MCID: ACQ005
MIFTS: 41

Acquired Thrombocytopenia

Categories: Blood diseases, Bone diseases, Genetic diseases, Immune diseases, Infectious diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Acquired Thrombocytopenia

Summaries for Acquired Thrombocytopenia

MalaCards based summary: Acquired Thrombocytopenia, also known as secondary thrombocytopenia, is related to heparin-induced thrombocytopenia and aplastic anemia. An important gene associated with Acquired Thrombocytopenia is THPO (Thrombopoietin), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Zanubrutinib and Busulfan have been mentioned in the context of this disorder. Affiliated tissues include spleen, myeloid and thyroid, and related phenotypes are homeostasis/metabolism and cellular

Related Diseases for Acquired Thrombocytopenia

Diseases in the Thrombocytopenia family:

Thrombocytopenia 2 Thrombocytopenia 3
Thrombocytopenia 1 Thrombocytopenia 4
Thrombocytopenia 5 Thrombocytopenia 6
Thrombocytopenia 7 Acquired Thrombocytopenia
Thrombocytopenia Due to Platelet Alloimmunization Primary Thrombocytopenia
Ankrd26-Related Thrombocytopenia

Diseases related to Acquired Thrombocytopenia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 94)
# Related Disease Score Top Affiliating Genes
1 heparin-induced thrombocytopenia 29.8 ITGB3 ITGA2B F3
2 aplastic anemia 29.5 THPO MPL IL11 GP1BA
3 splenic sequestration 29.3 THPO MPL ITGA2B F3
4 hemorrhagic disease 29.2 THPO ITGA2B GP1BA F3
5 thrombocytopenic purpura, autoimmune 29.2 THPO MPL ITGB3 ITGA2B IL11 GP1BA
6 purpura 29.0 THPO MPL ITGB3 ITGA2B GP1BA F3
7 qualitative platelet defect 29.0 THPO ITGA2B GP1BA F3 ANKRD26
8 thrombocytopenia due to platelet alloimmunization 28.9 THPO MPL ITGB3 ITGA2B GP1BA F3
9 thrombocytopenia 28.0 THPO NBEAL2 MYH9 MPL ITGB3 ITGA2B
10 thrombotic thrombocytopenic purpura 10.3
11 dyskeratosis congenita, autosomal dominant 6 10.2 THPO MPL
12 thrombocythemia 1 10.2 THPO MPL
13 sodoku disease 10.2 THPO IL11
14 evans' syndrome 10.2 THPO MPL
15 ankrd26-related thrombocytopenia 10.2 MYH9 ANKRD26
16 acrokeratoderma, hereditary papulotranslucent 10.1 GP1BB GP1BA
17 childhood acute megakaryoblastic leukemia 10.1 ITGA2B GP1BA
18 splenic abscess 10.1 THPO F3
19 acquired von willebrand syndrome 10.1 GP1BA F3
20 acquired polycythemia 10.1 MPL F3
21 bleeding disorder, platelet-type, 11 10.1 ITGA2B GP1BA
22 esophageal varix 10.1 THPO F3
23 von willebrand disease, type 1 10.0 GP1BA F3
24 hypersplenism 10.0 THPO F3
25 basilar artery occlusion 10.0 ITGA2B F3
26 bleeding disorder, platelet-type, 16 10.0 ITGB3 ITGA2B
27 splenic disease 10.0 THPO F3
28 malignant gastric germ cell tumor 10.0 ITGB3 ITGA2B
29 gastric teratoma 10.0 ITGB3 ITGA2B
30 intracranial embolism 10.0 ITGA2B F3
31 portal vein thrombosis 10.0 THPO MPL F3
32 occlusion precerebral artery 10.0 ITGA2B F3
33 intracranial thrombosis 9.9 ITGA2B F3
34 hyperlipoproteinemia, type iii 9.9
35 lipoprotein quantitative trait locus 9.9
36 hepatic vascular disease 9.9 THPO F3
37 myelitis 9.9 ITGB3 ITGA2B
38 hemophilia b 9.9 GP1BB GP1BA F3
39 carotid artery thrombosis 9.9 ITGA2B GP1BA F3
40 infective endocarditis 9.9 ITGA2B GP1BA F3
41 intermediate coronary syndrome 9.9 ITGA2B F3
42 vein disease 9.9 THPO F3
43 bleeding disorder, platelet-type, 8 9.9 NBEAL2 GP1BB
44 carotid artery disease 9.9 ITGA2B F3
45 myelodysplastic syndrome 9.8 THPO MPL IL11 GP1BA
46 thrombocytosis 9.8 THPO MPL IL11 F3
47 myeloproliferative neoplasm 9.8 THPO MPL ITGB3 IL11
48 leukemia, chronic myeloid 9.8 THPO MPL ITGB3 IL11
49 radioulnar synostosis 9.8 NBEAL2 MPL ANKRD26
50 arteries, anomalies of 9.8

Comorbidity relations with Acquired Thrombocytopenia via Phenotypic Disease Network (PDN): (show all 24)


Active Peptic Ulcer Disease Acute Cystitis
Acute Kidney Failure Alcoholic Liver Cirrhosis
Anemia, Autoimmune Hemolytic Aortic Valve Disease 1
Chronic Kidney Disease Decubitus Ulcer
Deficiency Anemia Disseminated Intravascular Coagulation
Familial Atrial Fibrillation Heart Disease
Hepatic Encephalopathy Hypersplenism
Intermediate Coronary Syndrome Leukemia, Chronic Lymphocytic
Mitral Valve Disease Neutropenia
Oral Candidiasis Portal Hypertension
Primary Thrombocytopenia Protein-Energy Malnutrition
Pulmonary Fibrosis and/or Bone Marrow Failure, Telomere-Related, 2 Respiratory Failure

Graphical network of the top 20 diseases related to Acquired Thrombocytopenia:



Diseases related to Acquired Thrombocytopenia

Symptoms & Phenotypes for Acquired Thrombocytopenia

MGI Mouse Phenotypes related to Acquired Thrombocytopenia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 ANKRD26 F3 GP1BA GP1BB ITGA2B ITGB3
2 cellular MP:0005384 9.56 F3 GP1BA ITGA2B ITGB3 MPL MYH9
3 hematopoietic system MP:0005397 9.32 F3 GP1BA GP1BB ITGA2B ITGB3 MPL

Drugs & Therapeutics for Acquired Thrombocytopenia

Drugs for Acquired Thrombocytopenia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zanubrutinib Approved, Investigational Phase 2 1691249-45-2 135565884
2
Busulfan Approved, Investigational Phase 1, Phase 2 55-98-1 2478
3
Fludarabine Approved Phase 1, Phase 2 75607-67-9, 21679-14-1 30751 657237
4
Thiotepa Approved, Investigational Phase 1, Phase 2 52-24-4 5453
5 Protein Kinase Inhibitors Phase 2
6 Alkylating Agents Phase 1, Phase 2
7 Antineoplastic Agents, Alkylating Phase 1, Phase 2
8 Antilymphocyte Serum Phase 1, Phase 2
9 Thymoglobulin Phase 1, Phase 2
10 Immunosuppressive Agents Phase 1, Phase 2
11 Immunologic Factors Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Single Arm and Open Clinical Observation of Zanubrutinib in the Treatment of Antiphospholipid Syndrome With Secondary Thrombocytopenia Recruiting NCT05199909 Phase 2 zanubrutinib
2 PEDS024, Phase I/II Feasibility Study of Busulfan Fludarabine and Thiotepa Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation (HSCT) for Children With Non-Malignant Disorders Active, not recruiting NCT03513328 Phase 1, Phase 2 Thiotepa--single daily dose;Thiotepa--escalated dose

Search NIH Clinical Center for Acquired Thrombocytopenia

Genetic Tests for Acquired Thrombocytopenia

Anatomical Context for Acquired Thrombocytopenia

Organs/tissues related to Acquired Thrombocytopenia:

MalaCards : Spleen, Myeloid, Thyroid, Heart, Brain

Publications for Acquired Thrombocytopenia

Articles related to Acquired Thrombocytopenia:

(show top 50) (show all 134)
# Title Authors PMID Year
1
How I use platelet transfusions. 62
35926105 2022
2
Immune thrombocytopenia with clinical significance in systemic lupus erythematosus: a retrospective cohort study of 90 patients. 62
34918048 2022
3
An update on pediatric ITP: differentiating primary ITP, IPD, and PID. 62
34479363 2022
4
Secondary thrombocytopenia after SARS-CoV-2 vaccine: Report of a case of hemorrhage and hematoma after minor oral surgery. 62
34314875 2022
5
Incidence, clinical impact and predictors of thrombocytopenia after transcatheter aortic valve replacement. 62
35124106 2022
6
Downregulation of ADAM17 in pediatric immune thrombocytopenia impairs proplatelet formation. 62
35354403 2022
7
Acid Sphingomyelinase Deficiency: Sharing Experience of Disease Monitoring and Severity in France. 62
35207195 2022
8
Primary Immunodeficiency and Thrombocytopenia. 62
33464134 2022
9
The presence of idiopathic thrombocytopenic purpura correlates with lower rate of acute ST-elevation myocardial infarction. 62
33988030 2021
10
Efficacy and safety of thrombopoietin receptor agonists in the treatment of thrombocytopenia after hematopoietic stem cell transplantation: a meta-analysis and systematic review. 62
34844489 2021
11
Spleen Size and Thrombocytopenia After Transcatheter Aortic Valve Implantation. 62
34404506 2021
12
Immune Thrombocytopenia in Antiphospholipid Syndrome: Is It Primary or Secondary? 62
34572358 2021
13
Using Machine Learning Algorithms to Predict Hospital Acquired Thrombocytopenia after Operation in the Intensive Care Unit: A Retrospective Cohort Study. 62
34573956 2021
14
[Emergency treatment of severe bleeding in immune thrombocytopenia]. 62
33728478 2021
15
Thrombopoietin receptor agonists for acquired thrombocytopenia following anti-CD19 CAR-T-cell therapy: a case report. 62
34272307 2021
16
Impact of Acquired Thrombocytopenia on Cardiovascular Outcomes in Patients With Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis. 62
32800731 2021
17
Platelet transfusion for cancer secondary thrombocytopenia: Platelet and cancer cell interaction. 62
33545547 2021
18
Evaluation of Acquired Thrombocytopenia According to the Balloon-Expandable Versus Self-Expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement. 62
32873055 2021
19
Reply on Evaluation of Acquired Thrombocytopenia According to the Balloon-Expandable Versus Self-Expandable Valves in Patients Undergoing Transcatheter Aortic Valve Replacement. 62
33256463 2021
20
Platelet Phenotyping and Function Testing in Thrombocytopenia. 62
33800006 2021
21
A Case of Epistaxis as the First Sign of Acute Idiopathic Thrombocytopenic Purpura. 62
33628555 2021
22
Why thromboembolism occurs in some patients with thrombocytopenia and treatment strategies. 62
33091704 2020
23
Interplay between traumatic brain injury and intimate partner violence: data driven analysis utilizing electronic health records. 62
33287806 2020
24
PERIPHERIAL BLOOD BIOMARKERS IN PATIENTS WITH REFRACTORY IMMUNE THROMBOCYTOPENIA. 62
32672688 2020
25
Thymoma and pure red cell aplasia with hypoplasia of megakaryocytopoiesis: A rare and life-treating condition. 62
31606335 2020
26
[Clinical predictive value of short-term dynamic changes in platelet counts for prognosis of sepsis patients in intensive care unit: a retrospective cohort study in adults]. 62
32385993 2020
27
Outcomes and Costs Following Ommaya Placement with Thrombocytopenia Among U.S. Patients with Cancer. 62
31866457 2020
28
Identifying and treating refractory ITP: difficulty in diagnosis and role of combination treatment. 62
31756253 2020
29
Clopidogrel pretreatment may reduce early acquired thrombocytopenia after transcatheter aortic valve replacement (TAVR). 62
31737991 2019
30
Retrospective evaluation of children with immune thrombocytopenic purpura and factors contributing to chronicity. 62
30470618 2019
31
Prognostic Significance of In-hospital Acquired Thrombocytopenia in Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention. 62
31228966 2019
32
Secondary Immune Thrombocytopenic Purpura in Renal Cell Cancer: A Paraneoplastic Syndrome. 62
31245188 2019
33
Hemizygosity for the gene encoding glycoprotein Ibβ is not responsible for macrothrombocytopenia and bleeding in patients with 22q11 deletion syndrome. 62
30549403 2019
34
Combined subtotal gastrectomy and splenectomy after partial splenic embolization for a patient with gastric cancer and immune thrombocytopenic purpura: A case report. 62
31505450 2019
35
Eltrombopag for Delayed Platelet Recovery and Secondary Thrombocytopenia Following Allogeneic Stem Cell Transplantation in Children. 62
30080752 2019
36
Acute myocardial infarction and renal dysfunction due to chronic extreme anemia (hemoglobin 2.5 g/dL) in immune thrombocytopenia. 62
30948994 2018
37
Correction to: Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). 62
30354600 2018
38
Isolated thrombocytopenia in childhood: what if it is not immune thrombocytopenia? 62
30109354 2018
39
Incidence, Predictors, and Outcomes of Acquired Thrombocytopenia After Percutaneous Coronary Intervention: A Pooled, Patient-Level Analysis of the CHAMPION Trials (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition). 62
29632238 2018
40
The impact of acquired thrombocytopenia on long-term outcomes of patients undergoing elective percutaneous coronary intervention: An analysis of 8,271 consecutive patients. 62
29368387 2018
41
The Epidemiology and Clinical Associations of Stroke in Patients With Acute Myeloid Leukemia: A Review of 10,972 Admissions From the 2012 National Inpatient Sample. 62
29097159 2018
42
Recent advances in understanding and management of acquired thrombocytopenia. 62
29399327 2018
43
Incidence and Outcomes of Heparin-Induced Thrombocytopenia in Patients Undergoing Vascular Surgery. 62
28864160 2017
44
Immune Thrombocytopenia as a Consequence of Rocky Mountain Spotted Fever. 62
29279696 2017
45
The effect of anti-thyroid antibodies positivity on children with primary immune thrombocytopenia. 62
29190168 2017
46
Efficiency and safety of bivalirudin in patients undergoing emergency percutaneous coronary intervention via radial access: A subgroup analysis from the bivalirudin in acute myocardial infarction versus heparin and GPI plus heparin trial. 62
27677411 2017
47
Management of CAD in Patients with Active Cancer: the Interventional Cardiologists' Perspective. 62
28484995 2017
48
Etiology and complications of thrombocytopenia in hospitalized medical patients. 62
28054307 2017
49
Thrombocytopenia and infections. 62
27936979 2017
50
Case of twin pregnancy complicated by idiopathic thrombocytopenic purpura treated with intravenous immunoglobulin: Review of the literature. 62
27958258 2017

Variations for Acquired Thrombocytopenia

Expression for Acquired Thrombocytopenia

Search GEO for disease gene expression data for Acquired Thrombocytopenia.

Pathways for Acquired Thrombocytopenia

GO Terms for Acquired Thrombocytopenia

Cellular components related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.96 MPL ITGB3 ITGA2B GP1BA F3
2 external side of plasma membrane GO:0009897 9.56 MPL ITGB3 ITGA2B GP1BA F3
3 platelet alpha granule membrane GO:0031092 9.46 ITGB3 ITGA2B
4 glycoprotein Ib-IX-V complex GO:1990779 8.92 GP1BB GP1BA

Biological processes related to Acquired Thrombocytopenia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 10.1 MYH9 ITGB3 ITGA2B GP1BB GP1BA
2 integrin-mediated signaling pathway GO:0007229 9.99 MYH9 ITGB3 ITGA2B
3 platelet activation GO:0030168 9.88 GP1BA GP1BB ITGB3
4 platelet formation GO:0030220 9.83 NBEAL2 MYH9
5 release of sequestered calcium ion into cytosol GO:0051209 9.8 RASA3 GP1BB GP1BA
6 megakaryocyte differentiation GO:0030219 9.78 THPO IL11
7 positive regulation of platelet activation GO:0010572 9.76 GP1BB GP1BA
8 blood coagulation, intrinsic pathway GO:0007597 9.73 GP1BB GP1BA
9 thrombopoietin-mediated signaling pathway GO:0038163 9.67 THPO MPL
10 megakaryocyte development GO:0035855 9.63 THPO GP1BB GP1BA
11 blood coagulation GO:0007596 9.5 ITGB3 GP1BB GP1BA F3
12 hemostasis GO:0007599 9.43 GP1BB GP1BA F3
13 platelet aggregation GO:0070527 9.23 MYH9 MPL ITGB3 GP1BA

Sources for Acquired Thrombocytopenia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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