MCID: ACR014
MIFTS: 49

Acral Lentiginous Melanoma

Categories: Rare diseases, Cancer diseases, Skin diseases

Aliases & Classifications for Acral Lentiginous Melanoma

MalaCards integrated aliases for Acral Lentiginous Melanoma:

Name: Acral Lentiginous Melanoma 12 53 15
Acral Lentiginous Malignant Melanoma of Skin 53
Acral Lentiginous Melanoma, Malignant 12
Malignant Acral Lentiginous Melanoma 12
Acral Lentiginous Malignant Melanoma 73
Palmar/plantar Melanoma 53
Subungual Melanoma 53
Alm 53

Classifications:



External Ids:

Disease Ontology 12 DOID:6367
UMLS 73 C0346037

Summaries for Acral Lentiginous Melanoma

NIH Rare Diseases : 53 Acral lentiginous melanoma (ALM) is a type of melanoma that occurs on the palms of the hands or the soles of the feet. The condition can develop in normal-appearing skin or within an existing mole. ALM begins as a flat patch of discolored skin that may enlarge slowly over time. Although the cancercells often remain contained at the skins surface (epidermis) initially, ALM can become invasive and spread as the condition advances. Like other flat forms of melanoma, it can be recognized by the ABCDE rule. Although ALM affects men and women of all skin colors equally, is it most commonly diagnosed in people over age 40. The underlying cause of ALM is poorly understood. It is not related to sun exposure like other forms of skin cancer. Initial treatment generally consists of surgery to remove the skin lesion. Additional therapy (such as radiation therapy or immunotherapy) may then be recommended depending on the severity of the condition.

MalaCards based summary : Acral Lentiginous Melanoma, also known as acral lentiginous malignant melanoma of skin, is related to melanoma and myeloma, multiple, and has symptoms including macule An important gene associated with Acral Lentiginous Melanoma is NRAS (NRAS Proto-Oncogene, GTPase), and among its related pathways/superpathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. The drugs Sunitinib and Pembrolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and brain, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

Disease Ontology : 12 A skin melanoma that is characterized by slow growth of a small pigmented spot on the skin with a clearly defined edge, surrounded by normal-appearing skin and occurs on occurs on non hair-bairing surfaces including hands and feet, subungual sites, and fingers or toes.

Wikipedia : 76 Acral lentiginous melanoma is a kind of lentiginous skin melanoma. Melanoma is a serious skin cancer... more...

Related Diseases for Acral Lentiginous Melanoma

Diseases related to Acral Lentiginous Melanoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 melanoma 30.1 BRAF CDKN2A NRAS PTEN
2 myeloma, multiple 29.6 BRAF CDKN2A NRAS
3 alstrom syndrome 11.2
4 lentigines 11.1
5 malignant spindle cell melanoma 10.4 KIT NRAS
6 conventional fibrosarcoma 10.4 KIT NRAS
7 bowenoid papulosis 10.4 CDKN2A TERT
8 congenital mesoblastic nephroma 10.4 KIT NRAS
9 melanomatosis 10.3 CDKN2A NRAS
10 malignant skin fibrous histiocytoma 10.3 KIT NRAS
11 core binding factor acute myeloid leukemia 10.3 KIT NRAS
12 malignant dermis tumor 10.3 KIT NRAS
13 erdheim-chester disease 10.3 BRAF NRAS
14 meningeal melanomatosis 10.3 CDKN2A NRAS
15 meningeal melanocytoma 10.3 CDKN2A NRAS
16 adenoid basal cell carcinoma 10.3 CDKN2A KIT
17 amelanotic melanoma 10.3 BRAF KIT
18 ewing's family of tumors 10.2 CDKN2A KIT
19 cervical intraepithelial neoplasia 10.2 CDKN2A TERT
20 necrotizing sialometaplasia 10.2 CDKN2A KIT
21 spitz nevus 10.2 BRAF CDKN2A
22 mixed type thymoma 10.2 KIT PTEN
23 tongue cancer 10.2 CDKN2A TERT
24 fibrosarcoma of bone 10.2 CDKN2A KIT
25 gastrointestinal system benign neoplasm 10.2 CDKN2A KIT
26 sarcoma 10.1
27 skin squamous cell carcinoma 10.1 BRAF CDKN2A
28 langerhans cell histiocytosis 10.1 BRAF NRAS
29 neurofibroma 10.1 CDKN2A KIT
30 vulvar melanoma 10.0 KIT NRAS TERT
31 basal cell carcinoma 1 10.0
32 psoriatic arthritis 10.0
33 arthritis 10.0
34 nodular malignant melanoma 10.0
35 tinea pedis 10.0
36 phaeohyphomycosis 10.0
37 basal cell carcinoma 10.0
38 palmoplantar keratosis 10.0
39 laryngitis 10.0
40 clear cell sarcoma 10.0
41 tinea nigra 10.0
42 lichen planus 10.0
43 lentigo maligna melanoma 10.0
44 lichen planus pigmentosus 10.0
45 superficial spreading melanoma 10.0
46 giant cell glioblastoma 10.0 BRAF PTEN
47 spinal chordoma 9.9 MET TERT
48 undifferentiated pleomorphic sarcoma 9.9 KIT MET
49 small cell carcinoma 9.9 KIT PTEN
50 leishmaniasis 9.9

Graphical network of the top 20 diseases related to Acral Lentiginous Melanoma:



Diseases related to Acral Lentiginous Melanoma

Symptoms & Phenotypes for Acral Lentiginous Melanoma

UMLS symptoms related to Acral Lentiginous Melanoma:


macule

GenomeRNAi Phenotypes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased substrate adherent cell growth GR00193-A-1 9.23 KIT MET
2 Decreased substrate adherent cell growth GR00193-A-2 9.23 KIT
3 Decreased substrate adherent cell growth GR00193-A-3 9.23 BRAF MET
4 Decreased substrate adherent cell growth GR00193-A-4 9.23 BRAF KIT MET

MGI Mouse Phenotypes related to Acral Lentiginous Melanoma:

46 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.14 CDKN2A BRAF KIT TERT PTEN NRAS
2 digestive/alimentary MP:0005381 10.14 BRAF KIT CDKN2A TERT NRAS MET
3 endocrine/exocrine gland MP:0005379 10.12 BRAF KIT CDKN2A TERT NRAS MET
4 growth/size/body region MP:0005378 10.11 CDKN2A BRAF KIT TERT PTEN NRAS
5 behavior/neurological MP:0005386 10.09 CDKN2A BRAF PTEN KIT NRAS MET
6 homeostasis/metabolism MP:0005376 10.09 CDKN2A BRAF TERT PTEN KIT NRAS
7 cardiovascular system MP:0005385 10.08 CDKN2A BRAF PTEN KIT NRAS MET
8 immune system MP:0005387 10.08 CDKN2A BRAF KIT TERT NRAS MET
9 embryo MP:0005380 10.06 CDKN2A BRAF KIT NRAS MET PTEN
10 hematopoietic system MP:0005397 10.03 CDKN2A BRAF TERT PTEN KIT NRAS
11 mortality/aging MP:0010768 10.02 CDKN2A BRAF TERT PTEN KIT NRAS
12 neoplasm MP:0002006 9.98 BRAF KIT CDKN2A TERT NRAS MET
13 liver/biliary system MP:0005370 9.97 BRAF KIT CDKN2A NRAS MET PTEN
14 integument MP:0010771 9.92 CDKN2A BRAF PTEN KIT NRAS
15 nervous system MP:0003631 9.88 CDKN2A BRAF TERT PTEN KIT MET
16 muscle MP:0005369 9.85 CDKN2A BRAF PTEN KIT MET
17 normal MP:0002873 9.85 BRAF KIT TERT PTEN NRAS MET
18 limbs/digits/tail MP:0005371 9.81 PTEN KIT NRAS MET
19 pigmentation MP:0001186 9.72 BRAF KIT CDKN2A NRAS PTEN
20 reproductive system MP:0005389 9.65 CDKN2A BRAF TERT PTEN KIT
21 respiratory system MP:0005388 9.63 CDKN2A BRAF KIT TERT MET PTEN
22 skeleton MP:0005390 9.43 CDKN2A BRAF KIT TERT PTEN NRAS
23 vision/eye MP:0005391 9.1 CDKN2A BRAF KIT NRAS MET PTEN

Drugs & Therapeutics for Acral Lentiginous Melanoma

Drugs for Acral Lentiginous Melanoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
2
Pembrolizumab Approved Phase 2 1374853-91-4
3
Dasatinib Approved, Investigational Phase 2 302962-49-8 3062316
4
Cediranib Investigational Phase 2 288383-20-0 9933475
5
Maleic acid Experimental Phase 2 110-16-7 444266
6 Imatinib Mesylate Phase 2 220127-57-1 123596
7 Angiogenesis Inhibitors Phase 2
8 Angiogenesis Modulating Agents Phase 2
9 Protein Kinase Inhibitors Phase 2
10 tyrosine Nutraceutical Phase 2
11
Ganciclovir Approved, Investigational Phase 1 82410-32-0 3454
12 Ganciclovir triphosphate Phase 1
13 Nucleic Acid Synthesis Inhibitors Phase 1
14 Anti-Infective Agents Phase 1
15 Antiviral Agents Phase 1
16
nivolumab Approved 946414-94-4
17 Antibodies
18 Immunoglobulins
19 Antibodies, Monoclonal

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 A Phase Ⅲ Study to Investigate JS001 Versus Dacarbazine as the First Line Therapy for Unresectable or Metastatic Melanoma Recruiting NCT03430297 Phase 3 Dacarbazine 1000mg/m2 Q3W
2 A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread Completed NCT01395121 Phase 2 nilotinib
3 SU011248 in Patients With Metastatic Mucosal or Acral/Lentiginous Melanoma Completed NCT00577382 Phase 2 Sunitinib
4 Imatinib Mesylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery Completed NCT00470470 Phase 2 imatinib mesylate
5 AZD2171 in Treating Patients With Recurrent or Stage IV Melanoma Completed NCT00243061 Phase 2 cediranib maleate
6 Pembrolizumab in Advanced/Metastatic Acral Lentiginous Melanoma Recruiting NCT02875132 Phase 2 pembrolizumab
7 Dinaciclib in Treating Patients With Stage IV Melanoma Active, not recruiting NCT00937937 Phase 2 Dinaciclib
8 Dasatinib in Treating Patients With Locally Advanced or Metastatic Mucosal Melanoma, Acral Melanoma, or Vulvovaginal Melanoma That Cannot Be Removed By Surgery Active, not recruiting NCT00700882 Phase 2 dasatinib
9 Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With Stage IV Melanoma Terminated NCT01120275 Phase 2 gamma-secretase/Notch signalling pathway inhibitor RO4929097
10 Treatment With Dasatinib in Patients With Acral Lentiginous, Mucosal, or Chronic Sun-damaged Melanoma Terminated NCT01092728 Phase 2 Dasatinib
11 Gene Therapy and Ganciclovir in Treating Patients With Stage IV Melanoma Completed NCT00005057 Phase 1 ganciclovir
12 A Biomarker Study in Advanced Mucosal or Acral Lentiginous Melanoma Receiving Nivolumab in Combination With Ipilimumab Recruiting NCT02978443 Nivolumab;Ipilimumab
13 Study of Families With Melanoma Recruiting NCT00445783
14 French Clinical Datbase of Melanoma Patients (RIC-Mel) Recruiting NCT03315468

Search NIH Clinical Center for Acral Lentiginous Melanoma

Genetic Tests for Acral Lentiginous Melanoma

Anatomical Context for Acral Lentiginous Melanoma

MalaCards organs/tissues related to Acral Lentiginous Melanoma:

41
Skin, Lymph Node, Brain

Publications for Acral Lentiginous Melanoma

Articles related to Acral Lentiginous Melanoma:

(show top 50) (show all 140)
# Title Authors Year
1
High density of M2-macrophages in acral lentiginous melanoma compared to superficial spreading melanoma. ( 29415335 )
2018
2
Acral lentiginous melanoma. ( 29900875 )
2018
3
Acral Lentiginous Melanoma Is Associated with Certain Poor Prognostic Histopathological Factors but May Not be Correlated with Nodal Involvement, Recurrence, and a Worse Survival. ( 29860247 )
2018
4
Metastatic acral lentiginous melanoma in a tertiary referral center in Switzerland: a systematic analysis. ( 29847461 )
2018
5
Prognostic features for acral lentiginous melanoma. ( 29441559 )
2018
6
Clinical features and prognosis of Asian patients with acral lentiginous melanoma who have nodal nevi in their sentinel lymph node biopsy specimen. ( 29673774 )
2018
7
Acral lentiginous melanoma in the Turkish population and a new dermoscopic clue for the diagnosis. ( 29785333 )
2018
8
Diagnosis and Management of Acral Lentiginous Melanoma. ( 29951919 )
2018
9
Multiple Primary Acral Lentiginous Melanoma on the Feet Developing in Lesions of Nagashima-type Palmoplantar Keratoderma. ( 28224164 )
2017
10
Acral Lentiginous Melanoma, Indolent Subtype Diagnosed by En Bloc Excision: A Case Report. ( 28566910 )
2017
11
Acral lentiginous melanoma versus other melanoma: A single-center analysis in Japan. ( 28342269 )
2017
12
Tumor infiltrating lymphocytes in acral lentiginous melanoma: a study of a large cohort of cases from Latin America. ( 28577153 )
2017
13
Insulin-Like Growth Factor-II mRNA-Binding Protein 3 as a Novel Prognostic Biomarker for Acral Lentiginous Melanoma. ( 29048737 )
2017
14
Intracorneal Hematoma Showing Clinical and Dermoscopic Features of Acral Lentiginous Melanoma. ( 28567312 )
2017
15
The role of access to care in acral lentiginous melanoma survival. ( 28833024 )
2017
16
Prognostic factors and survival in acral lentiginous melanoma. ( 28432682 )
2017
17
Acral lentiginous melanoma - a skin cancer with unfavourable prognostic features. A study of the German Central Malignant Melanoma Registry (CMMR) in 2050 patients. ( 28707317 )
2017
18
Overexpression of Human Leukocyte Antigen-G and Interleukin 10 in acral lentiginous melanoma. ( 28587737 )
2017
19
Double Primary Acral Lentiginous Melanoma of both Soles. ( 28223769 )
2017
20
Acral lentiginous melanoma with dematiaceous fungal elements of Chaetomium globosum: A saprophytism or coexistence of superficial phaeohyphomycosis? ( 28836689 )
2017
21
Hidden acral lentiginous melanoma with cutaneous metastases masquerading as Kaposi's sarcoma in an HIV-positive Indian man. ( 26838298 )
2016
22
Survival of acral lentiginous melanoma in the National Cancer Institute of Colombia. ( 27518480 )
2016
23
Acral Lentiginous Melanoma. ( 26601870 )
2016
24
Histopathological diagnosis of acral lentiginous melanoma in early stages. ( 27601330 )
2016
25
Amelanotic acral lentiginous melanoma mimicking diabetic ulcer: a challenge to diagnose and treat. ( 26679765 )
2016
26
Molecular profiling, including TERT promoter mutations, of acral lentiginous melanomas. ( 26709572 )
2016
27
Acral lentiginous melanoma with multiple brain metastases in an Indian male. ( 27559525 )
2016
28
Insulin-Like Growth Factor II mRNA-Binding Protein 3 Expression Correlates with Poor Prognosis in Acral Lentiginous Melanoma. ( 26796627 )
2016
29
Rare cause of non-healing foot wound - acral lentiginous melanoma. Case Report. ( 26994380 )
2016
30
Reflectance confocal microscopy features of acral lentiginous melanoma: a comparative study with acral nevi. ( 26428577 )
2015
31
MAP Kinase Pathways: Molecular Roads to Primary Acral Lentiginous Melanoma. ( 26588333 )
2015
32
IMAGES IN CLINICAL MEDICINE. Acral Lentiginous Melanoma. ( 26535515 )
2015
33
Acral lentiginous melanoma of the foot misdiagnosed as a traumatic ulcer a cautionary case. ( 25815661 )
2015
34
The distribution pattern of HMB-45-positive cells is helpful for the diagnosis of early acral lentiginous melanoma in situ. ( 25773399 )
2015
35
Focal invasiveness in complete histological analyses of a large acral lentiginous melanoma. ( 26088594 )
2015
36
Reconstruction of large wounds using a combination of negative pressure wound therapy and punch grafting after excision of acral lentiginous melanoma on the foot. ( 26173565 )
2015
37
Screening for Acral Lentiginous Melanoma in Dark-Skinned Individuals. ( 26083954 )
2015
38
Acral lentiginous melanoma: who benefits from sentinel lymph node biopsy? ( 25455840 )
2015
39
Laryngeal metastases of acral lentiginous melanoma: Narrow band imaging. ( 25488159 )
2014
40
Acral lentiginous melanoma: indolent subtype with long radial growth phase. ( 24556899 )
2014
41
Acral Lentiginous Melanoma - Misdiagnosis, referral delay and 5 years specific survival according to site. ( 25027337 )
2014
42
Comparison of dermatoscopic images of acral lentiginous melanoma and acral melanocytic nevus occurring on body weight-bearing areas. ( 25396085 )
2014
43
TERT promoter mutation is uncommon in acral lentiginous melanoma. ( 24588324 )
2014
44
Indolent Subtype Acral Lentiginous Melanoma With Long Radial Growth Phase: A Dermatopathological Pitfall. ( 25072690 )
2014
45
Prognostic and Clinicopathologic Associations of BRAF Mutation in Primary Acral Lentiginous Melanoma in Korean Patients: A Preliminary Study. ( 24882974 )
2014
46
Recurrent acral lentiginous melanoma in situ suggesting the field cell theory. ( 25473243 )
2014
47
Two Spanish cases of Atypical Melanosis of the Foot, an early stage of Acral Lentiginous Melanoma in situ. ( 25323966 )
2014
48
TERT gene amplification is associated with poor outcome in acral lentiginous melanoma. ( 25219713 )
2014
49
Acral lentiginous melanoma treated with topical imiquimod cream: possible cooperation between drug and tumour cells. ( 25252087 )
2014
50
Psoriatic arthritis with acral lentiginous melanoma: role for methotrexate? ( 24249911 )
2013

Variations for Acral Lentiginous Melanoma

Cosmic variations for Acral Lentiginous Melanoma:

9
(show top 50) (show all 155)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM1166809 PTEN skin,acral,malignant melanoma,acral lentiginous c.333G>A p.W111* 10:87933092-87933092 22
2 COSM562 NRAS skin,acral,malignant melanoma,acral lentiginous c.34G>T p.G12C 1:114716127-114716127 22
3 COSM6503445 KIT skin,acral,malignant melanoma,acral lentiginous c.1658A>C p.Y553S 4:54727426-54727426 22
4 COSM1290 KIT skin,acral,malignant melanoma,acral lentiginous c.1727T>C p.L576P 4:54727495-54727495 22
5 COSM1257 KIT skin,acral,malignant melanoma,acral lentiginous c.1679T>A p.V560D 4:54727447-54727447 22
6 COSM1430154 KIT skin,acral,malignant melanoma,acral lentiginous c.1715A>G p.D572G 4:54727483-54727483 22
7 COSM6503446 KIT skin,acral,malignant melanoma,acral lentiginous c.1733A>G p.Y578C 4:54727501-54727501 22
8 COSM1255 KIT skin,acral,malignant melanoma,acral lentiginous c.1676T>C p.V559A 4:54727444-54727444 22
9 COSM18682 KIT skin,acral,malignant melanoma,acral lentiginous c.2468A>G p.Y823C 4:54733176-54733176 22
10 COSM235682 KIT skin,acral,malignant melanoma,acral lentiginous c.1965T>G p.N655K 4:54728096-54728096 22
11 COSM476 BRAF skin,acral,malignant melanoma,acral lentiginous c.1799T>A p.V600E 7:140753336-140753336 22
12 COSM460 BRAF skin,acral,malignant melanoma,acral lentiginous c.1406G>C p.G469A 7:140781602-140781602 22
13 COSM6951885 SETD2 skin,subungual,malignant melanoma,acral lentiginous c.3083C>G p.S1028C 3:47113999-47113999 16
14 COSM776 PIK3CA skin,subungual,malignant melanoma,acral lentiginous c.3140A>T p.H1047L 3:179234297-179234297 16
15 COSM6925493 PIK3C2G skin,subungual,malignant melanoma,acral lentiginous c.2381G>A p.W794* 12:18424039-18424039 16
16 COSM6945207 NOTCH1 skin,subungual,malignant melanoma,acral lentiginous c.5828C>T p.A1943V 9:136500658-136500658 16
17 COSM6925488 MUTYH skin,subungual,malignant melanoma,acral lentiginous c.1435C>A p.H479N 1:45331214-45331214 16
18 COSM6925489 MSH6 skin,subungual,malignant melanoma,acral lentiginous c.3731T>A p.L1244* 2:47806288-47806288 16
19 COSM6951887 ERBB3 skin,subungual,malignant melanoma,acral lentiginous c.3158G>C p.G1053A 12:56100202-56100202 16
20 COSM6951883 BARD1 skin,subungual,malignant melanoma,acral lentiginous c.1232C>T p.P411L 2:214780642-214780642 16
21 COSM6915212 AXL skin,subungual,malignant melanoma,acral lentiginous c.1934C>A p.A645E 19:41253633-41253633 16
22 COSM6925490 skin,subungual,malignant melanoma,acral lentiginous c.688C>T p.R230* 3:179201415-179201415 16
23 COSM6945206 skin,subungual,malignant melanoma,acral lentiginous c.5828C>T p.A1943V 9:136500658-136500658 16
24 COSM94987 skin,subungual,malignant melanoma,acral lentiginous c.3140A>T p.H1047L 3:179234297-179234297 16
25 COSM6951884 skin,subungual,malignant melanoma,acral lentiginous c.4592C>G p.S1531C 3:47113999-47113999 16
26 COSM6915211 skin,subungual,malignant melanoma,acral lentiginous c.1961C>A p.A654E 19:41253633-41253633 16
27 COSM6951886 skin,subungual,malignant melanoma,acral lentiginous c.3158G>C p.G1053A 12:56100202-56100202 16
28 COSM6951882 skin,subungual,malignant melanoma,acral lentiginous c.1232C>T p.P411L 2:214780642-214780642 16
29 COSM6925492 skin,subungual,malignant melanoma,acral lentiginous c.2504G>A p.W835* 12:18424039-18424039 16
30 COSM6925491 skin,subungual,malignant melanoma,acral lentiginous c.2381G>A p.W794* 12:18424039-18424039 16
31 COSM6939025 TP63 skin,NS,malignant melanoma,acral lentiginous c.1510C>G p.P504A 3:189889342-189889342 14
32 COSM29529 RB1 skin,NS,malignant melanoma,acral lentiginous c.1411C>T p.Q471* 13:48380074-48380074 14
33 COSM5413434 RAF1 skin,NS,malignant melanoma,acral lentiginous c.1472C>T p.T491I 3:12585745-12585745 14
34 COSM6936562 RAF1 skin,NS,malignant melanoma,acral lentiginous c.626T>C p.L209P 3:12606255-12606255 14
35 COSM6889946 PTPRT skin,NS,malignant melanoma,acral lentiginous c.2431G>A p.E811K 20:42199366-42199366 14
36 COSM6936567 PTPRS skin,NS,malignant melanoma,acral lentiginous c.3707T>C p.L1236P 19:5219997-5219997 14
37 COSM6943320 PTCH1 skin,NS,malignant melanoma,acral lentiginous c.344G>T p.G115V 9:95506457-95506457 14
38 COSM6921633 PRKN skin,NS,malignant melanoma,acral lentiginous c.1210G>A p.E404K 6:161360163-161360163 14
39 COSM6954881 POLE skin,NS,malignant melanoma,acral lentiginous c.3541A>G p.K1181E 12:132657177-132657177 14
40 COSM6921634 PMS2 skin,NS,malignant melanoma,acral lentiginous c.640G>A p.V214M 7:5999173-5999173 14
41 COSM6943848 PLCG2 skin,NS,malignant melanoma,acral lentiginous c.3094G>A p.G1032R 16:81937799-81937799 14
42 COSM228367 PIK3CB skin,NS,malignant melanoma,acral lentiginous c.3200A>T p.D1067V 3:138655402-138655402 14
43 COSM6922385 NTRK3 skin,NS,malignant melanoma,acral lentiginous c.1831G>A p.D611N 15:87933070-87933070 14
44 COSM6914116 NTRK2 skin,NS,malignant melanoma,acral lentiginous c.2219G>T p.S740I 9:85020252-85020252 14
45 COSM583 NRAS skin,NS,malignant melanoma,acral lentiginous c.182A>T p.Q61L 1:114713908-114713908 14
46 COSM565 NRAS skin,NS,malignant melanoma,acral lentiginous c.35G>C p.G12A 1:114716126-114716126 14
47 COSM3724522 NRAS skin,NS,malignant melanoma,acral lentiginous c.184G>C p.E62Q 1:114713906-114713906 14
48 COSM584 NRAS skin,NS,malignant melanoma,acral lentiginous c.182A>G p.Q61R 1:114713908-114713908 14
49 COSM586 NRAS skin,NS,malignant melanoma,acral lentiginous c.183A>C p.Q61H 1:114713907-114713907 14
50 COSM573 NRAS skin,NS,malignant melanoma,acral lentiginous c.38G>A p.G13D 1:114716123-114716123 14

Expression for Acral Lentiginous Melanoma

Search GEO for disease gene expression data for Acral Lentiginous Melanoma.

Pathways for Acral Lentiginous Melanoma

Pathways related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.56 BRAF CDKN2A KIT MET NRAS PTEN
2
Show member pathways
13.45 BRAF CDKN2A KIT MET NRAS PTEN
3
Show member pathways
13.02 BRAF KIT MET NRAS
4
Show member pathways
12.79 BRAF CDKN2A KIT NRAS
5
Show member pathways
12.75 BRAF KIT MET NRAS PTEN
6
Show member pathways
12.7 BRAF KIT MET NRAS
7
Show member pathways
12.68 BRAF MET NRAS PTEN
8
Show member pathways
12.67 BRAF MET NRAS PTEN
9
Show member pathways
12.63 KIT MET NRAS PTEN TERT
10 12.55 BRAF KIT MET NRAS
11
Show member pathways
12.51 BRAF KIT MET NRAS
12
Show member pathways
12.51 BRAF CDKN2A KIT NRAS PTEN
13
Show member pathways
12.5 KIT MET NRAS PTEN
14
Show member pathways
12.48 BRAF MET NRAS PTEN
15
Show member pathways
12.39 BRAF CDKN2A MET NRAS PTEN
16
Show member pathways
12.29 BRAF MET NRAS
17 12.27 CDKN2A MET NRAS PTEN
18 12.24 CDKN2A NRAS TERT
19
Show member pathways
12.24 BRAF MET NRAS PTEN
20 12.22 BRAF CDKN2A KIT MET NRAS PTEN
21
Show member pathways
12.19 BRAF NRAS PTEN
22 12.1 BRAF MET NRAS
23 11.98 CDKN2A NRAS PTEN
24 11.96 MET NRAS PTEN
25
Show member pathways
11.91 BRAF NRAS PTEN
26
Show member pathways
11.83 BRAF CDKN2A KIT MET NRAS PTEN
27 11.81 CDKN2A NRAS PTEN
28 11.74 BRAF CDKN2A PTEN
29
Show member pathways
11.62 BRAF KIT NRAS
30 11.6 BRAF CDKN2A NRAS PTEN
31 11.55 BRAF CDKN2A NRAS
32 11.45 BRAF NRAS
33 11.29 BRAF NRAS
34 11.27 KIT MET NRAS PTEN
35 11.19 BRAF NRAS
36 11.13 MET NRAS
37 11.12 NRAS PTEN

GO Terms for Acral Lentiginous Melanoma

Cellular components related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasmic side of plasma membrane GO:0009898 8.62 KIT PTEN

Biological processes related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 phosphorylation GO:0016310 9.81 BRAF CDKN2A KIT MET
2 positive regulation of gene expression GO:0010628 9.71 BRAF CDKN2A KIT PTEN
3 negative regulation of signal transduction GO:0009968 9.65 BRAF KIT MET
4 long-term synaptic potentiation GO:0060291 9.57 BRAF PTEN
5 visual learning GO:0008542 9.56 BRAF KIT
6 cellular response to nerve growth factor stimulus GO:1990090 9.55 BRAF PTEN
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.54 BRAF TERT
8 response to cadmium ion GO:0046686 9.52 KIT TERT
9 replicative senescence GO:0090399 9.49 CDKN2A TERT
10 somatic stem cell division GO:0048103 9.46 CDKN2A KIT
11 MAPK cascade GO:0000165 9.46 BRAF KIT MET NRAS
12 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.43 CDKN2A PTEN
13 regulation of protein stability GO:0031647 9.43 CDKN2A PTEN TERT
14 regulation of axon regeneration GO:0048679 9.37 BRAF PTEN
15 myeloid progenitor cell differentiation GO:0002318 9.32 BRAF KIT
16 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.26 BRAF KIT MET PTEN
17 negative regulation of apoptotic process GO:0043066 9.02 BRAF KIT MET PTEN TERT

Molecular functions related to Acral Lentiginous Melanoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.62 BRAF MET PTEN TERT
2 kinase activity GO:0016301 9.56 BRAF CDKN2A KIT MET
3 nucleotide binding GO:0000166 9.46 BRAF KIT MET NRAS
4 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.37 KIT MET
5 MAP kinase kinase kinase activity GO:0004709 9.13 BRAF KIT MET
6 mitogen-activated protein kinase kinase binding GO:0031434 8.8 BRAF KIT MET

Sources for Acral Lentiginous Melanoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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