MCID: ACQ005
MIFTS: 41

Acquired Thrombocytopenia

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acquired Thrombocytopenia

MalaCards integrated aliases for Acquired Thrombocytopenia:

Name: Acquired Thrombocytopenia 12 15 74
Secondary Thrombocytopenia 12 56

Classifications:



External Ids:

Disease Ontology 12 DOID:11126
ICD9CM 36 287.4
SNOMED-CT 69 74576004
ICD10 34 D69.5
UMLS 74 C0154301

Summaries for Acquired Thrombocytopenia

MalaCards based summary : Acquired Thrombocytopenia, also known as secondary thrombocytopenia, is related to thrombocytopenia and fetal and neonatal alloimmune thrombocytopenia. An important gene associated with Acquired Thrombocytopenia is THPO (Thrombopoietin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Thrombin and Bivalirudin have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and heart, and related phenotypes are no effect and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Acquired Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 2 Thrombocytopenia 3
Thrombocytopenia 1 Thrombocytopenia 4
Thrombocytopenia 5 Thrombocytopenia 6
Acquired Thrombocytopenia Thrombocytopenia Due to Platelet Alloimmunization
Primary Thrombocytopenia Ankrd26-Related Thrombocytopenia
Myh9 Related Thrombocytopenia

Diseases related to Acquired Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 30.8 GP1BB IL11 ITGA2B THPO
2 fetal and neonatal alloimmune thrombocytopenia 10.4 GP1BB ITGA2B
3 acquired hemophilia 10.4 F11 F8
4 acquired hemophilia a 10.4 F11 F8
5 acquired von willebrand syndrome 10.4 F11 F8
6 hobnail hemangioma 10.4 F8 WT1
7 fournier gangrene 10.3 F8 SERPINC1
8 thrombocytopenic purpura, autoimmune 10.3 IL11 ITGA2B THPO
9 megakaryocytic leukemia 10.3 IL11 ITGA2B THPO
10 aspirin allergy 10.3 ITGA2B SERPINC1
11 subacute lymphocytic thyroiditis 10.3 TG TPO
12 familial thyroid dyshormonogenesis 10.3 TG TPO
13 thrombocytosis 10.3 IL11 SERPINC1 THPO
14 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TG TPO
15 autosomal dominant macrothrombocytopenia 10.3 GP1BB ITGA2B
16 fungal esophagitis 10.3 ATP12A ATP4A
17 diclofenac allergy 10.3 ATP12A ATP4A
18 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
19 neonatal candidiasis 10.3 ATP12A ATP4A
20 photoallergic dermatitis 10.2 ATP12A ATP4A
21 toxic megacolon 10.2 ATP12A ATP4A
22 aspiration pneumonitis 10.2 ATP12A ATP4A
23 gastrointestinal neuroendocrine benign tumor 10.2 ATP12A ATP4A
24 hemophilia b 10.2 F11 F8 SERPINC1
25 alcohol-related birth defect 10.2 F11 F8
26 gastric antral vascular ectasia 10.2 ATP12A ATP4A
27 granulomatous gastritis 10.2 ATP12A ATP4A
28 esophageal candidiasis 10.2 ATP12A ATP4A
29 gastric neuroendocrine neoplasm 10.2 ATP12A ATP4A
30 acute laryngitis 10.2 ATP12A ATP4A
31 laryngitis 10.2 ATP12A ATP4A
32 duodenitis 10.2 ATP12A ATP4A
33 rumination disorder 10.2 ATP12A ATP4A
34 active peptic ulcer disease 10.2 ATP12A ATP4A
35 intracranial thrombosis 10.2 F8 ITGA2B SERPINC1
36 thrombophilia 10.2 F11 F8 SERPINC1
37 congenital disorder of deglycosylation 10.2 ATP12A ATP4A
38 bernard-soulier syndrome 10.2 F8 GP1BB ITGA2B THPO
39 bladder calculus 10.2 ATP12A ATP4A
40 ischemic neuropathy 10.2 ATP12A ATP4A
41 bile reflux 10.2 ATP12A ATP4A
42 hematologic cancer 10.2 CBL IL11 THPO WT1
43 endemic goiter 10.2 TG TPO
44 capillary disease 10.2 ATP12A ATP4A
45 peptic esophagitis 10.2 ATP12A ATP4A
46 dyskinesia of esophagus 10.1 ATP12A ATP4A
47 purpura 10.1 GP1BB ITGA2B SERPINC1 THPO
48 hernia, hiatus 10.1 ATP12A ATP4A
49 anismus 10.1 ATP12A ATP4A
50 inherited blood coagulation disease 10.1 F8 GP1BB ITGA2B SERPINC1

Comorbidity relations with Acquired Thrombocytopenia via Phenotypic Disease Network (PDN): (show all 26)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alcoholic Liver Cirrhosis
Anemia, Autoimmune Hemolytic Aortic Valve Disease 1
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Disseminated Intravascular Coagulation
Familial Atrial Fibrillation Heart Disease
Hepatic Encephalopathy Hypersplenism
Intermediate Coronary Syndrome Ischemic Heart Disease
Leukemia, Chronic Lymphocytic Megakaryocytic Leukemia
Mitral Valve Disease Neutropenia
Oral Candidiasis Portal Hypertension
Primary Thrombocytopenia Protein-Energy Malnutrition
Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2 Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Thrombocytopenia:



Diseases related to Acquired Thrombocytopenia

Symptoms & Phenotypes for Acquired Thrombocytopenia

GenomeRNAi Phenotypes related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 9.92 ATP12A ATP4A ATP5PO CBL CD1A CTPS1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.7 IFNA1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.7 IFNA1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-144 9.7 THPO
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-145 9.7 IFNA1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.7 TPO
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-175 9.7 IFNA1 THPO TPO
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.7 IFNA1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.7 IFNA1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.7 IFNA1

MGI Mouse Phenotypes related to Acquired Thrombocytopenia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.9 ATP4A CBL F11 F8 GP1BB ITGA2B
2 homeostasis/metabolism MP:0005376 9.77 ATP12A ATP4A CBL F11 F8 GP1BB
3 immune system MP:0005387 9.32 ATP4A CBL F11 F8 ITGA2B SERPINC1

Drugs & Therapeutics for Acquired Thrombocytopenia

Drugs for Acquired Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Thrombin Approved, Investigational Phase 3
2
Bivalirudin Approved, Investigational Phase 3 128270-60-0 16129704
3
Heparin Approved, Investigational Phase 3 9005-49-6 46507594 772
4
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
5
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
6 Calcium, Dietary Phase 3
7 HIV Protease Inhibitors Phase 3
8 Anticoagulants Phase 3
9 Hirudins Phase 3
10
protease inhibitors Phase 3
11 Fibrinolytic Agents Phase 3
12 Antithrombin III Phase 3
13 calcium heparin Phase 3
14 Serine Proteinase Inhibitors Phase 3
15 Antithrombins Phase 3
16
Daunorubicin Approved Phase 2 20830-81-3 30323
17
Cytarabine Approved, Experimental, Investigational Phase 2 147-94-4, 65-46-3 6253
18
Thiotepa Approved, Investigational Phase 1, Phase 2 52-24-4 5453
19
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
20
Fludarabine Approved Phase 1, Phase 2,Phase 2 75607-67-9, 21679-14-1 30751
21 Topoisomerase Inhibitors Phase 2
22 Immunologic Factors Phase 2,Phase 1
23 Antiviral Agents Phase 2
24 Anti-Infective Agents Phase 2
25 Immunosuppressive Agents Phase 2,Phase 1
26 Antibiotics, Antitubercular Phase 2
27 Antimetabolites, Antineoplastic Phase 2,Phase 1
28 Anti-Bacterial Agents Phase 2
29 Antimetabolites Phase 2,Phase 1
30 Alkylating Agents Phase 1, Phase 2
31 Antilymphocyte Serum Phase 1, Phase 2
32 Thymoglobulin Phase 1, Phase 2
33 Antineoplastic Agents, Alkylating Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH Completed NCT01651780 Phase 3 Bivalirudin;Unfractionated Heparin
2 Efficacy of Eltrombopag to Improve Thrombocytopenia of MYH9-related Disease Completed NCT01133860 Phase 2 eltrombopag
3 A Safety and Efficacy Study of Eltrombopag in Subjects With AML Completed NCT01890746 Phase 2 Daunorubicin;Cytarabine;Eltrombopag;Placebo
4 Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation Recruiting NCT03513328 Phase 1, Phase 2 Thiotepa--single daily dose;Thiotepa--escalated dose
5 WEUSKOP5410: Observational Study in ENABLE Clinical Trials Completed NCT01458080 eltrombopag
6 Differential Diagnostic of Immune ThrombocytoPenia (ITP) and Myelodysplastic Syndrome (MDS) Recruiting NCT03469661

Search NIH Clinical Center for Acquired Thrombocytopenia

Genetic Tests for Acquired Thrombocytopenia

Anatomical Context for Acquired Thrombocytopenia

MalaCards organs/tissues related to Acquired Thrombocytopenia:

42
Thyroid, Bone, Heart, Bone Marrow, Myeloid

Publications for Acquired Thrombocytopenia

Articles related to Acquired Thrombocytopenia:

(show all 23)
# Title Authors Year
1
Eltrombopag for Delayed Platelet Recovery and Secondary Thrombocytopenia Following Allogeneic Stem Cell Transplantation in Children. ( 30080752 )
2019
2
Correction to: Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). ( 30354600 )
2018
3
Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). ( 29632238 )
2018
4
Recent advances in understanding and management of acquired thrombocytopenia. ( 29399327 )
2018
5
The impact of acquired thrombocytopenia on long-term outcomes of patients undergoing elective percutaneous coronary intervention: An analysis of 8,271 consecutive patients. ( 29368387 )
2018
6
The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis. ( 27689317 )
2016
7
Romiplostim for secondary thrombocytopenia following allogeneic stem cell transplantation in children. ( 26084627 )
2015
8
Non-surgical contraindication for acute appendicitis with secondary thrombocytopenia: a case report. ( 25759558 )
2015
9
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement. ( 25204308 )
2015
10
Hospital-acquired thrombocytopenia. ( 25502138 )
2014
11
Long-term outcomes associated with hospital acquired thrombocytopenia among patients with non-ST-segment elevation acute coronary syndrome. ( 25066558 )
2014
12
Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes. ( 24598983 )
2014
13
Romiplostim for delayed platelet recovery and secondary thrombocytopenia following allogeneic stem cell transplantation. ( 23997988 )
2013
14
Occurrence and clinical significance of in-hospital acquired thrombocytopenia in patients undergoing transcatheter device closure for congenital heart defect. ( 23026381 )
2012
15
Epidemiology of primary and secondary thrombocytopenia: first analysis of an administrative database in a major Italian institution. ( 22343688 )
2012
16
Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. ( 21315212 )
2011
17
Impact of in-hospital acquired thrombocytopenia in patients undergoing primary angioplasty for acute myocardial infarction. ( 16098296 )
2005
18
Congenital and acquired thrombocytopenia. ( 15561694 )
2004
19
Further complexities in diagnosing acquired thrombocytopenia: unexpected parallels between antibody-mediated delayed thrombocytopenia with abciximab and heparin induced thrombocytopenia. ( 15467893 )
2004
20
Secondary thrombocytopenia following phenobarbital treatments in a rhesus monkey (Macaca mulatta). ( 108473 )
1979
21
Platelet size and kinetics in hereditary and acquired thrombocytopenia. ( 5062078 )
1972
22
Transfusions of fresh platelet concentrates to patients with secondary thrombocytopenia. ( 14028146 )
1963
23
Acquired thrombocytopenia following transfusion with bank blood; report of a case. ( 13330381 )
1956

Variations for Acquired Thrombocytopenia

Expression for Acquired Thrombocytopenia

Search GEO for disease gene expression data for Acquired Thrombocytopenia.

Pathways for Acquired Thrombocytopenia

GO Terms for Acquired Thrombocytopenia

Cellular components related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.23 ATP4A F11 F8 IFNA1 IL11 SERPINC1

Biological processes related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood coagulation GO:0007596 9.55 F11 F8 GP1BB IFNA1 SERPINC1
2 cellular sodium ion homeostasis GO:0006883 9.46 ATP12A ATP4A
3 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.43 ATP12A ATP4A
4 cellular potassium ion homeostasis GO:0030007 9.4 ATP12A ATP4A
5 regulation of blood coagulation GO:0030193 9.37 F11 SERPINC1
6 sodium ion export across plasma membrane GO:0036376 9.32 ATP12A ATP4A
7 hormone biosynthetic process GO:0042446 9.26 TG TPO
8 blood coagulation, intrinsic pathway GO:0007597 9.13 F11 F8 GP1BB
9 hemostasis GO:0007599 8.92 F11 F8 GP1BB SERPINC1

Molecular functions related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 8.96 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.62 ATP12A ATP4A

Sources for Acquired Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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