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MCID: ACR005
MIFTS: 36

Acrodermatitis

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Acrodermatitis

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MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 76 53 44 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2722
MeSH 44 D000169
NCIt 50 C84532
SNOMED-CT 68 8197001
UMLS 73 C0001197
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Summaries for Acrodermatitis

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Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to psoriasis 14, pustular and pustulosis of palm and sole. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). The drugs Interleukin 1 Receptor Antagonist Protein and Antirheumatic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 76 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the hands... more...

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Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 97)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 33.2 AP1S3 IL36RN
2 pustulosis of palm and sole 32.3 AP1S3 IL36RN
3 enteropathica 30.9 ALB OTC PLIN2 SLC39A4
4 pustular psoriasis 30.5 AP1S3 IL36RN
5 psoriasis 30.2 AP1S3 CXCL10 IL36RN
6 pustulosis palmaris et plantaris 29.6 AP1S3 IL36RN
7 acrodermatitis enteropathica, zinc-deficiency type 12.7
8 acrodermatitis chronica atrophicans 12.6
9 gianotti crosti syndrome 11.9
10 zinc deficiency, transient neonatal 11.4
11 psoriasis 1 11.1
12 hepatitis 10.3
13 cystic fibrosis 10.3
14 hepatitis b 10.3
15 arthritis 10.1
16 anorexia nervosa 10.1
17 lyme disease 10.1
18 dermatitis 10.1
19 neuropathy 10.1
20 viral infectious disease 10.1
21 australia antigen 10.1
22 maple syrup urine disease 10.1
23 diarrhea 10.1
24 pemphigus 10.1
25 acute pyelonephritis 10.0 ALB CXCL10
26 tick-borne encephalitis 10.0 ALB CXCL10
27 celiac disease 1 10.0
28 nephrotic syndrome 10.0
29 peripheral nervous system disease 10.0
30 rabies 10.0 ALB CXCL10
31 primary bacterial infectious disease 10.0 ALB CXCL10
32 3-methylglutaconic aciduria, type iii 9.9
33 psoriatic arthritis 9.9
34 kawasaki disease 9.9
35 acute lymphocytic leukemia 9.9
36 crohn's disease 9.9
37 leukemia 9.9
38 pemphigus foliaceus 9.9
39 lymphocytic leukemia 9.9
40 lactose intolerance 9.9
41 short bowel syndrome 9.9
42 sarcoma 9.9
43 nutritional deficiency disease 9.9
44 pemphigus vegetans 9.9
45 proteasome-associated autoinflammatory syndrome 1 9.9 ALB CXCL10
46 brain edema 9.9 ALB OTC
47 respiratory system disease 9.8 ALB CXCL10
48 chromosome 2q35 duplication syndrome 9.8
49 down syndrome 9.8
50 abetalipoproteinemia 9.8

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis
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Symptoms & Phenotypes for Acrodermatitis

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MGI Mouse Phenotypes related to Acrodermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ALB CXCL10 IL36RN OTC PLIN2 SLC39A4
2 liver/biliary system MP:0005370 8.92 ALB OTC PLIN2 SLC39A4
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Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Interleukin 1 Receptor Antagonist Protein Phase 2
2 Antirheumatic Agents Phase 2
3
Zinc Approved, Investigational 7440-66-6
4
Doxycycline Approved, Investigational, Vet_approved Not Applicable 564-25-0 54671203
5 Antiparasitic Agents Not Applicable
6 Antiprotozoal Agents Not Applicable
7 Anti-Bacterial Agents Not Applicable
8 Antimalarials Not Applicable
9 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
2 Genetic Study of Severe Zinc Deficiencies Completed NCT02870166
3 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262 Not Applicable doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
4 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

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Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

41
Skin, Breast, Liver, Bone, Lymph Node, Tongue, Brain
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Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50) (show all 719)
# Title Authors Year
1
Acrodermatitis chronica atrophicans in children: Report on two cases and review of the literature. ( 30389325 )
2019
2
Treatment of acrodermatitis continua of Hallopeau with ustekinumab as monotherapy after failure of anti-TNF agents. ( 29659137 )
2018
3
Acrodermatitis dysmetabolica as a sign of methylmalonic aciduria decompensation. ( 29881561 )
2018
4
Pemphigus vegetans with the manifestations of acrodermatitis continua: A rare variant. ( 29058326 )
2018
5
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. ( 29687071 )
2018
6
A case of acrodermatitis continua of Hallopeau (ACH) successfully treated with sulfasalazine. ( 29696745 )
2018
7
MKLN1 splicing defect in dogs with lethal acrodermatitis. ( 29565995 )
2018
8
Behandlung der Acrodermatitis continua suppurativa Hallopeau mit Ustekinumab als Monotherapie nach Versagen von TNF-Antagonisten. ( 29750449 )
2018
9
Ixekizumab for acrodermatitis continua. ( 29927543 )
2018
10
ACRODERMATITIS ENTEROPATHICA: CLINICAL MANIFESTATIONS AND PEDIATRIC DIAGNOSIS. ( 29412435 )
2018
11
Acrodermatitis acidaemica. ( 29336047 )
2018
12
Acrodermatitis-Like Rash in Kawasaki Disease. ( 29628413 )
2018
13
Acrodermatitis dysmetabolica in phenylketonuria. ( 29884334 )
2018
14
Ixekizumab gegen die Acrodermatitis continua. ( 29989369 )
2018
15
Acrodermatitis Enteropathica Presenting with Recurrent Diarrhea and Vomiting in an Infant Reluctant to Breastfeed, and a Peculiar Erythemato-Eczematous Eruption around the Oral and Anogenital Regions. ( 29989544 )
2018
16
Acrodermatitis enteropathica from zinc-deficient total parenteral nutrition. ( 30063773 )
2018
17
Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition. ( 30142747 )
2018
18
Whole Genome Sequencing in an Acrodermatitis Enteropathica Family from the Middle East. ( 30174688 )
2018
19
Asymetric red-blue hypertrophic hand and tenosynovitis due to acrodermatitis chronica atrophicans. ( 30239931 )
2018
20
Acrodermatitis continua of Hallopeau successfully treated with secukinumab. ( 30246571 )
2018
21
Acrodermatitis Continua of Hallopeau. ( 30285064 )
2018
22
Acrodermatitis continua of Hallopeau with dense infiltration of IgG4 -positive cells in the lesional dermis. ( 30411319 )
2018
23
Acrodermatitis chronica atrophicans: various faces of the late form of Lyme borreliosis. ( 30429707 )
2018
24
Acrodermatitis, Enteropathica ( 28722865 )
2017
25
Acrodermatitis of Hallopeau and erosive oral mucositis successfully treated with secukinumab. ( 28443313 )
2017
26
Diagnosis of acrodermatitis enteropathica in resource limited settings. ( 28768674 )
2017
27
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. ( 28521835 )
2017
28
Correlation of Reflectance Confocal Microscopy and Dermatopathology Findings in a Case of Acrodermatitis Chronica Atrophicans. ( 29251638 )
2017
29
Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents. ( 28139054 )
2017
30
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. ( 28340843 )
2017
31
Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report. ( 29422844 )
2017
32
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. ( 28188634 )
2017
33
Zinc Responsive Acrodermatitis in Nephrotic Syndrome. ( 28584768 )
2017
34
Refractory acrodermatitis continua of Hallopeau successfully treated with oral alitretinoin. ( 28432697 )
2017
35
Acquired Acrodermatitis Enteropathica: A Case Study. ( 29152424 )
2017
36
Acrodermatitis caused by nutritional deficiency and metabolic disorders. ( 27938814 )
2017
37
Acrodermatitis enteropathica in a patient with short bowel syndrome. ( 29232432 )
2017
38
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. ( 28056538 )
2017
39
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. ( 28017623 )
2017
40
Secukinumab for Acrodermatitis Continua of Hallopeau. ( 28122071 )
2017
41
Dermoscopy in facilitating the recognition of acrodermatitis continua of Hallopeau. ( 28734002 )
2017
42
Highly Resistant Acrodermatitis Continua of Hallopeau and Pustular Psoriasis. ( 29177142 )
2017
43
Novel Application of High-Dose-Rate Brachytherapy for Severe, Recalcitrant Acrodermatitis Continua of Hallopeau. ( 28122079 )
2017
44
Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition. ( 29469698 )
2017
45
Acrodermatitis, Papular (Gianotti Crosti Syndrome) ( 28722855 )
2017
46
Pustules of the fingers: acrodermatitis continua. ( 27026671 )
2016
47
Asymmetric red-bluish foot due to acrodermatitis chronica atrophicans. ( 27335369 )
2016
48
A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States. ( 27502263 )
2016
49
Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis. ( 26856809 )
2016
50
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. ( 27904292 )
2016
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Variations for Acrodermatitis

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Expression for Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.
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Pathways for Acrodermatitis

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GO Terms for Acrodermatitis

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Biological processes related to Acrodermatitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil chemotaxis GO:0030593 8.62 CXCL10 IL36RN
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Sources for Acrodermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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