MCID: ACT245
MIFTS: 23

Acth-Dependent Cushing Syndrome

Categories: Endocrine diseases, Rare diseases, Reproductive diseases

Aliases & Classifications for Acth-Dependent Cushing Syndrome

MalaCards integrated aliases for Acth-Dependent Cushing Syndrome:

Name: Acth-Dependent Cushing Syndrome 58
Adrenocorticotropic Hormone-Dependent Cushing Syndrome 58
Corticotropin-Dependent Cushing Syndrome 58
Acth-Dependent Cs 58

Classifications:

Orphanet: 58  
Rare infertility disorders
Rare endocrine diseases


Summaries for Acth-Dependent Cushing Syndrome

MalaCards based summary : Acth-Dependent Cushing Syndrome, also known as adrenocorticotropic hormone-dependent cushing syndrome, is related to primary pigmented nodular adrenocortical disease and pituitary adenoma 4, acth-secreting. An important gene associated with Acth-Dependent Cushing Syndrome is USP8 (Ubiquitin Specific Peptidase 8). Affiliated tissues include pituitary, and related phenotypes are failure to thrive and muscle weakness

Related Diseases for Acth-Dependent Cushing Syndrome

Diseases related to Acth-Dependent Cushing Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 16)
# Related Disease Score Top Affiliating Genes
1 primary pigmented nodular adrenocortical disease 11.4
2 pituitary adenoma 4, acth-secreting 11.3
3 acth-independent macronodular adrenal hyperplasia 11.3
4 olfactory neuroblastoma 10.3
5 neuroblastoma 10.3
6 pituitary tumors 10.2
7 kaposi sarcoma 10.2
8 human herpesvirus 8 10.2
9 leptin deficiency or dysfunction 10.2
10 sarcoma 10.2
11 conn's syndrome 10.2
12 pituitary adenoma 10.2
13 spindle cell sarcoma 10.2
14 47,xyy 10.2
15 thyroiditis 10.1
16 bronchial adenomas/carcinoids childhood 10.1

Graphical network of the top 20 diseases related to Acth-Dependent Cushing Syndrome:



Diseases related to Acth-Dependent Cushing Syndrome

Symptoms & Phenotypes for Acth-Dependent Cushing Syndrome

Human phenotypes related to Acth-Dependent Cushing Syndrome:

58 31 (show all 22)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 failure to thrive 58 31 hallmark (90%) Very frequent (99-80%) HP:0001508
2 muscle weakness 58 31 hallmark (90%) Very frequent (99-80%) HP:0001324
3 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
4 striae distensae 58 31 hallmark (90%) Very frequent (99-80%) HP:0001065
5 bruising susceptibility 58 31 hallmark (90%) Very frequent (99-80%) HP:0000978
6 thin skin 58 31 hallmark (90%) Very frequent (99-80%) HP:0000963
7 pituitary adenoma 58 31 hallmark (90%) Very frequent (99-80%) HP:0002893
8 depressivity 58 31 frequent (33%) Frequent (79-30%) HP:0000716
9 diabetes mellitus 58 31 frequent (33%) Frequent (79-30%) HP:0000819
10 hypertension 58 31 frequent (33%) Frequent (79-30%) HP:0000822
11 hypokalemia 58 31 frequent (33%) Frequent (79-30%) HP:0002900
12 immunodeficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002721
13 acne 58 31 frequent (33%) Frequent (79-30%) HP:0001061
14 osteoporosis 58 31 frequent (33%) Frequent (79-30%) HP:0000939
15 anxiety 58 31 frequent (33%) Frequent (79-30%) HP:0000739
16 lipodystrophy 58 31 frequent (33%) Frequent (79-30%) HP:0009125
17 nephrolithiasis 58 31 frequent (33%) Frequent (79-30%) HP:0000787
18 generalized hirsutism 58 31 frequent (33%) Frequent (79-30%) HP:0002230
19 generalized hyperpigmentation 58 31 frequent (33%) Frequent (79-30%) HP:0007440
20 round face 58 31 frequent (33%) Frequent (79-30%) HP:0000311
21 infertility 58 31 frequent (33%) Frequent (79-30%) HP:0000789
22 menometrorrhagia 58 31 frequent (33%) Frequent (79-30%) HP:0400008

Drugs & Therapeutics for Acth-Dependent Cushing Syndrome

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prospective, Non-interventional Clinical Study of Biomarker Expression in Patients With ACTH-Dependent Cushing's Syndrome Before and After Surgery Completed NCT02922257

Search NIH Clinical Center for Acth-Dependent Cushing Syndrome

Genetic Tests for Acth-Dependent Cushing Syndrome

Anatomical Context for Acth-Dependent Cushing Syndrome

MalaCards organs/tissues related to Acth-Dependent Cushing Syndrome:

40
Pituitary

Publications for Acth-Dependent Cushing Syndrome

Articles related to Acth-Dependent Cushing Syndrome:

(show all 42)
# Title Authors PMID Year
1
Ectopic ACTH- and/or CRH-Producing Pheochromocytomas. 61
32710791 2021
2
To determine the efficacy of bilateral inferior petrosal sinus sampling in differentiating Cushing disease from ectopic Cushing syndrome. 61
33484548 2021
3
Pitfalls In Performing And Interpreting Inferior Petrosal Sinus Sampling: Personal Experience And Literature Review. 61
33421066 2021
4
Development and validation of a novel index for the differential diagnosis of corticotropin-dependent Cushing syndrome. 61
33502672 2021
5
Is it Time for a New Approach to the Differential Diagnosis of ACTH-Dependent Cushing Syndrome? 61
33022714 2020
6
Bilateral Adrenalectomy: Differences between Cushing Disease and Ectopic ACTH-Producing Tumors. 61
32388739 2020
7
Prospective Evaluation of Late-Night Salivary Cortisol and Cortisone by EIA and LC-MS/MS in Suspected Cushing Syndrome. 61
32935666 2020
8
Differential diagnostic value of bilateral inferior Petrosal sinus sampling (BIPSS) in ACTH-dependent Cushing syndrome: a systematic review and Meta-analysis. 61
32943040 2020
9
Percutaneous Bilateral Adrenal Radiofrequency Ablation in Severe Adrenocorticotropic Hormone-dependent Cushing Syndrome. 61
33094002 2020
10
68Ga-DOTATATE PET/CT of Ectopic Cushing Syndrome Due to Appendicular Carcinoid. 61
31524683 2019
11
Postoperative expression of Cushing disease in a young male: metamorphosis of silent corticotroph adenoma? 61
31671410 2019
12
Challenges in diagnosis of disease reported 100 years back: Cushing syndrome; recent advances. 61
31201401 2019
13
Value of fluorine-18-fluorodeoxyglucose PET/CT in localizing the primary lesion in adrenocorticotropic hormone-dependent Cushing syndrome. 61
30973841 2019
14
Adrenocorticotropic Hormone-Dependent Cushing Syndrome Caused by an Olfactory Neuroblastoma. 61
30728732 2019
15
Severe Cushing Syndrome Due to an ACTH-Producing Pheochromocytoma: A Case Presentation and Review of the Literature. 61
29942926 2018
16
Case-series of paraneoplastic Cushing syndrome in small-cell lung cancer. 61
29535866 2018
17
Case report of a bilateral adrenal myelolipoma associated with Cushing disease. 61
29384929 2017
18
Transient pituitary ACTH-dependent Cushing syndrome caused by an immune checkpoint inhibitor combination. 61
29036015 2017
19
A Case of Pulmonary Carcinoid Tumor with a Superimposed Aspergilloma Presenting As a Covert Ectopic Adrenocorticotropic Hormone Syndrome. 61
28642733 2017
20
VENOUS SAMPLING FOR CUSHING DISEASE: COMPARISON OF INTERNAL JUGULAR VEIN AND INFERIOR PETROSAL SINUS SAMPLING. 61
27214296 2016
21
The first description of metyrapone use in severe Cushing Syndrome due to ectopic ACTH secretion in an infant with immature sacrococcygeal teratoma. Case Report. 61
26859587 2015
22
A Case of Ectopic Adrenocorticotropic Hormone Syndrome in Small Cell Lung Cancer. 61
26508941 2015
23
PITUITARY MRI FINDINGS IN PATIENTS WITH PITUITARY AND ECTOPIC ACTH-DEPENDENT CUSHING SYNDROME: DOES A 6-MM PITUITARY TUMOR SIZE CUT-OFF VALUE EXCLUDE ECTOPIC ACTH SYNDROME? 61
26121435 2015
24
Cushing syndrome: update on testing. 61
25732641 2015
25
Ectopic ACTH-secreting pituitary adenoma of the sphenoid sinus: case report of endoscopic endonasal resection and systematic review of the literature. 61
25639312 2015
26
A pediatric patient with Cushing syndrome caused by ectopic ACTH syndrome and concomitant pituitary incidentalomas. 61
23945121 2014
27
Cushing disease revealed by bilateral atypical central serous chorioretinopathy: case report. 61
24013974 2013
28
Cushing syndrome related to leukemic infiltration of the central nervous system: a case report and a possible role of LIF. 61
23729555 2013
29
A rare case of Cushing syndrome by cyclic ectopic-ACTH. 61
22911286 2012
30
Bilateral adrenalectomy: lifesaving procedure in severe Cushing syndrome. 61
22441001 2012
31
ACTH-dependent Cushing syndrome: The potential benefits of simultaneous bilateral posterior retroperitoneoscopic adrenalectomy. 61
21238714 2011
32
Reduction of false-negative results in inferior petrosal sinus sampling with simultaneous prolactin and corticotropin measurement. 61
20713347 2011
33
[ACTH-dependent Cushing syndrome, a diagnostic challenge]. 61
19627738 2009
34
[Bilateral inferior petrosal sinus sampling in the differential diagnosis of ACTH-dependent Cushing's syndrome]. 61
18064362 2007
35
An assessment of petrosal sinus sampling for localization of pituitary microadenomas in children with Cushing disease. 61
16219718 2006
36
Cutaneous manifestations in a patient with a long-term history of untreated ACTH-dependent Cushing's syndrome. 61
16603099 2006
37
[ACTH-dependent Cushing's syndrome: a revision of 43 cases]. 61
16197843 2004
38
[Ectopic ACTH syndrome]. 61
15148825 2004
39
Case report: cushing disease caused by an ectopic intracavernous pituitary microadenoma: case report and review of the literature. 61
12794610 2003
40
Corticotropin-releasing hormone test: improvement of the diagnostic accuracy of simultaneous and bilateral inferior petrosal sinus sampling in patients with Cushing syndrome. 61
7740803 1995
41
The metyrapone and dexamethasone suppression tests for the differential diagnosis of the adrenocorticotropin-dependent Cushing syndrome: a comparison. 61
8042820 1994
42
[Adrenostatic treatment of ACTH-dependent Cushing syndrome using metyrapone and aminoglutethimide]. 61
2820688 1987

Variations for Acth-Dependent Cushing Syndrome

Expression for Acth-Dependent Cushing Syndrome

Search GEO for disease gene expression data for Acth-Dependent Cushing Syndrome.

Pathways for Acth-Dependent Cushing Syndrome

GO Terms for Acth-Dependent Cushing Syndrome

Sources for Acth-Dependent Cushing Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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