MCID: ACQ005
MIFTS: 36

Acquired Thrombocytopenia

Categories: Blood diseases, Bone diseases, Cancer diseases, Genetic diseases, Immune diseases, Infectious diseases, Rare diseases

Aliases & Classifications for Acquired Thrombocytopenia

MalaCards integrated aliases for Acquired Thrombocytopenia:

Name: Acquired Thrombocytopenia 12 15 70
Secondary Thrombocytopenia 12 54 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11126
ICD9CM 34 287.4
SNOMED-CT 67 74576004
ICD10 32 D69.5
UMLS 70 C0154301

Summaries for Acquired Thrombocytopenia

MalaCards based summary : Acquired Thrombocytopenia, also known as secondary thrombocytopenia, is related to splenic sequestration and purpura. An important gene associated with Acquired Thrombocytopenia is THPO (Thrombopoietin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and JAK-STAT signaling pathway. Affiliated tissues include bone marrow, bone and brain, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Acquired Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 2 Thrombocytopenia 3
Thrombocytopenia 1 Thrombocytopenia 4
Thrombocytopenia 5 Thrombocytopenia 6
Thrombocytopenia 7 Acquired Thrombocytopenia
Thrombocytopenia Due to Platelet Alloimmunization Primary Thrombocytopenia
Ankrd26-Related Thrombocytopenia

Diseases related to Acquired Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 56)
# Related Disease Score Top Affiliating Genes
1 splenic sequestration 29.6 THPO MPL ITGA2B
2 purpura 29.5 THPO MPL ITGA2B GP1BA
3 thrombocytopenia due to platelet alloimmunization 29.5 THPO MPL ITGA2B GP1BA
4 thrombocytopenic purpura, autoimmune 28.9 THPO MPL ITGA2B IL11 GP1BA
5 aplastic anemia 28.8 THPO MPL ITGA2B IL11 GP1BA
6 thrombocytopenia 28.2 THPO MYH9 MPL ITGA2B IL11 GP1BB
7 thrombocytopenia 3 10.2 THPO MPL
8 dyskeratosis congenita, autosomal dominant 6 10.2 THPO MPL
9 sodoku disease 10.2 THPO IL11
10 thrombocythemia 1 10.2 THPO MPL
11 evans' syndrome 10.1 THPO MPL
12 ankrd26-related thrombocytopenia 10.1 MYH9 ANKRD26
13 heparin-induced thrombocytopenia 10.1
14 thrombocytosis 10.0 THPO MPL IL11
15 amegakaryocytic thrombocytopenia, congenital 10.0 THPO MPL ANKRD26
16 autoimmune disease of blood 10.0 THPO MPL ITGA2B
17 arteries, anomalies of 9.9
18 lipoprotein quantitative trait locus 9.9
19 ischemia 9.9
20 neutropenia 9.9 THPO MPL IL11
21 acrokeratoderma, hereditary papulotranslucent 9.9 GP1BB GP1BA
22 bleeding disorder, platelet-type, 11 9.9 ITGA2B GP1BA
23 dengue disease 9.9 THPO IL11
24 pseudo-von willebrand disease 9.9 GP1BB GP1BA
25 thrombasthenia 9.9 ITGA2B GP1BA
26 coronary thrombosis 9.8 ITGA2B GP1BA
27 hematologic cancer 9.8 THPO MPL IL11
28 occlusion precerebral artery 9.8 ITGA2B F11
29 glanzmann thrombasthenia 1 9.8 ITGA2B GP1BA
30 hemolytic uremic syndrome, atypical 1 9.8
31 helicobacter pylori infection 9.8
32 thrombotic thrombocytopenic purpura 9.8
33 disseminated intravascular coagulation 9.8
34 hemolytic-uremic syndrome 9.8
35 acute myocardial infarction 9.8
36 thrombocytopenia-absent radius syndrome 9.7 THPO MPL GP1BB ANKRD26
37 pulmonary fibrosis and/or bone marrow failure, telomere-related, 2 9.7
38 appendicitis 9.7
39 pik3ca-related overgrowth syndrome 9.7
40 fetal and neonatal alloimmune thrombocytopenia 9.7 ITGA2B GP1BB GP1BA
41 primary thrombocytopenia 9.7 THPO MPL ITGA2B GP1BA
42 myeloproliferative syndrome, transient 9.7 THPO MPL ITGA2B GP1BA
43 deficiency anemia 9.7 THPO MPL IL11 GP1BA
44 myelodysplastic syndrome 9.6 THPO MPL ITGA2B IL11 ANKRD26
45 carotid artery thrombosis 9.5 ITGA2B GP1BA F11
46 thrombosis 9.5 ITGA2B GP1BA F11
47 intracranial thrombosis 9.5 ITGA2B GP1BA F11
48 autosomal dominant macrothrombocytopenia 9.5 MYH9 ITGA2B GP1BB GP1BA
49 von willebrand's disease 9.5 ITGA2B GP1BA F11
50 acute megakaryocytic leukemia 9.5 THPO MPL ITGA2B IL11 GP1BA

Comorbidity relations with Acquired Thrombocytopenia via Phenotypic Disease Network (PDN): (show all 25)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Acute Megakaryocytic Leukemia
Alcoholic Liver Cirrhosis Anemia, Autoimmune Hemolytic
Aortic Valve Disease 1 Chronic Kidney Disease
Decubitus Ulcer Deficiency Anemia
Disseminated Intravascular Coagulation Familial Atrial Fibrillation
Heart Disease Hepatic Encephalopathy
Hypersplenism Intermediate Coronary Syndrome
Leukemia, Chronic Lymphocytic Mitral Valve Disease
Neutropenia Oral Candidiasis
Portal Hypertension Primary Thrombocytopenia
Protein-Energy Malnutrition Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2
Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Thrombocytopenia:



Diseases related to Acquired Thrombocytopenia

Symptoms & Phenotypes for Acquired Thrombocytopenia

MGI Mouse Phenotypes related to Acquired Thrombocytopenia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.56 F11 GP1BA GP1BB ITGA2B MPL MYH9
2 homeostasis/metabolism MP:0005376 9.28 ANKRD26 EIF1B F11 GP1BA GP1BB ITGA2B

Drugs & Therapeutics for Acquired Thrombocytopenia

Search Clinical Trials , NIH Clinical Center for Acquired Thrombocytopenia

Genetic Tests for Acquired Thrombocytopenia

Anatomical Context for Acquired Thrombocytopenia

MalaCards organs/tissues related to Acquired Thrombocytopenia:

40
Bone Marrow, Bone, Brain, Heart, Thyroid, Myeloid

Publications for Acquired Thrombocytopenia

Articles related to Acquired Thrombocytopenia:

(show top 50) (show all 121)
# Title Authors PMID Year
1
Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction. 61
33545547 2021
2
Evaluation of Acquired Thrombocytopenia According to the Balloon-Expandable Versus Self-Expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement. 61
32873055 2021
3
Platelet Phenotyping and Function Testing in Thrombocytopenia. 61
33800006 2021
4
[Emergency treatment of severe bleeding in immune thrombocytopenia]. 61
33728478 2021
5
Reply on Evaluation of Acquired Thrombocytopenia According to the Balloon-Expandable Versus Self-Expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement. 61
33256463 2021
6
A Case of Epistaxis as the First Sign of Acute Idiopathic Thrombocytopenic Purpura. 61
33628555 2021
7
Primary Immunodeficiency and Thrombocytopenia. 61
33464134 2021
8
Why thromboembolism occurs in some patients with thrombocytopenia and treatment strategies. 61
33091704 2020
9
Interplay between traumatic brain injury and intimate partner violence: data driven analysis utilizing electronic health records. 61
33287806 2020
10
Impact of acquired thrombocytopenia on cardiovascular outcomes in patients with coronary artery disease undergoing percutaneous coronary intervention: A systematic review and meta-analysis. 61
32800731 2020
11
PERIPHERIAL BLOOD BIOMARKERS IN PATIENTS WITH REFRACTORY IMMUNE THROMBOCYTOPENIA. 61
32672688 2020
12
Thymoma and pure red cell aplasia with hypoplasia of megakaryocytopoiesis: A rare and life-treating condition. 61
31606335 2020
13
Outcomes and Costs Following Ommaya Placement with Thrombocytopenia Among U.S. Patients with Cancer. 61
31866457 2020
14
[Clinical predictive value of short-term dynamic changes in platelet counts for prognosis of sepsis patients in intensive care unit: a retrospective cohort study in adults]. 61
32385993 2020
15
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment. 61
31756253 2020
16
Clopidogrel pretreatment may reduce early acquired thrombocytopenia after transcatheter aortic valve replacement (TAVR). 61
31737991 2019
17
Retrospective evaluation of children with immune thrombocytopenic purpura and factors contributing to chronicity. 61
30470618 2019
18
Prognostic Significance of In-hospital Acquired Thrombocytopenia in Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. 61
31228966 2019
19
Secondary Immune Thrombocytopenic Purpura in Renal Cell Cancer: A Paraneoplastic Syndrome. 61
31245188 2019
20
Hemizygosity for the gene encoding glycoprotein Ibβ is not responsible for macrothrombocytopenia and bleeding in patients with 22q11 deletion syndrome. 61
30549403 2019
21
Eltrombopag for Delayed Platelet Recovery and Secondary Thrombocytopenia Following Allogeneic Stem Cell Transplantation in Children. 61
30080752 2019
22
Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report. 61
31505450 2019
23
Acute myocardial infarction and renal dysfunction due to chronic extreme anemia (hemoglobin 2.5 g/dL) in immune thrombocytopenia. 61
30948994 2018
24
Correction to: Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). 61
30354600 2018
25
Isolated thrombocytopenia in childhood: what if it is not immune thrombocytopenia? 61
30109354 2018
26
Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). 61
29632238 2018
27
The impact of acquired thrombocytopenia on long-term outcomes of patients undergoing elective percutaneous coronary intervention: An analysis of 8,271 consecutive patients. 61
29368387 2018
28
Recent advances in understanding and management of acquired thrombocytopenia. 61
29399327 2018
29
The Epidemiology and Clinical Associations of Stroke in Patients With Acute Myeloid Leukemia: A Review of 10,972 Admissions From the 2012 National Inpatient Sample. 61
29097159 2018
30
Incidence and Outcomes of Heparin-Induced Thrombocytopenia in Patients Undergoing Vascular Surgery. 61
28864160 2017
31
Immune Thrombocytopenia as a Consequence of Rocky Mountain Spotted Fever. 61
29279696 2017
32
The effect of anti-thyroid antibodies positivity on children with primary immune thrombocytopenia. 61
29190168 2017
33
Efficiency and safety of bivalirudin in patients undergoing emergency percutaneous coronary intervention via radial access: A subgroup analysis from the bivalirudin in acute myocardial infarction versus heparin and GPI plus heparin trial. 61
27677411 2017
34
Management of CAD in Patients with Active Cancer: the Interventional Cardiologists' Perspective. 61
28484995 2017
35
Etiology and complications of thrombocytopenia in hospitalized medical patients. 61
28054307 2017
36
Thrombocytopenia and infections. 61
27936979 2017
37
Case of twin pregnancy complicated by idiopathic thrombocytopenic purpura treated with intravenous immunoglobulin: Review of the literature. 61
27958258 2017
38
The effect of in-hospital acquired thrombocytopenia on the outcome of patients with acute coronary syndromes: A systematic review and meta-analysis. 61
27689317 2016
39
Treatment of patients with immune thrombocytopenia admitted to the emergency room. 61
27129318 2016
40
Effect of Baseline Thrombocytopenia on Ischemic Outcomes in Patients With Acute Coronary Syndromes Who Undergo Percutaneous Coronary Intervention. 61
26341303 2016
41
The Incidence, Clinical Outcomes, and Risk Factors of Thrombocytopenia in Intra-Abdominal Infection Patients: A Retrospective Cohort Study. 61
26808492 2016
42
Romiplostim for secondary thrombocytopenia following allogeneic stem cell transplantation in children. 61
26084627 2015
43
Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis). 61
26141452 2015
44
Bivalirudin vs heparin with or without tirofiban during primary percutaneous coronary intervention in acute myocardial infarction: the BRIGHT randomized clinical trial. 61
25775052 2015
45
Macrothrombocytopenia in north India: role of automated platelet data in the detection of an under diagnosed entity. 61
25548447 2015
46
Non-surgical contraindication for acute appendicitis with secondary thrombocytopenia: a case report. 61
25759558 2015
47
Immune Thrombocytopenic Purpura Secondary to Cytomegalovirus Infection: A Case Report. 61
26579523 2015
48
Predictors and clinical impact of pre-existing and acquired thrombocytopenia following transcatheter aortic valve replacement. 61
25204308 2015
49
Acquired thrombocytopenia after transcatheter aortic valve replacement: clinical correlates and association with outcomes. 61
24598983 2014
50
Hospital-acquired thrombocytopenia. 61
25502138 2014

Variations for Acquired Thrombocytopenia

Expression for Acquired Thrombocytopenia

Search GEO for disease gene expression data for Acquired Thrombocytopenia.

Pathways for Acquired Thrombocytopenia

Pathways related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.81 THPO MPL ITGA2B GP1BB GP1BA F11
2
Show member pathways
12.05 THPO MPL IL11
3
Show member pathways
11.83 GP1BB GP1BA F11
4
Show member pathways
11.8 ITGA2B GP1BB GP1BA
5 11.67 ITGA2B GP1BB GP1BA
6 11.62 THPO MPL ITGA2B IL11 GP1BA
7 11.35 THPO ITGA2B IL11 GP1BB GP1BA
8 11.2 ITGA2B GP1BB
9
Show member pathways
11.01 THPO MPL ITGA2B GP1BB GP1BA
10 10.48 GP1BB GP1BA
11 10.32 GP1BB GP1BA

GO Terms for Acquired Thrombocytopenia

Biological processes related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.71 MYH9 ITGA2B GP1BB GP1BA
2 blood coagulation GO:0007596 9.54 GP1BB GP1BA F11
3 hemostasis GO:0007599 9.33 GP1BB GP1BA F11
4 regulation of blood coagulation GO:0030193 9.32 GP1BA F11
5 thrombopoietin-mediated signaling pathway GO:0038163 9.26 THPO MPL
6 blood coagulation, intrinsic pathway GO:0007597 9.13 GP1BB GP1BA F11
7 platelet aggregation GO:0070527 8.92 MYH9 MPL ITGA2B GP1BA

Sources for Acquired Thrombocytopenia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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