinofuranoside

Cytosine-beta -arabinoside

Cytosine-beta -D-arabinofuranoside

Cytosine-beta-arabinoside

Cytosine-beta-D-arabinofuranoside

cytosine-β-D-arabinofuranoside

Cytosine-β-D-arabinofuranoside

D00168

DB00987

Depocyt

Depocyt (liposomal)

Depocyt (TN)

Depocyte

DepoCyte

EINECS 205-705-9

Erpalfa

FT-0082880

HMS2051K19

HMS2090A18

HSDB 3049

Hydrochloride, cytarabine

Intrathecal (injected into the spinal fluid) DepoCyt

Intrathecal cytarabine (also known as ara-C)

Iretin

Lopac0_000316

LS-860

MLS000758310

MLS001066340

MolPort-001-792-509

NCGC00093356-03

NCGC00093356-04

NCGC00093356-05

NCI-C04728

NSC 287459

NSC287459

S1648_Selleck

SAM001247012

SMR000449317

Spongocytidine

SR-01000075773-3

Tarabine

TL8001048

U 19920A

U-19,920

U-19920

Udicil

UNII-04079A1RDZ

ZINC03795098

16

Daunorubicin

Approved

Phase 2

20830-81-3

30323

Synonyms:

(+)-Daunomycin

(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-(methyloxy)-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside

(1S,3S)-3-acetyl-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracen-1-yl 3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranoside

(7S,9R)-9-Acetyl-7-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-oxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

(7S,9S)-9-acetyl-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione

(8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione

(8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione

(8S-cis)-8-Acetyl-10-((3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyrannosyl)oxy)-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-napthacenedione

(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro--6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione

11006-54-5

11048-29-6

1407-15-4

149541-57-1

20830-81-3

23942-76-9

27576-81-4

28020-80-6

AB00514669

AC1L1JCP

AC1Q29OI

Acetyladriamycin

AI3-52942

Anthracyline

Antibiotics from Streptomyces coeruleorubidus

Antibiotics From Streptomyces Coeruleorubidus

BPBio1_000389

BRD-K43389675-003-02-7

BRN 1445583

BSPBio_000353

C01907

CCRIS 914

Cerubidin

Cerubidine

CHEBI:41977

CHEMBL178

CID30323

D07776

Daunamycin

Daunarubicinum

dauno Rubidomycine

Daunoblastin

Daunoblastine

Daunomycin

Daunomycin Hydrochloride

Daunomycin, Hydrochloride

Daunorrubicina

daunorubicin

Daunorubicin

Daunorubicin (INN)

Daunorubicin (liposomal)

Daunorubicin [INN:BAN]

Daunorubicin Hcl

DAUNORUBICIN HCL

Daunorubicin hydrochloride

Daunorubicin Hydrochloride

Daunorubicin, Hydrochloride

Daunorubicina

Daunorubicine

Daunorubicinum

Daunorubicinum [INN-Latin]

dauno-Rubidomycine

Dauno-Rubidomycine

Daunoxome

DaunoXome

DaunoXome (TN)

DB00694

DM1

EINECS 244-069-7

FI 6339

FI6339

HMS2089H04

HMS2091K06

HSDB 5095

Hydrochloride, daunorubicin

Leukaemomycin C

LMPK13050002

LS-187381

LS-997

MolPort-002-533-961

NCGC00024246-05

NCGC00024246-06

NCGC00025173-01

NChemBio.2007.10-comp14

nchembio723-comp2

NCI-C04693

NSC 83142

NSC-82151

Ondena

Prestwick3_000487

Rcra Waste No. U059

RCRA waste no. U059

RP 13057

Rp 13057 Hydrochloride

Rubidomycin

Rubidomycin Hydrochloride

Rubomycin

Rubomycin C

Tocris-1467

UNII-ZS7284E0ZP

VS-103

17

Anti-Bacterial Agents

Phase 2

18

Antibiotics, Antitubercular

Phase 2

19

Anti-Infective Agents

Phase 2

20

Antimetabolites

Phase 2

21

Antimetabolites, Antineoplastic

Phase 2

22

Antiviral Agents

Phase 2

23

Immunosuppressive Agents

Phase 2

24

Topoisomerase Inhibitors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH	Completed	NCT01651780	Phase 3	Bivalirudin;Unfractionated Heparin
2	Efficacy of Eltrombopag to Improve Thrombocytopenia of MYH9-related Disease	Completed	NCT01133860	Phase 2	eltrombopag
3	A Safety and Efficacy Study of Eltrombopag in Subjects With AML	Completed	NCT01890746	Phase 2	Daunorubicin;Cytarabine;Eltrombopag;Placebo
4	Busulfan, Fludarabine, and Thiotepa Conditioning Regimen for Non Malignant Disease	Recruiting	NCT03513328	Phase 1, Phase 2	Thiotepa--single daily dose;Thiotepa--escalated dose
5	WEUSKOP5410: Observational Study in ENABLE Clinical Trials	Completed	NCT01458080		eltrombopag
6	Differential Diagnostic of Immune ThrombocytoPenia (ITP) and Myelodysplastic Syndrome (MDS)	Recruiting	NCT03469661

Search NIH Clinical Center for Acquired Thrombocytopenia

Sources

Genetic Tests for Acquired Thrombocytopenia

Sources

Anatomical Context for Acquired Thrombocytopenia

MalaCards organs/tissues related to Acquired Thrombocytopenia:

⁴¹

Heart

Sources

Publications for Acquired Thrombocytopenia

Articles related to Acquired Thrombocytopenia:

(show all 15)

#	Title	Authors	Year
1	Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). ( 29632238 )	Groves E.M....Price M.J.	2018
2	The impact of acquired thrombocytopenia on long-term outcomes of patients undergoing elective percutaneous coronary intervention: An analysis of 8,271 consecutive patients. ( 29368387 )	Liu S....Xu B.	2018
3	Recent advances in understanding and management of acquired thrombocytopenia. ( 29399327 )	Nagalla S....Sarode R.	2018
4	The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis. ( 27689317 )	Oikonomou E.K....Kampaktsis P.N.	2016
5	Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement. ( 25204308 )	Flaherty M.P....Hirsch G.A.	2014
6	Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes. ( 24598983 )	Dvir D....Waksman R.	2014
7	Hospital-acquired thrombocytopenia. ( 25502138 )	McMahon C.M....Cuker A.	2014
8	Long-term outcomes associated with hospital acquired thrombocytopenia among patients with non-ST-segment elevation acute coronary syndrome. ( 25066558 )	Vora A.N....Wang T.Y.	2014
9	Occurrence and clinical significance of in-hospital acquired thrombocytopenia in patients undergoing transcatheter device closure for congenital heart defect. ( 23026381 )	Li P....Qin Y.	2012
10	Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. ( 21315212 )	Caixeta A....Stone G.W.	2011
11	Impact of in-hospital acquired thrombocytopenia in patients undergoing primary angioplasty for acute myocardial infarction. ( 16098296 )	Nikolsky E....Stone G.W.	2005
12	Congenital and acquired thrombocytopenia. ( 15561694 )	Cines D.B....Zehnder J.L.	2004
13	Further complexities in diagnosing acquired thrombocytopenia: unexpected parallels between antibody-mediated delayed thrombocytopenia with abciximab and heparin induced thrombocytopenia. ( 15467893 )	Hayward C.P.	2004
14	Platelet size and kinetics in hereditary and acquired thrombocytopenia. ( 5062078 )	Murphy S....GARDNER F.H.	1972
15	Acquired thrombocytopenia following transfusion with bank blood; report of a case. ( 13330381 )	KAETZ H.W....Malone R.	1956

Sources

Genes for Acquired Thrombocytopenia

Genes related to Acquired Thrombocytopenia (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	THPO	Thrombopoietin	Protein Coding	22.39	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : DISEASES inferred (show sections)	10194430 11972101 8896400 (more) 10997880 18928635
2	IL11	Interleukin 11	Protein Coding	16.17	Novoseek inferred ⁵⁵ GeneCards inferred via : Novoseek inferred (show sections)	11972106 8896400
3	CTNNA1	Catenin Alpha 1	Protein Coding	15.4	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	SLC35G5	Solute Carrier Family 35 Member G5	Protein Coding	14.97	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	F11	Coagulation Factor XI	Protein Coding	14.93	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for Acquired Thrombocytopenia

Sources

Expression for Acquired Thrombocytopenia

Search GEO for disease gene expression data for Acquired Thrombocytopenia.

Sources

Pathways for Acquired Thrombocytopenia

Pathways related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	12.5	CTNNA1 IL11 THPO
2	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.28	IL11 THPO
3	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	11.02	IL11 THPO
4	Hematopoietic cell lineage ³⁷	10.61	IL11 THPO

Sources

GO Terms for Acquired Thrombocytopenia

Molecular functions related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	cytokine activity	GO:0005125	8.96	IL11 THPO
2	growth factor activity	GO:0008083	8.62	IL11 THPO

Sources

Sources for Acquired Thrombocytopenia

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia