MCID: ACQ005
MIFTS: 31

Acquired Thrombocytopenia

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Acquired Thrombocytopenia

MalaCards integrated aliases for Acquired Thrombocytopenia:

Name: Acquired Thrombocytopenia 12 15 73
Secondary Thrombocytopenia 12 55

Classifications:



External Ids:

Disease Ontology 12 DOID:11126
ICD10 33 D69.5
ICD9CM 35 287.4
SNOMED-CT 68 74576004
UMLS 73 C0154301

Summaries for Acquired Thrombocytopenia

MalaCards based summary : Acquired Thrombocytopenia, also known as secondary thrombocytopenia, is related to thrombocytopenia and dengue disease. An important gene associated with Acquired Thrombocytopenia is THPO (Thrombopoietin), and among its related pathways/superpathways are PAK Pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Bivalirudin and Thrombin have been mentioned in the context of this disorder. Affiliated tissues include bone, heart and bone marrow.

Related Diseases for Acquired Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 2 Thrombocytopenia 3
Thrombocytopenia 1 Thrombocytopenia 4
Thrombocytopenia 5 Thrombocytopenia 6
Acquired Thrombocytopenia Thrombocytopenia Due to Platelet Alloimmunization
Primary Thrombocytopenia Ankrd26-Related Thrombocytopenia
Myh9 Related Thrombocytopenia

Diseases related to Acquired Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 thrombocytopenia 30.5 THPO IL11
2 dengue disease 10.0 THPO IL11
3 thrombocytopenic purpura, autoimmune 10.0 THPO IL11
4 thrombocytosis 10.0 THPO IL11
5 megakaryocytic leukemia 10.0 THPO IL11
6 hemorrhagic disease 10.0 THPO F11
7 deficiency anemia 10.0 THPO IL11
8 bone marrow cancer 10.0 THPO IL11
9 essential thrombocythemia 9.9 THPO IL11
10 hematologic cancer 9.9 THPO IL11
11 aplastic anemia 9.8 THPO IL11
12 myelodysplastic syndrome 9.8 THPO IL11 CTNNA1
13 myocardial infarction 9.7
14 acute myocardial infarction 9.7
15 ischemia 9.7
16 heparin-induced thrombocytopenia 9.7
17 appendicitis 9.6

Comorbidity relations with Acquired Thrombocytopenia via Phenotypic Disease Network (PDN): (show all 26)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alcoholic Liver Cirrhosis
Anemia, Autoimmune Hemolytic Aortic Valve Disease 1
Chronic Kidney Failure Decubitus Ulcer
Deficiency Anemia Disseminated Intravascular Coagulation
Familial Atrial Fibrillation Heart Disease
Hepatic Encephalopathy Hypersplenism
Intermediate Coronary Syndrome Ischemic Heart Disease
Leukemia, Chronic Lymphocytic Megakaryocytic Leukemia
Mitral Valve Disease Neutropenia
Oral Candidiasis Portal Hypertension
Primary Thrombocytopenia Protein-Energy Malnutrition
Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2 Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Thrombocytopenia:



Diseases related to Acquired Thrombocytopenia

Symptoms & Phenotypes for Acquired Thrombocytopenia

Drugs & Therapeutics for Acquired Thrombocytopenia

Drugs for Acquired Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bivalirudin Approved, Investigational Phase 3 128270-60-0 16129704
2
Thrombin Approved, Investigational Phase 3
3
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
4
Serine Approved, Nutraceutical Phase 3 56-45-1 5951
5 Serine Proteinase Inhibitors Phase 3
6
protease inhibitors Phase 3
7 calcium heparin Phase 3
8 Calcium, Dietary Phase 3
9 HIV Protease Inhibitors Phase 3
10 Hirudins Phase 3
11 Antithrombins Phase 3
12 Antithrombin III Phase 3
13 Fibrinolytic Agents Phase 3
14 Anticoagulants Phase 3
15
Cytarabine Approved, Investigational Phase 2 147-94-4 6253
16
Daunorubicin Approved Phase 2 20830-81-3 30323
17
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
18
Fludarabine Approved Phase 1, Phase 2,Phase 2 75607-67-9, 21679-14-1 30751
19
Thiotepa Approved, Investigational Phase 1, Phase 2 52-24-4 5453
20 Immunosuppressive Agents Phase 2,Phase 1
21 Antiviral Agents Phase 2
22 Anti-Infective Agents Phase 2
23 Anti-Bacterial Agents Phase 2
24 Topoisomerase Inhibitors Phase 2
25 Immunologic Factors Phase 2,Phase 1
26 Antibiotics, Antitubercular Phase 2
27 Antimetabolites, Antineoplastic Phase 2,Phase 1
28 Antimetabolites Phase 2,Phase 1
29 Alkylating Agents Phase 1, Phase 2
30 Antineoplastic Agents, Alkylating Phase 1, Phase 2
31 Thymoglobulin Phase 1, Phase 2
32 Antilymphocyte Serum Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH Completed NCT01651780 Phase 3 Bivalirudin;Unfractionated Heparin
2 Efficacy of Eltrombopag to Improve Thrombocytopenia of MYH9-related Disease Completed NCT01133860 Phase 2 eltrombopag
3 A Safety and Efficacy Study of Eltrombopag in Subjects With AML Completed NCT01890746 Phase 2 Daunorubicin;Cytarabine;Eltrombopag;Placebo
4 Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation Recruiting NCT03513328 Phase 1, Phase 2 Thiotepa--single daily dose;Thiotepa--escalated dose
5 WEUSKOP5410: Observational Study in ENABLE Clinical Trials Completed NCT01458080 eltrombopag
6 Differential Diagnostic of Immune ThrombocytoPenia (ITP) and Myelodysplastic Syndrome (MDS) Recruiting NCT03469661

Search NIH Clinical Center for Acquired Thrombocytopenia

Genetic Tests for Acquired Thrombocytopenia

Anatomical Context for Acquired Thrombocytopenia

MalaCards organs/tissues related to Acquired Thrombocytopenia:

41
Bone, Heart, Bone Marrow

Publications for Acquired Thrombocytopenia

Articles related to Acquired Thrombocytopenia:

(show all 22)
# Title Authors Year
1
Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). ( 29632238 )
2018
2
The impact of acquired thrombocytopenia on long-term outcomes of patients undergoing elective percutaneous coronary intervention: An analysis of 8,271 consecutive patients. ( 29368387 )
2018
3
Recent advances in understanding and management of acquired thrombocytopenia. ( 29399327 )
2018
4
Correction to: Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). ( 30354600 )
2018
5
Eltrombopag for Delayed Platelet Recovery and Secondary Thrombocytopenia Following Allogeneic Stem Cell Transplantation in Children. ( 30080752 )
2018
6
The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis. ( 27689317 )
2016
7
Non-surgical contraindication for acute appendicitis with secondary thrombocytopenia: a case report. ( 25759558 )
2015
8
Romiplostim for secondary thrombocytopenia following allogeneic stem cell transplantation in children. ( 26084627 )
2015
9
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement. ( 25204308 )
2014
10
Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes. ( 24598983 )
2014
11
Hospital-acquired thrombocytopenia. ( 25502138 )
2014
12
Long-term outcomes associated with hospital acquired thrombocytopenia among patients with non-ST-segment elevation acute coronary syndrome. ( 25066558 )
2014
13
Occurrence and clinical significance of in-hospital acquired thrombocytopenia in patients undergoing transcatheter device closure for congenital heart defect. ( 23026381 )
2012
14
Epidemiology of primary and secondary thrombocytopenia: first analysis of an administrative database in a major Italian institution. ( 22343688 )
2012
15
Incidence and clinical consequences of acquired thrombocytopenia after antithrombotic therapies in patients with acute coronary syndromes: results from the Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) trial. ( 21315212 )
2011
16
Impact of in-hospital acquired thrombocytopenia in patients undergoing primary angioplasty for acute myocardial infarction. ( 16098296 )
2005
17
Congenital and acquired thrombocytopenia. ( 15561694 )
2004
18
Further complexities in diagnosing acquired thrombocytopenia: unexpected parallels between antibody-mediated delayed thrombocytopenia with abciximab and heparin induced thrombocytopenia. ( 15467893 )
2004
19
Secondary thrombocytopenia following phenobarbital treatments in a rhesus monkey (Macaca mulatta). ( 108473 )
1979
20
Platelet size and kinetics in hereditary and acquired thrombocytopenia. ( 5062078 )
1972
21
Transfusions of fresh platelet concentrates to patients with secondary thrombocytopenia. ( 14028146 )
1963
22
Acquired thrombocytopenia following transfusion with bank blood; report of a case. ( 13330381 )
1956

Variations for Acquired Thrombocytopenia

Expression for Acquired Thrombocytopenia

Search GEO for disease gene expression data for Acquired Thrombocytopenia.

Pathways for Acquired Thrombocytopenia

Pathways related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.5 CTNNA1 IL11 THPO
2 11.28 IL11 THPO
3 11.02 IL11 THPO
4 10.61 IL11 THPO

GO Terms for Acquired Thrombocytopenia

Molecular functions related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.96 IL11 THPO
2 growth factor activity GO:0008083 8.62 IL11 THPO

Sources for Acquired Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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