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MCID: ACR005
MIFTS: 40

Acrodermatitis

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acrodermatitis

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MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 74 52 43 15 17 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2722
MeSH 43 D000169
NCIt 49 C84532
SNOMED-CT 67 8197001
UMLS 71 C0001197
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Summaries for Acrodermatitis

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Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to acrodermatitis enteropathica, zinc-deficiency type and psoriasis 14, pustular. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4), and among its related pathways/superpathways is Metal ion SLC transporters. The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Wikipedia : 74 Acrodermatitis /ac.ro.der.ma.ti.tis/ is a childhood form of dermatitis selectively affecting the hands... more...

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Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 313)
# Related Disease Score Top Affiliating Genes
1 acrodermatitis enteropathica, zinc-deficiency type 34.5 SLC39A4 SLC30A4 SLC30A2
2 psoriasis 14, pustular 34.0 IL36RN AP1S3
3 acrodermatitis chronica atrophicans 33.7 EPHA5 CFHR2 CD40LG
4 pustular psoriasis 33.0 IL36RN AP1S3
5 enteropathica 31.6 SLC39A4 SLC30A4 PLIN2 OTC ALB
6 pustulosis of palm and sole 31.3 TNFRSF1B IL36RN IL1RL2 CARD14 AP1S3
7 exanthem 30.6 TNFRSF1B CD40LG ALB
8 pustulosis palmaris et plantaris 30.2 IL36RN CD40LG AP1S3
9 impetigo herpetiformis 30.2 IL36RN IL1RL2 CARD14
10 dermatitis, atopic 29.8 CXCL9 CXCL10 CD40LG ALB
11 psoriasis 29.7 TNFRSF1B IL36RN CXCL9 CXCL10 CARD14 AP1S3
12 tenosynovitis 29.7 TNFRSF1B CD40LG
13 mycosis fungoides 29.7 TNFRSF1B CXCL9 CXCL10
14 bone inflammation disease 29.7 TNFRSF1B CD40LG ALB
15 geographic tongue 29.6 IL36RN IL1RL2 CARD14
16 periostitis 29.6 IL36RN IL1RL2 CARD14
17 chickenpox 29.6 TNFRSF1B CD40LG ALB
18 acquired immunodeficiency syndrome 29.5 TNFRSF1B CD40LG ALB
19 iridocyclitis 29.4 TNFRSF1B CD40LG
20 psoriatic arthritis 29.3 TNFRSF1B IL36RN CXCL10 CD40LG CARD14
21 skin disease 28.8 TNFRSF1B IL36RN CXCL9 CXCL10 CD40LG CARD14
22 gianotti crosti syndrome 12.4
23 zinc deficiency, transient neonatal 11.7
24 glucagonoma 11.5
25 psoriasis 1 11.2
26 lyme disease 10.6
27 alopecia 10.6
28 diarrhea 10.6
29 autosomal recessive disease 10.5
30 endotheliitis 10.5 CXCL9 CXCL10
31 sydenham chorea 10.5 CXCL9 CXCL10
32 blind loop syndrome 10.4 OTC ALB
33 opsoclonus-myoclonus syndrome 10.4 CXCL9 CXCL10
34 riedel's fibrosing thyroiditis 10.4 CD40LG ALB
35 systemic scleroderma 10.4
36 cork-handlers' disease 10.4 CD40LG ALB
37 fournier gangrene 10.4 CD40LG ALB
38 heterophyiasis 10.4 CD40LG ALB
39 dermatitis 10.4
40 non-secretory myeloma 10.3 CD40LG ALB
41 hepatitis b 10.3
42 meningovascular neurosyphilis 10.3 CD40LG ALB
43 splenic abscess 10.3 CD40LG ALB
44 anti-basement membrane glomerulonephritis 10.3 CFHR2 ALB
45 acalculous cholecystitis 10.3 CD40LG ALB
46 cystic fibrosis 10.3
47 gastrointestinal tuberculosis 10.3 CD40LG ALB
48 inflammatory and toxic neuropathy 10.3 CD40LG ALB
49 multifocal motor neuropathy 10.3 CXCL10 CD40LG
50 abdominal tuberculosis 10.3 CD40LG ALB

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis
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Symptoms & Phenotypes for Acrodermatitis

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MGI Mouse Phenotypes related to Acrodermatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.9 ALB CD40LG CXCL10 IL1RL2 IL36RN OTC
2 endocrine/exocrine gland MP:0005379 9.86 ALB CD40LG OTC PLIN2 SLC30A2 SLC30A4
3 immune system MP:0005387 9.7 ALB CARD14 CD40LG CXCL10 IL1RL2 IL36RN
4 integument MP:0010771 9.28 CARD14 CD40LG IL1RL2 IL36RN OTC PLIN2
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Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin 1 Receptor Antagonist Protein Phase 2
2 Antirheumatic Agents Phase 2
3
Zinc Approved, Investigational 7440-66-6 32051
4
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
5 Nutrients
6 Trace Elements
7 Micronutrients
8 Anti-Bacterial Agents
9 Antiprotozoal Agents
10 Antiparasitic Agents
11 Antimalarials
12 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Anakinra in Inflammatory Pustular Dermatoses: Evaluation of Therapeutic Efficacy and Validation of Pathogenic Mechanisms Completed NCT01794117 Phase 2 Anakinra
2 Genetic Study Explanatory Severe Zinc Deficiencies : Multicenter, Genetics, Controlled and Prospective Study Completed NCT02870166
3 Zinc Homeostasis and Kinetics in Children With CF Completed NCT00104494 Zinc acetate (20mg/d)
4 Inflammatory Proteins,Gene Polymorphisms, and Transcriptome Profiles in Patients With Chronic Atrophic Acrodermatitis Recruiting NCT02147262 doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
5 DIVERSITY OF BORRELIA SPECIES INVOLVED IN CUTANEOUS MANIFESTATIONS OF LYME BORRELIOSIS IN FRANCE Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

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Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

40
Skin, Breast, Bone, B Cells, Liver, T Cells, Lymph Node
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Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50) (show all 1741)
# Title Authors PMID Year
1
Efficacy and safety of TNF blockers and of ustekinumab in palmoplantar pustulosis and in acrodermatitis continua of Hallopeau. 61
32030802 2020
2
Effectiveness of brodalumab in acrodermatitis continua of Hallopeau: A case report. 61
31762153 2020
3
Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica. 61
31979155 2020
4
Genomics-based treatment in a patient with two overlapping heritable skin disorders: Epidermolysis bullosa and acrodermatitis enteropathica. 61
31930626 2020
5
Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature. 61
31987033 2020
6
Pustular Psoriasis: The Dawn of a New Era. 61
31971600 2020
7
[Lyme Borreliosis: Cutaneous and Neurologic Manifestations, Case Definitions and Therapy]. 61
31914465 2020
8
Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition. 61
31134587 2019
9
Novel nonsense mutation of the SLC39A4 gene in a family with atypical acrodermatitis enteropathica. 61
30980548 2019
10
Cutaneous manifestations of HAV, HBV, HCV. 61
31804053 2019
11
Image Gallery: Pemphigus vulgaris mimicking acrodermatitis continua of Hallopeau. 61
31742663 2019
12
Image Gallery: Acrodermatitis enteropathica: recurrent flares in adulthood. 61
31368114 2019
13
[Cutaneous manifestations of nutritional deficiencies]. 61
31746568 2019
14
Clinical Spectrum of Inherited Disorders of Metabolism. 61
31222555 2019
15
Treatment of Recalcitrant Acrodermatitis Continua of Hallopeau With Brodalumab 61
31603633 2019
16
Successful treatment of acrodermatitis continua of Hallopeau with apremilast. 61
31131903 2019
17
Serological diagnostics of Lyme borreliosis: comparison of assays in twelve clinical laboratories in Northern Europe. 61
31399914 2019
18
Concurrence of Acrodermatitis Enteropathica and Eczema Herpeticum in a Child with Atopic Dermatitis. 61
31607883 2019
19
Acrodermatitis Enteropathica Associated With Inflammatory Bowel Disease. 61
31750377 2019
20
Apremilast as a new treatment option for Acrodermatitis continua of Hallopeau. 61
30623424 2019
21
Acquired Acrodermatitis Enteropathica. 61
31461117 2019
22
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 61
31377720 2019
23
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
24
The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review. 61
30938189 2019
25
Treatment of acrodermatitis continua of hallopeau with ixekizumab. 61
31184530 2019
26
Nails as immune-privileged sites: A case of disabling Acrodermatitis continua of Hallopeau successfully treated with Apremilast. 61
31025500 2019
27
Hypereosinophilic syndrome masquerading as acrodermatitis enteropathica. 61
31172983 2019
28
Cutaneous paraneoplastic syndromes. 61
30736994 2019
29
Acrodermatitis enteropathica-like skin eruption with neonatal seizures in a child with biotinidase deficiency. 61
31323123 2019
30
Acquired acrodermatitis enteropathica due to zinc-depleted parenteral nutrition. 61
31124168 2019
31
Two cases of acrodermatitis continua suppurativa (Hallopeau's disease) treated with IL-17A inhibitors. 61
31241836 2019
32
Zwei Fälle von Acrodermatitis continua suppurativa (Morbus Hallopeau) unter Behandlung mit IL-17A-Hemmern. 61
31241845 2019
33
The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport. 61
31164399 2019
34
Zinc and skin: an update. 61
30873720 2019
35
Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells. 61
31157776 2019
36
Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature. 61
30969010 2019
37
50 Years Ago in The Journal of Pediatrics: Acrodermatitis Enteropathica: Defective Metabolism of Unsaturated Fatty Acids. 61
31027618 2019
38
Acrodermatitis continua of Hallopeau with dense infiltration of IgG4-positive cells in the lesional dermis. 61
30411319 2019
39
Asymetric red-blue hypertrophic hand and tenosynovitis due to acrodermatitis chronica atrophicans. 61
30239931 2019
40
Acrodermatitis dysmetabolica in phenylketonuria. 61
29884334 2019
41
Acrodermatitis Continua of Hallopeau with Psoriatic Arthritis. 61
30936225 2019
42
Quantifying the Oligomeric State of hZIP4 on the Surface of Cells. 61
30874431 2019
43
Biotin Is Required for the Zinc Homeostasis in the Skin. 61
31022908 2019
44
Clinical and genetic differences between pustular psoriasis subtypes. 61
30036598 2019
45
Acquired acrodermatitis enteropathica secondary to sleeve gastrectomy. 61
30688216 2019
46
Acrodermatitis continua of Hallopeau response to optimized biological therapy. 61
30865417 2019
47
[Infantile atypical hand-foot-mouth disease with features of eczema herpeticum and acrodermatitis]. 61
30652458 2019
48
Acrodermatitis continua of Hallopeau: clinical perspectives. 61
31497529 2019
49
Acrodermatitis continua of Hallopeau successfully treated with adalimumab: A case report. 61
30800311 2019
50
Case Report: Paradoxical acrodermatitis of Hallopeau-like eruption following anti-IL-17 therapy. 61
31448100 2019
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Variations for Acrodermatitis

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Expression for Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.
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Pathways for Acrodermatitis

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Pathways related to Acrodermatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metal ion SLC transporters 65
Show member pathways
 10.78 SLC39A4 SLC30A4 SLC30A2
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GO Terms for Acrodermatitis

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Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 EPHA5 CXCL9 CXCL10 CD40LG
2 extracellular region GO:0005576 9.23 TNFRSF1B PLIN2 IL36RN CXCL9 CXCL10 CFHR2

Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.77 TNFRSF1B IL36RN CXCL9 CXCL10 CD40LG
2 cytokine-mediated signaling pathway GO:0019221 9.73 TNFRSF1B IL36RN IL1RL2 CXCL10
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.63 TNFRSF1B CD40LG CARD14
4 neutrophil chemotaxis GO:0030593 9.58 IL36RN CXCL9 CXCL10
5 cellular response to lipopolysaccharide GO:0071222 9.56 TNFRSF1B IL36RN CXCL9 CXCL10
6 zinc ion transmembrane transport GO:0071577 9.48 SLC30A4 SLC30A2
7 response to zinc ion GO:0010043 9.33 SLC30A4 SLC30A2 OTC
8 regulation of sequestering of zinc ion GO:0061088 9.32 SLC30A4 SLC30A2
9 zinc ion transport GO:0006829 9.13 SLC39A4 SLC30A4 SLC30A2
10 inflammatory response GO:0006954 9.1 TNFRSF1B IL36RN IL1RL2 CXCL9 CXCL10 CD40LG

Molecular functions related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.46 IL36RN CXCL9 CXCL10 CD40LG
2 cation transmembrane transporter activity GO:0008324 9.26 SLC30A4 SLC30A2
3 CXCR3 chemokine receptor binding GO:0048248 8.96 CXCL9 CXCL10
4 zinc ion transmembrane transporter activity GO:0005385 8.8 SLC39A4 SLC30A4 SLC30A2
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Sources for Acrodermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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