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MCID: ACR005
MIFTS: 38

Acrodermatitis

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Acrodermatitis

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MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 74 52 43 15 17 71

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2722
MeSH 43 D000169
NCIt 49 C84532
UMLS 71 C0001197
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Summaries for Acrodermatitis

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Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to psoriasis 14, pustular and acrodermatitis chronica atrophicans. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and bone, and related phenotypes are immune system and integument

Wikipedia : 74 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the hands... more...

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Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 326)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 34.0 IL36RN AP1S3
2 acrodermatitis chronica atrophicans 33.3 SNORA1 EPHA5 CFHR2 CD40LG
3 pustular psoriasis 32.9 IL36RN AP1S3
4 enteropathica 31.6 SLC39A4 SLC30A4 PLIN2 OTC ALB
5 pustulosis of palm and sole 31.2 TNFRSF1B IL36RN IL1RL2 CARD14 AP1S3
6 exanthem 30.3 TNFRSF1B CD40LG ALB
7 pustulosis palmaris et plantaris 30.1 IL36RN CD40LG AP1S3
8 cryoglobulinemia 30.0 CXCL9 CXCL10 CD40LG
9 impetigo herpetiformis 29.9 IL36RN IL1RL2 CARD14 AP1S3
10 geographic tongue 29.8 IL36RN IL1RL2 CARD14
11 periostitis 29.8 IL36RN IL1RL2 CARD14
12 psoriasis 29.6 TNFRSF1B IL36RN CXCL9 CXCL10 CARD14 AP1S3
13 mycosis fungoides 29.5 TNFRSF1B CXCL9 CXCL10
14 pyoderma 29.4 TNFRSF1B IL36RN CD40LG
15 psoriatic arthritis 29.4 TNFRSF1B IL36RN CD40LG CARD14
16 tenosynovitis 29.3 TNFRSF1B CD40LG
17 bone inflammation disease 29.3 TNFRSF1B CD40LG ALB
18 chickenpox 29.2 TNFRSF1B CD40LG ALB
19 acquired immunodeficiency syndrome 29.2 TNFRSF1B CD40LG ALB
20 iridocyclitis 29.1 TNFRSF1B CD40LG
21 skin disease 28.6 TNFRSF1B IL36RN CXCL9 CXCL10 CD40LG CARD14
22 acrodermatitis enteropathica, zinc-deficiency type 12.9
23 gianotti crosti syndrome 12.4
24 zinc deficiency, transient neonatal 11.7
25 glucagonoma 11.5
26 psoriasis 1 11.2
27 lyme disease 10.6
28 alopecia 10.6
29 diarrhea 10.6
30 autosomal recessive disease 10.5
31 endotheliitis 10.5 CXCL9 CXCL10
32 sydenham chorea 10.4 CXCL9 CXCL10
33 opsoclonus-myoclonus syndrome 10.4 CXCL9 CXCL10
34 blind loop syndrome 10.4 OTC ALB
35 systemic scleroderma 10.4
36 dermatitis 10.4
37 anti-basement membrane glomerulonephritis 10.4 CFHR2 ALB
38 cystic fibrosis 10.3
39 hepatitis b 10.3
40 cork-handlers' disease 10.3 CD40LG ALB
41 maple syrup urine disease 10.3
42 impetigo 10.3
43 fournier gangrene 10.3 CD40LG ALB
44 heterophyiasis 10.3 CD40LG ALB
45 atrophic glossitis 10.3 IL36RN IL1RL2
46 non-secretory myeloma 10.3 CD40LG ALB
47 pemphigus 10.3
48 splenic abscess 10.2 CD40LG ALB
49 meningovascular neurosyphilis 10.2 CD40LG ALB
50 acalculous cholecystitis 10.2 CD40LG ALB

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis
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Symptoms & Phenotypes for Acrodermatitis

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MGI Mouse Phenotypes related to Acrodermatitis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.65 ALB CARD14 CD40LG CXCL10 IL1RL2 IL36RN
2 integument MP:0010771 9.23 CARD14 CD40LG IL1RL2 IL36RN OTC PLIN2
Sources

Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin 1 Receptor Antagonist Protein Phase 2
2 Antirheumatic Agents Phase 2
3
Zinc Approved, Investigational 7440-66-6 32051
4
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
5 Antiparasitic Agents
6 Antiprotozoal Agents
7 Anti-Bacterial Agents
8 Anti-Infective Agents
9 Antimalarials

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Anakinra in Inflammatory Pustular Dermatoses: Evaluation of Therapeutic Efficacy and Validation of Pathogenic Mechanisms Completed NCT01794117 Phase 2 Anakinra
2 Genetic Study Explanatory Severe Zinc Deficiencies : Multicenter, Genetics, Controlled and Prospective Study Completed NCT02870166
3 Zinc Homeostasis and Kinetics in Children With CF Completed NCT00104494 Zinc acetate (20mg/d)
4 Inflammatory Proteins,Gene Polymorphisms, and Transcriptome Profiles in Patients With Chronic Atrophic Acrodermatitis Recruiting NCT02147262 doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
5 DIVERSITY OF BORRELIA SPECIES INVOLVED IN CUTANEOUS MANIFESTATIONS OF LYME BORRELIOSIS IN FRANCE Recruiting NCT00576082
6 International Rare And Severe Psoriasis Expert Network (IRASPEN) - A Prospective Registry With Genotype-Phenotype Correlation Not yet recruiting NCT04359394

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

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Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

40
Skin, Breast, Bone, Liver, Lymph Node, B Cells, Testes
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Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50) (show all 1753)
# Title Authors PMID Year
1
Acrodermatitis Enteropathica as a Presentation of Cystic Fibrosis in an Infant. 61
32562404 2020
2
[Exanthem and painful leg in a 72-year-old female patient]. 61
32342114 2020
3
A novel homozygous mutation p.E88K in maternal SLC30A2 gene as a cause of transient neonatal zinc deficiency. 61
32278324 2020
4
Presentation of Acrodermatitis Chronica Atrophicans Rashes on Lyme Disease Patients in Canada. 61
32512846 2020
5
Acrodermatitis chronica atrophicans by Borrelia afzelii in an unusual geographical zone. 61
32533150 2020
6
Intramatricial methotrexate for treatment of resistant acrodermatitis continua of Hallopeau: an alterative in Covid-19. 61
32510719 2020
7
Genomics-based treatment in a patient with two overlapping heritable skin disorders: Epidermolysis bullosa and acrodermatitis enteropathica. 61
31930626 2020
8
Acrodermatitis Enteropathica. 61
32093930 2020
9
Lyme borreliosis: diagnosis and management. 61
32457042 2020
10
Alopecia universalis-like hair loss in acrodermatitis enteropathica. 61
32428274 2020
11
Acrodermatitis enteropathica: a hereditary form of zinc deficiency. 61
32442281 2020
12
A case of pediatric acrodermatitis continua of Hallopeau successfully treated with adalimumab biosimilar. 61
32220123 2020
13
Image Gallery: Pemphigus vulgaris mimicking acrodermatitis continua of Hallopeau. 61
31742663 2020
14
Acrodermatitis enteropathica-like skin eruption with neonatal seizures in a child with biotinidase deficiency. 61
31323123 2020
15
Efficacy and safety of TNF blockers and of ustekinumab in palmoplantar pustulosis and in acrodermatitis continua of Hallopeau. 61
32030802 2020
16
Elucidating the H+ Coupled Zn2+ Transport Mechanism of ZIP4; Implications in Acrodermatitis Enteropathica. 61
31979155 2020
17
Analysis of the relationship between the mutation site of the SLC39A4 gene and acrodermatitis enteropathica by reporting a rare Chinese twin: a case report and review of the literature. 61
31987033 2020
18
Necrolytic Acral Erythema: Current Insights. 61
32308461 2020
19
Pustular Psoriasis: The Dawn of a New Era. 61
31971600 2020
20
[Lyme Borreliosis: Cutaneous and Neurologic Manifestations, Case Definitions and Therapy]. 61
31914465 2020
21
Effectiveness of brodalumab in acrodermatitis continua of Hallopeau: A case report. 61
31762153 2020
22
Novel nonsense mutation of the SLC39A4 gene in a family with atypical acrodermatitis enteropathica. 61
30980548 2019
23
Cutaneous manifestations of HAV, HBV, HCV. 61
31804053 2019
24
Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition. 61
31134587 2019
25
Image Gallery: Acrodermatitis enteropathica: recurrent flares in adulthood. 61
31368114 2019
26
[Cutaneous manifestations of nutritional deficiencies]. 61
31746568 2019
27
Serological diagnostics of Lyme borreliosis: comparison of assays in twelve clinical laboratories in Northern Europe. 61
31399914 2019
28
Clinical Spectrum of Inherited Disorders of Metabolism. 61
31222555 2019
29
Successful treatment of acrodermatitis continua of Hallopeau with apremilast. 61
31131903 2019
30
Treatment of Recalcitrant Acrodermatitis Continua of Hallopeau With Brodalumab 61
31603633 2019
31
Concurrence of Acrodermatitis Enteropathica and Eczema Herpeticum in a Child with Atopic Dermatitis. 61
31607883 2019
32
Acrodermatitis Enteropathica Associated With Inflammatory Bowel Disease. 61
31750377 2019
33
Acquired Acrodermatitis Enteropathica. 61
31461117 2019
34
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 61
31377720 2019
35
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 61
31097370 2019
36
Apremilast as a new treatment option for Acrodermatitis continua of Hallopeau. 61
30623424 2019
37
Nails as immune-privileged sites: A case of disabling Acrodermatitis continua of Hallopeau successfully treated with Apremilast. 61
31025500 2019
38
Cutaneous paraneoplastic syndromes. 61
30736994 2019
39
Acquired acrodermatitis enteropathica due to zinc-depleted parenteral nutrition. 61
31124168 2019
40
Hypereosinophilic syndrome masquerading as acrodermatitis enteropathica. 61
31172983 2019
41
The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review. 61
30938189 2019
42
Treatment of acrodermatitis continua of hallopeau with ixekizumab. 61
31184530 2019
43
The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport. 61
31164399 2019
44
Zinc and skin: an update. 61
30873720 2019
45
Zwei Fälle von Acrodermatitis continua suppurativa (Morbus Hallopeau) unter Behandlung mit IL-17A-Hemmern. 61
31241845 2019
46
Two cases of acrodermatitis continua suppurativa (Hallopeau's disease) treated with IL-17A inhibitors. 61
31241836 2019
47
Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells. 61
31157776 2019
48
Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature. 61
30969010 2019
49
50 Years Ago in The Journal of Pediatrics: Acrodermatitis Enteropathica: Defective Metabolism of Unsaturated Fatty Acids. 61
31027618 2019
50
Asymetric red-blue hypertrophic hand and tenosynovitis due to acrodermatitis chronica atrophicans. 61
30239931 2019
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Variations for Acrodermatitis

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Expression for Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.
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Pathways for Acrodermatitis

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GO Terms for Acrodermatitis

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Cellular components related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.26 EPHA5 CXCL9 CXCL10 CD40LG
2 extracellular region GO:0005576 9.23 TNFRSF1B PLIN2 IL36RN CXCL9 CXCL10 CFHR2

Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.56 TNFRSF1B IL36RN IL1RL2 CXCL10
2 immune response GO:0006955 9.55 TNFRSF1B IL36RN CXCL9 CXCL10 CD40LG
3 tumor necrosis factor-mediated signaling pathway GO:0033209 9.5 TNFRSF1B CD40LG CARD14
4 leukocyte chemotaxis GO:0030595 9.37 CXCL9 CXCL10
5 cellular response to lipopolysaccharide GO:0071222 9.26 TNFRSF1B IL36RN CXCL9 CXCL10
6 inflammatory response GO:0006954 9.1 TNFRSF1B IL36RN IL1RL2 CXCL9 CXCL10 CD40LG

Molecular functions related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion transmembrane transporter activity GO:0005385 9.26 SLC39A4 SLC30A4
2 cytokine activity GO:0005125 9.26 IL36RN CXCL9 CXCL10 CD40LG
3 CXCR chemokine receptor binding GO:0045236 9.16 CXCL9 CXCL10
4 CXCR3 chemokine receptor binding GO:0048248 8.62 CXCL9 CXCL10
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Sources for Acrodermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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