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MCID: ACR005
MIFTS: 34

Acrodermatitis

Categories: Rare diseases, Skin diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Acrodermatitis

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MalaCards integrated aliases for Acrodermatitis:

Name: Acrodermatitis 12 76 53 44 15 73

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Skin diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:2722
MeSH 44 D000169
NCIt 50 C84532
SNOMED-CT 68 8197001
UMLS 73 C0001197
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Summaries for Acrodermatitis

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Disease Ontology : 12 A dermatitis that selectively affects the hands and feet.

MalaCards based summary : Acrodermatitis is related to psoriasis 14, pustular and pustular psoriasis. An important gene associated with Acrodermatitis is SLC39A4 (Solute Carrier Family 39 Member 4). The drugs Antirheumatic Agents and Interleukin 1 Receptor Antagonist Protein have been mentioned in the context of this disorder. Affiliated tissues include skin, breast and liver, and related phenotypes are homeostasis/metabolism and liver/biliary system

Wikipedia : 76 Acrodermatitis /ac·ro·der·ma·ti·tis/ is a childhood form of dermatitis selectively affecting the hands... more...

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Related Diseases for Acrodermatitis

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Diseases related to Acrodermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 90)
# Related Disease Score Top Affiliating Genes
1 psoriasis 14, pustular 33.0 AP1S3 IL36RN
2 pustular psoriasis 30.1 AP1S3 IL36RN
3 pustulosis palmaris et plantaris 29.3 AP1S3 IL36RN
4 enteropathica 29.2 ALB OTC PLIN2 SLC39A4
5 psoriasis 28.7 AP1S3 CXCL10 IL36RN
6 acrodermatitis enteropathica, zinc-deficiency type 12.6
7 acrodermatitis chronica atrophicans 12.5
8 gianotti crosti syndrome 12.0
9 pustulosis of palm and sole 11.3
10 zinc deficiency, transient neonatal 11.2
11 psoriasis 1 10.9
12 hepatitis 10.1
13 cystic fibrosis 10.1
14 hepatitis b 10.1
15 tick-borne encephalitis 10.0 ALB CXCL10
16 anorexia nervosa 10.0
17 arthritis 10.0
18 dermatitis 10.0
19 neuropathy 10.0
20 acute pyelonephritis 9.9 ALB CXCL10
21 australia antigen 9.9
22 maple syrup urine disease 9.9
23 lyme disease 9.9
24 celiac disease 1 9.8
25 nephrotic syndrome 9.8
26 diarrhea 9.8
27 peripheral nervous system disease 9.8
28 pemphigus 9.8
29 rabies 9.8 ALB CXCL10
30 3-methylglutaconic aciduria, type iii 9.8
31 aging 9.8
32 acute lymphocytic leukemia 9.8
33 crohn's disease 9.8
34 leukemia 9.8
35 mucositis 9.8
36 lactose intolerance 9.8
37 short bowel syndrome 9.8
38 squamous cell carcinoma 9.8
39 pancreatitis 9.8
40 depression 9.8
41 pemphigus vegetans 9.8
42 down syndrome 9.6
43 abetalipoproteinemia 9.6
44 enterocolitis 9.6
45 hartnup disorder 9.6
46 netherton syndrome 9.6
47 phenylketonuria 9.6
48 psoriasis 2 9.6
49 dermatitis, atopic 9.6
50 reflex sympathetic dystrophy 9.6

Graphical network of the top 20 diseases related to Acrodermatitis:



Diseases related to Acrodermatitis
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Symptoms & Phenotypes for Acrodermatitis

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MGI Mouse Phenotypes related to Acrodermatitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ALB CXCL10 IL36RN OTC PLIN2 SLC39A4
2 liver/biliary system MP:0005370 8.92 ALB OTC PLIN2 SLC39A4
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Drugs & Therapeutics for Acrodermatitis

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Drugs for Acrodermatitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antirheumatic Agents Phase 2
2 Interleukin 1 Receptor Antagonist Protein Phase 2
3
Zinc Approved, Investigational 7440-66-6 23994
4
Doxycycline Approved, Investigational, Vet_approved Not Applicable 564-25-0 54671203
5 Anti-Bacterial Agents Not Applicable
6 Anti-Infective Agents Not Applicable
7 Antimalarials Not Applicable
8 Antiparasitic Agents Not Applicable
9 Antiprotozoal Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Anakinra for Inflammatory Pustular Skin Diseases Recruiting NCT01794117 Phase 2 Anakinra
2 Genetic Study of Severe Zinc Deficiencies Completed NCT02870166
3 Laboratory Characteristics in Chronic Atrophic Acrodermatitis Recruiting NCT02147262 Not Applicable doxycycline orally, 100 mg, bid, 14 days;doxycycline orally, 100 mg, bid, 28 days
4 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis

Cochrane evidence based reviews: acrodermatitis

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Genetic Tests for Acrodermatitis

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Anatomical Context for Acrodermatitis

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MalaCards organs/tissues related to Acrodermatitis:

41
Skin, Breast, Liver, Bone, T Cells, Tongue, Lymph Node
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Publications for Acrodermatitis

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Articles related to Acrodermatitis:

(show top 50) (show all 632)
# Title Authors Year
1
Treatment of acrodermatitis continua of Hallopeau with ustekinumab as monotherapy after failure of anti-TNF agents. ( 29659137 )
2018
2
Acrodermatitis dysmetabolica as a sign of methylmalonic aciduria decompensation. ( 29881561 )
2018
3
Pemphigus vegetans with the manifestations of acrodermatitis continua: A rare variant. ( 29058326 )
2018
4
Acrodermatitis continua of Hallopeau and geographic tongue are variants of pustular psoriasis. ( 29687071 )
2018
5
A case of acrodermatitis continua of Hallopeau (ACH) successfully treated with sulfasalazine. ( 29696745 )
2018
6
MKLN1 splicing defect in dogs with lethal acrodermatitis. ( 29565995 )
2018
7
Behandlung der Acrodermatitis continua suppurativa Hallopeau mit Ustekinumab als Monotherapie nach Versagen von TNF-Antagonisten. ( 29750449 )
2018
8
Ixekizumab for acrodermatitis continua. ( 29927543 )
2018
9
ACRODERMATITIS ENTEROPATHICA: CLINICAL MANIFESTATIONS AND PEDIATRIC DIAGNOSIS. ( 29412435 )
2018
10
Acrodermatitis acidaemica. ( 29336047 )
2018
11
Acrodermatitis-Like Rash in Kawasaki Disease. ( 29628413 )
2018
12
Acrodermatitis dysmetabolica in phenylketonuria. ( 29884334 )
2018
13
Acrodermatitis, Enteropathica ( 28722865 )
2017
14
Acrodermatitis of Hallopeau and erosive oral mucositis successfully treated with secukinumab. ( 28443313 )
2017
15
Diagnosis of acrodermatitis enteropathica in resource limited settings. ( 28768674 )
2017
16
Adult autoimmune enteropathy presenting initially with acquired Acrodermatitis Enteropathica: a case report. ( 28521835 )
2017
17
Correlation of Reflectance Confocal Microscopy and Dermatopathology Findings in a Case of Acrodermatitis Chronica Atrophicans. ( 29251638 )
2017
18
Ustekinumab for the treatment of acrodermatitis continua of Hallopeau refractory to anti-TNF agents. ( 28139054 )
2017
19
Acquired Acrodermatitis Enteropathica Syndrome in a Kidney Transplant Receipt: A Case Report. ( 28340843 )
2017
20
Acrodermatitis Continua of Hallopeau with Bone Resorption in an 8-Year-Old Patient: A Case Report. ( 29422844 )
2017
21
First report of SLC39A4 mutation in acrodermatitis enteropathica family from the Middle East. ( 28188634 )
2017
22
Zinc Responsive Acrodermatitis in Nephrotic Syndrome. ( 28584768 )
2017
23
Refractory acrodermatitis continua of Hallopeau successfully treated with oral alitretinoin. ( 28432697 )
2017
24
Acquired Acrodermatitis Enteropathica: A Case Study. ( 29152424 )
2017
25
Acrodermatitis caused by nutritional deficiency and metabolic disorders. ( 27938814 )
2017
26
Acrodermatitis enteropathica in a patient with short bowel syndrome. ( 29232432 )
2017
27
Sustained Need for High-Dose Zinc Supplementation in Children With Acrodermatitis Enteropathica. ( 28056538 )
2017
28
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. ( 28017623 )
2017
29
Secukinumab for Acrodermatitis Continua of Hallopeau. ( 28122071 )
2017
30
Dermoscopy in facilitating the recognition of acrodermatitis continua of Hallopeau. ( 28734002 )
2017
31
Highly Resistant Acrodermatitis Continua of Hallopeau and Pustular Psoriasis. ( 29177142 )
2017
32
Novel Application of High-Dose-Rate Brachytherapy for Severe, Recalcitrant Acrodermatitis Continua of Hallopeau. ( 28122079 )
2017
33
Acquired bullous acrodermatitis enteropathica as a histologic mimic of pemphigus foliaceus in a patient on parenteral nutrition. ( 29469698 )
2017
34
Acrodermatitis, Papular (Gianotti Crosti Syndrome) ( 28722855 )
2017
35
Pustules of the fingers: acrodermatitis continua. ( 27026671 )
2016
36
Asymmetric red-bluish foot due to acrodermatitis chronica atrophicans. ( 27335369 )
2016
37
A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States. ( 27502263 )
2016
38
Acrodermatitis Dysmetabolica in a Child with Cystic Fibrosis. ( 26856809 )
2016
39
A Case of Acrodermatitis Continua Accompanying with Osteolysis and Atrophy of the Distal Phalanx That Evoluted into Generalized Pustular Psoriasis. ( 27904292 )
2016
40
Acrodermatitis Chronica Atrophicans. ( 26687575 )
2016
41
Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases. ( 26781226 )
2016
42
A Case of Acrodermatitis Continua of Hallopeau Following Chronic Pustular Cheilitis. ( 26920763 )
2016
43
An acrodermatitis enteropathica-associated Zn transporter, ZIP4, regulates human epidermal homeostasis. ( 27940220 )
2016
44
Acrodermatitis chronica atrophicans-probably an overlooked differential diagnosis for arthritis. ( 27818388 )
2016
45
Acrodermatitis Enteropathica: A Case Report. ( 27196457 )
2016
46
Acrodermatitis Continua of Hallopeau with Granuloma-like Vegetation, Osteolysis and IL36RN Mutation. ( 27231138 )
2016
47
Acrodermatitis dysmetabolica in an infant with maple syrup urine disease. ( 27334242 )
2016
48
Acrodermatitis enteropathica: A novel mutation of the SLC39A4 gene in a Turkish boy. ( 26916651 )
2016
49
Acrodermatitis enteropathica in a pair of twins. ( 28435477 )
2016
50
Severe acquired acrodermatitis enteropathica caused by anorexia nervosa. ( 26661624 )
2016
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Variations for Acrodermatitis

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Expression for Acrodermatitis

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Search GEO for disease gene expression data for Acrodermatitis.
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Pathways for Acrodermatitis

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GO Terms for Acrodermatitis

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Sources for Acrodermatitis

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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