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MCID: ACR005
MIFTS: 35

Acrodermatitis

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Acrodermatitis

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MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 75 53 44 15 17 72

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2722
MeSH 44 D000169
NCIt 50 C84532
SNOMED-CT 68 8197001
UMLS 72 C0001197
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Summaries for Acrodermatitis

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Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to psoriasis 14, pustular and pustulosis of palm and sole. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 75 Acrodermatitis /ac.ro.der.ma.ti.tis/ is a childhood form of dermatitis selectively affecting the hands... more...

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Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 33.5 IL36RN AP1S3
2 pustulosis of palm and sole 32.5 IL36RN AP1S3
3 pustular psoriasis 32.4 IL36RN AP1S3
4 enteropathica 30.1 SLC39A4 PLIN2 OTC ALB
5 pustulosis palmaris et plantaris 30.1 IL36RN AP1S3
6 acrodermatitis enteropathica, zinc-deficiency type 12.9
7 acrodermatitis chronica atrophicans 12.8
8 gianotti crosti syndrome 12.4
9 zinc deficiency, transient neonatal 11.7
10 glucagonoma 11.5
11 psoriasis 1 11.2
12 psoriasis 10.7
13 lyme disease 10.6
14 alopecia 10.6
15 diarrhea 10.6
16 exanthem 10.5
17 autosomal recessive disease 10.5
18 systemic scleroderma 10.4
19 hepatitis b 10.3
20 dermatitis 10.3
21 cystic fibrosis 10.3
22 maple syrup urine disease 10.3
23 impetigo 10.3
24 skin disease 10.2
25 crohn's disease 10.2
26 pemphigus 10.2
27 anorexia nervosa 10.2
28 psoriatic arthritis 10.2
29 paronychia 10.2
30 keratosis 10.2
31 impetigo herpetiformis 10.2
32 neuropathy 10.2
33 australia antigen 10.1
34 hepatitis 10.1
35 localized scleroderma 10.1
36 alcohol dependence 10.1
37 celiac disease 1 10.1
38 propionic acidemia 10.1
39 hydrops, lactic acidosis, and sideroblastic anemia 10.1
40 lymphoma 10.1
41 nephrotic syndrome 10.1
42 polyneuropathy 10.1
43 methylmalonic acidemia 10.1
44 agammaglobulinemia 10.1
45 arthropathy 10.1
46 lichen sclerosus 10.1
47 lichen sclerosus et atrophicus 10.0
48 3-methylglutaconic aciduria, type iii 10.0
49 phenylketonuria 10.0
50 yemenite deaf-blind hypopigmentation syndrome 10.0

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis
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Symptoms & Phenotypes for Acrodermatitis

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MGI Mouse Phenotypes related to Acrodermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ALB CXCL10 IL36RN OTC PLIN2 SLC39A4
2 liver/biliary system MP:0005370 8.92 ALB OTC PLIN2 SLC39A4
Sources

Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin 1 Receptor Antagonist Protein Phase 2
2 Antirheumatic Agents Phase 2
3
Zinc Approved, Investigational 7440-66-6 32051
4
Doxycycline Approved, Investigational, Vet_approved 564-25-0 54671203
5 Nutrients
6 Micronutrients
7 Trace Elements
8 Anti-Bacterial Agents
9 Antiparasitic Agents
10 Antimalarials
11 Antiprotozoal Agents
12 Anti-Infective Agents

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 2 Study of Anakinra in Inflammatory Pustular Dermatoses: Evaluation of Therapeutic Efficacy and Validation of Pathogenic Mechanisms Recruiting NCT01794117 Phase 2 Anakinra
2 Genetic Study Explanatory Severe Zinc Deficiencies : Multicenter, Genetics, Controlled and Prospective Study Completed NCT02870166
3 Zinc Homeostasis and Kinetics in Children With CF Completed NCT00104494 Zinc acetate (20mg/d)
4 Inflammatory Proteins,Gene Polymorphisms, and Transcriptome Profiles in Patients With Chronic Atrophic Acrodermatitis Recruiting NCT02147262 doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
5 DIVERSITY OF BORRELIA SPECIES INVOLVED IN CUTANEOUS MANIFESTATIONS OF LYME BORRELIOSIS IN FRANCE Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

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Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

41
Skin, Breast, Liver, Bone, Lymph Node, B Cells, Testes
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Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50) (show all 1725)
# Title Authors PMID Year
1
Image Gallery: Acrodermatitis enteropathica: recurrent flares in adulthood. 38
31368114 2019
2
Combined zinc and vitamin B6 deficiency in a patient with diffuse red rash and angular cheilitis 6 years after Roux-en-Y gastric bypass. 38
31377720 2019
3
Lyme borreliosis and other tick-borne diseases. Guidelines from the French Scientific Societies (I): prevention, epidemiology, diagnosis. 38
31097370 2019
4
Serological diagnostics of Lyme borreliosis: comparison of assays in twelve clinical laboratories in Northern Europe. 38
31399914 2019
5
Apremilast as a new treatment option for Acrodermatitis continua of Hallopeau. 38
30623424 2019
6
Nails as immune-privileged sites: A case of disabling Acrodermatitis continua of Hallopeau successfully treated with Apremilast. 38
31025500 2019
7
Acquired acrodermatitis enteropathica due to zinc-depleted parenteral nutrition. 38
31124168 2019
8
Acrodermatitis enteropathica-like skin eruption with neonatal seizures in a child with biotinidase deficiency. 38
31323123 2019
9
Cutaneous paraneoplastic syndromes. 38
30736994 2019
10
Hypereosinophilic syndrome masquerading as acrodermatitis enteropathica. 38
31172983 2019
11
The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review. 38
30938189 2019
12
Treatment of acrodermatitis continua of hallopeau with ixekizumab. 38
31184530 2019
13
Zinc and skin: an update. 38
30873720 2019
14
The histidine-rich loop in the extracellular domain of ZIP4 binds zinc and plays a role in zinc transport. 38
31164399 2019
15
Two cases of acrodermatitis continua suppurativa (Hallopeau's disease) treated with IL-17A inhibitors. 38
31241836 2019
16
Zwei Fälle von Acrodermatitis continua suppurativa (Morbus Hallopeau) unter Behandlung mit IL-17A-Hemmern. 38
31241845 2019
17
Clinical Spectrum of Inherited Disorders of Metabolism. 38
31222555 2019
18
Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells. 38
31157776 2019
19
Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature. 38
30969010 2019
20
50 Years Ago in The Journal of Pediatrics: Acrodermatitis Enteropathica: Defective Metabolism of Unsaturated Fatty Acids. 38
31027618 2019
21
Gianotti-Crosti syndrome (papular acrodermatitis of childhood) in the era of a viral recrudescence and vaccine opposition. 38
31134587 2019
22
Successful treatment of acrodermatitis continua of Hallopeau with apremilast. 38
31131903 2019
23
Novel nonsense mutation of the SLC39A4 gene in a family with atypical acrodermatitis enteropathica. 38
30980548 2019
24
Acrodermatitis Continua of Hallopeau with Psoriatic Arthritis. 38
30936225 2019
25
Acrodermatitis dysmetabolica in phenylketonuria. 38
29884334 2019
26
Quantifying the Oligomeric State of hZIP4 on the Surface of Cells. 38
30874431 2019
27
Biotin Is Required for the Zinc Homeostasis in the Skin. 38
31022908 2019
28
Asymetric red-blue hypertrophic hand and tenosynovitis due to acrodermatitis chronica atrophicans. 38
30239931 2019
29
Acrodermatitis continua of Hallopeau with dense infiltration of IgG4-positive cells in the lesional dermis. 38
30411319 2019
30
Clinical and genetic differences between pustular psoriasis subtypes. 38
30036598 2019
31
Acquired acrodermatitis enteropathica secondary to sleeve gastrectomy. 38
30688216 2019
32
[Infantile atypical hand-foot-mouth disease with features of eczema herpeticum and acrodermatitis]. 38
30652458 2019
33
Acrodermatitis continua of Hallopeau response to optimized biological therapy. 38
30865417 2019
34
Outcomes of various types of therapy in patients with treatment-resistant acrodermatitis continua of Hallopeau. 38
31190732 2019
35
Acrodermatitis chronica atrophicans in children: Report on two cases and review of the literature. 38
30389325 2019
36
Crusted scabies mimicking an acrodermatitis continua of Hallopeau. 38
31303653 2019
37
Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica? 38
30669644 2019
38
Acrodermatitis continua of Hallopeau successfully treated with adalimumab: A case report. 38
30800311 2019
39
Acrodermatitis enteropathica: the need for sustained high dose zinc supplementation. 38
30677805 2018
40
Acrodermatitis Continua of Hallopeau. 38
30285064 2018
41
Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis. 38
30429707 2018
42
Generalized pustular psoriasis: a review and update on treatment. 38
29573491 2018
43
Acquired zinc deficiency in a renal transplant recipient with gastrointestinal tuberculosis responding promptly to oral correction. 38
30381519 2018
44
Acrodermatitis-Like Rash in Kawasaki Disease. 38
29628413 2018
45
Ixekizumab for acrodermatitis continua. 38
29927543 2018
46
Ixekizumab gegen die Acrodermatitis continua. 38
29989369 2018
47
Acrodermatitis dysmetabolica as a sign of methylmalonic aciduria decompensation. 38
29881561 2018
48
Acrodermatitis enteropathica from zinc-deficient total parenteral nutrition. 38
30063773 2018
49
Efficacy and safety of acitretin monotherapy in children with pustular psoriasis: results from 15 cases and a literature review. 38
29098909 2018
50
Autoinflammatory keratinization diseases: An emerging concept encompassing various inflammatory keratinization disorders of the skin. 38
29422292 2018
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Variations for Acrodermatitis

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Expression for Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.
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Pathways for Acrodermatitis

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GO Terms for Acrodermatitis

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Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil chemotaxis GO:0030593 8.62 IL36RN CXCL10
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Sources for Acrodermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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