MCID: ACR014
MIFTS: 50

Acral Lentiginous Melanoma

Categories: Cancer diseases, Rare diseases, Skin diseases

Aliases & Classifications for Acral Lentiginous Melanoma

MalaCards integrated aliases for Acral Lentiginous Melanoma:

Name: Acral Lentiginous Melanoma 12 54 15
Acral Lentiginous Malignant Melanoma of Skin 54
Acral Lentiginous Melanoma, Malignant 12
Malignant Acral Lentiginous Melanoma 12
Acral Lentiginous Malignant Melanoma 74
Palmar/plantar Melanoma 54
Subungual Melanoma 54
Alm 54

Classifications:



External Ids:

Disease Ontology 12 DOID:6367
UMLS 74 C0346037

Summaries for Acral Lentiginous Melanoma

NIH Rare Diseases : 54 Acral lentiginous melanoma (ALM) is a type of melanoma that occurs on the palms of the hands or the soles of the feet. The condition can develop in normal-appearing skin or within an existing mole. ALM begins as a flat patch of discolored skin that may enlarge slowly over time. Although the cancercells often remain contained at the skins surface (epidermis) initially, ALM can become invasive and spread as the condition advances. Like other flat forms of melanoma, it can be recognized by the ABCDE rule. Although ALM affects men and women of all skin colors equally, is it most commonly diagnosed in people over age 40. The underlying cause of ALM is poorly understood. It is not related to sun exposure like other forms of skin cancer. Initial treatment generally consists of surgery to remove the skin lesion. Additional therapy (such as radiation therapy or immunotherapy) may then be recommended depending on the severity of the condition.

MalaCards based summary : Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to squamous cell carcinoma and mucosal melanoma, and has symptoms including macule An important gene associated with Acral Lentiginous Melanoma is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Dacarbazine and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and thyroid, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Disease Ontology : 12 A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.

Wikipedia : 77 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. Melanoma is a serious skin cancer... more...

Related Diseases for Acral Lentiginous Melanoma

Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 29.9 BRAF CDKN2A MUC1
2 mucosal melanoma 29.7 BRAF KIT NRAS TERT
3 myeloma, multiple 29.6 BRAF CDKN2A KIT NRAS
4 alstrom syndrome 11.9
5 melanoma 11.2
6 lentigines 10.4
7 systemic lupus erythematosus 10.3
8 melanoma in congenital melanocytic nevus 10.3
9 sarcoma 10.3
10 dermatophytosis 10.3
11 ovarian melanoma 10.2 KIT NRAS
12 conventional fibrosarcoma 10.2 KIT NRAS
13 malignant spindle cell melanoma 10.2 KIT NRAS
14 bowenoid papulosis 10.2 CDKN2A TERT
15 congenital mesoblastic nephroma 10.2 KIT NRAS
16 melanomatosis 10.2 CDKN2A NRAS
17 malignant skin fibrous histiocytoma 10.2 KIT NRAS
18 core binding factor acute myeloid leukemia 10.2 KIT NRAS
19 malignant dermis tumor 10.2 KIT NRAS
20 reticular perineurioma 10.2 KIT MUC1
21 perineurioma 10.2 KIT MUC1
22 meningeal melanomatosis 10.2 CDKN2A NRAS
23 adenoid basal cell carcinoma 10.2 CDKN2A KIT
24 mixed ductal-endocrine carcinoma 10.2 MUC1 TERT
25 aggressive digital papillary adenocarcinoma 10.2 KIT MUC1
26 lymphoepithelioma-like thymic carcinoma 10.2 CDKN2A KIT
27 sarcomatoid renal cell carcinoma 10.2 KIT MUC1
28 perivascular epithelioid cell tumor 10.1 KIT MUC1
29 dermoid cyst 10.1 KIT MUC1
30 malignant peritoneal mesothelioma 10.1 CDKN2A MUC1
31 ewing's family of tumors 10.1 CDKN2A KIT
32 peritoneal mesothelioma 10.1 CDKN2A MUC1
33 gastric cardia carcinoma 10.1 KIT MUC1
34 kaposi sarcoma 10.1
35 werner syndrome 10.1
36 basal cell carcinoma 1 10.1
37 psoriatic arthritis 10.1
38 arthritis 10.1
39 nodular malignant melanoma 10.1
40 tinea pedis 10.1
41 plantar wart 10.1
42 phaeohyphomycosis 10.1
43 basal cell carcinoma 10.1
44 palmoplantar keratosis 10.1
45 skin carcinoma 10.1
46 clear cell sarcoma 10.1
47 tinea nigra 10.1
48 lichen planus 10.1
49 degos 'en cocarde' erythrokeratoderma 10.1
50 lentigo maligna melanoma 10.1

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to Acral Lentiginous Melanoma

Symptoms & Phenotypes for Acral Lentiginous Melanoma

UMLS symptoms related to Acral Lentiginous Melanoma:


macule

GenomeRNAi Phenotypes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.23 KIT MET
2 Decreased substrate adherent cell growth GR00193-A-2 9.23 KIT
3 Decreased substrate adherent cell growth GR00193-A-3 9.23 BRAF MET
4 Decreased substrate adherent cell growth GR00193-A-4 9.23 BRAF KIT MET

MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

47 (show all 14)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.01 BRAF CDKN2A KIT MET NRAS TERT
2 digestive/alimentary MP:0005381 10 BRAF CDKN2A KIT MET NRAS TERT
3 endocrine/exocrine gland MP:0005379 9.97 BRAF CDKN2A KIT MET NRAS TERT
4 growth/size/body region MP:0005378 9.95 BRAF CDKN2A KIT MET NRAS TERT
5 immune system MP:0005387 9.93 BRAF CDKN2A KIT MET NRAS TERT
6 embryo MP:0005380 9.91 BRAF CDKN2A KIT MET NRAS
7 neoplasm MP:0002006 9.85 BRAF CDKN2A KIT MET NRAS TERT
8 liver/biliary system MP:0005370 9.8 BRAF CDKN2A KIT MET NRAS
9 limbs/digits/tail MP:0005371 9.73 BRAF KIT MET NRAS
10 normal MP:0002873 9.72 BRAF KIT MET NRAS TERT
11 pigmentation MP:0001186 9.56 BRAF CDKN2A KIT NRAS
12 respiratory system MP:0005388 9.55 BRAF CDKN2A KIT MET TERT
13 skeleton MP:0005390 9.35 BRAF CDKN2A KIT NRAS TERT
14 vision/eye MP:0005391 9.02 BRAF CDKN2A KIT MET NRAS

Drugs & Therapeutics for Acral Lentiginous Melanoma

Drugs for Acral Lentiginous Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 24)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dacarbazine Approved, Investigational Phase 3 4342-03-4 5351166
2 Immunoglobulins Phase 3,Phase 2
3 Antibodies, Monoclonal Phase 3,Phase 2
4 Antineoplastic Agents, Immunological Phase 3,Phase 2,Phase 1
5 Antibodies Phase 3,Phase 2
6 Immunologic Factors Phase 3,Phase 2
7
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
8
Pembrolizumab Approved Phase 2 1374853-91-4
9
Ipilimumab Approved Phase 2 477202-00-9
10
nivolumab Approved Phase 2,Phase 1 946414-94-4
11
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
12
Tyrosine Approved, Investigational, Nutraceutical Phase 2 60-18-4 6057
13
Cediranib Investigational Phase 2 288383-20-0 9933475
14
Maleic acid Experimental, Investigational Phase 2 110-17-8, 110-16-7 444972
15 Angiogenesis Inhibitors Phase 2
16 Protein Kinase Inhibitors Phase 2
17 Angiogenesis Modulating Agents Phase 2
18 Imatinib Mesylate Phase 2 220127-57-1 123596
19 Immunoglobulin G Phase 2
20
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
21 Anti-Infective Agents Phase 1
22 Ganciclovir triphosphate Phase 1
23 Antiviral Agents Phase 1
24 Nucleic Acid Synthesis Inhibitors Phase 1

Interventional clinical trials:

(show all 17)
# Name Status NCT ID Phase Drugs
1 A Phase Ⅲ Study to Investigate JS001 Versus Dacarbazine as the First Line Therapy for Unresectable or Metastatic Melanoma Recruiting NCT03430297 Phase 3 Dacarbazine 1000mg/m2 Q3W
2 A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread Completed NCT01395121 Phase 2 nilotinib
3 SU011248 in Patients With Metastatic Mucosal or Acral/Lentiginous Melanoma Completed NCT00577382 Phase 2 Sunitinib
4 Imatinib Mesylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery Completed NCT00470470 Phase 2 imatinib mesylate
5 AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma Completed NCT00243061 Phase 2 cediranib maleate
6 Pembrolizumab in Advanced/Metastatic Acral Lentiginous Melanoma Recruiting NCT02875132 Phase 2 pembrolizumab
7 A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab Recruiting NCT02978443 Phase 2 Nivolumab;Ipilimumab
8 Nivolumab With or Without Ipilimumab or Relatlimab Before Surgery in Treating Patients With Stage IIIB-IV Melanoma That Can Be Removed by Surgery Recruiting NCT02519322 Phase 2
9 Pembrolizumab in Treating Patients With Stage III-IV High-Risk Melanoma Before and After Surgery Recruiting NCT03698019 Phase 2
10 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
11 Dasatinib in Treating Patients With Locally Advanced or Metastatic Mucosal Melanoma, Acral Melanoma, or Vulvovaginal Melanoma That Cannot Be Removed By Surgery Active, not recruiting NCT00700882 Phase 2 dasatinib
12 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
13 Treatment With Dasatinib in Patients With Acral Lentiginous, Mucosal, or Chronic Sun-damaged Melanoma Terminated NCT01092728 Phase 2 Dasatinib
14 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
15 Intravenous and Intrathecal Nivolumab in Treating Patients With Leptomeningeal Disease Recruiting NCT03025256 Phase 1
16 Study of Families With Melanoma Recruiting NCT00445783
17 French Clinical Datbase of Melanoma Patients (RIC-Mel) Recruiting NCT03315468

Search NIH Clinical Center for Acral Lentiginous Melanoma

Genetic Tests for Acral Lentiginous Melanoma

Anatomical Context for Acral Lentiginous Melanoma

MalaCards organs/tissues related to Acral Lentiginous Melanoma:

42
Skin, Brain, Thyroid, Lung, Bone, Myeloid, Lymph Node

Publications for Acral Lentiginous Melanoma

Articles related to Acral Lentiginous Melanoma:

(show top 50) (show all 151)
# Title Authors Year
1
Acral Lentiginous Melanoma: Survival Analysis of 715 Cases. ( 30221995 )
2019
2
Efficacy of nivolumab monotherapy against acral lentiginous melanoma and mucosal melanoma in Asian patients. ( 30447078 )
2019
3
Childhood onset atrophic plaque on the chest of a woman with history of acral lentiginous melanoma. ( 30609013 )
2019
4
The Misdiagnosis of Acral Lentiginous Melanoma: Three Case Presentations. ( 30649902 )
2019
5
A pink enlarging plaque on the plantar foot: amelanotic acral lentiginous melanoma. ( 30710904 )
2019
6
Relationship between tumor-associated immune infiltrate and p16 staining over clinicopathological features in acral lentiginous melanoma. ( 30778854 )
2019
7
Does sentinel lymph node status have prognostic significance in patients with acral lentiginous melanoma? ( 30883783 )
2019
8
Acral lentiginous melanoma: a skin cancer with unfavourable prognostic features. A study of the German central malignant melanoma registry (CMMR) in 2050 patients. ( 28707317 )
2018
9
Insulin-like growth factor-2 mRNA-binding protein 3 as a novel prognostic biomarker for acral lentiginous melanoma. ( 29048737 )
2018
10
High density of M2-macrophages in acral lentiginous melanoma compared to superficial spreading melanoma. ( 29415335 )
2018
11
Prognostic features for acral lentiginous melanoma. ( 29441559 )
2018
12
Clinical features and prognosis of Asian patients with acral lentiginous melanoma who have nodal nevi in their sentinel lymph node biopsy specimen. ( 29673774 )
2018
13
Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis. ( 29785333 )
2018
14
Metastatic acral lentiginous melanoma in a tertiary referral center in Switzerland: a systematic analysis. ( 29847461 )
2018
15
Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival. ( 29860247 )
2018
16
Acral lentiginous melanoma. ( 29900875 )
2018
17
Diagnosis and Management of Acral Lentiginous Melanoma. ( 29951919 )
2018
18
Feasibility of IMP-3 as an Invasiveness Marker for Acral Lentiginous Melanoma. ( 30065600 )
2018
19
Strategies for Reducing Diagnostic Delay in Acral Lentiginous Melanoma. ( 30122615 )
2018
20
Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia. ( 27518480 )
2017
21
Histopathological diagnosis of acral lentiginous melanoma in early stages. ( 27601330 )
2017
22
Double Primary Acral Lentiginous Melanoma of both Soles. ( 28223769 )
2017
23
Multiple Primary Acral Lentiginous Melanoma on the Feet Developing in Lesions of Nagashima-type Palmoplantar Keratoderma. ( 28224164 )
2017
24
Acral lentiginous melanoma versus other melanoma: A single-center analysis in Japan. ( 28342269 )
2017
25
Prognostic factors and survival in acral lentiginous melanoma. ( 28432682 )
2017
26
Acral Lentiginous Melanoma, Indolent Subtype Diagnosed by En Bloc Excision: A Case Report. ( 28566910 )
2017
27
Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma. ( 28567312 )
2017
28
Tumor infiltrating lymphocytes in acral lentiginous melanoma: a study of a large cohort of cases from Latin America. ( 28577153 )
2017
29
Overexpression of Human Leukocyte Antigen-G and Interleukin 10 in acral lentiginous melanoma. ( 28587737 )
2017
30
The role of access to care in acral lentiginous melanoma survival. ( 28833024 )
2017
31
Acral lentiginous melanoma with dematiaceous fungal elements of Chaetomium globosum: A saprophytism or coexistence of superficial phaeohyphomycosis? ( 28836689 )
2017
32
Laryngeal metastases of acral lentiginous melanoma: Narrow band imaging. ( 25488159 )
2016
33
Reconstruction of large wounds using a combination of negative pressure wound therapy and punch grafting after excision of acral lentiginous melanoma on the foot. ( 26173565 )
2016
34
Reflectance confocal microscopy features of acral lentiginous melanoma: a comparative study with acral nevi. ( 26428577 )
2016
35
Acral Lentiginous Melanoma. ( 26601870 )
2016
36
Amelanotic acral lentiginous melanoma mimicking diabetic ulcer: a challenge to diagnose and treat. ( 26679765 )
2016
37
Insulin-Like Growth Factor II mRNA-Binding Protein 3 Expression Correlates with Poor Prognosis in Acral Lentiginous Melanoma. ( 26796627 )
2016
38
Hidden acral lentiginous melanoma with cutaneous metastases masquerading as Kaposi's sarcoma in an HIV-positive Indian man. ( 26838298 )
2016
39
Rare cause of non-healing foot wound--acral lentiginous melanoma. ( 26994380 )
2016
40
Erratum to «Laryngeal metastases of acral lentiginous melanoma: Narrow band imaging». ( 27393792 )
2016
41
Acral lentiginous melanoma with multiple brain metastases in an Indian male. ( 27559525 )
2016
42
Indolent subtype acral lentiginous melanoma with long radial growth phase: a dermatopathological pitfall. ( 25072690 )
2015
43
Acral lentiginous melanoma treated with topical imiquimod cream: possible cooperation between drug and tumour cells. ( 25252087 )
2015
44
Two Spanish cases of atypical melanosis of the foot, an early stage of acral lentiginous melanoma in situ. ( 25323966 )
2015
45
Acral lentiginous melanoma: who benefits from sentinel lymph node biopsy? ( 25455840 )
2015
46
The distribution pattern of HMB-45-positive cells is helpful for the diagnosis of early acral lentiginous melanoma in situ. ( 25773399 )
2015
47
Acral lentiginous melanoma of the foot misdiagnosed as a traumatic ulcer. A cautionary case. ( 25815661 )
2015
48
Screening for Acral Lentiginous Melanoma in Dark-Skinned Individuals. ( 26083954 )
2015
49
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma. ( 26088594 )
2015
50
IMAGES IN CLINICAL MEDICINE. Acral Lentiginous Melanoma. ( 26535515 )
2015

Variations for Acral Lentiginous Melanoma

Cosmic variations for Acral Lentiginous Melanoma:

9 (show top 50) (show all 155)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM6939025 TP63 skin,NS,malignant melanoma,acral lentiginous c.1510C>G p.P504A 3:189889342-189889342 0
2 COSM6951885 SETD2 skin,subungual,malignant melanoma,acral lentiginous c.3083C>G p.S1028C 3:47113999-47113999 0
3 COSM29529 RB1 skin,NS,malignant melanoma,acral lentiginous c.1411C>T p.Q471* 13:48380074-48380074 0
4 COSM6936562 RAF1 skin,NS,malignant melanoma,acral lentiginous c.626T>C p.L209P 3:12606255-12606255 0
5 COSM5413434 RAF1 skin,NS,malignant melanoma,acral lentiginous c.1472C>T p.T491I 3:12585745-12585745 0
6 COSM6889946 PTPRT skin,NS,malignant melanoma,acral lentiginous c.2431G>A p.E811K 20:42199366-42199366 0
7 COSM6936567 PTPRS skin,NS,malignant melanoma,acral lentiginous c.3707T>C p.L1236P 19:5219997-5219997 0
8 COSM1166809 PTEN skin,acral,malignant melanoma,acral lentiginous c.333G>A p.W111* 10:87933092-87933092 0
9 COSM6943320 PTCH1 skin,NS,malignant melanoma,acral lentiginous c.344G>T p.G115V 9:95506457-95506457 0
10 COSM6921633 PRKN skin,NS,malignant melanoma,acral lentiginous c.1210G>A p.E404K 6:161360163-161360163 0
11 COSM6954881 POLE skin,NS,malignant melanoma,acral lentiginous c.3541A>G p.K1181E 12:132657177-132657177 0
12 COSM6921634 PMS2 skin,NS,malignant melanoma,acral lentiginous c.640G>A p.V214M 7:5999173-5999173 0
13 COSM6943848 PLCG2 skin,NS,malignant melanoma,acral lentiginous c.3094G>A p.G1032R 16:81937799-81937799 0
14 COSM228367 PIK3CB skin,NS,malignant melanoma,acral lentiginous c.3200A>T p.D1067V 3:138655402-138655402 0
15 COSM776 PIK3CA skin,subungual,malignant melanoma,acral lentiginous c.3140A>T p.H1047L 3:179234297-179234297 0
16 COSM6925493 PIK3C2G skin,subungual,malignant melanoma,acral lentiginous c.2381G>A p.W794* 12:18424039-18424039 0
17 COSM6922385 NTRK3 skin,NS,malignant melanoma,acral lentiginous c.1831G>A p.D611N 15:87933070-87933070 0
18 COSM6914116 NTRK2 skin,NS,malignant melanoma,acral lentiginous c.2219G>T p.S740I 9:85020252-85020252 0
19 COSM564 NRAS skin,NS,malignant melanoma,acral lentiginous c.35G>A p.G12D 1:114716126-114716126 0
20 COSM565 NRAS skin,NS,malignant melanoma,acral lentiginous c.35G>C p.G12A 1:114716126-114716126 0
21 COSM3724522 NRAS skin,NS,malignant melanoma,acral lentiginous c.184G>C p.E62Q 1:114713906-114713906 0
22 COSM584 NRAS skin,NS,malignant melanoma,acral lentiginous c.182A>G p.Q61R 1:114713908-114713908 0
23 COSM586 NRAS skin,NS,malignant melanoma,acral lentiginous c.183A>C p.Q61H 1:114713907-114713907 0
24 COSM583 NRAS skin,NS,malignant melanoma,acral lentiginous c.182A>T p.Q61L 1:114713908-114713908 0
25 COSM573 NRAS skin,NS,malignant melanoma,acral lentiginous c.38G>A p.G13D 1:114716123-114716123 0
26 COSM566 NRAS skin,NS,malignant melanoma,acral lentiginous c.35G>T p.G12V 1:114716126-114716126 0
27 COSM580 NRAS skin,NS,malignant melanoma,acral lentiginous c.181C>A p.Q61K 1:114713909-114713909 0
28 COSM563 NRAS skin,NS,malignant melanoma,acral lentiginous c.34G>A p.G12S 1:114716127-114716127 0
29 COSM569 NRAS skin,acral,malignant melanoma,NS c.37G>C p.G13R 1:114716124-114716124 0
30 COSM562 NRAS skin,acral,malignant melanoma,acral lentiginous c.34G>T p.G12C 1:114716127-114716127 0
31 COSM253327 NRAS skin,acral,malignant melanoma,NS c.176C>A p.A59D 1:114713914-114713914 0
32 COSM577 NRAS skin,NS,malignant melanoma,acral lentiginous c.52G>A p.A18T 1:114716109-114716109 0
33 COSM6945207 NOTCH1 skin,subungual,malignant melanoma,acral lentiginous c.5828C>T p.A1943V 9:136500658-136500658 0
34 COSM22301 NF2 skin,NS,malignant melanoma,acral lentiginous c.1340+1G>A p.? 22:29673487-29673487 0
35 COSM6914119 NF1 skin,NS,malignant melanoma,acral lentiginous c.7732G>T p.E2578* 17:31356576-31356576 0
36 COSM36883 NF1 skin,NS,malignant melanoma,acral lentiginous c.5305C>T p.R1769* 17:31327535-31327535 0
37 COSM6925488 MUTYH skin,subungual,malignant melanoma,acral lentiginous c.1435C>A p.H479N 1:45331214-45331214 0
38 COSM6943318 MST1R skin,NS,malignant melanoma,acral lentiginous c.4171C>T p.R1391W 3:49887339-49887339 0
39 COSM6925489 MSH6 skin,subungual,malignant melanoma,acral lentiginous c.3731T>A p.L1244* 2:47806288-47806288 0
40 COSM6921159 MSH6 skin,NS,malignant melanoma,acral lentiginous c.1186C>G p.L396V 2:47799169-47799169 0
41 COSM522 KRAS skin,NS,malignant melanoma,acral lentiginous c.35G>C p.G12A 12:25245350-25245350 0
42 COSM521 KRAS skin,NS,malignant melanoma,acral lentiginous c.35G>A p.G12D 12:25245350-25245350 0
43 COSM1304 KIT skin,acral,malignant melanoma,NS c.1924A>G p.K642E 4:54728055-54728055 0
44 COSM1257 KIT skin,acral,malignant melanoma,acral lentiginous c.1679T>A p.V560D 4:54727447-54727447 0
45 COSM1290 KIT skin,NS,malignant melanoma,acral lentiginous c.1727T>C p.L576P 4:54727495-54727495 0
46 COSM133755 KIT skin,acral,malignant melanoma,NS c.1469A>G p.E490G 4:54725979-54725979 0
47 COSM1430154 KIT skin,acral,malignant melanoma,acral lentiginous c.1715A>G p.D572G 4:54727483-54727483 0
48 COSM133767 KIT skin,acral,malignant melanoma,NS c.2558G>A p.W853* 4:54736571-54736571 0
49 COSM133763 KIT skin,acral,malignant melanoma,NS c.1657T>A p.Y553N 4:54727425-54727425 0
50 COSM6503446 KIT skin,acral,malignant melanoma,acral lentiginous c.1733A>G p.Y578C 4:54727501-54727501 0

Expression for Acral Lentiginous Melanoma

Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for Acral Lentiginous Melanoma

Pathways related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.51 BRAF CDKN2A KIT MET NRAS TERT
2
Show member pathways
13.47 BRAF CDKN2A KIT MET MUC1 NRAS
3
Show member pathways
13.42 BRAF CDKN2A KIT MET NRAS
4
Show member pathways
13.41 BRAF KIT MET MUC1 NRAS
5
Show member pathways
13 BRAF KIT MET NRAS
6
Show member pathways
13 BRAF KIT MET MUC1 NRAS
7
Show member pathways
12.77 BRAF KIT MET NRAS
8
Show member pathways
12.68 KIT MET NRAS TERT
9
Show member pathways
12.63 BRAF KIT MET NRAS
10
Show member pathways
12.56 BRAF CDKN2A KIT NRAS
11 12.4 BRAF KIT MET NRAS
12
Show member pathways
12.35 BRAF CDKN2A MET NRAS
13
Show member pathways
12.35 BRAF KIT MET NRAS
14
Show member pathways
12.34 BRAF MET NRAS
15
Show member pathways
12.29 BRAF MUC1 NRAS
16 12.27 CDKN2A MET NRAS
17
Show member pathways
12.26 BRAF MET NRAS
18 12.16 BRAF CDKN2A KIT MET NRAS TERT
19 12.11 CDKN2A NRAS TERT
20
Show member pathways
12.07 BRAF KIT MET NRAS
21
Show member pathways
12.02 KIT MET TERT
22 12.02 BRAF MET NRAS
23
Show member pathways
11.96 BRAF MET NRAS
24
Show member pathways
11.77 BRAF CDKN2A KIT MET NRAS TERT
25 11.59 BRAF CDKN2A NRAS
26 11.43 BRAF NRAS
27
Show member pathways
11.42 BRAF KIT NRAS
28 11.3 BRAF CDKN2A NRAS
29 11.26 BRAF NRAS
30 11.14 BRAF NRAS
31 11.14 KIT MET NRAS
32 11.06 MET NRAS

GO Terms for Acral Lentiginous Melanoma

Biological processes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 peptidyl-tyrosine phosphorylation GO:0018108 9.54 BRAF KIT MET
2 somatic stem cell population maintenance GO:0035019 9.49 BRAF KIT
3 visual learning GO:0008542 9.48 BRAF KIT
4 negative regulation of endothelial cell apoptotic process GO:2000352 9.46 BRAF TERT
5 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.43 BRAF KIT
6 response to cadmium ion GO:0046686 9.4 KIT TERT
7 negative regulation of apoptotic process GO:0043066 9.32 BRAF TERT
8 replicative senescence GO:0090399 9.26 CDKN2A TERT
9 somatic stem cell division GO:0048103 9.16 CDKN2A KIT
10 myeloid progenitor cell differentiation GO:0002318 8.96 BRAF KIT
11 MAPK cascade GO:0000165 8.92 BRAF KIT MET NRAS

Molecular functions related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.16 KIT MET
2 protein tyrosine kinase activity GO:0004713 9.13 BRAF KIT MET
3 nucleotide binding GO:0000166 8.92 BRAF KIT MET NRAS

Sources for Acral Lentiginous Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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