MCID: ACR097
MIFTS: 29

Acrodermatitis Chronica Atrophicans

Categories: Skin diseases

Aliases & Classifications for Acrodermatitis Chronica Atrophicans

MalaCards integrated aliases for Acrodermatitis Chronica Atrophicans:

Name: Acrodermatitis Chronica Atrophicans 12 15
Acrodermatitis Atrophicans Chronica 55 73
Primary Diffuse Atrophy 12
Herxheimer Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:0060344
ICD9CM 35 701.8
SNOMED-CT 68 201079006 201088002
ICD10 33 L90.4

Summaries for Acrodermatitis Chronica Atrophicans

Disease Ontology : 12 An acrodermatitis characterized by a chronically progressive course, leading to widespread atrophy of the skin. It is a clinical manifestation of Lyme borreliosis.

MalaCards based summary : Acrodermatitis Chronica Atrophicans, also known as acrodermatitis atrophicans chronica, is related to acrodermatitis and lyme disease. An important gene associated with Acrodermatitis Chronica Atrophicans is CD40LG (CD40 Ligand), and among its related pathways/superpathways is EphB-EphrinB Signaling. Affiliated tissues include skin and bone, and related phenotype is Dynamic nuclei (hole, folded or small irregular).

Wikipedia : 76 Acrodermatitis chronica atrophicans (ACA) (also known as Herxheimer disease and primary diffuse atrophy)... more...

Related Diseases for Acrodermatitis Chronica Atrophicans

Diseases related to Acrodermatitis Chronica Atrophicans via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 17)
# Related Disease Score Top Affiliating Genes
1 acrodermatitis 11.1
2 lyme disease 10.4
3 neuropathy 10.4
4 arthritis 10.4
5 peripheral nervous system disease 10.4
6 aging 10.1
7 venous insufficiency 10.1
8 interstitial nephritis 10.1
9 squamous cell carcinoma 10.1
10 arthropathy 10.1
11 lichen sclerosus 10.1
12 spirochetes disease 10.1
13 fallopian tube disease 9.6 CD40LG OVGP1
14 salpingitis 9.5 CD40LG OVGP1
15 primary bacterial infectious disease 9.4 CD40LG EPHA5
16 inclusion conjunctivitis 9.4 CD40LG OVGP1
17 acute salpingitis 9.3 CD40LG OVGP1

Graphical network of the top 20 diseases related to Acrodermatitis Chronica Atrophicans:



Diseases related to Acrodermatitis Chronica Atrophicans

Symptoms & Phenotypes for Acrodermatitis Chronica Atrophicans

GenomeRNAi Phenotypes related to Acrodermatitis Chronica Atrophicans according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Dynamic nuclei (hole, folded or small irregular) GR00257-A-1 8.92 AFDN CD40LG EPHA5 OVGP1

Drugs & Therapeutics for Acrodermatitis Chronica Atrophicans

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Borrelia Species in Cutaneous Lyme Borreliosis Recruiting NCT00576082

Search NIH Clinical Center for Acrodermatitis Chronica Atrophicans

Genetic Tests for Acrodermatitis Chronica Atrophicans

Anatomical Context for Acrodermatitis Chronica Atrophicans

MalaCards organs/tissues related to Acrodermatitis Chronica Atrophicans:

41
Skin, Bone

Publications for Acrodermatitis Chronica Atrophicans

Articles related to Acrodermatitis Chronica Atrophicans:

(show top 50) (show all 78)
# Title Authors Year
1
Correlation of Reflectance Confocal Microscopy and Dermatopathology Findings in a Case of Acrodermatitis Chronica Atrophicans. ( 29251638 )
2017
2
Pathogenetic implications of the age at time of diagnosis and skin location for acrodermatitis chronica atrophicans. ( 28017623 )
2017
3
Asymmetric red-bluish foot due to acrodermatitis chronica atrophicans. ( 27335369 )
2016
4
A Souvenir From France: Acrodermatitis Chronica Atrophicans Presenting in the United States. ( 27502263 )
2016
5
Acrodermatitis Chronica Atrophicans. ( 26687575 )
2016
6
Expanding the clinicopathological spectrum of late cutaneous Lyme borreliosis (acrodermatitis chronica atrophicans [ACA]): A prospective study of 20 culture- and/or polymerase chain reaction (PCR)-documented cases. ( 26781226 )
2016
7
Acrodermatitis chronica atrophicans-probably an overlooked differential diagnosis for arthritis. ( 27818388 )
2016
8
Histopathology and immunophenotype of acrodermatitis chronica atrophicans correlated with ospA and ospC genotypes of Borrelia species. ( 26156537 )
2015
9
Fibrous nodules over the patella revealing acrodermatitis chronica atrophicans. ( 25048097 )
2014
10
Acrodermatitis chronica atrophicans of the face: a case report and a brief review of the literature. ( 25230062 )
2014
11
Acrodermatitis chronica atrophicans with pseudolymphomatous infiltrates. ( 23147352 )
2013
12
Re: Andres C, et al. Acrodermatitis chronica atrophicans in two children. Int J Dermatol 2010; 49: 180-183. ( 23067095 )
2012
13
Acrodermatitis chronica atrophicans. ( 21958583 )
2011
14
Isolation of Borrelia burgdorferi sensu lato from blood of adult patients with borrelial lymphocytoma, Lyme neuroborreliosis, Lyme arthritis and acrodermatitis chronica atrophicans. ( 21153429 )
2011
15
Acrodermatitis chronica atrophicans: a case report and review of the literature. ( 20540415 )
2010
16
Acrodermatitis chronica atrophicans in two children. ( 20465643 )
2010
17
Skin-coloured facial oedema as an initial manifestation of acrodermatitis chronica atrophicans. ( 18482035 )
2008
18
Metastatic squamous cell carcinoma of the ankle in long-standing untreated acrodermatitis chronica atrophicans. ( 18607109 )
2008
19
Pick-Herxheimer's acrodermatitis chronica atrophicans in an endemic area of Northern Italy. ( 17184277 )
2006
20
Acrodermatitis chronica atrophicans in a 15-year-old girl misdiagnosed as venous insufficiency for 6 years. ( 15928636 )
2005
21
Two unusual cases of diffuse acrodermatitis chronica atrophicans seronegative for Lyme borreliosis. ( 12783283 )
2003
22
Acrodermatitis chronica atrophicans affecting all four limbs in an 11-year-old girl. ( 12174117 )
2002
23
Peripheral neuropathy in acrodermatitis chronica atrophicans - effect of treatment. ( 12371917 )
2002
24
Isolation of Borrelia burgdorferi sensu lato from a fibrous nodule in a patient with acrodermatitis chronica atrophicans. ( 12422596 )
2002
25
Differential expression of cytokine mRNA in skin specimens from patients with erythema migrans or acrodermatitis chronica atrophicans. ( 11121150 )
2000
26
Clinical features and specific immunological response to Borrelia afzelii in patients with acrodermatitis chronica atrophicans. ( 17312680 )
1999
27
Joint and bone involvement in Dutch patients with Lyme borreliosis presenting with acrodermatitis chronica atrophicans. ( 10048289 )
1999
28
Jaccoud's arthropathy in acrodermatitis chronica atrophicans. ( 9566685 )
1998
29
Acrodermatitis chronica atrophicans: histopathologic findings and clinical correlations in 111 cases. ( 9602229 )
1998
30
Acrodermatitis chronica atrophicans and serologic confirmation of infection due to Borrelia afzelii and/or Borrelia garinii by immunoblot. ( 11864312 )
1998
31
Rheumatic manifestations related to acrodermatitis chronica atrophicans. A review of four cases. ( 9809360 )
1998
32
Identification of three species of Borrelia burgdorferi sensu lato (B. burgdorferi sensu stricto, B. garinii, and B. afzelii) among isolates from acrodermatitis chronica atrophicans lesions. ( 9506437 )
1998
33
Peripheral neuropathy in acrodermatitis chronica atrophicans - a late Borrelia manifestation. ( 9228267 )
1997
34
Long-term prognosis in patients treated for erythema chronicum migrans and acrodermatitis chronica atrophicans. ( 9006370 )
1997
35
Detection of Borrelia afzelii, Borrelia burgdorferi sensu stricto, Borrelia garinii and group VS116 by PCR in skin biopsies of patients with erythema migrans and acrodermatitis chronica atrophicans. ( 11864084 )
1997
36
Success and failure in the treatment of acrodermatitis chronica atrophicans. ( 8852478 )
1996
37
Etiology of the acrodermatitis chronica atrophicans lesion in Lyme disease. ( 8699080 )
1996
38
Acrodermatitis chronica atrophicans in an Italian child. ( 8800311 )
1996
39
Acrodermatitis chronica atrophicans in an 11-year-old girl. ( 8915157 )
1996
40
Lymphoproliferative responses to Borrelia burgdorferi in patients with erythema migrans, acrodermatitis chronica atrophicans, lymphadenosis benigna cutis, and morphea. ( 7778918 )
1995
41
Acrodermatitis chronica atrophicans: a light and electron microscopic study. ( 7751475 )
1995
42
Identification of Borrelia afzelii in a juxta-articular fibroid nodule from a human immunodeficiency virus-positive patient with acrodermatitis chronica atrophicans. ( 7503587 )
1995
43
Changes in Borrelia burgdorferi-specific serum IgG antibody levels in patients treated for acrodermatitis chronica atrophicans. ( 7701871 )
1994
44
Acrodermatitis chronica atrophicans: a case report and review of the literature. ( 7999602 )
1994
45
Detection of Borrelia burgdorferi sensu lato in lesional skin of patients with erythema migrans and acrodermatitis chronica atrophicans by ospA-specific PCR. ( 7883886 )
1994
46
Molecular subtyping of Borrelia burgdorferi in erythema migrans and acrodermatitis chronica atrophicans. ( 8027576 )
1994
47
Acrodermatitis chronica atrophicans in the United States: clinical and histopathologic features of six cases. ( 7956339 )
1994
48
Serological follow-up after treatment of Borrelia arthritis and acrodermatitis chronica atrophicans. ( 7939435 )
1994
49
Acrodermatitis chronica atrophicans involving the face. Evidence for Borrelia burgdorferi infection confirmed by DNA amplification. ( 7873838 )
1994
50
Histopathologic patterns of acrodermatitis chronica atrophicans. ( 8221520 )
1993

Variations for Acrodermatitis Chronica Atrophicans

Expression for Acrodermatitis Chronica Atrophicans

Search GEO for disease gene expression data for Acrodermatitis Chronica Atrophicans.

Pathways for Acrodermatitis Chronica Atrophicans

Pathways related to Acrodermatitis Chronica Atrophicans according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.01 AFDN EPHA5

GO Terms for Acrodermatitis Chronica Atrophicans

Cellular components related to Acrodermatitis Chronica Atrophicans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.96 CD40LG EPHA5
2 adherens junction GO:0005912 8.62 AFDN EPHA5

Biological processes related to Acrodermatitis Chronica Atrophicans according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of actin cytoskeleton organization GO:0032956 8.62 EPHA5 RHOBTB2

Sources for Acrodermatitis Chronica Atrophicans

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....