MCID: ACR005
MIFTS: 35

Acrodermatitis

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Acrodermatitis

MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 77 54 45 15 17 74

Classifications:



External Ids:

Disease Ontology 12 DOID:2722
MeSH 45 D000169
NCIt 51 C84532
SNOMED-CT 69 8197001
UMLS 74 C0001197

Summaries for Acrodermatitis

Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to psoriasis 14, pustular and pustulosis of palm and sole. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 77 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the hands... more...

Related Diseases for Acrodermatitis

Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 33.3 AP1S3 IL36RN
2 pustulosis of palm and sole 32.4 AP1S3 IL36RN
3 enteropathica 30.6 ALB OTC PLIN2 SLC39A4
4 pustular psoriasis 30.5 AP1S3 IL36RN
5 pustulosis palmaris et plantaris 29.7 AP1S3 IL36RN
6 acrodermatitis enteropathica, zinc-deficiency type 12.8
7 acrodermatitis chronica atrophicans 12.7
8 gianotti crosti syndrome 12.2
9 zinc deficiency, transient neonatal 11.4
10 glucagonoma 11.4
11 psoriasis 1 11.1
12 psoriasis 10.4
13 hepatitis 10.3
14 lyme disease 10.3
15 cystic fibrosis 10.3
16 hepatitis b 10.3
17 arthritis 10.2
18 anorexia nervosa 10.1
19 dermatitis 10.1
20 neuropathy 10.1
21 australia antigen 10.1
22 maple syrup urine disease 10.1
23 diarrhea 10.1
24 localized scleroderma 10.1
25 pemphigus 10.1
26 achondroplasia 10.0
27 celiac disease 1 10.0
28 psoriatic arthritis 10.0
29 nephrotic syndrome 10.0
30 peripheral nervous system disease 10.0
31 acute pyelonephritis 10.0 ALB CXCL10
32 tick-borne encephalitis 10.0 ALB CXCL10
33 rabies 10.0 ALB CXCL10
34 primary bacterial infectious disease 10.0 ALB CXCL10
35 alcohol dependence 9.9
36 chromosome 2q35 duplication syndrome 9.9
37 3-methylglutaconic aciduria, type iii 9.9
38 kawasaki disease 9.9
39 acute lymphocytic leukemia 9.9
40 crohn's disease 9.9
41 leukemia 9.9
42 pemphigus foliaceus 9.9
43 lymphocytic leukemia 9.9
44 lactose intolerance 9.9
45 short bowel syndrome 9.9
46 sarcoma 9.9
47 agammaglobulinemia 9.9
48 acquired immunodeficiency syndrome 9.9
49 pemphigus vegetans 9.9
50 proteasome-associated autoinflammatory syndrome 1 9.9 ALB CXCL10

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis

Symptoms & Phenotypes for Acrodermatitis

MGI Mouse Phenotypes related to Acrodermatitis:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ALB CXCL10 IL36RN OTC PLIN2 SLC39A4
2 liver/biliary system MP:0005370 8.92 ALB OTC PLIN2 SLC39A4

Drugs & Therapeutics for Acrodermatitis

Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin 1 Receptor Antagonist Protein Phase 2
2 Antirheumatic Agents Phase 2
3
Zinc Approved, Investigational 7440-66-6 32051
4
Doxycycline Approved, Investigational, Vet_approved Not Applicable 564-25-0 54671203
5 Anti-Bacterial Agents Not Applicable
6 Antiparasitic Agents Not Applicable
7 Anti-Infective Agents Not Applicable
8 Antiprotozoal Agents Not Applicable
9 Antimalarials Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
2 Genetic Study of Severe Zinc Deficiencies Completed NCT02870166
3 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262 Not Applicable doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
4 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

Genetic Tests for Acrodermatitis

Anatomical Context for Acrodermatitis

MalaCards organs/tissues related to Acrodermatitis:

42
Skin, Breast, Liver, Bone, Lymph Node, Colon, Eye

Publications for Acrodermatitis

Articles related to Acrodermatitis:

(show top 50) (show all 728)
# Title Authors Year
1
Acrodermatitis dysmetabolica in phenylketonuria. ( 29884334 )
2019
2
Asymetric red-blue hypertrophic hand and tenosynovitis due to acrodermatitis chronica atrophicans. ( 30239931 )
2019
3
Acrodermatitis chronica atrophicans in children: Report on two cases and review of the literature. ( 30389325 )
2019
4
Apremilast as a new treatment option for Acrodermatitis continua of Hallopeau. ( 30623424 )
2019
5
Zn-DTSM, A Zinc Ionophore with Therapeutic Potential for Acrodermatitis Enteropathica? ( 30669644 )
2019
6
Acquired acrodermatitis enteropathica secondary to sleeve gastrectomy. ( 30688216 )
2019
7
Acrodermatitis continua of Hallopeau successfully treated with adalimumab: A case report. ( 30800311 )
2019
8
Acrodermatitis continua of Hallopeau response to optimized biological therapy. ( 30865417 )
2019
9
Acrodermatitis Continua of Hallopeau with Psoriatic Arthritis. ( 30936225 )
2019
10
The Use of Biologic Therapy in the Treatment of Acrodermatitis Continua of Hallopeau: A Review. ( 30938189 )
2019
11
Biologic therapy for acrodermatitis continua of Hallopeau: Successful treatment with secukinumab and review of the literature. ( 30969010 )
2019
12
Novel nonsense mutation of the SLC39A4 gene in a family with atypical acrodermatitis enteropathica. ( 30980548 )
2019
13
Nails as immune-privileged sites: a case of disabling Acrodermatitis continua of Hallopeau successfully treated with Apremilast. ( 31025500 )
2019
14
50 Years Ago in The Journal of Pediatrics: Acrodermatitis Enteropathica: Defective Metabolism of Unsaturated Fatty Acids. ( 31027618 )
2019
15
Acrodermatitis-Like Rash in Kawasaki Disease. ( 29628413 )
2018
16
Treatment of acrodermatitis continua of Hallopeau with ustekinumab as monotherapy after failure of anti-TNF agents. ( 29659137 )
2018
17
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. ( 29687071 )
2018
18
A case of acrodermatitis continua of Hallopeau (ACH) successfully treated with sulfasalazine. ( 29696745 )
2018
19
Behandlung der Acrodermatitis continua suppurativa Hallopeau mit Ustekinumab als Monotherapie nach Versagen von TNF-Antagonisten. ( 29750449 )
2018
20
Acrodermatitis dysmetabolica as a sign of methylmalonic aciduria decompensation. ( 29881561 )
2018
21
Ixekizumab for acrodermatitis continua. ( 29927543 )
2018
22
Ixekizumab gegen die Acrodermatitis continua. ( 29989369 )
2018
23
Acrodermatitis Enteropathica Presenting with Recurrent Diarrhea and Vomiting in an Infant Reluctant to Breastfeed, and a Peculiar Erythemato-Eczematous Eruption around the Oral and Anogenital Regions. ( 29989544 )
2018
24
Acrodermatitis enteropathica from zinc-deficient total parenteral nutrition. ( 30063773 )
2018
25
Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition. ( 30142747 )
2018
26
Whole Genome Sequencing in an Acrodermatitis Enteropathica Family from the Middle East. ( 30174688 )
2018
27
Acrodermatitis continua of Hallopeau successfully treated with secukinumab. ( 30246571 )
2018
28
Acrodermatitis Continua of Hallopeau. ( 30285064 )
2018
29
Acrodermatitis continua of Hallopeau with dense infiltration of IgG4-positive cells in the lesional dermis. ( 30411319 )
2018
30
Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis. ( 30429707 )
2018
31
Acrodermatitis enteropathica: the need for sustained high dose zinc supplementation. ( 30677805 )
2018
32
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. ( 28056538 )
2018
33
Refractory acrodermatitis continua of Hallopeau successfully treated with oral alitretinoin. ( 28432697 )
2018
34
Pemphigus vegetans with the manifestations of acrodermatitis continua: A rare variant. ( 29058326 )
2018
35
Correlation of Reflectance Confocal Microscopy and Dermatopathology Findings in a Case of Acrodermatitis Chronica Atrophicans. ( 29251638 )
2018
36
Acrodermatitis acidaemica. ( 29336047 )
2018
37
ACRODERMATITIS ENTEROPATHICA: CLINICAL MANIFESTATIONS AND PEDIATRIC DIAGNOSIS. ( 29412435 )
2018
38
MKLN1 splicing defect in dogs with lethal acrodermatitis. ( 29565995 )
2018
39
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation. ( 27231138 )
2017
40
Acrodermatitis caused by nutritional deficiency and metabolic disorders. ( 27938814 )
2017
41
An Acrodermatitis Enteropathica-Associated Zn Transporter, ZIP4, Regulates Human Epidermal Homeostasis. ( 27940220 )
2017
42
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. ( 28017623 )
2017
43
Secukinumab for Acrodermatitis Continua of Hallopeau. ( 28122071 )
2017
44
Novel Application of High-Dose-Rate Brachytherapy for Severe, Recalcitrant Acrodermatitis Continua of Hallopeau. ( 28122079 )
2017
45
Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents. ( 28139054 )
2017
46
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. ( 28188634 )
2017
47
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. ( 28340843 )
2017
48
Acrodermatitis of Hallopeau and erosive oral mucositis successfully treated with secukinumab. ( 28443313 )
2017
49
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. ( 28521835 )
2017
50
Zinc Responsive Acrodermatitis in Nephrotic Syndrome. ( 28584768 )
2017

Variations for Acrodermatitis

Expression for Acrodermatitis

Search GEO for disease gene expression data for Acrodermatitis.

Pathways for Acrodermatitis

GO Terms for Acrodermatitis

Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil chemotaxis GO:0030593 8.62 CXCL10 IL36RN

Sources for Acrodermatitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....