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MCID: ACR005
MIFTS: 38

Acrodermatitis

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Acrodermatitis

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MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 74 20 44 15 17 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2722
MeSH 44 D000169
NCIt 50 C84532
SNOMED-CT 67 8197001
UMLS 71 C0001197
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Summaries for Acrodermatitis

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Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to acrodermatitis enteropathica, zinc-deficiency type and psoriasis 14, pustular. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4), and among its related pathways/superpathways are Metal ion SLC transporters and CXCR3-mediated signaling events. The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone marrow.

Wikipedia : 74 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the hands... more...

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Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 241)
# Related Disease Score Top Affiliating Genes
1 acrodermatitis enteropathica, zinc-deficiency type 32.2 SLC39A4 SLC30A4 SLC30A2 SLC30A1
2 psoriasis 14, pustular 32.2 IL36RN AP1S3
3 acrodermatitis chronica atrophicans 31.9 YBX3 SNORA1 RHOBTB2 CFHR2
4 pustular psoriasis 31.7 IL36RN AP1S3
5 pustulosis of palm and sole 31.7 IL36RN AP1S3
6 enteropathica 31.4 SLC39A4 SLC30A4 PLIN2 OTC ALB
7 skin disease 30.1 IL36RN CXCL9 CXCL10 ALB
8 pustulosis palmaris et plantaris 30.0 IL36RN AP1S3
9 gianotti crosti syndrome 11.5
10 zinc deficiency, transient neonatal 11.1
11 glucagonoma 10.9
12 psoriasis 1 10.9
13 alopecia 10.5
14 lyme disease 10.5
15 psoriasis 10.5
16 exanthem 10.4
17 diarrhea 10.4
18 autosomal recessive disease 10.4
19 dermatitis 10.3
20 endotheliitis 10.3 CXCL9 CXCL10
21 systemic scleroderma 10.3
22 opsoclonus-myoclonus syndrome 10.3 CXCL9 CXCL10
23 blind loop syndrome 10.3 OTC ALB
24 cystic fibrosis 10.2
25 hantavirus hemorrhagic fever with renal syndrome 10.2 CXCL10 ALB
26 mansonelliasis 10.2 CXCL9 CXCL10
27 impetigo 10.2
28 anti-basement membrane glomerulonephritis 10.2 CFHR2 ALB
29 pemphigus 10.2
30 reye syndrome 10.2 OTC ALB
31 maple syrup urine disease 10.2
32 toxic megacolon 10.2 RHOBTB2 ALB
33 psoriatic arthritis 10.2
34 impetigo herpetiformis 10.2
35 acute poststreptococcal glomerulonephritis 10.2 CFHR2 ALB
36 paracoccidioidomycosis 10.1 CXCL9 CXCL10 ALB
37 autoimmune disease of urogenital tract 10.1 CFHR2 ALB
38 keratosis 10.1
39 neuropathy 10.1
40 trypanosomiasis 10.1 CXCL9 CXCL10 ALB
41 hypersensitivity reaction type iv disease 10.1 CXCL10 CFHR2 ALB
42 hypersensitivity vasculitis 10.1 CFHR2 ALB
43 parasitic protozoa infectious disease 10.1 CXCL10 CFHR2 ALB
44 metal metabolism disorder 10.1 SLC39A4 SLC30A2 ALB
45 anorexia nervosa 10.1
46 paronychia 10.1
47 crohn's disease 10.1
48 primary bacterial infectious disease 10.1 CXCL10 CFHR2 ALB
49 interstitial lung disease 10.1 CXCL9 CXCL10 ALB
50 autoimmune disease of musculoskeletal system 10.1 CXCL10 CFHR2 ALB

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis
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Symptoms & Phenotypes for Acrodermatitis

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Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 2
3
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
4
Zinc Approved, Investigational 7440-66-6 32051
5 Anti-Infective Agents
6 Anti-Bacterial Agents
7 Antiparasitic Agents
8 Antiprotozoal Agents
9 Antimalarials

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Anakinra in Inflammatory Pustular Dermatoses: Evaluation of Therapeutic Efficacy and Validation of Pathogenic Mechanisms Completed NCT01794117 Phase 2 Anakinra
2 Inflammatory Proteins,Gene Polymorphisms, and Transcriptome Profiles in Patients With Chronic Atrophic Acrodermatitis Unknown status NCT02147262 doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
3 Genetic Study Explanatory Severe Zinc Deficiencies : Multicenter, Genetics, Controlled and Prospective Study Completed NCT02870166

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

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Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

40
Skin, Breast, Bone Marrow, Lymph Node, Small Intestine, Pancreas, Eye
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Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50) (show all 1795)
# Title Authors PMID Year
1
Acrodermatitis enteropathica in a 3-month-old boy. 61
33593949 2021
2
Acrodermatitis chronica atrophicans: clinical and microbiological characteristics of a cohort of 693 Slovenian patients. 61
33550695 2021
3
Treatment of acrodermatitis continua of hallopeau with ixekizumab. 61
31184530 2021
4
Classification of patients referred under suspicion of tick-borne diseases, Copenhagen, Denmark. 61
33126203 2021
5
Acquired Acrodermatitis Enteropathica. 61
33058784 2021
6
Acrodermatitis enteropathica-like eruption secondary to vitamin and amino acid deficiencies associated with pancreatic tumour. 61
33461793 2021
7
Dermatological Manifestations in Inflammatory Bowel Diseases. 61
33477990 2021
8
Acrodermatitis chronica atrophicans by Borrelia afzelii in an unusual geographical zone. 61
32533150 2020
9
Acrodermatitis continua Hallopeau successfully treated by risankizumab. 61
33368238 2020
10
Acrodermatitis Enteropathica: A Case Report. 61
33274070 2020
11
Kappa and lambda immunohistochemistry and in situ hybridization in the evaluation of atypical cutaneous lymphoid infiltrates. 61
32870521 2020
12
Brodalumab in the treatment of recalcitrant acrodermatitis continua of Hallopeau. 61
32920959 2020
13
Etanercept for pediatric acrodermatitis continua of Hallopeau: A case report and literature review. 61
32700773 2020
14
Squamous cell carcinoma arising on acrodermatitis continua of Hallopeau: clinical and noninvasive skin imaging features. 61
33241565 2020
15
Visual Dermatology: Acrodermatitis Continua of Hallopeau. 61
32731758 2020
16
Transient Symptomatic Zinc Deficiency Resembling Acrodermatitis Enteropathica in a Full-Term Breastfed Infant. 61
33025515 2020
17
Alopecia universalis-like hair loss in acrodermatitis enteropathica. 61
32428274 2020
18
A brief guide to pustular psoriasis for primary care providers. 61
33118424 2020
19
Efficacy and safety of TNF blockers and of ustekinumab in palmoplantar pustulosis and in acrodermatitis continua of Hallopeau. 61
32030802 2020
20
Clinical characteristics, genetics, comorbidities and treatment of palmoplantar pustulosis: A retrospective analysis of 66 cases in a single center in Taiwan. 61
32613680 2020
21
[Acrodermatitis continua of Hallopeau and psoriatic arthritis: A case report]. 61
32956338 2020
22
Three cases of IL36RN-associated pustulosis: An evolution of acrodermatitis continua of Hallopeau to generalized pustular psoriasis. 61
32769301 2020
23
Treatment of acrodermatitis continua of Hallopeau: A case series of 39 patients. 61
32632983 2020
24
Dermatological Manifestations in Pediatric Inflammatory Bowel Disease. 61
32842528 2020
25
Transient Symptomatic Zinc Deficiency in a Breastfed Infant Associated with Low Zinc Levels in Maternal Serum and Breast Milk Improving after Zinc Supplementation: An Uncommon Phenotype? 61
32832457 2020
26
Intramatricial methotrexate for treatment of resistant acrodermatitis continua of Hallopeau: An alternative in COVID-19. 61
32510719 2020
27
A novel homozygous mutation p.E88K in maternal SLC30A2 gene as a cause of transient neonatal zinc deficiency. 61
32278324 2020
28
Acrodermatitis Enteropathica as a Presentation of Cystic Fibrosis in an Infant. 61
32562404 2020
29
[Exanthem and painful leg in a 72-year-old female patient]. 61
32342114 2020
30
Presentation of Acrodermatitis Chronica Atrophicans Rashes on Lyme Disease Patients in Canada. 61
32512846 2020
31
Lyme borreliosis: diagnosis and management. 61
32457042 2020
32
Acrodermatitis Enteropathica. 61
32093930 2020
33
Acrodermatitis enteropathica: a hereditary form of zinc deficiency. 61
32442281 2020
34
Genomics-based treatment in a patient with two overlapping heritable skin disorders: Epidermolysis bullosa and acrodermatitis enteropathica. 61
31930626 2020
35
A case of pediatric acrodermatitis continua of Hallopeau successfully treated with adalimumab biosimilar. 61
32220123 2020
36
Image Gallery: Pemphigus vulgaris mimicking acrodermatitis continua of Hallopeau. 61
31742663 2020
37
Acrodermatitis enteropathica-like skin eruption with neonatal seizures in a child with biotinidase deficiency. 61
31323123 2020
38
Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature. 61
31987033 2020
39
Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica. 61
31979155 2020
40
Necrolytic Acral Erythema: Current Insights. 61
32308461 2020
41
Pustular Psoriasis: The Dawn of a New Era. 61
31971600 2020
42
[Lyme Borreliosis: Cutaneous and Neurologic Manifestations, Case Definitions and Therapy]. 61
31914465 2020
43
Effectiveness of brodalumab in acrodermatitis continua of Hallopeau: A case report. 61
31762153 2020
44
Novel nonsense mutation of the SLC39A4 gene in a family with atypical acrodermatitis enteropathica. 61
30980548 2019
45
Cutaneous manifestations of HAV, HBV, HCV. 61
31804053 2019
46
Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition. 61
31134587 2019
47
Image Gallery: Acrodermatitis enteropathica: recurrent flares in adulthood. 61
31368114 2019
48
[Cutaneous manifestations of nutritional deficiencies]. 61
31746568 2019
49
Serological diagnostics of Lyme borreliosis: comparison of assays in twelve clinical laboratories in Northern Europe. 61
31399914 2019
50
Successful treatment of acrodermatitis continua of Hallopeau with apremilast. 61
31131903 2019
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Variations for Acrodermatitis

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Expression for Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.
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Pathways for Acrodermatitis

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Pathways related to Acrodermatitis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Metal ion SLC transporters 65
Show member pathways
 11 SLC39A4 SLC39A11 SLC30A4 SLC30A2 SLC30A1
2
CXCR3-mediated signaling events 1
10.49 CXCL9 CXCL10
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GO Terms for Acrodermatitis

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Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.8 SLC39A4 SLC39A11 SLC30A4 SLC30A2 SLC30A1
2 transmembrane transport GO:0055085 9.77 SLC39A4 SLC39A11 SLC30A4 SLC30A2 SLC30A1
3 cellular response to lipopolysaccharide GO:0071222 9.61 IL36RN CXCL9 CXCL10
4 cation transport GO:0006812 9.5 SLC30A4 SLC30A2 SLC30A1
5 metal ion transport GO:0030001 9.49 SLC39A4 SLC39A11
6 cellular zinc ion homeostasis GO:0006882 9.48 SLC39A4 SLC30A1
7 positive regulation of release of sequestered calcium ion into cytosol GO:0051281 9.46 CXCL9 CXCL10
8 response to zinc ion GO:0010043 9.33 SLC30A4 SLC30A2 OTC
9 regulation of sequestering of zinc ion GO:0061088 9.26 SLC30A4 SLC30A2
10 zinc ion transmembrane transport GO:0071577 9.26 SLC39A11 SLC30A4 SLC30A2 SLC30A1
11 zinc ion transport GO:0006829 9.02 SLC39A4 SLC39A11 SLC30A4 SLC30A2 SLC30A1

Molecular functions related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion transmembrane transporter activity GO:0046873 9.32 SLC39A4 SLC39A11
2 CXCR chemokine receptor binding GO:0045236 9.26 CXCL9 CXCL10
3 CXCR3 chemokine receptor binding GO:0048248 9.16 CXCL9 CXCL10
4 cation transmembrane transporter activity GO:0008324 9.13 SLC30A4 SLC30A2 SLC30A1
5 zinc ion transmembrane transporter activity GO:0005385 9.02 SLC39A4 SLC39A11 SLC30A4 SLC30A2 SLC30A1
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Sources for Acrodermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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